@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0012: (2016-03-11 )
MYKLLISIKEVKIIAIVKNMGVAYVFSKIQPKATIIATITLVFVALALYLVPGLGLIFALFATIPGIVLWNKSIQSFGVSALITVIITTVLGNTFVLSAIILVLIASLIIGQLLKERTSKERMLYVTTVAMSLISLIAFMLLQTFGRIPPSASIVKPFKQTLHEAITMSGADANMTQILEEGFRQATVQLPGFIIIITFLIVLINLIVTFPVLRKFKIATPVFKPLFAWQMSGILLWIYIIVIICLLFTGQPSVFQSILLNFQLVLSLVMYIQGLSVIHFFGKAKGLPNAVTILLLIIGTILTPTTHIVGLLGVIDLSLNLKRIMKNNSKK
Atome Classification :
(16 SA)
-------------------------------------.........10........20........30....------...-----.40.....-.----..50.....-.----..60..-------.-.------..-------------..70-.........80...-----.....90-..--.-----..----...100.......110.......120.......-130.......140....----..--------------.150.......160..-----.....170--.......180.......-190.....--------------..200---.....------....210.....---------------..220..-..--.....230----.....----------..240---------........250-.......-260-.....--..270.----.-----.....280......------.290.------------......300--.......310.......320.......330--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------
M
Y
K
L
L
I
S
I
K
E
V
K
I
I
A
I
VKNM
G
V
A
Y
V
F
SKIQPK
A
T
I
------
I
A
T
-----
I
T
L
V
F
V
A
L
-
A
----
L
Y
LVP
G
L
G
L
-
I
----
F
A
L
F
A
T-------I-P------
G
I
-------------
V
L
W
--
N
K
S
I
Q
S
F
G
V
S
A
L
I
T
-----
V
I
I
T
T
V
L-G
N
--
T
-----
F
V
----
L
S
A
I
I
L
V
L
I
A
S
L
I
I
G
Q
L
L
K
E
RTSKE
R
M
L
Y
V
T
T
V
-
A
M
S
L
I
S
L
I
A
F
M
L
L
Q
T
FG----RI--------------PP
S
A
S
I
V
K
P
F
K
Q
T
L
H
E
-----
A
I
TMSGAD--
A
N
M
T
Q
I
L
E
E
G
F
R
Q
A
T
V
Q-LP
G
F
I
I
I
I
--------------
T
F
L
-----
I
V
L
I
N
------
L
I
V
T
F
P
V
L
R
K
FK---------------IAT--
P
V
-
F
K
--
P
L
F
A
W
Q
M
S
----
G
I
L
L
W
----------
I
Y
I
I
----------
V
I
I
C
L
LFTG
Q
P
-
S
V
F
Q
S
I
L
-
L
N
F
-
Q
L
V
L
S
--
L
V
M
Y
I
Q
----
G
-----
L
S
V
I
H
F
F
G
KAKGL
P
------
N
A
V
T
I
------------
L
L
L
I
I
G
T
IL--T
P
T
T
H
I
V
G
L
L
G
V
I
DL
S
L
N
L
K
R
I
M
KNNSKK---------
10
Fugue
90.97
17%
-163
* C6 *
4U9O
1
NQRA_VIBCH
A:
[14-332]
-----------------------------------PI
A
G
T
P
S
Q
V
I
S
D
G
K
A
I
K
K
V
A
L
L
G
E
E
Y
V
G
M
R
P
T
M
H
V
R
V
------
G
D
E
-----
V
K
K
A
Q
I
L
F
-
E
----
D
K
K
N
P
G
V
K
F
-
T
----
S
P
V
S
G
K
-------
V
-
V
------
E
I
-------------
N
R
G
--
A
K
R
V
-------
L
Q
S
-----
V
V
I
E
V
A
G
-
D
D
--
Q
-----
V
T
----
F
D
K
F
E
A
N
Q
L
A
S
L
------
N
R
D
A
I
K
T
Q
L
V
E
S
---------
G
L
W
T
A
F
R
T
R
P
F
S
----
K
V
--------------
P
A
I
D
S
---
T
S
E
A
I
F
V
T
-----
A
M
D
T
N
P
L
A
--
A
E
P
T
V
V
I
N
E
Q
S
E
A
F
V
A
G
-
L
D
V
L
S
A
L
T
--------------
T
G
K
-----
V
Y
V
C
K
------
K
G
T
S
L
P
R
S
Q
Q
P
N
---------------
V
E
E
--
H
V
-
F
D
--
G
P
H
P
D
H
V
A
----
W
S
I
N
Y
----------
Q
D
V
I
----------
A
V
G
Q
L
F
L
T
G
E
L
-
Y
T
Q
R
V
V
S
-
L
A
G
-
P
V
V
N
K
P
R
L
V
R
T
V
M
----
G
-----
A
S
L
E
Q
L
V
D
S
-
E
I
M
P
------
G
E
V
R
I
------------
I
S
---
G
S
V
L
SG
T
K
A
T
G
P
H
A
Y
L
G
R
Y
H
L
Q
V
S
V
L
R
------
E
G
---------
18
Fugue
82.53
17%
-170
- C3 -
4OYF
1
?
A:
[9-416]
EYPV
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
GY
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
------
V
G
V
-----
K
I
V
V
Y
Y
L
L
-
T
----
S
A
F
A
V
T
L
G
I
-
I
----
M
A
R
L
F
N
-------
P
G
A
------
G
I
-------------
H
L
A
--
V
G
G
Q
L
V
H
I
L
L
D
I
V
P
-----
T
N
P
F
G
A
L
-
A
N
--
G
-----
Q
V
----
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
----
Q
Y
--------------
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
-----
G
V
H
V
V
G
E
L
--
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
-
V
Y
F
V
L
L
K
I
Y
GID
P
I
S
F
I
K
H
A
K
D
A
M
L
-----
T
A
F
V
T
RSSSGT
L
P
V
T
M
R
V
A
K
E
M
G
---------------
I
S
E
--
G
I
-
Y
S
--
F
T
L
P
L
G
A
T
INM
D
G
T
A
L
Y
----------
Q
G
V
C
----------
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
-
I
V
L
-
T
A
V
L
A
--
S
I
G
T
A
G
VPG
A
G
-----
A
I
M
L
A
M
V
L
H
S
V
G
L
P
LTD
P
N
V
A
A
A
Y
A
------------
M
I
L
G
I
D
A
I
L
--
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
---------------
19
Fugue
78.92
13%
-185
- C4 -
1K2Y
2
ALGC_PSEAE
X:
[5-463]
----KAPTLPASIFRAYDIRGVVGDTLTAETAYWIGR
A
I
G
S
E
S
L
A
R
G
E
P
C
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
VDCGCQ
V
S
D
-----
V
G
M
V
P
T
P
V
-
L
----
Y
Y
A
A
N
V
L
E
G
-
K
----
S
G
V
M
L
T
GAHNPPD
Y
-
N
------
G
F
-------------
K
I
V
VA
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
-----
R
I
E
K
N
D
L
-
A
S
--
G
-----------
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
M
K
V
V
V
D
C
-
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
CSVI
P
L
YCEVDGNFPNHHPD
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
ENADL
G
L
A
F
D
G
D
G
--
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
-
L
L
M
L
F
A
K
D
--------------
V
V
S
RNPGA
D
I
I
F
D
------
V
K
C
T
R
R
L
I
A
L
I
S
GYGGRPVMWKTGHSL
I
K
K
--
K
M
-
K
E
TG
A
L
L
A
G
E
M
S
----
G
H
V
F
F
KERWFGFDDG
I
Y
S
A
----------
A
R
L
L
E
I
L
S
Q
D
Q
-
R
D
S
E
H
V
F
-
S
A
F
P
S
D
I
S
T
--
P
E
I
N
I
T
----
V
TEDSK
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
------
E
G
N
I
T
TLDGVRVDYPKG
W
G
L
V
R
A
S
N
T
--
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
VDSSLPVPF
12
Fugue
72.78
14%
-168
- C6 -
4QPP
3
ANM6_HUMAN
A:
[48-376]
-------------------------------YYEC
Y
S
D
V
S
V
H
E
E
M
I
A
D
R
V
R
T
D
A
Y
R
L
G
I
L
R
N
W
A
A
L
R
G
K
-
T
V
------
L
D
V
GAGTG
I
L
S
I
F
C
A
Q
-
A
GAR
R
V
Y
A
V
E
A
S
A
I
-
W
----
Q
Q
A
R
E
V
-------
V
-
R
F
N
GLED
R
V
-------------
H
V
L
--
P
G
P
V
E
T
V
E
L
P
E
Q
V
D
-----
A
I
V
S
E
W
M
-
G
Y
--
G
-----
L
L
HESM
L
S
S
V
L
H
A
R
T
K
W
L
K
E
G
G
L
L
L
P
A
S
A
E
L
F
I
V
P
I
S
D
Q
-
M
L
E
W
R
L
G
F
W
S
Q
V
K
Q
H
Y
G
----
V
D
--------------
M
S
C
L
E
G
F
A
T
R
C
L
M
G
H
S
-----
E
I
V
V
Q
G
L
S
--
G
E
D
V
L
A
R
P
Q
R
F
A
Q
L
E
L
S
-
R
A
G
------------------------------
L
E
------
Q
E
L
E
A
G
V
G
G
R
F
R
---------------
C
S
C
--
Y
G
-
S
A
--
P
M
H
---------
G
F
A
I
W
----------
F
Q
V
T
F
P
GGESE
K
P
L
V
L
S
T
S
P
F
H
P
A
T
-
H
W
K
Q
A
L
L
Y
L
N
E
-
P
V
Q
V
E
--
Q
D
T
D
V
S
----
G
-------
E
I
T
L
L
P
S
R
D
N
P
R
------
R
L
R
V
L
------------
L
R
Y
K
V
G
D
Q
E
--
E
K
T
K
D
F
A
---------------
M
E
D
-------------
13
Fugue
63.39
15%
-94
- C7 -
1RP3
-
?
A:
[0-234]
---------------------------------------------------------
H
M
K
N
P
Y
S
N
Q
I
E
R
E
E
L
------
I
L
K
-----
Y
L
P
L
V
K
A
I
-
A
----
T
N
I
K
K
H
L
P
E
-------------------------------------------
D
V
D
--
I
R
D
L
I
S
Y
G
V
I
G
L
I
K
-----
A
V
D
N
L
S
T
-
E
N
--
P
-----
K
R
----
A
E
A
Y
I
K
L
R
I
K
G
A
I
Y
D
Y
L
R
----
S
L
D
F
G
S
R
Q
V
R
E
-
K
E
R
R
I
K
E
V
V
E
K
L
K
E
K
L
G
----
R
E
--------------
P
T
D
E
E
V
A
K
E
L
G
I
S
-
T
E
-----
E
L
F
K
T
L
D
K
--
I
N
F
S
Y
I
L
S
L
E
E
V
F
R
D
F
A
-
R
D
Y
-----------------------------------------
S
E
L
I
P
S
S
T
N
---------------
V
E
E
--
E
V
-
I
K
--
R
E
L
T
E
K
V
K
----
E
A
V
S
------------------------------
K
L
P
E
R
E
-
K
L
V
I
Q
L
I
-
F
Y
E
-
E
L
P
A
K
--
E
V
A
K
I
L
----
E
-----
T
S
---------------------------------------------------
V
S
R
V
S
Q
L
K
A
K
A
L
E
R
L
R
E
M
L
S
N
------------
16
Fugue
51.23
12%
-99
- C5 -
2QMC
1
?
B:
[1-186]
-----------------------------------------------------------
A
T
H
Y
S
V
A
D
R
W
G
N
A
------
V
S
V
-----
T
Y
T
I
N
A
S
Y
G
S
----
A
A
S
I
D
G
A
G
F
-
L
L
N
NE
M
D
D
F
S
I
-------
K
-
P
------
G
N
PNLYG
L
V
G
G
DANA
I
E
A
--
N
K
R
P
L
S
S
M
S
P
T
I
V
L
K
NNKV
F
L
V
V
G
S
P
-
G
G
--
S
-----
R
I
----
I
T
T
V
L
Q
V
I
S
N
V
I
D
Y
N
M
N
I
S
E
A
V
S
A
P
R
F
H
M
Q
W
L
P
-
D
E
L
R
I
E
K
F
G
M
P
A
D
V
K
D
N
----
L
T
--------------
K
M
G
Y
Q
I
V
T
K
P
V
M
G
D
V
N
-----
A
I
Q
V
L
P
K
T
--
K
G
S
V
F
Y
G
S
T
D
P
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
HHSearch
50.80
15%
-101
- C7 -
3RLB
5
?
A:
[17-112]
--------------------------------------------------------------
N
V
R
L
L
T
E
I
A
F
------
M
A
A
-----
L
A
F
I
I
S
-
L
-
I
----
P
N
-
T
V
Y
-
G
W
-
I
----
I
V
E
I
A
C
-------
I
-
P
------
I
L
-------------
L
L
S
--
L
R
R
G
L
T
A
G
L
V
G
G
L
I
-----
W
G
I
L
S
M
I
T
G
H
AY
I
LS
L
S
Q
A
F
----
L
E
Y
L
V
A
P
V
S
L
G
I
-
A
G
L
F
R
Q
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
HHSearch
49.60
13%
-130
- C7 -
3P5N
1
RIBU_STAAH
A:
[11-118]
--------------------------------------------------------------
Q
N
K
R
L
I
T
I
S
M
------
L
S
A
-----
I
A
F
V
L
T
-
F
-
I
----
K
F
P
I
P
F
L
P
P
Y
L
----
T
L
D
F
S
D
-------
V
-
P
------
S
L
-------------
L
A
T
--
F
T
F
G
P
V
A
G
I
I
V
A
L
V
-----
K
N
L
L
N
Y
L
F
S
M
GD
P
-----
V
G
----
P
F
A
N
F
L
A
G
A
S
F
L
L
T
A
Y
A
I
Y
K
N
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
40.47
15%
76
* C7 *
1IRQ
-
?
A:
[24-71]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
G
D
K
T
V
R
V
R
A
D
L
H
H
-----
I
I
K
I
E
T
A
K
N
G
G
N
V
K
E
V
M
D
Q
A
L
E
E
Y
I
R
K
Y
L
P
D
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
37.65
10%
156
- C7 -
1JB0
3
PSAJ_THEEB
J:
[6-35]
-----------------------------------------------------------
T
Y
L
S
T
A
P
V
L
A
A
I
W
------
M
T
I
-----
T
A
G
I
L
I
-
E
-
F
----
N
R
F
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
36.03
13%
83
- C7 -
3L1L
-
ADIC_ECO57
A:
[295-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
Q
T
A
K
A
A
A
---------------
D
D
G
LF
P
P
I
F
A
--
R
V
N
K
A
G
T
P
----
V
A
G
L
I
----------
I
--------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
34.92
10%
249
- C7 -
1L4A
-
CPLX_DORPE
E:
[49-76]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
R
K
E
K
H
R
-----
K
M
E
E
E
R
E
E
--
M
R
Q
T
I
R
D
K
Y
G
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
25.87
17%
438
- C8 -
2XET
2
CAF1A_YERPE
A:
[29-46]
------------------------------------------------
S
S
S
G
I
V
G
D
N
S
G
V
Y
L
T
G
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
25.12
17%
364
* C8 *
3L48
1
?
A:
[33-50]
-----------------------------------------------
G
R
E
L
G
M
V
A
D
E
G
L
A
W
L
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
13.90
27%
1141
- C1 -
2KXA
-
?
A:
[15-24]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
M
I
D
G
W
Y
G
S
-------------------
5
HHSearch
2.18
13%
1611
- C2 -
3U85
-
KMT2A_HUMAN
B:
[1-9]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
W
R
F
P
----
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------