@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0041: (2016-03-11 )
MNDNEKRVLREIYNHHNISRTQISKNLEINKATISSILNKLKYKSLVNEVGEGDSTKSGGRKPILLKVNHLYGYFISLDLTYSSVEVMYNYFDGNVIKHESYDLPDEKVSSILSIIKKHIDIQEKLDTYNGLLGVSVSIHGVVDNEQHVTYLPFHETEGISIAKKIKEITNVPVVVENEANLSALYERNFNHNLSYNNLIALSIHKGIGAGLIINNQLYRGANGEAGEIGKTLVSKVSDNVEIFHKIEDIFSQEALLHNLSNQLNEKMTLSKLIQFYNEKNPVVVEEMEQFINKIAVLIHNLNTQFNPNAIYINCPLFNEMPEILEAIKNQFKQYSRNEIQIKLTSNVKFATLLGGTLAIIQKVLQINDIYLDIKA
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60........70........80........90........100.---....-.--.110......-.120-.-----.-......130.----......140.....-.-.-150-..-..--.-..-.-160.......170.......180.......190-------------.......200.......210.......220.......230........----------.240.-.--...--...250.---------------------......---260..----------.---------------.-----------------...270.......---.280..---......290..---------------.....300.......310.......320--.-----..-......330...----.----.------..340.......350.......360.......370....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MND
N
E
K
R
V
L
R
E
I
Y
N
HHNI
S
R
T
Q
ISKNLEI
N
K
A
T
I
S
S
I
L
N
K
L
K
Y
K
S
L
V
N
E
VGEGDSTKSGGRK
P
I
L
L
K
V
NH
L
Y
G
Y
F
I
S
L
D
L
T
YS
S
V
E
V
M
Y
N
YFDG
N
V
I
KHESYD---L
P
D
E
-
K
--
V
S
S
I
L
S
I
I
K
K
-
H
I
D
--
I
-----
Q
-
E
K
L
D
TYN
G
L
L
----
G
V
S
V
S
I
H
G
V
VDNEQ-
H
-
V
-
T
-
Y
-LP-FH--E-TE-
G
-
I
S
I
A
K
K
I
K
E
ITNV
P
V
V
V
ENEA
N
L
S
A
L
Y
ERNFNH-------------NLSYN
N
L
I
A
L
S
IHKGIG
A
G
L
I
INN
Q
L
YRGANGE
A
G
E
I
G
--
K
T
L
V
S
K
VS----------D
N
V
-
E
-
I
--
F
H
K
--
I
E
D
I
F
S
Q
---------------------
E
A
L
L
H
N
---
L
S
N
Q
L
----------
N
---------------
E
-----------------
K
M
T
L
-
S
K
L
I
Q
F
YN---EKN-P
V
---
V
V
E
E
M
E
Q
F
I
N
K
---------------
I
A
V
L
I
H
NLNTQFNP
N
A
I
Y
I
NC
P
L
F
N
E
----
M
-----
P
E
-
I
L
E
A
I
K
N
Q
F
K
QY----S----R------
N
E
I
Q
I
K
LTSN
V
K
F
A
T
LLG
G
T
L
A
I
I
Q
K
V
L
QI
N
D
I
Y
L
D
IKA-
1
PsiBlast_PDB
99.06
100%
-130
- C1 -
4IJA
9
?
A:
[22-397]
---
M
N
D
N
E
K
R
V
L
R
E
I
Y
N
H
H
N
I
S
R
T
Q
I
S
K
N
L
E
I
N
K
A
T
I
S
S
I
L
N
K
L
K
Y
K
S
L
V
N
E
V
G
-------
G
G
R
K
P
I
L
L
K
V
N
H
L
Y
G
Y
F
I
S
L
D
L
T
Y
S
S
V
E
V
M
Y
N
Y
F
D
G
N
V
I
K
H
E
S
Y
D
---
L
P
D
E
-
K
--
V
S
S
I
L
S
I
I
K
K
-
H
I
D
--
I
-----
Q
-
E
K
L
D
T
Y
N
G
L
L
----
G
V
S
V
S
I
H
G
V
V
D
N
E
Q
-
H
-
V
-
T
-
Y
-------------
G
-
I
S
I
A
K
K
I
K
E
I
T
N
V
P
V
V
V
E
N
E
A
N
L
S
A
L
Y
E
R
N
F
N
H
-------------
N
L
S
Y
N
N
L
I
A
L
S
I
H
K
G
I
G
A
G
L
I
I
N
N
Q
L
Y
R
G
A
N
G
E
A
G
E
I
G
--
K
T
L
V
S
K
V
S
----------
D
N
V
-
E
-
I
--
F
H
K
--
I
E
D
I
F
S
Q
---------------------
E
A
L
L
H
N
---
L
S
N
Q
L
----------
N
---------------
E
-----------------
K
M
T
L
-
S
K
L
I
Q
F
Y
N
---
E
K
N
-
P
V
---
V
V
E
E
M
E
Q
F
I
N
K
---------------
I
A
V
L
I
H
N
L
N
T
Q
F
N
P
N
A
I
Y
I
N
C
P
L
F
N
E
----
M
-----
P
E
-
I
L
E
A
I
K
N
Q
F
K
Q
Y
----
S
----
R
------
N
E
I
Q
I
K
L
T
S
N
V
K
F
A
T
L
L
G
G
T
L
A
I
I
Q
K
V
L
Q
I
N
D
I
Y
L
D
I
K
A
-
21
PsiBlast_CBE
98.56
100%
-127
- C1 -
4IJA
5
?
B:
[24-397]
-----
D
N
E
K
R
V
L
R
E
I
Y
N
H
H
N
I
S
R
T
Q
I
S
K
N
L
E
I
N
K
A
T
I
S
S
I
L
N
K
L
K
Y
K
S
L
V
N
E
V
-------------
I
L
L
K
V
N
H
L
Y
G
Y
F
I
S
L
D
L
T
Y
S
S
V
E
V
M
Y
N
Y
F
D
G
N
V
I
K
H
E
S
Y
D
---
L
P
D
E
-
K
--
V
S
S
I
L
S
I
I
K
K
-
H
I
D
--
I
-----
Q
-
E
K
L
D
T
Y
N
G
L
L
----
G
V
S
V
S
I
H
G
V
V
D
N
E
Q
-
H
-
V
-
T
-
Y
-
L
P
-
F
H
--
E
-
T
E
-
G
-
I
S
I
A
K
K
I
K
E
I
T
N
V
P
V
V
V
E
N
E
A
N
L
S
A
L
Y
E
R
N
F
N
H
-------------
N
L
S
Y
N
N
L
I
A
L
S
I
H
K
G
I
G
A
G
L
I
I
N
N
Q
L
Y
R
G
A
N
G
E
A
G
E
I
G
--
K
T
L
V
S
K
V
S
----------
D
N
V
-
E
-
I
--
F
H
K
--
I
E
D
I
F
S
Q
---------------------
E
A
L
L
H
N
---
L
S
N
Q
L
----------
N
---------------
E
-----------------
K
M
T
L
-
S
K
L
I
Q
F
Y
N
---
E
K
N
-
P
V
---
V
V
E
E
M
E
Q
F
I
N
K
---------------
I
A
V
L
I
H
N
L
N
T
Q
F
N
P
N
A
I
Y
I
N
C
P
L
F
N
E
----
M
-----
P
E
-
I
L
E
A
I
K
N
Q
F
K
Q
Y
----
S
----
R
------
N
E
I
Q
I
K
L
T
S
N
V
K
F
A
T
L
L
G
G
T
L
A
I
I
Q
K
V
L
Q
I
N
D
I
Y
L
D
I
K
A
-
23
HHSearch
69.54
22%
-93
- C1 -
1Z05
8
?
A:
[38-416]
----
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
K
G
P
I
S
R
I
D
L
S
K
E
S
E
L
A
P
A
S
I
T
K
I
T
R
E
L
I
D
A
H
L
I
H
E
T
T
V
Q
E
A
-
I
S
R
G
R
P
A
V
G
L
Q
T
N
N
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
K
I
D
---
I
H
E
I
-
D
--
Q
D
D
V
L
A
R
L
L
F
E
I
E
E
--
F
-----
F
Q
T
Y
A
A
Q
L
D
R
V
T
----
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
-
G
I
V
-
L
-
Q
-
M
P
-
H
Y
--
N
-
V
K
-
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
-------------
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
--
H
I
Q
I
D
P
Q
G
----------
K
R
C
H
C
G
N
--
Y
G
C
--
L
E
T
V
A
S
S
---------------------
Q
A
I
R
D
Q
---
V
T
A
R
I
----------
Q
---------------
A
G
E
P
S
CLATVE-------
E
I
S
I
-
E
D
I
C
A
A
A
A
---
D
G
D
-
P
L
---
A
V
D
V
I
Q
Q
L
G
R
Y
---------------
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
A
----
K
-----
S
I
-
L
Y
P
S
I
E
Q
C
I
R
E
Q
----
S
----
L
PVYH--
Q
D
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
---------------
47
Fugue
68.77
21%
-91
- C1 -
1Z05
8
?
A:
[34-429]
D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
K
G
P
I
S
R
I
D
L
S
K
E
S
E
L
A
P
A
S
I
T
K
I
T
R
E
L
I
D
A
H
L
I
H
E
T
T
V
Q
E
A
I
S
R
G
-
R
P
A
V
G
L
Q
T
N
N
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
K
I
D
---
I
H
E
I
-
D
--
Q
D
D
V
L
A
R
L
L
F
-
E
I
E
E
F
F
-----
Q
-
T
Y
A
A
Q
L
D
R
V
T
----
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
-
V
-
L
-
Q
-
M
P
-
H
Y
--
N
-
V
K
-
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
-------------
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
--
H
I
Q
I
D
P
Q
G
----------
K
R
C
-
H
-
C
--
G
N
Y
GC
L
E
T
V
A
S
S
---------------------
Q
A
I
R
D
Q
---
V
T
A
R
I
Q
A
G
E
P
S
CLAT
V
---------------
E
-----------------
E
I
S
I
-
E
D
I
C
A
A
A
A
---
D
G
D
-
P
L
---
A
V
D
V
I
Q
Q
L
G
R
Y
---------------
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
A
----
K
-----
S
I
-
L
Y
P
S
I
E
Q
C
I
R
E
Q
SLPV
Y
----
H
------
Q
D
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
Y
--
D
G
L
L
L
M
K
V
V
E
G
2
PsiBlast_PDB
65.46
22%
-81
- C1 -
1Z05
8
?
A:
[40-412]
------
N
A
G
R
V
Y
K
L
I
D
Q
K
G
P
I
S
R
I
D
L
S
K
E
S
E
L
A
P
A
S
I
T
K
I
T
R
E
L
I
D
A
H
L
I
H
E
T
T
V
Q
E
A
I
-
S
R
G
R
P
A
V
G
L
Q
T
N
N
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
K
I
D
---
I
H
E
I
-
D
--
Q
D
D
V
L
A
--
R
L
-
L
F
E
--
I
-----
E
-
E
F
F
Q
T
Y
A
A
Q
L
DRVT
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
-
G
-
I
-
V
-
L
Q
M
P
-
H
Y
--
N
-
V
K
-
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
-------------
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
--
H
I
Q
I
D
P
Q
G
----------
K
R
C
-
H
-
C
GN
Y
G
C
--
L
E
T
V
A
S
S
---------------------
Q
A
I
R
D
Q
---
V
T
A
R
I
----------
Q
A
G
E
P
S
CLATV-----
E
-----------------
E
I
S
I
-
E
D
I
C
A
A
A
A
---
D
G
D
-
P
L
---
A
V
D
V
I
Q
Q
L
G
R
Y
---------------
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
-
G
V
I
N
Q
----
A
K
S
I
L
Y
P
S
-
I
E
Q
C
I
R
E
Q
S
L
P
V
----
Y
----
H
------
Q
D
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
-------------------
24
HHSearch
65.22
23%
-93
- C1 -
2HOE
2
?
A:
[22-378]
-------
I
S
R
I
L
K
R
I
M
-
K
S
P
V
S
R
V
E
L
A
E
E
L
G
L
T
K
T
T
V
G
E
I
A
K
I
F
L
E
K
G
I
V
V
E
E
K
D
S
P
------
R
P
T
K
S
L
K
I
S
P
N
C
A
Y
V
L
G
I
E
V
T
R
D
E
I
A
A
C
L
I
D
A
S
M
N
I
L
A
H
E
A
H
P
---
L
P
S
Q
S
D
--
R
E
E
T
L
N
V
M
Y
R
I
I
D
R
--
A
-----
K
D
M
M
E
K
L
G
S
K
L
S
----
A
L
T
V
A
A
P
G
P
I
D
T
E
R
-
G
I
I
-
I
-
D
-
P
R
-
N
F
--
P
-
L
S
-
Q
-
I
P
L
A
N
L
L
K
E
K
Y
G
I
E
V
W
V
E
N
D
A
D
M
G
A
V
G
E
K
W
Y
T
K
---------------
R
D
D
S
F
A
W
I
L
T
G
K
G
I
G
A
G
I
I
I
D
G
E
L
Y
R
G
E
N
G
Y
A
G
E
I
G
--
Y
T
R
V
F
N
G
N
----------------
E
--
Y
V
F
--
L
E
D
V
C
N
E
---------------------
N
V
V
L
K
H
---
V
L
S
-----------------------------------------------
M
G
F
-
S
-
L
A
E
A
R
D
---
S
G
D
-
V
R
---
V
K
E
Y
F
D
D
I
A
R
Y
---------------
F
S
I
G
L
L
N
L
I
H
L
F
G
I
S
K
I
V
I
G
G
F
F
K
E
L
----
G
-----
E
N
-
F
L
K
K
I
K
I
E
V
E
T
H
----
L
----
L
Y
K
----
H
S
V
D
M
S
F
S
K
V
Q
E
P
V
I
A
F
G
A
A
V
H
A
L
E
N
Y
L
E
R
V
T
--------
4
PsiBlast_PDB
64.14
22%
-102
- C1 -
1Z6R
1
MLC_ECOLI
A:
[17-389]
------
N
A
G
A
V
Y
R
L
I
D
Q
L
G
P
V
S
R
I
D
L
S
R
L
A
Q
L
A
P
A
S
I
T
K
I
V
H
E
M
L
E
A
H
L
V
Q
E
L
--------------
G
L
V
V
E
T
E
A
W
H
Y
L
S
L
R
I
S
R
G
E
I
F
L
A
L
R
D
L
S
S
K
L
V
V
E
E
S
Q
E
---
L
A
L
K
-
D
--
D
L
P
L
L
D
R
I
I
S
-
H
I
D
--
Q
F
F
I
R
H
Q
-
K
K
L
E
R
---
L
T
----
S
I
A
I
T
L
P
G
I
I
D
T
E
N
-
G
-
I
-
V
-
H
R
M
P
-
F
Y
--
E
D
V
K
-
E
-
M
P
L
G
E
A
L
E
Q
H
T
G
V
P
V
Y
I
Q
H
D
I
S
A
W
T
M
A
E
A
L
F
G
A
-------------
S
R
G
A
R
D
V
I
Q
V
V
I
D
H
N
V
G
A
G
V
I
T
D
G
H
L
L
H
A
G
S
S
S
L
V
E
I
G
--
H
T
Q
V
D
P
Y
G
----------
K
R
C
-
Y
-
C
--
G
N
H
GC
L
E
T
I
A
S
V
---------------------
D
S
I
L
E
L
---
A
Q
L
R
L
----------
N
Q
S
MSSMLHG------
Q
-----------------
P
L
T
V
-
D
S
L
C
Q
A
A
L
---
R
G
D
-
L
L
A
K
D
I
I
T
G
V
G
A
H
V
G
R
---------------
I
L
A
I
M
V
N
L
---
F
N
P
Q
K
I
L
I
G
S
P
L
S
K
A
ADI
L
F
-----
P
V
-
I
S
D
S
I
R
Q
Q
A
L
P
A
----
Y
----
S
------
Q
H
I
S
V
E
S
T
Q
F
S
N
Q
G
T
M
A
G
A
A
L
-------------------
22
HHSearch
63.43
19%
-95
- C1 -
1Z6R
1
MLC_ECOLI
A:
[15-400]
----
Q
T
N
A
G
A
V
Y
R
L
I
D
Q
L
G
P
V
S
R
I
D
L
S
R
L
A
Q
L
A
P
A
S
I
T
K
I
V
H
E
M
L
E
A
H
L
V
Q
E
L
--------------
G
L
V
V
E
T
E
A
W
H
Y
L
S
L
R
I
S
R
G
E
I
F
L
A
L
R
D
L
S
S
K
L
V
V
E
E
S
Q
E
---
L
A
L
K
-
D
--
D
L
P
L
L
D
R
I
I
S
H
I
D
Q
--
F
-----
F
I
R
H
Q
K
K
L
E
R
L
T
----
S
I
A
I
T
L
P
G
I
I
D
T
E
N
-
G
I
V
-
H
-
R
-
M
P
F
Y
E
--
D
-
V
K
-
E
-
M
P
L
G
E
A
L
E
Q
H
T
G
V
P
V
Y
I
Q
H
D
I
S
A
W
T
M
A
E
A
L
F
G
A
-------------
S
R
G
A
R
D
V
I
Q
V
V
I
D
H
N
V
G
A
G
V
I
T
D
G
H
L
L
H
A
G
S
S
S
L
V
E
I
G
--
H
T
Q
V
D
P
Y
G
----------
K
R
C
Y
C
G
N
--
H
G
C
--
L
E
T
I
A
S
V
---------------------
D
S
I
L
E
L
---
A
Q
L
R
L
----------
N
---------------
Q
S
MSSMLHGQ--------
P
L
T
V
-
D
S
L
C
Q
A
A
L
---
R
G
D
-
L
L
---
A
K
D
I
I
T
G
V
G
A
H
---------------
V
G
R
I
L
A
I
M
V
N
L
F
N
P
Q
K
I
L
I
G
S
P
L
S
K
A
----
A
-----
D
I
-
L
F
P
V
I
S
D
S
I
R
Q
Q
----
A
----
L
PAYS--
Q
H
I
S
V
E
S
T
Q
F
S
N
Q
G
T
M
A
G
A
A
-
L
V
K
D
A
M
Y
N
G
S
L
L
-------
32
HHSearch
63.32
21%
-85
- C1 -
3VGL
4
?
A:
[2-313]
---------------------------------------------------------------------------
G
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
---
T
P
P
--
T
--
A
E
G
I
V
D
A
I
C
A
A
V
A
G
--
A
-----
S
-----
E
G
H
D
V
E
----
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
-
A
T
V
-
L
-
F
-
A
P
-
N
I
--
D
-
W
R
-
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
-------------
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
--
H
I
R
V
V
P
D
G
----------
L
L
C
G
C
G
S
--
Q
G
C
--
W
E
Q
Y
A
S
G
---------------------
R
A
L
V
R
Y
---
A
K
Q
R
A
----------
N
---------------
A
TPENA
A
V
L
L
G
L
G
DGSVD
G
I
E
G
-
K
H
I
S
E
A
A
R
---
Q
G
D
-
P
V
---
A
V
D
S
F
R
E
L
A
R
W
---------------
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
----
G
-----
E
L
-
V
L
D
P
I
R
K
S
F
R
R
W
----
L
----
I
GGEW
R
-
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
G
--------------
35
HHSearch
61.37
17%
-98
- C1 -
3VOV
3
?
A:
[2-300]
----------------------------------------------------------------------------
K
V
V
G
L
D
L
G
G
T
K
I
A
A
G
V
F
D
G
-
K
R
L
L
S
K
V
V
V
P
---
T
P
K
E
-
G
--
G
E
R
V
A
E
A
L
A
E
A
A
E
R
--
A
-----
E
-
R
E
--
A
G
V
R
G
E
----
A
I
G
L
G
T
P
G
P
L
D
F
R
R
-
G
V
I
-
R
-----N
I
P
--
G
-
V
Q
-
D
-
F
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
-------------
A
Q
G
E
E
S
S
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
--
H
L
T
L
L
P
G
G
----------
P
A
C
G
C
G
L
--
E
G
C
--
L
E
A
L
A
A
G
---------------------
R
A
L
E
R
D
---
A
T
Y
A
F
----------
Q
---------------
R
-----------------
P
V
D
T
-
R
E
L
F
R
L
F
Q
---
A
G
D
-
P
K
---
A
E
R
L
V
L
Q
A
A
R
Y
---------------
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
N
----
A
P----
E
G
-
Y
W
E
A
L
L
E
A
Y
R
R
Y
----
L
----
Q
G
W
----
E
A
P
P
L
R
R
A
R
L
G
A
E
A
G
L
L
G
A
A
L
T
A
Y
L
E
V
K
D
G
----------
26
HHSearch
59.42
15%
-93
- C1 -
2AP1
1
NAGK_SALTY
A:
[23-326]
-------------------------------------------------------------------------
N
A
-
M
Y
Y
G
F
D
I
G
G
T
K
I
A
L
G
V
F
D
S
T
R
R
L
Q
W
E
K
R
V
P
---
T
P
H
T
-
S
--
Y
S
A
F
L
D
A
V
C
E
L
V
E
E
--
A
-----
D
-
Q
---
R
F
G
V
K
G
----
S
V
G
I
G
I
P
G
M
P
E
T
E
D
-
G
T
L
-
Y
-
A
-
A
N
-
V
P
--
A
-
A
S
-
G
-
K
P
L
R
A
D
L
S
A
R
L
D
R
D
V
R
L
D
N
D
A
N
C
F
A
L
S
E
A
W
D
D
E
-------------
F
T
Q
Y
P
L
V
M
G
L
I
L
G
T
G
V
G
G
G
L
V
L
N
G
K
P
I
T
G
Q
S
Y
I
T
G
E
F
G
--
H
M
R
L
P
V
D
A
L
T
L
M
GFDFPL
R
R
C
G
C
G
Q
--
M
G
C
--
I
E
N
Y
L
S
G
---------------------
R
G
F
A
W
L
---
Y
Q
H
Y
Y
----------
D
---------------
Q
-----------------
S
L
Q
A
-
P
E
I
I
A
L
W
E
---
Q
G
D
-
E
Q
---
A
H
A
H
V
E
R
Y
L
D
L
---------------
L
A
V
C
L
G
N
I
L
T
I
V
D
P
D
L
L
V
I
G
G
G
L
S
N
F
----------
T
A
-
I
T
T
Q
L
A
E
R
L
P
R
H
----
L
LPV-
A
------
R
A
P
R
I
E
R
A
R
H
G
D
A
G
G
M
R
G
A
A
F
L
H
L
T
---------------
29
HHSearch
59.38
18%
-97
- C1 -
2QM1
5
?
A:
[2-323]
-----------------------------------------------------------------------
N
A
M
D
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
S
I
E
---
T
N
I
L
E
D
--
G
K
H
I
V
P
S
I
I
E
S
I
R
H
--
R
-----
I
D
L
Y
N
M
K
K
E
D
F
V
----
G
I
G
M
G
T
P
G
S
V
D
I
E
K
-
G
T
V
-
V
-
G
-
A
Y
-
N
L
--
N
-
W
T
-
T
V
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
-------------
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
--
H
V
T
V
D
P
N
G
----------
F
D
C
T
C
G
K
--
R
G
C
--
L
E
T
V
S
S
A
---------------------
T
G
V
V
R
V
---
A
R
H
L
S
----------
E
EFAGDS
E
L
K
Q
A
I
D
D
G
Q
-----------------
D
V
S
S
-
K
D
V
F
E
F
A
E
---
K
G
D
-
H
F
---
A
L
M
V
V
D
R
V
C
F
Y
---------------
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
A
----
G
-----
E
F
-
L
R
S
R
V
E
K
Y
F
Q
E
F
----
T
----
F
P
Q
V
R
--
N
S
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
F
S
-------------
38
HHSearch
58.66
19%
-99
- C1 -
2GUP
4
?
A:
[4-290]
---------------------------------------------------------------------------
M
T
I
A
T
I
D
I
G
G
T
G
I
K
F
A
S
L
T
P
D
G
K
I
L
D
K
T
S
I
S
---
T
P
E
--
N
--
L
----
E
D
L
L
A
W
L
D
Q
--
R
-----
L
-----
S
E
Q
D
Y
S
----
G
I
A
M
S
V
P
G
A
V
N
Q
E
T
-
G
-
V
I
D
-
G
F
S
A
-
V
P
--
Y
-
I
H
-
G
-
F
S
W
Y
E
A
L
S
-
S
Y
Q
L
P
V
H
L
E
N
D
A
N
C
V
G
L
S
E
L
L
A
H
P
---------------
E
L
E
N
A
A
C
V
V
I
G
T
G
I
G
G
A
M
I
I
N
G
R
L
H
R
G
R
H
G
L
G
G
E
F
G
--
Y
M
T
T
L
A
P
A
----------
E
-----
K
--
L
N
N
--
W
S
Q
L
A
S
T
---------------------
G
N
M
V
R
Y
---
V
I
E
K
S
----------
G
---------------
H
T----------------
D
W
D
G
-
R
K
I
Y
Q
E
A
A
---
A
G
N
-
I
L
---
C
Q
E
A
I
E
R
M
N
R
N
---------------
L
A
Q
G
L
L
N
I
Q
Y
L
I
D
P
G
V
I
S
L
G
G
S
I
S
Q
N
----------
P
D
-
F
I
Q
G
V
K
K
A
V
E
D
F
----
V
----
D
A
Y
EEYT
V
A
P
V
I
Q
A
C
T
Y
H
A
D
A
N
L
Y
G
A
L
V
N
W
L
Q
E
E
K
------------
10
PsiBlast_PDB
58.15
21%
-95
- C1 -
2QM1
5
?
A:
[9-321]
------------------------------------------------------------------------------
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
S
I
E
T
N
I
L
E
D
G
-
K
H
I
V
P
S
I
I
E
S
I
R
H
-
R
I
D
--
L
Y
N---
M
-
K
K
E
D
----
F
V
----
G
I
G
M
G
T
P
G
S
V
D
I
E
K
-
G
-
T
-
V
-
V
-
G
A
-
Y
N
LN
W
-
T
T
-
V
-
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
-------------
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
--
H
V
T
V
D
P
N
G
----------
F
D
C
-
T
-
C
--
G
K
R
GC
L
E
T
V
S
S
A
---------------------
T
G
V
V
R
----
V
A
R
H
L
----------
S
---------------
E
-----------------
E
F
A
G
D
S
E
L
K
Q
A
I
D
---
D
G
Q
-
D
V
---
S
S
K
D
V
F
E
F
A
E
K
GD
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
A
----
G
-----
E
F
-
L
R
S
R
V
E
K
Y
F
Q
E
F
----
T
F
P
Q
V
R
------
N
S
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
---------------
37
HHSearch
56.42
14%
-92
* C1 *
2AA4
1
NANK_ECOLI
A:
[1-289]
---------------------------------------------------------------------------
M
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
R
E
L
P
---
T
P
A
S
Q
T
--
P
E
A
L
R
D
A
L
S
A
L
V
S
P
--
L
------------
Q
A
H
A
Q
----
R
V
A
I
A
S
T
G
I
I
R
D
G
S
-
L
-
L
-
A
L
N
-
P
H
N
L
G
--
G
-
L
L
-
H
-
F
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
--------------
G
D
I
T
D
M
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
--
H
T
L
A
D
P
H
G
----------
P
V
C
G
C
G
R
--
T
G
C
--
V
E
A
I
A
S
G
---------------------
R
G
I
A
A
A
---
A
Q
G
E
L
----------
A
---------------------------------
G
A
D
A
-
K
T
I
F
T
R
A
G
---
Q
G
D
-
E
Q
---
A
Q
Q
L
I
H
R
S
A
R
T
---------------
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
A
----------
E
G
-
Y
L
A
L
V
E
T
Y
L
A
Q
E
----
P
A---
A
------
F
H
V
D
L
L
A
A
H
Y
R
H
D
A
G
L
L
G
A
A
L
L
A
Q
G
E
--------------
8
PsiBlast_PDB
52.69
22%
-92
- C1 -
4HTL
1
BGLK_LISMO
A:
[97-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
L
P
V
A
I
E
N
D
A
N
C
A
L
L
A
E
K
W
L
G
K
-------------
G
Q
D
L
D
D
F
L
C
L
T
I
G
T
G
I
G
G
G
I
F
S
N
G
E
L
V
R
G
G
R
F
R
A
G
E
F
G
--
Y
M
F
S
E
R
P
G
----------
A
F
R
-
P
-
G
--
K
Y
T
--
L
N
E
T
T
T
M
---------------------
L
V
L
R
R
Q
Y
A
E
L
T
G
R
P
----------
L
---------------
E
-----------------
E
I
T
G
-
E
E
I
F
A
N
Y
D
---
A
H
D
-
A
V
---
S
E
R
L
I
T
E
F
Y
T
G
---------------
I
C
T
G
L
Y
N
L
I
Y
L
F
D
P
T
H
I
F
I
G
G
G
I
-
T
S
----
R
-----
P
T
-
F
I
A
E
L
K
H
H
M
E
S
F
----
G
----
L
------
R
D
T
I
I
E
T
A
T
H
K
N
Q
A
G
L
L
G
A
V
Y
H
F
L
Q
E
--------------
7
PsiBlast_PDB
52.50
22%
-88
- C1 -
3VGM
3
?
A:
[60-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
G
A
A
G
Y
V
D
D
K
R
-
A
T
V
-
L
-
F
-
A
P
-
N
I
--
D
-
W
R
-
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
-------------
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
--
H
I
R
V
--
V
P
----------
D
G
L
-
L
-
C
--
G
C
G
--
S
Q
G
C
W
E
Q
YAS
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
TPEN
A
A
V
L
L
G
---
L
G
D
G
S
----------
V
---------------
D
-----------------
G
I
E
G
-
K
H
I
S
E
A
A
R
---
Q
G
D
-
P
V
---
A
V
D
S
F
R
E
L
A
R
W
---------------
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
----
G
-----
E
L
-
V
L
D
P
I
R
K
S
F
R
R
W
--------------------------------------------------------
40
HHSearch
51.95
16%
-93
- C1 -
3MCP
3
?
A:
[4-321]
----------------------------------------------------------------------
Y
T
N
D
N
R
I
V
M
T
L
D
A
G
G
T
N
F
V
F
S
A
I
Q
G
G
K
E
I
A
D
P
V
V
L
P
---
A
C
A
D
-
C
--
L
D
K
C
L
G
N
L
V
E
G
F
K
A
--
I
-----
Q
-
A
--
G
L
P
E
A
P
V
----
A
I
S
F
A
F
P
G
P
A
D
Y
Q
A
-
G
I
I
-
G
-
D
-
L
P
N
F
P
--
S
-
F
R
G
G
-
V
A
L
G
P
F
L
E
D
I
F
G
I
P
V
F
I
N
N
D
G
S
L
F
A
Y
G
E
A
L
T
G
V
L
P
E
I
N
R
R
L
R
E
A
GS
T
K
R
Y
K
N
L
L
G
V
T
L
G
T
G
F
G
A
G
V
V
I
D
G
E
L
L
R
G
D
N
A
A
G
G
Y
V
W
--
C
L
R
N
K
K
----------------
Y
-
P
--
E
Y
I
--
V
E
E
S
V
S
I
---------------------
R
A
V
M
R
V
---
Y
A
E
R
S
----------
G
---------------
D
AG---------------
A
R
T
P
-
K
E
I
F
E
I
A
E
GIR
P
G
N
R
E
A
---
A
I
A
A
F
E
E
L
G
E
M
---------------
A
G
D
A
L
A
S
A
I
T
L
I
D
-
G
L
I
V
I
G
G
G
L
S
G
A
----
S
-----
K
Y
-
I
L
P
V
L
L
K
E
M
N
A
Q
----
T
G
M
M-----------
Q
K
E
V
Y
D
L
D
E
E
K
S
F
A
G
F
A
R
G
E
A
V
E
--------------
16
PsiBlast_PDB
51.65
21%
-85
- C1 -
3VOV
3
?
A:
[68-266]
----------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
F
R
R
G
V
I
----
R
---
N
I
P
G
V
Q
D
--------------------------
F
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
-------------
A
Q
G
E
E
S
S
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
HL
T
L
L
P
G
G
P
A
----------
C
G
C
-
G
-
L
--
E
G
C
--
L
E
A
L
A
A
G
---------------------
R
A
L
E
R
D
---
A
T
Y
A
F
----------
Q
---------------
R
-----------------
P
V
D
T
-
R
E
L
F
R
L
F
Q
---
A
G
D
-
P
K
---
A
E
R
L
V
L
Q
A
A
R
Y
---------------
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
N
----
A
-----
P
E
G
Y
W
E
A
L
L
E
A
Y
R
R
Y
--------------------------------------------------------
5
PsiBlast_PDB
51.52
22%
-83
- C1 -
3VGK
1
?
A:
[60-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
G
A
A
G
Y
V
D
D
K
R
-
A
T
V
-
L
-
F
-
A
P
-
N
I
--
D
-
W
R
-
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
-------------
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
--
H
I
R
V
--
V
P
----------
D
G
L
-
L
-
C
--
G
C
G
--
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
TPEN
A
A
V
L
L
G
---
L
G
D
G
S
----------
V
---------------
D
-----------------
G
I
E
G
-
K
H
I
S
E
A
A
R
---
Q
G
D
-
P
V
---
A
V
D
S
F
R
E
L
A
R
W
---------------
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
E
----
G
-----
E
L
-
V
L
D
P
I
R
K
S
F
R
R
W
--------------------------------------------------------