@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0797: (2015-12-04 )
MLKFRAIQSKNKSILSREVHAAEFIPYSCYWNSTTLITKQDWLVKFIKLSGFAFETADDEDLVIQNNIRNQMLRSISSPAFGLYFHTIRRKKNIFSDEFASQNFPNFFANHVNLKWREKHATRQSFINDLYITIIRRADTKGVEFLSHLLKKFGHVTSKHAWESDMRATYEDLEETTNRVMTNLRSYSPKILGVKETPNGLFCEIMEFLSRIVNCGFITNTLLPLKTEISRYLPVHRLFFGRKMIQVVTHNESKYAGIVSIKEYGNNTSAGMLDHFLQLPYEFIITQSFQFTNRQMAIAKMQIQQNRMIQSADKAISQIAEISHALDDAMSGRIVFGEHHLTILCIEKSPKSLDNALSFVESELSNCGVYPIREKVNLEPAFWAQVPGNFDYIVRKGTISSLNLAGFVSQHNYPTGNKFNNHWGDAVTVFDTTSGTPFFFNFHIRDVGHTMIIGPTGAGKTVLMNFLCAQAMKFSPRIFFFDKDRGAEIFLRALGGIYTLIEPRTKTNFNPLQLDDTPDNRTFLMEWIKSLISVYNDKFTSEDITRVNDAIEGNFKLRKEDRFLRNLVPFLGLAGSDTLAGAISMWHGNGSHAAIFDNKEDLLDFSKARVFGFEMASLLKDPIALGPVLIYLFHRISISLDGTPSIIVLDEAWALIDNPVFAPKIKDWLKVLRKLNAFVVFATQSVEDASKSAISDTLVQQTATQIFLPNLKATSIYRNVFMLTEREYILIKHTDPSTRFFLVKQGINAVVARIDLKGLDDIVNVLSGRAESVILLHDILKEVGDDPKVWLPIFYQKVKNV
Atome Classification :
(20 SA)
----------------------.........10........20..--------......30........40........50........60.--.......70........80........90........100.......110.......120.......130.......140.......150.....--------..160.......170.......180.......190.......200.......210.......220...-------.------------------------...230.......240.......250.......260.......270.......280.--------......290.......300.......310-----.........320......-.330-------.....-------..340.......350.......360.....---..370.....-------..380......----.--390.......400.......410.......-420.......430..----.....440.----..-....450--.........460...-....-470.-....---...480......-.-490.......500.......510.....-.----.520.-.......530.......--------540.......-----550..-..------------..------.--560---.......-.570...----------------------....580-.......--590----------------..-....-...-------600.....------.-----.610--....----....620...-----....630------........640----.........650---.--..-....--.--.660....--.-..670.-.-.....680---........690--.---.......700.......710.-..-....720........730.......740-----....-....750..-....-.760.......770......---.780.......790.......800------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------M
L
K
F
R
A
I
QSK
N
K
S
I
L
S
REVHA
A
E
--------
F
I
P
Y
S
C
Y
WN
S
T
T
L
I
T
K
Q
D
W
L
V
K
F
I
K
LS
G
F
A
FETADDE
D
L
--
V
I
Q
N
N
I
R
N
Q
M
L
R
S
ISSP
A
F
G
L
Y
F
H
T
I
R
R
KKNIF
S
D
E
FASQN
F
P
N
F
F
A
N
HV
N
L
K
W
R
E
K
HA
T
R
Q
S
F
I
N
D
L
Y
I
T
I
I
RRADTK
G
V
E
F
L
S
H
L
L
K
K
FG
H
V
T
--------
S
K
H
A
W
E
S
D
M
R
A
T
Y
E
D
L
E
E
T
T
N
R
V
M
T
N
L
R
SYS
P
K
I
L
G
VKETPN
G
L
F
C
E
I
M
E
F
L
S
R
I
V
NCGFITNTLL
P
L
-------
K
------------------------
T
E
I
S
R
Y
L
P
V
H
R
L
F
F
G
R
K
M
I
Q
V
V
THNES
K
Y
A
G
I
V
S
I
K
EYGNNT
S
A
G
M
L
D
H
F
L
QL
P
Y
E
F
--------
I
ITQSFQFTNR
Q
M
A
I
A
K
M
Q
I
Q
Q
N
R
M
I
Q
-------
S
A
D
K
A
I
S
Q
I
A
E
I
S
H
A
L
D
D
-AMSG-------
R
I
V
F
G-------EH
H
L
T
I
L
C
IEKSP
K
S
L
D
N
A
L
S
F
V
E
S
E
L
SNC---GVYP
I
R
E
KVN-------LEPA
F
W
AQVPG----N--
F
D
Y
I
V
RKGTISSLN
L
A
G
F
V
S
QHNYPTGNKF-NNHWG
D
A
V
T
V
F
DTTS----G
T
P
F
F
F
N
F
H
----
I
R-DVG
H
T
----
M
I
I
GPTGA
G
K
T
V
L
M
N
-
F
L
C
A
-
Q
A
-M-KFS
P
---
R
I
F
F
F
DKDR
G
A
E
-
I
-
F
L
R
A
LG
G
I
Y
T
LIEPRTKTNFNPLQLDDT-P----D
N
R
-
T
-
F
L
M
E
W
I
K
S
L
I
S
V
YNDKF--------TS
E
D
I
T
R
V
N
D-----AIEGN-
F
K
------------L
R
------
K
--
E
D
----
R
F
L
R
N
L
V
-
P
F
LGLAG----------------------S
D
T
L
A
G
A
-
I
S
M
WHGN--G------------------
S
H
-
A
A
I
F-D
N
K
-------
E
D
L
L
D
F
S
K
------
A
-----
R
V
F
---
G
F
E
M
----
A
S
L
LKDPI
A
L
-----
G
P
V
L
I
Y
-------
L
F
H
R
I
S
I
SL------DGT
P
S
I
I
V
LD-----E--
A
W
-
A
L
ID--N--PVF
A
P
K
I
K
--
D
-
W
L
K
V
L
R
-K-LN
A
F
V
V
F
----
A
TQSVE
D
A
S
K
---
S
---
A
I
S
D
T
L
V
Q
Q
T
A
T
Q
IFLPNL
K
A
-
T
S
-
I
Y
R
N
V
F
-
M
L
TER
E
Y
I
L
I
K
HTDPS
T
R
F
F
------
L
V
K
Q-
G
I
N
A
V
V
A
R
I-DLK
G
-
L
D
D
I
V
N
V
LSGRA
E
S
V
I
L
L
H
D
---
I
L
K
EVGDDPK
V
W
L
P
I
F
Y
Q
K
VKNV-------------------
34
Fugue
81.45
14%
-53
- C2 -
2WP8
1
RRP44_YEAST
J:
[12-977]
VREHYLRSDIPCLSRSCTKCPQ
I
V
V
P
D
A
Q
N
E
L
P
K
F
I
L
S
D
S
P
L
E
L
S
APIGKHYV
V
L
D
T
N
V
V
L
Q
A
I
D
L
L
E
N
P
N
C
F
F
D
V
I
-
V
P
Q
I
V
L
D
E
V
R
N
K
S
Y
--
P
V
Y
T
R
L
R
T
L
C
R
D
S
D
D
H
K
R
F
I
V
F
-------
H
N
E
F
S
E
H
T
F
V
E
N
D
R
N
D
R
A
I
R
K
T
C
Q
W
Y
S
E
H
L
K
P
Y
D
I
---
N
V
V
L
V
T
N
D
E
S
N
I
I
T
K
S
L
V
Q
Y
I
E
L
L
P
N
A
D
DIRDSFTF
P
E
Y
Y
S
T
A
R
V
M
G
G
L
K
N
G
V
L
Y
Q
G
N
I
Q
I
S
E
Y
N
F
L
E
G
S
V
S
L
P
R
F
S
K
P
V
L
I
V
G
Q
K
N
L
N
R
A
F
N
G
D
Q
V
I
V
E
L
L
P
Q
-------
S
EWKAPSSIVLDSEHFDVNDNPDIE
N
T
T
V
I
S
D
K
Q
R
R
L
L
A
K
D
A
M
I
A
Q
R
S
K
K
I
Q
P
T
A
K
V
V
Y
I
Q
R
R
S
W
R
Q
Y
V
G
Q
L
A
P
S
S
V
D
P
Q
S
S
--------
S
-
T
Q
N
V
F
V
I
L
M
D
K
C
L
P
K
V
R
I
R
T
R
R
A
A
E
-------
L
L
D
K
R
I
V
I
S
I
D
S
W
P
T
T
H
K
-
Y
P
L
G
-------
H
F
V
R
D
LGTIESA
Q
A
E
T
E
A
L
L
L
E
H
D
V
E
Y
R
P
F
S
K
K
V
L
E
C
L
P
A
E
G
---
H
D
W
K
A
P
T
K
L
D
-------
D
P
E
A
V
S
K
D
P
L
L
----
T
--
K
R
K
D
L
R
D
K
L
I
C
S
I
D
P
P
G
C
V
D
I
N
D
A
L
H
A
K
K
L
P
N
G
N
W
E
V
G
V
H
I
A
D
V
T
H
FVKP
G
T
A
L
D
A
E
G
A
----
A
R
-
G
T
S
V
Y
----
L
V
D
K
R
I
D
M
L
P
M
L
L
G
T
-
D
L
C
S
-
L
K
-
P
-
Y
V
D
R
---
F
A
F
S
V
I
W
E
L
D
D
S
-
A
-
N
I
V
N
V
N
F
M
K
S
V
I
R
S
R
E
A
F
S
Y
E
Q
A
Q
L
R
I
D
-
D
KTQN
D
E
L
-
T
-
M
G
M
R
A
L
L
K
L
S
V
K
L
K
Q
K
R
LEAGALNL
A
S
P
E
V
K
V
H
M
D
-----
S
E
T
S
D
-
P
N
EV----------
E
I
------
K
--
K
L
----
L
A
T
N
S
L
V
-
E
E
F
M
L
L
A
----------------------
N
I
S
V
A
R
K
-
I
Y
D
A
F
P
Q
--
T
AMLR--------------
R
H
-
A
A
P
P
-
S
T
N
-------
F
E
I
L
N
E
M
L
------
N
-----
T
R
K
---
N
M
S
I
SLES
S
K
A
L
A
D
S
L
D
R
CVDPE
D
P
Y
F
N
T
-------
L
V
R
I
M
S
T
R
C
------
M
M
A
A
Q
Y
F
Y
S
G
-----
A
YS
Y
P
-
D
F
R
H
--
Y
--
G
L
A
V
D
I
Y
T
--
H
-
F
T
S
P
I
R
-
R
-
Y
C
D
V
V
A
H
RQLA
G
A
I
G
Y
E
P
L
S
L
---
T
---
H
R
D
K
N
K
M
D
M
I
C
R
N
I
N
R
K
H
R
N
A
-
Q
F
-
A
G
R
A
S
I
-
E
Y
Y
V
G
Q
V
M
R
N
N
E
S
T
E
T
G
Y
V
I
------
K
V
F
N
N
G
I
V
V
L
V
P
K
F
-
G
V
E
G
-
L
I
R
L
D
N
L
T
E
D
P
N
S
A
A
F
D
E
V
E
YKL
T
F
V
P
T
N
S
D
K
P
R
D
V
Y
V
F
-
D
K
V
E
V
Q
VRSVMDPITSKRKAELLLK
27
Fugue
73.48
16%
-91
- C2 -
4AG6
3
?
A:
[3-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
I
-
N
D
--
G
S
G
I
V
L
G
K
D
R
D
----
G
G
L
V
L
V
D
I
W
----
K
R
-
G
G
D
R
T
NS
N
W
T
I
L
A
K
P
G
A
G
K
S
F
T
A
K
M
L
L
L
R
-
E
Y
M
Q
---
G
S
---
R
V
I
I
I
D
P
E
R
E
Y
K
-
E
M
C
R
K
L
G
G
V
W
I
N
C
--
T
G
G
E
G
K
I
N
P
L
Q
V
R
L
R
-
P
----
Q
S
P
L
A
-
L
H
I
Q
T
L
R
T
F
F
S
L
Y
L
R
D
L
--------
T
D
T
E
K
A
A
L
E
D
-----
A
L
V
E
V
-
Y
K
E
A
GITWDTDPRG
V
P
------
N
--
D
K
WPT
V
K
E
L
Y
E
Y
C
-
V
K
K
A
E
E
N
----------------------
P
E
T
Y
G
R
L
-
S
V
L
L
K
R
A
AE
G
------------------
A
D
-
S
Y
L
W
-
A
G
P
-------
T
A
V
E
A
D
S
D
------
F
-----
I
V
F
D
VH
D
L
Q
N
----
A
E
D
Q
V
K
R
A
Q
Y
-----
F
N
V
L
S
F
-------
A
W
N
I
L
E
R
D
R
------
R
-
E
R
T
V
L
V
V
D
-----
E
--
A
W
M
L
V
D
P
--
Q
T-
P
Q
A
I
A
F
L
R
--
D
-
T
S
K
R
I
R
-
K
-
Y
N
G
S
L
I
V
----
I
S
Q
N
V
I
D
F
L
A
PEV
Q
---
R
Y
G
Q
A
L
L
D
N
P
T
Y
K
L
L
L
A
Q
G
E
K
-
D
L
-
E
A
I
T
T
L
M
N
L
S
E
A
E
H
D
L
L
V
N
A
K
R
G
E
G
L
F
------
V
A
G
T
-
Q
R
I
H
I
K
I
E
A
-
A
P
Y
E
M
Q
Y
---------------------------------------------------------------
28
Fugue
65.89
14%
-81
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
-------
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
-
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
-------
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
AV
I
S
V
R
V
V
E
V
I
P
-------
G
K
T
T
V
G
I
E
I
P
N
----
E
----------
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
------
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
----
G
R
P
I
I
T
D
------
L
A
-
K
M
P
H
L
----
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
-
A
M
L
L
-
S
I
-
L
F
K
S
T
P
SE
A
R
L
I
M
I
D
P
K
M
----
L
-
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-------------
V
-
V
----
T
D
M
-
K
-
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
--------
R
L
M
A
A
M
G
V
R
N
-----
L
A
G
F
N
-
R
K
------------
V
K
------
D
--
A
E
----
E
A
G
T
P
L
T
-
D
--
P
L
F
R
----------------------
R
E
S
P
D
D
E
-
P
P
Q
L
S
T
L
--
P
------------------
T
I
-
V
V
V
V
-
D
E
F
-------
A
D
M
M
M
I
V
G
------
K
-----
K
V
E
---
E
-
L
I
----
A
R
I
A
Q
K
A
R
A
A
-----
G
I
H
L
I
L
-------
A
T
Q
R
P
S
V
D
V
IT
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
VSS
K
I
D
--
S
R
-
T
I
L
D
--
Q
--
G
G
A
E
Q
L
L
G
HG
D
-
M
L
Y
L
P
P
-
G
-
T
G
L
P
I
R
V
----
H
G
A
F
V
S
D
D
E
V
---
H
---
R
V
V
E
A
W
K
L
R
G
A
P
D
-
Y
I
E
D
I
L
A
-
G
------------------------------------------------------------------------------------------------------------------------
31
Fugue
62.36
14%
-45
- C2 -
1TF7
4
KAIC_SYNE7
A:
[14-497]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
Q
A
I
A
K
M
R
T
M
I
E
G
F
D
D
I
S
H
G
G
L
P
I
G
R
S
T
L
V
S
G
T
S
GTG
K
------------------------
T
L
F
S
I
Q
F
L
Y
N
G
I
I
E
F
D
E
P
G
V
F
V
T
F
E
E
T
P
Q
D
I
I
K
N
A
R
S
F
G
W
D
L
A
K
L
V
D
E
G
K
L
F
I
L
D
A
S
PDP
E
G
Q
E
V
V
G
G
F
D
L
S
A
L
I
E
R
I
N
Y
A
I
Q
K
Y
R
A
R
R
V
S
I
D
S
V
T
S
V
F
Q
Q
Y
D
A
S
S
V
V
R
R
E
L
F
R
L
V
A
-
R
L
K
Q
-------
I
G
A
------------
T
T
V
M
T
T
E
R
I
E
E
Y
G
P
I
A
R
Y
G
V
E
E
F
V
S
D
N
---
V
V
I
L
R
N
V
L
E
G
-------
E
R
R
R
R
T
L
E
I
L
K
LRGT
S
--
H
M
K
G
E
Y
P
F
T
I
T
D
H
G
I
N
I
F
P
L
G
A
M
R
L
T
Q
R
S
S
-
N
V
R
V
S
S
G
V
V
R
L
D
E
M
C
----
G
G
------
G
----
F
F
-
K
D
S
I
I
----
L
A
T
G
A
T
G
T
G
K
T
L
L
V
S
-
R
F
V
E
-
N
A
-
C
-
A
N
K
E
---
R
A
I
L
F
A
Y
E
E
S
R
A
-
Q
-
L
L
R
N
A
Y
S
W
G
M
D
F
E
E
M
E
R
Q
N
--
L
L
K
I
V
C
A
-
Y
----
P
E
S
-
A
-
G
L
E
D
H
L
Q
I
I
K
S
E
I
N
D
F
K
--------
P
A
R
I
A
I
D
S
L
S
-----
A
L
A
R
G
-
V
S
------------
N
N
------
A
--
F
R
----
Q
F
V
I
G
V
T
-
G
Y
A
K
Q
E
E
----------------------
I
T
G
L
F
T
N
-
T
S
D
Q
F
M
G
--
A
HSITDSHISTITD
T
I
I
L
L
Q
Y
-
V
E
I
R
-
G
E
M
-------
S
R
A
I
N
V
F
K
------
M
-----
R
G
S
---
W
H
D
K
----
A
I
R
E
F
M
I
S
D
K
-----
G
P
D
I
K
D
-------
S
F
R
N
F
E
R
I
I
------
S
G
S
P
T
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
59.63
13%
-35
- C2 -
3O6X
6
?
A:
[3-728]
----------------------
K
M
R
F
F
A
L
Q
E
L
S
N
--------------------------------------------------------------
R
K
P
L
E
I
T
T
P
S
N
K
L
S
D
Y
Y
A
---------
S
H
V
F
D
R
K
K
M
Q
E
Y
L
P
K
E
A
Y
K
A
V
V
D
A
T
E
K
G
T
P
I
S
R
E
M
A
D
L
I
A
N
G
M
K
S
W
A
K
S
L
N
V
---
T
H
Y
T
H
W
F
Q
P
L
T
--------
K
H
D
G
F
I
E
F
-
G
E
D
G
E
V
I
E
R
F
S
G
K
L
L
T
A
W
D
G
S
S
P
--------------------------
A
F
V
V
D
T
T
L
C
I
-------
P
------------------------
T
I
F
I
E
A
L
-------
D
Y
K
T
P
L
L
K
A
L
A
A
V
D
K
A
A
T
E
V
C
Q
L
F
D
K
N
I
T
--------
R
V
F
T
N
L
--------
G
W
E
Q
E
Y
F
L
V
D
T
S
L
Y
N
A
R
P
--------------------------------
D
L
-
R
L
T
G
-------
R
T
L
M
G
-------
H
---------
S
I
P
P
R
V
T
A
F
M
K
E
L
E
I
E
C
H
K
L
---
G
I
P
V
K
T
R
H
N
E
-------
V
A
P
N
Q
F
E
L
A
P
I
----
F
--
E
N
--
C
N
L
A
N
D
H
N
Q
L
V
M
D
L
M
K
R
I
A
R
K
H
H
F
A
V
-
L
F
H
----
E
K
P
Y
N
G
V
N
----
G
S
G
K
H
N
N
W
S
----
L
C
T
D
T
G
I
N
----
L
F
A
P
G
K
N
P
K
G
N
M
L
F
L
-
T
F
L
V
-
N
V
-
L
-
M
M
V
H
---
K
N
---------
Q
-
D
-
L
L
R
A
S
I
------------------
M
S
A
G
-
N
----
S
H
R
-
L
-
G
A
N
E
A
P
P
A
I
L
S
I
F
L
G
S
Q
--------
L
S
A
T
L
D
E
I
R
N
RTSPF
A
F
T
G
N
R
F
E
------------
F
R
------
A
AG
S
S
----
A
N
C
A
A
A
M
-
I
A
I
N
A
A
M
----------------------
A
N
Q
L
N
E
F
-
K
A
S
V
D
K
D
--
E
------------------
A
I
-
F
R
I
L
---
K
-------
E
N
I
I
A
S
E
L
------
I
-----
R
F
E
---
G
D
G
Y
----
S
E
E
W
K
Q
E
A
A
R
-----
R
G
L
T
N
I
-------
C
H
V
P
E
A
L
M
H
------
Y
M
D
N
Q
S
R
A
V
L
-----
I
--
G
E
-
R
I
F
N
--
E
--
T
E
L
A
C
R
L
E
--
V
-
E
L
E
K
Y
T
-
M
---
K
V
Q
I
E
----
S
R
V
L
G
D
L
A
I
N
---
H
---
I
V
P
I
A
V
S
Y
Q
N
R
L
L
E
N
L
C
R
M
K
E
-
I
F
-
S
E
E
E
Y
E
-
V
M
S
A
D
R
K
E
L
I
K
E
I
S
H
R
V
S
A
I
K
V
L
V
R
D
M
T
E
A
-
R
K
V
A
N
H
K
E
N
-
F
K
E
K
-
A
F
A
Y
E
E
T
V
R
P
Y
L
E
S
I
R
D
H
I
D
---
H
L
E
M
E
I
D
D
E
I
W
P
L
P
K
Y
R
E
L
L
F
T
--------------------
29
Fugue
57.79
12%
-38
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
--------
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
W
M
P
L
V
V
--
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
-
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
-----------
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
-------
G
Q
-------
E
------------------------
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
--
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
--------
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
-------
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
--------------------------------------------------------------
E
Q
E
K
D
-------
E
G
K
R
V
I
D
R
A
T
G
----
D
--
L
E
F
R
-------
N
V
T
F
-------
T
Y
P
G
R
E
V
---------------------
P
A
L
R
N
I
N
L
K
----
I
P
-
A
G
K
T
V
----
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
-
L
I
-----------
T
---
R
--
F
Y
D
I
D
E
G
-
H
-
I
-
L
M
------------------------
D
G
-
H
----
D
L
R
-
E
-
Y
T
L
A
S
L
R
N
Q
V
A
L
V
-------------
S
Q
N
V
H
L
F
N
D
-----
T
V
A
N
N
-
I
A
------------
Y
---------------------------
A
R
T
E
----------------------
E
Y
S
R
E
Q
I
-
E
E
A
A
R
M
A
--
Y
------------------
A
M
-
D
F
I
N
-
K
M
D
-------
N
G
L
D
T
I
I
G
------
E
-----
N
-----
G
V
L
L
----
S
G
G
Q
R
Q
R
I
A
I
-----
A
R
A
L
L
R
------------------------
D
S
P
I
L
I
L
D
-----
E
--
A
--------------------------------------------
T
S
A
L
D
T
E
S
E
---
R
---
A
I
Q
A
A
L
D
E
L
Q
K
N
---------------
R
T
S
L
-
V
I
A
H
R
L
S
T
I
----
E
Q
A
D
E
I
V
------
V
V
E
D
-
G
I
I
V
E
R
G
T
-------------------------
H
S
---
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
------------------------
37
HHSearch
57.00
13%
-77
- C2 -
1E9R
2
?
A:
[35-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
----
A
K
Q
V
T
V
A
G
V
PMPR
D
A
-
E
P
R
H
L
----
L
V
N
G
A
T
G
T
G
K
S
V
L
L
R
-
E
L
A
Y
-
T
G
-
L
-
L
R
G
D
---
R
M
V
I
V
D
P
N
G
D
M
L
-
S
-
K
F
G
R
D
K
D
I
I
L
N
P
Y
D
Q
R
T
K
G
W
S
F
F
N
E
I
R
N
-
D
----
Y
D
W
-
Q
R
Y
A
L
S
V
V
P
R
G
K
T
D
E
A
E
E
W
--------
A
S
Y
G
R
L
L
L
R
E
-----
T
A
K
K
L
-
A
L
------------
I
----------
G
T
----
P
S
M
R
E
L
F
-
H
W
T
T
I
A
T
F
D
D
L
R
G
F
L
EGTLA
E
S
L
F
A
GS
N
E
A
S
K
A
L
T
S
-
A
R
F
V
L
S
---
D
------------------
K
L
-
P
E
H
V
-
T
M
P
-------
D
G
D
F
S
I
R
S
W
L
E
DPN
G
-----
G
N
L
---
F
I
T
W
----
R
E
D
M
--
G
P
A
L
-----
R
P
L
I
S
A
-------
W
V
D
V
V
C
T
S
I
L
S
LPEE
P
K
R
R
L
W
L
F
I
D
-----
E
--
L
A
-
S
L
E
K
--
L
--
A
----
S
L
A
--
D
-
A
L
T
K
G
R
-
K
-
A
G
L
R
V
V
A
----
G
L
Q
S
T
S
Q
L
D
D
---
V
YG
V
K
E
A
Q
T
L
R
A
S
F
R
S
L
V
V
L
G
G
S
R
T
-
D
P
-
K
T
N
E
D
M
-
S
L
S
L
G
E
H
E
V
E
R
D
R
A
L
E
R
V
R
E
------
R
V
V
M
-
P
A
E
I
A
N
L
P
D
-
L
T
A
Y
-
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
---
N
R
Q
P
A
F
V
E
G
T
--------------------------------
35
Fugue
55.96
10%
-35
- C2 -
3DU6
-
?
A:
[1-596]
--------------------------------
M
V
H
Y
Y
R
L
S
L
K
S
R
Q
--------
K
A
P
K
I
V
N
S
K
Y
N
S
I
L
N
I
A
L
K
N
F
R
L
C
K
K
H
K
T
K
K
P
V
Q
I
L
A
L
L
Q
E
I
I
P
K
S
Y
F
G
T
T
T
N
L
K
R
F
Y
K
V
V
E
K
I
L
T
Q
S
S
F
E
C
I
H
L
S
V
L
H
K
C
Y
D
Y
D
A
I
P
W
L
Q
N
V
E
P
N
L
R
P
K
L
L
L
K
H
N
L
F
L
L
D
N
I
V
K
P
I
I
A
F
Y
Y
K
P
I
K
T
L
N
G
H
E
I
K
F
I
--------
R
K
E
E
Y
I
S
F
E
S
K
V
F
H
K
L
K
K
M
K
Y
L
V
E
V
Q
D
E
V
K
P
R
G
V
L
N
I
I
P
K
Q
D
--------------------------------------------------------------
N
F
R
A
I
V
S
I
F
P
D
S
A
R
K
P
F
F
K
L
L
T
S
K
I
Y
K
V
L
E
E
K
Y
K
T
S
G
S
L
Y
T
C
W
S
E
F
T
Q
K
--------------------
T
Q
G
Q
I
Y
G
I
K
V
D
I
R
D
A
Y
G
N
V
-------
K
I
P
V
L
C
K
L
I
Q
S
I
P
----------------------------------------
T
H
L
L
D
S
E
K
K
N
F
I
V
D
H
I
S
N
----------
Q
F
V
A
-------
F
R
R
K
I
Y
K
W
N
H
G
------------------------------
L
L
Q
G
D
P
L
---------------------
S
G
C
L
C
E
L
Y
----
M
A
-
F
M
D
R
L
----
Y
F
--
S
N
L
D
K
D
A
F
I
H
R
-
T
V
----------
D
D
---
Y
F
F
C
S
P
H
P
H
K
V
Y
-
D
-
F
E
L
L
I
K
G
V
Y
Q
V
N
P
T
K
T
R
T
N
L
------
P
T
-
H
----
R
H
P
-
Q
-
D
E
I
P
Y
C
G
K
I
F
N
L
T
T
R
Q
V
--------
R
T
L
Y
K
L
P
P
N
Y
-----
E
I
R
H
K
-
F
K
------------
L
W
------
N
--
F
N
----
N
Q
I
S
D
D
-------
N
P
----------------------
A
R
F
L
Q
K
A
-
M
D
F
P
F
I
C
--
N
------------------
S
F
-
T
K
F
E
F
N
T
V
-------
F
N
--------------------------
D
Q
----
R
T
V
F
A
N
F
Y
D
A
-----
M
I
C
V
A
Y
-------
K
F
D
A
A
M
M
A
L
------
R
T
S
F
--------------------
L
--
V
--
N
D
F
G
F
I
W
L
--
V
-
L
S
S
T
V
R
-
A
-
Y
A
S
R
A
F
K
----
K
I
V
T
Y
K
G
G
K
Y
---
R
---
K
V
T
F
Q
C
L
K
S
I
A
W
R
A
F
L
A
V
L
K
R
R
T
E
-
I
Y
K
G
L
I
-
D
R
I
K
S
R
E
K
L
T
M
K
F
H
D
G
E
V
D
A
------
S
Y
F
---------------------------------------------
C
K
L
P
E
K
F
R
F
V
K
I
N
R
K
A
S
I
-------------------
30
Fugue
51.08
14%
-79
- C2 -
2PJZ
5
?
A:
[1-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
Q
L
K
N
V
G
I
T
L
S
G
K
G
Y
--------
E
R
F
S
L
E
N
I
N
L
-----
E
V
N
G
E
-
K
V
------------
I
I
L
G
P
NGS
G
--
K
T
----
T
L
L
R
A
I
S
-
G
L
L
P
Y
S
G
----------------------
N
I
F
I
N
G
M
E
V
R
K
I
R
N
Y
--
I
------------------
R
Y
-
S
T
N
L
-
P
E
A
YEIGVT
V
N
D
I
V
Y
L
Y
E
------
E
L
K
GLD
R
D
L
---
F
L
E
M
----
L
K
A
L
K
L
G
E
E
I
-----
L
R
R
K
L
Y
KLS
A
G
Q
S
V
L
V
R
T
S
L
A
L
------
A
S
Q
P
E
I
V
G
L
D
-----
E
--
P
F
-
E
N
V
D
--------
A
A
R
R
H
--
V
-
I
S
R
Y
I
K
-
E
-
Y
G
K
E
G
I
L
----
V
T
H
E
L
D
M
L
N
L
--------
Y
K
E
Y
K
A
Y
F
L
V
G
N
R
L
Q
G
P
I
S
V
-
S
E
-
L
L
E
S
S
I
-
V
E
G
E
R
N
D
A
L
L
V
L
D
I
M
D
K
K
V
S
------
I
V
K
G
-
D
L
G
M
K
F
G
A
L
G
S
L
N
R
-
I
Y
G
I
I
------------------------------------------------------------
36
Fugue
45.63
10%
-22
- C2 -
1G6O
1
?
A:
[6-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
-------
A
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
-------
E
I
C
Y
N
-------
G
N
K
V
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
--
H
F
A
R
C
C
A
S
F
K
KKTIDNY
E
N
P
I
L
S
S
N
L
A
N
----
G
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
T
I
S
I
S
I
R
I
P
S
K
T
T
Y
P
H
S
-
F
F
E
E
Q
G
F
Y
N
L
L
D
N
K
E
----
Q
A
I
S
A
I
K
D
G
----
I
A
-
I
G
K
N
V
----
I
V
C
G
G
T
G
S
G
K
T
T
Y
I
K
-
S
I
--M
E
F
-
I
-
P
K
E
E
---
R
I
I
S
I
E
D
T
E
--
E
-
I
-
V
F
K
H
H
K
N
Y
T
Q
L
F
F
G
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
----
P
D
R
-
I
-
I
L
G
E
L
R
S
S
E
A
Y
D
F
Y
N
V
L
--------
C
S
G
H
K
G
T
L
T
T
-----
L
H
A
G
S
-----------------------
S
--
E
E
----
A
F
I
R
L
A
N
M
S
S
S
N
S
A
A
----------------------
R
N
I
K
F
E
S
-
L
I
E
G
F
K
D
--
L
------------------
I
D
M
I
V
H
I
-
N
H
H
-------
K
Q
C
D
E
F
Y
I
------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
38.16
14%
-30
- C2 -
2IUS
-
FTSK_ECOLI
A:
[1114-1217]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
I
V
V
L
V
D
-----
E
--
F
A
-
D
L
M
M
--
T
V
G
K
K
V
E
E
L
I
A
--
R
-
L
A
Q
K
A
R
-
A
-
A
G
I
H
L
V
L
----
A
T
Q
R
P
S
V
D
V
---------
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
-
I
D
S
R
T
--
I
L
-
D
Q
A
G
A
--
E
--
S
L
L
G
M
--
G
D
M
------
L
Y
S
G
-
P
N
S
T
L
P
V
R
V
-----------------------------------------------------------------------
41
HHSearch
37.72
25%
46
- C2 -
3FVQ
-
FBPC_NEIG1
A:
[156-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
L
I
L
L
D
-----
E
--
P
F
-
S
A
L
---
D
--
E
Q
L
R
R
Q
I
R
--
E
D
M
I
A
A
L
R
-
A
-
N
G
K
S
A
V
F
----
V
S
H
D
R
E
E
A
L
Q
---
Y
---
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
-
Y
R
-
Q
P
A
D
L
D
-
A
A
L
F
I
G
E
G
I
V
F
P
A
A
L
N
A
D
G
T
------
A
D
C
R
-
L
G
R
L
P
V
Q
S
G
-
A
P
A
G
-
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
---
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
-------------------
1
PsiBlast_PDB
37.36
29%
1
- C3 -
4ZPJ
8
?
A:
[307-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Y
T
A
Y
N
D
T
P
--------
E
S
Q
E
F
V
E
A
-------------
F
T
------------
A
R
------
H
--
E
G
-----
I
L
P
G
L
V
-
D
Y
A
G
Y
I
G
----------------------
G
R
V
I
A
E
A
-
L
T
A
I
D
G
E
---------------------------
V
-
E
N
K
-------
E
A
L
L
E
A
L
K
------
A
-----
V
E
F
---
T
G
P
A
----
G
N
F
R
F
H
P
E
S
Q
-----
G
P
V
T
T
I
-------
L
L
C
R
V
E
Q
L
D
------
D
G
T
Y
A
N
I
V
V
D
-----
R
--
I
P
-
D
F
D
D
--
L
--
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
35.79
16%
3
- C2 -
2IUT
-
FTSK_PSEAE
A:
[343-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
V
V
V
V
D
-----
E
--
F
A
-
D
M
M
M
--
I
V
G
K
K
V
E
E
L
I
A
--
R
-
I
A
Q
K
A
R
-
A
-
A
G
I
H
L
I
L
----
A
T
Q
R
P
S
V
D
V
---------
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
-
I
D
-
S
R
T
I
L
D
-
Q
G
G
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
------
G
L
P
I
-
R
V
H
G
A
F
V
S
D
-
D
E
V
H
-
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
---
G
-----------------------------------------
26
PsiBlast_CBE
35.64
34%
27
- C3 -
4AG5
3
?
A:
[264-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
L
V
V
D
-----
E
--
A
W
-
M
L
V
D
PQ
T
--
P
Q
A
I
A
F
L
R
--
D
-
T
S
K
R
I
R
-
K
-
Y
N
G
S
L
I
V
----
I
S
Q
N
V
I
D
F
L
A
---
P
---
E
V
Q
R
Y
G
Q
A
L
L
D
N
P
T
Y
K
L
L
L
A
Q
-
G
E
-
K
D
L
E
A
I
-
T
T
L
M
N
L
S
E
A
E
H
D
L
L
V
N
A
K
R
G
------
E
G
L
F
-
V
A
G
T
Q
R
I
H
I
-
K
I
E
A
-
A
P
Y
E
M
Q
Y
----------------------------------------------------------
19
PsiBlast_PDB
35.54
30%
-21
- C3 -
1XP8
1
RECA_DEIRA
A:
[77-148]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
E
I
Y
G
P
E
S
G
G
K
T
T
L
A
L
-
A
I
V
A
-
Q
A
-
Q
-
K
A
G
G
---
T
C
A
F
I
D
A
E
H
A
L
D
P
V
-
Y
A
R
A
L
G
-----------
V
N
T
D
E
L
-
L
V
S
Q
-
P
----
D
N
G
-
E
-
Q
A
L
E
I
M
E
L
L
V
R
S
G
A
I
D
V
--------
V
V
V
D
S
V
A
A
L
T
-----
P
R
A
E
I
-
P
G
------------
L
Q
------
A
--
R
L
----
M
S
Q
A
L
R
K
-
L
T
A
I
L
S
K
----------------------
T
G
T
A
A
I
F
-
I
N
Q
V
G
G
R
--
A
------------------
L
K
-
F
Y
A
S
-
V
R
L
-------
D
V
R
K
I
G
Q
P
------
T
-----
V
A
N
---
T
V
K
I
----
K
T
V
K
N
K
V
A
A
P
-----
F
K
E
V
E
L
-------
A
L
V
Y
G
K
G
F
D
------
Q
L
S
D
L
V
G
L
A
A
-----
D
--
M
D
-
I
I
K
K
--
A
--
G
S
F
Y
S
Y
G
D
--
E
-
R
I
G
Q
G
K
-
E
-
K
T
I
A
Y
I
A
----
E
R
P
E
M
E
Q
E
I
R
---
D
---
R
V
M
A
A
I
R
----------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
35.52
34%
18
- C3 -
4AG5
2
?
B:
[264-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
L
V
V
D
-----
E
--
A
W
-
M
L
V
D
PQ
T
--
P
Q
A
I
A
F
L
R
--
D
-
T
S
K
R
I
R
-
K
-
Y
N
G
S
L
I
V
----
I
S
Q
N
V
I
D
F
L
A
---
P
---
E
V
Q
R
Y
G
Q
A
L
L
D
N
P
T
Y
K
L
L
L
A
Q
-
G
E
-
K
D
L
E
A
I
-
T
T
L
M
N
L
S
E
A
E
H
D
L
L
V
N
A
K
R
G
------
E
G
L
F
-
V
A
G
T
Q
R
I
H
I
-
K
I
E
A
-
A
P
Y
E
M
Q
-----------------------------------------------------------
51
HHSearch
34.98
27%
69
- C2 -
3D31
-
?
A:
[145-193]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
K
I
L
L
L
D
-----
E
--
P
L
-
S
A
L
---
D
--
P
R
T
Q
E
N
A
R
--
E
-
M
L
S
V
L
H
-
K
K
N
K
L
T
V
L
H
----
I
T
H
D
Q
T
E
A
R
I
---
M
---
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
-
F
E
-
K
P
V
E
G
R
-
V
A
S
F
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
Q
------
G
L
L
R
-
I
R
V
G
E
V
V
I
D
-
A
A
G
D
-
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
A
L
S
K
---
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
-------------------
50
HHSearch
34.96
23%
49
- C2 -
2IT1
-
?
A:
[151-199]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
E
V
L
L
L
D
-----
E
--
P
L
-
S
N
L
---
D
--
A
L
L
R
L
E
V
R
--
A
-
E
L
K
R
L
Q
K
E
-
L
G
I
T
T
V
Y
----
V
T
H
D
Q
A
E
A
L
A
---
M
---
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
-
Y
Y
-
K
P
K
Y
K
F
-
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
D
G
------
K
L
V
I
-
T
E
K
S
K
L
P
I
P
-
K
Q
Y
V
-
E
I
V
K
E
T
G
I
T
E
V
I
I
G
F
R
P
H
D
A
---
E
I
V
K
G
E
G
E
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
-------------------
40
HHSearch
34.89
21%
51
- C2 -
1Z47
-
?
A:
[163-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
Q
V
L
L
F
D
-----
E
--
P
F
-
A
A
I
---
D
--
T
Q
I
R
R
E
L
R
--
T
-
F
V
R
Q
V
H
-
D
E
M
G
V
T
S
V
F
----
V
T
H
D
Q
E
E
A
L
E
---
V
---
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
-
Y
E
-
K
P
G
T
L
F
-
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
------
E
V
A
G
-
A
A
L
P
V
D
P
A
V
-
S
E
G
S
-
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
---
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
-------------------