@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0007: (2016-03-11 )
MGGYITMETLNSINIPKRKEDSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEMTDSILIGPGLGVDFKGNNAITFLLQNIQPHQNLIVDGDAITIFSKLKPQLPTCRVIFTPHLKEWERLSGIPIEEQTYERNREAVDRLGATVVLKKHGTEIFFKDEDFKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENLAKDMYVVPPSRLINEIPYAMKQLES
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80.....------...90....---....100.......110.......120........130.......140.-.-...-..150.......160......---.170......-.180-......--..190....-...200..-.....210.......220.......230-..-.....240.......250...--....260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGG
Y
I
T
M
E
TLNSINIPKRKEDSHKGDY
G
K
I
L
L
I
GGSANLG
G
A
I
M
L
A
A
R
A
C
VFSGS
G
L
I
T
V
A
THPT
N
H
S
A
L
H
SRCP
E
A
M
V
I
DIN
D
T
K
------
M
L
T
K
M
I
E
MT---D
S
I
L
IGPGL
G
V
DFKGN
N
A
I
T
F
L
L
Q
NI-QPHQ
N
L
I
VDG
D
A
I
T
I
F
S
KLKPQ-L-P
T
C
-
R
V
I
FTP
H
L
K
E
W
E
R
LSGIPI
E
E
---
Q
T
Y
E
R
N
R
E
A
V
-
D
RL--G
A
T
V
V
L
--KKHG
T
E
I
F
F
-KDE
D
F
K
L
T
-IGSPAMATGGM
G
D
T
L
A
G
M
I
T
S
F
V
G
Q
F
D
N
-
L
K
-
E
A
V
M
S
A
T
Y
T
H
S
F
I
G
E
N
L
AK
D
M
--
Y
VV
P
P
S
R
L
I
N
EI
P
Y
A
M
K
Q
LES
1
PsiBlast_PDB
98.63
45%
-116
- C2 -
2R3B
7
NNRD_ENTFA
A:
[22-291]
---
Y
L
S
K
D
I
L
E
E
V
-
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
V
------
L
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
-
L
-
T
Y
P
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
Q
---
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
--
G
S
T
I
V
L
--
K
S
H
R
T
T
I
F
H
-
A
G
E
P
F
Q
N
T
-
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
--
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
---
2
PsiBlast_PDB
98.35
45%
-119
- C2 -
2R3E
2
NNRD_ENTFA
A:
[22-291]
---
Y
L
S
K
D
I
L
E
E
V
-
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
V
------
L
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
-
L
-
T
Y
P
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
Q
---
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
--
G
S
T
I
V
L
--
K
S
H
R
T
T
I
F
H
-
A
G
E
P
F
Q
N
T
-
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
--
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
---
29
HHSearch
96.54
45%
-107
* C2 *
2R3B
7
NNRD_ENTFA
A:
[20-294]
-
M
R
Y
L
S
K
D
-
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
V
V
G
F
E
E
T
V
------
L
L
T
N
V
V
E
Q
A
---
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L
T
-
Y
P
E
-
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
S
H
L
P
I
E
Q
---
Q
T
L
A
N
N
Q
R
Q
Q
-
A
K
L
--
G
S
T
I
V
L
--
K
S
H
R
T
T
I
F
H
-
A
G
E
P
F
Q
N
T
-
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
F
K
P
-
T
I
-
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
--
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
3
PsiBlast_PDB
92.62
43%
-101
- C2 -
3BGK
2
?
A:
[35-308]
---
M
I
I
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
A
F
D
M
V
E
K
D
------
R
L
S
E
Q
I
T
A
A
---
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
T
T
F
D
V
V
W
Q
A
I
-
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
-
A
-
I
W
P
T
K
-
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
S
G
L
T
I
P
E
---
Q
I
E
A
A
T
Q
T
A
L
-
A
H
F
--
P
K
E
T
I
L
VA
K
S
H
Q
T
K
I
Y
Q
-
G
Q
K
I
G
H
I
Q
-
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
H
T
-
D
R
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
A
--
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
M
K
E
---
30
HHSearch
90.93
44%
-104
- C2 -
3BGK
2
?
A:
[37-311]
----
I
D
D
L
-
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
A
F
D
M
V
E
K
D
------
R
L
S
E
Q
I
T
A
A
---
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
-
Q
T
T
F
D
V
V
W
Q
A
I
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
-
A
I
W
-
P
T
K
-
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
S
G
L
T
I
P
E
----
Q
I
E
A
A
T
Q
T
A
L
A
H
F
PK
E
T
I
L
V
A
--
K
S
H
Q
T
K
I
Y
Q
-
G
Q
K
I
G
H
I
Q
-
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
F
H
T
D
R
F
-
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
A
--
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
M
K
E
M
S
E
15
PsiBlast_PDB
81.50
29%
-101
- C2 -
3RTG
4
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
11
PsiBlast_PDB
81.50
29%
-102
- C2 -
3RTA
1
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
17
PsiBlast_PDB
80.93
29%
-101
- C2 -
3RRB
2
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
20
PsiBlast_PDB
80.86
29%
-102
- C2 -
3RRJ
-
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
14
PsiBlast_PDB
80.86
29%
-103
- C2 -
3RTE
3
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
5
PsiBlast_PDB
80.81
29%
-103
- C2 -
3RS9
2
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
DV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
16
PsiBlast_PDB
80.69
29%
-102
- C2 -
3RU3
2
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
6
PsiBlast_PDB
80.62
29%
-102
- C2 -
3RSF
-
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
8
PsiBlast_PDB
80.58
29%
-102
- C2 -
3RSS
-
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
4
PsiBlast_PDB
80.57
29%
-101
- C2 -
3RS8
4
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
19
PsiBlast_PDB
80.50
29%
-102
- C2 -
3RRF
2
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
DV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
12
PsiBlast_PDB
80.37
29%
-102
- C2 -
3RTC
3
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
18
PsiBlast_PDB
80.27
29%
-104
- C2 -
3RRE
2
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
10
PsiBlast_PDB
80.26
29%
-101
- C2 -
3RT9
3
NNR_THEMA
A:
[223-501]
----
I
T
R
E
M
V
R
S
L
-
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
GFFSLQ
N
L
Q
E
C
L
E
L
S
KDV
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
-
E
--
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
-
E
-
R
K
S
-
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
VK-
Y
N
Y
E
L
A
E
E
F
A
-
K
E
N
--
D
C
V
L
V
L
--
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
-
P
L
-
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
--
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
-
32
HHSearch
80.10
30%
-85
- C2 -
3RPZ
3
NNRD_BACSU
A:
[5-279]
N
V
P
F
W
T
E
E
-
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
A
-----
A
D
A
Q
L
E
E
T
Y
---
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
----
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
--
P
K
---
R
E
G
-
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
H
SA
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
W
K
R
F
E
-
28
PsiBlast_CBE
74.81
33%
-91
- C2 -
3RPH
4
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------
27
PsiBlast_CBE
74.69
33%
-91
- C2 -
3RPZ
3
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------
25
PsiBlast_CBE
73.51
33%
-89
- C2 -
3RQ6
3
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------
23
PsiBlast_CBE
73.38
33%
-90
- C2 -
3RQH
3
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------
22
PsiBlast_CBE
73.32
33%
-90
- C2 -
3RQQ
2
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------
26
PsiBlast_CBE
72.95
33%
-90
- C2 -
3RQ2
3
NNRD_BACSU
A:
[18-251]
--------------
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
------
A
A
D
A
Q
L
E
E
T
Y--
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
D
-
C
P
---
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
K
R
E
-
G
-
P
----
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
-
A
Q
L
--
Q
T
V
I
V
L
--
K
G
N
Q
T
V
I
A
F
-
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
-
P
K
-
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
-----------------------------