@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0077: (2016-03-11 )
MNEEILREVADIFIGDDRDSIYDYKTGNELVRFFNHYFNKGDIYQAPFPSRWLYVVKHLQTLIQERKINQFFTLILSNHYIKYELKIDEVEAAKQAAKALKLFNKRLNHYGYYITGTNNARYFMDKDEDTESIGYGGYANIYLQKSTGLAVKKLKEEYLTDSSIKSRFKREFDLTKSFDTNPLFINVFEFNESDYSYTMELADETLKDYIESKTISELEKVKIIMKILKAMSQAHSENKIHRDISSKNVLMFRGKVKISDLGLGKNLDEIHSHQTFDTNGVGQYKYCAPEQMYSLKQADKQSDVFSLGRLINFIMTGNVVNNHHLFRGVSDKATNSSKEYRFEDANEMLKMLQRILEYHSSAKHVEKCQEKLKRGVFDDESEEFIMTRSDEQLCQMVLSSNNNEQACLIRYMQKNESSACDLIESINRKYQEFCGRFEDYDPFAKLAYMILCNNFSYRVNETAARVLNYVAWSVNRFSAQDLIKGLINRGVEPLIEEKLKDN
Atome Classification :
(20 SA)
-.........10........20........30........40....-----------....50........60........70........80........90........100.......110.......120.......130------------------.........140---...--.--.-----------.--.-----150.......-160........170.......180.......------.190-..--.---...------...200.-.-.....210.------.------...-----...220..-.....230.......240.......250..----.-.-....260......-.270.......280.......290..--....-.300.......310....--...320--------------...--------------------------.-------------------------.....330.......340...-....350.......360..-.....----------------370.......380....-------...390.......400.......410..---.....420.......430.......440.......450.......460.......470.......480....--...490.......500---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
N
E
E
I
L
R
E
V
A
D
I
FIGDDRDSIYDYKT
G
N
E
L
V
R
F
F
N
H
YFNKGDIYQ-----------APFP
S
R
W
L
Y
V
V
K
H
L
Q
T
L
I
Q
E
R
K
I
N
Q
F
F
T
L
I
LSN
H
Y
I
K
Y
E
L
K
I
D
E
V
E
A
A
K
Q
A
A
K
A
L
K
L
F
N
K
R
LNHY
G
Y
Y
I
TGTNN
A
R
Y
F
MDKDEDT--------------------ESIGYGG
Y
A
N
I
Y
---
L
QK--S--T-----------G--
L
-----
A
V
K
K
L
K
E
E
YL-T-
D
S
S
I
K
S
R
F
K
R
E
FDLTKSFDT-N
P
L
F
I
N
V
F
------
E
F---NE--S---D
Y
S
------
Y
T
M
E
L
A
D
-
E
-
T
L
K
D
Y
I
E
-S------K------
T
I
S
-----
E
L
E
K
V
K
I
I
-
M
K
I
L
K
A
M
S
Q
AHSEN
K
I
H
RDISSK
N
V
L
M
-
F
R----G-
K
-
V
K
I
S
DLGLGK
N
L
D
-
E
I
HSHQTFDTNGVGQYKYC
A
P
E
Q
M
Y
S
--
L
K
Q
A-DKQ
S
D
V
F
S
L
G
R
L
I
N
F
I
MT--GNVV----------------NN
H
--------------------------
H
-------------------------
L
FRGVSDKATNSSKEYRFE
D
A
-
N
E
M
L
K
M
L
Q
R
I
L
E
Y
HSS
A
K
H
-
V
E
K
C
Q
----------------
E
K
L
KRGVFDDESE
E
F
I
M
-------TR
S
D
E
Q
L
C
Q
M
V
L
SSNNN
E
Q
A
C
L
I
R
Y
M
QK---NE
S
S
A
C
D
L
I
E
S
I
N
R
K
Y
Q
E
F
CGRFEDY
D
P
F
A
K
L
A
Y
M
I
L
CNNFSYR
V
N
E
T
A
A
R
V
L
N
Y
V
A
W
SVNRF
S
A
Q
D
L
I
K
G
L
--
I
NRG
V
E
P
L
I
E
E
K
LKDN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
76.20
16%
-56
- C1 -
4BTF
2
MLKL_MOUSE
A:
[7-460]
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
E
Q
C
E
K
M
K
-
Y
C
R
K
Q
C
Q
R
L
G
N
R
V
H
G
L
L
Q
P
L
Q
R
L
Q
A
Q
GKKNLP
D
D
I
T
A
A
L
G
R
F
D
E
V
L
K
E
A
N
Q
Q
I
E
K
F
I
L
F
H
E
V
N
E
K
L
R
D
V
W
E
E
L
L
L
L
L
Q
V
P
A
S
W
Q
Q
E
D
R
Q
D
A
E
E
D
G
N
E
N
M
K
V
I
L
M
Q
L
Q
I
S
V
E
E
I
N
K
T
L
K
Q
C
SIPQD
L
Q
I
K
EIPKEHLGPP
W
T
K
L
K
T
S
K
M
S
T
I
Y
---
R
G
E
Y
H
R
--
S
-----------
P
--
V
-----
T
I
K
V
F
N
N
P
Q
A
-
E
S
V
G
I
V
R
F
T
F
N
D
E
I
K
T
M
K
K
F
D
--
S
P
N
I
L
R
I
F
G
I
C
I
D
Q
T
V
---
K
P
--
P
---
E
F
S
------
I
V
M
E
Y
C
E
-
L
G
T
L
R
E
L
L
D
R
E
------
K
------
D
L
T
-----
M
S
V
R
S
L
L
V
-
L
R
A
A
R
G
L
Y
R
L
H
H
S
E
T
L
H
R
N
I
S
S
S
S
F
L
V
-
A
G
----
G
Y
Q
-
V
K
L
A
G
F
E
L
S
K
T
Q
N
-
S
I
S
R
T
A
-------
S
S
T
I
Y
V
S
P
E
R
L
K
N
--
P
F
C
L
Y
D
I
K
A
E
I
Y
S
F
G
I
V
L
W
E
I
A
T
--
G
K
I
P
----------------
F
E
G
--------------------------
C
------------------------------------------------------------------------------------------------------------------
D
S
K
K
I
R
E
L
V
A
E
D
K
K
Q
E
-------------------
P
V
G
Q
D
C
P
E
L
L
R
E
I
I
N
E
C
R
A
H
E
P
S
Q
-------------------------------
R
P
S
V
D
G
I
L
E
R
L
--
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
75.05
14%
-38
- C1 -
2PZI
7
PKNG_MYCTU
A:
[1-677]
----------
G
S
H
M
L
G
G
G
L
V
E
I
P
R
A
P
D
I
D
P
L
E
A
L
M
T
N
--------------------
P
V
V
P
E
S
K
R
F
C
W
N
C
G
R
P
V
G
R
S
G
A
S
E
G
W
C
P
------------
Y
C
G
S
P
Y
S
F
L
P
Q
L
N
P
G
D
I
V
A
G
Q
-----
Y
E
V
K
G
-----------------------------------
C
I
A
H
G
G
L
G
W
I
Y
---
L
A
L
--
D
--
R
-----------
N
--
V
NGR
P
V
V
L
K
G
L
V
H
S
---
G
-
D
A
E
A
Q
A
M
A
M
A
E
R
Q
F
L
A
E
V
V
--
H
P
S
I
V
Q
I
F
------
N
F
---
V
E
--
H
T
D
R
H
G
D
------
P
V
G
Y
I
V
M
-
E
-
Y
V
G
G
Q
S
L
-
K
------
Q
------
K
L
P
-----
V
A
E
A
I
A
Y
L
-
L
E
I
L
P
A
L
S
Y
L
H
S
I
G
L
V
Y
N
D
L
K
P
E
N
I
M
L
-
T
E
----
E
-
Q
-
L
K
L
I
D
L
G
A
V
S
R
I
--------
N
S
F
G
Y
L
Y
G
T
P
G
F
Q
A
P
E
I
V
R
T
----
G
P
-
T
V
A
T
D
I
Y
T
V
G
R
T
L
A
A
L
T
L
--
D
L
P
T
R
NG
R
Y
V
D
G
LPEDD
P
V
L
K
T
Y
--------------------------
D
-------------------------
S
Y
G
R
L
L
R
R
A
I
D
P
D
P
R
Q
R
F
T
T
A
-
E
E
M
S
A
Q
L
T
G
V
L
R
E
V
V
A
Q
D
T
-
G
V
P
R
P
G
L
S
TIFSPSRSTFGVD
L
L
V
A
H
T
D
V
Y
L
D
G
Q
V
H
A
E
-------
K
L
T
A
N
E
I
V
T
A
L
S
V
P
L
V
D
P
T
D
V
A
A
S
V
L
Q
A
---
T
V
L
S
Q
P
V
Q
T
L
D
S
L
R
A
A
R
H
-----
G
D
F
S
E
S
V
E
L
P
L
M
E
V
R
A
L
L
D
L
G
D
V
A
K
A
T
R
K
L
D
D
L
A
E
R
V
G
W
R
W
R
L
V
W
Y
R
A
V
A
E
L
L
T
G
D
Y
D
S
A
T
K
H
F
T
E
V
L
D
T
F
PGE
L
A
P
K
L
A
L
A
A
T
A
E
L
A
GNTDEHK
F
Y
Q
T
V
W
S
T
NDGV
I
S
A
A
F
G
L
A
R
A
R
S
A
E
GD
R
V
G
A
V
R
T
L
D
E
VPPTSRH
F
T
T
A
R
L
T
S
A
V
T
L
LVT
E
E
Q
I
R
D
A
A
R
R
V
E
A
LPPTEPR
V
L
Q
I
R
A
L
V
L
G
G
A
L
D
W
L
K
D
N
KASTNHILGFPFT
S
H
G
L
R
L
G
V
E
A
S
L
R
S
L
A
R
V
APT
Q
R
H
R
Y
T
L
V
D
M
A
N
K
V
RP
26
HHSearch
74.67
24%
-45
- C1 -
3H4J
-
SNF1_SCHPO
B:
[31-282]
---------------------------------------------------------------------------------------------------------------------------------------
I
G
P
Y
I
I
R
--------------------
E
T
L
G
E
G
S
F
G
K
V
K
---
L
A
T
--
H
YK
T
Q
Q
---------
K
--
V
-----
A
L
K
F
I
S
R
Q
L
L
-
K
-
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
--
H
P
H
I
I
K
L
Y
------
D
V
---
I
T
T
P
T
---
D
I
V
------
M
V
I
E
Y
A
G
-
G
-
E
L
F
D
Y
I
V
-
E
K
-----
K
------
R
M
T
-----
E
D
E
G
R
R
F
F
-
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
D
D
N---
L
-
N
-
V
K
I
A
D
F
G
L
S
N
I
M
T
-
D
G
----
N
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
--
K
L
Y
A
-
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
--
G
R
L
P
----------------
F
D
D
EFIPNLFKKVN
S
C
V
Y
V
M
P
D
F
L
S----
P
-------------------------
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
-
T
I
-
Q
E
I
R
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
73.46
24%
-42
- C1 -
2PSQ
2
FGFR2_HUMAN
A:
[81-365]
----------------------------------------------------------------------------------------------------------------------------------------
D
K
L
T
L
G
--------------------
K
P
L
G
E
G
C
F
G
Q
V
V
---
M
A
E
--
A
--
V
GIDKDKPK
E
A
V
T
--
V
-----
A
V
K
M
L
K
D
D
A
----
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
------
G
A
---
C
T
QD
G
---
P
L
Y
------
V
I
V
E
Y
A
S
K
G
-
N
L
R
E
Y
L
R
-
A
------
R
RPPPEE
Q
M
T
-----
F
K
D
L
V
S
C
T
-
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-
T
E
N---
N
-
V
-
M
K
I
A
D
F
G
L
A
R
D
I
N
-
N
I
D
Y
-
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
---
R
V
Y
-
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
----------------
Y
P
G
IPVEE
L
F
K
L
L
K
E
G
H
R
M
D
K
PANCT---
N
-------------------------
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
-
T
F
-
K
Q
L
V
E
D
L
D
R
I
L
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.82
25%
-36
- C1 -
3ORK
3
?
A:
[9-215]
-------------------------------------------------------------------------------------------------------------------------------------
H
L
S
D
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
RDH
R
-------
D
--
V
-----
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
D
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
-------------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
69.37
22%
-41
- C1 -
1FGK
-
FGFR1_HUMAN
A:
[464-762]
-----------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
-------------------------
Q
V
V
L
A
E
A
I
GLP-
N
R
--
V
--
T
-----------
K
--
V
-----
A
V
K
M
L
K
S
D
---
A
-
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
------
G
A
CTQ
D
G
--
P
---
L
Y
V
------
I
V
E
Y
A
S
K
-
G
-
N
L
R
E
Y
L
Q
-
A
R
RPPEE-------
Q
L
S
-----
S
K
D
L
V
S
C
A
-
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-
T
E
----
D
-
N
V
M
K
I
A
D
F
G
L
A
--
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
---
R
I
Y
-
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
----------------
P
G
V
--------------------------
P
-------------------------
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----------------
E
D
L
D
R
I
V
A
L
T
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
68.81
23%
-56
- C1 -
3UC3
3
SRK2I_ARATH
A:
[19-293]
---------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
D
F
V
--------------------
K
D
I
G
S
G
N
F
G
V
A
R
---
L
M
R
--
D
KL
T
-----------
K
E
L
V
-----
A
V
K
Y
I
E
R
G
A
A
------
I
D
E
N
V
Q
R
E
I
I
N
H
R
S
L
R
--
H
P
N
I
V
R
F
K
------
E
V
---
I
L
T
P
T
---
H
L
A
------
I
I
M
E
Y
A
S
G
G
-
E
L
Y
E
R
I
C
-
N
A
-----
G
------
R
F
S
-----
E
D
E
A
R
F
F
F
-
Q
Q
L
L
S
G
V
S
Y
C
H
S
M
Q
I
C
H
R
D
L
K
L
E
N
T
L
L
-
D
G
SPA-
P
-
R
-
L
K
I
C
D
F
G
Y
S
--------------------
P
A
Y
I
A
P
E
V
L
L
R
--
Q
E
Y
D
-
G
K
I
A
D
V
W
S
C
G
V
T
L
Y
V
M
L
V
--
G
A
Y
P
----------------
F
E
-PRD
Y
R
K
T
I
Q
R
I
L
S
VKYSIPDD
I
R
I
S
-
P
-------------------------
E
C
C
H
L
I
S
R
I
F
V
A
D
P
A
T
R
I
-
S
I
-
P
E
I
K
T
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.91
25%
-32
- C1 -
3ORO
2
?
A:
[12-215]
----------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
RDH
R
-------
D
--
V
-----
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
D
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
R
A
I
A
---------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.72
25%
-42
- C1 -
3ORM
2
?
A:
[13-215]
-----------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
-----------
R
--
L
H
R
D
V
-
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
A
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
R
A
I
A
---------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
67.45
23%
-35
- C1 -
3FE3
-
MARK3_HUMAN
A:
[52-304]
--------------------------------------------------------------------------------------------------------------------------------------
H
I
G
N
Y
R
L
L
--------------------
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
--
H
IL
T
-----------
G
R
E
V
-----
A
I
K
I
I
D
K
T
Q
L
-
N
--
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
--
H
P
N
I
V
K
L
F
------
E
V
---
I
E
T
E
K
---
T
L
Y
------
L
I
M
E
Y
A
S
G
G
-
E
V
F
D
Y
L
V
-
A
H-----
G
------
R
M
K
-----
E
K
E
A
R
S
K
F
-
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
-
D
A
D---
M
-
N
-
I
K
I
A
D
F
G
F
S
N
E
F
T
-
V
G
----
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
--
G
S
L
P
----------------
F
D
G
QN
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
FYMS----
T
-------------------------
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-
T
L
-
E
Q
I
M
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
67.38
19%
-43
- C1 -
2ZMD
2
A:
[56-321]
----------------------------------------------------------------------------------------------------------------------------------------
R
I
Y
S
I
L
--------------------
K
Q
I
G
S
G
G
S
S
K
V
F
---
Q
V
L
--
N
--
E
KK
Q
--------
I
--
Y
-----
A
I
K
Y
V
N
L
E
E
A
-
D
--
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
------
D
Y
---
E
I
T
D
Q
---
Y
I
Y
------
M
V
M
E
C
G
N
-
I
-
D
L
N
S
W
L
K
-
K
K-----
K
------
S
I
D
-----
P
W
E
R
K
S
Y
W
-
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
-
V
D
----
G
-
M
-
L
K
L
I
D
F
G
I
A
N
Q
M
-----------
D
S
Q
V
G
A
V
N
Y
M
P
P
E
A
I
K
D
M----
I
-
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
--
G
K
T
P
----------------
F
Q
Q
IIN
Q
I
S
K
L
H
A
I
I
DPN
H
E
I
E
F
P
D
IPE-
K
-------------------------
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
-
S
I
-
P
E
L
L
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.01
25%
-36
- C1 -
3F61
5
PKNB_MYCTU
A:
[9-215]
-------------------------------------------------------------------------------------------------------------------------------------
H
L
S
D
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
RDH
R
-------
D
--
V
-----
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
D
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
--------------------
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.12
27%
-44
- C1 -
4KRC
2
PHO85_YEAST
A:
[11-215]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
-
L
N
K
--
T
--
T
-----------
G
--
V
-----
Y
V
A
-
L
K
E
V
K
L
D
S
-
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
-
E
N
I
-
V
R
L
Y
------
D
V
I
H
-
T
E
--
N
---
K
L
T
------
L
V
F
E
F
M
D
-
N
-
D
L
K
K
Y
M
D
-
S
------
R
---------TPRGL
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
----
G
-
Q
-
L
K
L
G
D
F
G
L
A
R
A
F
G
-
I
--
P
V
N
T
F
S
S
E
V
V
T
L
W
-
Y
R
A
P
D
V
L
M
G
--
S
R
T
Y
-
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
--
G
K
P
------------------------------------------------------------------------
L
F
P
G
T
N
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.12
27%
-35
- C1 -
2PK9
1
PHO85_YEAST
A:
[11-215]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
-
L
N
K
--
T
--
T
-----------
G
--
V
-----
Y
V
A
-
L
K
E
V
K
L
-
S
-
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
-
E
N
I
-
V
R
L
Y
------
D
V
IH-----
N
---
K
L
T
------
L
V
F
E
F
M
D
-
N
-
D
L
K
K
Y
M
D
-
S
------
R
------
T
--RGL--
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
----
G
-
Q
-
L
K
L
G
D
F
G
L
A
R
A
F
G
-
I
--
P
V
N
T
F
S
S
E
V
V
T
L
W
-
Y
R
A
P
D
V
L
M
G
--
S
R
T
Y
-
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
--
G
K
P
------------------------------------------------------------------------
L
F
P
G
T
N
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.66
25%
-37
- C1 -
3ORT
2
?
A:
[9-215]
-------------------------------------------------------------------------------------------------------------------------------------
H
L
S
D
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
RDH
R
-------
D
--
V
-----
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
D
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
R
-------------------
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.65
19%
-36
- C1 -
3DBQ
-
TTK_HUMAN
A:
[523-788]
----------------------------------------------------------------------------------------------------------------------------------------
R
I
Y
S
I
L
--------------------
K
Q
I
G
S
G
G
S
S
K
V
F
---
Q
V
L
--
N
--
E
KK
Q
--------
I
--
Y
-----
A
I
K
Y
V
N
L
E
E
A
-
D
--
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
------
D
Y
---
E
I
T
D
Q
---
Y
I
Y
------
M
V
M
E
C
G
N
-
I
-
D
L
N
S
W
L
K
-
K
K-----
K
------
S
I
D
-----
P
W
E
R
K
S
Y
W
-
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
-
V
D
----
G
-
M
-
L
K
L
I
D
F
G
I
A
N
Q
M
--------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
MS---
I
-
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
--
G
K
T
P
----------------
F
Q
Q
IIN
Q
I
S
K
L
H
A
I
I
DPNH
E
I
E
F
P
DIPE-
K
-------------------------
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
-
S
I
-
P
E
L
L
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
64.37
19%
-33
- C1 -
3TKI
2
CHK1_HUMAN
A:
[6-262]
---------------------------------------------------------------------------------------------------------------------------------------
V
E
D
W
D
L
V
--------------------
Q
T
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
--
N
RV
T
-----------
E
E
A
V
-----
A
V
K
I
V
D
M
K
-----------
N
I
K
K
E
I
C
I
N
K
M
L
N
--
H
E
N
V
V
K
F
Y
------
G
H
---
R
R
EG
N
---
I
Q
Y
------
L
F
L
E
Y
C
S
G
G
-
E
L
F
D
R
I
E
-
P
D-----
I
------
G
M
P
-----
E
P
D
A
Q
R
F
F
-
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
-
D
E
R---
D
-
N
-
L
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
-
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
-
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
--
G
E
L
P
----------------
W
D
Q
--------------------------
P
SDSC
Q
E
Y
S
D
W
K
E
KKTYLNPWKKID
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-
T
I
-
P
D
I
K
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
64.20
19%
-27
- C1 -
3H4J
-
SNF1_SCHPO
B:
[27-356]
---------------------------------------------------------------------------------------------------------------------------------
S
K
R
H
I
G
P
Y
I
I
R
E
T
--------------------
L
G
E
G
S
F
G
K
V
K
L
A
---
T
H
Y
--
K
--
T
-----------
Q
QK
V
-----
A
L
K
F
I
S
R
Q
L
L
-
K
-
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
-
R
-
H
P
H
I
I
K
L
Y
------
D
V
---
I
T
--
T
PT-
D
I
V
------
M
V
I
E
Y
A
G
-
G
-
E
L
F
D
Y
I
V
-
E
------
K
K-----
R
M
T
-----
E
D
E
G
R
R
F
F
-
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
D
N
----
L
-
N
-
V
K
I
A
D
F
G
L
S
N
I
M
T
-
D
G
N
F
L
K
T
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
--
K
L
Y
A
-
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
--
G
R
L
P
----------------
F
D
D
--------------------------
E
-------------------------
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
F
L
S
-
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
---
I
T
I
Q
----------------
E
I
R
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
PMEEVQG
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
A
L
R
S
DEN
N
E
V
K
E
A
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
63.65
20%
-29
- C1 -
2BDW
-
KCC2D_CAEEL
A:
[9-268]
--------------------------------------------------------------------------------------------------------------------------------------
F
S
D
N
Y
D
V
K
--------------------
E
E
L
G
K
G
A
F
S
V
V
R
---
R
C
V
--
H
--
K
TTG
L
-------
E
--
F
-----
A
A
K
I
I
N
T
K
K
L
-
S
--
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
--
H
P
N
I
V
R
L
H
------
D
S
---
I
Q
E
E
S
---
F
H
Y
------
L
V
F
D
L
V
T
G
G
-
E
L
F
E
D
I
V
-
A
R-----
E
------
F
Y
S
-----
E
A
D
A
S
H
C
I
-
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
-
A
S
KAKG
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
V
N
-
D
S
----
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
---
D
P
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
--
G
Y
P
P
----------------
F
W
D
ED
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
PEWDTVT
P
-------------------------
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-
T
A
-
D
Q
A
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.01
25%
-31
- C1 -
3ORP
1
?
A:
[9-215]
-------------------------------------------------------------------------------------------------------------------------------------
H
L
S
D
R
Y
E
L
G
--------------------
E
I
L
G
F
G
G
M
S
E
V
H
---
L
A
R
--
D
--
L
RDH
R
-------
D
--
V
-----
A
V
K
V
L
R
A
D
L
A
-
R
-
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
--
H
P
A
I
V
A
V
Y
------
D
T
---
G
E
--
A
---
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
-
G
V
T
L
R
D
I
V
H
-
T
------
E
G-----
P
M
T
-----
P
K
R
A
I
E
V
I
-
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
----
N
-
A
-
V
K
V
M
D
F
G
I
A
-----------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
---
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
--
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------