@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0725: (2015-12-04 )
MQKKTFTIIDGYGFLFGAYYVLHHLTTTTGMPIGAVYGFLNMVLKYITHSDYLTIALDSGKKNFRHDLYPEYKANRVTPPEGLIPQFTILREAIEAFNLSYEEIEGYEADDIIATLTAKYANHQDLKVVIISSDKDLFQLLNYDVLIFDPIKNIYIDEKQVIEKFGVNSNKLLDLFSLTGDVSDNIPGVPGIGPKTAAKLLDRFNSLNNTIENINNIKQTRTRNILTEHKEKALISRKLLSLCEKVDLQHDVIKYKVLSPNMEKLLSFLKKYEFNSLIGKVEKLFSYNESSTKERTEYSSEALEKFLECCRYEGKVAIHCHFENNVLSKISLSYNEDNIFYIDQNRSQDALITINSALFSNGILKIIHDTRETRKTIPTIEKVLGSVDDLMIMSYSLDTGKHDHSIPNIIAHNLSENVETFSAKTLIAIHEKLKQRLFKEKLFTIYERFDKPLMKVIFNMEKNGILLNIHKLQELSDKFQQLIAVLENDIYNLAGEKFNIASPKQLSDVLFNKMGLNKKKKLKSGSYSTNSVVLEELEIEGVEIASKILDWRHLSKLKSTYTDALIKQVDPLDGRIHTNFSTTVTATGRLSSSSPNLQNIPIRSKEGNLIRQTFIAPKGYKIISADYSQIELRLLAHVANVTAFKEAFANGKDIHGITAGQVFGVQKDMEVDEQLRRKAKSINFGIMYGISQFGLAKRLGITIEEAAEYINYYFSCYPEIKVYMEKVVSTARQHGYVETLFGRRCFVKDINNTIPYLRQFAERAAINAPLQGTAADIIKCAMIQLFDQLKAGKIILQVHDELLVEVENEKVQETAKLMKDVMENIVKISIPLEVEVKISDNWGTTTQTL
Atome Classification :
(90 SA)
.........10........20........30........40.......-.-50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..-----.....330.......340..----...----------..350.......360........370.......380.........390.......400.......410.....------------------------..420---.......430......-----.-440........450.......460.......470.......480.......490.......500.......510......-.520-..-.....530.......540.......550.......560......--.570..--.....580.......590.......600.......-------610......-.-620.......630.......640-.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790--.-----------------------.----.----......800....-...810.......820.....-..830.......840.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
K
K
T
F
T
I
IDG
Y
G
F
L
F
G
A
Y
Y
V
L
H
H
LTTTTGM
P
I
G
A
V
Y
G
F
L
N
M
V
L
K
Y
IT-H-S
D
Y
L
T
I
A
LDSGKKNFRHDLYPEYKANRVTPPEGLI
P
Q
F
T
I
L
R
E
A
I
E
A
FNL
S
Y
E
E
IEGYE
A
D
D
I
I
A
T
L
T
A
K
YANHQ
D
L
K
V
V
I
ISS
D
K
D
L
F
Q
L
LNY
D
V
L
I
F
DPIKNIYI
D
E
K
Q
V
I
E
K
FGVNSN
K
L
L
D
L
FSLTGDVSDNIPGVPGI
G
P
K
T
A
A
K
L
L
D
R
F
N
S
L
N
N
T
I
E
N
I
N
N
I
K
Q
T
R
T
R
N
I
L
T
E
H
K
E
K
A
L
I
S
R
K
L
L
S
L
C
E
K
VDLQHD
V
I
K
Y
K
VLSP
N
M
E
K
L
L
S
F
L
K
KY
E
F
N
S
L
I
G
K
V
E
K
L
FSYNESS
T
K
E
R
TEY
S
S
E
A
L
E
K
F
L
E
C
CRYEG
K
V
A
I
H
C
HFEN-----N
V
L
S
K
I
S
L
S
YNED
N
I
F
Y
I
DQ----NRS----------Q
D
A
L
I
T
I
N
S
A
L
FS-N
G
I
L
K
I
I
HD
T
R
E
T
R
KT
I
P
T
I
--
E
K
V
LGSVD
D
L
M
I
M
S
Y
SLDTGKHDHS
I
P
N
I
I
A
H
N
L
SE
N
------------------------
V
E
T
FS---A
K
T
L
I
A
I
H
E
K
L
K
Q
R
L
F
-----
K
-
E
K
-
L
F
T
I
Y
E
R
F
D
K
P
L
M
K
V
I
F
NMEKN
G
I
L
L
N
I
H
K
L
Q
E
L
S
D
K
F
Q
Q
L
I
A
V
L
EN
D
I
Y
N
LAGEKFNIA
S
P
K
Q
L
S
D
V
L
F
N
K
MGL
N
K
-
K
K
KL-KS-GSYSTN
S
V
V
L
E
E
LEIE
G
V
E
I
A
S
K
I
L
D
W
R
H
L
S
K
L
K
S
T
Y
T
D
A
L
I
K
Q--VDPLD
G
--
R
I
HTNF
S
T
T
V
T
A
TGRLSSSSPNLQNIPIRSKEG
N
L
-------
I
R
Q
T
FIAPK-
G
-
Y
K
I
I
SAD
Y
S
Q
I
E
L
R
L
L
A
H
V
A
N
V
T
-
A
F
K
E
A
FANGKDIHGITAG
Q
V
FGVQK
D
M
E
V
D
E
Q
L
R
R
K
A
KSIN
F
G
I
M
Y
G
I
S
Q
FG
L
A
K
RLGI
T
I
E
E
A
A
E
Y
I
N
Y
Y
F
S
C
Y
P
E
I
K
V
Y
M
E
K
V
V
S
T
A
R
QHG
Y
V
E
T
L
FG
R
R
C
F
V
K
D
IN
N
T
I
P
Y
L
R
Q
F
A
E
R
AAINAPLQ
G
T
A
A
D
I
I
K
C
A
M
I
Q
L
F
D
Q
LK----A-----------------------
G
----
K
----
I
I
L
Q
V
H
D
E
L
L
V
E
V-E
N
E
K
V
Q
E
T
A
K
L
M
K
D
V
M
E
N
I
V
K
-
I
S
I
P
L
E
V
E
V
K
I
SDNWGTTTQTL-
1
PsiBlast_PDB
87.19
36%
-80
- C3 -
1BGX
-
DPO1_THEAQ
T:
[11-827]
--
K
G
R
V
L
L
V
D
G
H
H
L
A
Y
R
T
F
H
A
L
K
G
L
T
T
S
R
G
E
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
K
-
E
D
G
D
A
V
I
V
V
F
D
A
K
A
P
S
F
R
H
E
A
Y
G
G
Y
K
A
G
R
A
P
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
A
R
L
E
V
P
G
Y
E
A
D
D
V
L
A
S
L
-
A
K
K
A
E
K
E
G
Y
E
V
R
I
L
T
A
D
K
D
L
Y
Q
L
L
S
D
R
I
H
V
L
H
P
-
E
G
Y
L
I
T
P
A
W
L
W
E
K
Y
G
L
R
P
D
Q
W
A
D
Y
R
A
L
T
G
D
E
S
D
N
L
P
G
V
K
G
I
G
E
K
T
A
R
K
L
L
E
E
W
G
S
L
E
A
L
L
K
N
L
D
R
L
K
P
A
I
R
E
K
I
L
A
-
H
M
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
A
K
R
R
--
E
P
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
E
----
F
G
L
L
E
S
P
-------------
K
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
--------
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
GGRV
H
R
A
----------
P
E
P
Y
K
A
L
R
D
L
K
E
A
-
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
-------
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
GRLEG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
EM--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-----
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
102
HHSearch
85.11
37%
-72
- C3 -
1BGX
-
DPO1_THEAQ
T:
[10-832]
-
P
K
G
R
V
L
L
V
D
G
H
H
L
A
Y
R
T
F
H
A
L
K
G
L
T
T
S
R
G
E
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
K
E
D
-
G
D
A
V
I
V
V
F
D
A
K
A
P
S
F
R
H
E
A
Y
G
G
Y
K
A
G
R
A
P
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
A
R
L
E
V
P
G
Y
E
A
D
D
V
L
A
S
L
A
K
K
A
-
E
K
E
G
Y
E
V
R
I
L
T
A
D
K
D
L
Y
Q
L
L
S
D
R
I
H
V
L
H
P
E
-
G
Y
L
I
T
P
A
W
L
W
E
K
Y
G
L
R
P
D
Q
W
A
D
Y
R
A
L
T
G
D
E
S
D
N
L
P
G
V
K
G
I
G
E
K
T
A
R
K
L
L
E
E
W
G
S
L
E
A
L
L
K
N
L
D
R
L
K
P
A
-
I
R
E
K
I
L
A
H
M
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
--
A
K
R
R
E
P
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
E
F
G
L
L
E
S
P
K
A
L
E
--------
E
A
P
---
W
P
P
--
P
E
G
A
F
V
G
F
V
L
S
R
K
E
PMW--
A
D
L
L
A
L
A
A
A
R
G
-
G
R
V
H
R
A
P
E
----
P
-------------------
Y
K
-
A
L
--
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
EG
L
G
L
-
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
--
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
-------------------------
T
E
E
A
GER
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
-----
G
E
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
-
I
G
K
T
E
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
-
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
----
E
MG---------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-----
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
103
HHSearch
80.91
40%
-86
- C4 -
2KFN
6
DPO1_ECOLI
A:
[13-605]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
LDNIS
A
N
L
V
G
L
S
F
A
I
E
P
G
V
A
A
Y
I
P
V
----
A
H
D
YLDAPDQIS
R
E
R
A
L
E
L
L
K
P
-
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
K
Y
D
R
G
I
L
A
N
Y
G-
I
E
L
R
G
I
A
F
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
TITFEEI
A
G
K
G
KNQLTFNQIA
L
E
E
A
G
R
Y
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-----
K
H
K
G
-
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
-
L
K
K
T
-
P
-----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
-------
I
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
-
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
EQP
R
-----------------------
V
----
R
----
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
27
PsiBlast_CBE
77.67
43%
-99
- C4 -
4DFK
12
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
124
Fugue
77.51
31%
-74
- C4 -
4X0Q
7
DPOLQ_HUMAN
A:
[6-772]
----
S
L
S
I
I
D
----------------------
V
A
S
D
Q
N
L
F
Q
T
F
I
K
E
W
R
-
C
-
K
K
R
F
S
I
S
L
----------------
A
C
E
K
I
R
D
D
T
L
V
V
G
L
A
V
C
W
G
G
R
D
A
Y
Y
F
S
L
L
D
----------
P
S
L
T
L
K
D
R
M
W
Y
L
Q
S
C
L
R
K
E
S
D
K
E
C
------
S
V
V
I
Y
D
F
I
Q
S
Y
----
K
I
L
L
L
S
C
G
I
---------
S
L
E
Q
S
Y
E
D
---------
P
K
V
A
C
W
L
L
D
P
D
S
Q
----------------------------------------------------
E
P
T
L
H
S
I
V
T
S
F
L
P
H
E
---------------------------------------------------------------------------------------------------------------------------
L
P
L
L
--
E
G
M
E
T
S
Q
G
---
I
Q
S
L
G
L
N
A
G
S
-
E
H
S
---------
G
R
Y
------------------------
R
A
S
V
E
---
S
I
L
I
F
N
S
M
N
Q
L
N
S
L
L
Q
-----
K
-
E
N
-
L
Q
D
V
F
R
K
V
E
M
P
S
Q
Y
C
L
A
L
L
E
L
N
G
I
G
F
S
T
A
E
C
E
S
Q
K
H
I
M
Q
A
K
L
D
A
I
E
T
Q
A
Y
Q
L
A
G
H
S
F
S
F
T
S
S
D
D
I
A
E
V
L
F
L
E
L
K
L
P
P
-
Q
---------
F
S
T
S
K
D
V
L
N
K
L
K
A
L
H
-
P
L
P
G
L
I
L
E
W
R
R
I
T
N
A
I
T
K
V
V
F
P
L
Q
R
E
KC
L
N
P
F
L
G
M
E
R
I
Y
P
V
-
S
Q
S
H
T
A
T
G
R
I
T
F
T
E
P
N
I
Q
N
V
P
-
R
D
F
E
I
K
M
G
M
P
F
S
I
S
M
R
H
A
F
V
P
F
P
-
G
-
G
S
I
L
A
A
D
Y
S
Q
L
E
L
R
I
L
A
H
L
S
H
D
R
-
R
L
I
Q
V
L
N
T
G
A
D
V
F
R
S
I
A
A
E
-
W
K
M
I
E
P
E
S
V
G
D
D
L
R
Q
Q
A
K
Q
I
C
Y
G
I
I
Y
G
M
G
A
K
S
L
G
E
Q
M
G
I
K
E
N
D
A
A
C
Y
I
D
S
F
K
S
R
Y
T
G
I
N
Q
F
M
T
E
T
V
K
N
C
K
R
D
G
F
V
Q
T
I
L
G
R
R
R
Y
L
P
G
I
K
D
N
N
P
Y
R
K
A
H
A
E
R
Q
A
I
N
T
I
V
Q
G
S
A
A
D
I
V
K
I
A
T
V
N
I
Q
K
Q
L
E
----
T
F
H
STFKS
H
G
H
R
E
G
M
L
Q
S
DC
P
I
R
G
G
----
F
----
F
I
L
Q
L
H
D
E
L
L
Y
E
V
-
A
E
E
D
V
V
Q
V
A
Q
I
V
K
N
E
M
E
S
A
V
K
-
L
S
V
K
L
K
V
K
V
K
I
G
A
S
W
G
E
L
K
D
F
D
V
29
PsiBlast_CBE
77.37
43%
-98
- C4 -
4DF8
12
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
21
PsiBlast_CBE
77.36
43%
-99
- C4 -
4ELV
11
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
25
PsiBlast_CBE
77.34
43%
-98
- C4 -
4DFP
15
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
28
PsiBlast_CBE
77.33
43%
-97
- C4 -
4DFJ
18
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
23
PsiBlast_CBE
77.04
43%
-99
- C4 -
4ELT
17
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
26
PsiBlast_CBE
76.98
43%
-96
- C4 -
4DFM
10
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
17
PsiBlast_PDB
76.92
43%
-98
- C4 -
3M8S
12
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
22
PsiBlast_CBE
76.78
43%
-99
- C4 -
4ELU
18
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
31
PsiBlast_CBE
76.74
43%
-98
- C4 -
3RTV
14
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
5
PsiBlast_PDB
76.73
43%
-94
- C4 -
4XIU
3
DPO1_THEAQ
A:
[78-534]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
GRLEG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
15
PsiBlast_PDB
76.69
43%
-96
- C4 -
3LWM
15
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
3
PsiBlast_PDB
76.60
43%
-95
- C4 -
4N5S
12
DPO1_THEAQ
A:
[92-548]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
32
PsiBlast_CBE
76.57
43%
-98
- C4 -
3RRH
9
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
10
PsiBlast_PDB
76.51
43%
-102
- C4 -
1KTQ
-
DPO1_THEAQ
A:
[371-827]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I-----------
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
30
PsiBlast_CBE
76.50
43%
-96
- C4 -
4DF4
6
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
34
PsiBlast_CBE
76.39
42%
-96
- C4 -
3PY8
9
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
16
PsiBlast_PDB
76.36
43%
-97
- C4 -
3M8R
10
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
4
PsiBlast_PDB
76.29
43%
-96
- C4 -
1QTM
5
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
33
PsiBlast_CBE
76.24
42%
-95
- C4 -
4BWM
9
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
M
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
R
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
F
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
93
PsiBlast_CBE
76.21
45%
-107
- C4 -
4DSK
5
?
A:
[180-575]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
------
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
36
PsiBlast_CBE
76.18
42%
-95
- C4 -
3PO4
7
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
88
PsiBlast_CBE
76.16
45%
-105
- C4 -
4BDP
5
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
24
PsiBlast_CBE
76.11
43%
-96
- C4 -
4DLG
10
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
54
PsiBlast_CBE
76.07
45%
-100
- C4 -
4B9T
5
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
7
PsiBlast_PDB
76.06
43%
-98
- C4 -
1QSY
5
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
6
PsiBlast_PDB
76.04
43%
-92
- C4 -
1QSS
5
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
18
PsiBlast_PDB
76.00
43%
-97
- C4 -
3RR7
5
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
-------------------
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
67
PsiBlast_CBE
75.91
45%
-108
- C4 -
2HHX
7
DPO1_BACCA
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
-------
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
94
PsiBlast_CBE
75.74
45%
-102
- C4 -
4DSJ
2
?
B:
[180-575]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
------
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
9
PsiBlast_PDB
75.73
43%
-99
- C4 -
5KTQ
1
DPO1_THEAQ
A:
[82-538]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I-----------
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
100
PsiBlast_CBE
75.70
45%
-104
- C4 -
1U48
6
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
57
PsiBlast_CBE
75.64
45%
-98
- C4 -
4B9M
7
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
89
PsiBlast_CBE
75.63
45%
-102
- C4 -
3BDP
4
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
53
PsiBlast_CBE
75.61
45%
-99
- C4 -
4B9U
7
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
70
PsiBlast_CBE
75.59
45%
-106
- C4 -
2HHT
9
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQ
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
14
PsiBlast_PDB
75.59
43%
-95
- C4 -
3LWL
18
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
-----
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
11
PsiBlast_PDB
75.59
43%
-98
- C4 -
2KTQ
4
DPO1_THEAQ
A:
[77-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
-----------
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
20
PsiBlast_PDB
75.50
43%
-95
- C4 -
3RRG
7
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
-----
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
12
PsiBlast_PDB
75.50
43%
-93
- C4 -
3KTQ
5
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
90
PsiBlast_CBE
75.47
45%
-105
- C4 -
2BDP
5
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
98
PsiBlast_CBE
75.35
45%
-105
- C4 -
1U4B
6
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
68
PsiBlast_CBE
75.33
45%
-104
- C4 -
2HHV
9
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
91
PsiBlast_CBE
75.18
45%
-105
- C4 -
4O0I
5
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQ
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
8
PsiBlast_PDB
75.16
43%
-94
- C4 -
4KTQ
2
DPO1_THEAQ
A:
[78-534]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
LEG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
56
PsiBlast_CBE
75.11
45%
-98
- C4 -
4B9N
8
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
19
PsiBlast_PDB
75.05
43%
-97
- C4 -
3RR8
6
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
-------
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
59
PsiBlast_CBE
75.01
45%
-101
- C4 -
2XY5
6
?
A:
[182-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
61
PsiBlast_CBE
74.99
45%
-102
- C4 -
4UQG
6
?
A:
[180-575]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
86
PsiBlast_CBE
74.90
45%
-101
- C4 -
3PX0
5
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
66
PsiBlast_CBE
74.87
45%
-104
- C4 -
2HW3
8
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQ
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
75
PsiBlast_CBE
74.86
45%
-103
- C4 -
4F3O
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
58
PsiBlast_CBE
74.84
45%
-100
- C4 -
4B9L
7
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
72
PsiBlast_CBE
74.74
45%
-102
- C4 -
2HHQ
8
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
2
PsiBlast_PDB
74.74
43%
-98
- C4 -
4N56
4
DPO1_THEAQ
A:
[92-548]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
EG
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
-------------------
A
K
T
I
N
F
G
V
L
Y
G
---------------------------
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
71
PsiBlast_CBE
74.73
45%
-101
- C4 -
2HHS
7
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
101
PsiBlast_CBE
74.72
45%
-100
- C4 -
1U47
6
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
85
PsiBlast_CBE
74.72
45%
-100
- C4 -
3PX4
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
78
PsiBlast_CBE
74.71
45%
-102
- C4 -
4EZ9
3
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
99
PsiBlast_CBE
74.68
45%
-102
- C4 -
1U49
6
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQ
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
69
PsiBlast_CBE
74.57
45%
-103
- C4 -
2HHU
9
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
95
PsiBlast_CBE
74.52
45%
-102
- C4 -
4DSJ
4
?
A:
[180-575]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
80
PsiBlast_CBE
74.52
45%
-102
- C4 -
4DSF
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
35
PsiBlast_CBE
74.50
42%
-93
- C4 -
3PO5
6
DPO1_THEAQ
A:
[79-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
M
L
L
A
Y
L
L
D
P
---
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
------------------------
W
-
T
E
E
---
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
-
K
T
-
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
-----------
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
--
G
-----------------------
A
----
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
-
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
---
76
PsiBlast_CBE
74.46
45%
-99
- C4 -
4F2S
5
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
60
PsiBlast_CBE
74.41
45%
-100
- C4 -
2XO7
6
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
96
PsiBlast_CBE
74.39
45%
-102
- C4 -
1UA1
5
DPO1_GEOSE
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
55
PsiBlast_CBE
74.39
45%
-98
- C4 -
4B9S
8
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
64
PsiBlast_CBE
74.38
45%
-103
- C4 -
4DQP
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
81
PsiBlast_CBE
74.37
45%
-103
- C4 -
4DSE
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
52
PsiBlast_CBE
74.34
45%
-98
- C4 -
4B9V
8
?
A:
[220-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
S
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
RL
Q
-----------------------
A
----
R
----
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
77
PsiBlast_CBE
74.29
45%
-101
- C4 -
4F2R
5
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
82
PsiBlast_CBE
74.24
45%
-98
- C4 -
3TI0
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
87
PsiBlast_CBE
74.13
45%
-100
- C4 -
3PV8
5
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
74
PsiBlast_CBE
74.07
45%
-100
- C4 -
4F4K
6
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
84
PsiBlast_CBE
74.02
45%
-101
- C4 -
3PX6
5
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
79
PsiBlast_CBE
73.93
45%
-101
- C4 -
4EZ6
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
122
Fugue
73.90
37%
-79
- C4 -
3KTQ
5
DPO1_THEAQ
A:
[1-539]
----
A
L
E
E
A
P
--------------
W
P
P
P
----
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
-
A
--
D
L
L
A
L
A
A
A
R
G
-
G
-
R
V
H
R
A
P
------------
E
P
Y
K
A
L
R
D
L
K
------------------------------------------
E
A
R
G
L
L
A
K
-
D
L
S
V
L
A
L
R
E
-------
G
L
G
L
P
---
P
G
D
D
P
M
L
L
A
Y
L
L
D
----------
P
S
--
N
T
T
P
E
G
V
A
R
R
Y
G
--
G
E
W
--------------------------------------------------------------
T
E
----------------------------------------------------------------------------------------------------------------------------------------------
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
------------------------------------------------------
E
-
E
R
-
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
-
I
G
K
T
-
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
-------
I
R
R
A
F
I
A
E
-E
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
-
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
-
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
----
E
-----------------------
M
G
A
--
R
----
M
L
L
Q
V
H
D
E
L
V
L
E
A
P-
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
-P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
83
PsiBlast_CBE
73.87
45%
-99
- C4 -
3THV
6
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
65
PsiBlast_CBE
73.87
45%
-100
- C4 -
4DQI
4
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
92
PsiBlast_CBE
73.81
45%
-104
- C4 -
4DSL
3
?
A:
[180-575]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQ
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
73
PsiBlast_CBE
73.30
45%
-105
- C4 -
4F8R
2
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
---------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
97
PsiBlast_CBE
73.22
45%
-102
- C4 -
1UA0
5
?
A:
[181-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
-
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
62
PsiBlast_CBE
73.08
45%
-101
- C4 -
4DS5
3
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
---------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
63
PsiBlast_CBE
72.99
45%
-103
- C4 -
4DS4
3
?
D:
[193-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
-
L
K
K
T
-
K
T
-
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
-------
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
---------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
----
E
-----------------------
E
----
R
LQAH
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
48
PsiBlast_CBE
68.93
46%
-87
- C4 -
1KFD
1
DPO1_ECOLI
A:
[179-601]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
-----
K
-
H
K
G
P
L
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
------------------------------------------------
D
-
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
V
R
N
E
E
G
R
R
-------
I
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
-
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
----
A
-----------------------
E
QPR
V
R
----
M
I
M
Q
V
H
D
E
L
V
F
E
V
-
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----