@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0680: (2015-12-03 )
MYVCGPTVYDTAHIGNARSIVVYDVLFQLLKFCYGKATYVRNITDIDDKIINAANEKDSSIESISTYYTRAFHEDMRSINCVEPTHEPKAAENIKYIIELIEYLLQSGHAYESNKHIYFSIESYPEYGALSGKKIDELEHGSRVEVGENKKHPGDFVLWKPANDTDYKLSSYWNSPWGEGRPGWHIECSAMSYAYLGKDFDIHGGGIDLQFPHHENEIAQNKSAFAGSMFAKYWVHNGSLTVNKEKMSKSLFNIVKVRDLLDSGIKGEVIRYALFKTHYRKPLDWTESVISESQETLNKFYRLLRGIDVASIEKSDVEVSRDFIETLKNDLNIPEALAILHEMATKINKTNNENEKLKLTESFIKSARFIGLLESSYQEWFTAGISYQEIKRLIDLRKVAKQNKDYDAADKIRDQLKQMGVTISDNEDGTTTW
Atome Classification :
(20 SA)
------------------------.........10........20........30........40.....---...50....----.-.---.-------------------------------------------.----------------60------------........70........80....--.--..--.90-.--.--.......100.......110---.-.-.----.....120....------------------...---------------------------------------------130--.-----------.-----------------------------------.-----------------------.-------.-----------------------------..-----------------------------------------------------------------------------.----------------------------------------------------------------------------------------------140.-...---------------------------------------------------------------------.------------------------------------------------.---------------------------.-------------------.---------------------150--------.--.-----.-----.---------------.-.------.-------.--------.---------------160--------.-.----------------------------------------------------..---------.....170...----....180.--------....----.-----.-------------------------------------------------------190----------------------------.------.-----------------.------------.-------.------------.----------------------.-----------.---.200.......210.......220...-----..-..--230.......240.-----------------------------------------------.-.-------.....250.......260.......270....-.--..280.......290.--.-------.--....300.......-310-----------------.-----------------.--------------------..--------....320.......330.......340...--.--...350..--....-------------.--..360.......370.......380.-----...-----...390----.........400.......410.......420.......430.---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------MYVCGPTVYDTAHIGNA
R
S
I
V
V
Y
D
V
L
F
Q
L
L
K
F
CYGK
A
T
Y
V
R
NITDI---
D
D
K
I
I
NAAN----E-K---D-------------------------------------------S----------------
S
I
------------
E
S
I
S
T
Y
Y
T
R
A
F
H
E
D
M
RSINCVEPT--H--EP--
K
A
--
A
--
E
--
N
I
K
Y
I
I
E
L
I
E
Y
L
L
QSGHAY----E-S-N----
K
H
I
Y
F
S
IESYPE------------------YGA---------------------------------------------LS---G-----------K-----------------------------------K-----------------------
I
-------
D
-----------------------------
E
L-----------------------------------------------------------------------------E----------------------------------------------------------------------------------------------H-GS-RVE---------------------------------------------------------------------V------------------------------------------------G---------------------------E-------------------N---------------------K----------K--H-----P-----G---------------
D
-
F
------
V
-------
L
--------W---------------K----------P-A----------------------------------------------------ND---------TDY
K
L
S
S
YWNS----PWGEGRPG--------
W
H
I
E
----C-----S-------------------------------------------------------A------------------------------
M
------
S
-----------------
Y
------------
A
-------
Y
------------L----------------------G-----------K---D
F
D
IHGG
G
I
D
L
QFPHH
E
N
E
I
A
Q
N
K
S
A
F
-----
A
G
-
S
M
--
F
A
K
Y
W
V
HNG
S
L
T
-V-----------------------------------------------
N
-
K
-------
E
K
M
S
K
S
L
F
N
I
V
K
V
R
D
L
L
DSGIK
G
E
V
I
R
Y
A
L
F
K
-
T
--
H
YRKPL
D
W
T
E
S
V
I
S
E
S
--
Q
-------
E
--
T
L
N
K
F
Y
R
L
L
RGIDV-A-S-----------------I-----------------E--------------------K
S
--------
D
V
E
V
S
R
D
F
I
E
T
L
K
NDLN
I
P
E
A
L
A
I
L
H
E
M
A
T
--
K
--INKT--NN--EN
E
K
-------------
L
--
K
L
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S
F
I
K
S
A
R
F
I
G
L
L
E
S
S
Y
Q
E
W
F
TA-----GI
S
-----
Y
Q
E
I
------
K
R
L
I
D
L
R
K
V
A
K
QNKDY
D
A
A
D
K
I
R
D
Q
L
K
QMG
V
T
I
SDNEDGTTTW---
49
Fugue
89.67
43%
-74
- C3 -
1U0B
1
SYC_ECOLI
B:
[1-461]
MLKIFNTLTRQKEEFKPIHAGEVG
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
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L
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Y
K
L
K
Y
V
R
N
I
T
D
I
---
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D
K
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N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
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M
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----
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M
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T
D
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------------------
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---------------------------------------------
L
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-----------------------------------
D
-----------------------
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-------
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V
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D
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D
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K
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---------------
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------
V
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L
--------
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---------
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E
----
P
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W
P
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----
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W
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--------
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----
C
-----
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-------------------------------------------------------
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---
H
F
D
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M
F
P
H
H
E
N
E
I
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Q
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T
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-----
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Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
Y
-
D
A
E
T
V
R
Y
F
L
M
S
-
G
--
H
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
--
R
-------
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--
A
L
E
R
L
Y
T
A
L
R
G
T
D
K
-
T
-
V
-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
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A
Y
S
V
L
F
D
M
A
R
--
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--
V
N
R
L
KA
E
D
--
M
A
A
A
-------------
N
--
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
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Q
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GAQAD
D
S
E
-----
V
A
E
I
------
E
A
L
I
Q
Q
R
L
D
A
R
K
A
K
D
W
A
A
A
D
A
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R
D
R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
-
T
T
W
RRK
3
PsiBlast_PDB
89.03
42%
-76
- C3 -
1U0B
1
SYC_ECOLI
B:
[25-457]
------------------------
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
K
R
A
N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
E
M
H
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D
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D
A
L
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P
D
--
M
--
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P
--
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--
H
--
H
I
A
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I
I
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L
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Q
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----
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A
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N
----
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M
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D
V
P
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T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
-----------------------------------
D
-----------------------
L
-------
D
-----------------------------
Q
L
-----------------------------------------------------------------------------
Q
----------------------------------------------------------------------------------------------
A
-
G
A
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D
---------------------------------------------------------------------
V
------------------------------------------------
V
---------------------------
D
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D
---------------------
K
----------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
V
-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
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---------
G
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----
P
S
W
P
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----
P
W
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A
G
R
P
G
--------
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H
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E
----
C
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-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
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-------
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------------
L
----------------------
G
-----------
N
---
H
F
D
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H
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G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
-----
D
G
-
Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
-
Y
D
A
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Y
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S
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G
--
H
Y
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Q
L
N
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N
L
K
Q
A
--
R
-------
A
--
A
L
E
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Y
T
A
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T
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K
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T
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V
-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
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A
R
F
I
E
A
M
D
D
D
F
N
T
P
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A
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L
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A
R
--
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V
N
R
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--
K
A
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E
D
M
A
-------------
A
AN
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
Q
S
-----
G
A
Q
ADDSE
V
A
E
I
------
E
A
L
I
Q
Q
R
L
D
A
R
K
A
K
D
W
A
A
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D
A
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R
D
R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
T
T
W
R
---
50
Fugue
88.35
44%
-83
- C3 -
1LI5
1
SYC_ECOLI
A:
[1-402]
MLKIFNTLTRQKEEFKPIHAG
E
V
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
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---
D
D
K
I
I
K
R
A
N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
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M
H
K
D
F
D
A
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N
I
L
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--
M
--
E
P
--
R
A
--
T
--
H
--
H
I
A
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I
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T
E
Q
L
I
A
K
G
H
A
Y
----
V
-
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
-----------------------------------
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
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-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
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---------
G
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----
P
S
W
P
S
----
P
W
G
A
G
R
P
G
--------
W
H
I
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----
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-----
S
-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
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-------
Q
------------
L
----------------------
G
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N
---
H
F
D
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H
G
G
G
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M
F
P
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Q
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T
C
A
H
-----
D
G
-
Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
-
Y
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A
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R
Y
F
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M
S
-
G
--
H
Y
R
S
Q
L
N
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S
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E
N
L
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Q
A
--
R
-------
A
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A
L
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Y
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A
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D
K
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T
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-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
--
E
--
V
N
R
L
--
K
A
E
D
M
A
A
A
-------------
N
--
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
-----------------------------------------------------------------------
27
HHSearch
85.85
44%
-88
- C3 -
1LI5
1
SYC_ECOLI
A:
[25-402]
------------------------
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
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Y
L
R
F
L
G
Y
K
L
K
Y
V
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N
I
T
D
I
---
D
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K
I
I
K
R
A
N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
E
M
H
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D
F
D
A
L
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R
P
D
--
M
--
E
P
--
R
A
--
T
--
H
--
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I
A
E
I
I
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L
T
E
Q
L
I
A
K
G
H
A
Y
----
V
-
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
V
-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
E
---------
G
----
E
P
S
W
P
S
----
P
W
G
A
G
R
P
G
--------
W
H
I
E
----
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-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
K
-------
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------------
L
----------------------
G
-----------
N
---
H
F
D
I
H
G
G
G
S
D
L
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F
P
H
H
E
N
E
I
A
Q
S
T
C
A
------
H
D
-
G
Q
--
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
-
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
--
H
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
--
R
-------
A
--
A
L
E
R
L
Y
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A
L
R
G
T
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K
T
V
-
A
-----------------
P
--------------------------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
--
E
--
V
N
R
L
--
K
A
--
E
D
M
A
A
A
-----------
N
--
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
-----------------------------------------------------------------------
1
PsiBlast_PDB
84.95
42%
-86
- C3 -
1LI5
1
SYC_ECOLI
A:
[25-402]
------------------------
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
K
R
A
N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
--
E
P
--
R
A
--
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
----
V
-
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
V
-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
E
---------
G
E
----
P
S
W
P
S
----
P
W
G
A
G
R
P
G
--------
W
H
I
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
K
-------
Q
------------
L
----------------------
G
-----------
N
---
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
-----
D
G
-
Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
-
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
--
H
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
--
R
-------
A
--
A
L
E
R
L
Y
T
A
L
R
G
T
D
K
-
T
-
V
-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
--
E
--
V
N
R
L
--
K
A
--
E
D
M
A
-------------
A
A
N
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
-----------------------------------------------------------------------
21
PsiBlast_CBE
84.90
42%
-88
- C3 -
1LI7
2
SYC_ECOLI
B:
[25-402]
------------------------
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
K
R
--------------------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
--
E
P
--
R
A
--
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
----
V
-
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
V
-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
E
---------
G
E
----
P
S
W
P
S
----
P
W
G
A
G
R
P
G
--------
W
H
I
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
K
-------
Q
------------
L
----------------------
G
-----------
N
---
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
-----
D
G
-
Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
-----
N
F
F
T
V
R
D
V
L
K
Y
-
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
--
H
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
--
R
-------
A
--
A
L
E
R
L
Y
T
A
L
R
G
T
D
K
-
T
-
V
-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
--
E
--
V
N
R
L
--
K
A
--
E
D
M
A
-------------
A
A
N
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
-----------------------------------------------------------------------
2
PsiBlast_PDB
84.88
42%
-87
- C3 -
1LI7
2
SYC_ECOLI
A:
[25-402]
------------------------
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
K
R
A
N
----
E
-
N
---
G
-------------------------------------------
E
----------------
S
F
------------
V
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
R
P
D
--
M
--
E
P
--
R
A
--
T
--
H
--
H
I
A
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
----
V
-
A
D
N
----
G
D
V
M
F
D
V
P
T
D
P
T
------------------
Y
G
V
---------------------------------------------
L
S
---
R
-----------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------
R
--
N
-----
P
-----
M
---------------
D
-
F
------
V
-------
L
--------
W
---------------
K
----------
M
-
S
----------------------------------------------------
K
E
---------
G
E
----
P
S
W
P
S
----
P
W
G
A
G
R
P
G
--------
W
H
I
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
C
------------
K
-------
Q
------------
L
----------------------
G
-----------
N
---
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
-----
D
G
-
Q
---
Y
V
N
Y
W
M
H
S
G
M
V
M
-
V
-----------------------------------------------
D
-
R
-------
E
K
M
S
K
S
L
G
N
F
F
T
V
R
D
V
L
K
Y
-
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
--
H
Y
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
--
R
-------
A
--
A
L
E
R
L
Y
T
A
L
R
G
T
D
K
-
T
-
V
-----------------
A
-----------------
P
--------------------
A
G
--------
G
E
A
F
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
R
--
E
--
V
N
R
L
--
K
A
--
E
D
M
A
-------------
A
A
N
A
M
A
S
H
L
R
K
L
S
A
V
L
G
L
L
E
Q
E
P
E
A
F
L
-----------------------------------------------------------------------
4
PsiBlast_PDB
83.94
32%
-96
- C3 -
3SP1
2
SYC_BORBU
A:
[45-490]
------------------------
V
Y
A
C
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
GHL---------------------------------------------------------------
L
----------------
T
V
------------
Y
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
Y
P
D
--
K
--
V
L
--
V
A
--
S
--
K
--
H
I
P
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
----
F
-
S
-
N
----
G
N
V
Y
F
D
T
S
C
F
K
S
------------------
Y
G
E
---------------------------------------------
M
A
---
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---------------------
K
----------
R
--
N
-----
K
-----
T
---------------
D
-
F
------
V
-------
L
--------
W
F
T
N
------------
S
----------
K
-------------------------------------------------------------------
M
K
----
W
D
S
----
P
W
G
F
G
Y
P
S
--------
W
H
L
E
----
C
-----
A
-------------------------------------------------------
A
------------------------------
M
------
N
-----------------
L
------------
E
-------
Y
------------
F
----------------------
K
-----------
D
---
A
L
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
-
A
E
C
F
-----
L
N
-
K
K
--
W
C
D
V
F
V
H
G
E
F
L
I
-
M
-----------------------------------------------
D
------------------
F
I
T
V
K
D
L
E
D
Q
N
F
S
P
L
D
F
R
Y
L
C
L
T
-
S
--
H
Y
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
--
K
I
A
R
E
N
L
I
N
--
K
L
S
Y
F
Y
E
S
L
D
P
V
D
L
-
N
-
T
-----------------
L
-----------------
N
--------------------
K
D
LKNFGF
S
V
E
K
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
--------
I
I
K
S
--
D
N
--
L
S
F
V
-------------
S
--
K
L
R
L
A
F
I
----
F
D
E
I
M
S
L
N
L
R
E
E
I
L
K
-----
N
L
Q
-----
N
H
D
V
V
I
D
E
N
M
K
A
L
I
E
E
R
R
I
A
K
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
------------
29
HHSearch
78.21
32%
-73
- C3 -
3C8Z
7
MSHC_MYCS2
A:
[42-413]
------------------------
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
E
R
A
E
----
R
-
D
---
G
-------------------------------------------
I
----------------
D
W
------------
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
--
Y
V
--
A
A
--
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
----
I
-
V
-
E
DAEY
P
D
V
Y
F
R
A
D
A
T
A
Q
------------------
F
G
Y
---------------------------------------------
E
S
---
G
-----------
Y
-----------------------------------
D
-----------------------
R
-------
D
-----------------------------
T
M
-----------------------------------------------------------------------------
L
T
L
F
A
E
R
----------------------------------------------------------------------------------------
G
-
G
D
-
P
D
-----------------------------------------------------------------------------------------------------------------------
R
---------------------------
P
-------------------
G
---------------------
K
----------
S
--
D
-----
Q
-----
L
---------------
D
-
A
------
L
-------
L
--------
W
---------------
R
----------
A
-
E
----------------------------------------------------
R
P
---------
G
----
E
P
S
W
P
S
----
P
F
G
R
G
R
P
G
--------
W
H
V
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
I
------
A
-----------------
L
------------
T
-------
R
------------
I
----------------------
G
-----------
T
---
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
------
T
G
E
R
R
--
F
A
R
H
Y
V
H
T
G
M
I
G
---------------------------------------------------------------------
V
L
V
S
Q
L
R
A
Q
G
V
D
P
S
A
I
R
L
G
L
F
S
-
G
--
H
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
--
N
-------
A
--
R
L
A
R
W
R
S
A
T
A
L
P
E
A
------------------------------------------------------------
P
D
--------
A
T
D
V
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
--
D
--
A
L
S
Y
--
G
G
--
H
D
T
--------------
E
--
S
P
R
L
V
A
T
T
V
D
A
L
L
G
V
D
L
------------------------------------------------------------------------------
22
PsiBlast_CBE
76.01
31%
-67
- C3 -
3C8Z
5
MSHC_MYCS2
B:
[42-408]
------------------------
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
E
R
A
E
----
R
-
D
---
G
-------------------------------------------
I
----------------
D
W
------------
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
--
Y
V
--
A
A
--
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
ED
A
-
E
-
Y
----
P
D
V
Y
F
R
A
D
A
T
A
Q
------------------
F
G
Y
---------------------------------------------
E
S
---
G
-----------
Y
-----------------------------------
D
-----------------------
R
-------
D
-----------------------------
T
M
-----------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
T
--
L
-
F
A
E
---------------------------------------------------------------------
R
------------------------------------------------
G
---------------------------
G
-------------------
D
---------------------
P
----------
D
--
R
-----
P
-----
G
KSDQL----------
D
-
A
------
L
-------
L
--------
W
---------------
R
----------------------------------------------------------------------------
A
E
R
P
G
E
P
S
W
P
S
----
P
F
G
R
G
R
P
G
--------
W
H
V
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
I
------
A
-----------------
L
------------
T
-------
R
------------
I
----------------------
G
-----------
T
---
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
-----
G
E
-
R
R
--
F
A
R
H
Y
V
H
T
G
M
I
G
---------------------------------------------------------------------
V
L
V
S
Q
L
R
A
Q
G
V
D
P
S
A
I
R
L
G
L
F
S
-
G
--
H
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
--
N
-------
A
--
R
L
A
R
W
----
R
S
A
T
A
-
L
-
P
-----------------
E
-----------------
A
--------------------
P
D
--------
A
T
D
V
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
D
-
A
--
L
S
Y
G
--
G
H
--
D
T
E
S
-------------
P
--
R
L
V
A
T
T
V
D
A
L
L
G
V
D
L
--------------------------------------------------------------------------------
5
PsiBlast_PDB
75.42
31%
-67
- C3 -
3C8Z
7
MSHC_MYCS2
A:
[42-408]
------------------------
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
E
R
A
E
----
R
-
D
---
G
-------------------------------------------
I
----------------
D
W
------------
R
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
--
Y
V
--
A
A
--
T
--
D
--
A
I
A
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
ED
A
-
E
-
Y
----
P
D
V
Y
F
R
A
D
A
T
A
Q
------------------
F
G
Y
---------------------------------------------
E
S
---
G
-----------
Y
-----------------------------------
D
-----------------------
R
-------
D
-----------------------------
T
M
-----------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
T
--
L
-
F
A
E
---------------------------------------------------------------------
R
------------------------------------------------
G
---------------------------
G
-------------------
D
---------------------
P
----------
D
--
R
-----
P
-----
G
KSDQL----------
D
-
A
------
L
-------
L
--------
W
---------------
R
----------------------------------------------------------------------------
A
E
R
P
G
E
P
S
W
P
S
----
P
F
G
R
G
R
P
G
--------
W
H
V
E
----
C
-----
S
-------------------------------------------------------
A
------------------------------
I
------
A
-----------------
L
------------
T
-------
R
------------
I
----------------------
G
-----------
T
---
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
-----
G
E
-
R
R
--
F
A
R
H
Y
V
H
T
G
M
I
G
---------------------------------------------------------------------
V
L
V
S
Q
L
R
A
Q
G
V
D
P
S
A
I
R
L
G
L
F
S
-
G
--
H
Y
R
E
D
R
F
W
S
N
E
V
L
D
E
A
--
N
-------
A
--
R
L
A
R
W
----
R
S
A
T
A
-
L
-
P
-----------------
E
-----------------
A
--------------------
P
D
--------
A
T
D
V
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
T
D
-
A
--
L
S
Y
G
--
G
H
--
D
T
E
S
-------------
P
--
R
L
V
A
T
T
V
D
A
L
L
G
V
D
L
--------------------------------------------------------------------------------
34
HHSearch
54.69
19%
-51
- C3 -
3KFL
13
?
A:
[31-467]
-------------------------
T
T
P
I
Y
Y
V
N
A
S
P
H
I
G
H
V
Y
S
T
L
I
V
D
V
L
G
R
Y
H
R
V
K
G
E
E
V
F
V
M
T
G
T
D
E
H
---
G
Q
K
V
A
E
A
A
A
----
K
-
Q
---
G
-------------------------------------------
V
----------------
S
P
------------
M
D
F
T
T
S
V
S
S
E
F
K
Q
C
F
Q
E
M
N
Y
D
-
M
N
--
Y
--
F
I
--
R
T
--
T
--
N
P
T
H
E
K
L
V
Q
D
I
W
K
K
L
A
A
K
G
D
I
Y
----
L
-
G
-
K
----
Y
E
G
W
Y
S
V
S
D
E
S
F
L
T
AQNV
A
D
G
V
D
R------
D
G
K
---------------------------------------------
P
C
---
K
-----------
V
-----------------------------------
S
--------------------------------------------------------------
L
-----------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------
S
-
G
H
-
V
V
T
---------------------------------------------------------------------
W
------------------------------------------------
V
E
E
E
N
Y
M
F
RLSAF
R
E
R
L
L
K
---------
Y
-------------------
F
---------------------
H
----------
D
--
H
P
NCIV
P
-----
E
---------------
F
R
R
------
R
-------
E
--------
V
---------------
I
----------
K
T
V
----------------------------------------------------
E
K
---------
G
L
F
D
L
S
I
S
R
K
R
ESVM
N
W
S
I
P
V
P
G
DERHC---
I
Y
V
W
----
L
-----
D
-------------------------------------------------------
A
------------------------------
L
------
F
-----------------
N
------------
Y
-------
Y
------------
T
G
A
L
T
R
V
A
TDG
T
E
T
L
D
EDHHALN
R
-----------
W
---
P
A
D
V
H
V
V
G
K
D
I
L
K
F
H
A
I
Y
W
P
A
F
L
M
S
A
-------
E
-
L
P
--
L
P
E
R
L
V
S
H
G
W
W
T
-
K
-----------------------------------------------
D
-
H
-------
K
K
I
S
K
S
L
G
N
A
F
D
P
V
E
K
A
K
E
-
F
G
I
D
A
L
K
Y
F
L
M
R
E
S
--
N
F
Q
D
D
G
D
Y
S
D
K
N
M
V
A
R
--
L
N
G
-----
E
--
L
A
D
T
L
G
N
L
V
S
R
C
V
A
P
K
-
I
-----------------
N
VNGMW
P
E
P
A
E
YS-----
E
S
D
K
T
L
I
--------------
A
S
--------
L
N
N
L
A
G
T
V
D
H
Y
Y
-
C
L
P
D
I
Q
H
A
L
I
A
I
F
D
V
L
R
--
S
--
L
N
A
Y
--
V
T
--
E
N
A
P
-------------
W
--
K
L
V
K
M
D
T
A
R
L
G
T
V
L
Y
V
T
M
E
G
L
R
I
C
T
M
-----
F
L
Q
-----
P
V
M
P
------
Q
K
A
K
E
I
M
D
A
L
G
V
P
E
A
A
R
V
G
M
E
N
Y
L
F
G
I
V
K
P
G
T
K
I
A
G
L
A
E
G
Q
V
V
---
37
HHSearch
53.34
15%
-63
- C3 -
1FFY
4
SYI1_STAAU
A:
[53-724]
-------------------------
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
---
G
L
P
I
E
Q
A
L
T
----
K
-
K
---
G
-------------------------------------------
V
----------------
D
R
KKMS
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
-
G
D
FN
D
--
P
Y
--
I
T
--
L
K
P
E
--
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
----
K
-
G
-
K
----
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
EAE
I
E
-----------
Y
H
D
K
R
S
A
S
I
Y
V
A
F
N
----------------------------------
V
K
---
D
DKGVVDAD---
A
K
F
I
I
W
T
TTPWTIPSN
V
A
I
T
V
HPELKYGQYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
-------
K
EYTGKELEWV
V
A
Q
H
P
FLDR
E
S
L
V
I
N
G
DHV
T
T
-----------------------------------------------------------------------------
D
----------------------------------------------------------------------------------------------
A
-
G
T
-
G
C
V
---------------------------------------------------------------------
H
T
A
PGHGED----------------------------------------
D
YIVGQQYEL
P
V
I
S
P
I
D
DKGVFTEEGGQ
F
EGMFYDKANKAVTDL----
L
TEKGA
L
L
K
L
D
F
I
T
H
S
Y
P
H
DWR
T
----------
K
--
K
-----
P
-----
V
I
F
R
A
T
P
Q
W
F
A
SIS--
K
-
V
R
Q
D
---
I
L
D
A
I
E
N
T
N
--------
F
KV
N
W
G
----------
K
----------
T
-
R
I
Y
N
M
------------------------------------------------
V
R
---------
D
R
G
E
W
V
I
S
R
Q
R
----
V
W
G
V
P
L
P
V
--------
F
Y
A
E
----
N
-----
G
-------------------------------------------------------
E
I
I
M
T
K
E
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
R
EAKD
L
------
L
PEGFTHPGSPNG
T
F
T
K
E
T
DIM---------
D
-------
V
------------
W
F
D
S
G
S
S
HRGVLETRPEL-----
S
-----------
F
---
P
A
D
M
Y
L
E
G
S
D
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
T
------
R
G
-
V
S
--
P
Y
K
F
L
L
S
H
G
F
V
M
-
D
-----------------------------------------------
G
E
G
-------
K
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
-
K
G
A
D
I
A
R
L
W
V
S
S
-
T
--
D
Y
L
A
D
V
R
I
S
D
E
I
L
K
Q
T
--
S
-------
D
--
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
-
N
-----------------
D
-----------------
F
NPDTDSIPESELL
E
V
D
R
Y
L
L
N
R
--------
L
R
E
F
T
A
S
T
I
N
N
Y
-
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
VE
L
--
S
N
F
Y
--
L
D
--
Y
G
K
D
-------------
I
--
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
-----
K
L
L
-----
A
P
I
L
------
V
H
T
A
E
E
V
W
S
H
T
P
H
V
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
---
33
HHSearch
53.01
16%
-60
- C3 -
2X1L
4
?
A:
[16-439]
------------------------
I
T
T
A
I
A
Y
P
N
G
V
P
H
I
G
H
A
Y
E
Y
I
A
T
D
A
I
A
R
F
K
R
L
D
G
Y
D
V
R
Y
L
T
G
T
D
V
H
---
G
Q
K
M
A
E
T
A
A
----
K
-
E
---
G
-------------------------------------------
I
----------------
P
A
------------
A
E
L
A
R
R
N
S
D
V
F
Q
R
L
Q
E
K
L
N
I
S
-
F
D
--
R
--
F
I
--
R
T
--
S
D
A
D
--
H
Y
E
A
S
K
A
I
W
K
R
M
A
D
A
G
D
I
Y
----
L
-
D
-
A
----
Y
K
G
W
Y
S
I
R
D
E
R
F
------------------
F
T
E
NETTEQPDG
T
R
I
A
T-------------------------------
E
T
---
G
-----------
A
-----------------------------------
P
-----------------------
V
-------
T
-----------------------------
W
T
-----------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------
E
Q
T
Y
-
F
F
R
LSAY
T
D
R
--------------------------------------------------------------
L
L
-----------------------------------------------
A
---------------------------
L
-------------------
Y
---------------------
E
----------
E
--
H
-----
P
-----
E
---------------
F
-
I
GP
D
A
R
R
N
-------
E
--------
I
---------------
V
----------
S
F
V
----------------------------------------------------
S
G
---------
G
L
K
D
L
S
I
S
R
T
T
F---
D
W
G
V
P
V
P
D
--------
H
P
D
H
----
V
MY
V
W
V
D
-------------------------------------------------------
A
------------------------------
L
------
T
-----------------
N
------------
Y
-------
L
T
G
V
GFPDTES
E
S
F
R
R
--------------------
Y
-----------
W
---
P
A
D
L
H
M
I
G
K
D
I
I
R
F
H
T
V
Y
W
P
A
F
L
M
S
A
-------
G
-
L
P
--
L
P
K
R
I
F
A
H
G
W
L
L
-
N
-----------------------------------------------
R
-
G
-------
E
K
M
S
K
S
I
G
N
V
V
D
P
V
N
L
V
D
T
-
F
G
L
D
Q
V
R
Y
F
L
L
R
-
E
V
-
P
F
G
Q
D
G
S
Y
N
E
D
A
I
I
G
R
--
V
-------
N
AD
L
A
N
E
L
G
N
L
A
Q
R
S
L
S
M
V
-
A
-----------------
K
NLGA
A
V
P
D
P
G
E
FT
D
E
D
T
A
L
L
------------------
A
A
--------
A
D
A
L
L
E
R
V
R
E
H
F
-
D
V
P
A
M
H
L
A
L
E
A
I
W
S
V
L
G
--
A
--
A
N
R
Y
--
F
S
--
A
Q
E
P
-------------
W
--
V
L
R
K
S
D
A
A
E
D
Q
Q
R
F
R
T
V
L
Y
T
T
L
E
V
V
R
-----
I
A
S
-----
L
L
L
Q
------
P
V
M
P
E
S
T
A
K
L
L
D
L
L
G
Q
P
T
D
E
R
D
F
S
A
I
A
N
R
I
K
P
G
T
S
L
P
A
P
S
G
I
F
---
39
HHSearch
52.38
17%
-67
- C3 -
2V0C
10
?
A:
[38-761]
-------------------------
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
---
G
L
P
A
E
N
A
A
L
----
K
-
F
---
G
-------------------------------------------
V
----------------
H
P
------------
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
-
Y
D
WD
R
--
E
V
--
T
T
CE
P
--
E
--
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
----
R
-
A
-
K
----
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
NEQVV-----------
E
G
R
CWR------------------------------------------
H
E
---
D
-----------
T
-----------------------------------
P
-----------------------
V
-------
E
K
R
E
L
E
Q
W
Y
L
--------------------
R
I
TAY
A
E
R
L
L
K
D
LEGLNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
-------------------------------------
E
GKE
V
R
I
P
V
F
T
TRPDTLFGAT
F
L
V
L
A
PEHPLTLELAAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
AEGRE
K
T
G
V
F
LG
A
Y
A
L
NPATG
E
R
I
P
I
W
T
A
DYVLFG
Y
-
G
T
-
G
A
I
---------------------------------------------------------------------
M
------------------------------------------------
A
---------------------------
V
-------------------
P
---------------------
A
----------
H
--
D
-----
Q
-----
R
---------------
D
-
Y
------
E
-------
F
--------
A
---------------
R
----------
K
-
F
G
L
P
I
K
K
V
I
E
R
P
GEPLPEPLERAYE
E
P
G
I
M
V
NSGPFDGTE
S
E
E
G
K
R
K
V
I
A
W
L
E
E
K
GL
G
K
G
R
V
T
Y
R
L
R
D
W
L
I
S
R
Q
R
----
Y
W
G
T
P
I
P
M
--------
V
H
C
E
A---
C
-----
G
V
V
P
V
P
EEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY
E
T
T
C
PKCG----------
G
P
A
K
R
DT
D
T
----------------------
M
D
T
F
F
D
S
S
-----------------
W
Y
Y
L
---------
R
-------
Y
------------
T
D
PHNDRLPFD
P
E
K
A
N
A
------
W
-----------
M
---
P
V
D
Q
Y
I
G
G
V
E
H
A
V
L
H
L
L
Y
S
R
F
F
T
K
F
L
H
D
L
GMV
K
V
-
E
E
--
P
F
Q
G
L
F
T
Q
G
M
V
L
-
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
-
G
T
L
H
L
W
K
P
A
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
-
Q
G
A
D
I
A
R
I
T
I
L
F
-
A
A-
P
P
E
N
E
M
V
W
T
E
E
G
V
Q
G
A
--
W
-------
R
--
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
TSGVFQAEAL-------
E
-----------------
G
K
D
R
E
L
Y
--------------
G
K
--------
L
H
E
T
L
K
K
V
T
E
D
L
-
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
N
--
A
--
L
Y
E
Y
--
R
K
--
D
R
P
V
-------------
T
--
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
-----
H
W
F
-----
W
P
D
S
------
L
F
E
A
G
W
P
E
L
D
E
K
A
L
E
-------------------------------
45
HHSearch
50.43
16%
-56
- C3 -
3FNR
5
SYR_CAMJE
A:
[34-452]
------------------------
L
E
Y
V
S
A
N
P
T
G
P
L
H
I
G
H
A
R
G
A
V
F
G
D
T
L
T
R
L
A
R
H
L
G
Y
K
F
N
T
E
Y
Y
V
N
D
A
---
G
N
Q
I
Y
L
L
G
L
----
S
-
I
L
L
S
V
K
E
SILH
E
N
V
E
Y
P
E
Q
Y
Y
K
G
E
Y
I
V
D
L
A
K
E
A
F
E
K
FGKEFFSEEN
I
P
S
----------------
L
A
------------
D
W
A
K
D
K
M
L
V
L
I
K
Q
N
L
E
Q
A
K
I
K
-
I
D
--
S
--
Y
V
--
S
E
--
R
--
S
--
Y
Y
D
A
L
N
A
T
L
E
S
L
K
E
H
K
G
I
Y
----
E
-
Q
-
E
----
G
K
I
W
L
A
S
S
Q
K
G
---------------------
D
---------------------------------------------
E
K
---
D
-----------
R
-----------------------------------
V
-----------------------
I
-------
I
------------------------------
R
-----------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------
D
-
G
R
-
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------
L
---------------------
A
----------
A
------------------------------
D
-
I
------
V
-------
Y
--------
H
---------------
K
----------
D
-
K
----------------------------------------------------
M
--------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------------------
G
-----------
Y
---
G
K
C
I
N
I
W
G
A
D
H
H
G
-
Y
I
P
R
M
K
A
A
M
E
F
L
-------
G
-
F
D
SN
N
L
E
I
I
L
A
Q
M
V
S
L
-
L
K
----------------------------------------------
D
-
G
EP-----
Y
K
M
---
A
G
N
F
I
L
M
S
D
V
V
D
E
-
I
G
S
D
A
L
R
Y
I
F
L
S
-
K
--
K
C
D
T
H
L
E
F
D
I
S
D
L
Q
K
E
--
D
SS-----
N
--
P
V
Y
Y
I
N
Y
A
H
A
R
I
H
Q
V
F
-
A
K
A
GKKIDDVMKADLQSL
N
Q
D
G
V
-------------
N
L
L
------------------
F
E
--------
A
L
N
L
K
A
V
L
N
D
A
F
-
E
A
R
A
L
Q
K
I
P
D
Y
L
K
N
L
A
A
--
N
--
F
H
K
F
--
Y
N
--
E
N
K
V
VGSAN
E
N
D
L
L
K
L
F
S
--
L
V
A
L
S
I
K
T
A
F
S
L
M
G
I
E
A
K
N
K
M
--------------------------------------------------------------------------
36
HHSearch
50.19
18%
-54
- C3 -
2D5B
1
SYM_THET8
A:
[10-421]
---------------------------
P
I
Y
Y
V
N
A
E
P
H
L
G
H
A
Y
T
T
V
V
A
D
F
L
A
R
W
H
R
L
D
G
Y
R
T
F
F
L
T
G
T
D
E
H
---
G
E
T
V
Y
R
A
A
Q
----
A
-
A
---
G
-------------------------------------------
E
----------------
D
P
------------
K
A
F
V
D
R
V
S
G
R
F
K
R
A
W
D
L
L
G
I
A
-
Y
D
--
D
--
F
I
--
R
T
--
T
--
E
E
R
H
K
K
V
V
Q
L
V
L
K
K
V
Y
E
A
G
D
I
Y
----
Y
-
G
-
E
----
Y
E
G
L
Y
C
V
S
C
E
R
F
------------------
Y
T
E
KELVEGLCP------------------------------------
I
H
---
G
-----------
R
-----------------------------------
P
-----------------------
V
-------
E
-----------------------------
R
R
-----------------------------------------------------------------------------
K
----------------------------------------------------------------------------------------------
E
-
G
N
Y
F
F
R
MEKY
R
P
W
L
-------------------------------------------------------------
Q
------------------------------------------------
E
---------------------------
Y
-------------------
I
---------------------
Q
----------
E
--
N
-----
P
DLIRP
E
G
Y
R
------------
N
-
E
------
V
-------
L
--------
A
---------------
M
----------
L
------------------------------------------------------
A
E
---------
P
I
G
D
L
S
I
S
R
P
K
SRV-
P
W
G
I
P
L
P
W
DE------
N
H
V
T
----
F
-----
V
W
F
D
----------------------------------------------------
A
------------------------------
L
------
L
-----------------
N
------------
Y
-------
V
S
A
L
DY-------
P
E---------------------
G
E
A
Y
R
T
F-----
W
---
P
H
A
W
H
L
I
G
K
D
I
L
K
P
H
A
V
F
W
P
T
M
L
K
A
A
-------
G
-
I
P
--
M
Y
R
H
L
N
V
G
G
F
L
L
G
P
-----------------------------------------------
D
-
G
-------
R
K
M
S
K
T
L
G
N
V
V
D
P
F
A
L
L
E
K
-
Y
G
R
D
A
L
R
Y
Y
L
L
R
-
E
I-
P
Y
G
Q
D
T
P
V
S
E
E
A
L
R
T
R
--
Y
E
A
-----
D
--
L
A
D
D
L
G
N
L
V
Q
R
T
R
A
M
L
-
F
-----------------
R
FAEGRIPE---------
P
VAGEEL--------------
A
E
--------
G
T
G
L
A
G
R
L
R
P
L
V
-
R
E
L
K
F
H
V
A
L
E
E
A
M
A
Y
V
K
--
A
--
L
N
R
Y
--
I
N
--
E
K
K
P
-------------
W
--
E
L
F
K
K
E
P
E
E
A
R
A
V
L
Y
R
V
V
E
G
L
R
I
A
S
I
-----
L
L
T
-----
P
A
M
P
------
D
K
M
A
E
L
R
R
A
L
G
L
K
E
E
V
R
L
E
E
A
E
R
W
G
L
A
E
P
R
P
I
P
E
E
A
P
V
L
F
P
K
K
---
40
HHSearch
49.38
15%
-65
- C3 -
1ILE
2
SYI_THET8
A:
[43-721]
-------------------------
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
---
G
L
P
V
E
L
E
V
E
----
K
K
L
---
G
-------------------------------------------
L
KS
K
R
E
I
E
A
Y
G
I
E
R
F
N
Q
A
C
------------
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
-
V
D
--
L
ED
A
Y
AT
L
E
--
P
--
T
--
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
----
R
-
D
-
H
----
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
A
L
G
---------
Y
K
E
---------------------------------------------
I
Q
---
D
P
S
V
Y
V
R
F
P
L
KE
P
KKLGLE
K
A
---------------------------
S
L
L
I
W
T
TT----------------
P
-------
W
-----------------------------
T
L
PGNV
A
A
A
V
H
PE
Y
T
Y
A
A
F
Q
V
GD
E
A
L
I
L
EE
G
L
G
R
K
LLGEGTQV
L
K
T
F
P
GKALEG
L
P
Y
T
P
PYPQALEKGY
F
V
V
L
A
DYVSQ
E
----------------------------------------------------------------------------------------------
D
-
G
T
-
G
I
V
---------------------------------------------------------------------
H
Q
APAFG
A
E
D
L
E
T
A
R
V
Y
G
L
P
L
L
KTVDEEGKLLVEPFKGLY
F
R
E
A
N
R
A
I
L
R
---------------------------
D
L
R
G
R
GLLF
K
E
E
S
Y
L
H
S
Y
P
H
C
---------------------
W
----------
R
--
C
-----
S
-----
T
P
L
M
Y
Y
A
T
E
S
W
F
I
KNT
L
-
F
------
K
D
E
-----
L
I
R
N
N
Q
E
IH
W
---------------
V
PPHIKEG
R
Y
G
E
-
W
----------------------------------------------------
L
K
---------
N
L
V
D
W
A
L
S
R
N
R
----
Y
W
G
T
P
L
P
I
--------
W
V
C
Q
A---
C
-----
G
K
E
E
A
I
GS
F
Q
E
L
K
A
R
ATKPLPEPFDPHR
P
Y
V
D
Q
V
E
L
A
CACG
G
T
M
R
R
V
P
Y
V
I
D
V
W
Y
D
S
------------------------------
G
------
A
-----------------
M
PFASL-------
H
YPFEH
E
E
V
------------
F
R
E
--------------------
S
-----------
F
---
P
A
D
F
I
A
E
G
I
D
Q
T
R
G
W
F
N
S
L
H
Q
L
G
V
M
L
------
F
G
-
S
I
--
A
F
K
N
V
I
C
H
G
L
I
L
-
D
E----------------------------------------------
K
-
G
-------
Q
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
-
F
G
A
D
A
L
R
W
Y
I
Y
V
-
S
A-
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
--
V
-------
R
D
-
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
-
N
-----------------
L
DRPDLKNPPPPEKRP--
E
M
D
R
W
L
L
--------------
A
R
--------
M
Q
D
L
I
Q
R
V
T
E
A
L
-
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
--
E
D
L
S
Q
W
Y
--
V
R
--
R
N
R
R
-------------
R
--
F
W
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
-----
L
A
A
-----
P
F
T
P
------
F
L
A
E
V
L
W
Q
N
L
V
R
S
V
R
L
E
A
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
---
32
HHSearch
48.86
15%
-53
- C3 -
3H99
4
SYM_ECOLI
A:
[22-471]
------------------------
V
T
C
A
S
P
Y
A
N
G
S
I
H
L
G
H
M
L
E
H
I
Q
A
D
V
W
V
R
Y
Q
R
M
R
G
H
E
V
N
F
I
C
A
D
D
A
H
---
G
T
P
I
M
L
K
A
Q
----
Q
-
L
---
G
-------------------------------------------
I
----------------
T
P
------------
E
Q
M
I
G
E
M
S
Q
E
H
Q
T
D
F
A
G
F
N
I
S
-
Y
D
--
N
--
Y
H
--
S
T
--
H
--
S
E
E
N
R
Q
L
S
E
L
I
Y
S
R
L
K
E
N
G
F
I
K
----
N
-
R
-
T
----
I
S
Q
L
Y
D
P
E
K
G
M
F
L
P
DRF
V
K
G
T
CPKCKSPDQ
Y
G
D
---------------------------------------------
N
C
EVC
G
-----------
A
-----------------------------------
T
-----------------------
Y
S
P-----
T
-----------------------------
E
L
IEPKSV-----------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
S
-
G
A
-
T
P
V
---------------------------------------------------------------------
M
------------------------------------------------
R
D
S
E
H
F
F
F
D-------------------
L
PS-----------------
F
---------------------
S
E
M
L
Q
A
W
T
R
SG
A
--
L
-----
Q
-----
E
Q
V
A
N
-----------
K
-
M
------
Q
-------
E
--------
W
---------------
F
-----------------------------------------------------------------
E
S
---------
G
L
Q
Q
W
D
I
S
R
D
A
P---
Y
F
G
F
E
I
P
N
APGKYFYV
W
L
D
A
P
I
G
L
M
-----
G
-------------------------------------------------------
S
------------------------------
F
------
K
-----------------
N
L
C
D
K
R
GDSV
S
F
D
E
-------
Y
------------
W
----------------------
K
-----------
K
DST
A
E
L
Y
H
F
I
G
K
D
I
V
Y
F
L
S
L
F
W
P
A
M
L
E
G
S
-------
N
-
F
R
--
K
P
S
N
L
F
V
H
G
Y
V
T
-
V
-----------------------------------------------
N
-
G
-------
A
K
M
S
K
S
R
G
T
F
I
K
A
S
T
W
L
N
H
-
F
D
A
D
S
L
R
Y
Y
Y
T
A
-
K
LS
S
R
I
D
D
I
D
L
N
L
E
D
F
V
Q
R
V
N
A
-------
D
--
I
V
N
K
V
V
N
L
A
S
R
N
A
G
F
I
-
N
-----------------
K
RFDGVLASE--------
L
AD
P
Q
L
Y
--------------
K
T
--------
F
T
D
A
A
E
V
I
G
E
A
W
-
E
S
R
E
F
G
K
A
V
R
E
I
M
A
L
A
D
--
L
--
A
N
R
Y
--
V
D
--
E
Q
A
P
-------------
W
--
V
V
A
K
Q
E
G
R
D
A
D
L
Q
A
I
C
S
M
G
I
N
L
F
R
V
L
-----
M
T
Y
-----
L
K
P
V
------
L
P
K
L
T
E
R
A
E
A
F
L
N
T
E
L
T
W
D
G
I
Q
Q
P
L
L
G
H
K
V
N
P
F
K
A
L
Y
N
R
I
D
M
R
---
38
HHSearch
48.33
15%
-52
- C3 -
1GAX
3
SYV_THETH
A:
[39-654]
-------------------------
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
---
G
I
A
T
Q
V
V
V
E
R
LLL
K
-
E
---
G
-------------------------------------------
K
----------------
T
R
HDLG
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
-
A
D
--
W
SR
E
A
--
F
T
MD
E
--
K
--
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
----
R
-
A
-
P
----
R
L
V
N
W
C
P
R
C
E
T
T
L
S
DLE
V
E
-----------
T
E
P
T
P
G
K
L
Y
T
L
R
Y
E
V
EG
G
G
F
I
E
I
A
T
VRPETVFADQ
A
I
A
V
HPEDERYRH
L
L
---
G
-----------
K
RARIPLTE
V
--------------------------
W
-----------------------
I
P
I
L
A
D
PA
V
-----------------------------
E
K
-----------------------------------------------------------------------------
D
----------------------------------------------------------------------------------------------
F
-
G
T
-
G
A
L
K
V
T
PAHD
P
L
D
Y
E
I
G
E
R
H
G
L
K
P
V
S
VINLEG
R
M
E
GERVPEALRGLD
R
F
E
A
R
R
K
A
V
E
L
F
REAGHL
V
K
E
E
D
Y
T
I
------------------------------------------------
A
L--------------------------
A
T------------------
C
---------------------
S
----------
R
CG
T
-----
P
-----
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
--
P
-
L
------
A
E
E
-----
V
--------
L
K
G
L
R
R
GDIAFVPERW
K
----------
K
-
V
N
M
D
W
------------------------------------------------
L
E
---------
N
V
K
D
W
N
I
S
R
Q
L
----
W
W
G
H
Q
I
P
A
--------
W
Y
C
E
D---
C
-----
Q
A
V
N
V
P
R
PERYLEDPTSCEACGSPRLKRDE
D
V
F
D
T
W
F
S
------------------
S
------------------------------
A
------
L
-----------------
W
PL----------
S
-------
T
------------
L
----------------------
G
WPEET
E
D
L
K
A
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
F
------
M
G
-
E
R
--
P
F
K
T
V
L
L
H
G
L
V
L
-
D
E----------------------------------------------
K
-
G
-------
Q
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
-
Y
G
A
D
A
L
R
F
A
L
I
Y
-
L
A-
T
G
G
Q
D
I
R
L
D
L
R
W
L
E
M
A
--
R
-------
N
--
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
-
E
-----------------
G
FQAK
E
D
T
P
T
L
A
D
R
----
F
M
R
------------------
S
R
--------
L
S
R
G
V
E
E
I
T
A
L
Y
-
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
SE
F
--
C
D
W
Y
--
L
E
--
A
A
K
P
-------------
A
--
L
K
A
G
N
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
-----
M
P
F
-----
L
T
S
E
------
L
Y
Q
A
L
T
G
K
E
E
L
A
L
E
A
W
P
E
P
G
G
R
D
E
E
A
E
R
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
---