@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0018: (2016-03-11 )
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKKTIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320........330.....--..--340.......350...-.....360.......370...---------..---------..380.......390.......400.....-..410.......420.......430.......440.......450....-...460------..-..-------..--.----470..-.......-480.......490.......500.......510-....-.....520.......530.......540.......550.......560.......570..-.....580.......590.......600......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
W
L
K
Q
L
Q
S
L
H
T
K
L
V
I
V
Y
V
L
L
I
I
I
G
M
Q
I
I
G
L
Y
FTNN
L
E
K
E
L
L
D
N
F
K
K
N
I
T
Q
Y
A
K
Q
L
E
I
S
I
E
K
V
YDEKGSV
N
A
Q
K
D
I
Q
N
L
L
S
E
Y
A
N
R
Q
EIG
E
I
R
F
IDKD
Q
I
I
I
A
TTKQS
N
R
S
L
I
NQKAN
D
S
S
V
Q
K
A
L
SLGQSND
H
L
I
L
K
DYGGGK
D
R
V
W
V
Y
NIP
V
K
V
DK
K
V
I
G
N
I
Y
I
E
S
K
I
N
D
V
Y
N
Q
LNNI
N
Q
I
F
I
V
G
T
A
I
S
L
L
I
T
V
I
L
G
F
F
I
A
R
T
I
TK
P
I
T
D
MRNQ
T
V
E
MSRGN
Y
T
Q
R
V
K
I
Y
GNDE
I
G
E
L
A
L
A
F
N
N
L
S
K
R
V
Q
E
AQAN
T
E
S
E
K
R
R
L
D
S
V
I
T
H
MSD
G
I
I
ATDRRG
R
I
R
I
V
N
D
M
A
L
K
M
LGM
A
K
E
D
I
I
G
Y
Y
M
L
S
V
LSLEDEF
K
L
-
E
E
I
QENND
S
F
L
L
D
LNEE--E
G
--
L
I
A
R
V
N
F
S
T
I
V
Q
-ETG-F
V
T
G
Y
I
A
V
L
H
DV
T
E
Q
Q
Q
V
E
R
E
---------
R
R
---------
E
F
V
A
N
V
S
H
E
LRT
P
L
T
S
M
N
S
Y
I
E
A
L
E
EGAWK-
D
E
E
L
A
P
Q
F
L
S
V
T
R
E
E
T
E
R
M
I
R
L
V
N
D
L
L
Q
L
S
KMDN
E
S
D
Q
I
N
K
E
I
I
D
F
N
M
F
-
I
N
K
I
I
N
------
R
H
-EM-------SA--K----D--
T
T
-
F
I
R
DIPK-K
T
I
F
TEF
D
P
D
K
M
T
Q
V
F
D
N
V
I
T
N
A
M
KYSRGD
K
---
R
V
E
F
-
H
VKQNPLY
N
R
M
T
I
R
I
KDNGIGI
P
I
N
K
V
D
K
I
F
D
R
F
Y
R
V
D
K
A
R
T
RKMGGTGL
G
L
A
I
S
K
E
I
V
E
-AHNG
R
I
W
A
NSVEGQG
T
S
I
F
I
T
L
P
C
E
VIEDGDWDE
88
Fugue
82.94
42%
-65
- C4 -
4I5S
-
?
A:
[37-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
-
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
--
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
-
E
S
G
-
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
-
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
-----
L
D
V
E
L
T
N
F
T
A
F
-
M
N
Y
I
L
D
------
R
F
-
D
Q
-------
I
Q
SQ
Q
----
S
--
T
E
-
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
V
T
I
-
T
M
Q
T
T
D
--
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-----------
1
PsiBlast_PDB
81.58
44%
-62
- C4 -
4I5S
-
?
A:
[54-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
-
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
YD
E
F
--
I
T
L
R
I
R
F
A
L
N
R
R
-
E
S
G
-
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
--
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
-
M
N
Y
I
L
D
------
R
F
D
Q
I
-------
Q
S
--
Q
----
Q
--
S
T
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
V
T
I
-
T
M
Q
T
T
D
--
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-----------
3
PsiBlast_PDB
78.44
49%
-66
- C5 -
4U7O
1
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
---------
R
K
---------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
-
F
N
Y
V
L
D
------
R
F
-
D
M
I
L
KKDDN
P
A
--
K
----
Y
--
Y
T
-
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
T
C
-
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------
2
PsiBlast_PDB
72.66
49%
-76
- C5 -
4U7N
-
?
A:
[39-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
-
F
N
Y
V
L
D
------
R
F
-
D
M
I
L
K
K
DDN---------
Y
--
Y
T
-
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
T
C
-
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------
21
PsiBlast_CBE
70.82
49%
-64
- C5 -
4U7O
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
-
F
N
Y
V
L
D
------
R
F
-
D
M
I
L
K
K
DDN
P
A
--
K
----
Y
--
Y
T
-
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
V
T
C
-
R
L
L
E
T
--
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------
72
HHSearch
67.17
53%
-79
* C5 *
3SL2
2
A:
[3-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
-
M
S
L
I
I
D
------
R
F
-
E
M
-------
T
K
--
E
Q-------
E
-
F
I
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
V
T
F
-
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
--------
9
PsiBlast_PDB
66.85
36%
-52
- C5 -
4JAV
6
?
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
L
---------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
23
PsiBlast_CBE
65.57
36%
-55
- C5 -
4JAV
6
?
B:
[5-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
R
L
---------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
6
PsiBlast_PDB
65.51
53%
-67
- C5 -
3SL2
2
A:
[8-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
M
S
L
I
I
D
------
R
F
-
E
M
-------
T
K
E-
Q
--------
E
-
F
I
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
V
T
F
-
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
--------
67
HHSearch
65.07
37%
-80
- C- -
2C2A
2
?
A:
[18-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
--
N
--
V
N
-
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
-
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
-------
8
PsiBlast_PDB
64.15
36%
-49
- C5 -
3DGE
3
?
A:
[14-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
10
PsiBlast_PDB
63.43
36%
-51
- C5 -
4JAS
2
?
A:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
7
PsiBlast_PDB
63.18
36%
-59
- C5 -
2C2A
2
?
A:
[1-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
V
T
E
S
K
E
L
E
R
L
---------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
11
PsiBlast_PDB
63.14
36%
-55
- C5 -
4JAU
1
?
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
---------
K
R
I
D
R
M
K
T
---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
S
H
N
V
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
24
PsiBlast_CBE
62.95
36%
-47
- C5 -
3DGE
2
?
B:
[14-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
IDRMKT---
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
-
V
E
S
A
V
N
------
A
I
-
K
E
-------
F
A
--
S
SHNV
N
--
V
L
-
F
E
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-----------
65
HHSearch
59.19
24%
-70
- C4 -
3A0R
1
?
A:
[9-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
E
N
K
E
P
V
F
L
N
F
Y
K
F
--
G
E
--
R
Y
F
N
I
R
F
S
P
F
R
N
-
A
K
T
Q
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
E
R
K
R
R
E
R
L
S
I
L
G
---------
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
D
D
--
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
E
F
N
L
N
E
L
-
I
R
E
V
Y
V
------
L
F
-
E
E
-------
K
I
--
R
K
M
--
N
--
I
D
-
F
C
F
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
I
K
I
-
T
S
E
D
--
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
E
-
N
G
V
V
F
I
F
E
I
P
K
T
P
E
K
------
4
PsiBlast_PDB
57.78
96%
-112
- C6 -
4MN5
1
WALK_STAAU
A:
[15-121]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
D
S
V
I
T
H
M
S
D
G
I
I
A
T
D
R
R
G
R
I
R
I
V
N
D
M
A
L
K
M
L
G
M
A
K
E
D
I
I
G
Y
Y
M
L
S
V
L
S
L
E
D
E
F
K
L
-
E
E
I
Q
E
N
N
D
S
F
L
L
D
L
------
G
--
L
I
A
R
V
N
F
S
T
I
V
Q
-
E
T
G
-
F
V
T
G
Y
I
A
V
L
H
D
V
T
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.92
27%
-40
- C5 -
4BIU
-
CPXA_ECOLI
A:
[70-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
S
---------
Q
Q
---------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
L
-----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
-
W
S
E
V
L
D
------
N
A
-
A
F
-------
E
A
--
E
----
Q
M
G
K
S
-
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
V
G
F
-
A
V
D
K
D
----
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
----------
20
PsiBlast_PDB
56.45
24%
-58
- C4 -
3A0R
1
?
A:
[11-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
E
N
K
E
P
V
F
L
N
F
Y
K
F
--
G
E
--
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
-
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
E
---------
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
-
H
L
D
-
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
--------
E
R
-
V
L
E
F
T
E
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
-
K
I
-------
R
K
--
M
----
N
--
I
D
-
F
C
F
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
I
K
---
I
T
S
E
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
------
T
T
------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
E
N
G
V
V
F
I
F
---------------
22
PsiBlast_CBE
56.03
100%
-134
- C6 -
4MN6
1
WALK_STAAU
B:
[4-106]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
I
T
H
M
S
D
G
I
I
A
T
D
R
R
G
R
I
R
I
V
N
D
M
A
L
K
M
L
G
M
A
K
E
D
I
I
G
Y
Y
M
L
S
V
L
S
L
E
D
E
F
K
L
-
E
E
I
------
F
L
L
D
L
------
G
--
L
I
A
R
V
N
F
S
T
I
V
Q
-
E
T
G
-
F
V
T
G
Y
I
A
V
L
H
D
V
T
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------