@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0674: (2015-12-03 )
MNSKYKDVMMNDDLDSTTKQEALKYHIRGGNPGKISILPTKSLSTQYDLSLAYSPGVAAPCLEIAKNPDVVYDYTAKSNCVAVISNGTAVLGLGNIGPLASKPVMEGKAMLFKRFADIDAVDIEVDTENIEDFINAVRYLGPSWGGINLEDIRSPDCFIIEKRLNELMDIPVFHDDQHGTAVVVAAGIENALDIAGKKLEDVKIIMNGAGAAGIACLEILKSMGAKNIVLCDKQGVIYKGRNEDMNEWKEKYATDTKERSLLDAIKDTDVFIGLSAKDALNEEMLKNMGQNPIIFALANPDPEVRPELAKSVRPDAIIATGRSDYNNQVNNVMGFPYIFRGALDVHAMTINNEMKIAAADAIAKLAREPAPDEISAVYGGRKMSYGREYIIPTPFDPRLVSIVSPAVAKAAVCSGVAKKEIQDWSKYANQLKSRLANALNTLNLLSSQY
Atome Classification :
(20 SA)
.........10........20........--30........40....-....50........60..---......70...-...--.-------------.80........90........100-.......110.......---120---..----...----...------.-------------------------130------......-.-140.......150......-.160.......170.......180.......190.......200.......210--.......220------..----.----..--.------...230.......240.--.-.-------....---------250...--------.----.----.-.---260....--.--..--270...--.--...280.....---..---290-.........300--...---....310..-..-...-----------320-----------.......330.......340.......350.......360.......370.......380.......390......-.400.......410.......420.--.-..-.....430----.........440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNSKY
K
D
V
M
MNDDLD
S
T
T
K
Q
E
A
L
K
Y
H
I
RG--GNP
G
K
I
S
I
L
PTKSLS
T
-
Q
Y
D
L
S
L
AYSPGVA
A
P
C
L
E
---IAKNP
D
V
V
Y
D
Y-TAK--S-------------
N
C
V
A
V
ISNG
T
A
V
L
GLGNIGPLASK-PVME
G
K
A
M
L
F
K
R
FADI
D
---
A
-----
V
D
----
I
E
V----
D
T
E
------
N
-------------------------
I
E
D
------
F
I
N
A
V
R
-
Y
-LGPSWGGI
N
L
E
DIRSP
D
C
F
-
I
I
E
K
R
L
N
E
L
MDIPVFHDDQHG
T
A
V
V
V
AAGI
E
N
A
L
D
IAGKK
L
E
D
V
K
I
I
MNGAG
A
A
--
G
I
A
C
L
E
I
L
--------
K
S----M----GA--K------
N
I
V
L
CDKQ
G
V
I
YKGRNE--
D
-
M
-------
N
E
W
K
---------
E
K
YAT
D
--------
T
----
K
----
E
-
R
---
S
L
L
D
A
IK--D--T
D
--
V
F
I
GL
S
--
A
--
K
D
A
L
N
E
E
M
L
K
N---MG---Q---N
P
I
I
F
A
LANPDP--
E
V
R
---
P
E
L
A
K
SVRP-
D
A
-
I
I
A-----------TGR-----------SDYNNQVNNVMG
F
P
Y
I
F
RGA
L
D
V
H
A
M
T
INNE
M
K
I
A
A
A
D
A
I
A
K
L
AREPAP
D
E
I
S
A
V
YGGRKMSYGREYIIPTPFD
P
R
-
L
V
S
I
V
S
P
A
V
A
K
A
A
V
C
S
G
V
A
K
K
E
--
I
--
Q
-
D
W
-
S
K
Y
A
N
Q
------
L
K
S
R
L
A
N
A
L
N
T
L
N
L
L
SSQY
22
PsiBlast_CBE
86.57
43%
-91
- C3 -
2DVM
3
?
C:
[3-432]
------------------
R
E
K
A
L
E
F
H
K
N
N
FP
G
N
-
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
---
I
A
R
D
P
G
K
V
Y
E
Y
-
T
S
K
--
G
-------------
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
G
L
-
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
D
---
A
-----
F
P
----
I
M
I
----
K
E
Q
------
E
-------------------------
P
N
K
------
F
I
D
I
V
K
-
A
-
I
A
P
T
F
G
G
I
N
L
E
D
I
A
S
P
K
C
F
-
Y
I
L
E
R
L
R
E
E
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
--
G
F
A
T
L
R
I
L
--------
T
E
----
A
----
G
V
--
K
PE----
N
V
R
V
V
E
L
V
N
G
K
P
R
I
L
T
S
--
D
-
L
-------
D
L
E
K
LFPYRGWLL
K
K
T
N
G
E
--------
N
----
I
----
E
-
G
---
G
P
Q
E
A
L
K
--
D
--
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
V
I
K
P
Q
W
I
E
K
---
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
---
P
E
E
A
K
K
A
G
--
A
R
-
I
V
A
-----------
T
G
R
-----------
S
D
Y
P
N
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
S
I
V
E
E
P
S
----------------
E
E
N
I
I
P
S
P
L
N
P
I
-
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
E
G
V
A
R
T
K
--
V
--
K
G
E
W
V
E
E
H
T
I
R
------
L
I
E
F
Y
E
N
V
I
A
P
I
N
K
K
R
R
E
Y
1
PsiBlast_PDB
85.83
43%
-87
- C3 -
2DVM
3
?
A:
[3-432]
------------------
R
E
K
A
L
E
F
H
K
N
N
FP
G
N
-
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
---
I
A
R
D
P
G
K
V
Y
E
Y
-
T
S
K
--
G
-------------
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
G
L
-
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
D
---
A
-----
F
P
----
I
M
I
----
K
E
Q
------
E
-------------------------
P
N
K
------
F
I
D
I
V
K
-
A
-
I
A
P
T
F
G
G
I
N
L
E
D
I
A
S
P
K
C
F
-
Y
I
L
E
R
L
R
E
E
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
--
G
F
A
T
L
R
I
L
--------
T
E
----
A
----
G
V
--
K
PE----
N
V
R
V
V
E
L
V
N
G
K
P
R
I
L
T
S
--
D
-
L
-------
D
L
E
K
L
F
PYR
G
W
L
L
K
K
T
N
G
E
--------
N
----
I
----
E
-
G
---
G
P
Q
E
A
L
K
--
D
--
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
V
I
K
P
Q
W
I
E
K
---
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
---
P
E
E
A
K
K
A
G
--
A
R
-
I
V
A
-----------
T
G
R
-----------
S
D
Y
P
N
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
S
I
V
E
E
P
S
----------------
E
E
N
I
I
P
S
P
L
N
P
I
-
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
E
G
V
A
R
T
K
--
V
--
K
G
E
W
V
E
E
H
T
I
R
------
L
I
E
F
Y
E
N
V
I
A
P
I
N
K
K
R
R
E
Y
23
PsiBlast_CBE
85.55
43%
-87
- C3 -
2DVM
2
?
B:
[3-432]
------------------
R
E
K
A
L
E
F
H
K
N
N
FP
G
N
-
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
---
I
A
R
D
P
G
K
V
Y
E
Y
-
T
S
K
--
G
-------------
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
G
L
-
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
D
---
A
-----
F
P
----
I
M
I
----
K
E
Q
------
E
-------------------------
P
N
K
------
F
I
D
I
V
K
-
A
-
I
A
P
T
F
G
G
I
N
L
E
D
I
A
S
P
K
C
F
-
Y
I
L
E
R
L
R
E
E
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
--
G
F
A
T
L
R
I
L
--------
T
E
----
A
----
G
V
--
K
PE----
N
V
R
V
V
E
L
V
N
G
K
P
R
I
L
T
S
--
D
-
L
-------
D
L
E
K
LFPYRGWLL
K
K
T
N
G
E
--------
N
----
I
----
E
-
G
---
G
P
Q
E
A
L
K
--
D
--
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
V
I
K
P
Q
W
I
E
K
---
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
---
P
E
E
A
K
K
A
G
--
A
R
-
I
V
A
-----------
T
G
R
-----------
S
D
Y
P
N
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
S
I
V
E
E
P
S
----------------
E
E
N
I
I
P
S
P
L
N
P
I
-
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
E
G
V
A
R
T
K
--
V
--
K
G
E
W
V
E
E
H
T
I
R
------
L
I
E
F
Y
E
N
V
I
A
P
I
N
K
K
R
R
E
Y
29
HHSearch
85.23
45%
-90
- C3 -
2DVM
3
?
A:
[2-428]
-----------------
I
R
E
K
A
L
E
F
H
K
N
N
F-
P
G
N
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
---
I
A
R
D
P
G
K
V
Y
E
Y
-
T
S
K
--
G
-------------
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
G
L
-
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
D
---
A
-----
F
P
----
I
M
I
----
K
E
Q
------
E
-------------------------
P
N
K
------
F
I
D
I
V
K
-
A
-
I
A
P
T
F
G
G
I
N
L
E
D
I
A
S
P
K
C
F
-
Y
I
L
E
R
L
R
E
E
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
--
G
F
A
T
L
R
I
L
--------
T
E
----
A
----
G
V
--
K
PEN
V
R
-
V
V
E
L
V
N
G
K
P
R
I
L
T
S
D
L
D
L
E
K
-
L
-------
F
P
Y
R
---------
G
W
L
L
K
K
--------
T
----
N
GEN
I
E
-
G
---
G
P
Q
E
A
L
K
--
D
--
A
D
--
V
L
I
S
F
T
--
R
PG
P
G
V
I
K
P
Q
W
I
E
K
---
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
---
P
E
E
A
K
K
A
-
G
-
A
R
-
I
V
A
-----------
T
G
R
-----------
S
D
Y
P
N
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
S
I
V
E
E
P
----------------
S
E
E
N
I
I
P
S
P
L
N
P
I
-
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
E
G
V
A
R
T
K
--
V
----
K
G
-
E
W
V
E
E
H
------
T
I
R
L
I
E
F
Y
E
N
V
I
A
P
I
N
K
K
R
21
PsiBlast_CBE
84.46
43%
-87
- C3 -
2DVM
2
?
D:
[3-432]
------------------
R
E
K
A
L
E
F
H
K
N
N
FP
G
N
-
G
K
I
E
V
I
P
K
V
S
L
E
S
-
R
E
E
L
T
L
A
Y
T
P
G
V
A
E
P
C
K
E
---
I
A
R
D
P
G
K
V
Y
E
Y
-
T
S
K
--
G
-------------
N
L
V
A
V
V
S
D
G
S
R
I
L
G
L
G
N
I
G
P
L
A
G
L
-
P
V
M
E
G
K
A
L
L
F
K
R
F
G
G
V
D
---
A
-----
F
P
----
I
M
I
----
K
E
Q
------
E
-------------------------
P
N
K
------
F
I
D
I
V
K
-
A
-
I
A
P
T
F
G
G
I
N
L
E
D
I
A
S
P
K
C
F
-
Y
I
L
E
R
L
R
E
E
L
D
I
P
V
F
H
D
D
Q
Q
G
T
A
A
V
V
L
A
G
L
L
N
A
L
K
V
V
G
K
K
I
S
E
I
T
L
A
L
F
G
A
G
A
A
--
G
F
A
T
L
R
I
L
--------
T
E
----
A
----
G
V
--
K
PE----
N
V
R
V
V
E
L
V
N
G
K
P
R
I
L
T
S
--
D
-
L
-------
D
L
E
K
LFPYRGWLL
K
K
T
N
G
E
--------
N
----
I
----
E
-
G
---
G
P
Q
E
A
L
K
--
D
--
A
D
--
V
L
I
S
F
T
RP
G
--
P
G
V
I
K
P
Q
W
I
E
K
---
M
N
---
E
---
D
A
I
V
F
P
L
A
N
P
V
P
--
E
I
L
---
P
E
E
A
K
K
A
G
--
A
R
-
I
V
A
-----------
T
G
R
-----------
S
D
Y
P
N
Q
I
N
N
L
L
G
F
P
G
I
F
R
G
A
L
D
V
R
A
R
T
I
T
D
S
M
I
I
A
A
A
K
A
I
A
S
I
V
E
E
P
S
----------------
E
E
N
I
I
P
S
P
L
N
P
I
-
V
Y
A
R
E
A
R
A
V
A
E
E
A
M
K
E
G
V
A
R
T
K
--
V
--
K
G
E
W
V
E
E
H
T
I
R
------
L
I
E
F
Y
E
N
V
I
A
P
I
N
K
K
R
R
E
Y
30
HHSearch
79.76
36%
-85
- C3 -
3NV9
16
?
A:
[19-462]
----
L
S
Q
E
Q
R
A
V
A
K
T
Q
F
Y
K
E
L
A
E
K
V
H
K
-
F
---
Y
K
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
---
I
R
D
N
N
D
S
S
L
F
Y
-
S
L
R
--
G
-------------
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
G
L
-
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
D
---
A
-----
V
P
----
I
C
I
----
D
S
K
NKEGKN
D
-------------------------
P
D
A
------
V
I
E
F
V
Q
-
R
-
I
Q
H
T
F
G
A
I
N
L
E
D
I
S
Q
P
N
C
Y
-
K
I
L
D
V
L
R
E
S
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
--
N
T
T
C
L
R
L
I
--------
V
T
----
A
----
G
A
--
D
PK----
K
I
V
M
F
D
S
K
G
S
L
H
N
G
R
E
D
----
I
-------
K
K
D
T
---------
R
F
Y
R
K
W
E
I
C
E
T
TNP
S
----
K
----
F
-
G
---
S
I
A
E
A
C
V
--
G
--
A
D
--
V
L
I
S
L
S
--
T
PG
P
G
V
V
K
A
E
W
I
K
S
---
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
---
P
Y
E
A
K
E
-
A
G
-
A
Y
-
I
V
A
-----------
T
G
R
-----------
G
D
F
P
N
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
E
F
A
E
K
R
G
--------------
I
N
P
D
N
I
I
G
T
M
D
E
P
G
-
I
F
P
K
E
A
A
D
V
A
M
Q
A
I
K
D
G
V
A
R
V
T
--
D
--
L
-
T
W
-
Q
Q
V
Y
D
I
------
A
E
H
D
I
K
E
A
R
E
S
A
Q
L
L
Q
D
S
K
6
PsiBlast_PDB
79.54
36%
-89
- C3 -
3NV9
14
?
A:
[45-460]
----------------------------------
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
---
I
R
D
N
N
D
S
S
L
F
Y
-
S
L
R
--
G
-------------
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
G
L
-
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
D
---
A
-----
V
P
----
I
C
I
----
D
S
K
------
N
-------------------------
K
E
G
KND
P
D
A
V
I
E
F
V
Q
-
R
-
I
Q
H
T
F
G
A
I
N
L
E
D
I
S
Q
P
N
C
Y
-
K
I
L
D
V
L
R
E
S
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
--
N
T
T
C
L
R
L
I
--------
V
T
----
A
----
G
A
DP
K
------
K
I
V
M
F
D
S
K
G
S
L
H
N
G
R
-
E
--
D
-
I
KKDTRF
Y
R
K
W
E
---------
I
C
E
T
T
N
P-------
S
----
K
----
F
-
G
---
S
I
A
E
A
C
V
--
G
--
A
D
--
V
L
I
S
L
S
TP
G
--
P
G
V
V
K
A
E
W
I
K
S
---
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
---
P
Y
E
A
K
E
A
G
A
--
Y
-
I
V
A
-----------
T
G
R
-----------
G
D
F
P
N
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
E
F
A
--------------
E
K
R
G
I
N
P
D
N
I
I
G
T
M
D
E
P
G
-
I
F
P
K
E
A
A
D
V
A
M
Q
A
I
K
D
G
V
A
R
V
T
--
D
--
L
-
T
W
-
Q
Q
V
Y
D
I
------
A
E
H
D
I
K
E
A
R
E
S
A
Q
L
L
Q
D
S
K
28
PsiBlast_CBE
78.87
36%
-87
* C3 *
3NV9
13
?
B:
[45-460]
----------------------------------
G
K
I
Q
I
M
P
K
C
T
L
A
G
-
F
N
W
F
N
A
Y
Y
T
P
G
V
S
R
I
S
T
N
---
I
R
D
N
N
D
S
S
L
F
Y
-
S
L
R
--
G
-------------
N
F
V
G
V
V
S
D
S
T
R
V
L
G
D
G
D
V
T
P
P
G
G
L
-
G
V
M
E
G
K
A
L
L
M
K
Y
L
G
G
I
D
---
A
-----
V
P
----
I
C
I
----
D
S
K
------
N
-------------------------
K
E
G
KNDPDA
V
I
E
F
V
Q
-
R
-
I
Q
H
T
F
G
A
I
N
L
E
D
I
S
Q
P
N
C
Y
-
K
I
L
D
V
L
R
E
S
C
D
I
P
V
W
H
D
D
Q
Q
G
T
A
S
V
T
L
A
G
L
L
N
A
L
K
L
V
K
K
D
I
H
E
C
R
M
V
F
I
G
A
G
S
S
--
N
T
T
C
L
R
L
I
--------
V
T
----
A
----
G
A
DP
K
------
K
I
V
M
F
D
S
K
G
S
L
H
N
G
R
-
E
--
D
-
I
KKDTRFY
R
K
W
E
---------
I
C
E
T
T
N
P-------
S
----
K
----
F
-
G
---
S
I
A
E
A
C
V
--
G
--
A
D
--
V
L
I
S
L
S
TP
G
--
P
G
V
V
K
A
E
W
I
K
S
---
M
G
---
E
---
K
P
I
V
F
C
C
A
N
P
V
P
--
E
I
Y
---
P
Y
E
A
K
E
A
G
A
--
Y
-
I
V
A
-----------
T
G
R
-----------
G
D
F
P
N
Q
V
N
N
S
V
G
F
P
G
I
L
K
G
A
L
I
V
R
A
R
K
I
T
D
N
M
A
I
A
A
S
R
A
L
A
E
F
A
--------------
E
K
R
G
I
N
P
D
N
I
I
G
T
M
D
E
P
G
-
I
F
P
K
E
A
A
D
V
A
M
Q
A
I
K
D
G
V
A
R
V
T
--
D
--
L
-
T
W
-
Q
Q
V
Y
D
I
------
A
E
H
D
I
K
E
A
R
E
S
A
Q
L
L
Q
D
S
K
27
PsiBlast_CBE
78.13
46%
-96
- C3 -
2HAE
1
?
B:
[4-357]
--------------
D
A
L
E
L
H
R
F
L
K
G
K
I
R
---------
T
A
L
P
V
E
K
V
D
R
-
E
-
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
---
C
A
E
D
P
E
K
T
Y
V
Y
-
T
S
R
--
W
-------------
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
A
L
-
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
D
---
A
-----
F
P
----
I
C
L
----
S
E
S
------
E
-------------------------
E
E
K
------
I
I
S
I
V
K
-
S
-
L
E
P
S
F
G
G
I
N
L
E
D
I
G
A
P
K
C
F
-
R
I
L
Q
R
L
S
E
E
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
--
G
Y
N
I
V
K
F
L
--------
L
D
----
L
----
G
V
--
K
------
N
V
V
A
V
D
R
K
G
I
L
N
E
N
D
P
E
--
T
C
L
-------
N
E
Y
-----------
E
I
A
R
I
--------
T
----
N
P---
E
-
R
LSG
D
L
E
T
A
L
E
--
G
--
A
D
--
F
F
I
G
V
S
--
R
--
G
N
I
L
K
P
E
W
I
K
K
---
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
---
P
E
L
A
R
E
A
G
A
--
F
-
I
V
A
-----------
T
G
R
-----------
S
D
H
P
N
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
I
T
K
N
-
M
L
L
S
A
V
E
A
I
A
R
-
S
C
E
P
E
P
E
R
I
I
P
E
A
F
D
M
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
-------------------------------------------------------------------
34
HHSearch
77.33
47%
-96
- C3 -
2A9F
1
?
A:
[3-388]
-------------
L
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
----
F
G
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
---
I
A
K
D
K
T
L
A
Y
D
L
-
T
T
K
--
K
-------------
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
A
M
-
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
D
---
A
-----
I
P
----
I
V
L
----
D
T
K
------
D
-------------------------
T
E
E
------
I
I
S
I
V
K
-
A
-
L
A
P
T
F
G
G
I
N
L
E
D
I
S
A
P
R
C
F
-
E
I
E
Q
R
L
I
K
E
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
--
G
L
S
I
T
R
K
L
--------
L
A
----
A
----
G
A
--
T
------
K
V
T
V
V
D
K
F
G
I
I
N
E
Q
E
A
A
--
Q
-
L
-------
A
P
------------
D
I
A
K
V
T
N
RE----
F
----
K
----
S
-
G
---
T
L
E
D
A
L
E
--
G
--
A
D
--
I
F
I
G
V
S
--
A
--
P
G
V
L
K
A
E
W
I
S
K
---
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
---
P
D
E
A
L
E
A
-
G
-
A
Y
-
I
V
G
-----------
T
G
R
-----------
S
D
F
P
N
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
S
L
V
P
D
D
A
--------------
L
S
T
T
N
I
I
P
D
A
F
K
E
G
-
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-------------------------------------------------
25
PsiBlast_CBE
77.07
46%
-98
- C3 -
2HAE
1
?
D:
[4-357]
--------------
D
A
L
E
L
H
R
F
L
K
G
K
I
R
---------
T
A
L
P
V
E
K
V
D
R
-
E
-
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
---
C
A
E
D
P
E
K
T
Y
V
Y
-
T
S
R
--
W
-------------
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
A
L
-
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
D
---
A
-----
F
P
----
I
C
L
----
S
E
S
------
E
-------------------------
E
E
K
------
I
I
S
I
V
K
-
S
-
L
E
P
S
F
G
G
I
N
L
E
D
I
G
A
P
K
C
F
-
R
I
L
Q
R
L
S
E
E
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
--
G
Y
N
I
V
K
F
L
--------
L
D
----
L
----
G
V
--
K
------
N
V
V
A
V
D
R
K
G
I
L
N
E
N
D
P
E
--
T
C
L
-------
N
E
Y
-----------
E
I
A
R
I
--------
T
----
N
P---
E
-
R
LSG
D
L
E
T
A
L
E
--
G
--
A
D
--
F
F
I
G
V
S
--
R
--
G
N
I
L
K
P
E
W
I
K
K
---
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
---
P
E
L
A
R
E
A
G
A
--
F
-
I
V
A
-----------
T
G
R
-----------
S
D
H
P
N
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
I
T
K
N
-
M
L
L
S
A
V
E
A
I
A
R
-
S
C
E
P
E
P
E
R
I
I
P
E
A
F
D
M
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
-------------------------------------------------------------------
4
PsiBlast_PDB
76.98
46%
-95
- C3 -
2HAE
1
?
A:
[4-357]
--------------
D
A
L
E
L
H
R
F
L
K
G
K
I
R
---------
T
A
L
P
V
E
K
V
D
R
-
E
-
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
---
C
A
E
D
P
E
K
T
Y
V
Y
-
T
S
R
--
W
-------------
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
A
L
-
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
D
---
A
-----
F
P
----
I
C
L
----
S
E
S
------
E
-------------------------
E
E
K
------
I
I
S
I
V
K
-
S
-
L
E
P
S
F
G
G
I
N
L
E
D
I
G
A
P
K
C
F
-
R
I
L
Q
R
L
S
E
E
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
--
G
Y
N
I
V
K
F
L
--------
L
D
----
L
----
G
V
--
K
------
N
V
V
A
V
D
R
K
G
I
L
N
E
N
D
P
E
--
T
C
L
-------
N
E
Y
-----------
E
I
A
R
I
--------
T
----
N
P---
E
-
R
L
S
G
D
L
E
T
A
L
E
--
G
--
A
D
--
F
F
I
G
V
S
--
R
--
G
N
I
L
K
P
E
W
I
K
K
---
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
---
P
E
L
A
R
E
A
G
A
--
F
-
I
V
A
-----------
T
G
R
-----------
S
D
H
P
N
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
I
T
K
N
-
M
L
L
S
A
V
E
A
I
A
R
-
S
C
E
P
E
P
E
R
I
I
P
E
A
F
D
M
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
-------------------------------------------------------------------
26
PsiBlast_CBE
76.05
46%
-97
- C3 -
2HAE
1
?
C:
[4-357]
--------------
D
A
L
E
L
H
R
F
L
K
G
K
I
R
---------
T
A
L
P
V
E
K
V
D
R
-
E
-
T
L
S
L
L
Y
T
P
G
V
A
D
V
A
R
A
---
C
A
E
D
P
E
K
T
Y
V
Y
-
T
S
R
--
W
-------------
N
T
V
A
V
V
S
D
G
S
A
V
L
G
L
G
N
I
G
P
Y
G
A
L
-
P
V
M
E
G
K
A
F
L
F
K
A
F
A
D
I
D
---
A
-----
F
P
----
I
C
L
----
S
E
S
------
E
-------------------------
E
E
K
------
I
I
S
I
V
K
-
S
-
L
E
P
S
F
G
G
I
N
L
E
D
I
G
A
P
K
C
F
-
R
I
L
Q
R
L
S
E
E
M
N
I
P
V
F
H
D
D
Q
Q
G
T
A
V
V
V
S
A
A
F
L
N
A
L
K
L
T
E
K
K
I
E
E
V
K
V
V
V
N
G
I
G
A
A
--
G
Y
N
I
V
K
F
L
--------
L
D
----
L
----
G
V
--
K
------
N
V
V
A
V
D
R
K
G
I
L
N
E
N
D
P
E
--
T
C
L
-------
N
E
Y
-----------
E
I
A
R
I
--------
T
----
N
P---
E
-
R
LSG
D
L
E
T
A
L
E
--
G
--
A
D
--
F
F
I
G
V
S
--
R
--
G
N
I
L
K
P
E
W
I
K
K
---
M
S
---
R
---
K
P
V
I
F
A
L
A
N
P
V
P
--
E
I
D
---
P
E
L
A
R
E
A
G
A
--
F
-
I
V
A
-----------
T
G
R
-----------
S
D
H
P
N
Q
V
N
N
L
L
A
F
P
G
I
M
K
G
A
V
E
K
R
S
K
I
T
K
N
-
M
L
L
S
A
V
E
A
I
A
R
-
S
C
E
P
E
P
E
R
I
I
P
E
A
F
D
M
K
V
H
L
N
V
Y
T
A
V
K
G
S
A
-------------------------------------------------------------------
49
Fugue
75.94
46%
-90
- C3 -
2A9F
1
?
A:
[3-388]
-------------
L
K
N
Q
L
G
Q
L
A
L
E
Q
A
K
T
F
--
G
--
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
---
I
A
K
D
K
T
L
A
Y
D
L
-
T
T
K
--
K
-------------
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
A
M
-
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
D
---
A
-----
I
P
----
I
V
L
----
D
T
K
------
D
-------------------------
T
E
E
------
I
I
S
I
V
K
-
A
-
L
A
P
T
F
G
G
I
N
L
E
D
I
S
A
P
R
C
F
-
E
I
E
Q
R
L
I
K
E
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
--
G
L
S
I
T
R
K
L
--------
L
A
----
A
----
G
A
--
T
------
K
V
T
V
V
D
K
F
G
I
I
N
E
Q
E
A
A
--
Q
-
L
-------
A
P
D
I
---------
A
K
V
T
N
R
E-------
F
----
K
----
S
-
G
---
T
L
E
D
A
L
E
--
G
--
A
D
--
I
F
I
G
V
S
--
A
--
P
G
V
L
K
A
E
W
I
S
K
---
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
---
P
D
E
A
L
E
A
G
A
--
Y
-
I
V
G
-----------
T
G
R
-----------
S
D
F
P
N
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
S
L
V
P
D
D
--------------
A
L
S
T
T
N
I
I
P
D
A
F
K
E
G
-
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-------------------------------------------------
2
PsiBlast_PDB
75.59
46%
-96
- C3 -
2A9F
1
?
A:
[20-383]
----------------------------------
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
---
I
A
K
D
K
T
L
A
Y
D
L
-
T
T
K
--
K
-------------
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
A
M
-
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
D
---
A
-----
I
P
----
I
V
L
----
D
T
K
------
D
-------------------------
T
E
E
------
I
I
S
I
V
K
-
A
-
L
A
P
T
F
G
G
I
N
L
E
D
I
S
A
P
R
C
F
-
E
I
E
Q
R
L
I
K
E
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
--
G
L
S
I
T
R
K
L
--------
L
A
----
A
----
G
A
--
T
------
K
V
T
V
V
D
K
F
G
I
I
N
E
Q
E
A
A
--
Q
-
L
-------
A
P
------------
D
I
A
K
V
--------
T
N
REF
K
----
S
-
G
---
T
L
E
D
A
L
E
--
G
--
A
D
--
I
F
I
G
V
S
--
A
--
P
G
V
L
K
A
E
W
I
S
K
---
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
---
P
D
--
E
A
L
E
A
-
G
A
Y
I
V
G
-----------
T
G
R
-----------
S
D
F
P
N
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
S
L
----
V
P
D
D
----------
A
L
S
T
T
N
I
I
P
D
A
F
K
E
G
-
V
A
E
I
V
A
K
S
V
R
S
V
V
L
-------------------------------------------------
24
PsiBlast_CBE
74.63
46%
-89
- C3 -
2A9F
1
?
B:
[20-383]
----------------------------------
G
K
L
E
V
Q
P
K
V
D
I
K
T
-
K
H
D
L
S
I
A
Y
T
P
G
V
A
S
V
S
S
A
---
I
A
K
D
K
T
L
A
Y
D
L
-
T
T
K
--
K
-------------
N
T
V
A
V
I
S
D
G
T
A
V
L
G
L
G
D
I
G
P
E
A
A
M
-
P
V
M
E
G
K
A
A
L
F
K
A
F
A
G
V
D
---
A
-----
I
P
----
I
V
L
----
D
T
K
------
D
-------------------------
T
E
E
------
I
I
S
I
V
K
-
A
-
L
A
P
T
F
G
G
I
N
L
E
D
I
S
A
P
R
C
F
-
E
I
E
Q
R
L
I
K
E
C
H
I
P
V
F
H
D
D
Q
H
G
T
A
I
V
V
L
A
A
I
F
N
S
L
K
L
L
K
K
S
L
D
E
V
S
I
V
V
N
G
G
G
S
A
--
G
L
S
I
T
R
K
L
--------
L
A
----
A
----
G
A
--
T
------
K
V
T
V
V
D
K
F
G
I
I
N
E
Q
E
A
A
--
Q
-
L
-------
A
P
------------
D
I
A
K
V
--------
T
NREF
K
----
S
-
G
---
T
L
E
D
A
L
E
--
G
--
A
D
--
I
F
I
G
V
S
--
A
--
P
G
V
L
K
A
E
W
I
S
K
---
M
A
---
A
---
R
P
V
I
F
A
M
A
N
P
I
P
--
E
I
Y
---
P
D
--
E
A
L
E
A
-
G
A
Y
I
V
G
-----------
T
G
R
-----------
S
D
F
P
N
Q
I
N
N
V
L
A
F
P
G
I
F
R
G
A
L
D
A
R
A
K
T
I
T
V
E
M
Q
I
A
A
A
K
G
I
A
S
L
----
V
P
D
D
----------
A
L
S
T
T
N
I
I
P
D
A
F
K
E
G
-
V
A
E
I
V
A
K
S
V
R
S
----------------------------------------------------
33
HHSearch
73.94
26%
-98
- C3 -
1GQ2
3
MAOX_COLLI
A:
[78-529]
-------------------------------------------
L
T
S
D
I
E
R
F
M
P
I
V
Y
T
P
T
V
G
L
A
C
Q
H
Y
GL
A
F
R
R
P
R
G
L
F
I
T
I
H
D
R
--
G
H
I
A
T
M
L
Q
S
WPESV
I
K
A
I
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
C
Y
-
G
M
-
G
I
P
V
G
K
L
A
L
Y
T
A
C
G
G
V
K
PHQ
C
-----
L
P
----
V
M
L
DVGT
D
N
E
T
L
L
K
--
D
PLYIGLRH
K
R
I
R
G
Q
A
Y
D
D
L
------
L
D
E
------
F
M
E
A
V
T
-
S
R
Y
G
M
N
C
-
L
I
Q
F
E
D
F
A
N
A
N
A
F
-
R
L
L
H
K
Y
R
N
K
--
Y
C
T
F
N
D
D
I
Q
G
T
A
S
V
A
V
A
G
L
L
A
A
L
R
I
T
K
N
R
L
S
D
H
T
V
L
F
Q
G
A
G
E
A
--
A
L
G
I
A
N
L
I
--------
V
M
----
A
M
Q
K
E
G
V
--
S
K
E
E
A
I
K
R
I
W
M
V
D
S
K
G
L
I
V
K
G
R
A
S
----
L
-------
T
P
E
K
---------
E
H
F
A
H
E
--------
H
C---
E
----
M
-
K
---
N
L
E
D
I
V
K
--
D
IK
P
T
--
V
L
I
G
V
A
--
A
I-
G
G
A
F
T
Q
Q
I
L
Q
D
---
M
A
A
FN
K
---
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
T
---
A
E
Q
L
Y
K
Y
T
E
G
R
G
-
I
F
A
-----------
S
G
S
P
F
D
P
VTLPSG
Q
T
L
Y
P
G
Q
G
N
N
S
Y
V
F
P
G
V
A
L
G
V
I
S
C
G
L
K
H
I
G
D
D
V
F
L
T
T
A
E
V
I
A
Q
E
V
S
E
E
N
--------------
L
Q
E
G
R
L
Y
P
P
L
V
T
I
Q
Q
V
S
L
K
I
A
V
R
I
A
K
E
A
Y
R
N
N
T
A
S
T
Y
PQ
P
--
E
-
D
L
-
E
A
F
I
R
S
------
Q
V
Y
S
T
D
Y
N
C
F
V
A
D
S
Y
T
W
P
E
32
HHSearch
71.27
24%
-95
- C3 -
1PJ3
6
MAOM_HUMAN
A:
[85-533]
------------------------------------------------
E
S
L
M
P
I
V
Y
T
P
T
V
G
L
A
C
S
Q
Y
GH
I
F
R
R
P
K
G
L
F
I
S
I
S
D
R
--
G
H
V
R
S
I
V
D
N
WPENH
V
K
A
V
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
V
Y
-
G
M
-
G
I
P
V
G
K
L
C
L
Y
T
A
C
A
G
I
R
PDR
C
-----
L
P
V
C
I
D
V
G
T
----
D
N
I
A
L
L
K
--
D
PFYMGLYQKRDRTQ
Q
Y
D
D
L
------
I
D
E
------
F
M
K
A
I
T
-
D
R
Y
G
R
N
T
-
L
I
Q
F
E
D
F
G
N
H
N
A
F
-
R
F
L
R
K
Y
R
E
K
--
Y
C
T
F
N
D
D
I
Q
G
T
A
A
V
A
L
A
G
L
L
A
A
Q
K
V
I
S
K
P
I
S
E
H
K
I
L
F
L
G
A
G
E
A
--
A
L
G
I
A
N
L
I
--------
V
M
----
S
M
V
E
N
G
L
--
S
E
Q
E
A
Q
K
K
I
W
M
F
D
K
Y
G
L
L
V
K
G
R
K
A
--
K
-
I
-------
D
S
Y
Q
---------
E
P
F
T
H
S
--------
A
PES-
I
----
P
-
D
---
T
F
E
D
A
V
N
I
L
K
--
P
S
--
T
I
I
G
V
A
--
G
A-
G
R
L
F
T
P
D
V
I
R
A
---
M
A
---
S
I
N
E
R
P
V
I
F
A
L
S
N
P
T
A
QA
E
C
T
---
A
E
E
A
Y
T
L
T
E
G
R
C
-
L
F
A
-----------
S
G
S
P
F
G
P
VKLTDG
R
V
F
T
P
G
Q
G
N
N
V
Y
I
F
P
G
V
A
L
A
V
I
L
C
N
T
R
H
I
S
D
S
V
F
L
E
A
A
K
A
L
T
S
Q
L
T
D
E
E
--------------
L
A
Q
G
R
L
Y
P
P
L
A
N
I
Q
E
V
S
I
N
I
A
I
K
V
T
E
Y
L
Y
A
N
K
M
A
F
R
Y
PE
P
--
E
-
D
K
-
A
K
Y
V
K
E
------
R
T
W
R
S
E
Y
D
S
L
L
P
D
V
Y
E
W
P
-
31
HHSearch
71.07
26%
-99
- C3 -
1O0S
2
MAOM_ASCSU
A:
[119-586]
------------------------------------------------
K
E
L
M
P
I
V
Y
T
P
T
V
G
L
A
C
Q
N
FG
Y
I
Y
R
K
P
K
G
L
Y
I
T
I
N
D
N
S
V
S
K
I
Y
Q
I
L
S
N
WHEED
V
R
A
I
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
A
Y
-
G
I
-
G
I
P
V
G
K
L
A
L
Y
V
A
L
G
G
V
Q
PKW
C
-----
L
P
V
L
L
D
V
G
T
----
N
N
M
D
L
L
N
--
D
PFYIGLRH
K
R
V
R
G
K
D
Y
D
T
L
------
L
D
N
------
F
M
K
A
C
T
K
K
-
Y
G
Q
K
T
-
L
I
Q
F
E
D
F
A
N
P
N
A
F
-
R
L
L
D
K
Y
Q
D
K
--
Y
T
M
F
N
D
D
I
Q
G
T
A
S
V
I
V
A
G
L
L
T
C
T
R
V
T
K
K
L
V
S
Q
E
K
Y
L
F
F
G
A
G
A
A
--
S
T
G
I
A
E
M
I
--------
V
H
Q
M
Q
N
E
----
G
I
--
S
K
E
E
A
C
N
R
I
Y
L
M
D
I
D
G
L
V
T
K
N
R
K
E
----
M
-------
N
P
R
H
---------
V
Q
F
A
K
D
--------
M
P
---
E
----
T
-
T
---
S
I
L
E
V
I
R
--
A
A
R
P
G
--
A
L
I
G
A
S
--
T
V-
R
G
A
F
N
E
E
V
I
R
A
---
M
A
---
E
I
N
E
R
P
I
I
F
A
L
S
N
P
T
S
KA
E
C
T
---
A
E
E
A
Y
T
F
T
N
G
A
A
-
L
Y
A
-----------
S
G
S
P
F
P
N
FELNG
H
-
T
Y
K
P
G
Q
G
N
N
A
Y
I
F
P
G
V
A
L
G
T
I
L
F
Q
I
R
H
V
D
N
D
L
F
L
L
A
A
K
K
V
A
S
C
V
T
E
D
S
--------------
L
K
V
G
R
V
Y
P
Q
L
K
E
I
R
E
I
S
I
Q
I
A
V
E
M
A
K
Y
C
Y
K
N
G
T
A
N
L
Y
--
P
QP
E
-
D
L
-
E
K
Y
V
R
A
Q
VYNTE
Y
E
E
L
I
N
A
T
Y
D
W
P
E
Q
D
M
R
H
G
8
PsiBlast_PDB
61.60
27%
-93
- C3 -
1GQ2
3
MAOX_COLLI
A:
[137-479]
--------------------------------------------------------------------------------------------------------
V
V
T
D
G
E
R
I
L
G
L
G
D
L
G
C
Y
G
M
G
I
P
V
--
G
K
L
A
L
Y
T
A
C
G
G
V
K
---
P
HQ
C
L
P
V
M
----
L
D
V
----
G
T
D
------
N
E
T
L
L
K
DPLYIGLRH
K
R
I
R
G
Q
A
Y
D
D
L
L
D
E
------
F
M
E
A
V
T
-
S
-
R
Y
G
M
N
C
L
I
Q
F
E
D
F
A
N
A
N
A
F
R
L
L
H
K
Y
R
N
K
Y
C
---
T
F
N
D
D
I
Q
G
T
A
S
V
A
V
A
G
L
L
A
A
L
R
I
T
K
N
R
L
S
D
H
T
V
L
F
Q
G
A
G
E
A
A
L
G
I
A
N
L
I
V
M
A
M
Q
K
E
GVS
K
E
----
E
----
A
I
--
K
------
R
I
W
M
V
D
S
K
G
L
I
V
K
G
R
-
A
--
S
-
L
-------
T
P
E
K
---------
E
H
F
A
H
E
--------
H
----
C
----
E
M
K
---
N
L
E
D
I
V
K
--
D
--
I
K
PT
V
L
I
G
V
A
--
A
I-
G
G
A
F
T
Q
Q
I
L
Q
D
M
A
A
F
N
---
K
---
R
P
I
I
F
A
L
S
N
P
T
S
--
K
A
E
CT
A
E
Q
L
Y
K
Y
T
E
G
-
R
G
-
I
F
A
S
G
S
P
F
D
P
VTLP
S
G
Q
-----------
T
L
Y
P
G
Q
G
N
N
S
Y
V
F
P
G
V
A
L
G
V
I
S
C
G
L
K
H
I
G
D
D
V
F
L
T
T
A
E
V
I
A
Q
E
V
S
E
E
N
L
Q
E
G
R
L
Y
P
P
L
V
T
I
Q
Q
V
S
L
K
I
A
V
R
I
A
K
E
A
-
Y
R
N
N
T
A
S
T
Y
P
Q
P
E
D
L
E
A
F
I
R
S
Q
--
V
--
Y
-
S
T
-
D
Y
N
C
F
V
------
A
D
S
Y
T
W
P
E
E
A
M
K
V
K
-----