@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0684: (2015-12-03 )
MMNIPNIENCDLHGKAVLLRVDFNIPIKNGKVHDATRVLRSLPTIRHLVNAGAKVIIISHFGRPRAKDNNLSLKNVVKTLSQLLNKEVKFVDDCIGKKVQKVVNAIAIRDVILLENLRFYKEEEQNDANFAKQLASLADVYVNDAFSCSHRAHASISRITEFLPSYAGFCLQDELRYLEKAVSFEAKPITAIVGGAKISTKIKMLIRLAEKVDYLVLGGAIANNFLLFNKVNIGKSFFQNGVDSLLHDVVKIADKNNCKIVIPEDVLIAVNSDYSTCILRKTESVLDNDVILDIGPQTLSTISSIVASSKALLWNGPIGVFEHSAFANGTIEVMKVVSDSTHKGKLTSVIGGGDSLSAINAAGLTDKDFTYVSTGGGAFLSWLSGDKMPGIAALQSMLN
Atome Classification :
(52 SA)
.........10........20........-30........40........50..-.-.....60.....--.--.--.-70.........80........90.....-...100.......--110.......120.------.--------------.--------------.--...---------------130........140.......150.......160..---.-..-.-.170.......180.......190.......200...--....210-........220...-.-.-..-230.......240-----.........250---........260......--.--270..--..-..-.--.--280--.......290........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMNIPNIENCDLHG
K
A
V
L
L
R
V
D
F
N
I
PIKN-GK
V
H
D
A
T
R
V
L
R
S
L
P
T
I
R
H
L
V
NAG
A
-
K
-
V
I
I
I
SHFGRPRA--K--D--N-N-L
S
L
K
N
V
V
K
T
L
S
Q
L
L
N
K
E
V
K
F
V
D
D
C
I
G
-
K
K
V
Q
K
V
V
N
A
I
A
I
R
--
D
V
I
L
L
E
N
L
R
F
Y
K
E
E------E--------------Q--------------N--
D
A
N
---------------
F
-
A
K
Q
L
A
S
L
A
D
V
Y
V
NDAFSCSHRAH
A
S
I
S
R
I
T
E
F
L
P
---
S
-
Y
A
-
G
-
F
C
L
Q
D
E
L
R
Y
L
E
K
A
VSFEAK
P
I
T
A
I
VGGA
K
I
S
T
K
I
K
M
L
--
I
R
L
A
E
K--V
D
Y
L
V
LGGAIAN
N
F
-
L
-
L
-
F
N
-KVNI
G
K
S
F
F
Q
N
-------
G
V
D
S
L
L
H
D
V
V
K
----
I
ADKNN
C
K
I
V
IPE
D
V
L
I
--
A
--VN-SD--Y
S
-
T
C
-
I
--
L
--
R
K
T
--
E
S
VLDN
D
V
I
-
L
DIG
P
Q
T
L
S
T
I
S
S
I
V
ASS
K
A
L
L
WNGPIG
V
F
EHSAFANG
T
I
E
V
M
K
V
VSDSTHKGK
L
T
S
V
IGGGDSLSAINAAGLTDK
D
F
T
Y
V
STG
G
G
A
F
L
S
W
LSGDKMP
G
I
A
A
L
Q
S
MLN
2
PsiBlast_PDB
91.23
41%
-130
- C10 -
1PHP
2
PGK_GEOSE
A:
[1-392]
-
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
K
G
--
K
--
V
V-
E
-
E
-
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
G
-
D
E
V
K
A
A
V
D
R
L
N
E
G
--
D
V
L
L
L
E
N
V
R
F
Y
P
G
E
------
E
--------------
K
--------------
N
--
D
P
E
---------------
L
-
A
K
A
F
A
E
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
P
---
A
-
V
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
--
D
N
L
L
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
-
V
-
K
-
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
----
K
A
K
E
K
G
V
R
F
Y
M
P
V
D
V
V
V
--
A
DR
F
A
-
N
D
--
A
N
-
T
K
-
V
--
V
---
P
I
--
D
A
I
P
A
D
W
S
A
-
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
L
D
---
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
-
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
--
82
HHSearch
90.58
41%
-127
* C10 *
1PHP
2
PGK_GEOSE
A:
[1-394]
-
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
K
G
--
K
--
V
--
V
-
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
G
-
D
E
V
K
A
A
V
D
R
L
N
E
G
--
D
V
L
L
L
E
N
V
R
F
Y
P
G
E
------
E
--------------
K
--------------
N
--
D
P
E
---------------
L
-
A
K
A
F
A
E
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
P
---
A
-
V
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
--
D
N
L
L
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
-
V
-
K
-
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
----
K
A
K
E
K
G
V
R
F
Y
M
P
V
D
V
V
V
--
A
--
D
R
-
F
A
--
N
D
-
A
N
-
T
--
K
V
-
V
P
I
--
D
A
I
P
A
D
W
S
A
-
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
L
---
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
-
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
--
1
PsiBlast_PDB
90.56
43%
-119
- C10 -
1VPE
3
PGKT_THEMA
A:
[4-394]
-----
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
K
G
--
E
--
P
--
S
P
E
-
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
G
-
D
E
V
K
K
A
V
E
E
L
K
E
G
--
E
V
L
L
L
E
N
T
R
F
H
P
G
E
------
T
--------------
K
--------------
N
--
D
P
E
---------------
L
-
A
K
F
W
A
S
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
P
---
S
-
V
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
--
T
N
L
M
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
-
L
-
K
-
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
----
K
A
K
E
K
G
V
E
I
V
L
P
V
D
A
V
I
--
A
QK
I
E
-
P
G
--
V
E
-
K
K
-
V
--
V
--
R
I
D
--
D
G
I
P
E
G
W
M
G
-
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
K
G
A
I
T
-
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
-
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
A
25
PsiBlast_CBE
89.12
38%
-128
- C10 -
4NG4
2
PGK_COXBU
C:
[16-397]
-----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
E
E
--
G
KF
E
--
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
I
N
D
W
L
--
K
G
V
-----
A
V
E
P
G
--
Q
A
I
L
C
E
N
V
R
F
N
K
G
E
------
N
--------------
E
--------------
N
--
N
T
E
---------------
L
-
A
K
R
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
-
C
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
--
E
N
L
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
-
L
-
K
-
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
----
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
--
A
--
D
E
L
S
E
--
D
A
-
K
A
-
T
--
V
--
K
N
I
--
D
A
V
T
S
N
E
S
I
-
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
A
----
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
-
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
A
K
84
HHSearch
88.92
42%
-117
- C10 -
1VPE
3
PGKT_THEMA
A:
[2-397]
---
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
K
G
--
E
--
P
--
S
-
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
G
-
D
E
V
K
K
A
V
E
E
L
K
E
G
--
E
V
L
L
L
E
N
T
R
F
H
P
G
E
------
T
--------------
K
--------------
N
--
D
P
E
---------------
L
-
A
K
F
W
A
S
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
P
---
S
-
V
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
--
T
N
L
M
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
-
L
-
K
-
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
----
K
A
K
E
K
G
V
E
I
V
L
P
V
D
A
V
I
--
A
--
Q
K
-
I
E
--
P
G
-
V
E
-
K
--
K
V
V
R
I
D
--
D
G
I
P
E
G
W
M
G
-
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
-
K
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
-
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
A
26
PsiBlast_CBE
88.82
38%
-126
- C10 -
4NG4
2
PGK_COXBU
B:
[16-397]
-----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
E
E
--
G
KF
E
--
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
I
N
D
W
L
--
K
G
V
-----
A
V
E
P
G
--
Q
A
I
L
C
E
N
V
R
F
N
K
G
E
------
N
--------------
E
--------------
N
--
N
T
E
---------------
L
-
A
K
R
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
-
C
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
--
E
N
L
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
-
L
-
K
-
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
----
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
--
A
--
D
E
L
S
E
--
D
A
-
K
A
-
T
--
V
--
K
N
I
--
D
A
V
T
S
N
E
S
I
-
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
A
----
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
-
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
A
K
13
PsiBlast_PDB
88.77
38%
-125
- C10 -
2P9T
1
PGK2_MOUSE
A:
[8-416]
------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
IP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
--
S
I
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
--
G
K
D
SSG
K
K
I
S
A
D
P
A
K
V
E
A
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
--
K
N
M
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
-
L
-
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
----
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
--
G
--
D
K
-
F
D
--
E
N
-
A
K
-
V
--
G
--
Q
A
T
I-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
N
G
C
V
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
--
17
PsiBlast_PDB
88.31
38%
-124
- C10 -
1VJD
2
PGK1_PIG
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
IP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
S
K
V
K
A
D
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
--
49
PsiBlast_CBE
88.18
37%
-127
- C10 -
2ZGV
1
PGK1_HUMAN
A:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
GN
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
------------
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
55
PsiBlast_CBE
88.13
37%
-126
- C10 -
4O3F
2
PGK1_MOUSE
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
N
A
C
A
N
P
A
A
G
--
T
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
D
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
--------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
--
27
PsiBlast_CBE
88.06
36%
-122
- C10 -
1V6S
3
PGK_THET8
B:
[6-390]
--------
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
G
--
P
--
D
--
P
-
K
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
--
E
V
L
L
L
E
N
V
R
F
E
P
G
E
------
E
--------------
K
--------------
N
--
D
P
E
---------------
L
-
S
A
R
Y
A
R
L
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
--
E
S
L
L
P
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
-
L
-
K
-
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
----
R
A
E
A
L
G
V
R
V
Y
L
P
E
D
V
V
A
--
A
ER
I
E
-
A
G
--
V
E
-
T
R
-
V
--
F
---
P
A
--
R
A
I
P
V
P
Y
M
G
-
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
A
L
E
G
A
F
T
-
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
-
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
---
10
PsiBlast_PDB
87.94
36%
-128
- C10 -
1V6S
3
PGK_THET8
A:
[6-390]
--------
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
K
G
--
P
--
D
--
P
-
K
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
-
P
E
A
R
F
A
P
F
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
--
E
V
L
L
L
E
N
V
R
F
E
P
G
E
------
E
--------------
K
--------------
N
--
D
P
E
---------------
L
-
S
A
R
Y
A
R
L
G
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
P
---
A
-
Y
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
--
E
S
L
L
P
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
-
L
-
K
-
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
----
R
A
E
A
L
G
V
R
V
Y
L
P
E
D
V
V
A
--
A
ER
I
E
-
A
G
--
V
E
-
T
R
-
V
--
F
---
P
A
--
R
A
I
P
V
P
Y
M
G
-
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
A
L
E
G
A
F
T
-
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
-
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
---
38
PsiBlast_CBE
87.92
37%
-123
- C10 -
2XE8
2
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
45
PsiBlast_CBE
87.74
37%
-125
- C10 -
3C3A
3
PGK1_HUMAN
B:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
------
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
------------
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
89
HHSearch
87.56
32%
-123
- C10 -
2CUN
5
PGK_PYRHO
A:
[1-403]
---
M
F
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
S
--
E
--
D
--
Y
---
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
--
E
V
A
I
L
E
N
L
R
F
S
A
E
E
------
V
--------------
K
N
K
P
I
E
E
C
-------
E
--
K
T
F
---------------
L
-
V
K
K
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
P
---
M
-
I
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
--
E
N
V
L
R
R
ER
A
D
L
V
L
T
G
G
L
V
A
N
V
F
-
T
-
L
-
A
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
----
E
F
---
Y
P
Y
I
R
T
P
V
D
F
A
V
--
D
--
Y
K
-
G
E
--
R
V
E
I
D
-
L
--
L
--
S
E
N
--
R
G
L
L
H
Q
Y
Q
I
-
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
S
----
P
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
-
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
9
PsiBlast_PDB
87.37
38%
-124
- C10 -
4NG4
2
PGK_COXBU
A:
[16-397]
-----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
E
E
--
G
KF
E
--
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
-----
P
L
I
N
D
W
L
--
K
G
V
-----
A
V
E
P
G
--
Q
A
I
L
C
E
N
V
R
F
N
K
G
E
------
N
--------------
E
--------------
N
--
N
T
E
---------------
L
-
A
K
R
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
-
C
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
--
E
N
L
L
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
-
L
-
K
-
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
----
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
--
A
--
D
E
L
S
E
--
D
A
-
K
A
-
T
--
V
--
K
N
I
--
D
A
V
T
S
N
E
S
I
-
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
A
----
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
-
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
K
51
PsiBlast_CBE
87.31
37%
-123
- C10 -
1KF0
3
PGK1_PIG
A:
[8-416]
------
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
--
S
--
P
MP
D
-
K
-
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
K
T
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
H
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
--
41
PsiBlast_CBE
87.24
37%
-128
- C10 -
3C3C
1
PGK1_HUMAN
B:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-----
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
-------------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
16
PsiBlast_PDB
87.11
38%
-123
- C10 -
1VJC
1
PGK1_PIG
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
IP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
S
K
V
K
A
D
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
K
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
--
31
PsiBlast_CBE
87.01
37%
-121
- C10 -
2X15
3
PGK1_HUMAN
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK---KAE
P
A
K
I
E
A
------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
83
HHSearch
87.00
37%
-122
- C10 -
3Q3V
5
PGK_CAMJE
A:
[6-399]
--
D
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
K
E
--
I
--
S
--
S
-
K
-
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
G
-
E
D
A
K
T
K
A
M
N
L
K
A
G
--
E
I
L
L
L
E
N
L
R
F
E
K
G
E
------
T
--------------
K
--------------
N
--
D
E
N
---------------
L
-
A
K
E
L
A
S
M
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
EKH
K
-
G
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
--
T
N
L
L
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
-
L
-
K
-
A
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
----
K
G
K
N
L
G
V
K
I
Y
L
P
V
D
V
V
A
--
A
--
P
A
-
C
S
--
Q
D
-
V
P
-
M
--
K
F-
V
P
A
--
Q
E
I
P
N
G
W
M
G
-
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
E
G
----
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
-
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
---
43
PsiBlast_CBE
86.99
37%
-127
- C10 -
3C3B
2
PGK1_HUMAN
B:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-----
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
-------------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
40
PsiBlast_CBE
86.98
37%
-124
- C10 -
2XE6
1
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
14
PsiBlast_PDB
86.93
38%
-122
- C10 -
2PAA
1
PGK2_MOUSE
A:
[8-416]
------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
IP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
--
S
I
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
--
G
K
D
SSG
K
K
I
S
A
D
P
A
K
V
E
A
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
--
K
N
M
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
-
L
-
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
----
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
--
G
--
D
K
-
F
D
--
E
N
-
A
K
-
V
--
G
--
Q
A
T
I-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
N
G
C
V
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
--
48
PsiBlast_CBE
86.80
37%
-128
- C10 -
3C39
1
PGK1_HUMAN
A:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK---KAE
P
A
K
I
E
A
------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
-------------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
86
HHSearch
86.76
38%
-118
- C10 -
2WZB
5
PGK1_HUMAN
A:
[3-415]
-
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
--
V
--
P
M-
P
-
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
KGE
P
A
---------
K
--
I
E
A
---------------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
K
A
G
-
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
-
K
-
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
G
Q
A
--
T
V
A
--
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
36
PsiBlast_CBE
86.75
37%
-121
- C10 -
3ZOZ
5
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G----EP
A
K
I
E
A
--------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
42
PsiBlast_CBE
86.72
37%
-125
- C10 -
3C3C
3
PGK1_HUMAN
A:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
-------------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
46
PsiBlast_CBE
86.53
37%
-125
- C10 -
3C3A
1
PGK1_HUMAN
A:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
GN
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
---------
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
34
PsiBlast_CBE
86.53
37%
-121
- C10 -
2WZB
5
PGK1_HUMAN
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G----E
P
A
K
I
E
A
--------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
32
PsiBlast_CBE
86.50
37%
-121
- C10 -
2X13
3
PGK1_HUMAN
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK---KAE
P
A
K
I
E
A
------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
28
PsiBlast_CBE
86.50
38%
-128
- C10 -
2PAA
1
PGK2_MOUSE
B:
[8-416]
------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
IP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
--
S
I
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
--
G
K
D
SSGKKISADPAKVEA
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
--
K
N
M
L
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
-
L
-
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
----
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
--
G
--
D
K
-
F
D
--
E
N
-
A
K
-
V
--
G
--
Q
A
T
I-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
N
G
C
V
T
-
I
I
G
---------------
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
--
37
PsiBlast_CBE
86.37
37%
-120
- C10 -
2YBE
5
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK---K
V
K
A
E
P
A
K
I
E
A
----
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
33
PsiBlast_CBE
86.24
37%
-121
- C10 -
2WZC
5
PGK1_HUMAN
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G----E
P
A
K
I
E
A
--------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
50
PsiBlast_CBE
86.12
37%
-120
- C10 -
4O33
2
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
T
-
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
35
PsiBlast_CBE
86.09
37%
-121
- C10 -
4AXX
5
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK---AE
P
A
K
I
E
A
-------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
47
PsiBlast_CBE
86.00
37%
-125
- C10 -
3C39
1
PGK1_HUMAN
B:
[12-420]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-------
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
-------------
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
30
PsiBlast_CBE
85.88
37%
-117
- C10 -
2Y3I
5
PGK1_HUMAN
A:
[3-416]
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
GN
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
---
53
PsiBlast_CBE
85.72
37%
-120
- C10 -
2WZD
5
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G----E
P
A
K
I
E
A
--------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
54
PsiBlast_CBE
85.62
37%
-120
- C10 -
2X14
3
PGK1_HUMAN
A:
[8-416]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G----E
P
A
K
I
E
A
--------
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
56
PsiBlast_CBE
85.55
36%
-118
- C10 -
1HDI
3
PGK1_PIG
A:
[5-413]
------
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
--
S
--
P
MP
D
-
K
-
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
D
C
V
G
-
P
A
V
E
K
A
C
A
D
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
A
A
G
E
P
A
K
I
K
A
--
F
-
R
A
S
L
S
A
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
K
-
K
A
-
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
S
----
K
A
A
A
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
Q
-
A
K
-
I
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
--
39
PsiBlast_CBE
85.42
37%
-118
- C10 -
2XE7
2
PGK1_HUMAN
A:
[9-417]
------
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
G
K
D
A
S
G
N
K
V
K
A
E
P
A
K
I
E
A
--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
--
29
PsiBlast_CBE
84.97
37%
-118
- C10 -
2Y3I
5
PGK1_HUMAN
D:
[3-416]
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
D
G
VP
M
--
P
--
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
--
S
V
I
L
L
E
N
L
R
F
H
V
E
E
------
E
--------------
G
--------------
K
GK
D
A
S
GNKVKAEPAKIEA--
F
-
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
---
Q
-
K
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
N
N
M
L
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
-
L
K
V
-
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
----
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
--
A
--
D
K
-
F
D
--
E
N
-
A
K
-
T
--
G
--
Q
A
T
VA
S
G
I
P
A
G
W
M
G
-
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
R
G
C
I
T
-
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
-
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
---
58
PsiBlast_CBE
84.87
33%
-111
- C10 -
2CUN
5
PGK_PYRHO
A:
[3-399]
-----
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
S
--
E
--
D
--
Y
-
T
-
T
T
E
E
H
-
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
--
E
V
A
I
L
E
N
L
R
F
S
A
E
E
V
K
N
K
P
I
E
--------------
E
--------------
C
--
E
K
T
---------------
F
L
V
K
K
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
P
---
M
-
I
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
-
T
-
L
-
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
Y
P
Y
I
R
T
P
V
D
F
A
V
--
D
--
Y
K
-
G
E
--
R
V
-
E
I
D
L
--
L
--
S
E
N
--
R
G
L
L
H
Q
Y
Q
I
-
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
S
P
----
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
--
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
6
PsiBlast_PDB
84.83
40%
-118
- C10 -
1LTK
4
PGK_PLAF7
A:
[22-424]
----------
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
L
I
S
H
C
G
R
P
D
G
L-
R
--
N
--
E
-
K
-
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
L
F
L
N
D
C
V
G
-
K
E
V
E
D
K
I
N
A
A
K
E
N
--
S
V
I
L
L
E
N
L
R
F
H
I
E
E
------
E
--------------
G
--------------
K
G
V
D
A
N
G
N
K
V
K
A
N
K
E
D
V
E
K
--
F
-
Q
N
D
L
T
K
L
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
K
---
A
--
S
-
G
-
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
--
K
N
L
L
D
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
-
K
K
V
-
L
N
-
N
M
K
I
G
T
S
L
F
D
E
-------
A
G
S
K
I
V
G
E
I
M
E
----
K
A
K
A
K
N
V
Q
I
F
L
P
V
D
F
K
I
--
A
--
D
N
-
F
D
NN
A
N
-
T
K
-
F
--
V
--
T
D
E
--
E
G
I
P
D
N
W
M
G
-
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
V
E
V
T
K
K
G
A
I
T
-
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
-
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
---
18
PsiBlast_PDB
84.47
37%
-122
- C10 -
1QPG
2
PGK_YEAST
A:
[7-411]
-----
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
N
G
--
E
--
R
--
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
--
S
V
I
L
L
E
N
L
R
Y
H
I
E
E
------
E
G
S
R
K
V
DGQKVKAS
K
E
--------------
D
--
V
Q
K
---------------
F
-
R
H
E
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
---
Q
-
R
A
A
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
D
N
L
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
-
V
-
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
----
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
--
F
S
-
A
D
--
A
N
-
T
K
-
T
--
V
--
T
D
K
--
E
G
I
P
A
G
W
Q
G
-
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
A
G
N
-
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
-
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
-
90
HHSearch
84.08
38%
-120
- C10 -
1QPG
2
PGK_YEAST
A:
[4-414]
--
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
N
G
--
E
--
R
--
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
--
S
V
I
L
L
E
N
L
R
Y
H
I
E
E
------
E
--------------
G
S
R
K
V
DGQKVKAS
K
E
D
--
V
Q
K
---------------
F
-
R
H
E
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
---
Q
R
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
D
N
L
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
-
K
-
K
-
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
----
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
--
A
--
D
A
-
F
S
--
A
D
-
A
N
-
T
--
K
T
V
T
D
K
--
E
G
I
P
A
G
W
Q
G
-
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
-
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
-
57
PsiBlast_CBE
84.08
33%
-108
- C10 -
2CUN
5
PGK_PYRHO
B:
[3-399]
-----
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
Y
S
--
E
--
D
--
Y
-
T
-
T
T
E
E
H
-
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
--
E
V
A
I
L
E
N
L
R
F
S
A
E
E
VKNKPI
E
--------------
E
--------------
C
--
E
K
T
---------------
F
L
V
K
K
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
P
---
M
-
I
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
EN
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
-
T
-
L
-
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
HAEE
I
L
D
E
F
Y
P
Y
I
R
T
P
V
D
F
A
V
--
D
--
Y
K
-
G
E
--
R
V
-
E
I
D
L
--
L
--
S
E
N
--
R
G
L
L
H
Q
Y
Q
I
-
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
S
P
----
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
--
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
4
PsiBlast_PDB
83.39
37%
-124
- C10 -
4FEY
1
PGK_FRATT
A:
[4-390]
-
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
T
E
--
G
EY
D
--
S
-
Q
-
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
W
L
---------
D
G
V
D
V
K
AG
E
I
V
M
C
E
N
V
R
F
N
S
G
E
------
K
--------------
K
--------------
S
--
T
D
D
---------------
L
-
S
K
K
I
A
S
L
G
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
P
V
--
A
-
C
A
-
G
-
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
--
N
N
L
L
D
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
-
I
-
K
-
A
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
----
K
A
K
A
L
G
V
N
I
P
V
P
V
D
V
R
V
--
A
--
K
E
F
S
E
--
N
A
-
Q
A
-
I
--
I
--
K
K
V
--
S
D
V
V
A
D
E
M
I
-
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
----
K
A
L
S
L
A
I
A
Q
S
H
A
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
-
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
I
92
HHSearch
71.68
40%
-107
- C10 -
1FW8
4
PGK_YEAST
A:
[3-344]
---------------------------------------------------------------------------------
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
--
S
V
I
L
L
E
N
L
R
Y
H
I
E
E
------
E
--------------
G
S
R
K
V
DG
Q
K
V
K
A
S
K
E
D
--
V
Q
K
---------------
F
-
R
H
E
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
---
Q
R
A
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
D
N
L
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
-
K
-
K
-
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
----
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
--
A
--
D
A
-
F
S
--
A
D
-
A
N
-
T
--
K
T
V
T
D
K
--
E
G
I
P
A
G
W
Q
G
-
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
-
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
S
19
PsiBlast_PDB
43.41
37%
-7
- C10 -
3PGK
3
PGK_YEAST
A:
[10-412]
-----
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
R
P
N
G
--
E
--
R
--
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
--
S
V
I
L
L
E
N
L
R
Y
H
I
E
E
------
E
GSRKV
D
G
Q
K
V
K
A
SK
E
--------------
D
--
V
Q
K
---------------
F
-
R
H
E
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
---
Q
-
R
A
A
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
--
D
N
L
L
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
-
V
-
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
E
----
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
--
F
S
-
A
S
--
A
N
-
T
K
-
T
--
V
--
T
D
K
--
E
G
I
P
A
G
W
Q
G
-
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
A
G
N
-
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
-
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
-
93
HHSearch
41.12
34%
-109
- C10 -
1FW8
2
PGK_YEAST
A:
[348-413]
--
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
R
P
N
G
--
E
--
R
--
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------