@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0592: (2015-12-03 )
MDYILASLSLPFFITENYLLITALVPLLSAVVILFTGKWPTVSNGITVASSVLLFVYTCLCTLYWAYGDHSQFILINFGNNLHVSLKLESTGVVFSLLISFLWILTSIYTIYYMQNNYPDSNYSDFLCFLLVSISCTMFIAFSGDLLTTFVFYELLTISTYPLVTYNATNESTIAGRYYFGVLFFSSLVLFFPVLGLLYNEFHTLDFVSSGIFEFDTSLVTFTAVCFTMLIYGLGKAALMPMHFWLPRAMVAPTPVSALLHAVAVVKSGAFIIVKVILYTFGIDNLQRFAQQNWFAGGWLPYAAGFTIIAASLIALKQKELKRLLAYSTVSQLSYIILFASIFSDLSARVAIFQLVCHAFAKITLFFIAGSIITKTGEKYIDRIHGIGRSMPVTMVAFAIGALSMIGVPPASTFWGKFLIFQAVFNSGNIALSVFVTLVLTVGTVLNAMYFLPIIYNAFFSKSSKNFFIKKIPVFLILPPVITAICTFIIFLVTPFILPLC
Atome Classification :
(20 SA)
--------------------.........10........20......------..30.....-...40........50...--.....60.......-------.70-..--.......80...--......90........100.......110.......120.......130.......140.......150.......160.....-..-----170........180......--.190.....----..200...--..---..-----..210.....--..220.......230.-.-.....240.......250........260.......270.-..-.---------...280.......290.....--..300...----..------..310.......320.--......330.......340..--.....350.......360.......370..---.-.-...380.......390.......----400.......-410........420.--......430.......440.......450.......460.....---..470...---....480...-....490--........500------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------M
D
Y
I
L
A
SLSL
P
F
F
I
TEN
Y
L
L
I
T
A
L
V
P
L
------
L
S
A
V
V
I
L
FT-GKWPTVSN
G
I
T
V
A
S
S
V
L
L
--
F
V
Y
T
C
L
C
T
L
Y
W
AYG-------DH--S
Q
--
F
I
L
I
NFG
N
-
N
L
H
--
V
S
L
K
LEST
G
V
V
F
S
L
L
I
S
F
L
W
I
L
T
S
I
Y
T
I
Y
Y
M
QNNYPDS
N
Y
S
D
F
L
C
F
L
L
V
SIS
C
T
M
F
I
A
FSG
D
L
L
T
T
F
V
F
Y
E
L
L
TIST
Y
P
L
V
T
YN-AT-----N-E
S
T
I
A
G
R
Y
Y
F
G
V
L
F
F
S
S
L
--
V
L
F
F
P
V
L
G
L
----
L
Y
N
--
E
F
H
--
T
L
---
D
F
-----
V
S
S
G
I
F
E
FD
T
--
S
L
V
T
F
T
A
V
C
F
T
M
L
I
Y
G-L-
G
K
A
A
L
M
P
M
H
F
WLPRAM-VAP
T
P
V
S
A
L
L
H
A
V
A
V
VKSG
A
F
I
I
-
V
K
-
V
---------
I
L
Y
TF
G
I
D
N
L
Q
R
F
A
QQNWFAG--G
W
L
PYAA
G
----
F
T
------
I
I
A
A
S
L
I
A
L
K
Q
K
E
L
K
R
--
L
L
A
Y
S
T
V
S
Q
L
S
Y
I
I
L
F
A
S
I
F
S
--
D
L
S
A
R
V
A
I
F
Q
L
V
C
H
A
F
A
K
I
T
L
F
F
I
A
G
S
I
I
T---K-T-
G
E
K
Y
I
D
R
I
H
GIGRSM
P
V
T
M
V
A
F
A
----
I
G
A
L
S
MIGVP-P-
A
S
T
F
W
G
K
F
L
I
F
Q
A
--
V
FNSGN
I
A
L
S
V
F
V
T
L
V
L
T
V
G
T
V
L
N
A
M
Y
F
L
P
I
I
Y
N
A
F
FSKSSK
N
F
---
F
I
K
KI
P
V
F
---
L
IL
P
P
V
I
T
A
I
-
C
T
F
I
I
-
F
--
L
V
T
P
F
ILPLC-------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
96.32
24%
-167
- C2 -
3RKO
4
?
B:
[1-612]
-----------------------------------
M
N
M
L
A
L
T
I
I
L
P
L
------
I
G
F
V
L
L
A
F
S
-
R
G
R
W
S
E
N
V
S
A
I
V
G
V
G
S
V
G
--
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
N
GE
Q
T
Y
S
Q
--
P
L
--
W
T
W
M
S
V
G
D
F
N
I
G
--
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
---
E
E
G
Y
S
R
F
F
A
Y
T
N
L
F
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
-
Y
T
-----
D
-
P
K
N
G
A
A
A
M
K
A
F
V
V
T
R
V
G
D
--
V
F
L
A
F
A
L
F
I
----
L
Y
N
--
E
L
G
--
T
L
N
F
R
E
M
-----
V
E
L
A
P
A
H
F
A
D
--
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
A
-
V
-
G
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
G
V
Y
L
I
-
A
R
--------------------
T
H
G
L
F
L
M
T
P
E
V
L
--
H
L
V
G
I
V
G
A
----
V
T
------
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
--
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
Q
A
-----
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
---
A
-
C
H
H
E
Q
N
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
----
V
G
G
A
A
L
S
A
L
P
-
L
V
T
A
G
F
F
S
K
D
E
I
L
A
G
--
A
M
A
N
G
H
----
I
N
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
E
Q
I
H
A
---
H
A
V
K
G
V
T
H
---
S
L
P
L
I
V
L
L
I
L
-
S
T
F
V
G
-
A
--
L
I
V
P
P
L
Q
G
V
L
PQTTELAH
G
S
M
L
T
L
E
I
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
WLGKR
T
L
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
AWG
F
D
W
L
Y
D
K
VF
V
K
P
F
L
G
I
A
W
L
L
KRD
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
L
L
LSENGY
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
1
PsiBlast_PDB
94.94
26%
-165
- C2 -
3RKO
5
?
L:
[2-473]
------------------------------------
N
M
L
A
L
T
I
I
L
P
L
------
I
G
F
V
L
L
A
F
S
R
G
R
W
S
E
N
V
S
A
I
V
G
V
G
S
V
G
L
AA
L
V
T
A
F
I
G
V
D
F
F
A
N
G
-------
E
Q
TY
S
Q
PL
W
T
W
M
S
V
G
D
F
N
I
G
--
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
---
E
E
G
Y
S
R
F
F
A
Y
T
N
L
F
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
-
Y
T
-----
D
P
K
N
G
A
A
A
M
K
A
F
V
V
T
R
V
G
D
V
--
F
L
A
F
A
L
F
-
I
----
L
Y
N
--
E
L
G
--
T
L
---
N
F
REMVE
L
A
P
A
H
F
A
D
G
N
--
N
M
L
M
W
A
T
L
---
M
L
L
G
G
A
V
-
G
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
G
V
Y
L
I
-
A
R
-
T
HGLFLMTPE
V
L
H
L
V
G
I
---------------------
V
G
A
----
V
T
------
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
--
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
-----
Q
A
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
---
A
-
C
H
H
E
Q
N
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
----
V
G
G
A
A
L
S
A
L
P
L
V
-
T
A
G
F
F
S
K
D
E
I
L
A
G
--
A
M
A
N
G
H
I
N
L
M
V
----
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
E
Q
I
H
A
---
H
A
V
K
-
G
V
T
---
H
S
L
P
L
I
V
L
L
I
L
S
T
F
V
G
-
A
--
L
I
V
P
P
L
Q
G
V
L
-------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
84.23
26%
-158
- C2 -
3RKO
4
?
L:
[75-470]
--------------------------------------------------------------------------------------------------------------------------
I
G
--
F
N
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
G
E
-
E
G
--
Y
S
R
F
F
A
Y
T
N
L
F
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
F
Y
Y
T
D
-----
P
-
K
N
G
A
A
A
M
K
A
F
V
V
T
R
V
G
-
D
--
V
F
L
A
F
A
L
F
I
----
L
Y
N
--
E
L
G
--
T
L
---
N
F
-----
R
E
M
V
E
L
A
P
A
H
FA
D
G
N
N
M
L
M
W
A
T
L
M
L
L
G
G
-
A
V
G
K
S
A
Q
L
P
L
Q
T
W
L
A
D
A
M
-
A
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
G
V
Y
L
I
-
A
R
-
T
---------
H
G
L
F
L
M
T
----------
P
E
V
L
--
H
L
V
G
I
V
G
A
----
V
T
------
L
L
L
A
G
F
A
A
L
V
Q
T
D
I
K
R
--
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
A
L
G
V
Q
A
-----
W
D
A
A
I
F
H
L
M
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
---
A
-
C
H
H
E
Q
N
I
F
K
M
G
G
L
R
K
S
I
P
L
V
Y
L
C
F
L
----
V
G
G
A
A
L
S
A
L
P
-
L
V
T
A
G
F
F
S
K
D
E
I
L
A
G
--
A
M
A
N
G
H
I
----
N
L
M
V
A
G
L
V
G
A
F
M
T
S
L
Y
T
F
R
M
I
F
I
V
F
H
G
K
E
Q
I
H
----
A
H
A
V
K
G
V
T
---
H
S
L
P
L
I
V
L
L
I
-
L
S
T
F
V
-
G
--
A
L
I
V
P
P
L
Q
G
V
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.82
27%
-158
- C2 -
4HEA
-
NQO12_THET8
L:
[66-466]
-------------------------------------------------------------------------------------------------------------------------------
S
L
L
L
D
N
L
S
G
F
M
L
L
I
V
T
G
V
G
F
L
I
H
V
Y
A
I
G
Y
M
G
G
---
D
P
G
Y
S
R
F
F
A
Y
F
N
L
F
I
A
M
M
L
T
L
V
L
A
D
S
Y
P
V
M
F
I
G
W
E
G
V
G
L
A
S
F
L
L
I
G
F
W
-
Y
K
-----
N
P
Q
Y
A
D
S
A
R
K
A
F
I
V
N
R
I
G
D
L
GF
M
L
G
M
A
I
L
W
A
----
L
Y
G
TL
S
I
S
--
E
L
---
K
E
-----
A
M
E
G
P
L
K
N
P
D
--
L
L
A
L
A
G
L
L
L
F
L
G
A
V
-----
G
K
S
A
Q
I
P
L
M
V
W
L
P
D
A
M
-
A
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
G
V
Y
L
I
-
A
R
S
S
---------
F
L
Y
S
V
L
P
D
-----------------
V
S
Y
A
I
A
VVGL
L
T
------
A
A
Y
G
A
L
S
A
F
G
Q
T
D
I
K
K
--
I
V
A
Y
S
T
I
S
Q
L
G
Y
M
F
L
A
A
G
V
G
A
--
Y
W
---
V
A
L
F
H
V
F
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
H
---
A
L
G
-
G
E
Q
D
V
R
K
M
G
G
L
W
K
H
L
P
Q
T
R
W
H
A
L
----
I
G
A
L
A
L
G
G
L
P
-
L
-
L
S
G
F
W
S
K
D
A
I
L
A
A
TL
T
Y
P
F
G
G
V
G
F
Y
V
G
A
L
L
V
----
A
V
L
T
A
M
Y
A
M
R
W
F
V
L
V
F
L
G
E
E
R
G
H
H
---
H
P
H
E
A
P
P
V
---
M
L
W
P
N
H
L
L
A
L
-
G
S
V
L
A
G
Y
--
L
A
L
P
H
P
L
P
N
V
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.48
27%
-160
- C2 -
4HE8
1
NQO12_THET8
L:
[66-466]
-------------------------------------------------------------------------------------------------------------------------------
S
L
L
L
D
N
L
S
G
F
M
L
L
I
V
T
G
V
G
F
L
I
H
V
Y
A
I
G
Y
M
G
G
---
D
P
G
Y
S
R
F
F
A
Y
F
N
L
F
I
A
M
M
L
T
L
V
L
A
D
S
Y
P
V
M
F
I
G
W
E
G
V
G
L
A
S
F
L
L
I
G
F
W
-
Y
K
-----
N
P
Q
Y
A
D
S
A
R
K
A
F
I
V
N
R
I
G
D
L
GF
M
L
G
M
A
I
L
W
A
----
L
Y
G
TL
S
I
S
--
E
L
---
K
E
-----
A
M
E
G
P
L
K
N
P
D
--
L
L
A
L
A
G
L
L
L
F
L
G
A
V
-----
G
K
S
A
Q
I
P
L
M
V
W
L
P
D
A
M
-
A
G
P
T
P
V
S
A
L
I
H
A
A
T
M
V
T
A
G
V
Y
L
I
-
A
R
S
S
---------
F
L
Y
S
V
L
P
D
-----------------
V
S
Y
A
I
A
VVGL
L
T
------
A
A
Y
G
A
L
S
A
F
G
Q
T
D
I
K
K
--
I
V
A
Y
S
T
I
S
Q
L
G
Y
M
F
L
A
A
G
V
G
A
--
Y
W
---
V
A
L
F
H
V
F
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
H
---
A
L
G
-
G
E
Q
D
V
R
K
M
G
G
L
W
K
H
L
P
Q
T
R
W
H
A
L
----
I
G
A
L
A
L
G
G
L
P
-
L
-
L
S
G
F
W
S
K
D
A
I
L
A
A
TL
T
Y
P
F
G
G
V
G
F
Y
V
G
A
L
L
V
----
A
V
L
T
A
M
Y
A
M
R
W
F
V
L
V
F
L
G
E
E
R
G
H
H
---
H
P
H
E
A
P
P
V
---
M
L
W
P
N
H
L
L
A
L
-
G
S
V
L
A
G
Y
--
L
A
L
P
H
P
L
P
N
V
-------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
81.37
20%
-163
- C2 -
3RKO
4
?
N:
[63-477]
--------------------------------------------------------------------------------------------------------------------------
V
T
--
P
L
M
R
V
D
G
F
A
M
L
Y
T
G
L
V
L
L
A
S
L
A
T
C
T
F
A
Y
P
W
L
E
G
Y
N
D
N
--
K
D
E
F
Y
L
L
V
L
I
A
A
L
G
G
I
L
L
A
N
A
N
H
L
A
S
L
F
L
G
I
E
L
I
S
L
P
L
F
G
L
V
G
Y
A
F
R
Q
-----
K
-
R
S
L
E
A
S
I
K
Y
T
I
L
S
A
A
A
-
S
--
S
F
L
L
F
G
M
A
L
----
V
Y
A
--
Q
S
G
--
D
L
---
S
F
-----
V
A
L
G
K
--------
N
E
P
L
L
L
A
G
F
G
L
M
I
V
G
-
L
G
F
K
L
S
L
V
P
F
H
L
W
T
P
D
V
Y
Q
G
A
P
A
P
V
S
T
F
L
-
A
T
-
A
S
K
I
A
I
F
G
V
V
M
R
-
L
---------
F
L
Y
A
P
V
G
D
--------
S
E
A
I
R
--
V
V
L
A
I
I
A
F
----
A
S
------
I
I
F
G
N
L
M
A
L
S
Q
T
N
I
K
R
--
L
L
G
Y
S
S
I
S
H
L
G
Y
L
L
V
A
L
I
A
L
Q
TG
E
M
S
M
E
A
V
G
V
Y
L
A
G
Y
L
F
S
S
L
G
A
F
G
V
V
S
L
M
S
S
PYR
G
-
P
-
D
A
D
S
L
F
S
Y
R
G
L
F
W
H
R
P
I
L
A
A
V
M
T
----
V
M
M
L
S
L
A
G
I
P
-
M
-
T
L
G
F
I
G
K
F
Y
V
L
A
V
--
G
V
Q
A
H
L
W
----
W
L
V
G
A
V
V
V
G
S
A
I
G
L
Y
Y
Y
L
R
V
A
V
S
L
Y
L
H
A
P
E
Q
--------
P
S
N
W
Q
YSA
G
G
I
V
V
L
I
S
A
L
-
L
V
L
V
L
-
G
--
V
W
P
Q
P
L
I
S
I
V
-------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
79.95
19%
-152
- C2 -
4HE8
1
NQO13_THET8
G:
[1-467]
-------------------------------------
M
V
V
L
A
V
L
L
P
V
------
V
F
G
A
L
L
L
L
G
-
L
P
R
A
L
G
V
L
G
A
G
L
S
F
L
L
N
L
--
Y
L
F
L
----
T
H
P
G
G
V
-------
A
H
--
A
F
--
Q
A
P
L
L
P
G
A
-
G
V
Y
--
W
A
F
G
L
D
G
L
S
A
L
F
F
L
T
I
A
L
T
V
F
L
G
A
L
V
A
----------
R
V
E
G
R
F
L
G
L
A
L
L
M
E
G
L
L
L
G
L
F
A
A
R
D
L
L
V
F
Y
V
F
F
E
A
A
L
I
P
A
L
L
M
L
Y
L
Y
-
G
G
-----
E
-
G
R
T
R
A
L
Y
T
F
V
L
F
T
L
V
G
S
L
--
P
M
L
A
A
V
L
G
A
----
R
L
L
---
S
G
--
S
P
---
T
F
-----
L
L
E
D
L
L
A
H
P
L
--
Q
E
E
A
A
F
W
V
F
L
G
F
A
L
A
F
-
A
-
I
K
T
P
L
F
P
L
H
A
W
L
P
P
F
H
-
Q
E
N
H
P
S
G
L
A
D
A
L
G
T
L
Y
K
V
G
V
F
A
F
-
F
R
-
F
---------
A
I
P
L
A
--------
P
E
G
F
A
Q
A
Q
--
G
L
L
L
F
L
A
A
----
L
S
------
A
L
Y
G
A
W
V
A
F
A
A
K
D
F
K
T
--
L
L
A
Y
A
G
L
S
H
M
G
V
A
A
L
G
V
F
S
G
T
--
P
E
G
A
M
G
G
L
Y
L
L
A
A
S
G
V
Y
T
G
G
L
F
L
L
A
G
R
L
Y
E
---
R
-
T
-
G
T
L
E
I
G
R
Y
R
G
L
A
Q
S
A
P
G
L
A
A
L
A
L
----
I
L
F
L
A
M
V
G
L
P
-
G
-
L
S
G
F
P
G
E
F
L
T
L
L
G
--
A
Y
K
A
-----
S
P
W
L
A
A
L
A
F
L
S
V
I
A
S
A
A
Y
A
L
T
A
F
Q
K
T
F
W
E
E
G
G
S
G
V
---
K
D
L
A
G
A
E
W
---
G
F
A
L
L
S
V
L
A
L
-
L
L
M
G
V
-
F
PG
Y
F
A
R
G
L
H
P
L
A
EAFAKLLGG----------------------------------------------------------------------------------------------------------------------------
15
HHSearch
78.10
18%
-161
- C2 -
3RKO
5
?
M:
[70-488]
--------------------------------------------------------------------------------------------------------------------
P
W
I
P
-
R
F
G
IS
I
H
L
A
I
D
G
L
S
L
L
M
V
V
L
T
G
L
L
G
V
L
A
V
L
C
S
W
K
E
I
E
K
---
Y
--
Q
G
F
F
H
L
N
L
M
W
I
L
G
G
V
I
G
V
F
L
A
I
D
M
F
L
F
F
F
F
W
E
M
M
L
V
P
M
Y
F
L
I
A
L
W
-
G
H
KASDG
K
-
T
R
I
T
A
A
T
K
F
F
I
Y
T
Q
A
S
-
G
--
L
V
M
L
I
A
I
L
A
LVFV
H
Y
N
--
A
T
G
VW
T
F
---
N
Y
-----
E
E
L
L
N
T
P
M
-----
S
S
G
V
E
Y
L
L
M
L
G
F
F
I
A
-
F
A
V
K
M
P
V
V
P
L
H
G
W
L
P
D
A
H
S
Q
A
P
T
A
G
S
V
D
L
-
A
G
I
L
L
K
T
A
A
Y
G
L
-
L
R
-
F
---------
S
L
P
L
F
P
N
A
S
--------
A
E
F
A
--
P
I
A
M
W
L
G
V
----
I
G
------
I
F
Y
G
A
W
M
A
F
A
Q
T
D
I
K
R
--
L
I
A
Y
T
S
V
S
H
M
G
F
V
L
I
A
I
Y
T
G
S
--
Q
L
A
Y
Q
G
A
V
I
Q
M
I
A
H
G
L
S
A
A
G
L
F
I
L
C
G
Q
L
Y
E
---
R
-
I
-
H
T
R
D
M
R
M
M
G
G
L
W
S
K
M
K
W
L
P
A
L
S
L
----
F
F
A
V
A
T
L
G
M
P
-
G
-
T
G
N
F
V
G
E
F
M
I
L
F
G
--
S
F
Q
V
V
P
V
-----
I
T
V
I
S
T
F
G
L
V
F
A
S
V
Y
S
L
A
M
L
H
R
A
Y
F
G
K
A
K
S
Q
I
ASQ
E
L
P
G
M
S
L
R
---
E
L
F
M
I
L
L
L
V
V
-
L
L
V
L
L
-
G
--
F
Y
P
Q
P
I
L
D
T
S
-------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
63.54
20%
-140
- C2 -
4D10
-
CSN3_HUMAN
C:
[3-403]
S
A
L
E
Q
F
V
N
S
V
R
Q
L
SAQGQM
T
Q
L
C
E
L
I
N
K
S
G
E
L
L
A
K
N
L
S
H
L
D
T
V
L
G
A
L
DVQE
H
S
L
G
V
L
A
V
L
F
V
K
F
S
M
P
S
V
P
D
F
E
T
L
F
S
Q
V
Q
L
--
F
I
S
T
C
-------
N
G
-------
E
H
--
I
R
--
Y
A
T
D
T
F
A
G
-
L
C
H
--
Q
L
T
N
A
L
V
E
R
---
K
Q
P
L
R
G
I
G
I
L
K
Q
A
I
D
K
M
Q
M
N
T
N
Q
L
T
S
I
H
A
D
L
C
Q
L
C
L
L
A
K
C
F
K
P
A
L
P
Y
-------------
L
D
V
D
M
M
D
I
C
K
E
N
G
A
Y
-----
D
-
A
K
H
F
L
C
Y
Y
Y
Y
G
G
M
I
Y
T
G
L
--
K
N
F
E
R
A
L
Y
F
----
Y
E
Q
--
A
I
T
--
T
P
---
A
M
-----
A
V
S
-------------------
H
I
M
L
E
S
-
Y
-
K
K
Y
I
L
V
S
L
I
L
-
L
G
K
V
Q
-
Q
L
P
K
Y
T
S
Q
I
V
G
R
F
I
K
P
L
S
N
A
Y
H
E
-
L
A
-
Q
---------
V
Y
S
T
N
N
P
S
E
L
R
N
L
V
N
K
H
-----------
S
E
T
----
F
T
R
D
NN
M
G
L
V
K
Q
C
L
S
S
L
Y
K
K
N
I
Q
R
--
L
T
--
K
T
F
L
T
L
S
L
Q
D
M
A
S
R
V
----
Q
L
S
G
P
Q
E
A
E
K
Y
V
L
H
M
I
E
D
-------
G
E
I
F
A
---
S
-
I
-
N
Q
K
D
------------------------
G
M
V
S
F
H
D
N
P
-
E
-
K
Y
------------------------------------
N
N
P
A
M
L
H
N
I
D
Q
E
M
L
K
C
I
E
L
D
E
---
R
L
K
A
M
D
Q
E
---
I
T
V
N
P
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
36.69
34%
33
- C2 -
4ELQ
1
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
36.57
34%
31
- C2 -
4ELR
2
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
36.33
34%
39
- C2 -
3WAE
2
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
36.14
34%
34
- C2 -
3WAF
1
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
36.03
34%
29
- C2 -
4ELO
-
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
35.72
34%
31
- C2 -
4ELP
1
?
A:
[142-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
R
F
A
R
E
K
G
L
V
G
R
V
G
W
T
P
T
Y
S
S
----
F
Q
------
D
M
V
A
G
M
I
A
L
Y
G
E
E
K
T
R
E
W
L
L
A
M
K
A
L
A
P
K
A
Y
P
S
N
P
A
M
L
D
A
--
I
R
A
G
E
V
D
L
G
S
T
N
H
Y
Y
V
V
R
F
R
R
A
G
Y
R
L
G
M
H
H
---
F
-
R
-
D
G
D
A
G
N
L
A
L
V
T
G
A
G
L
L
K
T
S
K
N
L
A
----
A
A
T
R
F
L
T
Y
L
L
-
S
-
P
Q
A
Q
Q
Y
F
V
G
N
I
G
E
--
Y
P
L
V
K
G
V
A
L
D
P
N
L
L
P
L
E
E
A
L
A
K
S
P
K
L
D
L
E
K
L
P
L
D
R
A
L
R
L
L
R
E
T
G
---
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
33.97
44%
217
- C2 -
4WMH
-
HMOX2_HUMAN
A:
[99-132]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
-
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
-
K
-
K
V
A
Q
R
A
L
K
L
P
S
T
G
--
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
---
A
F
E
Y
N
M
Q
I
---
F
N
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
33.51
44%
220
- C2 -
2Q32
1
HMOX2_HUMAN
A:
[129-162]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
-
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
-
K
-
K
V
A
Q
R
A
L
K
L
P
S
T
G
--
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
---
A
F
E
Y
N
M
Q
I
---
F
N
E
L
D
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
33.22
8%
2
- C2 -
3RKO
-
NUOK_ECOBD
K:
[10-48]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
I
L
F
V
L
G
L
T
G
L
V
I
R
R
N
L
L
F
M
L
I
G
L
E
I
M
I
N
A
S
A
L
A
F
V
V
A
-
G
S
-----
Y
-
W
G
Q
T
D
G
Q
V
M
Y
I
L
A
I
S
L
A
A
--
A
E
A
S
I
G
L
A
L
----
L
L
Q
--
L
H
R
--
R
R
---
Q
N
-----
L
N
I
D
S
V
S
E
M
R
--
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
31.03
44%
212
- C2 -
2QPP
1
HMOX2_HUMAN
A:
[129-162]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
-
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
-
K
-
K
V
A
Q
R
A
L
K
L
P
S
T
G
--
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
---
A
F
E
Y
N
M
Q
I
---
F
N
E
L
D
Q
A
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
30.70
25%
268
- C2 -
4YYP
-
?
B:
[1-32]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
A
Y
R
----
F
L
------
T
E
Q
D
R
Q
L
R
L
L
Q
A
Q
I
Q
R
--
L
L
E
A
Q
S
L
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------