@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0022: (2016-03-11 )
MKALLLKTSVWLVLLFSVMGLWQVSNAAEQYTPIKAHVVTTIDKATTDKQQVTPTKEAAHQFGEEAATNVSASAQGTADEINNKVTSNAFSNKPSTAVSTKVNETHDVDTQQASTQKPTQSATFTLSNAKTASLSPRMFAANVPQTTTHKILHTNDIHGRLAEEKGRVIGMAKLKTIKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEFDFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRPEGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQLKKRITVIDGHSHTVLQNGQIYNNDALAQTGTALANIGKVTFNYRNGEVSNIKPSLINVKDVENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAMEAYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFEHSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDMNKPSGKRINAIQILNKETGKFENIDLKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANIAKYDTTEPQRMLLGKPAVSEQPAKGQQGSKGSESGKDVQPIGDDKAMNPAKQPATGKVVLLPTHRGTVSSGTEGSGRTLEGATVSSKSGNQLVRMSVPKGSAHEKQLPKTGTNQSSSPAAMFVLVAGIGLIATVRRRKAS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-........160------.-------....--------....-------170.----...----...180------....--------.....190.......200.......210.......220.......230.......240-.........-250--.----.---.------.------.--..260.......270.......280..-.....290........300-.........--310........320.---------......330--.----.------......340....-----...350--.----........360..-----------------.-------------....370---......---...380-.--.---.....390--.....-..400..---..-------...410------........420.....----..430---------------..------------.---....440.......450.......460........470----.......480.......490.---......500.......510.......520.......530.......540.......550.......560.......570...--....--580.........590.......600.......----610-..---.----.--.....620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
A
L
L
L
K
T
S
V
W
L
V
L
L
F
S
V
M
G
L
W
QVSN
A
A
EQYTP
I
K
A
H
V
V
T
TIDKATTDKQQVT
P
T
K
E
A
A
H
Q
F
G
E
E
A
ATNVSASAQG
T
A
D
E
INNKVTSNAFSNKPST
A
V
S
TKVNETHDVDTQQASTQKPTQ
S
A
T
F
T
LSNAKTASLSP
R
M
F
AANVPQTT
T
H
K
I
--
L
HTNDIH
G
R
--------
L
-------
A
E
EK--------
G
R
V
I
-------
G
M
A
K
----
L
K
T
----
I
K
EQ--------EKP
D
--------
L
M
L
DAGDAFQGLPLSNQS
K
G
E
E
M
A
K
A
M
N
AVGY
D
A
M
A
VGNHEFDF
G
Y
D
Q
L
K
K
L
E
G
M
L---DFPMLSTNV-YKD--G----K---R------A------F--KPS
T
I
V
TKNG
I
R
Y
G
I
I
G
V
TTPETKTKT-RPEGIK-GVEFR
D
P
L
Q
S
---
V
T
A
E
M
M
R
I
Y
--
K
-DVD
T
F
V
V
I
S
HLGI---------DPST
Q
E
TW---
R
----
G
------
D
Y
L
V
K
Q
L
SQNPQL-----
K
K
R
I
----
T
----
V
IDGHS
H
T
V
LQN
G
-----------------
Q
-------------IYNND-----ALAQ
T
G
---
T
A
L
A
N
I
-
G
--
K
---
V
T
F
N
YRNG--EVSNI-KPS
L
I
N
V
---
K
D
-------VENVT-------P
N
K
A
L
A
E
Q
I
N
Q
A
D
Q
T
F----RAQ
T
A
---------------
E
V
------------
I
---
I
PN
N
T
I
DFKGERDDVRTRETNL
G
N
A
I
-
A
D
A
M
E
A
YGVKN----FSKKT
D
F
A
V
TNGG
G
I
R
A
SIAK---GK
V
T
R
Y
D
L
I
S
VLPFG
N
T
I
A
Q
I
D
VKGS
D
V
W
T
A
F
E
HSLGAPTTQKDG
K
T
V
L
T
ANG
G
L
L
H
ISD
S
I
R
V
Y
Y
DMNKPSG
K
R
I
N
A
I
Q
I
L--NKET--G--KFENI
D
L
K
R
V
Y
H
V
T
MNDFTASGGDGYSMF----G---GP---R----E--EGI
S
L
D
Q
V
L
A
S
Y
L
K
TANIAKYDTT
E
P
Q
R
MLLGKPAVSEQPAKGQQGSKGSESGKDVQPIGDDKAMNPAKQPAT
G
K
V
V
L
L
PTHRGTVSSGTEGSG
R
T
LE
G
A
T
VSSKSG
N
Q
L
V
R
M
SVPKGS
A
H
E
KQLPKTGTNQSSSP
A
A
M
F
V
L
V
A
G
I
G
L
I
A
T
V
R
R
RKAS
25
HHSearch
94.39
32%
-50
- C2 -
2Z1A
4
?
A:
[28-534]
--------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
T
L
--
V
H
T
N
D
T
H
A
H
--------
L
-------
E
P
V
E
L
T
L
SG
E
K
-
T
P
V
G
-------
G
V
A
R
----
R
V
A
----
L
F
D
R
V
W
A
R
----
A
K
N
P
--------
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
---
R
F
K
V
V
S
A
N
V
-
D
A
S
--
R
EPRL
K
---
G
------
L
------
F
--
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
I
S
-
N
P
G
--
P
-
T
V
A
F
L
D
P
Y
E
S
---
A
Q
K
A
V
Y
E
L
L
A
-
K
-
G
V
N
K
I
V
V
L
S
H
L
G
Y
---------
G
E
D
L
------------------------
K
L
A
R
R
--
L
-----
V
G
V
Q
----
V
----
I
V
G
G
H
S
H
T
L
L
G
S
F
PHKELSPAGPY
P
-----
T
V
V
K
N
P--------
E
G
K
D
V
-----
L
V
V
Q
A
W
---
E
W
G
K
V
V
-
G
--
L
---
L
E
V
T
F
D
A
K
G-
E
L
L
A
Y
-
K
G
E
A
L
L
M
---
T
P
--------
E
A
A
P
-------
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
----
M
A
L
M
Q
---------------
Q
V
------------
I
----
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
R
R
E
S
N
L
G
N
L
I
-
T
D
G
M
L
W
K
T
R
N
-------
A
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
K
---
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
---------
N
T
A
G
R
F
L
Q
V
S
G
-
L
R
Y
A
F
D
L
S
R
P
A
G
S
R
V
V
R
V
E
V
K
--
T
E
----
K
--
G
Y
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
----
K
---
E
A
---
Q
GYRV
D
--
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
--
E
A
G
L
E
G
R
I
E
V
L
N
E
P
---------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.66
27%
-53
- C2 -
3IVD
4
?
A:
[9-485]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
PW
I
-------
A
D
G
K
--------
R
D
I
G
-------
G
W
A
N
----
I
T
T
----
L
V
K
Q
--------
E
K
A
K
N
KA
T
----
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
L
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
---
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
--
S
----
S
---
K
------
S
------
F
WD
K
P
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
-
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
---
L
Q
R
Y
I
D
E
L
K
--
G
-
K
V
D
L
T
V
A
L
I
H
E
G
V
----------
P
A
R
Q
S
S
M
---
G
----
G
------
T
D
V
R
R
A
L
D
K
D
I
Q
T
-----
A
S
Q
V
KGLD
I
----
L
I
T
G
H
A
H
V
G
T
P
E
P
-----------------
I
-------------
K
V
G
N
T
-----
L
I
L
S
T
D
---
S
G
G
I
D
V
-
G
--
K
---
L
V
L
D
Y
K
E
---------
K
P
H
N
F
T
V
---
K
N
-------
F
E
L
K
T
I
Y
ADEWK
P
D
----
Q
Q
T
K
Q
V
I
D
G
W
----
N
K
K
L
D
---------------
E
V
------------
V
QQT
V
A
Q
S
P
V
E
L
K
----
R
A
Y
G
E
S
A
S
L
G
N
L
A
-
A
D
A
L
L
A
A
A
G
K
N
--------
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
A
---
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
--
G
A
-----------
S
L
S
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
G
Q
R
V
I
T
L
T
L
N
--
G
K
P
----------
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
TE--
G
---
K
A
---
R
----
N
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.58
31%
-44
- C2 -
2Z1A
4
?
A:
[29-521]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
L
T
L
--
V
H
T
N
D
T
H
A
H
--------
L
E
P
V
E
L
T
L
S
G
E
K
--------
T
P
V
G
-------
G
V
A
R
R
V
A
L
F
D
R
----
V
W
A
R
--------
A
K
N
P
--------
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
---
R
F
K
V
V
S
A
N
V
---
D
--
A
----
S
---
R
EPRLKG
L
------
F
--
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
I
S
-
N
P
G
--
P
-
T
V
A
F
L
D
P
Y
E
S
---
A
Q
K
A
V
Y
E
L
L
A
-
K
-
G
V
N
K
I
V
V
L
S
H
L
G
Y
---------------------------------------
G
E
D
L
K
L
-----
A
R
R
L
----
V
GVQ
V
I
V
G
G
H
S
H
T
L
L
G
S
---------------------------------
F
P
H
K
-----
E
L
S
P
A
G
PY
P
T
V
V
K
N
P
E
G
--
K
D
V
L
V
V
Q
A
W
E
W
G
--
K
V
V
G
L
-
L
E
V
T
F
D
A
---
K
G
-------
E
L
L
A
Y
-------
K
G
E
A
L
L
M
T
P
E
A
A
P
E
D
F
----
F
A
K
E
A
---------------
L
L
A
Y
A
Q
PV
M
A
L
M
Q
Q
V
---
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
R
R
E
S
N
L
G
N
L
I
-
T
D
G
M
L
W
---
K
T
----
R
N
A
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
K
---
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
----
S
Q
W
E
-----
N
T
A
G
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
A
G
S
R
V
V
R
V
E
V
----
K
T
E
--
K
--
G
Y
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
AQ
G
---
Y
R
---
V
----
D
--
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
89.23
28%
-42
- C2 -
1HP1
7
USHA_ECOLI
A:
[4-501]
-----------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
Y
K
I
T
V
--
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
--------
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
---
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
P
D
I
I
I
A
A
T
H
M
G
H
---------
Y
D
N
G
E
H
G
S
NAP
G
----
D
------
V
E
M
A
R
A
L
P
A
---------
G
S
L
A
----
M
----
I
V
G
G
H
S
Q
D
P
V
C
M
A
AENKKQVDYVPG
T
P
C
K
P
D
-------------
Q
Q
N
G
I
-----
W
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
KKKRVLY
T
P
E
I
A
-------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
----
K
A
Q
L
E
---------------
V
K
------------
I
----
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
-
L
A
A
Q
M
D
R
T
----------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
----------
D
S
G
A
Y
P
Q
F
A
N
-
V
S
F
V
A
K
-----
D
G
K
L
N
D
L
K
I
K
------------
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
---
N
K
PGY
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
--------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.98
28%
-50
- C2 -
4H1Y
6
5NTD_HUMAN
P:
[23-507]
-------------------------------------------------------------------------------------------------------------------------------------------------
P
W
E
L
T
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
DASRCMG
G
V
A
R
----
L
F
T
KVQQ
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
S
A
S
--
G
----
P
---
L
------
A
SQISGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
---------------
M
------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYPF
I
V
T
S
D
DGRKV
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
YL
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
D
--------------
S
S
I
P
-------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
----
D
D
Y
S
T
---------------
Q
E
----------------
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
CT
S
C
R
V
--
P
--
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
88.91
28%
-52
- C2 -
4H2I
5
5NTD_HUMAN
A:
[6-485]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
DASRCMG
G
V
A
R
----
L
F
T
K
V
Q
Q
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
K
A
K
--
G
----
P
---
L
------
A
SQISGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
---------------
M
------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYP
F
I
V
T
S
D
D
G
R
K
V
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
Y
L
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
D
--------------
S
S
I
P
-------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
----
D
D
Y
S
T
---------------
Q
E
----------------
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
--
C
T
K
C
R
V
P
--
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.79
28%
-33
- C2 -
1HP1
7
USHA_ECOLI
A:
[3-510]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
NLK
K
K
-------
R
V
L
Y
T
-------
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
----------------
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
88.61
28%
-51
- C2 -
4H2F
4
5NTD_HUMAN
A:
[23-507]
-------------------------------------------------------------------------------------------------------------------------------------------------
P
W
E
L
T
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
DASR
C
M
G
G
V
A
R
----
L
F
T
K
V
Q
Q
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
K
A
K
--
G
----
P
---
L
------
A
SQISGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
---------------
M
------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYPF
I
V
T
S
D
DG
R
K
V
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
Y
L
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
D
S
---
S
I
-------
P
E
D
P
S
-------
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
----
T
Q
E
L
G
---------------
K
T
------------
I
---
V
Y
-----
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
--
C
T
A
C
--
A
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
88.50
28%
-53
- C2 -
4H2B
5
5NTD_HUMAN
A:
[29-508]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
DASR
C
M
G
G
V
A
R
----
L
F
T
K
V
Q
Q
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
S
A
S
--
G
----
P
---
L
------
A
S
Q
I
SGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
M
---------------------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYP
F
I
V
T
S
D
DG
R
K
V
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
Y
L
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
D
S
---
S
I
-------
P
E
D
P
S
-------
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
----
T
Q
E
L
G
---------------
K
T
------------
I
---
V
Y
-----
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
C
T
S
C
R
V
--
P
--
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.38
28%
-49
- C2 -
4H2G
5
5NTD_HUMAN
A:
[23-507]
-------------------------------------------------------------------------------------------------------------------------------------------------
P
W
E
L
T
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
DASRCMG
G
V
A
R
----
L
F
T
K
V
Q
Q
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
K
A
K
--
G
----
P
---
L
------
A
S
Q
I
SGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
---------------
M
------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYPF
I
V
T
S
D
DG
R
K
V
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
Y
L
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
D
S
---
S
I
-------
P
E
D
P
S
-------
I
K
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
----
T
Q
E
L
G
---------------
K
T
------------
I
---
V
Y
-----
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RND
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
--
C
T
A
C
--
A
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
88.08
26%
-50
- C2 -
3IVE
5
?
A:
[4-501]
-------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
V
T
I
--
I
Y
T
N
D
L
H
A
H
--------
V
-------
E
P
Y
K
V
PWIADGK
R
D
I
G
-------
G
W
A
N
----
I
T
T
----
L
V
K
Q
E
K
A
K
----
N
K
A
T
--------
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
L
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
---
K
F
P
I
V
Q
G
N
I
-
F
Y
Q
--
N
----
S
SKS
F
------
W
------
D
--
K
P
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
-
G
I
E
A
R
D
E
I
K
W
---
L
Q
R
Y
I
D
E
L
K
--
G
-
K
V
D
L
T
V
A
L
I
H
E
G
V
---------
P
A
R
Q
S
S
M
-----D
V
R
R
A
------
L
D
K
D
I
Q
T
A
S
Q
--
V
-----
K
G
L
D
----
I
----
L
I
T
G
H
A
H
V
G
T
P
E
P
-----------------
I
-------------
K
V
G
N
T
-----
L
I
L
S
T
D
---
S
G
G
I
D
V
-
G
--
K
---
L
V
L
D
Y
K
E
K
PH
N
F
T
V
K
-
N
F
E
L
K
T
I
---
Y
--------
A
D
E
W
K
-------
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
K
L
----
D
E
V
V
Q
---------------
Q
T
------------
V
----
A
Q
S
P
V
E
L
K
----
R
A
Y
G
E
S
A
S
L
G
N
L
A
-
A
D
A
L
L
A
A
A
G
--------
K
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
A
---
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
-------------
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
G
Q
R
V
I
T
L
T
L
N
------------
G
K
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
----
T
---
E
G
---
K
A
R
N
I
T
--
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
T
I
--
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
---------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.82
27%
-33
- C2 -
1OI8
4
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
C
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
T
-------
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.29
27%
-34
- C2 -
1OID
1
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGCN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
T
-------
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
DNK-
C
---
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.25
28%
-49
- C2 -
4H1S
4
5NTD_HUMAN
A:
[6-485]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
L
H
T
N
D
V
H
S
R
--------
L
EQT----
S
E
D
S
--------
S
K
C
V
NASRCMG
G
V
A
R
----
L
F
T
K
V
Q
Q
I
R
R
A
--------
E
P
N
V
--------
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
--
I
E
P
L
L
KEA
K
F
P
I
L
S
A
N
I
-
K
A
K
--
G
----
P
---
L
------
A
SQISGL
Y
--
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
L
S
-
N
P
G
--
T
-
N
L
V
F
E
D
E
I
T
A
---
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
N
K
I
I
A
L
G
H
S
G
F
---------
E
---------------
M
------
D
K
L
I
A
Q
-----
K
V
-----
R
G
V
D
----
V
----
V
V
G
G
H
S
N
T
F
L
Y
T
G
-----------------
N
PPSKEVPAGKYP
F
I
V
T
S
D
D
G
R
K
V
P
V
V
Q
A
Y
---
A
F
G
K
Y
L
-
G
Y
L
K
---
I
E
F
D
E
R
G
N
--
V
I
S
S
H
G
N
P
I
L
L
N
S
---
S
I
-------
P
E
D
P
S
-------
I
K
A
D
I
N
K
W
R
I
K
L
D
N
Y
------
Q
E
L
G
---------------
K
T
------------
I
---
V
Y
-----
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
-
C
D
A
M
I
N
N
N
L
R
H
TDEM
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
RNN
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
-----
H
R
Y
G
Q
S
----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
--
C
T
K
C
R
V
P
--
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.02
27%
-33
- C2 -
1OIE
1
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGCN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
-------------
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
DNK-
C
---
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.77
27%
-36
- C2 -
4WWL
15
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
T
-------
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
C
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.75
27%
-34
- C2 -
1HPU
3
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
T
-------
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
PFQNKG
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.48
27%
-31
- C2 -
1USH
7
USHA_ECOLI
A:
[28-544]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
-----------------
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.10
27%
-34
- C2 -
1HO5
4
USHA_ECOLI
A:
[3-519]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
-
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
N
G
--
E
M
K
M
V
-
N
Y
Q
L
I
P
V
---
N
L
-------
K
K
K
V
T
-------
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
SPFQNKG
K
A
Q
L
E
V
------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
D
------
G
K
L
N
D
L
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NK
P
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.64
27%
-33
- C2 -
2USH
7
USHA_ECOLI
A:
[28-544]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
--------
F
-------
W
R
N
E
--------
Y
G
E
Y
-------
G
L
A
A
----
Q
K
T
----
L
V
D
G
--------
I
R
K
E
V
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A
E
G
G
S
V
L
L
L
S
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G
D
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N
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N
P
L
T
V
L
R
Q
Q
E
K
W
A
---
K
F
P
L
L
S
A
N
I
-
Y
Q
K
ST
G
----
E
---
R
------
L
------
F
--
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
------
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
--
K
-
P
-
D
I
I
I
A
A
T
H
M
G
H
Y
DNGEHGSN
A
P
G
D
V
E
M
A
---
R
----
A
LPAGSL
A
M
I
V
G
G
H
S
Q
D
P
V
C
MAAEN
K
K
Q
V
----
D
----
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
-----------------
G
-------------
I
W
---------
I
V
Q
A
H
---
E
W
G
K
Y
V
-
G
--
R
---
A
D
F
E
F
R
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G
--
E
M
K
M
V
-
N
Y
Q
L
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P
V
---
N
L
-------
K
K
K
V
-------------
S
E
R
V
L
Y
T
P
E
I
A
----
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
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------------
K
---
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
G
-----------
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
---
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
---
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
-------------
K
I
------------
K
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
----
D
NKP
G
Y
---
V
----
N
--
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
-----------------------------------------------------------------------------------------------------------------------------------