@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0745: (2015-12-04 )
MARTVNVLLPLPIDQLFSYAVKENTDVSVGDYVVVPFGKKRLIGIVWKYSNKNDQELKFIEQKINLPNIRLKLIAFAEWVAQYNVISIGMLAKVIMGGVLKVNHLDKLVHVEQEQEVSEINYQLNPEQQIASNKIISNLNEYSVTLLDGETGSGKTEVYLSVIAQLIKNYSSTPATPNAARTLSFQCPDTQLYKHCNLGPPVGYHPSTLILGSSFPRNLIKNVHFNVRAATPIPSLQTKFLDSSVSYLHDIFMFKAKPTIIFNTLSSPSAGMTPKYVETASNKGSIQVLILLPEIVLTSQLVNRIRSQTSRNLAEWHSGLTLKTRRNNWLNTANGNAQIIIGARSALFLPYKNLKLIIVDEEHDSSFKQEQGTIYNARDMAIILAKIENIPIILSSATPLLETIYHVKNGNYNYVKLAKRFGGAELPLIKVVDTRNNKQWISNELFEGIKQTIEKKQQVMLFLNRRGYAQLAVCKKCGYKIPCSNCAVWLVYHKKKNALLCHHCSYQLKLPEKCSNCQSKQSLFLYGIGIERLLEETVKLIPNAKTAIISSDQKSVSNVIDLVLKEELNIIIGTQIIAKGHNFPKLTLVGVINADLSLENADLRAAEKTYQLLHQVAGRSGRFNEKGMVIVQTNHPESSVIKALQHQKRDSFYEIELESRYKAKMPPFSRLIALIICGKNQIATQKAANEIASFLHNQCLSKKLPSSSSLSFQCLTLKSRKKEFEILGPSPAAISFLNNKYRYRVLLKIYNKHSLSVQKKLKYWIKNCNLSPNIIVTIDVDPISFF
Atome Classification :
(20 SA)
.........10........20........30........40........50...---.....60.....-...70........80........90........100.......110.......120.......130.......140.........150.......160...-....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280--.......290.......300.......310---.-.......320----.......330--.......340--------......--------.--------350----------.........360.......370---------........380---------.--..-----....390.......400.......--.--410.--..--...-...420.--.---..--...--430...---....--..440.......450.---......460.......470.......480.......490.......500.......510.......520.......530.......-540-.......550..--.....560.......570...----....580...-....590....-...600.......610.......620..--.----....630.......640...----....650.......660.......670.......680.......690.......700.......710.......720.......730.......740.....----..750.......760.......770....---...780....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
R
T
V
N
V
L
LPL
P
I
D
Q
L
F
S
Y
A
VKENTDVSVG
D
Y
V
V
VPFGK
K
R
L
I
G
I
V
W
K
YSNKN
D
---
Q
E
L
K
F
I
E
Q
KINL-PN
I
R
L
K
L
I
A
F
A
E
W
V
A
QYN
V
I
S
I
G
M
L
A
K
V
I
MGG
V
L
K
V
N
H
L
D
K
L
V
H
V
E
Q
E
Q
E
V
S
E
I
N
Y
QLN
P
E
Q
Q
I
AS
N
K
I
I
SNLN--
E
Y
S
V
T
L
L
DGETGSG
K
T
E
V
Y
L
S
V
I
A
Q
-
L
I
K
NYSSTPATPNA
A
R
T
L
S
F
QCP
D
T
Q
L
Y
K
HCNLGPPVGYHP
S
T
L
I
LGSSF
P
R
N
L
I
KN
V
H
F
N
V
R
AATPI
P
S
L
Q
T
K
F
L
D
S
S
V
S
Y
L
H
D
I
F
MFKAK
P
T
I
I
F
N
TLSSPSAGMT
P
K
Y
V
ETASN--KG
S
I
Q
V
L
I
LL
P
E
I
V
L
T
S
Q
L
V
N
R
I
R
S
Q
TS
R
----
N
-
L
A
E
W
HSG
L
T
L
----
K
TRRNN
W
L
NT--ANG
N
A
Q
I
I
I
G--------AR
S
A
L
F
--------
L
--------P------------YK
N
L
K
L
I
I
V
DEEHDSSF
K
Q
E-Q---------G
T
I
YNAR
D
M
A
I
---------
I
--
L
A
-----KIENI
P
I
I
LSSA
T
P
L
L
-
E
T
I
Y
HVK--N--G--N--
Y
N
--
Y
V
K
-
L
A
K
R
FGG--A---EL--
P
L
I
--
K
--
V
V
D---TRNN--
K
Q
W
I
S
N
E
L
F
E
G
I
K
Q
T
I
---
E
K
K
Q
Q
V
M
L
F
LNRRG
Y
A
Q
L
A
V
C
K
KCGYKIPCSN
C
A
V
W
L
V
Y
HKKK
N
A
L
L
C
HHC
S
Y
QLKL
P
E
K
C
SNCQSK
Q
S
L
F
L
Y
GI
G
I
E
R
L
L
E
E
T
V
K
-LIP-NA
K
T
A
I
ISS
D
Q
K
--
S
V
S
N
V
I
D
L
V
L
K
EEL
N
I
I
I
G
T
Q
----
I
I
AKGHNF
P
K
-
L
T
L
V
G
V
I
NADL-SLENA
D
L
R
A
A
E
K
T
Y
Q
L
L
H
Q
VAGRSGRFN--E----K
G
M
V
I
V
QTNHP
E
S
S
V
I
K
A
L
Q
----
H
QKRDS
F
Y
E
I
E
LESRYKAKMP
P
F
S
R
L
I
A
L
I
I
CGKNQI
A
T
Q
K
A
A
N
E
I
A
S
F
L
H
N
Q
C
L
S
KKLPSSSS
L
S
F
Q
C
L
TLKSRK
K
E
F
E
I
LGPS
P
A
A
I
S
F
LNNK
Y
R
Y
R
V
L
L
----
K
I
Y
N
KHS
L
S
V
Q
K
K
L
K
Y
W
I
K
NCNLSP
N
I
I
V
---
T
I
DVDPISFF
61
Fugue
94.14
32%
-85
- C2 -
4NL4
3
?
H:
[18-747]
--
S
V
A
H
V
A
L
P
V
P
L
P
R
T
F
D
Y
L
L
P
E
G
M
A
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
E
R
I
G
I
V
A
A
V
S
E
R
S
E
LPL
D
E
L
K
P
V
A
E
A
L
D
D
E
P
V
F
S
T
T
V
W
R
L
L
M
W
A
A
E
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
V
M
L
R
---------------------
Q
G
K
P
A
S
A
T
P
L
W
Y
W
F
A
T
-
E
--
Q
G
Q
V
V
D
L
N
G
L
K
R
S
R
K
Q
Q
Q
A
L
A
A
L
R
Q
G
K
I
W
R
H
Q
V
G
E
L
E
F
N
E
A
A
L
Q
A
L
R
G
K
G
L
A
E
L
A
C
E
A
T
D
W
R
S
A
Y
S
V
A
G
------------
E
R
L
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
A
A
D
R
F
S
A
W
L
L
A
G
I
----------------
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
VL
A
Q
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
A
----
P
-
V
E
V
L
H
S
G
L
N
D
----
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
--------
T
R
S
S
L
F
--------
T
--------
P
------------
F
K
D
L
G
V
I
V
I
D
E
E
H
D
S
S
Y
K
Q
Q
-
E
---------
G
W
R
Y
H
A
R
D
L
A
V
---------
W
--
R
A
-----
H
S
E
Q
I
P
I
I
L
G
S
A
T
P
A
L
-
E
T
L
H
N
V
R
--
Q
--
G
--
K
--
Y
R
--
Q
L
T
-
L
S
K
P
A
Q
Q
--
H
---
V
L
--
D
L
K
--
G
---------
Q
P
L
--
Q
A
G
L
S
P
A
L
I
S
R
M
R
Q
H
L
---
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
Q
A
Q
H
H
L
R
C
H
H
C
D
S
Q
R
P
I
P
R
Q
C
P
S
C
G
S
T
H
-
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
L
A
P
-
L
F
P
-
E
V
P
I
S
R
I
D
R
H
L
A
--
A
V
H
-------
R
G
G
A
R
I
L
I
G
T
Q
----
M
L
A
K
G
H
H
F
P
D
-
V
T
L
V
S
L
L
D
V
D
G
-
A
L
F
S
A
D
F
R
S
A
E
R
F
A
Q
L
Y
T
Q
V
S
G
R
A
G
R
A
G
--
K
----
Q
G
E
V
I
L
Q
T
H
H
P
E
H
P
L
L
Q
T
L
L
----
Y
K
G
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
I
R
A
E
D
H
N
N
Q
Q
A
P
L
F
L
Q
Q
L
R
N
L
L
Q
A
S
P
L
A
D
E
-------------------
K
L
W
V
L
G
P
V
P
A
--------
L
R
W
Q
I
L
L
----
Q
H
P
S
------
R
V
R
L
Q
H
I
V
S
G
T
L
A
L
I
N
T
L
P
EAW
V
L
D
V
D
P
I
E
G
-
1
PsiBlast_PDB
82.69
35%
-82
- C2 -
4NL8
3
?
A:
[262-745]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
A
----
P
-
V
E
V
L
H
S
G
L
N
D
----
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
--------
T
R
S
S
L
F
--------
T
--------
P
------------
F
K
D
L
G
V
I
V
I
D
E
E
H
D
S
S
Y
K
Q
Q
-
E
---------
G
W
R
Y
H
A
R
D
L
A
V
---------
W
--
R
A
-----
H
S
E
Q
I
P
I
I
L
G
S
A
T
P
A
L
-
E
T
L
H
N
V
R
--
Q
--
G
--
K
--
Y
R
--
Q
L
T
-
L
S
----------------
Q
Q
--
H
--
V
L
D
---
L
K
G
Q
PL
Q
A
G
L
S
P
A
L
I
S
R
M
R
Q
H
L
---
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
Q
A
Q
H
H
L
R
C
H
H
C
D
S
Q
R
P
I
P
R
Q
C
P
S
C
G
S
T
H
-
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
L
A
P
------------------------------------------------------------
L
L
D
V
D
G
-
A
L
F
S
A
D
F
R
S
A
E
R
F
A
Q
L
Y
T
Q
V
S
G
R
-------
K
----
Q
G
E
V
I
L
Q
T
H
H
P
E
H
P
L
L
Q
T
L
L
----
Y
K
G
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
--------
I
R
A
E
D
H
N
N
Q
Q
A
P
L
F
L
Q
Q
L
--
R
N
L
L
Q
A
S
P
L
A
---------
D
E
K
L
W
V
L
G
P
V
P
A
L
A
-------
R
W
Q
I
L
L
Q
H
PS
R
V
R
L
Q
H
I
V
S
G
T
L
A
L
---
I
N
T
L
-----
V
K
W
---
V
L
D
V
D
P
I
E
G
-
53
HHSearch
61.15
24%
-98
- C2 -
1HV8
4
H669_METJA
A:
[73-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
I
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
KN
L
-
K
-
I
A
K
I
Y
G
G
K
A
I
----
Y
P
----
Q
I
K
---
A
L
K
N
A
N
I
V
V
G
--------
T
P
G
R
I
L
D
H
I
N
R
GT-
L
--------
N
------------
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
G
F
-
I
---------
K
-
D
V
----
E
K
I
---------
L
--
N
A
-----
C
N
K
D
K
R
I
L
L
F
S
A
T
M
P
R
-
E
I
L
N
L
A
K
--
K
YM
G
--
D
--
Y
S
--
F
I
---
K
A
K
I
N
---
A
---
N
I
---
E
Q
--
S
--
Y
V
E
---
V
N
E
--------
N
E
R
F
E
A
L
C
R
L
L
K--
N
K
E
F
Y
G
L
V
F
C
K
T
K
R
D
-------------------------------------------------------------
T
K
E
L
A
S
M
L
R
D
-
I
---
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
----
V
M
S
R
G
I
D
V
N
D
-
L
N
C
V
I
N
Y
H
L
P
Q
-
N
P
------------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
--
K
----
K
G
K
A
I
S
I
I
N
R
R
E
Y
K
K
L
R
Y
I
E
----
R
A
M
K
L
K
I
K
K
L
K
-----------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
59.68
21%
-71
- C2 -
1GM5
2
?
A:
[365-726]
---------------------------------------------------------------------------------------------------------------------------
L
P
F
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
SE
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
-------------------------------------------------------------------------------------------------------------
N
Y
---------
E
A
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
F
N
I
-
H
-
V
A
L
L
I
G
A
T
T
P
----
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
I
G
--------
T
H
A
L
I
Q
E
D
------
V
--------
H
------------
F
K
N
L
G
L
V
I
I
D
E
Q
H
R
F
------
E
---------
A
-------------------
L
--
M
N
-----
K
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
-
R
S
M
A
L
A
F
--
Y
--
G
--
D
--
L
D
--
V
T
V
-
I
D
E
M
P
P
G
--
R
---
K
E
--
V
Q
T
--
M
--
L
V
P
---
M
D
------
R
-
V
N
E
V
Y
E
F
V
R
Q
E
V
---
M
R
G
G
Q
A
F
I
V
Y
P
L
I
-------------------------------------------------------------
K
S
A
V
E
M
Y
E
Y
L
S
K
E
V
F
----
K
L
G
L
M
H
G
R
L
S
QE
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
I
L
V
S
T
T
----
V
I
E
V
G
I
D
V
P
R
-
A
N
V
M
V
I
E
N
P
E
R
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
G
G
--
Q
----
E
A
Y
C
F
L
V
V
G
D
V
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
K
Q
H
G
L
S
G
F
K
V
A
D
L
Y
R
D
L
K
L
L
E
W
-----------------------------------------------------------------------------------------------------------
48
HHSearch
57.72
19%
-71
- C2 -
3FHT
4
DD19B_HUMAN
A:
[94-379]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
----
Y
P
E
L
K
L
A
Y
A
V
R
G
--------
N
K
L
E
R
G
--
Q
K
I
S
E
Q
I
V
I
G
--------
T
P
G
T
V
L
D
W
C
SKLKF
I
--------
D
------------
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
G
-
H
---------
Q
D
----
Q
S
I
R
I
---------
Q
--
R
M
-----
L
P
R
N
C
Q
M
L
L
F
S
A
T
F
E
D
-
S
V
W
K
F
A
Q
--
K
--
V
--
V
PD
P
N
--
V
I
K
-
L
K
R
E
E
----
E
---
T
L
--
D
T
I
--
K
Q
Y
Y
V
L
---
C
S
S
R
--
D
E
K
F
-
Q
A
L
C
N
L
Y
G
-
A
----
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
-------------------------------------------------------------
A
S
W
L
A
A
E
L
S
K
-
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
----
V
C
A
R
G
I
D
V
E
Q
-
V
S
V
V
I
N
F
D
L
P
V
-
D
K
------
D
G
N
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
--
K
----
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
----
Q
E
H
F
N
K
K
I
E
R
L
-----------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
55.96
18%
-76
- C2 -
3PEY
10
DBP5_YEAST
A:
[74-361]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
-
T
-
S
Q
L
I
V
P
D
------------
S
F
E
K
N
--
K
Q
I
N
A
Q
V
I
V
G
--------
T
P
G
T
V
L
D
L
M
R
R
KL-
M
--------
Q
------------
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
-
L
---------
G
D
Q
C
----
I
R
V
---------
K
--
R
F
-----
L
P
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
-
A
V
R
Q
Y
A
K
--
K
--
I
V
P
N
--
A
N
--
T
L
E
-
L
Q
T
N
E
V
-------
N
V
--
D
A
I
K
Q
L
--
Y
M
D
---
C
K
N
E
--
A
D
K
F
--
D
V
L
T
E
L
Y
G
L
----
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
-------------------------------------------------------------
N
V
L
Y
G
K
L
K
S
-
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
----
V
L
A
R
G
I
D
I
P
T
-
V
S
M
V
V
N
Y
D
L
P
T
-
L
A
------
N
G
Q
A
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
--
R
----
K
G
V
A
I
S
F
V
H
D
K
N
S
F
N
I
L
S
A
I
----
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
-----------------------------------------------------------------------------------------------------------------------
58
HHSearch
55.67
23%
-74
- C2 -
2Z0M
-
?
A:
[56-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
S
L
V
V
T
P
T
R
E
L
T
R
Q
V
A
S
H
I
R
D
I
G
R
Y
MD
T
-
K
-
V
A
E
V
Y
G
G
M
P
Y
----
K
A
Q
I
N
R
-------
V
R
N
A
D
I
V
V
A
--------
T
P
G
R
L
L
D
L
W
S
K
GV-
I
--------
D
------------
L
S
S
F
E
I
V
I
I
D
E
A
D
L
M
F
E
M
G
F
-
I
---------
D
---
D
---
I
K
I
---------
I
--
L
A
Q
----
T
S
N
R
K
I
T
G
L
F
S
A
T
I
P
E
-
E
I
R
K
V
V
K
--
D
--
F
--
I
--
T
N
--
Y
E
E
-
I
E
A
C
I
G
---
L
---
A
N
--
V
E
H
--
K
--
F
V
H
---
V
K
D
D
-----
W
-
R
S
K
V
Q
A
L
R
E
-----
N
K
D
K
G
V
I
V
F
V
R
T
R
N
R
-------------------------------------------------------------
V
A
K
L
V
R
L
F
D
N
--------
A
I
E
L
R
G
D
L
P
Q
S
V
R
N
R
N
I
D
A
F
R
E
G
E
Y
D
M
L
I
T
T
D
----
V
A
S
R
G
L
D
I
P
L
-
V
E
K
V
I
N
F
D
A
P
Q
-
D
L
------------
R
T
Y
I
H
R
I
G
R
T
G
R
M
G
--
R
----
K
G
E
A
I
T
F
I
L
N
E
Y
W
L
E
K
E
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
55.60
17%
-80
* C2 *
3I5X
3
MS116_YEAST
A:
[146-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
NYGL
K
-
K
Y
A
C
V
S
L
V
G
G
----
T
D
F
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
--------
T
P
G
R
L
I
--------
D
V
L
E
K
YSNK
F
------------
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
G
F
-
R
----------
D
D
L
--
E
T
I
S
G
---------
I
--
L
N
E
K
NSK
S
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
-
K
V
Q
K
L
A
N
NI
M
--
N
--
K
--
K
E
--
C
L
F
-
L
D
T
V
D
K
N
EP
E
---
A
H
--
E
R
I
D
Q
S
--
V
V
I
---
S
E
K
F
--
A
N
S
I
-
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
-------------------------------------------------------------
T
S
F
L
C
S
I
L
K
N
-
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
----
V
G
A
R
G
M
D
F
P
N
-
V
H
E
V
L
Q
I
G
V
P
S
-
E
L
------------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
--
K
----
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
----
D
A
K
N
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
A
M
F
E
I
----
R
D
----------------------------------------
50
HHSearch
55.58
15%
-77
- C2 -
2DB3
3
VASA1_DROME
A:
[129-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
SY
L
-
K
-
I
G
I
V
Y
G
G
T
S
F
----
R
H
Q
----
N
E
C
--
I
T
R
G
C
H
V
V
I
A
--------
T
P
G
R
L
L
D
F
V
D
R
TF-
I
--------
T
------------
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
-------------
S
E
D
M
R
R
I
M
T
---------
H
--
V
T
-----
M
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
-
E
I
Q
R
M
A
G
--
E
F
L
K
--
N
--
Y
V
--
F
V
A
-
I
G
I
--
V
G
--
G
---
A
C
--
S
D
V
--
K
Q
T
I
Y
E
---
V
N
K
---
Y
A
K
-
R
S
K
L
I
E
I
L
S
------
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
-------------------------------------------------------------
A
D
F
L
A
S
F
L
S
E
-
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
----
V
A
S
R
G
L
D
I
K
N
-
I
K
H
V
I
N
Y
D
M
P
S
-
K
I
------------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
--
N
----
N
G
R
A
T
S
F
F
D
P
E
K
D
R
A
I
A
A
D
L
----
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
55.24
17%
-78
- C2 -
3SQW
3
MS116_YEAST
A:
[94-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
NYGL
K
-
K
Y
A
C
V
S
L
V
G
G
----
T
D
F
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
--------
T
P
G
R
L
I
--------
D
V
L
E
K
YSNK
F
------------
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
G
F
-
R
----------
D
D
L
--
E
T
I
S
G
---------
I
--
L
N
E
K
NSK
S
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
-
K
V
Q
K
L
A
N
--
N
IM
N
--
K
--
K
E
--
C
L
F
-
L
D
T
V
D
K
N
--
E
PE-
A
H
--
E
R
I
D
Q
S
--
V
V
I
---
S
E
K
F
--
A
N
S
I
-
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
-------------------------------------------------------------
T
S
F
L
C
S
I
L
K
N
-
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
----
V
G
A
R
G
M
D
F
P
N
-
V
H
E
V
L
Q
I
G
V
P
S
-
E
L
------------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
--
K
----
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
----
D
A
K
N
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
A
M
F
E
I
----
R
-----------------------------------------
44
HHSearch
55.12
15%
-75
- C2 -
1OYW
-
RECQ_ECOLI
A:
[65-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
G
V
-----
A
-
A
A
C
L
N
S
T
Q
T
R
----
E
Q
Q
L
E
V
M
T
G
C
--
R
T
G
Q
I
R
L
L
Y
I
--------
A
P
E
R
L
M
LDN
F
L
E
H
-
L
--------
A
------------
H
W
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
---------
R
P
E
Y
A
--
A
L
G
Q
---------
L
--
R
Q
-----
R
F
P
T
L
P
F
M
A
L
T
A
T
A
D
D
-
T
T
R
Q
D
I
V
--
R
-----
L
--
L
G
--
L
N
D
-
P
L
I
Q
I
S
S
--
F
---
D
R
--
P
N
I
--
R
--
Y
M
L
---
M
E
K
----
F
K
P
L
D
Q
L
M
R
Y
V
Q
E
-----
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
K
-------------------------------------------------------------
V
E
D
T
A
A
R
L
Q
S
-
K
---
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
----
A
F
G
M
G
I
N
K
P
N
-
V
R
F
V
V
H
F
D
I
P
R
-
N
I
------------
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
--
L
----
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
W
L
R
R
C
L
----
E
E
K
P
Q
G
Q
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
E
A
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
G
R
Q
E
P
C
G
N
C
D
I
C
L
D
P
P
K
Q
Y
D
G
S
T
D
A
Q
I
A
L
S
T
I
G
R
V
N
Q
R
F
G
M
G
Y
V
V
E
V
I
R
G
A
N
N
Q
R
I
R
D
Y
G
H
D
K
----
L
K
V
Y
G
M
G
R
D
K
S
H
E
H
W
V
S
V
I
R
Q
L
I
H
L
G
L
V
T
---
Q
N
I
A
Q
H
S
A
L
Q
45
HHSearch
55.06
14%
-72
- C2 -
2V1X
3
RECQ1_HUMAN
A:
[83-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
-----
S
-
A
T
M
L
N
A
S
S
S
K
----
E
H
V
K
W
V
H
A
E
M
V
N
K
N
S
E
L
K
L
I
Y
V
--------
T
P
E
K
I
A
--------
K
--------
S
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
H
-
D
----------
F
R
P
D
Y
K
A
L
G
I
---------
L
--
K
R
-----
Q
F
P
N
A
S
L
I
G
L
T
A
T
A
T
N
-
H
V
L
T
D
A
Q
--
K
I
L
C
--
I
--
E
K
--
C
F
T
-
F
T
A
S
F
--------
N
R
--
P
N
L
--
Y
--
Y
E
V
---
R
Q
K
P
SN
T
E
D
F
I
E
D
I
V
K
L
I
N
G
R
----
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
-------------------------------------------------------------
S
E
Q
V
T
V
S
L
Q
N
-
L
---
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
----
A
F
G
M
G
I
D
K
P
D
-
V
R
F
V
I
H
H
S
M
S
K
-
S
M
------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
--
M
----
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
R
I
S
S
M
V
----
V
M
E
N
V
G
Q
Q
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
A
C
N
K
M
C
D
N
C
C
K
D
S
A
F
E
R
K
N
I
T
E
Y
C
R
D
L
I
K
I
L
K
Q
A
E
E
L
N
E
K
L
T
P
L
K
L
I
D
S
W
M
G
K
G
A
A
K
L
R
V
A
G
V
V
A
P
----
T
L
P
R
E
D
L
E
K
I
I
A
H
F
L
I
Q
Q
Y
L
K
E
D
Y
S
F
T
A
Y
---
A
T
I
S
Y
L
K
I
G
P
54
HHSearch
54.43
14%
-90
- C2 -
2I4I
1
DDX3X_HUMAN
A:
[100-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
SR
V
-
R
-
P
C
V
V
Y
G
G
A
D
I
----
G
Q
Q
---
I
R
-
D
--
L
E
R
G
C
H
L
L
V
A
--------
T
P
G
R
L
V
--------
D
M
M
E
R
GKI-
G
------------
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
-
E
----------
P
Q
I
--
R
R
I
V
E
---------
Q
DT
M
P
-----
P
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
-
E
I
Q
M
L
A
R
--
D
--
F
LD
E
--
Y
I
--
F
L
A
-
V
G
----
T
--
S
---
E
N
--
I
T
Q
--
K
--
V
V
W
---
V
E
E
S
---
D
K
--
R
S
F
L
L
D
L
L
N
A
T
---
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
-------------------------------------------------------------
A
D
S
L
E
D
F
L
Y
H
-
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
----
V
A
A
R
G
L
D
I
S
N
-
V
K
H
V
I
N
F
D
L
P
S
-
D
I
------------
E
E
Y
V
H
R
I
G
R
T
G
R
----
N
----
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
T
K
D
L
L
----
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------------------------------------------------------
40
HHSearch
52.92
19%
-81
- C2 -
3EIQ
-
IF4A1_HUMAN
A:
[99-397]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
T
Q
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
Y
MG
A
-
S
-
C
H
A
C
I
G
G
T
N
V
----
R
---
A
E
V
Q
K
L
--
Q
M
E
A
P
H
I
I
V
G
--------
T
P
G
R
V
F
D
M
L
N
R
RY-
L
--------
S
------------
P
K
Y
I
K
M
F
V
L
D
E
A
D
E
M
L
S
R
G
F
-
K
---------
D
Q
I
Y
-----
D
I
---------
F
--
Q
K
-----
L
N
S
N
T
Q
V
V
L
L
S
A
T
M
P
S
-
D
V
L
E
V
T
K
--
K
--
F
--
M
--
R
D
--
P
I
R
-
I
L
V
K
K
E
E
--
L
---
T
L
--
E
G
I
--
R
Q
F
Y
I
N
---
V
E
R
E
--
E
W
K
L
-
D
T
L
C
D
L
Y
-
E
T
L
----
T
I
T
Q
A
V
I
F
I
N
T
R
R
K
-------------------------------------------------------------
V
D
W
L
T
E
K
M
H
A
-
R
---
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
----
L
L
A
--
I
D
V
Q
Q
-
V
S
L
V
I
N
Y
D
L
P
T
-
N
R
------------
E
N
Y
I
H
R
I
G
R
G
-------------
V
A
I
N
M
V
T
E
E
D
K
R
T
L
R
---------
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
-----------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
52.36
19%
-88
- C2 -
1S2M
-
DHH1_YEAST
A:
[114-392]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
CG
I
-
S
-
C
M
V
T
T
G
G
T
N
L
----
R
D
---
D
I
L
-
R
--
L
N
E
T
V
H
I
L
V
G
--------
T
P
G
R
V
L
D
L
A
S
R
KV-
A
--------
D
------------
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
-
K
----------
T
I
I
E
--
Q
--
I
---------
L
--
S
F
-----
L
P
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
-
T
V
K
E
F
M
V
--
K
--
H
--
L
--
H
K
PY
E
I
N
-
L
M
E
E
L
T
--------
L
--
K
G
I
--
T
Q
-
Y
Y
A
---
F
V
E
E
--
R
Q
K
L
--
H
C
L
N
T
L
F
S
K
----
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
-------------------------------------------------------------
V
E
L
L
A
K
K
I
T
D
-
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
----
L
L
T
R
G
I
D
I
Q
A
-
V
N
V
V
I
N
F
D
F
P
K
-
T
A
------------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
--
H
----
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
----
Q
E
L
G
T
E
I
A
A
I
P
A
T
I
D
K
S
L
Y
V
A
E
N
-----------------------------------------------------------------------------------------------------------------------------
47
HHSearch
52.34
16%
-88
- C2 -
1XTI
4
DX39B_HUMAN
A:
[76-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
MPN
V
K
-
V
A
V
F
F
G
G
L
S
I
----
K
K
D
E
E
V
L
-----
K
K
N
C
P
H
I
V
V
G
--------
T
P
G
R
I
L
A
L
A
R
N
KS-
L
--------
N
------------
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
D
-
M
---------
R
R
D
--
V
Q
E
--
I
---------
F
--
R
M
-----
T
P
H
E
K
Q
V
M
M
F
S
A
T
L
S
K
-
E
I
R
P
V
C
R
--
K
--
F
--
M
--
Q
D
--
P
M
E
I
F
V
D
D
E
T
K
--
L
---
T
L
--
H
G
L
Q
Q
Y
--
Y
V
K
---
L
K
D
----
N
E
K
N
R
K
L
F
D
L
L
D
-
V
L
----
E
F
N
Q
V
V
I
F
V
K
S
V
Q
R
-------------------------------------------------------------
C
I
A
L
A
Q
L
L
V
E
-
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
----
L
F
G
R
G
M
D
I
E
R
-
V
N
I
A
F
N
Y
D
M
P
E
-
D
S
------------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
--
T
----
K
G
L
A
I
T
F
V
S
D
E
N
D
A
K
I
L
N
D
V
----
Q
D
R
F
E
V
N
I
S
E
L
P
D
E
I
D
I
S
S
Y
I
E
Q
-----------------------------------------------------------------------------------------------------------------------------
59
HHSearch
49.37
15%
-72
- C2 -
2P6R
2
HELS_ARCFU
A:
[66-388]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
G
G
K
S
L
Y
V
V
P
L
R
A
L
A
G
E
K
Y
E
S
F
K
K
W
E
K
I
G
L
--
R
-
I
G
I
S
T
G
D
Y
E
S
----
R
D
E
---------
H
L
G
D
C
D
I
I
V
T
--------
T
S
E
K
A
D
--------
S
L
I
R
N
RAS-
W
------------
I
K
A
V
S
C
L
V
V
D
E
I
H
L
L
D
S
E
K
R
-----------
G
A
T
L
E
I
-
L
V
T
K
---------
M
--
R
R
-----
M
N
K
A
L
R
V
I
G
L
S
A
T
A
P
N
V
T
E
I
A
E
W
L
--
D
--
A
--
D
------
Y
Y
V
-
S
D
W
R
P
V
P
--
L
V
E
G
V
L
C
E
G
T
L
--
E
--
L
F
D
---
G
A
F
---
S
T
S
R
R
V
K
F
E
E
L
V
E
E
C
V
---
A
E
N
G
G
V
L
V
F
E
S
T
R
R
G
A
E
K
T
A
V
K
L
S
A
I
T
A
K
Y
V
---------
E
N
E
G
L
E
K
A
I
L
E
E
-------------
N
----------
E
G
E
M
S
R
K
L
A
E
-
C
V
--
R
K
G
A
A
F
H
H
A
G
L
L
N
G
Q
R
R
V
V
E
D
A
F
R
R
G
N
I
K
V
V
V
A
T
P
----
T
L
A
A
G
V
N
L
P
A
-
R
R
V
I
V
R
S
L
Y
R
------
F
D
G
Y
S
K
R
I
K
V
S
E
Y
K
Q
M
A
G
R
A
G
R
P
G
MD
E
----
R
G
E
A
I
I
I
V
G
K
R
D
R
E
I
A
V
K
R
Y
----
I
F
G
E
P
E
R
I
T
S
K
L
G
V
E
T
H
L
R
F
H
S
L
S
I
I
C
D
G
Y
A
K
T
L
E
E
L
E
D
F
F
A
D
T
F
F
F
K
Q
N
E
I
S
L
S
Y
E
L
E
R
V
V
R
Q
L
E
N
W
G
M
V
V
E
A
A
H
L
A
P
T
K
L
G
S
L
V
S
R
L
Y
I
D
P
L
T
G
F
I
F
H
D
V
----
L
S
R
M
E
L
S
D
I
G
A
L
H
L
I
C
R
T
P
D
M
E
R
L
T
V
R
K
T
---
D
S
W
V
E
E
E
A
F
R
65
Fugue
49.21
13%
-35
- C2 -
3I5X
3
MS116_YEAST
A:
[54-562]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
I
H
V
P
K
E
D
N
S
K
E
V
T
L
D
S
L
L
E
E
G
V
L
D
K
E
I
H
K
A
I
T
--
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
E
D
H
D
V
I
A
R
A
K
-
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
F
D
S
--
Q
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
----
N
-
Y
G
L
K
K
Y
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y
S
N
--------
K
--------
F
------------
F
R
F
V
D
Y
K
V
L
D
E
------
A
D
R
-
L
---------
L
E
I
G
F
R
D
D
L
E
T
---------
I
--
S
G
-----
I
L
N
E
K
---
N
S
K
S
A
D
N
I
-
K
T
L
L
F
S
A
--
T
--
L
--
D
--
D
K
--
V
Q
K
-
L
A
N
N
I
----
M
---
N
K
--
K
E
C
--
L
--
F
L
D
---
T
V
D
K
--
N
E
-------
P
E
A
H
E
R
I
---
D
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
--------------------------------
T
Q
N
--
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
----
V
G
A
R
G
M
D
F
P
N
-
V
H
E
V
L
Q
I
G
V
------------
P
S
E
L
A
N
Y
I
H
R
I
-
G
R
T
A
R
S
G
--
K
----
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
----
D
A
K
N
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
-----
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
----
A
M
F
E
I
R
D
-----------------------------------
57
HHSearch
47.71
17%
-64
- C2 -
2ZJ8
-
HELS_PYRFU
A:
[67-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
G
K
A
V
Y
I
V
P
L
K
A
L
A
E
E
K
F
Q
E
F
Q
D
W
E
K
I
G
L
--
R
-
V
A
M
A
T
G
D
Y
D
S
----
K
D
E
---------
W
L
G
K
Y
D
I
I
I
A
--------
T
A
E
K
F
D
S
L
L
R
H
GS-
S
--------
W
------------
I
K
D
V
K
I
L
V
A
D
E
I
H
L
I
G
S
R
D
R
-
G
----------
A
T
L
---
E
V
I
L
---------
A
--
H
------
M
L
G
K
A
Q
I
I
G
L
S
A
T
I
G
N
P
E
E
L
A
E
W
L
--
N
--
A
--
E
--
L
----
I
V
-
S
D
W
R
P
V
K
--
L
----
R
--
R
G
V
--
F
--
Y
Q
G
F
V
T
W
E
D
G
S
-
I
D
R
F
-
S
S
W
E
E
L
V
Y
D
A
I
---
R
K
K
K
G
A
L
I
F
V
N
M
R
R
K
A
E
R
V
A
L
E
L
S
K
K
V
K
S
L
L
T
K
P
---------------
E
I
R
A
L
N
E
---
L
A
D
------
S
L
E
-----
E
N
P
T
N
E
K
L
A
K
-
A
I
--
R
G
G
V
A
F
H
H
A
G
L
G
R
D
E
R
V
L
V
E
E
N
F
R
K
G
I
I
K
A
V
V
A
T
P
----
T
L
S
A
G
I
N
T
P
A
-
F
R
V
I
I
R
D
I
W
R
Y
-
S
----
D
F
G
M
E
R
I
P
I
I
E
V
H
Q
M
L
G
R
A
G
R
P
K
YD
E
----
V
G
E
G
I
I
V
S
T
S
D
D
P
R
E
V
M
N
H
Y
----
I
F
G
K
P
E
K
L
F
S
Q
L
S
N
E
S
N
L
R
S
Q
V
L
A
L
I
A
T
F
G
Y
S
T
V
E
E
I
L
K
F
I
S
N
T
F
Y
A
Y
Q
R
K
D
T
Y
S
L
E
E
K
I
R
N
I
L
Y
F
L
L
E
N
E
F
I
E
I
S
L
E
D
K
I
R
P
L
S
L
G
I
R
T
A
K
L
Y
I
D
P
Y
T
A
K
M
----
F
K
D
K
M
E
E
V
V
K
D
P
N
P
I
G
I
F
H
L
I
S
L
T
P
D
I
T
P
---
F
N
Y
S
K
R
E
F
E
R
56
HHSearch
46.07
14%
-60
- C2 -
3OIY
1
?
A:
[62-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
G
K
K
S
A
L
V
F
P
T
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
A
D
E
K
V
--
K
-
I
F
G
F
Y
S
S
M
K
K
----
E
E
K
E
K
F
E
K
S
F
--
E
E
D
D
Y
H
I
L
V
F
--------
S
T
Q
F
V
S
K
N
R
E
K
---
L
--------
S
------------
Q
K
R
F
D
F
V
F
V
D
D
V
D
A
V
L
K
A
S
R
-
N
I
D
T
L
L
M
M
V
G
I
P
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
--
P
K
-----
N
L
K
P
G
I
L
V
V
S
S
A
T
A
K
P
-
R
G
I
R
P
L
L
--
F
--
R
--
D
--
L
L
--
N
F
T
-
V
G
R
L
V
----
S
---
V
A
--
R
N
I
--
T
--
H
V
R
---
I
S
S
R
------
S
K
E
K
L
V
E
L
L
E
I
F
-----
R
D
G
I
L
I
F
A
Q
T
E
E
E
-------------------------------------------------------------
G
K
E
L
Y
E
Y
L
K
R
-
F
---
K
-----
F
N
V
G
E
T
WS
E
F
E
K
N
F
E
D
F
K
V
G
K
I
N
I
L
I
G
V
Q
A
YYG
K
L
T
R
G
V
D
L
P
E
R
I
K
Y
V
I
F
W
G
T
P
S
-
G
P
D
----------
V
Y
T
Y
I
Q
A
S
G
R
S
S
R
I
L
--
N
GVL
V
K
G
V
S
V
I
F
E
E
D
E
E
I
F
E
S
L
K
T
R
----
L
L
L
I
A
E
E
E
I
I
E
E
A
E
A
N
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
-------------------------------------------------------------------------------------------------------------------