@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0588: (2015-12-02 )
MQDFKALENLQTKTLEAEKGGGLDRINKQHEKGKLTARERLSILLDENSFEEYDKFVKRHVTDFGMQNASFLGDGVVIGHGTIYGRKVFVYSQDFTVFGGSLGASHAKKICKIIDMAINVRVPIIGLNDSGGARIQEGVNSLAGYGELFQRNVNASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKNSSYMFITGPDVVKKVTYEDVNHEDLGGAKIHTSKTGVVDFAFNNDVEMLLKIREFFTFLPANNQELPKSVPICDDVDDINESLNTLIPHNPNTPYDMHELIEKVCDERNFFELKPDFARNIIIGFGRIKGNTVGIVANQPMYLAGCLDIDSSRKAARFVRFCDAFNIPITTLIDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLITRKAYGGAYIVMNSKHLKGDINYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKTRYHLYKALELLKNKKIERIWKKHDNLPL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......-.190.......200.......210.......220.......230.......240.......250------........260.--......270.......280.......290..-.....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.--------.---------.--..--.---------.450.---......460.......470.......480.......490.......500......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
D
F
K
A
L
E
N
L
Q
TKTLEAEKGGGL
D
R
I
N
K
Q
H
E
KGK
L
T
A
R
E
R
L
S
I
L
LDEN
S
F
E
E
Y
D
K
F
V
K
R
H
V
T
D
FGMQN
A
S
FLGD
G
V
V
IGHGTIY
G
R
K
V
F
V
Y
SQ
D
F
T
V
FGGSL
G
A
S
H
A
K
K
I
C
K
I
I
D
M
A
I
N
V
R
V
P
I
I
G
LNDSG
G
A
R
I
Q
E
G
V
N
S
L
A
G
Y
G
E
L
F
Q
RNVNASGVI
P
Q
I
S
L
I
MGPCAGGAVYSPAL
T
D
F
T
F
M
V
KN-S
S
Y
M
F
I
T
G
P
D
V
V
K
K
V
TYEDVNHEDLGG
A
K
I
HTSKT
G
V
V
D
F
AFNN
D
V
E
M
L
L
K
I
R
E
F
F
T
FLPANN-------QELPKSVPICD
D
--
V
D
D
I
N
E
S
L
N
T
LIPHNPNTP
Y
D
M
H
E
L
I
E
K
V
CD-ER
N
F
FELK
P
D
FAR
N
I
I
I
G
F
G
RIKG
N
T
V
G
I
VANQ
P
M
Y
L
A
G
C
LDIDSS
R
K
A
A
R
F
V
R
F
C
D
AFNI
P
I
T
T
L
IDVPGFLPGT
N
Q
E
Y
N
N
I
I
Q
H
G
A
K
L
L
Y
A
Y
AEATV
P
K
I
S
L
I
T
RKAYG
G
A
Y
I
V
M
NSKHLKGDI
N
Y
AWPT
A
E
I
A
V
MG
P
E
S
A
V
E
I
I
FR--------H---------E--K
D
--
Q
---------
Q
T
L
I
K
---
E
Y
K
E
KFANP
F
F
AASHGYIDDIIVPSK
T
R
Y
H
L
Y
K
A
L
E
L
L
KNK
K
I
E
R
I
W
K
KHDNLPL
21
PsiBlast_CBE
94.68
63%
-83
- C5 -
3N6R
2
?
L:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
HTA
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
57
HHSearch
94.50
55%
-78
- C5 -
3IAV
6
?
A:
[14-530]
--
T
A
G
K
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
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K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
---------
T
--
I
A
--
D
AGDDA
E
A
T
R
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
52
HHSearch
94.06
63%
-82
- C5 -
3N6R
2
?
B:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
--
L
G
--
D
P
E
K
I
-----
A
Q
H
T
A
---
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
3
PsiBlast_PDB
94.03
54%
-77
- C5 -
3IAV
6
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
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F
R
R
N
T
H
A
S
G
V
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P
Q
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L
V
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P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
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G
V
A
H
H
M
A
G
D
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K
D
A
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Y
V
K
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L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
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A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
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V
I
E
H
V
L
D
-
D
A
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F
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A
P
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I
L
T
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G
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Q
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A
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C
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A
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V
R
T
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D
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F
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V
P
V
L
T
F
V
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V
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G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
24
PsiBlast_CBE
94.02
63%
-82
- C5 -
3N6R
2
?
F:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
HTA
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
22
PsiBlast_CBE
94.01
63%
-83
- C5 -
3N6R
2
?
J:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
HTA
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
23
PsiBlast_CBE
93.84
63%
-81
- C5 -
3N6R
2
?
H:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
HTA
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
25
PsiBlast_CBE
93.78
63%
-82
- C5 -
3N6R
2
?
D:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
HTA
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
9
PsiBlast_PDB
93.76
54%
-79
- C5 -
3MFM
-
?
C:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
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L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
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A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
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K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
N
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
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K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
28
PsiBlast_CBE
93.69
54%
-75
- C5 -
1XNY
4
?
B:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
7
PsiBlast_PDB
93.44
54%
-77
- C5 -
1XNY
4
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
T
I
A
D
AGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
26
PsiBlast_CBE
93.15
54%
-79
- C5 -
3IAV
4
?
B:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
6
PsiBlast_PDB
93.10
54%
-78
- C5 -
1XNV
-
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
1
PsiBlast_PDB
92.96
63%
-83
- C5 -
3N6R
2
?
B:
[26-531]
------
L
E
Q
L
E
D
R
R
A
A
A
R
L
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
F
E
E
F
D
M
F
V
T
H
R
C
T
D
F
N
M
Q
D
Q
K
P
A
G
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
G
E
V
F
Q
R
N
I
M
A
S
G
V
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
N
-------
R
E
K
P
P
V
R
P
F
F
D
D
--
P
D
R
I
E
P
S
L
D
T
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
-
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
G
A
T
E
I
I
H
R
--------
G
---------
D
L-
G
D
--
P
---------
E
K
I
A
Q
H
T
A
D
Y
E
E
R
F
A
N
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
53
HHSearch
92.89
57%
-82
- C5 -
1VRG
2
?
A:
[14-527]
-
S
L
R
D
K
I
E
E
L
K
K
I
E
K
E
I
E
Q
G
G
G
P
E
K
V
E
K
Q
H
R
A
G
K
L
T
A
W
E
R
L
E
L
L
L
D
P
G
T
F
V
E
I
D
K
F
V
E
H
R
N
T
Y
F
G
L
D
K
V
K
L
P
R
D
G
V
I
T
G
V
G
E
I
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
K
M
G
I
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
L
A
G
Y
G
E
I
F
L
R
N
T
L
A
S
G
V
V
P
Q
I
T
V
I
A
G
P
C
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
V
M
V
D
Q
-
T
A
R
M
F
I
T
G
P
N
V
I
K
A
V
T
G
E
E
I
S
Q
E
D
L
G
G
A
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
V
R
T
L
L
S
Y
L
P
S
N
N
-------
A
E
E
P
P
V
E
D
P
D
T
---
S
L
E
T
P
E
D
I
L
D
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
V
V
D
-
H
G
E
F
F
E
V
Q
P
Y
F
A
K
N
I
V
I
G
F
A
R
I
Q
G
K
T
V
G
I
V
A
N
Q
P
S
V
L
A
G
V
L
D
I
D
S
S
D
K
A
A
R
F
I
R
F
L
D
A
F
N
I
P
I
L
T
F
V
D
T
P
G
Y
L
P
G
V
A
Q
E
H
G
G
I
I
R
H
G
A
K
L
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
I
L
R
K
A
Y
G
G
A
Y
I
A
M
G
S
K
H
L
G
A
D
M
V
L
A
W
P
S
A
E
I
A
V
M
G
P
E
G
A
A
N
I
I
F
K
--------
R
---------
E
--
I
E
--
A
SSN
P
E
E
T
R
-
R
K
L
I
E
---
E
Y
K
Q
Q
F
A
N
P
Y
I
A
A
S
R
G
Y
V
D
M
V
I
D
P
R
E
T
R
K
Y
I
M
R
A
L
E
V
C
E
T
K
V
E
Y
R
P
K
K
K
H
G
N
I
P
L
8
PsiBlast_PDB
92.54
54%
-78
- C5 -
1XO6
-
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
D
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
T
I
A
D
AGDDA
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
13
PsiBlast_PDB
92.36
52%
-82
- C5 -
2BZR
-
PCC5_MYCTU
A:
[29-548]
------
L
A
E
L
H
K
R
R
E
E
S
L
H
P
V
G
E
D
A
V
E
K
V
H
A
K
G
K
L
T
A
R
E
R
I
Y
A
L
L
D
E
D
S
F
V
E
L
D
A
L
A
K
H
R
S
T
N
F
N
L
G
E
K
R
P
L
G
D
G
V
V
T
G
Y
G
T
I
D
G
R
D
V
C
I
F
S
Q
D
A
T
V
F
G
G
S
L
G
E
V
Y
G
E
K
I
V
K
V
Q
E
L
A
I
K
T
G
R
P
L
I
G
I
N
D
G
A
G
A
R
I
Q
E
G
V
V
S
L
G
L
Y
S
R
I
F
R
N
N
I
L
A
S
G
V
I
P
Q
I
S
L
I
M
G
A
A
A
G
G
H
V
Y
S
P
A
L
T
D
F
V
I
M
V
D
Q
-
T
S
Q
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
E
V
T
M
E
E
L
G
G
A
H
T
H
M
A
K
S
G
T
A
H
Y
A
A
S
G
E
Q
D
A
F
D
Y
V
R
E
L
L
S
Y
L
P
P
N
N
STDAPR
Y
Q
A
A
A
P
T
G
P
I
E
E
N
--
L
T
D
E
D
L
E
L
D
T
L
I
P
D
S
P
N
Q
P
Y
D
M
H
E
V
I
T
R
L
L
D
-
D
-
E
F
L
E
I
Q
A
G
Y
A
Q
N
I
V
V
G
F
G
R
I
D
G
R
P
V
G
I
V
A
N
Q
P
T
H
F
A
G
C
L
D
I
N
A
S
E
K
A
A
R
F
V
R
T
C
D
C
F
N
I
P
I
V
M
L
V
D
V
P
G
F
L
P
G
T
D
Q
E
Y
N
G
I
I
R
R
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
K
I
T
V
I
T
R
K
A
Y
G
G
A
Y
C
V
M
G
S
K
D
M
G
C
D
V
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
S
G
A
V
G
F
V
Y
R
--------
Q
---------
Q
I
D
K
L
--
R
---------
L
R
L
Q
Q
---
E
Y
E
D
T
L
V
N
P
Y
V
A
A
E
R
G
Y
V
G
A
V
I
P
P
S
H
T
R
G
Y
I
G
T
A
L
R
L
L
E
R
K
------
K
K
H
G
N
V
P
L
4
PsiBlast_PDB
91.81
54%
-79
- C5 -
3IB9
3
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
L
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDD
A
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
5
PsiBlast_PDB
91.77
54%
-76
- C5 -
3IBB
-
?
A:
[18-530]
------
L
A
D
L
R
R
R
I
E
E
A
T
H
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
G
S
F
V
E
L
D
E
F
A
R
H
R
S
T
N
F
G
L
D
A
N
R
P
Y
G
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
G
V
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
N
-------
L
S
E
P
P
A
F
P
E
E
A
D
LA
V
T
D
E
D
A
E
L
D
T
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
-
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
A
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
G
A
V
N
I
L
H
R
--------
R
TIADAGDD
A
E
--
A
T
--
R
---------
A
R
L
I
Q
---
E
Y
E
D
A
L
L
N
P
Y
T
A
A
E
R
G
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
55
HHSearch
91.65
53%
-78
- C5 -
1X0U
-
?
A:
[11-523]
----
K
L
I
E
E
L
R
Q
L
K
E
K
A
Y
K
G
G
G
D
E
R
I
Q
F
Q
H
S
K
G
K
L
T
A
R
E
R
L
A
L
L
F
D
D
G
K
F
N
E
I
M
T
F
A
T
T
R
A
T
E
F
G
L
D
K
Q
R
F
Y
G
D
G
V
V
T
G
W
G
K
V
D
G
R
T
V
F
A
Y
A
Q
D
F
T
V
L
G
G
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L
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L
P
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N
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-------
M
E
E
P
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Y
I
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--
A
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A
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R
I
L
Y
R
--------
K
---------
E
--
I
Q
--
Q
ASNPDDVL-
K
Q
R
I
A
---
E
Y
R
K
L
F
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P
Y
W
A
A
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L
38
PsiBlast_CBE
77.57
38%
-91
- C5 -
4G2R
4
PCC6_MYCTO
B:
[41-466]
--------------------------------------------------------------------------
G
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-----
G
-------