@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0067: (2016-03-11 )
MYLGYSPGVGKTYEMLSNGIDQYQEGADIKIGYIEPHQRPETNALVQQLPEISTSSRKFGSHTFHYIDVSKIIEANPDVVLIDELAHTNISKERHLKRYKDIEEILSHGIDVWTTLNIQHIESLSGQIALMTGIQVTERVPDQFITSADAFEVVDISPNMLIQRLKAGKVYKKERLETAFSNFFTYENLTELRELTLRTVADIMSQKGQQYKTKHTDITPHIAVAISGSIYNERVIREARRAAYKEHAKFTAVYIDVFETPSESRKQDHYVHKNLMLAKALGAEIKVLYAQDIAKALTDWCDLAFVTKLVLGQSEQPRWKDYFKQSLIEQINHVPHHFKLEIVPIHYIHSDKPTNTPKQAQKSSRLTVEIMKMLVIQTICVLLGIWVYNLDKSESSAIILLMFFIGIIVLSIWTQSYLIGFFASILNVFVFNYFFTVPRFTLEMYRFEYPITFATSIFASIFTSAILKNLKHQHSLTERQLYRTNIMLQFNQSIKESYSIERLLNIAGDQIHQLLNQDVTVFLIQSKKVAASNSFGNRSISSSDKTHDAETLSWVIENESRAGKLTDTFPGSKFLCIPIGTNPVKGVISIRFTDETYIDTYDNSILDSMLNDITLAIENVDLLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLTVNPIEMEGAMDENNIIGR
Atome Classification :
(20 SA)
------.........10...-.....20........30.........40........50........60-......-..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190..-.-....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......---570.......580.......590.......600.....--..610.......620........630.--------......640.......650.......660.......670---......-..-.680....--...690.......700---....----.---..710...-------....720.......730....----------.--..--.-----740...-...--.---------..750.......760.......770.-------.-------.-------....780.......790.......800.......810...--.------...820.......830....-...840.......850......--.860.......870.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MYLGYSPGV
G
K
T
Y
E
-
M
L
S
N
G
I
D
Q
Y
QEGA
D
I
K
-
I
G
Y
IEPHQRP
E
T
N
A
L
V
Q
QLPEISTSSRKFGS-
H
T
F
H
Y
I
-
D
V
S
K
I
IEANP
D
V
V
L
I
D
E
L
AHTNI
S
K
E
R
H
L
K
R
Y
K
D
I
E
E
I
L
SHGI
D
V
W
T
T
L
N
I
Q
H
I
E
SLSG
Q
I
A
L
M
TGI
Q
V
T
E
RV
P
D
Q
FITSAD
A
F
E
V
V
DI
S
P
N
M
L
I
Q
R
L
KAGK
V
Y
K
K
E
R
L
E
T
A
F
S
N
FF
T
Y
E
N
L
T
E
L
R
E
-
L
-
T
L
R
T
V
A
D
I
M
S
QKGQQYKTKHTDIT
P
H
I
A
V
A
ISGSI
Y
N
E
R
V
I
R
E
A
R
R
A
A
Y
K
E
HA
K
F
T
A
V
Y
I
D
V
FETPSESRKQ
D
H
Y
V
H
K
N
L
M
L
A
K
ALGA
E
I
K
V
L
Y
A
Q
D
I
A
K
A
L
T
DW
C
D
L
A
F
V
T
K
L
V
LGQSEQ
P
R
W
K
D
Y
F
K
Q
S
L
I
E
Q
I
NHVP
H
H
F
K
L
E
I
V
P
I
H
Y
I
HSDKPTNT
P
K
Q
A
Q
KSS
R
L
T
V
E
I
M
K
M
L
V
I
Q
T
I
C
V
L
L
G
I
W
V
YNLDKSES
S
A
I
I
L
L
M
F
F
I
G
I
I
V
L
S
I
W
T
Q
S
Y
L
I
G
F
F
A
S
I
L
N
V
F
V
F
N
Y
F
FTV
P
R
F
T
L
E
M
Y
R
F
EYP
I
T
F
A
T
S
I
F
A
S
I
F
T
S
A
I
L
K
N
L
K
H
Q
H
S
L
T
E
R
Q
L
Y
R
T
N
I
M
L
Q
F
N
Q
S
I
K
E
S
Y
S
I
E
R
L
L
N
IA
G
D
Q
I
H
Q
L
L
NQD
V
T
V
F
L
I
QS
K
K
VAASNSFGNRSISSSDKTHDAE
T
L
S
W
V
IENESRAGKLTDTF---PGS
K
F
L
C
I
PIGTNP
V
K
G
V
I
S
I
R
FTDE
T
Y
IDTY
D
N
S
I
L
D
--
S
M
L
N
D
I
T
L
A
IE
N
V
D
-
L
L
K
Q
T
R
Q
S
I
L
K
A
--------
E
R
E
A
T
R
S
N
F
L
H
S
I
S
H
D
I
R
T
P
L
T
S
I
MG
N
L
D
M
L
K
Y
H
N
E
H-----L
N
D
Q
Q
Q
-
A
E
-
L
L
T
ASYG
E
--
A
Q
Y
L
H
T
L
V
T
N
I
L
S
L
TK---LESS----D---
I
Q
I
QR
T
P
Y
-------
L
V
E
E
L
L
E
E
F
E
E
G
L
I
R
R-HQA
N
----------
H
--
V
I
--
I
-----E--NED-DA
S
--
L
---------INI
D
S
K
L
I
L
Q
V
L
F
N
L
I
D
N
A
L
K
H
AESH-------
S
-------
E
-------
I
K
L
H
V
Q
HET
N
K
I
K
F
E
M
IDCGKGI
P
E
E
E
R
Q
L
I
FNPYYSGDN--F------KDNKKDSL
G
L
G
L
Y
L
V
Q
L
I
L
K
-QHNSELEYQPNTPQG
S
I
F
Y
F
Y
L
--
T
VN
P
I
E
MEGAMDENNIIGR
17
PsiBlast_PDB
73.75
25%
-73
- C1 -
4JAV
6
?
A:
[20-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
D
L
C
D
---
L
V
E
S
A
V
N
A
I
K
E
-
F
A
S
S
-
H
N
V
N
----------
V
--
L
F
--
E
-----
S
--
N
V
P
-
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
-------
P
D
K
Y
----
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
---------------------
16
PsiBlast_PDB
71.79
25%
-70
- C1 -
3DGE
3
?
A:
[20-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
D
L
C
D
---
L
V
E
S
A
V
N
A
I
K
E
-
F
A
S
S
-
H
N
V
N
----------
V
--
L
F
--
E
-----
S
--
N
V
P
-
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
-------
P
D
K
Y
----
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
---------------------
5
PsiBlast_PDB
71.58
23%
-69
- C1 -
4U7O
1
?
A:
[35-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
--
D
G
A
-----
W
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
--
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
---
M
D
S
G
T
T
R
V
D
---
M
E
L
V
N
I
N
E
-------
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
N
P
A
K
----------
Y
--
Y
T
--
I
-----
K
--
R
E
F
-
T
K
R
D
L
W
---------
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
-------
G
-------
V
-------
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-------------
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
--
P
Y
E
----------------
11
PsiBlast_PDB
71.46
25%
-73
- C1 -
4JAS
2
?
A:
[20-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
T
I
I
E
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
D
L
C
D
---
L
V
E
S
A
V
N
A
I
K
E
-
F
A
S
S
-
H
N
V
N
----------
V
--
L
F
--
E
-----
S
--
N
V
P
-
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
-------
P
D
K
Y
----
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
---------------------
12
PsiBlast_PDB
70.54
25%
-88
- C1 -
4JAU
1
?
A:
[20-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
T
I
I
E
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
D
L
C
D
---
L
V
E
S
A
V
N
A
I
K
E
-
F
A
S
S
-
H
N
V
N
----------
V
--
L
F
--
E
-----
S
--
N
V
P
-
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
-------
P
D
K
Y
----
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
-----------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
---------------------
18
PsiBlast_PDB
69.75
25%
-87
- C1 -
2C2A
2
?
A:
[20-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
D
L
C
D
---
L
V
E
S
A
V
N
A
I
K
E
-
F
A
S
S
-
H
N
V
N
----------
V
--
L
F
--
E
-----
S
--
N
V
P
-
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
-------
P
D
K
Y
----
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
---------------------
44
Fugue
69.35
20%
-33
- C1 -
4I5S
-
?
A:
[37-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
---
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
------
I
T
L
R
--
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
--------
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
--
D
G
A
-----
L
T
E
S
V
A
-
P
S
-
F
I
K
V
S
L
D
E
--
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
---
S
H
L
-----
D
---
V
E
L
T
N
F
T
A
-------
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
--
S
-
Q
Q
S
T
----------
E
--
I
I
--
R
-----
D
--
Y
P
D
-
K
S
V
--
W
---------
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
-------
G
-------
K
-------
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
------
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
--
P
------------------
21
HHSearch
68.81
41%
-55
- C2 -
2R8R
6
?
A:
[9-211]
------
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
-
M
L
Q
A
A
H
A
Q
L
R
Q
G
V
R
V
M
-
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
-
M
T
L
E
E
M
-
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
-
M
-
A
M
Q
T
A
A
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
66.98
23%
-90
- C- -
2C2A
2
?
A:
[16-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-----
L
D
L
S
T
L
-
K
E
-
F
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
---
L
E
R
K
----
S
---
L
Q
I
N
R
E
K
V
-------
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
-
A
S
S
H
----------
N
--
V
N
--
V
-----
L
F
E
S
N
V
P
C
P
V
--
E
---------
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
P
D
K
----
Y
-------
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-----------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
--
P
K
D
R
A
--------------
3
PsiBlast_PDB
66.66
24%
-55
- C1 -
4Q20
-
DIVL_CAUCR
A:
[34-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
E
A
E
R
L
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
-
R
A
D
-------
S
E
R
G
R
-
N
H
-
V
-
A
A
V
R
A
A
--
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
---
I
D
A
G
----
E
---
M
A
L
E
I
E
D
I
-------
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
-
A
Q
L
G
----------
G
--
V
T
L
A
V
-----
E
--
C
E
E
-
D
V
G
--
L
---------
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
-------
G
-------
R
-------
V
T
L
S
A
R
R
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
------
D
R
--
F
------
V
G
R
D
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
Q
-----------------
43
Fugue
66.22
41%
-58
* C2 *
2R8R
6
?
A:
[3-211]
A
R
G
R
L
K
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
M
L
Q
-
A
A
H
A
Q
L
R
Q
G
V
R
V
-M
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
M
T
--
L
E
E
M
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
M
A
M
Q
T
A
A
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.06
43%
-48
- C2 -
2R8R
6
?
A:
[9-202]
------
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
-
M
L
Q
A
A
H
A
Q
L
R
Q
G
V
R
V
M
-
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
-
M
T
L
E
E
M
-
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.88
23%
-70
- C1 -
4U7N
-
?
A:
[39-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
--
D
G
A
-----
W
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
--
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
---
M
D
S
G
TTRV
D
---
M
E
L
V
N
I
N
E
-------
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
N
-------------
Y
--
Y
T
--
I
-----
K
--
R
E
F
-
T
K
R
D
L
W
---------
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
-------
G
-------
V
-------
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-------------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
--
P
Y
E
----------------
46
Fugue
61.54
15%
-42
- C1 -
1JM6
2
PDK2_RAT
A:
[11-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
A
G
A
P
K
Y
I
E
H
F
S
K
F
S
P
S
P
L
S
M
K
Q
F
L
D
F
G
A
C
E
K
T
S
F
T
F
L
R
Q
E
L
P
V
R
L
A
N
I
M
K
E
I
N
L
L
P
D
R
V
L
S
T
P
S
V
Q
L
-
V
Q
S
W
Y
V
Q
S
L
L
D
I
M
E
F
L
DKDP
E
D
H
R
T
L
S
Q
F
T
D
A
L
V
T
-
I
R
N
R
H
N
D
V
V
P
T
M
A
Q
G
V
L
E
Y
D
P
-----
V
S
N
Q
N
I
-
Q
Y
-
F
L
D
R
F
Y
L
S
--
R
I
S
I
R
M
L
I
N
Q
H
T
L
I
F
D
---
P
K
H
I
----
G
----
S
I
D
P
N
C
S
-------
V
S
D
V
V
K
D
A
Y
D
M
A
K
L
L
C
-
D
K
Y
Y
----------
M
--
A
S
--
P
-----
D
--
L
E
I
-
Q
E
V
--
N
ATNATQ
P
I
H
M
V
Y
V
P
S
H
L
Y
H
M
L
F
E
L
F
K
N
A
M
R
A
T
V
E
S
-------
H
-------
E
SSLTL
P
P
I
K
I
M
V
A
L
G
E
E
D
L
S
I
K
M
S
D
R
G
G
G
V
P
L
R
K
I
E
R
L
F
S
Y
M
Y
S
------------
T
A
P
T
P
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
-
Y
F
Q
G
D
L
Q
L
F
S
M
E
G
F
G
T
D
A
V
I
Y
L
--
K
A
L
S
T
D
S
V
E
R
L
P
V
Y
-----
26
HHSearch
61.28
16%
-57
- C1 -
2Q8G
1
PDK1_HUMAN
A:
[104-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
Y
D
F
T
D
T
V
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
I
E
Y
K
E
S
FDP--
V
T
S
Q
N
V
-
Q
Y
-
F
L
D
R
F
Y
M
S
--
R
I
S
I
R
M
L
L
N
Q
H
S
L
L
F
G
--------------------
K
H
I
GSINPNC
N
V
L
E
V
I
K
D
G
Y
E
N
A
R
R
L
-
C
D
L
Y
YI
N
S
P
-----
E
--
L
E
--
L
E
E
L
NA
K
--
S
P
G
-
Q
P
I
--
Q
---------
V
V
Y
V
P
S
H
L
Y
H
M
V
F
E
L
F
K
N
A
M
R
A
T
M
E
H
H
ANRG
V
Y
P
-------
P
-------
I
Q
V
H
V
T
L
G
N
E
D
L
T
V
K
M
S
D
R
G
G
G
V
P
L
R
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
--
R
PRVETS
R
A
V
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
Q
-
Y
F
Q
G
D
L
K
L
Y
S
L
E
G
Y
G
T
D
A
V
I
Y
I
--
K
A
L
S
T
D
S
------------
2
PsiBlast_PDB
60.15
25%
-55
- C1 -
4I5S
-
?
A:
[211-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
--
D
D
G
A
-----
L
T
E
S
V
A
-
P
S
-
F
I
K
V
S
L
D
E
--
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-------S
H
L
-
D
---
V
E
L
T
N
F
T
A
-------
F
M
N
Y
I
L
D
R
F
D
Q
--
I
Q
S
-
Q
Q
S
T
-----------E-
I
I
--
R
-----
D
--
Y
P
D
-
K
S
V
--
W
---------
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
-------
G
-------
K
-------
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
------
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
---------------------
22
HHSearch
60.13
16%
-52
- C1 -
2E0A
2
PDK4_HUMAN
A:
[91-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Q
K
A
L
S
D
F
V
D
T
L
I
K
V
R
N
R
H
H
N
V
V
P
T
M
A
Q
G
I
I
E
Y
K
D
A
C
T
V
D
P
V
T
N
Q
N
L
-
Q
Y
-
F
L
D
R
F
Y
M
N
R
I
S
T
R
M
L
-
M
N
Q
H
I
L
I
F
S
D
---
S
Q
T
G
----
N
PSH
I
G
S
I
D
P
N
C
-------
D
V
V
A
V
V
Q
D
A
F
E
C
S
R
M
L
-
C
D
Q
Y
YL
S
S
P
E
L
K
L
T
Q
--
V
N
--
G
-----
K
--
F
P
D
-
Q
P
I
--
H
---------
I
V
Y
V
P
S
H
L
H
H
M
L
F
E
L
F
K
N
A
M
R
A
T
V
E
H
-------
Q
E
NQP
S
L
T
P
-------
I
E
V
I
V
V
L
G
K
E
D
L
T
I
K
I
S
D
R
G
G
G
V
P
L
R
I
I
D
R
L
F
S
Y
T
Y
S
T
A
P
TP--------
N
A
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
-
Y
F
Q
G
D
L
N
L
Y
S
L
S
G
Y
G
T
D
A
I
I
Y
L
--
K
A
L
S
S
E
S
I
E
K
---------
6
PsiBlast_PDB
58.91
26%
-67
- C1 -
3A0R
1
?
A:
[139-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
---
K
H
-----
L
D
D
P
E
T
L
K
K
-
Y
I
N
I
I
T
N
E
--
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
RV
L
E
F
T
----
E
---
F
N
L
N
E
----------
L
I
R
E
V
Y
V
L
F
E
E
K
I
--
R
-
K
M
N
I
----------
D
--
F
C
--
F
-----
E
--
T
D
N
-
E
D
L
--
R
---------
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
-------
G
-------
K
-------
I
K
I
T
S
E
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
--------------
T
------
L
G
L
S
I
C
R
K
I
I
E
-
D
E
H
G
G
K
I
W
T
E
N
R
E
N
G
V
V
F
I
F
E
I
--
P
K
T
P
---------------
25
HHSearch
56.87
24%
-64
- C1 -
3A0R
1
?
A:
[129-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
D
-------
D
P
E
T
L
-
K
K
-
Y
I
N
I
I
T
N
E
--
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
---
E
R
-----------
V
L
E
F
T
E
F
-------
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
-
I
R
K
M
----------
N
--
I
D
--
F
C
F
---
E
--
T
D
N
-
E
D
L
--
R
---------
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
-------
G
-------
K
-------
I
K
I
T
S
E
D
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
--------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
--
P
K
T
P
E
--------------
35
HHSearch
56.15
18%
-71
- C1 -
1ID0
2
A:
[3-146]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
-------
P
V
A
P
L
L
D
N
L
T
S
A
L
N
K
V
-
Y
Q
R
K
----------
G
V
N
I
S
--
L
-----
D
--
I
S
P
-
E
-
I
--
S
---------
F
V
G
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
L
E
F
-----------------------
V
E
I
S
A
R
Q
T
D
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
------------
L
R
P
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
-
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
--
G
R
Q
H
---------------