@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0001: (2016-03-11 )
MSEKEIWEKVLEIAQEKLSAVSYSTFLKDTELYTIKDGEAIVLSSIPFNANWLNQQYAEIIQAILFDVVGYEVKPHFITTEELANYSNNETATPKETTKPSTETTEDNHVLGREQFNAHNTFDTFVIGPGNRFPHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHHVLDNNPDAKVIYTSSEKFTNEFIKSIRDNEGEAFRERYRNIDVLLIDDIQFIQNKVQTQEEFFYTFNELHQNNKQIVISSDRPPKEIAQLEDRLRSRFEWGLIVDITPPDYETRMAILQKKIEEEKLDIPPEALNYIANQIQSNIRELEGALTRLLAYSQLLGKPITTELTAEALKDIIQAPKSKKITIQDIQKIVGQYYNVRIEDFSAKKRTKSIAYPRQIAMYLSRELTDFSLPKIGEEFGGRDHTTVIHAHEKISKDLKEDPIFKQEVENLEKEIRNV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140..-------.....150.......160.......170.......180.......190..-.....200.......-210-.-.......220.......---230.......240--..-----------------.---------.....250.......260......--.270.......280.......290.......300.......310...-....320--.......330...-....340.......350.......360-.......370.......380.......390.......400.......410.......420.......430.......440.......450.--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
E
K
E
I
W
E
K
V
L
E
I
A
Q
E
K
L
S
A
V
S
Y
S
T
FLKDT
E
L
Y
T
IKDG
E
A
I
V
L
SSIPFN
A
N
W
L
N
Q
Q
Y
A
E
I
I
Q
A
I
L
F
D
VVGYEVKP
H
F
I
T
T
E
E
L
ANYSNNETATPKETTKPSTETTEDN
H
V
L
G
R
E
QFNAHNTF
D
T
F
V
IGPGNRFPHA
A
S
L
A
V
AEA-------PAKAY
N
P
L
F
I
YGGVGL
G
K
T
H
L
M
H
A
I
G
H
H
VLDNNPD
A
K
V
I
Y
TS
S
E
K
F
T
N
E
F
-
I
K
S
I
RDNE
G
E
A
F
R
E
R
-Y-R-N-I
D
V
L
L
ID
D
I
Q
F
I
Q
N
K
V
Q
---
T
Q
E
E
F
F
Y
T
F
N
E
L---HQ-----------------N---------N
K
Q
I
V
I
SSDR
P
P
K
E
I
A
Q
L
E
D
R
L
R
S
--RFEW
G
L
I
V
DITPP
D
Y
E
T
R
M
A
I
L
Q
K
K
I
E
E
EKLDI
P
P
E
A
L
N
Y
I
A
N
Q
I
Q
S
-
N
I
R
E
L
E
G
--
A
L
T
R
L
L
A
Y
S
Q
L
LG-KP
I
T
T
E
L
T
A
E
A
L
K
D
I
I
QAPKSK
K
I
T
I
Q
-
D
I
Q
K
I
V
G
Q
YY
N
V
R
I
EDFSAKKRTKSIA
Y
P
R
Q
I
A
M
Y
L
S
R
ELTDFSL
P
K
I
G
E
E
FGGRDH
T
T
V
I
H
A
H
E
K
I
S
K
D
L
KEDP
I
F
K
Q
E
V
E
N
L
E
K
E
IRNV--
42
HHSearch
94.38
37%
-79
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[2-321]
-----------------------------------------------------------------------------------------------------------------
D
F
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
K
K
R
--
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
E
L
-
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
-
T
K
-
N
V
R
E
I
E
G
--
K
I
K
L
I
K
L
K
G
F
E
G
L
-
E
--
R
K
E
-------------
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
D
---
26
PsiBlast_CBE
93.23
35%
-80
- C2 -
3R8F
3
DNAA_AQUAE
D:
[4-318]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
KI
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
---
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
31
Fugue
93.06
36%
-84
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[2-324]
-----------------------------------------------------------------------------------------------------------------
D
F
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
K
K
R
G
Y
--
R
V
I
Y
S
S
A
D
D
F
A
Q
-
A
M
V
E
H
L
K
K
G
T
I
N
E
F
R
-
N
M
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
-
K
-
N
V
R
E
I
E
G
--
K
I
K
L
I
K
L
K
G
-----------------
F
E
G
L
E
R
K
E
R
K
E
R
D
K
L
M
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
R
K
--
F
K
H
L
V
G
F
L
E
K
Q
A
F
D
K
IC
5
PsiBlast_PDB
93.01
35%
-83
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[4-318]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
K
I
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
4
PsiBlast_PDB
92.11
35%
-79
- C2 -
3R8F
4
DNAA_AQUAE
A:
[4-318]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
K
I
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
---
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
27
PsiBlast_CBE
91.94
35%
-79
- C2 -
3R8F
4
DNAA_AQUAE
C:
[4-318]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
KI
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
---
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
28
PsiBlast_CBE
91.88
35%
-77
- C2 -
3R8F
4
DNAA_AQUAE
B:
[4-318]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
KI
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
---
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
24
PsiBlast_CBE
90.42
35%
-75
- C2 -
2HCB
3
DNAA_AQUAE
C:
[3-317]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
KI
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
---
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
23
PsiBlast_CBE
90.22
35%
-75
- C2 -
2HCB
2
DNAA_AQUAE
D:
[3-317]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
KI
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
25
PsiBlast_CBE
89.98
35%
-74
- C2 -
2HCB
3
DNAA_AQUAE
B:
[3-317]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
K
I
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
--
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
1
PsiBlast_PDB
89.13
35%
-93
- C2 -
2Z4R
2
DNAA_THEMA
A:
[96-335]
-----------------------------------------------------------------------------------------------------
T
------------
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
-------
P
G
R
-
Y
N
P
L
F
I
Y
G
G
V
G
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
N
E
P
D
L
R
V
M
Y
I
T
S
E
K
F
L
N
D
L
-
V
D
S
M
K
E
G
K
L
N
E
F
R
E
K
-
Y
-
R
-
K
K
V
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
---
V
Q
T
E
L
F
H
T
F
N
E
L
---
H
D
-----------------
S
---------
G
K
Q
I
V
I
C
S
D
R
E
P
Q
K
L
S
E
F
Q
D
R
L
V
S
--
R
F
Q
M
G
L
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
E
E
V
L
N
F
V
A
E
N
V
D
D
-
N
L
R
R
L
R
G
--
A
I
I
K
L
L
V
Y
K
E
T
T
G
-
K
E
V
D
L
K
E
A
I
L
L
L
K
D
F
I
K
P
-------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.87
35%
-93
- C2 -
2Z4R
2
DNAA_THEMA
B:
[96-335]
-----------------------------------------------------------------------------------------------------
T
------------
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
-------
P
G
R
-
Y
N
P
L
F
I
Y
G
G
V
G
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
N
E
P
D
L
R
V
M
Y
I
T
S
E
K
F
L
N
D
L
-
V
D
S
M
K
E
G
K
L
N
E
F
R
E
K
-
Y
-
R
-
K
K
V
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
---
V
Q
T
E
L
F
H
T
F
N
E
L
---
H
D
-----------------
S
---------
G
K
Q
I
V
I
C
S
D
R
E
P
Q
K
L
S
E
F
Q
D
R
L
V
S
--
R
F
Q
M
G
L
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
E
E
V
L
N
F
V
A
E
N
V
D
D
-
N
L
R
R
L
R
G
--
A
I
I
K
L
L
V
Y
K
E
T
T
G
-
K
E
V
D
L
K
E
A
I
L
L
L
K
D
F
I
K
P
-------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.76
35%
-92
- C2 -
2Z4R
2
DNAA_THEMA
C:
[96-335]
-----------------------------------------------------------------------------------------------------
T
------------
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
-------
P
G
R
-
Y
N
P
L
F
I
Y
G
G
V
G
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
N
E
P
D
L
R
V
M
Y
I
T
S
E
K
F
L
N
D
L
-
V
D
S
M
K
E
G
K
L
N
E
F
R
E
K
-
Y
-
R
-
K
K
V
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
---
V
Q
T
E
L
F
H
T
F
N
E
L
---
H
D
-----------------
S
---------
G
K
Q
I
V
I
C
S
D
R
E
P
Q
K
L
S
E
F
Q
D
R
L
V
S
--
R
F
Q
M
G
L
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
E
E
V
L
N
F
V
A
E
N
V
D
D
-
N
L
R
R
L
R
G
--
A
I
I
K
L
L
V
Y
K
E
T
T
G
-
K
E
V
D
L
K
E
A
I
L
L
L
K
D
F
I
K
P
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.75
35%
-76
- C2 -
2HCB
3
DNAA_AQUAE
A:
[3-317]
-------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
-------
L
G
S
L
Y
N
P
I
F
I
Y
G
S
V
G
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
--
K
K
R
G
Y
R
V
I
Y
S
S
A
D
D
F
A
Q
A
M
-
V
E
H
L
K
K
G
T
I
N
E
F
R
N
M
-
Y
-
K
-
S
-
V
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
---
T
Q
I
E
F
F
H
I
F
N
T
L
---
Y
L
-----------------
L
---------
E
K
Q
I
I
L
A
S
D
R
H
P
Q
K
L
D
G
V
S
D
R
L
V
S
--
R
F
E
G
G
I
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
K
E
V
I
D
Y
L
L
E
N
T
K
--
N
V
R
E
I
E
G
K
I
K
L
I
K
L
K
G
F
E
G
L
E
R
-
K
-----------------
E
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
--
R
T
S
E
A
R
K
I
A
M
Y
L
C
R
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
--
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
--
R
K
F
K
H
L
V
G
F
L
E
K
Q
------
2
PsiBlast_PDB
88.15
35%
-91
- C2 -
2Z4S
2
DNAA_THEMA
A:
[96-335]
-----------------------------------------------------------------------------------------------------
T
------------
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
-------
P
G
R
-
Y
N
P
L
F
I
Y
G
G
V
G
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
N
E
P
D
L
R
V
M
Y
I
T
S
E
K
F
L
N
D
L
-
V
D
S
M
K
E
G
K
L
N
E
F
R
E
K
-
Y
-
R
-
K
K
V
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
---
V
Q
T
E
L
F
H
T
F
N
E
L
---
H
D
-----------------
S
---------
G
K
Q
I
V
I
C
S
D
R
E
P
Q
K
L
S
E
F
Q
D
R
L
V
S
--
R
F
Q
M
G
L
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
E
E
V
L
N
F
V
A
E
N
V
D
D
-
N
L
R
R
L
R
G
--
A
I
I
K
L
L
V
Y
K
E
T
T
G
-
K
E
V
D
L
K
E
A
I
L
L
L
K
D
F
I
K
P
-------------------------------------------------------------------------------------------------------
41
HHSearch
87.81
35%
-91
- C2 -
2Z4S
2
DNAA_THEMA
A:
[96-335]
-----------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
-------
P
G
-
R
Y
N
P
L
F
I
Y
G
G
V
G
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
N
E
P
D
L
R
V
M
Y
I
T
S
E
K
F
L
N
D
L
-
V
D
S
M
K
E
G
K
L
N
E
F
R
E
K
-
Y
-
R
K
K
-
V
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
---
V
Q
T
E
L
F
H
T
F
N
E
L
---
H
D
-----------------
S
---------
G
K
Q
I
V
I
C
S
D
R
E
P
Q
K
L
S
E
F
Q
D
R
L
V
S
--
R
F
Q
M
G
L
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
E
E
V
L
N
F
V
A
E
N
V
D
D
-
N
L
R
R
L
R
G
--
A
I
I
K
L
L
V
Y
K
E
T
T
G
-
K
E
V
D
L
K
E
A
I
L
L
L
K
D
F
I
K
P
-------------------------------------------------------------------------------------------------------
45
HHSearch
61.56
22%
-67
- C2 -
1HQC
2
RUVB_THET8
A:
[9-235]
-----------------------------------------------------------------------------------------------------------------------
K
T
L
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
-------
R
K
E
P
L
E
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
-----
V
N
L
R
V
T
S
G
P
A
I
E
K
P
---
G
D
----
L
A
A
I
L
A
N
S
-
L
-
E
-
E
-
G
D
I
L
F
I
D
E
I
H
R
L
S
R
--
Q
---
A
E
E
H
L
Y
P
A
M
E
D
F
---
V
M
D
I
VIGQGPA
A
R
T
I
R
L
E
L
P
---------
R
F
T
L
I
G
A
T
T
R
-
P
---
G
L
I
T
A
P
L
L
S
--
R
F
G
I
--
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
R
G
-
T
M
R
V
A
K
R
--
L
F
R
R
V
R
D
F
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
E
A
L
-------------------------------------------------------------------------------------------------------------
44
HHSearch
60.10
20%
-77
* C2 *
3PFI
1
?
A:
[27-251]
------------------------------------------------------------------------------------------------------------------------
N
F
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
-------
R
N
E
C
L
D
H
I
L
F
S
G
P
A
G
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
A
-----
N
I
K
T
T
A
A
P
M
I
E
K
--------
S
G
D
L
A
A
I
L
T
N
-
L
-
S
-
E
-
G
D
I
L
F
I
D
E
I
H
R
L
S
P
--
A
---
I
E
E
V
L
Y
P
A
M
E
D
Y
---
R
L
------------------A
Q
T
I
K
I
D
L
P
K
F
T
L
I
G
A
T
T
-
R
A
---
G
M
L
S
N
P
L
R
D
--
R
F
G
M
--
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
L
N
K
T
C
E
E
K
A
A
L
E
I
A
K
R
S
R
S
-
T
P
R
I
A
L
R
--
L
L
K
R
V
R
D
F
A
D
V
N
D
E
E
I
I
T
E
K
R
A
N
E
A
L
-------------------------------------------------------------------------------------------------------------
56
HHSearch
59.62
20%
-62
- C2 -
1IY2
1
FTSH_THET8
A:
[33-276]
-------------------------------------------------------------------------------------------------------------------
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
-----
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
-
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
-
K
R
H
-
A
-
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--ND
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-----------------
D
---------
T
A
I
V
V
M
A
A
T
N
R
P
D
---
I
L
D
P
A
L
L
R
PG
R
F
D
R
--
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
--
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
--------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.99
22%
-60
- C2 -
3BOS
13
?
A:
[45-241]
---------------------------------------------------------------------------------------------------------------------------------------------
S
A
A
-------
S
G
D
G
V
Q
A
I
Y
L
W
G
P
V
K
S
G
R
T
H
L
I
H
A
-----------
A
C
A
R
A
N
E
L
E
R
R
S
F
Y
I
-
P
L
G
I
H
A
S
I
S
T
A
L
L
E
G
-
L
-
E
-
Q
-
F
D
L
I
C
I
D
D
V
D
A
V
A
G
H
P
L
---
W
E
E
A
I
F
D
L
Y
N
R
V
A
--
E
Q
-----------------
K
---------
R
G
S
L
I
V
S
A
S
A
S
P
M
E
A
G
F
V
L
P
D
L
V
S
--
R
M
H
W
G
L
T
Y
Q
L
Q
P
M
M
D
D
E
K
L
A
A
L
Q
R
R
A
A
M
R
G
L
Q
L
P
E
D
V
G
R
F
L
L
N
R
M
A
R
-
D
L
R
T
L
F
D
--
V
L
D
R
L
D
K
A
S
M
V
H
Q
-
R
K
L
T
I
P
F
V
K
E
M
L
R
------------------------------------------------------------------------------------------------------------