@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0597: (2015-12-03 )
MTISILGAGAWGTAIANSLSGKQNVILWTHNKTTFESISRTRESDKLLGCQIPENVSVKLAIKETVNASAMIFAVPTQSLRKVCQQLHDCNLKKDVAIILACKGIEKSTLKLPSEIVNEVLPNNPVAIFSGPSFAIEVAKKLPYSMVLACQDDTLGSKLISELQQENIKLHFSSDVVGVQICAALKNVFAIACGIVLGKKLGFNAHAALVTKSMNEVKTLYLAKTDSVSIDIDTLLGPACLGDLIMTCTSLNSRNLSFGFKIGSSNNSFDAQQTLSEGKSVIEGFSTAQSAFNLAEKLKIKMPICEAVYRLLYESASIEDTISVFVG
Atome Classification :
(20 SA)
-------.........10........20------.-.--------..-.....30----..--..-----.....40..-.-.----...-.50.--..-..-...60....-.-..-.70.-.......80.....----...90----.-----.......100...---...--.--110....--...120--.......130.......140.......150.......--160.--..--....170.......180.......190......----.200-----.-......210.......220....-...230-.---........240.......250.......260...-.....270....-.----..280.......290.....--..300.........310.......320.....-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------
M
T
I
S
I
L
GAG
A
W
G
T
A
I
A
N
SLS-------G-K--------Q
N
-
V
I
L
W
TH-----NK--
T
T
-----
F
E
S
I
S
RTRE-S-D----
K
L
L-GCQI--PE-N
V
-
S
V
K
L
A
I
KET-V-NA-
S
A
M
I
-
F
AV
P
T
Q
S
L
R
K
V
C
Q
Q
----
L
H
DCN----L-----KK
D
V
A
I
I
L
A
CKGI---E
K
S
--
T
--
L
KL
P
S
E
I
--
V
N
E
VLP--NN
P
V
A
I
FSGP
S
F
A
I
E
V
A
K
KLP
Y
S
M
V
L
A
CQDDT
L
G
S
K
L
--
I
S
E
L
--
Q
Q--E
N
I
K
L
H
FSSD
V
V
G
V
Q
I
C
A
A
L
K
N
V
F
A
I
A
C
G
I
V
LG----KKLG-----F-N
A
H
A
A
L
V
T
K
S
MNE
V
K
T
L
Y
L
A
KTD-
S
V
S
I
---
D
---
I
D
TLL
G
P
A
C
L
G
D
L
I
M
T
C
TSLNSRN
L
S
F
G
F
-
K
IGS-SNNSF
D
A
Q
Q
T
L
S
-
E
----
G
K
S
V
I
E
G
F
S
T
A
Q
S
A
F
N
L
A
E
K
--
L
KI--KM
P
I
C
E
A
V
Y
R
L
L
Y
ESASIE
D
T
I
S
V
FVG-------------
43
Fugue
94.10
33%
-134
* C2 *
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
--------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
N
G
A
-
E
I
I
L
-
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
----
K
-----
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
--
Q
R
I
M
ST
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
-----
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
-----------
R
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
CGLQDEGLPPLFK
23
HHSearch
93.48
34%
-127
- C2 -
1EVY
1
GPDA_LEIME
A:
[16-343]
-------
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
-
L
----
F
L
K
-
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
Y
N
-
G
A
-
E
I
I
L
-
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
G
G
-
N
L
I
A
Y
A
K
----
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
--
Q
R
I
M
--
S
T
GD
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
----
G
----
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
---
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
21
PsiBlast_CBE
92.59
34%
-120
- C2 -
1N1E
1
GPDA_LEIME
B:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
IAYAK
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
QR
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
T
--------
S
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
3
PsiBlast_PDB
92.43
34%
-124
- C2 -
1JDJ
2
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C
-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
2
PsiBlast_PDB
92.38
34%
-124
- C2 -
1EVZ
2
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
5
PsiBlast_PDB
92.37
34%
-125
- C2 -
1M67
2
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C
-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
1
PsiBlast_PDB
92.33
34%
-125
- C2 -
1EVY
1
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
6
PsiBlast_PDB
92.02
34%
-122
- C2 -
1N1E
1
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C
-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
T
--------
S
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
4
PsiBlast_PDB
91.89
34%
-124
- C2 -
1M66
2
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C
-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
7
PsiBlast_PDB
91.58
34%
-123
- C2 -
1N1G
3
GPDA_LEIME
A:
[20-340]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
-
K
C
-------
R
E
-
V
C
V
W
H
M
-----
N
E
--
E
E
-----
V
R
L
V
N
E
K
R
E
-
N
-
V
----
L
F
L
K
G
V
Q
L
--
A
S
-
N
I
-
T
F
T
S
D
V
E
K
A
-
Y
-
N
G
-
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
----
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
---
E
R
S
--
T
--
L
K
F
P
A
E
I
--
I
G
E
F
L
P
--
S
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
----
L
G
M
G
-----
L
-
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
----
T
A
-
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
-
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
-----------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
--
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------
22
PsiBlast_CBE
91.24
33%
-125
- C2 -
3K96
2
GPDA_COXBU
B:
[32-337]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
-
K
G-------
Q
K
-
V
R
L
W
S
Y
-----
E
S
--
D
H
-----
V
D
E
M
Q
A
E
G
V
-
N
-
N
----
R
Y
L
P
N
Y
P
F
--
P
E
-
T
L
-
K
A
Y
C
D
L
K
A
S
-
L
-
E
G
V
T
D
I
L
-
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
-----
I
-----
D
A
K
T
R
I
A
W
G
T
K
G
L
---
A
K
G
--
S
---
R
L
L
H
E
V
--
V
A
T
E
L
G
--
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
--
I
E
R
L
--
H
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
----
L
K
L
G
-----
S
-
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
--------
V
S
V
FGG
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
-
A
L
G
E
-
G
V
D
K
K
E
A
Q
Q
A
I
G
-
Q
-------
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
--
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
-------------
8
PsiBlast_PDB
90.29
33%
-123
- C2 -
3K96
1
GPDA_COXBU
A:
[32-337]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
-
K
G-------
Q
K
-
V
R
L
W
S
Y
-----
E
S
--
D
H
-----
V
D
E
M
Q
A
E
G
V
-
N
-
N
----
R
Y
L
P
N
Y
P
F
--
P
E
-
T
L
-
K
A
Y
C
D
L
K
A
S
-
L
-
E
G
V
T
D
I
L
-
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
-----
I
-----
D
A
K
T
R
I
A
W
G
T
K
G
L
---
A
K
G
--
S
---
R
L
L
H
E
V
--
V
A
T
E
L
G
--
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
--
I
E
R
L
--
H
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
----
L
K
L
G
-----
S
-
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
--------
V
S
V
F
GG
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
-
A
L
G
E
-
G
V
D
K
K
E
A
Q
Q
A
I
G
-
Q
-------
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
--
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
-------------
26
HHSearch
90.10
32%
-114
- C2 -
3K96
1
GPDA_COXBU
A:
[30-349]
-------
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
-
K
G-------
Q
K
-
V
R
L
W
S
Y
-----
E
S
--
D
H
-----
V
D
E
M
Q
A
E
G
V
-
N
N
R
----
Y
L
P
-
N
Y
P
F
--
P
E
-
T
L
-
K
A
Y
C
D
L
K
A
S
L
E
-
G
V
-
T
D
I
L
-
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
-
L
----
I
-----
D
A
K
T
R
I
A
W
G
T
K
G
L
---
A
K
G
--
S
---
R
L
L
H
E
V
--
V
A
T
E
L
G
--
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
--
I
E
R
L
--
H
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
----
L
K
L
G
-----
S
-
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
G
----
G
----
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
-
A
L
G
E
-
G
V
D
---
K
K
E
A
Q
Q
-
A
----
I
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
--
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
-------------
28
HHSearch
89.14
37%
-111
- C2 -
1Z82
7
?
A:
[15-324]
-------
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
-
N
G-------
E
E
-
V
I
L
W
A
R
-----
R
K
--
E
I
-----
V
D
L
I
N
V
S
H
T
-
S
-
P
----
Y
V
E
-
E
S
K
----
I
-
T
V
-
R
A
T
N
D
L
E
E
I
-
K
-
K
E
-
D
I
L
V
-
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
----
L
P
V
-------------
K
P
S
M
V
L
N
L
S
K
G
I
---
E
I
K
--
T
--
G
K
R
V
S
E
I
--
V
E
E
I
L
G
---
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
---
K
E
L
--
Q
K
R
I
--
S
T
--
E
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
----
F
G
G
W
-----
D
-
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
M
F
F
G
----
A
----
D
---
Q
K
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
-
L
I
A
R
-
G
F
N
---
P
L
K
L
L
E
-
S
----
S
N
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
--
N
K
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
11
PsiBlast_PDB
88.53
29%
-118
- C2 -
1X0X
6
GPDA_HUMAN
A:
[11-344]
---------
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
-
N
A
A
Q
LAQFD
P
R
-
V
T
M
W
V
F
E
E
D
I
G
G
K
--
K
L
-----
T
E
I
I
N
T
Q
H
E
-
N
-
V
----
K
Y
L
P
G
H
K
L
--
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
-
E
-
D
A
-
D
I
L
I
-
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
K
G
-
H
----
L
-----
K
A
N
A
T
G
I
S
L
I
K
G
V
---
D
E
G
--
P
N
G
L
K
L
I
S
E
V
--
I
G
E
R
L
---
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
--
K
E
L
M
--
Q
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
----
L
G
F
G
-----
D
-
N
T
K
A
A
V
I
R
L
G
L
M
E
M
--
I
A
F
A
K
L
F
C
S
G
P
V
---
S
---
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
-
S
I
E
Q
L
E
K
E
--
L
L
-
N
----
G
Q
K
-
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
V
D
--
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
-------------
12
PsiBlast_PDB
88.38
29%
-116
- C2 -
1WPQ
6
GPDA_HUMAN
A:
[6-339]
---------
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
-
N
A
A
Q
LAQFD
P
R
-
V
T
M
W
V
F
EEDIG
G
K
--
K
L
-----
T
E
I
I
N
T
Q
H
E
-
N
-
V
----
K
Y
L
P
G
H
K
L
--
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
-
E
-
D
A
-
D
I
L
I
-
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
K
G
-
H
----
L
-----
K
A
N
P
T
G
I
S
L
I
K
G
V
---
D
E
G
--
P
NG
L
K
L
I
S
E
V
--
I
G
E
R
L
---
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
--
K
E
L
M
--
Q
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
----
L
G
F
G
-----
D
-
N
T
K
A
A
V
I
R
L
G
L
M
E
M
--
I
A
F
A
K
L
F
C
S
G
P
V
---
S
---
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
-
S
I
E
Q
L
E
K
E
--
L
L
-
N
----
G
Q
K
-
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
V
D
--
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
-------------
10
PsiBlast_PDB
87.56
30%
-123
- C2 -
1TXG
5
GPDA_ARCFU
A:
[1-328]
-------
M
I
V
S
I
L
G
A
G
A
M
G
S
A
L
S
V
P
L
V
-------
D
-
N
--------
G
N
E
V
R
I
W
G
T
-----
E
F
--
D
T
E
I
---
L
K
S
I
S
A
G
R
E
-
H
-
P
RLG
V
K
L
N
-
G
V
E
I
F
W
P
E
-
Q
L
-
E
K
C
L
E
-------
N
A
-
E
V
V
L
-
L
G
V
S
T
D
G
V
L
P
V
M
S
R
----
I
--
L
P
----
Y
-----
L
K
D
Q
Y
I
V
L
I
S
K
G
L
I
D
F
D
N
S
--
V
--
L
T
V
P
E
A
V
W
R
L
K
H
D
L
R
--
E
R
T
V
A
I
-
T
G
P
A
I
A
R
E
V
A
K
R
M
P
T
T
V
V
F
S
S
P
S
E
S
S
A
N
K
M
--
K
E
I
F
--
E
T
--
E
Y
F
G
V
E
V
T
T
D
I
I
G
T
E
I
T
S
A
L
K
N
V
Y
S
I
A
I
A
W
I
R
G
Y
E
S
R
K
N
V
E
-----
M
S
N
A
K
G
V
I
A
T
R
A
I
N
E
M
A
E
L
----
I
E
-
I
L
G
G
---
D
---
R
E
T
A
F
G
L
S
G
F
G
D
L
I
A
T
F
R
--
G
G
R
N
G
M
L
G
E
-
L
L
G
K
-
G
L
S
I
D
E
A
M
E
E
L
E
R
R
----
G
V
G
V
V
E
G
Y
K
T
A
E
K
A
Y
R
L
S
S
K
--
I
N
A
--
D
T
K
L
L
D
S
I
Y
R
V
L
Y
E
G
L
K
V
E
E
V
L
F
E
L
A
T
-------------
13
PsiBlast_PDB
86.57
29%
-111
- C2 -
1X0V
6
GPDA_HUMAN
A:
[11-344]
---------
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
-
N
A
A
Q
L
AQFD
P
R
-
V
T
M
W
V
F
E
E
D
I
G
G
K
--
K
L
-----
T
E
I
I
N
T
Q
H
E
-
N
-
V
----
K
Y
L
P
G
H
K
L
--
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
-
E
-
D
A
-
D
I
L
I
-
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
K
G
-
H
----
L
-----
K
A
N
A
T
G
I
S
L
I
K
G
V
---
D
E
G
--
P
NG
L
K
L
I
S
E
V
--
I
G
E
R
L
---
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
--
K
E
L
M
--
Q
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
----
L
G
F
G
-----
D
-
N
T
K
A
A
V
I
R
L
G
L
M
E
--
M
I
A
F
A
K
L
F
C
S
G
P
V
---
S
---
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
-
S
I
E
Q
L
E
K
E
--
L
L
-
N
----
G
Q
K
-
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
V
D
--
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
-------------
24
HHSearch
85.69
29%
-125
- C2 -
1X0V
6
GPDA_HUMAN
A:
[9-348]
-------
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
Q
-
F
D-------
P
R
-
V
T
M
W
V
F
-----
E
E
--
D
I
GGKK
L
T
E
I
I
N
T
Q
H
E
N
V
-
K
----
Y
L
P
-
G
H
K
L
--
P
P
-
N
V
-
V
A
V
P
D
V
V
Q
A
A
E
-
D
A
-
D
I
L
I
-
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
----
L
K
G
-
H
----
L
-----
K
A
N
A
T
G
I
S
L
I
K
G
V
---
D
E
G
PN
G
--
L
K
L
I
S
E
V
--
I
G
E
R
L
G
---
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
--
K
E
L
M
--
Q
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
----
L
G
F
G
-----
D
-
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
K
L
F
C
----
S
----
G
PVS
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
-
A
F
A
R
T
G
K
S
---
I
E
Q
L
E
K
-
E
LL--
N
G
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
--
K
G
L
VD
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
-------------
27
HHSearch
84.88
28%
-114
- C2 -
1TXG
5
GPDA_ARCFU
A:
[1-333]
-------
M
I
V
S
I
L
G
A
G
A
M
G
S
A
L
S
V
P
L
V
-------
D
-
N
G-------
N
E
-
V
R
I
W
G
T
-----
E
F
D
T
E
I
-----
L
K
S
I
S
A
G
R
E
H
P
-
R
----
L
-
G
--
V
K
L
--
N
G
V
E
I
-
F
W
P
E
Q
L
E
K
C
L
E
-
N
A
-
E
V
V
L
-
L
G
V
S
T
D
G
V
L
P
V
M
S
R
----
I
L
P
-
Y
----
L
-----
K
-
D
Q
Y
I
V
L
I
S
K
G
L
---
I
D
F
--
D
NS
V
L
T
V
P
E
A
--
V
W
R
L
K
H
DL
R
E
R
T
V
A
I
T
G
P
A
I
A
R
E
V
A
K
R
M
P
T
T
V
V
F
S
S
P
S
E
S
S
A
N
K
M
--
K
E
I
F
--
E
T
--
E
Y
F
G
V
E
V
T
T
D
I
I
G
T
E
I
T
S
A
L
K
N
V
Y
S
I
A
I
A
W
I
R
G
----
Y
E
S
R
K
NVEM
S
-
N
A
K
G
V
I
A
T
R
A
I
N
E
M
A
E
L
I
E
I
L
G
----
G
----
D
---
R
E
T
A
F
G
L
S
G
F
G
D
L
I
A
T
F
R
G
--
G
R
N
G
M
L
G
E
-
L
L
G
K
-
G
L
S
---
I
D
E
A
M
E
-
E
L
E
R
R
G
V
G
V
V
E
G
Y
K
T
A
E
K
A
Y
R
L
S
S
K
--
I
N
A
--
D
T
K
L
L
D
S
I
Y
R
V
L
Y
E
G
L
K
V
E
E
V
L
F
E
L
A
T
-------------