@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0767: (2015-12-04 )
MLLSQEANSNSVEAQKLQQVDNITPSSEGLLQQMQSLEKRIKSLEVTNRVILGLFIGTLATAMTVGAGFAIAAAPIIAGSIVGGVLATVALVALGATVYRCRAQVEAGFRYAAEKTIKGVKYIGEKIKDSAIHTKDSVKEAVSSIGQVAREETSSVLKTMGHKLSGLGASMSNLDSIPYSIGLQDSMVVSKTEEKTKNFNSIKEMFVKEVFEDKAIDSSVLVKKIFSELKGKVLEKAYSVDGQQGFKKDQLINQLGQQADFVSKLSSKKLQNLLAQGDNNLYEIFSEHHDEIKRIVKEHKTEHNFSESLNRMAKRHDENRKDSTQSSLPRSNSLSSVRTDSTVNSVAELLNSEGHRKVRSSSKLLRWLPWNKVSKAPEEAANVKYQVLPESDILAREIGKRTFYGIPVPAEGVDKTVTVNPNLFRSNSPNSLYGSPVLTPAVLLQVPKSLSLGSLSSDSGMDSGPSTLEKQSLSPEDLAKARASLKNTGSLGKLVEQQPSASPPAVEDVSEDLEEDFKKDKPATTFSQLKAEKSGAEVSYL
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------.........---10........20-------..------.......30......--..40...-----.....50-----.......---------..60....---------------------------...-----------.70.....--...80..--------..--...----.90......-------..----100----........110.......120.-------.....---.130--....--...----.140.......-----150----........160......--.170------.......180.-----..-.....------190.......200.----..-..--.------..210....-----...-------220----------.......230----..-......---240---........-.250.......260......---------.270-......----------..280------------------........--290......---.-300..--......310.-......320......-.330.......340.......350--...----....360.......-370.....-..380........-------.390.........---400.......410.......420.........430-----.----------------.......-----.440.......450----------....---..--.--.460.....-...470---....-----....480.......490.----..------------.--------.....500-.---......---510--------.....--------...-------------------------------520----.........530....----...540-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------MLLSQEANS---N
S
V
E
A
Q
K
L
Q
Q
V
--------DN------ITP
S
S
E
G
L
L
Q
Q
M
Q
S
L
--
E
K
R
I
K
S
L
-----
E
VT
N
R
V
------
I
L
G
L
F
I
G
---------
T
L
A
T
A
M
T
V---------------------------GAG-----------
F
A
I
A
A
A
P
I
--
I
A
G
S
I
V
G
--------
G
V
--
L
A
T
----
V
A
L
V
A
L
G
A
T
-------
V
Y
----
R
C
-----
R
A
Q
V
E
A
G
F
R
Y
A
A
E
K
T
I
K
G
V
K
Y
I
-------
G
E
K
IK---DSA---IH
T
K
--
D
S
V
----
K
E
A
V
S
S
I
G
Q
V
A
-----
R
E
-----
E
T
S
S
V
L
K
T
M
G
H
K
L
SGLG--A
S
M
S
------NLDSI
P
Y
SI-G-----LQ-D
S
M
V
V------S
K
T
E
E
K
TK
N
F
N
-
S
I
----
K
E
-
M
F
--
V
------
K
E
V
F
EDKAI-----
D
S
S
-------
V
L
V
----------
K
K
I
F
S
E
L
K
G
-----
K
V
-
L
E
K
A
YS---V-----DGQQGF
K
K
-
D
Q
L
I
N
Q
L
G
Q
Q
A
D
F
V
S
K
L
S
S
K
---------
K
L
Q
--
N
L
L
A
QG----------D
N
N
L
-------------------
Y
E
I
F
S
E
H
H
--
D
E
I
K
R
I
V
K
E
---H-K-TEH--
N
F
S
E
S
L
N
R
M
A
-
K
RHDENRKDS
T
Q
SSL-PRSNSLSSVRTD
S
T
V
N
S
V
A
E
L
L
NS--EGH----
R
K
V
R
S
SS
K
L
L
RWLP-W
N
K
VSKA
P
-
E
E
A--AN
V
K
Y
Q
VL-------PE--S
D
I
L
A
R
E
IG---KRTFYGIPVPAEGVD
K
T
V
T
VN--PNLFRSNSPN-------S----------------LYGSPVL-----
T
P
A
V
L
L
QVPKSLS-----------LGSL---SS--D--SG-MDSGPS-
T
L
E
KQ----SL
S
P
-----
E
D
L
A
K
A
R
A
SLKNTG
S
--
L
----
G
K
------------
L
--------
V
E
QQPSAS-P---P
A
V
E
D
V
---
S
E
---------
D
L
E
E
D
--------
F
KK-------------------------------D------KPA
T
T
F
S
Q
L
K
AEKSGA----EVSYL------------------------
43
Fugue
89.86
16%
5
- C10 -
4RIC
5
FAN1_HUMAN
A:
[1-631]
------------------------------------------------------------------------------TGHP
Y
Y
L
R
S
F
L
V
V
L
K
T
V
L
E
N
E
D
D
M
L
L
F
D
E
Q
E
K
G
I
V
T
K
F
--------
Y
Q
------
L
S
A
T
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Q
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L
Y
V
R
L
F
Q
R
--
K
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M
-----
T
K
L
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Y
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------
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A
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D
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---------
P
V
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N
----------------------------
A
G
-----------
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L
--------
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L
--
L
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----
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L
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-------
F
H
----
L
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NPNGQ
K
Q
Q
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D
A
F
L
K
L
A
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Q
R
S
V
I
G
A
V
I
-------
L
K
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A
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---
A
L
A
G
Q
S
V
R
I
C
--
K
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P
----
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L
L
L
F
S
LTDS
M
E
-----
D
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D
A
A
C
G
G
Q
G
Q
L
S
T
V
L
L
--
V
N
L
G
------
R
M
E
F
P
S
Y
T
I
-
N
R
K
T
HI
F
Q
-
D
R
D
D
L
------
I
R
Y
A
A
A
T
H
M
L
S
-
D
I
----
S
S
-
A
M
--
A
------
N
G
-
N
W
E
E
A
K
-----
E
L
A
-------
Q
C
A
----------
K
R
D
W
N
R
L
K
N
-----
H
------------------------------
P
S
L
R
C
H
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D
L
P
L
F
L
R
C
F
---------
T
V
G
--
W
I
Y
T
R
I
----------
L
S
R
F
-------------------
V
E
I
L
Q
R
L
H
M
Y
E
E
A
V
R
E
L
E
S
---
L
L
S
-
Q
R
I
--
Y
C
P
D
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R
G
R
W
W
-
D
R
L
A
L
N
L
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-
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Y
--
Q
R
A
----
V
R
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Q
Q
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A
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R
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-------
C
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--
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F
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V
L
C
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---
V
E
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L
A
L
A
H
Y
R
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F
D
Q
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--
G
S
T
F
S
T
L
Y
G
L
-------
L
----------------
L
W
D
I
I
F
M
DG---
I
P
D
V
F
R
N
A
C
Q
A
F
P
-----------
L
D
-
L
---
C
T
--
D
--
S
F
-
F
T
S
R
R
P
-
A
L
E
A
R
L
Q
L
I
H
D
A
P
-----
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S
L
R
A
W
V
A
A
T
W
H
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Q
--
E
----
G
R
VASLVSWDRFTS
L
--------
Q
Q
A
Q
D
L
V
S
-
C
L
G
G
P
V
L
S
G
V
---
C
R
---------
H
L
A
A
D
--------
F
R
H
CRGGLPD
L
V
V
W
N
SQSR
H
F
K
L
V
E
V
K
G
PNDRLS
H
------
K
Q
M
I
W
L
A
E
L
Q
K
L
G
A
E
V
----
E
V
C
H
V
V
A
V---------------------
36
Fugue
84.33
14%
-3
* C10 *
4UZY
2
?
A:
[9-650]
------------------------------------------------------------------------------QQPA
R
P
I
A
EGQ
Y
T
Q
T
I
Y
T
L
I
K
E
Q
K
---
F
A
E
A
I
Q
H
L
Q
Y
Q
--------
L
Q
------
N
V
P
E
S
R
A
A
L
S
L
L
G
Y
C
--
Y
Y
Y
T
G
Q
Y
-----
D
M
A
S
Q
M
------
Y
E
Q
L
V
T
L
Y
P
SN
E
D
Y
K
L
Y
Y
A
Q
S
L
Y
K
---------------------------
G
G
M
-----------
Y
P
E
A
S
K
A
V
V
K
V
E
G
H
Q
K
A
--------
V
T
--
T
L
L
----
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A
C
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Y
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Q
D
D
-------
L
T
----
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C
-----
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R
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A
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P
D
T
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-------
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---
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E
A
---
A
R
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N
D
Y
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----
P
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L
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Y
N
I
A
L
C
Y
-----
Y
K
TKQ
F
G
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A
L
K
H
L
A
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I
I
E
K
A
V
R
E
H
--
P
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VGSDGM
E
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R
S
V
G
N
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Q
-
T
-----
L
K
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A
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A
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N
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K
A
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Y
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M
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N
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A
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----
K
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-
A
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--
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D
MPPRA
E
E
E
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D
P
V
T
L
-----
H
N
S
-------
A
L
I
N
M
DSD
P
T
G
G
F
K
K
L
N
F
L
L
Q
S
PPFPP
E
T
-
F
A
N
L
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---
L
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C
---
K
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Y
-
D
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D
V
L
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L
L
S
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---------
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L
Y
--
D
Y
L
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A
A
I
G
R
YKS
P
E
E
A
F
R
R
F
-------------------
D
E
L
A
T
R
H
V
--
E
Q
L
R
R
L
T
K
Q
---
I
-
Q
-
D
A
R
I
A
R
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N
D
A
I
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R
A
I
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N
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A
L
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L
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A
M
A
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Y
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E
K
I
F
R
Q
S
A
E
FC
S
E
H
----
E
V
W
K
L
N
V
A
H
T
F
F
M
Q
-
D
N
H
Y
K
E
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I
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R
Y
Y
--
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--
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N
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A
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---
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L
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A
E
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M
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K
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K
E
E
E
R
-------
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----------------
S
M
Q
D
P
-------
D
K
P
C
F
H
L
C
I
I
N
L
V
-----------
I
G
T
L
---
Y
C
--
A
--
K
G
N
Y
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F
G
V
S
-
R
I
I
K
S
----
L
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-----
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T
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Y
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A
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R
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F
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A
L
----
I
----
E
N
------------
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--------
A
K
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M
I
V
L
K
-
D
---
S
S
F
T
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---
M
A
---------
F
L
N
E
A
--------
E
K
H
-------------------------------
G
------
K
D
I
R
V
V
F
N
-
Q
S
R
T
I
A
S
----
E
A
R
M
L
K
K
M
F
L
K
L
R----------------
35
Fugue
81.66
13%
1
- C11 -
4UI9
-
ANC2_HUMAN
N:
[15-730]
----------------------------------------------------------------------------------------RPGQE
L
L
V
A
W
N
T
V
S
---
T
E
E
L
R
A
A
V
E
V
L
--------
R
G
HVLEEW
F
V
E
V
L
Q
N
D
L
Q
A
N
I
S
P
--
E
F
W
N
A
I
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-----
Q
C
E
N
S
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------
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L
L
L
L
L
D
---------
A
F
G
L
L
E
S
R
---------------------------
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D
P
-----------
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L
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L
L
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K
W
T
R
L
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LLMGTGAQ
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L
--
R
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----
V
H
T
M
L
R
G
V
L
-------
F
F
STPR
T
F
-----
Q
E
M
I
Q
R
L
Y
G
C
F
L
R
V
Y
M
Q
S
K
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K
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-------
D
P
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L
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GEL
D
S
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---
Y
A
R
R
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L
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L
W
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L
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Q
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L
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R
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A
V
T
T
T
L
H
Q
-
V
-----
T
R
-
E
R
M
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D
------
R
C
R
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Y
E
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----
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-
K
W
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R
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VFTLR
R
W
R
-------
C
H
V
----------
Q
R
F
F
Y
R
I
Y
A
-----
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L
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I
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L
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---
I
VRDFP
D
S
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P
A
I
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K
Y
C
L
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T
D
Q
R
Q
Q
L
L
V
S
L
K
A
A
---------
L
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T
--
R
L
L
H
P
G
----------
V
N
T
C
DIITLYISAIKALRVIDPS
M
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A
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--
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---
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L
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L
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F
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I
--
R
N
V
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L
K
L
RFGEAPM
H
F
--
C
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V
M
L
K
D
M
A
---
D
S
R
R
I
N
A
N
I
R
E
E
D
E
K
R
P
A
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--
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P
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Y
A
V
I
L
-------
S
SEFWPPFKDEKLEVPE
D
I
R
A
A
L
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-----
A
Y
C
K
K
Y
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Q
L
K
A
M
R
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T
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---
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H
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--
L
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-
L
V
T
M
D
V
-
E
L
A
D
R
----
T
L
S
V
AVTPV
Q
A
V
I
L
L
Y
F
Q
D
Q
A
S
W
T
--
L
----
E
E
------------
L
--------
S
K
A
V
K
M
P
V
-
A
---
L
L
R
R
R
M
---
S
V
---------
W
L
Q
Q
G
--------
V
L
R
-------------------------------
E
------
E
P
P
G
T
F
S
V
I
E
E
E
R
P
Q
D
----
R
D
N
M
V
LI----------------------
39
Fugue
81.19
15%
-17
* C9 *
5CA8
2
?
A:
[27-687]
------------------------------------------------------------------------------------------DAI
Q
I
I
D
E
N
K
H
F
---
N
T
---
G
I
L
D
Y
I
--------
N
K
------
T
S
P
A
D
V
G
N
N
Y
H
I
I
S
V
F
G
S
Q
S
T
G
K
S
-----
T
L
L
N
R
L
FNTNFD
V
M
G
I
W
L
A
---------
Y
S
P
V
V
S
T
T
L
G
H
T
T
S
KS
N
I
L
V
M
D
V
E
GTDED
Q
D
F
E
R
K
A
A
L
-----------
F
A
L
S
T
S
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V
--
L
I
I
N
I
W
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--------
T
Q
VG
L
Y
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----
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A
N
M
G
L
L
K
T
-------
V
F
----
E
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-----
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L
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L
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DHVG
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---
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---
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--
L
D
L
----
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N
M
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L
A
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P
A
-----
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-----
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H
L
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A
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T
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A
L
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--
H
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------
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P
K
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E
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I
-
N
R
----
L
G
-
D
R
L
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------
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N
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L
F
K
P
E
Y
H
H
-
D
V
PIDG
W
T
-
M
Y
--
A
------
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R
C
W
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Q
I
E
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-----
N
K
D
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L
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L
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----------
A
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D
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-----
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-
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---
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-----
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A
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A
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L
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D
---------
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--
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Y
D
A
S
A
----------
S
R
Y
N
-------------------
K
A
V
Y
E
Q
K
R
--
K
K
L
R
W
L
I
N
D
K
L
K
E
-
V
-
F
D
V
--
H
A
K
N
L
C
N
T
L
L
-
E
K
F
E
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D
L
V
A
L
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K
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-
A
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N
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T
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L
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E
D
V
N
F
Q
V
S
L
M
S
L
--
Q
G
D
LSL
D
E
I
I
L
A
L
T
K
D
I
D
A
I
V
-
A
K
Q
Q
V
V
E
L
-
N
S
I
--
V
N
K
S
V
K
K
L
-------
S
A
S
L
S
K
S
I
Q
F
E
L
G
DPN
E
E
T
W
D
N
V
L
Q
Q
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K
G
V
Y
E
K
F
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G
D
--
F
G
L
G
T
S
S
T
Q
N
Q
Q
A
I
E
KF
K
----------------
F
K
S
W
C
Q
F
-----
Y
D
V
T
H
K
L
I
S
R
E
K
L
-----------
L
A
L
L
---
Q
D
R
F
D
--
D
K
-
F
R
Y
D
E
N
-
G
L
P
K
L
----
Y
L
N
E
-----
Q
D
L
E
K
T
F
A
V
A
K
Q
H
A
L
Q
V
L
----
P
I
------------
L
--------
T
F
A
K
L
A
D
G
-
S
---
E
I
V
P
D
Y
DIF
D
S
---------
K
L
R
E
Q
--------
F
L
D
-------------------------------
H
CFAEII
T
E
Q
E
K
L
E
V
L
A
K
F
K
K
E
V
----
D
A
K
Y
I
E
T
K
R
S
I
V-----------------
41
Fugue
81.01
17%
-12
- C7 -
4UI9
-
APC4_HUMAN
I:
[6-757]
TCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKP
E
S
L
H
S
F
S
V
E
---
A
P
V
S
C
M
H
W
M
E
V
TVESSVLT
S
F
------
Y
E
D
E
S
N
L
L
L
P
K
L
P
T
L
--
P
K
N
Y
S
N
T
SKIFS
E
E
N
S
D
E
------
I
I
K
L
L
G
D
---------
V
R
L
N
I
L
V
L
---------------------------
G
G
S
SGFIELYAYGM
F
K
I
A
R
V
T
G
--
I
A
G
T
C
L
A
--------
L
C
--
L
S
S
DLKS
L
S
V
V
T
E
V
S
T
NGASEVS
Y
F
----
Q
L
-----
E
T
N
L
L
Y
S
F
L
P
E
V
T
R
M
A
R
K
F
T
H
I
-------
S
A
L
L
Q
---
Y
I
N
---
L
-
S
L
--
T
C
M
----
C
E
A
W
E
E
I
L
M
Q
M
-----
D
S
-----
R
L
T
K
F
V
Q
E
K
N
T
T
T
S
V
Q
D
--
E
F
M
H
------
L
L
L
W
G
K
A
S
A
-
E
-----
L
Q
-
T
L
L
M
N
------
Q
L
T
V
K
G
L
K
K
L
G
Q
S
I
----
E
S
-
S
Y
SS
I
------
Q
K
L
V
I
S
H
L
Q
-----
S
G
S
-------
E
S
L
----------
L
Y
H
L
S
E
L
K
G
-----
M
A
S
W
K
Q
K
Y
E
-----------
P
L
G
L
D
A
-
A
G
I
E
E
A
I
T
A
V
G
S
F
I
--
L
K
A
N
---------
E
L
L
--
Q
V
I
D
S
S
----------
M
K
N
F
-------------------
K
A
F
F
R
W
L
Y
--
V
A
M
L
R
M
-
T
D
---
K
-
M
-
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Q
K
--
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I
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A
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L
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-
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N
F
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D
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D
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-
P
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N
T
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N
Q
W
Y
D
F
L
Q
N
--
S
S
H
----
L
K
E
--
S
P
L
L
F
P
Y
Y
P
-
R
K
S
L
H
F
V
K
-
R
R
M
--
E
N
I
I
D
Q
C
L
-------
Q
K
P-
A
D
V
I
G
K
S
M
N
---
Q
A
I
C
I
P
L
Y
R
D
T
R
S
E
D
S
T
R
R
L
F
KF
P
F
L
W
N
N
K
T
S
N
-------
L
----------------
H
Y
L
L
F
T
I
LEDSL
Y
K
M
C
I
L
R
R
H
T
D
I
S
QSVSNGLIAIK
F
G
S
F
TYA
T
T
--
E
--
K
V
-
R
R
S
I
Y
S
-
C
L
D
A
Q
----
F
Y
D
D
-----
E
T
V
T
V
V
L
K
D
T
V
G
R
E
G
--
R
----
D
R
------------
L
--------
L
V
Q
L
P
L
S
L
-
V
---
Y
N
S
E
D
S
---
A
E
YQFTGTYST
R
L
D
E
Q
CSAIPTRT
M
H
F
-------------------------------
E
------
K
H
W
R
L
L
E
S
M
K
A
Q
Y
V
A
G
NGFR
K
V
S
C
V
LSSNLRHVRVFEMDIDDEWELDES
37
Fugue
78.81
16%
-6
- C11 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
----------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
--------
L
G
------
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
--
L
R
A
-
R
S
I
-----
R
C
L
R
N
I
------
I
H
A
N
L
I
A
---------
A
F
I
L
R
N
A
T
---------------------------
W
F
V
-----------
V
Q
L
T
M
S
P
E
--
V
H
Q
S
N
V
G
--------
W
C
--
R
L
V
----
T
A
A
Y
N
Y
F
H
V
-------
T
N
----
F
F
-----
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
-------
R
I
D
E
G
---
L
R
L
---
K
I
Y
K
--
D
T
E
----
G
Y
Y
T
I
G
I
G
H
L
L
-----
T
K
-----
S
P
S
------------
L
S
--
V
A
K
S
------
E
L
D
K
---
A
I
-
G
-----
R
N
-
S
N
G
V
I
------
T
-
K
D
E
A
E
K
L
F
N
-
Q
D
----
V
D
-
A
A
--
V
------
R
G
I
L
R
N
A
K
------------------
L
----------
K
P
V
Y
D
S
L
D
------------------------------------------------
A
V
R
R
S
---------
A
L
I
--
N
M
V
F
Q
M
----------
G
E
T
G
-------------------
V
A
G
F
T
N
S
L
--
R
M
L
Q
Q
-------------
K
--
R
W
D
E
A
A
V
N
L
A
-
K
S
R
W
Y
N
Q
-------------------
T
P
N
R
A
K
R
V
I
A
T
F
R
T
--
G
-------------------
T
-
W
D
A
Y
D
R
L
R
-
A
W
M
--
F
I
C
I
G
W
G
V
-------
P
F
--
P
I
I
V
A
W
A
I
G
---
K
L
Y
Y
D
---------------
N
--
E
K
C
W
A
G
K
R
P
G
-------
V
----------------
Y
T
D
Y
I
Y
Q
-----
G
P
M
A
L
V
L
L
I
N
F
I
F
-----------
L
F
N
I
---
V
R
--
I
--
L
M
-
T
K
L
R
A
S
-
T
-----------
T
-----
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
--
L
----
L
P
------------
L
--------
L
G
I
T
Y
M
L
A
F
V
---
N
E
V
S
R
V
---
V
F
---------
I
Y
F
N
A
--------
F
L
E
-------------------------------
S
------
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
----------------------------------
40
Fugue
66.14
12%
4
- C5 -
1I8T
1
GLF_ECOLI
A:
[1-367]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
D
Y
I
I
V
---------------------------
G
S
G
--------------------------
L
F
--------
G
A
--
V
C
A
----
N
E
L
K
K
L
N
K
K
-------
V
L
----
V
I
-----
E
K
R
N
H
I
G
-
G
N
A
Y
T
E
D
C
E
G
I
Q
I
H
-------
K
Y
G
A
H
----
I
F
---
H
T
N
D
--
K
Y
I
----
W
D
Y
V
N
D
L
V
E
F
N
-----
R
F
-----
T
N
S
P
L
A
I
Y
K
D
K
L
F
N
L
P
F
N
M
N
T
F
H
------
Q
M
W
G
V
K
D
P
Q
-
E
-----
A
Q
-
N
I
I
N
A
------
Q
K
K
K
Y
G
D
K
V
P
E
-
N
L
----
E
E
-
Q
A
--
I
------
S
L
V
G
---------------------------------
E
D
L
Y
Q
A
L
I
K
-----
G
Y
-
T
E
K
Q
W
G
---
R
-----
S
A
K
E
--
L
P
-
A
F
I
I
K
R
I
P
V
R
F
T
F
D
N
N
Y
F
S
D
---------
R
Y
Q
--
G
I
P
V
G
G
----------
Y
T
K
L
-------------------
I
E
K
M
L
E
-------------------------
G
V
D
V
K
L
G
I
D
F
-
L
K
D
K
D
S
L
A
S
K
A
H
R
I
I
-
Y
-------------
T
G
P
I
D
Q
Y
F
D
Y
--
R
F
G
----
A
------------------------------
L
E
Y
R
S
L
-------
K
F
--
E
T
E
R
H
E
F
P
N
---
F
Q
G
N
A
V
I
N
F
T
D
A
N
V
P
Y
T
R
I
I
E
--
H
K
H
F
D
Y
V
E
T
K
-------
H
-----------------------------
T
V
V
T
K
E
Y
P
L
E
W
K
-----------
V
G
D
--------------
E
P
Y
Y
P
V
-
N
D
N
K
N
----
M
E
L
F
-----
K
K
Y
R
E
L
A
S
R
E
D
K
V
I
F
--
G
----
G
R
------------
L
--------
A
E
Y
K
Y
Y
D
M
-
H
---
Q
V
I
S
A
A
---
L
Y
---------
Q
V
K
N
I
--------
M
S
T
-------------------------------
D
-------------------------------------------------------
38
Fugue
52.96
28%
59
* C11 *
1ZV1
-
DSX_DROME
A:
[6-64]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
V
F
L
D
Y
C
Q
K
L
L
E
K
F
RYPWEL
M
P
L
M
Y
--
V
I
L
K
D
A
----------
D
A
N
--------------------
I
E
E
A
S
R
R
I
--
E
E
G
Q
Y
V
V
N
E
---
Y
-
S
-
R
Q
H
--
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
52.32
12%
27
- C9 -
3QOE
-
?
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
D
V
D
L
I
K
R
L
G
-
P
S
----
A
M
-
D
Q
--
I
------
M
L
Y
L
A
F
S
A
M
-----
R
T
S
-------
G
H
R
----------
H
G
A
F
L
D
A
A
A
-----
T
A
-
A
K
C
A
I
Y
---
M
-----
T
Y
L
E
Q
G
Q
N
-
L
R
M
T
G
H
L
H
H
L
E
P
K
R
V
K
A
I
V
E
---------
E
V
R
--
Q
A
L
T
E
G
-----------
K
L
L
-------------------
K
M
L
G
S
Q
E
P
--
R
Y
L
I
Q
F
P
Y
V
---
W
-
M
-
E
K
Y
--
P
W
R
P
G
R
S
R
I
P
G
T
S
L
T
S
E
E
K
R
Q
I
E
Q
K
L
-
P
S
N
L
P
D
A
H
L
I
T
S
F
E
F
L
E
L
I
E
F
L
H
K
--
R
S
Q
----
E
D
L
P
K
E
H
Q
M
-----------------------------------
P
L
--
S
E
A
L
A
E
H
I
K
---
R
R
L
L
Y
---------
S
G
T
V
T
R
I
--
D
S
P
W
--
G
M
P
F
-------
Y
----------------
A
L
T
R
D
Q
E
-----
R
T
Y
I
M
V
E
D
T
A
R
F
F
-----------
R
M
M
R
---
D
W
--
A
--
E
K
-
R
P
N
T
M
R
-
V
L
E
E
L
----
D
I
L
P
-----
E
K
M
Q
Q
A
K
D
E
L
D
E
I
I
R
--
A
----
W
A
------------
D
--------
P
V
V
L
Q
M
V
F
-
G
---
K
K
-------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.45
22%
-15
- C8 -
4L6Y
-
PRC1_HUMAN
A:
[19-146]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
--
K
A
L
N
------
H
L
R
E
I
W
E
L
I
-
G
-----
I
P
-
E
D
Q
R
L
------
Q
R
T
E
V
V
K
K
H
I
K
-
E
L
----
L
D
-
M
M
--
I
A
E
----
E
E
S
L
K
E
R
L
I
-----
K
S
I
-------
S
V
C
----------
Q
K
E
L
N
T
L
C
S
-----
E
L
-
H
V
E
P
F
Q
---
E
-----
E
G
E
T
T
I
L
---
Q
L
E
K
D
L
R
T
Q
V
E
L
M
R
K
Q
K
K
E
---------
R
K
Q
E
L
K
L
L
Q
E
Q
----------
D
Q
E
L
-------------------
C
E
I
L
C
M
P
H
--
Y
D
I
D
S
A
S
V
P
---
S
-
L
-
E
E
L
--
N
Q
F
R
Q
H
V
T
T
L
-
R
E
T
K
A
S
R
R
E
E
F
V
S
I
K
-
R
Q
I
I
L
C
M
E
E
L
D
H
T
P
D
T
S
F
E
R
D
V
V
C
--
E
D
E
----
D
A
F
C
L
S
L
E
N
I
A
T
L
Q
-
K
L
L
R
Q
L
E
M
-
Q
K
S
--
Q
N
E
A
V
C
E
G
-------
L
R
--
T
Q
I
R
E
L
W
D
R
---
L
Q
I
P
E
E
E
R
E
A
V
A
T
I
M
S
G
S
K
A
K
--
V
R
K
A
L
Q
L
E
V
D
-------
R
----------------
L
E
E
L
K
M
Q
-----
N
M
K
K
V
I
E
A
I
R
V
E
L
-----------
V
Q
Y
W
---
D
Q
--
C
--
F
Y
-
S
Q
E
Q
R
Q
-
A
F
A
P
F
----
C
A
E
Y
-----
T
E
S
L
L
Q
L
H
D
A
E
I
V
R
L
--
K
----
N
Y
------------
Y
--------
E
V
H
K
E
L
F
E
-
G
---
V
Q
K
W
E
E
---
T
W
---------
R
L
F
L
E
--------
F
E
R
-------------------------------
K
------
A
S
D
P
N
R
R
G
G
N
L
L
K
E
E
K
----
Q
R
A
K
L
------------------------
7
PsiBlast_PDB
45.90
31%
117
- C6 -
4HPP
-
?
A:
[24-115]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
P
-----------
L
A
T
L
---
E
E
--
Q
LA
S
G
-
C
G
W
V
P
A
----
N
S
----
S
L
T
P
-----
Q
D
L
I
D
E
S
S
P
W
G
S
H
G
D
--
L
----
R
L
------------
L
PDPNSRVR
V
E
Q
G
P
D
A
A
-
A
---
P
A
L
D
Y
L
---
H
G
---------
N
L
V
E
T
--------
D
G
T
-------------------------------
P
------
W
P
A
C
P
R
S
L
L
R
A
E
V
E
R
Y
----
R
D
S
G
L
------------------------
15
PsiBlast_PDB
42.35
34%
108
- C4 -
2FJH
-
?
L:
[40-115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
K
-----
A
P
K
L
L
I
Y
A
A
S
N
L
A
-----------
S
G
V
P
---
S
R
--
F
--
S
G
-
S
G
S
G
T
D
F
T
L
T
I
S
----
S
L
Q
P
-----
E
D
F
A
T
Y
Y
C
Q
Q
S
N
T
S
P
--
L
TFGQ
G
T
------------
K
--------
V
E
I
K
R
T
V
A
-
A
---
P
S
V
F
I
F
---
P
P
---------
S
D
E
Q
L
--------
K
S
G
-------------------------------
T
------
A
S
V
V
C
L
L
N
N
F
Y
P
R
E
A
K
----
V
Q
W
K
V
------------------------
12
PsiBlast_PDB
42.25
30%
60
- C8 -
2JS1
-
YVFG_BACSU
A:
[1-56]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
------
E
L
F
S
V
P
Y
F
I
E
N
-----
L
K
-
Q
H
I
E
M
------
N
Q
S
E
D
K
I
H
A
M
N
-
S
Y
----
Y
R
-
S
V
--
V
------
S
T
L
V
Q
D
Q
L
T
-----
K
N
A
-------
V
V
L
----------
K
R
I
Q
H
L
D
E
A
-----
Y
N
-
K
V
K
R
G
E
---
S
-----
K
L
E
H
H
H
H
H
-
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
40.37
15%
77
- C8 -
1YGM
-
MSTX_BACSU
A:
[26-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
K
V
T
S
E
E
-----
K
E
-----
Q
L
S
T
A
I
D
R
M
N
E
G
L
D
A
F
I
--
Q
--------------
L
Y
N
E
-
S
-----
E
I
-
D
E
P
L
I
------
Q
L
D
D
D
T
A
E
L
M
K
-
Q
A
----
R
D
-
M
Y
--
G
------
Q
E
K
L
N
E
K
L
------
N
---------
T
I
I
----------
K
Q
I
L
S
I
S
V
S
-----
E
E
-
G
E
K
E
L
V
---
P
-----
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
40.21
32%
133
- C8 -
2JQE
-
SRP54_ARCFU
A:
[328-385]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
M
G
--
P
V
R
K
------
I
F
E
M
L
P
F
G
L
-
G
-----
L
K
V
D
N
D
V
M
------
E
M
T
Q
E
K
M
K
K
F
R
-
V
I
----
M
D
S
M
T
--
E
------
E
E
L
L
N
P
K
I
I
-----
D
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
37.40
35%
270
- C8 -
1O22
-
?
A:
[114-144]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
------
P
Y
S
S
V
K
K
K
N
R
N
-
E
L
----
V
E
-
E
F
--
M
------
K
Y
F
F
E
S
K
G
W
-----
N
P
G
-------
E
Y
T
----------
F
S
V
Q
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
37.19
29%
128
- C8 -
1XQ8
-
SYUA_HUMAN
A:
[22-73]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
-------
G
S
K
T
K
---
E
G
V
---
V
H
G
-------------
V
A
T
V
A
E
K
T
-----
K
E
-----
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
--
Q
K
T
V
------
E
G
A
G
S
I
A
A
A
-
T
-----
G
F
-
V
K
K
D
Q
------
L
G
K
N
E
E
G
A
P
Q
E
-
G
I
----
L
E
-
D
M
--
P
------
V
D
P
D
N
E
A
Y
E
-----
M
P
S
-------
E
E
G
----------
Y
Q
D
Y
E
P
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
36.91
39%
149
- C8 -
2KKW
-
SYUA_HUMAN
A:
[25-67]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
-------
G
S
K
T
K
---
E
G
V
---
V
H
G
V
--
A
T
V
A
E
K
T
K
E
Q
V
T
N
V
G
G
A
V
-----
V
T
-----
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
--
A
A
T
G
------
F
V
K
K
D
Q
L
G
K
-
N
-----
E
E
-
G
A
P
Q
E
------
G
I
L
E
D
M
P
V
D
P
D
-
N
E
----
A
Y
-
E
M
--
P
------
S
E
E
G
Y
Q
D
Y
E
-----
P
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
36.75
37%
113
- C12 -
4X61
2
ANM5_HUMAN
A:
[440-490]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
E
L
L
G
-----
S
F
-
A
D
N
E
L
S
P
E
C
L
-----
D
G
A
Q
H
F
L
K
-
D
D
G
V
S
I
P
G
E
Y
T
S
F
L
A
P
I
S
S
S
---------
K
L
Y
--
N
E
V
R
A
C
----------
R
E
K
D
-------------------
R
D
P
E
A
Q
F
E
--
M
P
Y
V
V
R
L
H
N
---
F
-
H
-
Q
L
S
--
A
P
Q
P
C
F
T
F
S
H
-
P
N
R
D
P
M
I
D
N
N
R
Y
C
T
L
-
E
F
P
V
E
V
N
T
V
L
H
G
F
A
G
Y
F
E
T
V
L
Y
Q
D
--
I
T
L
----
S
I
R
P
E
T
H
S
P
G
M
F
S
W
-
F
P
I
L
F
P
I
K
-
Q
P
I
--
T
V
R
E
G
Q
T
I
-------
C
V
--
R
F
W
R
C
S
N
S
K
---
K
V
W
Y
E
W
A
V
T
A
P
V
C
S
A
I
H
N
P
T
G
--
R
S
Y
T
I
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
36.29
29%
156
- C8 -
1XQ8
-
SYUA_HUMAN
A:
[12-59]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
V
V
A
A
A
E
K
T
------------------
K
---
Q
G
V
---
A
E
A
A
--
G
K
T
----
K
E
G
V
L
Y
V
G
S
K
T
-----
K
E
-----
G
V
V
H
G
V
A
T
V
A
E
K
T
K
E
Q
V
--
T
N
V
G
------
G
A
V
V
T
G
V
T
A
-
V
-----
A
Q
-
K
T
V
E
G
------
A
G
S
I
A
A
A
T
G
F
V
-
K
K
----
D
Q
-
L
G
--
K
------
N
E
E
G
A
P
Q
E
G
-----
I
L
E
-------
D
M
P
----------
V
D
P
D
N
E
A
Y
E
-----
M
P
-
S
E
E
G
Y
Q
---
D
-----
Y
E
P
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------