@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0005: (2016-03-11 )
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
Atome Classification :
(69 SA)
.........10........20........30........40.-........50........60...--.....70...-.....80........90........100.......110.......120------........130.......140....---...150...-.-...160....--.--.--.--170........-------.180.......190.......200.......210......-.220---------.........230.......240.......250.......260.......270.-......--280.......290.......300.......310.......320.......330.......340-........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
T
A
LSDVNNTDNYGAG
Q
I
Q
V
L
E
G
L
E
A
V
R
KRP
G
M
Y
IGSTS-E-R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
GYA--
N
K
I
E
V
V
I
EKD-
N
W
I
K
VTDNGRGI
P
V
D
I
Q
E
KMGR
P
A
V
E
V
I
L
T
V
L
HAGGKFGGG
G
Y
K
VSG-------GLH
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
HRN
E
---
T
I
Y
H
Q
A
Y
K
K-G-VPQ
F
D
L
K
EVG--T--T--D--K--T
G
T
V
I
R
F
K-------ADG
E
I
F
T
E
T
T
VY
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
LNKG
I
Q
I
T
LRDERD-EE-----------NVREDSYHYEG
G
I
K
S
Y
V
E
L
L
NENKEPIHDE
P
I
Y
I
HQSKD
D
I
E
V
E
I
A
I
Q
YNSGY-
A
T
N
L
L
T
--YAN
N
I
H
TYEGGTH
E
D
G
F
K
R
A
L
T
R
V
L
N
SYGL
S
S
K
I
M
K
E
E
K
D
RLSG
E
D
T
REG
M
T
A
I
I
S
I
KHGDP--QFEGQTKTKLG
N
S
E
V
R
Q
V
V
D
K
L
F
S
E
H
F
E
R
F
L
YEN
P
Q
V
A
R
T
V
V
E
K
G
I
M
A
A
R
A
R
V
A
A
K
K
A
R
E
V
T
R
R
KSAL
D
V
A
SLPGKLADCSSKSPE
E
C
E
I
F
L
V
EGDSAGGSTKSGRDSR
T
Q
A
I
LPLR
G
K
I
L
N
V
E
K
A
R
L
D
R
IL
N
N
N
E
I
R
Q
M
I
T
A
F
GTGIGGD
F
D
LAK
A
R
Y
H
K
I
V
I
M
TDADVD
G
A
H
I
R
T
L
L
L
T
F
F
Y
R
F
M
R
P
L
I
EA
G
Y
V
Y
IAQPP
L
Y
K
LTQG
K
Q
K
Y
Y
V
YN
D
R
E
L
D
K
L
K
S
ELNPTPKWS
I
A
RYKGLGEM
N
A
D
Q
L
W
E
TTMNP
E
H
R
A
L
L
Q
V
K
L
E
D
AIE
A
D
Q
T
F
E
M
L
M
G
D
V
V
E
N
R
R
Q
F
I
EDN
A
V
Y
ANLDF
1
PsiBlast_PDB
89.43
51%
-92
- C3 -
4I3H
2
?
A:
[24-647]
--------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
-
G
G
K
P
V
T
T
L
K
K
I
G
--
T
--
A
PK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
---
E
F
H
Y
E
N
G
V
Q
D
F
V
S
Y
L
N
E
D
K
E
-
I
L
T
P
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
L
S
--
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
---------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
G
---
A
Y
A
W
-
D
G
E
L
E
E
L
R
----------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
-----
2
PsiBlast_PDB
86.93
51%
-94
- C3 -
4JUO
4
PARE_STRPN
C:
[47-662]
--------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
-
G
G
K
P
V
T
T
L
K
K
I
G
--
T
--
A
PK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
E
-
I
L
T
P
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
L
S
--
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
HL
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-----------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
---------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
-----
111
Fugue
68.74
52%
-60
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
----------
S
N
S
S
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
68.73
52%
-60
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
----------
S
N
S
S
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.37
51%
-63
- C2 -
4WUD
4
GYRB_ECOLI
A:
[3-375]
------------
S
Y
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.99
52%
-62
- C2 -
1EI1
5
GYRB_ECOLI
A:
[9-375]
------------------
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.78
52%
-67
- C2 -
4PRV
2
GYRB_ECOLI
A:
[16-382]
------------------
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-------------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.49
52%
-71
- C2 -
4ZVI
3
?
A:
[1-361]
------------------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
--------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
67.23
52%
-63
- C2 -
1EI1
6
GYRB_ECOLI
B:
[9-375]
------------------
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.15
51%
-64
- C2 -
4WUC
5
GYRB_ECOLI
A:
[3-375]
------------
S
Y
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.02
51%
-62
- C2 -
4WUB
5
GYRB_ECOLI
A:
[3-375]
------------
S
Y
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.89
48%
-64
- C2 -
3ZKB
3
GYRB_MYCTU
D:
[15-427]
-----------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-
T
Q
STAPH------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.80
51%
-63
- C2 -
4XTJ
5
GYRB_ECOLI
A:
[3-375]
------------
S
Y
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
C
--
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
66.68
48%
-62
- C2 -
3ZKD
3
GYRB_MYCTU
H:
[17-426]
-------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-
T
Q
-----------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
66.41
48%
-71
- C2 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
-----------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
---PH---------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.26
48%
-66
- C2 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
----PH---------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.97
48%
-64
- C2 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
-------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-
T
Q
DE
R
A
A
E
S
T
APH
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.88
48%
-64
- C2 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
-----------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
----------------
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
65.82
48%
-65
- C2 -
3ZKB
4
GYRB_MYCTU
C:
[16-430]
------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
---
Y
E
W
S
Q
V
Y
E
K
-
S
-
E
P
-
L
G
L
K
Q
G
A
--
P
--
T
--
K
--
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
---A
P
H
--------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
T
--
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
65.46
45%
-68
- C2 -
1KIJ
3
?
A:
[7-389]
-----------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
---
K
H
H
R
I
A
F
S
R
-
G
-
E
V
T
E
P
L
R
V
V
G
EA
P
--
R
--
G
--
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
-
G
--------------
K
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
T
--
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.05
44%
-69
- C2 -
1KIJ
3
?
B:
[7-372]
-----------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
---
K
H
H
R
I
A
F
S
R
-
G
-
E
V
T
E
P
L
R
V
V
G
--
E
--
A
--
P
RG
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
L
R
-
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
---
Q
D
-
R
Q
-----------
H
G
K
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
T
--
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.88
44%
-69
- C2 -
1KIJ
3
?
A:
[7-372]
-----------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
---
K
H
H
R
I
A
F
S
R
-
G
-
E
V
T
E
P
L
R
V
V
G
--
E
--
A
--
P
RG
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
L
R
-
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
---
Q
D
-
R
Q
-----------
H
G
K
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
T
--
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.02
99%
-74
- C2 -
4URM
1
?
A:
[25-231]
------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
--------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
60.00
37%
-65
- C2 -
1S16
4
PARE_ECOLI
A:
[4-383]
------------
T
Y
N
A
D
A
I
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
R
-----
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
---
Q
V
Y
N
I
A
F
E
N
-
G
-
E
K
V
Q
D
L
Q
V
V
G
T-
C
G-
K
--
R
--
N
--
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
-
N
--------------
T
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
P
F
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
E
S
--
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
-
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
59.30
99%
-74
- C2 -
4URM
1
?
B:
[25-231]
------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
F
G
-------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
58.52
38%
-59
- C2 -
1S16
4
PARE_ECOLI
A:
[4-383]
------------
T
Y
N
A
D
A
I
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
R
-
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
---
Q
V
Y
N
I
A
F
E
N
-
G
-
E
K
V
Q
D
L
Q
V
V
G
--
T
--
C
--
G
--
K
R
N
T
G
T
S
V
H
F
W
-------
P
D
-
E
T
F
F
D
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
---------------
N
N
T
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
P
F
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
-
E
-
G
G
E
L
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
-
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
57.90
38%
-60
- C2 -
1S16
4
PARE_ECOLI
B:
[4-383]
------------
T
Y
N
A
D
A
I
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
R
-
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
---
Q
V
Y
N
I
A
F
E
N
-
G
-
E
K
V
Q
D
L
Q
V
V
G
--
T
--
C
--
G
--
K
RN
T
G
T
S
V
H
F
W
-------
P
D
-
E
T
F
F
D
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
---------------
N
N
T
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
P
F
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
-
E
-
G
G
E
L
L
T
ES
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
-
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
57.10
99%
-73
- C2 -
4URO
1
GYRB_STAAU
B:
[26-231]
-------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.04
99%
-75
- C2 -
4URM
2
?
C:
[25-231]
------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.96
99%
-74
- C2 -
4URO
1
GYRB_STAAU
A:
[26-231]
-------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
--------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
55.88
99%
-76
- C2 -
4URO
2
GYRB_STAAU
D:
[25-230]
------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
------
P
A
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.68
89%
-69
- C2 -
3U2D
3
GYRB_STAAU
A:
[2-195]
-------------
Y
G
A
G
Q
I
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
55.65
99%
-72
- C2 -
4URO
1
GYRB_STAAU
C:
[25-230]
------------------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
----------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
55.52
89%
-69
- C2 -
3TTZ
3
GYRB_STAAU
B:
[8-195]
-------------------
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
---
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
55.35
88%
-74
- C2 -
4P8O
1
GYRB_STAAR
B:
[3-186]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
55.03
99%
-73
- C2 -
4URM
1
?
D:
[26-231]
-------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
L
H
A
G
-----------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.01
89%
-69
- C2 -
3TTZ
3
GYRB_STAAU
A:
[2-195]
-------------
Y
G
A
G
Q
I
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.52
89%
-68
- C2 -
3U2K
4
GYRB_STAAU
A:
[2-195]
-------------
Y
G
A
G
Q
I
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.25
88%
-73
- C2 -
4P8O
1
GYRB_STAAR
A:
[3-186]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
54.21
89%
-69
- C2 -
3U2K
3
GYRB_STAAU
B:
[8-195]
-------------------
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
---
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
54.02
55%
-77
- C2 -
4MB9
2
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------
G
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.68
88%
-73
- C2 -
3G7B
1
GYRB_STAAU
B:
[1-184]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
53.61
56%
-72
- C2 -
1AJ6
1
GYRB_ECOLI
A:
[11-216]
--------------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
H
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.59
88%
-68
- C2 -
3G7B
1
GYRB_STAAU
A:
[1-184]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
53.29
89%
-70
- C2 -
3U2D
4
GYRB_STAAU
B:
[8-195]
-------------------
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
--
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.14
88%
-73
- C2 -
3G75
1
GYRB_STAAU
B:
[1-184]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
52.92
58%
-75
- C2 -
4HYP
2
GYRB_ECOLI
D:
[2-205]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
52.52
55%
-78
- C2 -
5BOD
1
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------------
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
52.51
55%
-78
- C2 -
4MOT
1
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Fugue
52.39
56%
-62
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-219]
-------
S
N
S
S
D
S
S
S
I
K
---
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
--HC
K
E
I
I
V
T
I
H
A
-D
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-------NSYKVSG
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
-G
K
I
H
R
Q
I
Y
E
--
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
---E-
K
--
T
G
T
M
V
R
F
W
P
SLETFT-------
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-
K
R
-
D
-------------
G
K
E
D
H
F
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.39
88%
-67
- C2 -
3G75
1
GYRB_STAAU
A:
[1-184]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
------------------------------
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
---
T
I
Y
H
Q
A
Y
K
K
-
G
-
V
P
Q
F
D
L
K
E
V
G
--
T
--
T
--
D
--
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
-
E
E
-----------
N
V
R
E
D
S
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
52.27
55%
-76
- C2 -
4MBC
1
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
52.26
55%
-77
- C2 -
4EM7
1
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
52.25
58%
-76
- C2 -
4HYP
2
GYRB_ECOLI
C:
[2-205]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
51.83
55%
-75
- C2 -
4LPB
1
?
A:
[17-225]
-------------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
--
D
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
-
A
M
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
---
A
V
Y
K
Q
R
F
E
N
G
G
-
K
P
V
T
T
L
K
K
I
G
--
T
--
A
LK
S
--
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
-
D
E
-----------
A
I
E
---
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
50.99
58%
-75
- C2 -
4HYP
2
GYRB_ECOLI
B:
[2-205]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.67
66%
-71
- C2 -
4HXW
2
?
A:
[1-207]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
--------------------------
V
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
G
---
K
V
Y
Y
Q
E
Y
R
R
-
G
-
A
V
V
D
D
L
K
V
I
E
--
E
--
T
--
D
--
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
E
G
Q
E
-----------
D
K
K
E
--
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
50.64
60%
-71
- C2 -
4URN
1
?
C:
[19-224]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
--
N
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
---------------------------
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
---
N
I
Y
H
Q
S
F
K
N
-
G
G
S
P
S
S
G
L
V
K
K
G
--
K
--
T
--
K
--
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
-
G
K
-----------
E
-
R
Q
E
H
Y
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
50.53
58%
-74
- C2 -
4BAE
2
GYRB_MYCSM
B:
[4-204]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
--
T
R
V
D
V
K
I
H
A
D
-
G
S
V
E
V
R
D
D
G
R
G
I
P
V
E
M
H
-
A
T
G
M
P
T
I
D
V
V
M
T
Q
L
-------------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
---
Y
E
W
F
Q
Y
Y
D
R
-
S
-
V
P
G
-
K
L
K
Q
G
G
--
E
--
T
--
K
--
E
--
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
-
E
T
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
D
-
G
--------------
K
H
R
V
F
H
Y
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
50.33
60%
-75
- C2 -
4URN
1
?
A:
[17-223]
---------------------
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
--
N
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
--------------------------
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
---
N
I
Y
H
Q
S
F
K
N
-
G
G
S
P
S
S
G
L
V
K
K
G
--
K
--
T
--
K
--
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
-
G
K
-----------
E
-
R
Q
E
H
Y
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
50.23
66%
-68
- C2 -
4KSG
2
?
A:
[1-207]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
G
---
K
V
Y
Y
Q
E
Y
R
R
-
G
-
A
V
V
D
D
L
K
V
I
E
--
E
--
T
--
D
--
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
E
G
Q
E
-----------
D
K
K
E
--
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
50.21
58%
-69
- C2 -
4KFG
3
GYRB_ECOLI
A:
[2-206]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
-----------
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
50.00
58%
-67
- C2 -
4KFG
3
GYRB_ECOLI
B:
[2-205]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
------
G
V
S
A
A
E
V
I
M
T
V
L
-------
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
49.91
66%
-69
- C2 -
4K4O
2
?
A:
[1-207]
-----------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
G
---
K
V
Y
Y
Q
E
Y
R
R
-
G
-
A
V
V
D
D
L
K
V
I
E
--
E
--
T
--
D
--
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
E
G
Q
E
-----------
D
K
K
E
--
Y
H
Y
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
49.85
56%
-71
- C2 -
4DUH
1
GYRB_ECOLI
B:
[12-217]
--------------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
49.81
58%
-75
- C2 -
4HYP
2
GYRB_ECOLI
A:
[2-205]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
49.08
56%
-65
- C2 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
-----------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
---
K
I
H
R
Q
I
Y
E
H
-
G
-
V
P
Q
A
P
L
A
V
T
G
--
E
--
T
--
E
--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
-
G
--------------
K
E
D
H
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
47.71
60%
-64
- C2 -
4URN
2
?
B:
[32-223]
------------------------------------
G
S
T
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
--
N
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
-------------------------
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
---
N
I
Y
H
Q
S
F
K
N
-
G
G
S
P
S
S
G
L
V
K
K
G
--
K
--
T
--
K
--
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
-
G
K
-----------
E
-
R
Q
E
H
Y
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
46.74
47%
-72
* C2 *
3FV5
1
PARE_ECOLI
A:
[1-201]
-----------------------
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
-----
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
---
Q
V
Y
N
I
A
F
E
N
-
G
-
E
K
V
Q
D
L
Q
V
V
G
--
T
C
G
K
--
R
--
N
--
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
-
N
--------------
T
E
Q
R
W
C
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------