@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0685: (2015-12-03 )
METDIVVIGAGPVGIFTAFQAGMLDMRCHIIDVLDQAGGQCTALYPEKPIYDIPGYPVITAQKLIEQLMEQASPFEPVYHLSQRVEEIANNDSQSFIVVTSAGTKVKCKAIIIAAGNGIFEPNRPPLSGILEYENKSVFYNVNKISDFQDKIIVIAGGGDSAADWTVELSKVAKKIYVIHRRKEFRCVSETRNKLKLLESSGRIELVVPYQLHKLTGNDGQLSAVIIKNITSKEEKKISADFLLPFFGLSMDLGPIGSWDIQLERSRVVVDQATLRTSRDRIYAIGDVAAYLGKLKLILNGFAESTMACYDIYKVIHNSPVNFQYSTSKVVRGKKSDLL
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20......-..30........40........50......-.-.60........70.....-...80.......--.90.--.......100.......110.......120..-.-....130-.........140.-...-..---..150.......160.......170.......180.......190.......200........210.......220.......230.......240.......250......----.260--...-----..-....270.......280.....-..290.......300.......-310....-...320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MET
D
I
V
V
IGAG
P
V
G
I
F
T
A
F
QAG
M
L
D
M
R
-
C
H
I
I
D
V
L
D
QAGG
Q
C
T
ALYPEKPIYDIPG
Y
P
-
V
-I
T
A
Q
K
L
I
E
Q
L
M
E
QASPF
E
-
P
V
Y
H
L
S
Q
R
V
E
E
I
--ANND--S
Q
S
F
I
V
V
TSAG
T
K
V
K
C
K
A
I
I
I
AAGNGIFEPNR-P-PL
S
G
I
---
L
E
YENK
S
V
F
Y
-
N
V-NKI-SD---FQD
K
I
I
V
I
AGGGDSAAD
W
T
V
E
L
S
K
V
A
K
K
I
Y
V
I
HRR
K
E
F
R
C
V
S
E
T
R
N
K
L
K
L
LESS-G
R
I
E
L
V
V
P
Y
Q
L
H
KLTGNDG
Q
L
S
A
V
I
I
K
NIT
S
K
E
E
KKI
S
A
D
F
L
L
P
F
FGLSMDLGPIGS----
W
D
----
I
Q
L
-----
E
R-
S
R
V
V
V
D
Q
A
TLRTSR
D
R
I
Y
A
I
G
D
-
V
A
A
Y
L
G
K
L
K
L
I
L
N
G
F
A
E
S
T
M
A
C
-
Y
D
I
Y
K
V
I
-HNSPV
N
F
Q
YST
S
K
VVRGKKSDLL
25
HHSearch
90.84
40%
-130
- C1 -
2ZBW
1
FENR_THET8
A:
[5-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
-
P
V
Y
S
L
G
E
R
A
E
T
L
--
E
R
E
G
---
D
L
F
K
V
T
T
S
Q
G
N
A
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
R
-
I
-
G
A
P
G
E
---
R
E
F
E
G
R
G
V
Y
Y
-
A
V
-
K
S
K
-
A
E
---
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
E
A
S
V
K
E
L
M
K
A
H
E
E
-
G
R
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
R
W
A
V
V
F
H
N
-
Q
T
Q
E
E
L
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
----
W
G
----
L
A
L
-----
E
K
-
N
K
I
K
V
D
T
T
-
M
A
T
S
I
P
G
V
Y
A
C
G
D
-
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
-
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
E
K
A
A
P
G
T
-----
23
HHSearch
88.43
38%
-132
- C1 -
3AB1
1
FENR_CHLTE
A:
[14-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
-
P
D
V
V
L
N
E
T
V
T
K
Y
--
T
K
L
D
--
D
G
T
F
E
T
R
T
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
---
G
A
F
E
-
P
R
K
L
P
Q
L
GNI
D
H
L
T
G
S
S
V
Y
Y
-
A
V
-
K
S
V
-
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
A
H
E
V
E
R
A
R
A
N
-
G
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
-
S
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
----
L
E
L
-----
Y
E
-
N
A
L
V
V
D
S
H
-
M
K
T
S
V
D
G
L
Y
A
A
G
D
-
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
-
R
H
S
L
S
Y
I
-
K
P
G
--------------------
2
PsiBlast_PDB
87.29
37%
-128
- C1 -
3AB1
1
FENR_CHLTE
A:
[16-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
-
P
D
V
V
L
N
E
T
V
T
K
Y
--
T
K
L
D
--
D
G
T
F
E
T
R
T
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
-
Q
L
G
N
I
---
D
H
L
T
G
S
S
V
Y
Y
-
A
V
-
K
S
V
-
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
A
H
E
V
E
R
A
R
A
N
-
G
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
-
S
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
----
L
E
L
-----
Y
E
-
N
A
L
V
V
D
-
S
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
-
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
-
P
G
---------------------
21
PsiBlast_CBE
87.26
37%
-123
- C1 -
3AB1
2
FENR_CHLTE
B:
[16-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
-
P
D
V
V
L
N
E
T
V
T
K
Y
--
T
K
L
D
--
D
G
T
F
E
T
R
T
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
-
Q
L
G
N
I
---
D
H
L
T
G
S
S
V
Y
Y
-
A
V
-
K
S
V
-
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
A
H
E
V
E
R
A
R
A
N
-
G
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
-
S
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
----
L
E
L
-----
Y
E
-
N
A
L
V
V
D
-
S
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
-
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
-
P
G
E
K
I
R
N
V
F
S
S
V
K
M
A
K
E
K
K
A
---
24
HHSearch
83.97
35%
-133
- C1 -
3LZW
3
FENR2_BACSU
A:
[7-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
-
Q
T
I
C
L
E
Q
A
V
E
S
V
--
E
K
Q
A
--
D
G
V
F
K
L
V
T
N
-
E
E
T
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
-
L
-
E
L
E
N
A
---
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
-
D
D
L
-
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
E
----
H
S
V
E
N
L
H
A
-
S
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
-
D
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
----
L
D
I
-----
E
K
-
N
S
I
V
V
K
S
T
-
M
E
T
N
I
E
G
F
F
A
A
G
D
-
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
-
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
---------
22
PsiBlast_CBE
82.56
36%
-140
- C1 -
3LZX
3
FENR2_BACSU
B:
[9-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
-
Q
T
I
C
L
E
Q
A
V
E
S
V
--
E
K
Q
A
--
D
G
V
F
K
L
V
T
N
E
E
T
H
Y
-
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
-
L
-
E
L
E
N
A
---
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
-
D
D
L
-
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
E
H
S
V
E
N
L
----
H
A
-
S
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
----
L
D
I
-----
E
K
-
N
S
I
V
V
-
K
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
-
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
-
N
N
A
K
A
Y
M
-
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
--------
1
PsiBlast_PDB
81.78
41%
-125
- C1 -
2ZBW
1
FENR_THET8
A:
[6-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
-
P
V
Y
S
L
G
E
R
A
E
T
L
---
E
R
E
--
G
D
L
F
K
V
T
T
S
Q
G
N
A
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
R
-
I
-
G
A
P
G
E
---
R
E
F
E
G
R
G
V
Y
Y
-
A
V
-
K
S
K
-
A
E
---
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
E
A
S
V
K
E
L
M
K
A
H
E
E
-
G
R
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
R
W
A
V
V
F
H
N
Q
T
-
Q
E
E
L
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
----
W
G
----
L
A
L
-----
E
K
-
N
K
I
K
V
D
-
T
T
M
A
T
S
I
P
G
V
Y
A
C
G
D
-
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
-
N
H
A
A
A
Y
A
-
N
P
A
L
K
V
N
P
G
H
S
S
E
K
A
A
P
G
T
----
3
PsiBlast_PDB
79.93
36%
-135
- C1 -
3LZW
3
FENR2_BACSU
A:
[9-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
-
Q
T
I
C
L
E
Q
A
V
E
S
V
--
E
K
Q
A
--
D
G
V
F
K
L
V
T
N
E
E
T
H
Y
-
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
-
L
-
E
L
E
N
A
---
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
-
D
D
L
-
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
E
H
S
V
E
N
L
----
H
A
-
S
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
----
L
D
I
-----
E
K
-
N
S
I
V
V
-
K
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
-
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
-
N
N
A
K
A
Y
M
-
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
--------
4
PsiBlast_PDB
78.52
36%
-136
- C1 -
3LZX
3
FENR2_BACSU
A:
[9-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
-
Q
T
I
C
L
E
Q
A
V
E
S
V
--
E
K
Q
A
--
D
G
V
F
K
L
V
T
N
E
E
T
H
Y
-
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
-
L
-
E
L
E
N
A
---
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
-
D
D
L
-
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
E
H
S
V
E
N
L
----
H
A
-
S
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
----
L
D
I
-----
E
K
-
N
S
I
V
V
-
K
S
T
M
E
T
N
I
E
G
F
F
A
A
G
D
-
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
-
N
N
A
K
A
Y
M
-
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
--------
32
HHSearch
75.30
24%
-129
- C1 -
3R9U
2
?
A:
[4-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
N
V
V
M
F
E
K
G
M
-
P
G
G
Q
I
T
S
S
S
---
E
I
E
N
Y
P
G
V
A
-
Q
V
M
D
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
-
L
K
H
-
E
M
V
G
V
E
Q
I
--
L
K
N
S
--
D
G
S
F
T
I
K
L
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
---
A
P
K
K
-
A
-
G
F
K
G
E
---
D
E
F
F
G
K
G
V
S
T
-
C
A
-
T
C
D
G
F
F
---
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
P
S
---
T
V
E
K
V
K
K
N
-
E
K
I
E
L
I
T
S
A
S
V
D
E
V
Y
G
D
K
M
G
V
A
G
V
K
V
K
L
-
K
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
Q
DDSK
F
L
----
C
N
M
-----
E
E
G
G
Q
V
S
V
D
L
K
-
M
Q
T
S
V
A
G
L
F
A
A
G
D
-
L
R
K
D
A
--
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
-
L
S
A
M
A
Y
I
-
E
S
L
--------------------
42
HHSearch
69.06
24%
-130
- C1 -
2Q0L
2
TRXB_HELPY
A:
[1-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
N
A
V
L
F
E
K
G
M
-
P
G
G
Q
I
T
G
S
S
E
---
I
E
N
Y
P
G
V
K
-
E
V
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
G
-
L
K
H
-
E
M
T
A
V
Q
R
V
--
S
K
K
D
---
S
H
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
---
S
P
K
R
-
T
-
G
I
K
G
E
---
S
E
Y
W
G
K
G
V
S
T
-
C
A
-
T
C
D
G
F
F
---
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
---
I
T
L
E
H
A
K
N
N
-
D
K
I
E
F
L
T
P
Y
V
V
E
E
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
----
E
D
NSML
C
K
C
-----
D
E
Y
G
S
I
V
V
D
F
S
-
M
K
T
N
V
Q
G
L
F
A
A
G
D
-
I
R
I
F
A
--
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
-
L
S
V
I
S
Y
L
-
E
H
H
--------------------
46
Fugue
66.44
19%
-115
- C1 -
1HYU
4
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
--
E
R
F
G
G
Q
V
L
---
D
T
V
D
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
-
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
--
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
---
A
K
W
R
N
-
M
-
N
V
P
G
E
---
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
-
C
D
G
-
P
L
---
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
---
S
L
-
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-----
A
----
L
E
R
-----
N
R
-
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
-
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
-
L
S
A
F
D
Y
L
-
I
R
T
K
I
A
-----------------
29
HHSearch
63.60
22%
-130
- C1 -
3F8D
3
?
A:
[15-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
T
P
--
G
G
Q
L
T
E
A
G
---
I
V
D
D
Y
L
G
L
I
-
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-
V
P
V
-
L
L
D
I
V
E
K
I
--
E
N
R
-----
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
---
K
R
R
K
-
L
-
G
V
P
G
E
---
Q
E
F
A
G
R
G
I
S
Y
-
C
S
V
A
D
A
-
P
L
---
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
K
-
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
K
-
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
----
I
E
T
-----
D
T
N
G
Y
I
K
V
D
E
W
-
M
R
T
S
V
P
G
V
F
A
A
G
D
-
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
-
T
S
A
Y
R
Y
V
-
T
E
K
--------------------
33
HHSearch
62.83
19%
-113
- C1 -
1HYU
4
AHPF_SALTY
A:
[212-518]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
--
R
F
G
G
Q
V
L
D
T
V
D
I
E
---
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
-
V
D
V
I
D
S
Q
S
A
S
K
L
--
V
P
A
A
TE
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
---
K
W
R
N
-
M
-
N
V
P
G
E
---
D
Q
Y
R
T
K
G
V
T
Y
-
C
P
-
H
C
D
G
P
L
---
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-----
A
----
L
E
R
-----
N
R
M
G
E
I
I
I
D
A
K
-
C
E
T
S
V
K
G
V
F
A
A
G
D
-
C
T
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
-
L
S
A
F
D
Y
L
I
R
T
K
I
A
------------------
17
PsiBlast_PDB
62.77
22%
-124
- C1 -
3F8D
3
?
A:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
--
E
T
P
G
G
Q
L
T
E
---
A
G
I
V
D
D
Y
L
G
L
I
-
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
--
L
L
D
I
V
E
K
I
--
E
N
R
----
E
-
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
K
-
L
-
G
V
P
G
E
---
Q
E
F
A
G
R
G
I
S
Y
C
S
V
-
A
D
A
-
P
L
---
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
---
Q
P
I
Y
V
E
T
V
K
K
K
-
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
-
D
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
----
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
-
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
-
T
S
A
Y
R
Y
V
-
T
E
K
--------------------
7
PsiBlast_PDB
62.77
26%
-120
- C1 -
3ISH
2
TRXB_HELPY
A:
[3-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
G
G
Q
I
T
G
---
S
S
E
I
E
N
Y
P
G
V
K
E
V
-
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
--
G
L
K
H
E
M
T
A
V
Q
R
V
--
S
K
K
D
--
S
H
-
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
---
S
P
K
R
-
T
-
G
I
K
G
E
---
S
E
Y
W
G
K
G
V
---
S
T
-
C
A
T
-
C
D
GFF
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
---
L
E
H
A
K
N
N
-
D
K
I
E
F
L
T
P
Y
V
V
E
E
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
----
E
D
----
N
S
M
L
C
K
C
D
E
Y
-
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
-
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
-
V
I
S
Y
L
E
H
-
H
----------------------
5
PsiBlast_PDB
62.68
26%
-124
- C1 -
2Q0K
3
TRXB_HELPY
A:
[3-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
G
G
Q
I
T
G
---
S
S
E
I
E
N
Y
P
G
V
K
E
V
-
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
--
G
L
K
H
E
M
T
A
V
Q
R
V
--
S
K
K
D
--
S
H
-
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
---
S
P
K
R
-
T
-
G
I
K
G
E
---
S
E
Y
W
G
K
G
V
---
S
T
-
C
A
T
-
C
D
GFF
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
---
L
E
H
A
K
N
N
-
D
K
I
E
F
L
T
P
Y
V
V
E
E
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
----
E
D
----
N
S
M
L
C
K
C
D
E
Y
-
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
-
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
-
V
I
S
Y
L
E
H
------------------------
6
PsiBlast_PDB
61.65
26%
-120
- C1 -
2Q0L
2
TRXB_HELPY
A:
[3-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
V
K
-
N
A
V
L
F
E
K
G
M
P
G
G
Q
I
T
G
---
S
S
E
I
E
N
Y
P
G
V
K
E
V
-
V
S
G
L
D
F
M
Q
P
W
Q
E
Q
C
F
R
F
--
G
L
K
H
E
M
T
A
V
Q
R
V
--
S
K
K
D
--
S
H
-
F
V
I
L
A
E
D
G
K
T
F
E
A
K
S
V
I
I
A
T
G
G
---
S
P
K
R
-
T
-
G
I
K
G
E
---
S
E
Y
W
G
K
G
V
---
S
T
-
C
A
T
-
C
D
GFF
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
V
E
E
A
I
Y
L
A
N
I
C
K
K
V
Y
L
I
H
R
R
D
G
F
R
C
A
P
I
T
---
L
E
H
A
K
N
N
-
D
K
I
E
F
L
T
P
Y
V
V
E
E
I
K
G
D
A
S
G
V
S
S
L
S
I
K
N
T
A
T
N
E
K
R
E
L
V
V
P
G
F
F
I
F
V
G
Y
D
V
N
N
A
V
L
K
Q
----
E
D
----
N
S
M
L
C
K
C
D
E
Y
-
G
S
I
V
V
D
-
F
S
M
K
T
N
V
Q
G
L
F
A
A
G
D
-
I
R
I
F
A
P
K
Q
V
V
C
A
A
S
D
G
A
T
A
A
L
S
-
V
I
S
Y
L
E
H
-
H
----------------------
18
PsiBlast_PDB
61.49
22%
-125
- C1 -
3F8P
4
?
A:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
--
E
T
P
G
G
Q
L
T
E
---
A
G
I
V
D
D
Y
L
G
L
I
-
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
--
L
L
D
I
V
E
K
I
--
E
N
-----
E
-
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
K
-
L
-
G
V
P
G
E
---
Q
E
F
A
G
R
G
I
S
Y
C
S
V
-
C
D
A
-
P
L
---
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
---
Q
P
I
Y
V
E
T
V
K
K
K
-
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
-
D
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
----
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
-
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
-
T
S
A
Y
R
Y
V
-
T
E
K
--------------------
19
PsiBlast_PDB
61.22
22%
-128
- C1 -
3F8R
3
?
A:
[17-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
--
E
T
P
G
G
Q
L
T
E
---
A
G
I
V
D
D
Y
L
G
L
I
-
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
--
L
L
D
I
V
E
K
I
--
E
N
R
----
E
-
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
K
-
L
-
G
V
P
G
E
---
Q
E
F
A
G
R
G
I
S
Y
C
S
V
-
C
D
A
-
P
L
---
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
---
Q
P
I
Y
V
E
T
V
K
K
K
-
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
-
D
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
----
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
-
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
-
T
S
A
Y
R
Y
V
-
T
E
K
--------------------