@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0602: (2015-12-03 )
MSIDLSLPELPVLYPRITVVGVGGAGGNAVNNMIQSNLQGVNFVVANTDAQALEKSLCDKKIQLGINLTKGLGAGALPDVGKGAAEESIDEIMEHIKDSHMLFITAGMGGGTGTGAAPVIAKATREARAGVKDKASKEKKILTVGVVTKPFGFEGVRRMRIAELGLEELQKYVDTLIVIPNQNLFRVANEKTTFSDAFKLADNVLHIGIRGVTDLMVMPGLINLDFADIETVMSEMGKAMIGTGEAEGEDRAISAAEAAISNPLLDNVSMKGAQGILINITGGGDMTLFEVDAAANRVREEVDENANIIFGATFDQAMEGRVRVSVLATGIDCSVTHDNKQETSSVNQDETSEEKKFEWSYSQTLLPEAKQAEQVSEGVKWSSNIYDIPAYLRRKK
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..--.--....230.......240.......250.......260.......270.......280.......290.......300.......310..-.....-320.......330.......340.......350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSIDLSLPEL
P
V
LY
P
R
I
T
V
V
G
VGGAG
G
N
A
V
N
N
M
I
Q
S
NLQG
V
N
F
V
V
ANT
D
A
Q
A
L
E
K
S
L
C
D
K
K
I
Q
LG
I
N
LTKGLGAGALPDVGK
G
A
A
E
E
S
I
D
E
I
M
E
H
IKDS
H
M
L
F
I
T
AGMGGGTGTGA
A
P
V
I
A
K
A
T
R
E
A
RAGVKDKASKE
K
K
I
L
T
V
G
V
V
TKPF
G
F
E
G
V
R
R
M
R
I
A
E
L
G
L
E
E
L
Q
K
Y
V
D
T
L
I
V
IPNQN
L
F
R
VANEKT
T
F
S
D
A
F
K
L
A
D
N
V
L
H
I
G
IRGVTDLMVMPGLINL--
D
--
F
A
D
I
E
T
V
M
S
E
M
G
K
A
MIGTGEAEGEDR
A
I
S
A
A
E
A
A
ISNPLLDNVSMKGA
Q
G
I
L
I
N
I
TGGG
D
M
T
L
F
E
V
D
A
A
A
N
R
V
R
E
E
V
DENA
N
I
I
F
GA
T
F
-
D
Q
A
ME-G
R
V
R
V
S
V
L
A
TG
I
D
C
S
V
THDNKQETSSVNQDETSEE
K
K
F
E
WSYSQTLLP
E
A
K
Q
A
E
Q
V
S
EGVKWSSNIY
D
I
P
A
Y
L
RRKK
76
HHSearch
95.33
49%
-101
* C3 *
1OFU
1
FTSZ_PSEAE
A:
[11-317]
-------------
T
A
V
I
K
V
I
G
V
G
G
G
G
G
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
------------
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
-
D
A
D
M
R
-
D
E
L
H
V
T
V
V
A
T
G
L
G
----------------------------------------------------------------
73
HHSearch
93.57
49%
-103
- C3 -
2VXY
2
FTSZ_BACSU
A:
[11-316]
-------------
L
A
S
I
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
------------
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
I
----------------------------------------------------------------
74
HHSearch
93.18
50%
-103
- C3 -
1RQ2
1
FTSZ_MYCTU
A:
[11-315]
-------------
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
------------
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
77
HHSearch
92.94
46%
-104
- C3 -
2VAP
1
FTSZ1_METJA
A:
[34-347]
----------
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
------------
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
P
-
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
58
PsiBlast_CBE
92.85
45%
-104
- C3 -
1W59
1
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
72
HHSearch
92.51
44%
-97
- C3 -
2VAW
1
FTSZ_PSEAE
A:
[2-316]
----
F
E
L
V
D
N
I
A
Q
T
A
V
I
K
V
I
G
V
G
G
G
G
G
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
------------
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
-
D
A
D
M
R
-
D
E
L
H
V
T
V
V
A
T
G
L
-----------------------------------------------------------------
52
PsiBlast_CBE
92.22
45%
-107
- C3 -
2VAP
1
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
54
PsiBlast_CBE
92.07
45%
-109
- C3 -
1W5B
1
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
--------------------------------------------------
48
PsiBlast_CBE
91.82
45%
-102
- C3 -
1W5E
1
FTSZ1_METJA
D:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
47
PsiBlast_CBE
91.80
45%
-101
- C3 -
1W5E
1
FTSZ1_METJA
E:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
--------------------------------------------------
45
PsiBlast_CBE
91.72
45%
-102
- C3 -
1W5E
1
FTSZ1_METJA
G:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
46
PsiBlast_CBE
91.55
45%
-102
- C3 -
1W5E
1
FTSZ1_METJA
F:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
56
PsiBlast_CBE
91.54
45%
-103
- C3 -
1W5A
2
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
--------------------------------------------------
44
PsiBlast_CBE
91.52
45%
-102
- C3 -
1W5E
1
FTSZ1_METJA
H:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
--------------------------------------------------
39
PsiBlast_CBE
91.48
48%
-93
- C3 -
1OFU
1
FTSZ_PSEAE
B:
[25-316]
---------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
------------
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
-
D
A
D
M
R
-
D
E
L
H
V
T
V
V
A
T
G
L
G
----------------------------------------------------------------
57
PsiBlast_CBE
91.45
45%
-104
- C3 -
1W59
1
FTSZ1_METJA
B:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
L
E
L
T
G
I
P
K
I
-----------------------------------------
53
PsiBlast_CBE
91.35
45%
-103
- C3 -
1W5B
1
FTSZ1_METJA
B:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
L
E
------------------------------------------------
61
PsiBlast_CBE
91.24
45%
-103
- C3 -
1FSZ
1
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
L
-------------------------------------------------
55
PsiBlast_CBE
91.22
45%
-104
- C3 -
1W5A
1
FTSZ1_METJA
B:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
K
L
E
------------------------------------------------
51
PsiBlast_CBE
91.01
45%
-101
- C3 -
1W5E
1
FTSZ1_METJA
A:
[39-344]
---------------
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
------------
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
-
D
E
N
L
E
-
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
D
T
G
L
K
R
K
---------------------------------------------------
23
PsiBlast_CBE
90.94
50%
-105
- C3 -
4KWE
1
FTSZ_MYCTU
C:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
----------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
9
PsiBlast_PDB
90.79
50%
-97
- C3 -
1RLU
2
FTSZ_MYCTU
A:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
12
PsiBlast_PDB
90.47
50%
-102
- C3 -
4KWE
1
FTSZ_MYCTU
A:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
40
PsiBlast_CBE
90.43
48%
-94
- C3 -
1OFU
1
FTSZ_PSEAE
A:
[25-316]
---------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
------------
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
-
D
A
D
M
R
-
D
E
L
H
V
T
V
V
A
T
G
L
G
----------------------------------------------------------------
24
PsiBlast_CBE
90.22
50%
-105
- C3 -
4KWE
1
FTSZ_MYCTU
B:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
----------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
8
PsiBlast_PDB
90.10
50%
-97
- C3 -
2Q1Y
1
FTSZ_MYCTU
A:
[22-312]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
7
PsiBlast_PDB
89.66
50%
-99
- C3 -
2Q1X
1
FTSZ_MYCTU
A:
[22-312]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
-------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
10
PsiBlast_PDB
89.63
50%
-102
- C3 -
1RQ2
1
FTSZ_MYCTU
A:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
11
PsiBlast_PDB
89.61
50%
-101
- C3 -
1RQ7
1
FTSZ_MYCTU
A:
[25-315]
---------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
-
D
D
S
L
G
-
D
E
V
R
V
T
V
I
A
A
G
F
-----------------------------------------------------------------
34
PsiBlast_CBE
88.58
49%
-102
- C3 -
2RHO
1
FTSZ_BACSU
A:
[20-304]
--------------------------------
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
L
----------------------------------------------------------------
35
PsiBlast_CBE
88.47
49%
-97
- C3 -
2RHL
1
FTSZ_BACSU
B:
[20-304]
--------------------------------
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
L
E
N
L
Y
F
Q
G
H
H
H
------------------------------------------------------
36
PsiBlast_CBE
88.37
49%
-102
- C3 -
2RHL
1
FTSZ_BACSU
A:
[20-304]
--------------------------------
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
L
----------------------------------------------------------------
33
PsiBlast_CBE
87.85
49%
-98
- C3 -
2RHO
1
FTSZ_BACSU
B:
[20-304]
--------------------------------
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
--
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
15
PsiBlast_PDB
87.78
49%
-95
- C3 -
3VOA
2
FTSZ_STAAM
A:
[22-307]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
16
PsiBlast_PDB
87.74
49%
-94
- C3 -
3VOB
3
FTSZ_STAAM
A:
[22-307]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
14
PsiBlast_PDB
87.56
47%
-97
- C3 -
4M8I
2
FTSZ_STAEQ
A:
[36-327]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
G
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
S
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
E
D
K
P
S
S
-----------------------------------------------------------
42
PsiBlast_CBE
87.41
43%
-95
- C3 -
3WGK
1
FTSZ_STAAM
A:
[32-316]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
G
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
D
----------------------------------------------------------------
6
PsiBlast_PDB
87.11
44%
-101
- C3 -
2VXY
2
FTSZ_BACSU
A:
[30-316]
--------------------------------
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
------------
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
-
N
E
N
L
K
-
D
E
I
V
V
T
V
I
A
T
G
F
I
----------------------------------------------------------------
27
PsiBlast_CBE
86.97
44%
-99
- C3 -
3WGM
1
FTSZ_STAAM
B:
[32-314]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
------------------------------------------------------------------
18
PsiBlast_PDB
86.96
44%
-99
- C3 -
3WGM
1
FTSZ_STAAM
A:
[32-314]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
------------------------------------------------------------------
2
PsiBlast_PDB
86.96
44%
-101
- C3 -
4DXD
2
FTSZ_STAAU
A:
[36-324]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
D
D
K
--------------------------------------------------------------
19
PsiBlast_PDB
86.88
42%
-93
- C3 -
2VAW
1
FTSZ_PSEAE
A:
[25-316]
---------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
------------
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
-
D
A
D
M
R
-
D
E
L
H
V
T
V
V
A
T
G
L
-----------------------------------------------------------------
3
PsiBlast_PDB
86.79
44%
-94
- C3 -
3VO8
2
FTSZ_STAAM
A:
[32-318]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
D
----------------------------------------------------------------
41
PsiBlast_CBE
86.73
43%
-98
- C3 -
3WGK
1
FTSZ_STAAM
B:
[32-316]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
G
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
D
----------------------------------------------------------------
17
PsiBlast_PDB
86.60
44%
-97
- C3 -
3WGL
1
FTSZ_STAAM
A:
[32-315]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
78
HHSearch
86.31
45%
-91
- C3 -
1W5F
1
FTSZ_THEMA
A:
[22-336]
--------------
L
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
K
I
A
K
E
------------
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
T
S
R
--
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
-
H
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
-
D
D
E
V
P
D
D
E
I
R
V
I
F
I
A
T
R
F
P
D
E
D
K
I
L
F
P
--------------------------------------------------------
28
PsiBlast_CBE
86.25
44%
-94
- C3 -
3WGL
1
FTSZ_STAAM
B:
[32-316]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
D
----------------------------------------------------------------
22
PsiBlast_CBE
86.14
44%
-96
- C3 -
3VO8
2
FTSZ_STAAM
B:
[32-317]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
59
PsiBlast_CBE
85.96
45%
-90
- C3 -
1W5F
2
FTSZ_THEMA
B:
[23-326]
---------------
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
------------
K
I
A
K
E
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
--
T
SR
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
H
-
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
D
D
E
V
P
D
-
D
E
I
R
V
I
F
I
A
T
R
F
P
D
E
D
K
I
L
F
P
--------------------------------------------------------
4
PsiBlast_PDB
85.91
44%
-101
- C3 -
3WGN
1
FTSZ_STAAM
A:
[32-317]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
21
PsiBlast_CBE
85.35
44%
-102
- C3 -
3WGN
1
FTSZ_STAAM
B:
[32-317]
--------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
------------
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
-
N
P
E
L
Q
-
D
E
I
V
V
T
V
I
A
T
G
F
-----------------------------------------------------------------
60
PsiBlast_CBE
85.25
45%
-91
- C3 -
1W5F
1
FTSZ_THEMA
A:
[23-326]
---------------
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
------------
K
I
A
K
E
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
--
T
S
R
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
H
-
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
D
D
E
V
P
D
-
D
E
I
R
V
I
F
I
A
T
R
F
P
D
E
D
K
I
L
F
P
--------------------------------------------------------