@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0709: (2015-12-04 )
MKEQKIQAFEWFRALRDRVVESFLLIEGQSPTDPKIEKRKWDRPGGGGGESTIIYGDVFEKVGVNISKVYGKFADSVVNEIPGASESNGEFWASGISLVSHMQSPLVPAAHMNTRLIYTSKQWFGGGMDFTPTYKNEEDYKYIHESIKTTCDKFDAEYYLKFKEQCDNYFFLQHRKEPRGIGGIFYDNLNSGRWENDFEFTKAVGETFLKIYLHIIRQHMRKPWTKEQRETQLIKRGRYVEFNLLYDRGTKFGLMTDGNPDAIMMSMPPLVKWM
Atome Classification :
(20 SA)
---------.........10....-.....20.--...-....30........-------40.....-....50..-..-....60........70.-.......------------80--------------..------.-------------------..------...-90.-----..--....-.100.......110...-----....120-----..-------.......130.......140.......150.......160.......170.......180.-......190.......200.......210.--......220.......230.......240.......250.....-..-260........270..-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MKE
Q
K
I
Q
A
F
E
-
W
F
R
A
-
L
R
D
R
V
V
E
S
--
F
L
L
-IEGQSPTDPKIEKR-------K-WDRPG-GGGGE
S
T
I
-
I
Y
-
G
D
V
F
E
K
VG
V
N
I
S
K
V
Y
G
K
-
F
A
D
S
V
V
N
------------EI--------------PG------A-------------------SE------SNG-
E
F
W
-----
A
S
--
G
I
S
L
-
V
S
H
M
QSPLVPAAHM
N
T
R
-----
L
I
Y
T
S
-------
K
Q
-------WFGGGMDFTPTYKNE
E
D
Y
K
Y
I
H
E
S
I
K
T
T
C
D
KF
D
A
E
Y
Y
L
K
F
K
E
QCD
N
Y
F
F
LQHRKEPRGIG
G
-
I
F
YDNLNSGRWE
N
D
F
E
F
T
K
A
V
G
E
T
F
L
K
I
Y
L
--
H
I
I
R
Q
H
M
RKPW
T
K
E
Q
R
E
T
Q
L
I
KRG
R
Y
V
E
F
N
L
L
YDRGTK
F
G
L
MTD-GN-P-
D
A
I
M
MSMPPLVKWM-------
5
PsiBlast_PDB
93.10
42%
-81
- C4 -
2QT8
1
HEM6_LEIMA
A:
[23-283]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
V
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
M
V
D
-
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
G
L
P
M
S
S
T
E
------------
R
H
--------------
P
D
------
I
-------------------
A
G
------
C
N
---
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
R
E
GKE
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
6
PsiBlast_PDB
92.10
42%
-79
- C4 -
3DWS
2
HEM6_LEIMA
A:
[23-283]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
V
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
M
V
D
-
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
G
L
P
M
S
S
T
E
------------
R
H
--------------
P
D
------
I
-------------------
A
G
------
C
N
---
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
R
E
GKE
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
22
PsiBlast_CBE
91.96
42%
-91
- C4 -
3DWR
4
HEM6_LEIMA
B:
[23-283]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
V
E
D
-------
K
-
W
T
------
G
G
R
T
R
V
-
M
V
D
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
-------------------------------------------------------------------------
C
N
---
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
----------EP
V
W
---
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
3
PsiBlast_PDB
91.77
42%
-87
- C4 -
3DWR
7
HEM6_LEIMA
A:
[23-283]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
V
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
-
M
V
D
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
------------------------------------------------------------------
G
------
C
N
---
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
R
E
GK
E
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
25
HHSearch
90.99
38%
-72
- C4 -
2AEX
1
HEM6_HUMAN
A:
[38-320]
----------
G
D
M
K
T
K
M
E
L
-
L
I
L
E
-
T
Q
A
Q
V
C
Q
A
--
L
A
Q
-
V
D
G
G
----
A
N
F
S
V
D
-------
R
-
W
E
R
K
E
-
G
G
G
G
I
S
C
V
-
L
Q
D
G
C
V
F
E
K
A
G
V
S
I
S
V
V
H
G
N
-
L
S
E
E
A
A
K
------------
Q
M
--------------
R
S
------
R
-------------------
G
K
V
L
K
T
K
D
G
K
L
-
P
F
C
-----
A
M
--
G
V
S
S
-
V
I
H
P
K
N
P
H
A
P
T
I
H
F
N
Y
R
-----
Y
F
E
V
E
E
ADG
N
K
-
Q
W
-------
W
F
G
G
G
C
D
L
T
P
T
Y
L
N
Q
E
D
A
V
H
F
H
R
T
L
K
E
A
C
D
Q
H
G
P
D
L
Y
P
K
F
K
K
W
C
D
D
Y
F
F
I
A
H
R
G
E
R
R
G
I
G
G
-
I
F
F
D
D
L
D
S
P
S
K
E
E
V
F
R
F
V
Q
S
C
A
R
A
V
V
P
S
Y
I
--
P
L
V
K
K
H
C
D
D
S
F
T
P
Q
E
K
L
W
Q
Q
L
R
R
G
R
Y
V
E
F
N
L
L
Y
D
R
G
T
K
F
G
L
F
T
P
G
S
R
-
I
-
E
S
I
L
M
S
L
P
L
T
A
R
W
E
-------
1
PsiBlast_PDB
90.42
42%
-79
- C4 -
3EJO
-
?
A:
[15-275]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
M
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
M
V
N
-
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
G
L
-----------------------------------
D
------
M
-------------------
T
G
------
C
N
---
F
Q
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
R
E
GKE
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
Y
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
T
R
F
K
V
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
I
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
2
PsiBlast_PDB
86.86
46%
-78
- C4 -
3E8J
4
?
A:
[41-280]
------------------------------------------------------------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
-
I
A
N
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
-----------------------------------------------------------------
G
------
C
N
---
Y
Q
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
K
E
G
K
E
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
Y
Y
F
H
H
V
A
Q
E
L
C
R
P
F
G
A
D
V
Y
E
R
F
K
A
W
C
D
E
Y
F
F
I
P
H
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
A
F
M
Q
A
V
G
K
G
F
I
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
M
S
L
P
P
R
A
R
W
G
-------
21
PsiBlast_CBE
86.50
46%
-74
- C4 -
3E8J
3
?
B:
[41-280]
------------------------------------------------------------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
-
I
A
N
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
G----------------------------------------------------------------
G
------
C
N
---
Y
Q
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
---------GKE
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
Y
Y
F
H
H
V
A
Q
E
L
C
R
P
F
G
A
D
V
Y
E
R
F
K
A
W
C
D
E
Y
F
F
I
P
H
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
A
F
M
Q
A
V
G
K
G
F
I
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
M
S
L
P
P
R
A
R
W
G
-------
9
PsiBlast_PDB
86.32
41%
-75
- C4 -
1TLB
-
HEM6_YEAST
A:
[48-300]
--------------------------------------------------------------------
G
G
G
G
T
S
M
V
-
I
Q
D
G
T
T
F
E
K
G
G
V
N
V
S
V
V
Y
G
Q
-
L
S
P
A
A
V
S
------------
A
M
KADHKNLRLPEDPK
T
G
------
L
-------------------
P
V
------
T
D
G
V
K
F
F
-----
A
C
--
G
L
S
M
-
V
I
H
P
V
N
P
H
A
P
T
T
H
L
N
Y
R
-----
Y
F
E
T
W
-------
N
Q
DGTPQ
T
W
W
F
G
G
G
A
D
L
T
P
S
Y
L
Y
E
E
D
G
Q
L
F
H
Q
L
H
K
D
A
L
D
K
H
D
T
A
L
Y
P
R
F
K
K
W
C
D
E
Y
F
Y
I
T
H
R
K
E
T
R
G
I
G
G
-
I
F
F
D
D
Y
D
E
R
D
P
Q
E
I
L
K
M
V
E
D
C
F
D
A
F
L
P
S
Y
L
--
T
I
V
K
R
R
K
D
M
P
Y
T
K
E
E
Q
Q
W
Q
A
I
R
R
G
R
Y
V
E
F
N
L
I
Y
D
R
G
T
Q
F
G
L
R
T
P
-
G
S
R
V
-
E
S
I
L
M
S
L
P
E
H
A
S
W
L
-------
8
PsiBlast_PDB
86.16
41%
-75
- C4 -
1TKL
-
HEM6_YEAST
A:
[50-302]
--------------------------------------------------------------------
G
G
G
G
T
S
M
V
-
I
Q
D
G
T
T
F
E
K
G
G
V
N
V
S
V
V
Y
G
Q
-
L
S
P
A
A
V
S
------------
A
M
KADHKNLRLPEDPK
T
G
------
L
-------------------
P
V
------
T
D
G
V
K
F
F
-----
A
C
--
G
L
S
M
-
V
I
H
P
V
N
P
H
A
P
T
T
H
L
N
Y
R
-----
Y
F
E
T
W
-------
N
Q
DGTPQ
T
W
W
F
G
G
G
A
D
L
T
P
S
Y
L
Y
E
E
D
G
Q
L
F
H
Q
L
H
K
D
A
L
D
K
H
D
T
A
L
Y
P
R
F
K
K
W
C
D
E
Y
F
Y
I
T
H
R
K
E
T
R
G
I
G
G
-
I
F
F
D
D
Y
D
E
R
D
P
Q
E
I
L
K
M
V
E
D
C
F
D
A
F
L
P
S
Y
L
--
T
I
V
K
R
R
K
D
M
P
Y
T
K
E
E
Q
Q
W
Q
A
I
R
R
G
R
Y
V
E
F
N
L
I
Y
D
R
G
T
Q
F
G
L
R
T
P
-
G
S
R
V
-
E
S
I
L
M
S
L
P
E
H
A
S
W
L
-------
23
PsiBlast_CBE
86.00
41%
-78
- C4 -
1TLB
1
HEM6_YEAST
S:
[48-300]
--------------------------------------------------------------------
G
G
G
G
T
S
M
V
-
I
Q
D
G
T
T
F
E
K
G
G
V
N
V
S
V
V
Y
G
Q
-
L
S
P
A
A
V
S
------------
A
M
KADHKNLRLPEDPK
T
G
------
L
-------------------
P
V
------
T
D
G
V
K
F
F
-----
A
C
--
G
L
S
M
-
V
I
H
P
V
N
P
H
A
P
T
T
H
L
N
Y
R
-----
Y
F
E
T
W
-------
N
Q
DGTPQTW
W
F
G
G
G
A
D
L
T
P
S
Y
L
Y
E
E
D
G
Q
L
F
H
Q
L
H
K
D
A
L
D
K
H
D
T
A
L
Y
P
R
F
K
K
W
C
D
E
Y
F
Y
I
T
H
R
K
E
T
R
G
I
G
G
-
I
F
F
D
D
Y
D
E
R
D
P
Q
E
I
L
K
M
V
E
D
C
F
D
A
F
L
P
S
Y
L
--
T
I
V
K
R
R
K
D
M
P
Y
T
K
E
E
Q
Q
W
Q
A
I
R
R
G
R
Y
V
E
F
N
L
I
Y
D
R
G
T
Q
F
G
L
R
T
P
-
G
S
R
V
-
E
S
I
L
M
S
L
P
E
H
A
S
W
L
-------
7
PsiBlast_PDB
85.47
40%
-73
- C4 -
2AEX
1
HEM6_HUMAN
A:
[72-319]
------------------------------------------------------------
R
-
W
E
R
K
E
-
G
G
G
G
I
S
C
V
-
L
Q
D
G
C
V
F
E
K
A
G
V
S
I
S
V
V
H
G
N
-
L
S
E
E
A
A
K
------------
Q
M
--------------
R
S
R
G
K
V
L
K
T
-------------------
K
D
------
G
K
L
-
P
F
C
-----
A
M
--
G
V
S
S
-
V
I
H
P
K
N
P
H
A
P
T
I
H
F
N
Y
R
-----
Y
F
E
V
E
-------
E
A
DG
N
K
Q
W
-
W
F
G
G
G
C
D
L
T
P
T
Y
L
N
Q
E
D
A
V
H
F
H
R
T
L
K
E
A
C
D
Q
H
G
P
D
L
Y
P
K
F
K
K
W
C
D
D
Y
F
F
I
A
H
R
G
E
R
R
G
I
G
G
-
I
F
F
D
D
L
D
S
P
S
K
E
E
V
F
R
F
V
Q
S
C
A
R
A
V
V
P
S
Y
I
--
P
L
V
K
K
H
C
D
D
S
F
T
P
Q
E
K
L
W
Q
Q
L
R
R
G
R
Y
V
E
F
N
L
L
Y
D
R
G
T
K
F
G
L
F
T
P
-
G
S
-
R
I
E
S
I
L
M
S
L
P
L
T
A
R
W
E
-------
24
HHSearch
83.77
40%
-81
- C4 -
1TXN
1
HEM6_YEAST
A:
[10-270]
----------
L
P
I
R
Q
Q
M
E
A
-
L
I
R
R
-
K
Q
A
E
I
T
Q
G
--
L
E
S
-
I
D
T
V
-----
K
F
H
A
D
-------
T
-
W
T
R
G
N
D
G
G
G
G
T
S
M
V
-
I
Q
D
G
T
T
F
E
K
G
G
V
N
V
S
V
V
Y
G
Q
-
L
S
P
A
A
V
S
------------
A
M
--------------
K
A
------
D
-------------------
H
K
NLRLP-
D
G
V
-
K
F
F
-----
A
C
--
G
L
S
M
-
V
I
H
P
V
N
P
H
A
P
T
T
H
L
N
Y
R
-----
Y
F
E
T
W
N
QDGTPQ
T
W
-------
W
F
G
G
G
A
D
L
T
P
S
Y
L
Y
E
E
D
G
Q
L
F
H
Q
L
H
K
D
A
L
D
K
H
D
T
A
L
Y
P
R
F
K
K
W
C
D
E
Y
F
Y
I
T
H
R
K
E
T
R
G
I
G
G
-
I
F
F
D
D
Y
D
E
R
D
P
Q
E
I
L
K
M
V
E
D
C
F
D
A
F
L
P
S
Y
L
--
T
I
V
K
R
R
K
D
M
P
Y
T
K
E
E
Q
Q
W
Q
A
I
R
R
G
R
Y
V
E
F
N
-----------------------------------------
26
HHSearch
80.74
42%
-2
- C4 -
1VJU
-
HEM6_LEIMA
A:
[9-284]
---------
M
S
L
A
V
E
A
V
K
D
-
F
L
L
K
-
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
----
A
T
F
V
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
-
M
V
D
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
-
G
---------------------------------------------------------------
I
------
A
G
C
-
N
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
R
EGKE
P
-
V
W
-------
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
4
PsiBlast_PDB
78.23
42%
5
- C4 -
1VJU
-
HEM6_LEIMA
A:
[23-283]
-------------------------
L
Q
D
D
I
C
E
A
--
L
E
A
-
E
D
G
Q
A
----
T
F
V
E
D
-------
K
-
W
T
R
E
G
-
G
G
G
G
R
T
R
V
M
V
D
-
G
A
V
I
E
K
G
G
V
N
F
S
H
V
Y
G
K
G-------------------------------------------
I
-------------------
A
G
------
C
N
---
F
E
-----
A
M
--
G
V
S
L
-
V
I
H
P
K
N
P
H
V
P
T
S
H
A
N
V
R
-----
L
F
V
A
E
-------
R
E
GKE
P
V
W
-
W
F
G
G
G
F
D
L
T
P
Y
Y
A
V
E
E
D
C
R
D
F
H
Q
V
A
Q
D
L
C
K
P
F
G
A
D
V
Y
A
R
F
K
G
W
C
D
E
Y
F
F
I
P
Y
R
N
E
A
R
G
I
G
G
-
L
F
F
D
D
L
N
E
W
P
F
E
K
C
F
E
F
V
Q
A
V
G
K
G
Y
M
D
A
Y
I
--
P
I
V
N
R
R
K
N
T
P
Y
T
E
Q
Q
V
E
F
Q
E
F
R
R
G
R
Y
A
E
F
N
L
V
I
D
R
G
T
K
F
G
L
Q
S
G
-
G
R
-
T
-
E
S
I
L
I
S
L
P
P
R
A
R
W
G
-------
10
PsiBlast_PDB
76.21
41%
-78
- C4 -
1TXN
1
HEM6_YEAST
A:
[50-270]
--------------------------------------------------------------------
G
G
G
G
T
S
M
V
-
I
Q
D
G
T
T
F
E
K
G
G
V
N
V
S
V
V
Y
G
Q
-
L
S
P
A
A
V
S
A
M
KADHKNLRLP-----------------------------------------------------
D
G
V
K
F
F
-----
A
C
--
G
L
S
M
-
V
I
H
P
V
N
P
H
A
P
T
T
H
L
N
Y
R
-----
Y
F
E
T
W
-------
N
Q
DGTPQ
T
W
W
F
G
G
G
A
D
L
T
P
S
Y
L
Y
E
E
D
G
Q
L
F
H
Q
L
H
K
D
A
L
D
K
H
D
T
A
L
Y
P
R
F
K
K
W
C
D
E
Y
F
Y
I
T
H
R
K
E
T
R
G
I
G
G
-
I
F
F
D
D
Y
D
E
R
D
P
Q
E
I
L
K
M
V
E
D
C
F
D
A
F
L
P
S
Y
L
--
T
I
V
K
R
R
K
D
M
P
Y
T
K
E
E
Q
Q
W
Q
A
I
R
R
G
R
Y
V
E
F
N
-----------------------------------------
42
Fugue
47.31
16%
-16
- C4 -
4RHO
1
?
A:
[4-259]
---DKIHHH
H
H
H
E
N
L
Y
F
Q
G
M
E
I
K
A
M
F
R
D
V
S
L
S
S
RN
F
S
E
M
L
S
R
E
S
K
V
V
A
A
L
A
A
K
SPLMAHA
N
-
W
R
L
K
G
-
N
S
L
E
E
A
T
L
-
Y
---
P
A
F
D
A
D
G
S
P
S
T
P
A
L
A
V
-
L
N
E
E
Q
R
G
------------
K
----------------
K
------
H
-------------------
S
A
------
S
H
A
-
A
I
W
NGNTR
P
N
--
E
G
A
S
M
S
C
H
V
S
D
E
K
V
L
P
D
R
F
S
T
R
-----
L
-----------------------
G
V
P
D
C
Y
A
K
------
S
Q
D
L
A
D
V
V
T
T
I
V
A
A
F
N
P
---
L
V
V
E
A
S
P
E
G
Y
F
D
K
Q
V
F
D
D
K
P
G
V
G
W
M
L
Y
L
P
K
V
I
T
Q
Q
Q
V
P
E
A
R
A
L
I
P
V
S
A
K
G
K
Q
T
G
T
--
I
I
V
S
V
T
-
D
A
P
F
S
V
D
--
N
P
E
H
V
A
I
A
N
R
I
E
I
R
L
V
D
Q
D
--------------------
L
L
P
A
Y
V
D
I
--------
40
Fugue
41.01
13%
-55
- C4 -
4J1V
3
MOB1A_HUMAN
A:
[9-180]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------
R
Q
A
-
V
M
L
-----
P
E
--
G
E
D
L
-
N
E
W
I
A
V
N
T
V
D
F
F
N
Q
I
N
M
-----
L
Y
G
T
I
-------
T
E
-------
F
C
T
E
A
S
C
P
V
M
S
A
G
P
R
Y
E
Y
H
W
-
A
D
P
I
K
C
S
A
P
K
Y
I
D
Y
L
M
T
W
V
Q
D
Q
L
D
D
E
-------------
T
-
L
F
P
S
K
I
G
V
P
F
P
K
N
F
M
S
V
A
K
T
I
L
K
R
L
F
R
V
Y
A
--
H
I
Y
H
Q
H
F
D
S
V
M
Q
L
Q
E
------
E
A
H
L
N
T
S
F
K
H
F
I
F
F
V
Q
E
F
N
L
I
D
R
-
R
E
-
L
-
A
P
L
Q
E
L
I
E
K
L
G
----------
37
Fugue
40.13
8%
-6
- C4 -
1NVM
-
ACDH_PSEUF
B:
[1-312]
MN
Q
K
L
K
V
A
I
I
G
S
G
N
I
G
T
D
L
-
M
I
K
V
-
L
R
N
A
K
Y
L
E
--
M
G
A
-
M
V
G
I
D
A
A
S
D
G
L
A
R
A
-------
Q
R
M
G
V
T
T
-
T
Y
A
G
V
E
G
L
-
I
K
-
L
P
E
F
A
D
I
D
F
V
F
D
A
T
S
A
S
-
A
H
V
Q
N
E
A
------------
L
L
--------------
R
Q
------
A
KPG
I
R
L
I
D
LTPAAI
G
P
Y
C
V
P
V
------
V
N
L
-
E
E
H
-----
L
G
KL
N
V
N
M
-
V
T
C
G
G
Q
A
T
I
P
M
V
A
A
V
S
R
V
AKVH
Y
A
E
I
V
-------
A
S
-------
I
S
S
K
S
A
G
P
G
T
R
A
N
I
D
E
F
T
E
T
T
S
K
A
I
E
V
I
G
G
A
A
K
G
K
A
I
I
I
M
N
P
A
-------
E
P
P
L
I
M
R
D
T
V
Y
-
V
L
S
A
A
A
D
Q
A
A
V
A
A
S
V
A
E
M
V
Q
A
V
Q
A
Y
V
P
G
Y
R
LK
Q
Q
V
Q
F
D
V
I
P
E
S
A
P
L
N
I
P
G
L
G
R
F
S
G
L
K
T
S
V
F
L
E
V
E
G
A
A
H
Y
L
P
A
Y
A
-
G
N
-
L
-
D
I
M
T
S
A
A
L
A
T
A
E
R
M
A
Q
S
M
L
N
A
41
Fugue
39.31
20%
-17
- C4 -
1AG2
-
PRIO_MOUSE
A:
[124-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
G
Y
M
L
G
S
-----
A
M
S
R
P
-------
M
I
-------
H
F
G
N
--
D
W
E
D
R
Y
Y
R
E
N
M
Y
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
S
--
N
Q
N
N
F
V
H
D
C
V
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
-
N
F
T
--------
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
V
T
Q
Y
--
Q
K
E
S
Q
A
Y
Y
---------------------------------------------------------------