@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0677: (2015-12-03 )
MLVNNISYLYNNQDDFALNNINIKVKRGKVACLLGHSGCGKSTILKLIAGIENPKSGTIFINDKLVASSSTSIAIEHRNIGLIFQHSALFPHKTVVENVTFAIRSSSKKEKHLIALEILKLLNIAKYENMYPNALSGGQQQLVAIARVMAQNPDVVLLDEPFSNLDILLKCQIRQRILSLFRSKNIPVLMVTHDPQEALKVADFIYVMKNGRIIQSGISSDIYHRPKDDTLAKFFSELSSTLQLGEKFPLDGAFAVRK
Atome Classification :
(38 SA)
----.........10........20........30........40........50........60...---.....70-....-....--------80........90........100---.---.--..--.--.--.110.......120..-.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...---....240.------......250......-----------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MLVN
N
I
S
Y
L
YNNQDD
F
A
L
N
N
I
N
I
K
V
KR
G
K
V
A
C
L
LGHSGC
G
K
S
T
I
L
K
L
I
A
GIENPKS
G
T
I
F
I
ND
K
---
L
VASSS
T
-
S
I
A
I
-
E
HR
N
--------
I
G
L
I
F
QHSALFP
H
K
T
V
V
EN
V
T
F
A
---I---R--SS--S--K--KE
K
H
L
I
A
L
E
I
L
K
L
L
N
I
-
A
K
Y
ENMYPNALSG
G
Q
Q
Q
L
V
A
I
A
R
V
MAQNP
D
V
V
L
LDEPFSN
L
D
I
L
L
K
C
Q
I
R
Q
R
I
L
S
L
F
RSKNI
P
V
L
M
V
TH
D
P
Q
E
A
L
K
V
A
D
F
I
Y
V
MKN
G
R
I
IQSGISSDIYHRPKD
D
T
L
A
K
F
F
---
S
E
L
S
S
T
L
Q------LGEKFPLDGAFAVRK-----------------------------------------------------------------------------
115
Fugue
82.45
35%
-134
- C1 -
1Z47
1
?
A:
[11-355]
GSMT
I
E
F
V
G
V
E
K
I
Y
P
G
G
A
R
-
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
---
R
V
----
T
-
D
L
P
P
-
Q
K
R
N
--------
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
---
L
---
R
E
K
R
V
--
P
--
K
--
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
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F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
GE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
96
HHSearch
82.32
39%
-143
- C1 -
1V43
-
?
A:
[13-244]
----
V
K
L
E
N
L
T
K
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
---
D
V
T
Y
L
P
-----
P
-
K
D
R
N
--------
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
---
L
-------
K
--
K
FP
K
--
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
---
G
A
P
E
M
N
I
L
------
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
-----------------------------------------------------------------------------
100
HHSearch
79.44
45%
-134
- C1 -
2IT1
-
?
A:
[4-234]
----
I
K
L
E
N
I
V
K
K
F
G
N
--
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
---
D
V
T
E
L
P
-----
P
-
K
D
R
N
--------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
---
L
---
E
--
L
R
--
K
--
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
---
G
N
P
P
M
N
F
V
------
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
-----------------------------------------------------------------------------
101
HHSearch
78.65
40%
-129
- C1 -
2YYZ
3
?
A:
[4-227]
----
I
R
V
V
N
L
K
K
Y
F
G
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
---
L
V
N
D
I
P
-----
P
-
K
Y
R
E
--------
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
---
L
---
R
--
A
R
--
R
IS
K
--
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
-
D
N
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
---
G
N
P
P
T
N
F
L
------
R
D
F
S
V
S
V
E
N
K
Q
T
I
L
K
-----------------------------------------------------------------------------
9
PsiBlast_PDB
78.15
40%
-143
- C1 -
1V43
-
?
A:
[27-244]
--------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
---
D
V
----
T
-
Y
L
P
P
-
K
D
R
N
--------
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
F
P
L------
K
--
K
F
--
P
--
K
--
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
---
G
A
P
E
M
N
I
L
------
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
-----------------------------------------------------------------------------
27
PsiBlast_CBE
78.07
38%
-136
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[15-241]
----------------
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
---
T
I
F
S
K
N
T
-
N
L
P
V
-
R
E
R
R
--------
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
---
L
GNG
K
--
G
R
--
T
--
A
--
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
---
G
E
G
I
V
F
P
A
------
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
-----------------------------------------------------------------------------
94
HHSearch
77.65
36%
-135
- C1 -
1Z47
1
?
A:
[15-248]
----
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
---
R
V
T
D
L
-----
P
P
-
Q
K
R
N
--------
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
---
L
---
R
--
E
K
--
R
--
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
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V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
---
G
E
S
N
V
W
T
R
------
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
-----------------------------------------------------------------------------
26
PsiBlast_CBE
76.21
36%
-128
- C1 -
1OXU
7
?
B:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
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V
K
E
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Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
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R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
5
PsiBlast_PDB
76.19
36%
-129
- C1 -
1OXU
7
?
A:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
21
PsiBlast_CBE
76.06
45%
-138
- C1 -
2IT1
1
?
B:
[18-235]
--------------------
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
---
D
V
----
T
-
E
L
P
P
-
K
D
R
N
--------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
---
L
E
L
-
R
--
K
A
--
P
--
R
--
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
---
G
N
P
P
M
N
F
V
------
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
-----------------------------------------------------------------------------
23
PsiBlast_CBE
75.92
36%
-129
- C1 -
1OXV
15
?
D:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
11
PsiBlast_PDB
75.05
38%
-135
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[15-241]
----------------
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
---
T
I
F
S
K
N
T
-
N
L
P
V
-
R
E
R
R
--------
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
---
L
GNG
K
--
G
R
--
T
--
A
--
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
---
G
E
G
I
V
F
P
A
------
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
-----------------------------------------------------------------------------
7
PsiBlast_PDB
74.95
35%
-125
- C1 -
1OXX
22
?
K:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
24
PsiBlast_CBE
74.93
36%
-124
- C1 -
1OXV
4
?
B:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
95
HHSearch
74.79
37%
-133
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-233]
----
L
H
I
G
H
L
S
K
S
F
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
---
T
I
F
S
K
N
T
-
N
L
P
V
-
R
E
R
R
--------
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
---
L
---
G
--
N
G
--
K
GR
T
--
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
---
G
E
G
I
V
F
P
A
------
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
-----------------------------------------------------------------------------
97
HHSearch
74.73
36%
-128
- C1 -
1OXX
22
?
K:
[4-242]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
L
I
V
P
P
-
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
--
K
MS
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
1
PsiBlast_PDB
74.34
45%
-136
- C1 -
2IT1
-
?
A:
[18-235]
--------------------
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
---
D
V
----
T
-
E
L
P
P
-
K
D
R
N
--------
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
---
L
E
L
-
R
--
K
A
--
P
--
R
--
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
---
G
N
P
P
M
N
F
V
------
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
-----------------------------------------------------------------------------
25
PsiBlast_CBE
73.86
36%
-127
- C1 -
1OXU
13
?
C:
[4-246]
----
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
---
L
V
A
S
N
G
K
-
L
I
V
P
P
E
D
R
K
--------
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
---
L
---
T
--
N
M
KM
S
--
K
--
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
---
G
E
I
N
E
L
E
G
------
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
-----------------------------------------------------------------------------
2
PsiBlast_PDB
73.73
38%
-138
- C1 -
1Z47
1
?
A:
[30-248]
--------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
---
R
V
----
T
-
D
L
P
P
-
Q
K
R
N
--------
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
---
L
---
R
--
E
K
RV
P
--
K
--
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
---
G
E
S
N
V
W
T
R
------
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
-----------------------------------------------------------------------------
99
HHSearch
73.35
37%
-139
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-236]
----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
---
R
M
N
D
T
-----
P
P
-
A
E
R
G
--------
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
---
L
---
K
--
L
A
--
G
AK
K
--
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
---
G
S
P
K
M
N
F
L
------
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
-----------------------------------------------------------------------------
50
PsiBlast_CBE
64.05
33%
-131
- C1 -
4YMU
2
?
J:
[17-239]
---------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
---
K
I
N
N
G
K
V
-
N
I
N
K
-
V
R
Q
K
--------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
PVK
V
---
K
--
K
M
--
N
--
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
---
S
K
I
L
------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
63.13
32%
-129
- C1 -
3C4J
3
?
A:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
62.44
33%
-133
- C1 -
4YMU
2
?
A:
[17-239]
---------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
---
K
I
N
N
G
K
V
-
N
I
N
K
-
V
R
Q
K
--------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
PVK
V
---
K
--
K
M
--
N
--
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
---
S
K
I
L
------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
62.37
32%
-130
- C1 -
2OLK
1
?
D:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
62.30
32%
-135
- C1 -
3C4J
4
?
B:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
61.96
33%
-129
- C1 -
4YMV
1
?
A:
[17-239]
---------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
---
K
I
N
N
G
K
V
-
N
I
N
K
-
V
R
Q
K
--------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
PVK
V
---
K
--
K
M
--
N
--
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
---
S
K
I
L
------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.29
32%
-129
- C1 -
2OLJ
4
?
A:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.00
32%
-129
- C1 -
2Q0H
4
?
A:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.97
32%
-130
- C1 -
2Q0H
4
?
B:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
60.71
32%
-132
- C1 -
3C41
3
?
J:
[19-241]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
60.43
33%
-131
- C1 -
4YMV
1
?
J:
[17-239]
---------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
---
K
I
N
N
G
K
V
-
N
I
N
K
-
V
R
Q
K
--------
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
PVK
V
---
K
--
K
M
--
N
--
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
---
S
K
I
L
------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.19
32%
-128
- C1 -
2OLK
2
?
B:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
60.05
32%
-127
- C1 -
2OLK
1
?
A:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
59.88
32%
-141
- C1 -
1B0U
4
HISP_SALTY
A:
[22-253]
---------------------
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
NI
N
L
V
R
D
K
D
G
-
Q
L
K
V
-
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
PIQ
V
---
L
--
G
L
--
S
--
K
--
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
-
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
---
K
G
S
L
K
K
L
E
------
H
-------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.94
34%
-124
- C1 -
4U00
3
?
A:
[20-241]
---------------------
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
-
D
G
---
L
S
V
K
D
D
R
-
A
L
R
E
-
I
R
R
E
--------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---
R
--
R
W
--
P
--
R
--
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
---
Q
R
V
L
H
-----------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.45
32%
-133
- C1 -
3C41
3
?
K:
[19-241]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
57.05
32%
-125
- C1 -
2OLJ
3
?
B:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
56.90
32%
-130
- C1 -
2OLK
1
?
C:
[40-262]
---------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
T
-
N
L
N
K
-
V
R
E
E
--------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
PMK
V
---
R
--
K
W
--
P
--
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---
S
K
V
F
------------------------------------------------------------------------------------------------------