@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0710: (2015-12-04 )
MSKRYIDSKKENRVDFILRNHGMSVIIMAVIMFLPPVAISVLYFFDIYDQHTNIEINLLVSTLVTLFIVYNVKHYRYLLNIIEFQNAIFANALNHNTEFCLILHKNEDVVYADARFYERFKDYIDNDVTLGKILEVGDISEKDKKALYQALKNNSSVQVRIVLSKKSRISSFLLLCEPIPDNPQIAINSNKILNLSLAPIARPHGYFVLKATQMNKEQVYEELIEKHNIGTYIANTKGIILSVNKRFLDMFELKKLEKGSSINDFIFQSKYNNVATDNNILFFTVNGVPFKAYMSTAMFCDKHHHSYIYGLITPVESNVIDYQLHPCFANSSIAIAQCDVNGSFIKKNTALIKLAGPDNSSIFTLISDDYHMKIREYFLSNRINNASFDVQLNNNDNMKIYFNKFLHNRMMFILCYFVDNTEHKNLEIKLEHYQKMQAIGQLAGGIAHDFNNILTGIIGFCDLLLLQHSAGDPSFGDIIQIQQNAKRGSNLVKQLLAFSRRQTMQPKIIDVNSTIANLCEMIKRLIGENIKFTTYYGRDLGMVRADQGQLEQVILNLAVNASAAMEKGGELTIRTFNKKIDSLNSTPQGMFSPDKEAIEHGNYVMIEVIDTGCGMVSDTVEKVFDPFFSTKDITSGTGLGLSTVYGIIKQTEGYIYVASEVNCGTKFSIFLPMVYISDENHREKGSEEIEKPVVNEVKDNGIILLIEDEDSVREFITKALKRKGFDVIEASMGSKALEIISKKNQHIDLIITDVIMPEVSGPEIVKEALIHRPDINVIFISGYTEDAFLKNDNINIEDFHFLPKPFTLSELGNKVQSVLHKAKKAV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360..-----.....370.......380......--.390.......400.....---..410......----.420.......430------.......-----.440.......450......----.460.......470-----.--...----.--....-480..--.....490--.........500.----..-------...----.510...---....520....---.----.------.---530.....-------.-.540-----.....--....550.......560-....-.-..------------.------------570.......580.......590......----.600.......610.......------------------------620.......630----.---..----....640.......-650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKRYIDSKKEN
R
V
D
F
I
L
R
NH
G
M
S
V
I
I
M
A
V
I
M
FL
P
P
V
A
I
S
V
L
Y
F
F
DIYDQHT
N
I
E
I
N
L
L
V
S
T
L
V
T
L
F
I
V
YN
V
K
H
Y
R
Y
L
L
N
I
I
E
F
Q
N
A
I
F
A
N
ALNHNT
E
F
C
L
I
L
HKNE
D
V
V
Y
A
D
A
R
F
Y
E
R
F
K
D
Y
IDNDVTL
G
K
I
L
EVGDIS
E
K
D
K
K
A
L
Y
Q
A
L
KNNS
S
V
Q
V
R
I
V
LSKKS
R
I
S
S
F
L
L
L
CEPIPDN
P
Q
I
A
INSN
K
I
L
N
L
SLAPIARP
H
G
Y
F
V
L
K
ATQM
N
K
E
Q
V
Y
E
E
L
I
E
KHNI
G
T
Y
I
ANT
K
G
I
I
L
S
V
N
K
R
F
L
D
M
F
E
L
K
K
LEKGSSI
N
D
F
I
F
QSKYNNVATDN
N
I
L
F
F
T
VNGV
P
F
K
A
Y
M
S
T
A
M
F
C
DKHHH
S
Y
I
Y
G
LITPVES
N
V
I
D
Y
Q
L
H
P
CFANS
S
I
A
I
A
Q
CDVNG
S
F
I
KK
N
T
A
L
I
K
L
AGPDN
S
S
I
F
T
-----
L
ISDD
Y
H
M
K
I
R
E
Y
F
L
SNRINN
A
S
F
--
D
V
Q
LNNND
N
M
K
I
Y
F
N
K
F
LH---N
R
M
M
F
I
L
C
Y
F
V----DNTEHK
N
L
E
I
K
L
E
-------
H
Y
Q
K
M
Q
A
-----
I
G
Q
L
A
G
G
I
A
H
D
F
N
N
I
L
T
G
I
I
----
G
F
C
D
L
L
L
L
QHSA-------G--DPS----F--GD
I
I
-
Q
I
Q
Q
N
--
A
K
R
G
S
N
----
L
V
K
Q
L
L
A
F
S
RRQT----MQ-------
P
K
I
----
I
DV
N
S
T
I
---
A
N
L
C
E
M
I
K
R
L
I---G----E------N---
I
K
F
T
T
Y
YG-------R-DL-------G
M
V
RA--D
Q
G
Q
L
E
Q
V
I
L
N
L
AVN
A
--
S
A
A
M-E-KG------------G------------
E
L
T
I
R
T
F
N
K
K
IDSLNSTPQGMFSP
D
K
E
A
I----EHG
N
Y
V
M
I
E
V
IDTGCG
M
V
S
D
T
------------------------
V
E
K
V
F
D
P
FFSTKD----I---TS----GTGL
G
L
S
T
V
Y
G
I
I
K-QTE
G
Y
I
Y
V
A
S
EVNCG
T
K
F
S
I
F
L
P
M
V
Y
ISDENHREK
G
S
E
E
I
E
K
P
V
V
N
EVKDN
G
I
I
L
L
I
ED
E
D
S
V
R
E
F
I
T
K
A
L
K
RKG
F
D
V
I
E
A
SMG
S
K
A
L
E
I
I
SKKN
Q
H
I
D
L
I
I
T
D
VIMPEVS
G
P
E
I
V
K
E
A
LIHRPD
I
N
V
I
F
ISGYTED
A
F
LKNDNINI
E
D
FHFLPKPF
T
L
S
E
L
G
N
K
V
Q
S
V
L
H
K
A
K
KAV
65
HHSearch
77.20
23%
-74
- C4 -
3A0R
1
?
A:
[9-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
RRLKD
L
P
D
F
E
E
I
G
S
V
A
E
---
S
V
F
E
N
K
E
P
V
F
L
N
F
Y
K
F
G
E
R
Y
F
N
I
R
F
S
P
F
R
N
AKT
Q
L
L
E
G
V
I
I
T
I
D
----
D
V
T
E
L
Y
K
Y
E
E
E
R
K
-------
R
R
E
R
L
S
I
-----
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
----
G
F
I
M
R
M
K
K
H
L
D
D
-------
P
--
E
T
L
----
K
--
K
Y
I
N
-
I
I
T
N
E
--
L
S
R
L
E
T
----
I
V
K
E
I
L
E
Y
S
K
E
R
V
----
L
E
-------
F
T
E
----
F
N
L
N
E
L
I
---
R
E
V
Y
V
L
F
E
E
K
I
---
R
K
---
M
------
N
---
I
D
F
C
F
E
T
D
-------
N
-
E
D
-------
L
R
V
E
A
--
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
--
I
E
A
T
-
G
-
E
N
------------
G
------------
K
I
K
I
T
S
E
--------------------------
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
------------------------
K
E
K
I
F
S
P
F
F
T
T
-------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
P
E
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
70.05
23%
-107
- C- -
2C2A
2
?
A:
[1-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
----
N
V
T
E
S
K
E
L
E
R
L
K
----------
R
I
D
R
M
-----
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
----
A
Y
A
E
T
I
Y
N
S
L
G
E
-------
L
DL
S
T
L
----
K
--
E
F
L
E
-
V
I
I
D
Q
--
S
N
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
I
N
-------
R
E
K
----
V
D
L
C
D
L
V
---
E
S
A
V
N
A
I
K
E
F
A
---
S
S
---
H
------
N
---
V
N
V
L
F
E
S
N
-------
V
P
C
P
-------
V
E
A
Y
I
--
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
------------
A
P
D
K
---------
Y
V
K
V
I
L
----------------------
D
----
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.76
24%
-69
- C4 -
4JAV
6
?
A:
[5-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
-
R
L
K
-------
R
I
D
R
M
K
T
-------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
----
A
Y
A
E
T
I
Y
N
S
L
G
E
-------
L
--
D
L
S
T
L
K
E
F
--
L
E
V
I
-
I
D
Q
S
N
----
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
-------
L
E
-------
R
K
S
----
L
Q
I
N
R
E
K
---
V
D
L
C
D
L
V
E
S
A
V
---
N
----
A
------
I
---
K
E
F
A
S
S
H
N
-------
V
-
N
V
L
F
E
S
NVP
C
P
V
E
A
YI
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
-----------------------------------------------
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
S
----
S
---
L
T
YEVP
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.82
23%
-76
- C4 -
4JAU
1
?
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
-
R
L
K
-------
R
I
D
R
M
K
T
-------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
----
G
Y
A
E
M
I
Y
--
N
S
L
-------
G
--
E
L
D
----
L
--
S
T
L
K
-
E
F
L
E
T
--
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
-------
L
E
-------
R
K
S
----
L
Q
I
N
R
E
K
---
V
D
L
C
D
L
V
E
S
A
V
---
N
----
A
------
I
---
K
E
F
A
S
S
H
N
-------
V
-
N
V
L
F
E
S
NVP
C
P
V
E
A
YI
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
-----------------------------------------------
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
S
----------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
68.52
28%
-77
- C4 -
1I58
3
CHEA_THEMA
A:
[5-188]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
I
S
F
V
F
---
N
R
F
P
R
M
V
R
D
L
A
---
K
K
---
M
------
N
---
K
E
V
N
F
I
M
R
-------
G
E
D
T
-------
E
L
D
R
T
--
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
--
I
D
H
G
-
I
-
E
P
------------
K
E
E
R
I
A
K
GKPP
I
G
T
L
I
L
S
A
----------------------
R
----
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
GLID
E
S
K
A
A
T
LS
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
----
K
V
S
E
V
S
----
G
R
G
V
G
M
D
V
V
K
N
V
V
E
-
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.28
23%
-87
- C4 -
4U7N
-
?
A:
[39-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
----
S
Y
I
E
A
L
S
-
D
G
A
W
-------
K
--
D
P
E
----
V
A
P
G
F
L
K
-
V
T
Q
E
E
--
T
D
R
M
I
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
----
G
T
-------
T
R
V
DMEL
V
N
I
N
E
M
F
---
N
Y
V
L
D
R
F
D
M
I
L
---
K
----
K
------
D
---
D
N
---
Y
Y
T
I
K
R
E
F
T
K
R
-
D
L
--------
W
V
E
I
--
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
--
I
K
Y
S
-
P
-
D
G
------------
G
------------
V
V
T
C
R
----------------------
L
L
----
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
------------------------
L
G
H
V
F
D
R
F
F
R
------------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.84
23%
-86
- C4 -
4U7O
1
?
A:
[37-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
----
S
Y
I
E
A
L
S
-
D
G
A
W
-------
K
--
D
P
E
----
V
A
P
G
F
L
K
-
V
T
Q
E
E
--
T
D
R
M
I
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
----
G
T
-------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
---
N
Y
V
L
D
R
F
D
M
I
L
---
K
----
K
------
D
---
D
N
P
A
K
Y
Y
T
I
K
R
E
F
T
K
R
-
D
L
--------
W
V
E
I
--
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
--
I
K
Y
S
-
P
-
D
G
------------
G
------------
V
V
T
C
R
----------------------
L
L
----
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
------------------------
L
G
H
V
F
D
R
F
F
R
V
D
K
----------QG--
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.65
24%
-101
- C- -
2C2A
2
?
A:
[5-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
-
R
L
K
-------
R
I
D
R
M
K
T
-------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
----
A
Y
A
E
T
I
Y
N
S
L
G
E
-------
L
--
D
L
S
TL
K
E
F
--
L
E
V
I
-
I
D
Q
S
N
----
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
-------
L
E
-------
R
K
S
----
L
Q
I
N
R
E
K
---
V
D
L
C
D
L
V
E
S
A
V
---
N
----
A
------
I
---
K
E
F
A
S
S
H
N
-------
V
-
N
V
L
F
E
S
NVP
C
P
V
E
A
YI
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
-----------------------------------------------
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.39
24%
-66
- C4 -
3DGE
3
?
A:
[14-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
R
I
D
R
M
K
T
-------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
----
A
Y
A
E
T
I
Y
N
S
L
G
E
-------
L
--
D
L
S
T
L
K
E
F
--
L
E
V
I
-
I
D
Q
S
N
----
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
-------
L
E
-------
R
K
S
----
L
Q
I
N
R
E
K
---
V
D
L
C
D
L
V
E
S
A
V
---
N
----
A
------
I
---
K
E
F
A
S
S
H
N
-------
V
-
N
V
L
F
E
S
NVP
C
P
V
E
A
YI
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
-----------------------------------------------
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
S
----
S
---
L
T
YEVP
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
65.45
18%
-85
- C4 -
1ID0
2
A:
[2-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
----
H
P
V
A
P
L
L
---
D
N
L
T
S
A
L
N
K
V
Y
Q
--
R
----
K
------
G
---
V
N
I
S
L
D
I
S
-------
P
-
E
--------
I
S
F
V
G
--
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
--
C
K
Y
C
-
L
-
E
F
------------
V
--------------
E
I
S
A
R
--------------------------
Q
T
D
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
------------------------
R
E
V
I
F
D
R
G
Q
R
V
D
T
----
L
---
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
-
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
65.10
25%
-82
- C4 -
1B3Q
-
CHEA_THEMA
A:
[43-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
L
S
H
L
S
R
----
I
T
L
D
L
Q
N
V
V
M
--------
K
-------
I
R
M
----
V
P
I
S
F
V
F
---
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
----
K
------
E
---
V
N
F
I
M
R
G
--------
E
-
D
T
-------
E
L
D
R
T
--
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
--
I
D
H
G
-
I
-
E
P
K
E
E
R
I
A
K
GKPP
I
G
------------
T
L
I
L
S
A
R
--------------------------
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
KGLIDE
S
K
A
A
T
LS
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
-------------------
G
V
G
M
D
V
V
K
N
V
V
E
-
S
L
N
G
S
M
G
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
C
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
---------------------
72
HHSearch
65.03
29%
-88
* C4 *
3A0Y
-
?
A:
[606-752]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
E
----
F
N
L
N
E
L
I
---
R
E
V
Y
V
L
F
E
E
K
I
R
--
K
----
M
------
N
---
I
D
F
C
F
E
T
D
-------
N
-
E
D
-------
L
R
V
E
A
--
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
--
I
E
A
T
-
G
-
E
N
------------
G
------------
K
I
K
I
T
S
E
--------------------------
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
------------------------
K
E
K
I
F
S
P
F
F
T
T
K
---------------
G
T
G
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.42
26%
-50
- C4 -
4GCZ
8
FIXL_BRADU (first)
A:
[117-373]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
F
V
G
I
Q
N
D
I
T
E
H
Q
Q
T
Q
A
R
L
Q
E
L
Q
S
E
L
V
H
V
S
R
L
S
A
-----
M
G
E
M
A
S
A
L
A
H
E
L
N
Q
P
L
A
A
I
S
N
Y
M
K
G
S
R
R
L
L
A
G
S
S
D
P
-------
N
--
T
P
K
----
V
--
E
S
A
L
D
R
A
A
E
Q
--
A
L
R
A
G
Q
----
I
I
R
R
L
R
D
F
V
A
R
G
E
----
S
E
-------
K
R
V
----
E
S
L
S
K
L
I
E
E
A
G
A
L
G
L
A
G
A
R
E
Q
---
N
----
V
------
Q
---
L
R
F
S
L
D
P
G
-------
A
-
D
L
---------
V
L
A
--
D
R
V
Q
I
Q
Q
V
L
V
N
L
F
R
N
A
L
E
A
M
A
Q
-
S
-
Q
R
------------
R
------------
E
L
V
V
----------
T
N
T
P
A
A
---------------
D
D
M
I
E
V
E
V
S
D
T
G
S
G
F
Q
D
D
V
------------------------
I
P
N
L
F
Q
T
F
F
T
T
K
D
---------
T
----
G
M
G
V
G
L
S
I
S
R
S
I
I
E
-
A
H
G
G
R
M
W
A
E
S
N
A
S
G
G
A
T
F
R
F
T
L
P
A
---
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.71
28%
-87
- C4 -
1R62
-
NTRB_ECOLI
A:
[195-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
S
I
---
H
K
V
A
E
R
V
V
T
L
V
---
S
MELP
D
------
N
---
V
R
L
I
R
D
Y
D
-------
P
-
S
L
-------
P
E
L
A
H
--
D
P
D
Q
I
E
Q
V
L
L
N
I
V
R
N
A
--
L
Q
A
L
G
P
-
E
G
------------
G
------------
E
I
I
L
R
T
------------
R
T
A
F
Q
L
T
L
H
G
E
----
R
Y
R
L
A
A
R
I
D
V
E
D
N
G
P
G
I
---------------------------------------------------------
G
L
G
L
S
I
A
R
N
L
I
D
-
Q
H
S
G
K
I
E
F
T
S
W
P
G
-
H
T
E
F
S
V
Y
L
P
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.70
23%
-69
- C4 -
4JAS
2
?
A:
[13-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-------
R
I
D
R
M
K
T
-------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
----
G
Y
A
E
M
I
Y
--
N
S
L
-------
G
--
E
L
D
----
L
--
S
T
L
K
-
E
F
L
E
T
--
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
-------
L
E
-------
R
K
S
----
L
Q
I
N
R
E
K
---
V
D
L
C
D
L
V
E
S
A
V
---
N
----
A
------
I
---
K
E
F
A
S
S
H
N
-------
V
-
N
V
L
F
E
S
NVP
C
P
V
E
A
YI
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
--
V
K
Y
S
-
K
-
K
D
-----------------------------------------------
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
------------------------
K
D
R
I
F
E
Q
F
Y
R
V
D
S
----
S
---
L
T
Y
EVP
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
97
Fugue
63.69
19%
-87
- C4 -
1ID0
2
A:
[1-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
----
H
P
V
A
P
L
L
---
D
N
L
T
S
A
L
N
K
V
Y
---
Q
----
R
K-----
G
---
V
N
I
S
L
D
I
S
-------
P
-
E
I
--------
S
F
V
G
--
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
--
C
K
Y
C
-
L
-
E
F
------------
V
------------
E
I
S
A
R
Q
T
D
E
H
----------------------------
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
------------------------
R
E
V
I
F
D
R
G
Q
R
V
D
T
----
L
---
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
-
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------
96
Fugue
63.21
14%
-47
- C3 -
1JM6
2
PDK2_RAT
A:
[11-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
A
G
A
P
K
Y
I
E
H
F
-
S
K
F
S
P
S
P
L
S
M
K
Q
F
L
D
F
G
A
C
E
K
T
S
F
T
-----
F
L
R
Q
E
L
P
V
R
L
A
N
I
M
K
E
I
N
----
L
L
--
P
D
R
V
L
S
T
P
S
V
Q
L
V
Q
S
W
Y
V
Q
---
S
L
L
D
I
M
E
F
L
D
K
----
D
P
E
D
H
R
T
L
S
Q
F
T
D
-------
A
L
V
T
I
R
N
R
H
N
D
V
V
P
T
M
A
Q
G
V
L
E
Y
D
P
V
S
N
Q
N
I
Q
----
Y
F
L
D
R
F
Y
L
S
R
I
S
-------
I
--
R
M
L
----
I
--
N
Q
H
T
-
L
I
F
D
P
--
K
H
I
G
S
------------
I
D
P
N
C
S
----
V
S
-------
D
V
V
----
K
D
A
Y
D
M
A
---
K
L
L
C
D
K
Y
Y
M
A
S
P
D
-
L
----
E
------
I
---
Q
E
V
N
A
T
N
A
-------
T
-
Q
P
-------
I
H
M
V
Y
--
V
P
S
H
L
Y
H
M
L
F
E
L
F
K
N
A
--
M
R
A
T
-
V
-
E
S
------------
H
------------
E
S
S
L
T
L
P
P
I
K
I
M
V
A
L
G
E
E
-------------------
D
L
S
I
K
M
S
D
R
G
G
G
V
P
L
R
K
------------------------
I
E
R
L
F
S
Y
M
Y
S
T
A
P
----
T
---
P
A
----
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
-
Y
F
Q
G
D
L
Q
L
F
S
M
E
G
F
G
T
D
A
V
I
Y
L
K
A
L
S
T
D
S
V
E
R
L
P
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
62.92
26%
-81
- C4 -
3SL2
2
A:
[3-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
---
S
L
I
I
D
R
F
E
M
T
K
---
E
----
Q
-----------
E
F
I
R
N
L
P
-------
D
-
R
D
-------
L
Y
V
E
I
--
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
--
L
K
Y
S
-
P
-
E
G
------------
G
------------
H
V
T
F
S
I
D
V
--------------------
N
----
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
------------------------
V
E
K
V
F
D
R
F
Y
R
V
D
---------
L
G
----
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
62.90
28%
-79
- C4 -
1R62
-
NTRB_ECOLI
A:
[197-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
I
H
K
V
A
---
E
R
V
V
T
L
V
S
M
E
L
---
P
----
D
------
N
---
V
R
L
I
R
D
Y
D
-------
P
-
S
L
-------
P
E
L
A
H
--
D
P
D
Q
I
E
Q
V
L
L
N
I
V
R
N
A
--
L
Q
A
L
-
G
P
E
G
------------
G
------------
E
I
I
L
R
T
R
T
A
F
Q
------------
L
T
L
H
G
E
----
R
Y
R
L
A
A
R
I
D
V
E
D
N
G
P
G
I
---------------------------------------------------------
G
L
G
L
S
I
A
R
N
L
I
D
-
Q
H
S
G
K
I
E
F
T
S
W
P
G
-
H
T
E
F
S
V
Y
L
P
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
62.46
17%
-72
- C4 -
2E0A
2
PDK4_HUMAN
A:
[92-354]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
K
A
-----
L
S
D
F
V
D
T
L
I
K
V
R
N
R
H
H
N
V
V
P
----
T
M
A
Q
G
I
I
E
Y
K
D
A
C
T
V
D
PVT
N
--
Q
N
L
----
Q
--
Y
F
L
D
-
R
F
Y
M
N
R
I
S
T
R
M
L
-----
M
N
Q
H
I
L
I
F
S
D
S
Q
T
----
G
N
PSHIGSI
D
P
N
----
C
D
V
V
A
V
V
---
Q
D
A
F
E
C
S
R
M
L
C
---
D
----
Q
Y
YL
S
S
P
E
L
K
L
T
Q
V
N
G
K
F
P
-------
D
-
Q
P
-------
I
H
I
V
Y
--
V
P
S
H
L
H
H
M
L
F
E
L
F
K
N
A
--
M
R
A
T
-
V
-
E
H
------------
Q
E
NQP
S
L
T
-----
P
I
E
V
I
V
V
--------------------------
L
G
K
E
D
L
T
I
K
I
S
D
R
G
G
G
V
P
L
R
I
------------------------
I
D
R
L
F
S
Y
T
Y
S
T
A
P
TPNA
P
---
L
A
----
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
-
Y
F
Q
G
D
L
N
L
Y
S
L
S
G
Y
G
T
D
A
I
I
Y
L
K
A
L
S
S
E
S
I
E
K
L
P
V
F
N
K
S
A
F
K
H
Y
-------------------------------------------------------------------------------------------------------------------------------------