@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0084: (2016-03-12 )
MNKHYQIVIIGGGTAGVTVASRLLRKNQNLKEKIAIIDPADHHYYQPLWTLVGAGVSSLKSSRKDMESVIPEGANWIKQAVSSFQPENNSVILGDNTVVYYDFLVVAPGLQINWSSIKGLKENIGKNGVCSNYSPDYVNETWNQISNFKQGNAIFTHPNTPIKCGGAPMKIMYLAEDYFRKHKIRSNANVIYATPKDALFDVGKYNKELERIVEERNITVNYNYNLVEIDGDKKVATFEHIKAYDRKTISYDMLHVTPPMGPLDVVKESTLSDSEGWVDVNPTTLQHKSYSNVFALGDASNVPTSKTGAAIRKQAPIVANNLLQVMNNQMLTHHYDGYTSCPIVTGYNRLILAEFDYNKNTKETMPFNQAKERRSMYIFKKDLLPKMYWYGMLKGLI
Atome Classification :
(20 SA)
-------.........10........20........-30.......-..40..-..-.-.-.-.50...-.-....------------.--60..-.---------......70-.---....-..-.-80........90..--------------------.-----.-----.--...100.......110...-.-...120...--....130.......140.......150.-....------------------..-------------160----......--------..170....--...180-----......-..190.......200----.---.-......210--.......220----.......230.---.---------------------.---....240-.....--..250.......260---..-.-.-....-----.--270..-.-......280.......--290.......300-.----------.---------.--------....310.......320.......330...-....340----------.......-.---.350.......360.......370.......380----.........390.....------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MNK
H
Y
Q
I
V
I
IGGGT
A
G
V
T
V
A
S
R
L
L
R
KNQ
N
-
L
-
K
E
K
I
A
I
I-DPADH
H
-
Y
Y
-
Q
-
P
-
L
-
W
T
-
L
V
G
-
A
-
G
V
S
S
------------
L
--
K
-
S
S
-
R
---------
K
D
M
E
S
VIP-E---
G
A
N
W
-
I
K
-
Q
-
A
V
S
SFQPENN
S
V
I
L--------------------G-----D-----
N
--
T
V
V
Y
Y
D
F
L
V
VAPG
L
Q
I
N
W
S
-
S
-
I
K
G
L
K
E
N
IG--KNGVCSNYS
P
D
Y
V
N
E
T
W
N
Q
I
SNFKQG
N
A
-
I
F
TH------------------PN-------------T
P
-----
I
KCGGA--------
P
M
K
I
M
Y
L
A
E
--
D
Y
F
R
K
------HKIRSN-A
N
V
I
Y
AT
P
K
D
A
L
F
D
-----
V
---
G
-
K
Y
N
K
E
L
E
R
I
--
V
E
ER
N
I
T
V
N
Y
----
N
Y
N
L
V
E
IDGDK---
K
---------------------
V
---
A
T
F
E
H
I
K
-
A
YDRK--T
I
S
Y
D
M
L
H
VTPPM-----
G
P
-
L
-
D
-
V
V
K
E-----S--T--LS-D-SE
G
W
V
DVNP
T
T
L
QHKS--YS
N
V
F
ALGDASNV-P----------T---------S--------KT
G
A
A
I
RKQA
P
I
V
A
N
N
L
L
Q
V
MN
N
Q
M
L
T
HHY-DGYTS------------C
P
I
VTGY-
N
---
R
L
I
L
A
E
FDYNKNTKETMP
F
N
Q
A
K
E
R
R
S
M
Y
I
F
K
------
K
DL
L
P
K
M
Y
W
Y
G
M
L
K
GLI------------------------------
58
Fugue
90.14
22%
-90
- C2 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
-
G
-
S
-
K
A
D
V
K
V
I
-
N
K
S
R
F
S
-
Y
F
-
R
-
P
-
A
-
L
P
-
H
V
A
-
I
-
G
V
R
D
------------
V
--
D
-
E
L
-
K
---------
V
D
L
S
E
A
L
P
-
E
K
--
G
I
Q
F
-
Q
E
-
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
T
K
PD----------------
G
-----
S
-----
M
--
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
-
L
-
V
K
G
W
D
K
Y
-------
G
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
Q
G
G
N
I
-
A
I
G
S
G
P
FYQGHNPKPKVPENF
V
P
N
-------------
A
D
-----
S
A
C
E
G
P
--------
V
F
E
M
S
L
M
L
H
--
G
Y
F
K
K
------
K
G
M
L
D
K
-
V
H
V
T
V
F
S
P
G
E
Y
L
S
D
-----
L
S--
P
-
N
S
R
K
A
V
A
S
I
--
Y
N
Q
L
G
I
K
L
V
H
----
N
F
K
I
K
E
I
R
E
H
E
---
I
---------------------
V
---
D
E
--------
K
G
N
--
T
I
P
A
D
I
T
I
L
L
P
P
Y
-----
T
G
-
N
-
P
-
A
L
K
N
-----
S
TP
D
--
L
V
-
D
-
D
G
G
F
I
P
T
D
L
N
-
M
V
S
I
K
--
Y
D
N
V
Y
A
V
G
D
A
N
S
M
-
T
----------
V
---------
P
--------
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
N
R
L
G
V
P
T
K
V
D
K
Y
-
Y
P
T
I
V
------------
C
V
A
D
N
P
Y
-
E
----------------------------------------------------------------------------------------
33
HHSearch
88.04
20%
-75
- C2 -
3SX6
9
SQRD_ACIF2
A:
[1-404]
-------
M
R
G
S
A
H
V
V
I
L
G
A
G
T
G
G
M
P
A
A
Y
E
M
K
--
E
A
L
G
S
-
G
H
E
V
T
L
I
-
S
A
N
D
Y
F
-
Q
F
-
V
-
P
-
S
-
N
P
-
W
V
G
-
V
-
G
W
K
E
------------
R
--
D
-
D
I
-
A
---------
F
P
I
R
H
Y
V
E
R
K
---
G
I
H
F
-
I
A
-
Q
-
S
A
E
Q
I
D
A
E
A
Q
N
I
T
L
--------------------
A
-----
D
-----
G
--
N
T
V
H
Y
D
Y
L
M
I
A
T
G
P
K
L
A
F
E
-
N
-
V
P
G
S
D
P
H
E
----
G
P
V
Q
S
I
C
T
V
D
H
A
E
R
A
F
A
E
Y
Q
A
L
L
R
--------------------------
E
P
-------------
G
P
-----
I
V
I
G
A
M
AGASCF
G
P
A
Y
E
Y
A
M
I
V
A
--
S
D
L
K
K
------
R
G
M
R
D
K
I
P
S
F
T
F
I
T
S
E
P
Y
I
G
H
LGIQG
V
---
G
-
D
S
K
G
I
L
T
K
G
--
L
K
E
E
G
I
E
A
Y
T
----
N
C
K
V
T
K
V
E
D
N
K
---
M
---------------------
Y
---
V
T
Q
V
D
----
E
K
G
E
--
T
I
K
E
M
V
L
P
V
K
F
G
M
M
I
P
A
F
K
G
-
V
-
P
-
A
V
A
G
V----
E
--
G
--
L
C
-
N
-
P
G
G
F
V
L
V
D
E
-
H
Q
R
S
K
K
--
Y
A
N
I
F
A
A
G
I
A
I
A
I
-
P
P
VETTPV
P
T
G
A
---------
P
--------
K
T
G
Y
M
I
E
S
M
V
S
A
A
V
H
N
I
K
A
D
L
E
G
R
K
G
E
Q
T
M
G
T
W
N
A
V
------------
A
F
A
D
M
G
D
-
R
---
G
A
A
F
I
A
L
P
Q
L
K
P
R
K
V
D
----
V
F
A
Y
G
R
W
V
H
L
A
K
------
V
A
F
E
K
--
Y
F
I
R
K
-----------------------------------
35
HHSearch
87.74
21%
-95
- C2 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
--
R
L
V
-
G
S
K
A
D
V
K
V
I
-
N
K
S
R
F
S
-
Y
F
-
R
-
P
-
A
-
L
P
-
H
V
A
-
I
-
G
V
R
D
------------
V
--
D
-
E
L
-
K
---------
V
D
L
S
E
A
L
P
E
K
---
G
I
Q
F
-
Q
E
-
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
--------------------
T
K
P---
D
-----
G
S
M
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
-
L
-
V
K
G
W
D
K
Y
-------
G
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
Q
G
G
N
I
-
A
I
G
S
------------------
G
P
FYQGHNPKPKVPE
N
F
V
P
N
A
D
S
A
C
E
G
P
--------
V
F
E
M
S
L
M
L
H
--
G
Y
F
K
K
------
K
G
M
L
D
K
-
V
H
V
T
V
F
S
P
G
E
Y
L
S
D
L----
S
---
P
-
N
S
R
K
A
V
A
S
I
--
Y
N
Q
L
G
I
K
L
V
H
----
N
F
K
I
K
E
I
R
E
H
--------------------------
E
---
I
V
D
E
K
------
G
N
--
T
I
P
A
D
I
T
I
L
L
P
P
Y
-----
T
G
-
N
-
P
-
A
L
K
N
-----
S
--
T
PD
L
V
-
D
-
D
G
G
F
I
P
T
D
L
-
N
M
V
S
I
K
--
Y
D
N
V
Y
A
V
G
D
A
N
S
M
-
T
----------
V
---------
P
--------
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
N
R
L
G
V
P
T
K
V
D
K
Y
-
Y
P
T
I
V
------------
C
V
A
D
N
P
Y
E-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.63
23%
-82
- C2 -
3H8L
6
SQRD_ACIAM
A:
[4-331]
--------------
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
-
K
A
D
V
K
V
I
-
N
K
S
R
F
S
-
Y
F
-
R
-
P
-
A
-
L
P
-
H
V
A
-
I
-
G
V
R
D
------------
V
--
D
-
E
L
-
K
---------
V
D
L
S
E
A
L
P
-
E
K
--
G
I
Q
F
-
Q
E
-
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
T
K
PD----------------
G
-----
S
-----
M
--
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
-
L
-
V
K
G
W
-
D
K
Y
G
--
Y
S
-
V
C
---
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
Q
G
G
N
I
-
A
I
G
S
G
P
FYQGHNPKPKVPENF
V
P
N
-------------
A
D
-----
S
A
C
E
G
P
--------
V
F
E
M
S
L
M
L
H
--
G
Y
F
K
K
------
K
G
M
L
D
K
-
V
H
V
T
V
F
S
P
G
E
Y
L
S
D
-----
L
---
S
P
N
S
R
K
A
V
A
S
I
--
Y
N
Q
L
G
I
K
L
V
H
----
N
F
K
I
K
E
I
R
-----------------------------------
E
H
-
E
-
I
V
D
E
K
G
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
-----
T
G
-
N
-
P
-
A
L
K
N
-----
S
--
T
PD
L
V
-
D
-
D
G
G
F
I
---
P
T
D
L
N
M
V
S
IK
Y
D
N
V
Y
A
V
G
D
A
N
S
M
-
T
----------
V
---------
P
--------
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
--------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.34
23%
-83
- C2 -
3H8I
6
SQRD_ACIAM
A:
[4-331]
--------------
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
-
S
-
K
A
D
V
K
V
I
-
N
K
S
R
F
S
-
Y
F
-
R
-
P
-
A
-
L
P
-
H
V
A
-
I
-
G
V
R
D
------------
V
--
D
-
E
L
-
K
---------
V
D
L
S
E
A
L
P
-
E
K
--
G
I
Q
F
-
Q
E
-
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
T
K
PD----------------
G
-----
S
-----
M
--
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
-
L
-
V
K
G
W
-
D
K
Y
G
--
Y
S
-
V
C
---
E
P
E
F
A
T
K
L
R
E
K
L
E
S
F
Q
G
G
N
I
-
A
I
G
S
G
P
FYQGHNPKPKVPENF
V
P
N
-------------
A
D
-----
S
A
C
E
G
P
--------
V
F
E
M
S
L
M
L
H
--
G
Y
F
K
K
------
K
G
M
L
D
K
-
V
H
V
T
V
F
S
P
G
E
Y
L
S
D
-----
L
---
S
P
N
S
R
K
A
V
A
S
I
--
Y
N
Q
L
G
I
K
L
V
H
----
N
F
K
I
K
E
I
R
-----------------------------------
E
H
-
E
-
I
V
D
E
K
G
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
-----
T
G
-
N
-
P
-
A
L
K
N
-----
S
--
T
PD
L
V
-
D
-
D
G
G
F
I
---
P
T
D
L
N
M
V
S
IK
Y
D
N
V
Y
A
V
G
D
A
N
S
M
-
T
----------
V
---------
P
--------
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
--------------------------------------------------------------------------------------------------------------------------------
64
Fugue
79.22
16%
-73
- C2 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
H
S
D
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
----
D
T
-
K
-
K
Y
N
V
S
I
I
-
S
P
R
S
Y
F
-
L
F
-
T
-
P
-
L
-
L
P
-
S
A
P
-
V
-
G
T
V
D
------------
E
--
K
-
S
I
-
I
---------
E
P
I
V
N
F
A
L
-
K
KK
G
N
V
T
Y
-
Y
E
-
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQ
A
-----
E
-----
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
F
-
G
-
I
P
G
V
T
D
Y
G
H
FL
K
E
I
P
N
S
L
E
I
R
R
T
F
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
-
E
R
R
R
------------------
L
L
-------------
S
I
-----
V
V
V
G
G
G
--------
P
T
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DLRKFL
P
A
L
A
E
E
-
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-----
M
FE-
K
-
K
L
S
S
Y
A
Q
S
H
--
L
E
N
T
S
I
K
V
H
L
----
R
T
A
V
A
K
V
E
E
K
Q
---
L
---------------------
L
---
A
K
T
K
H
E
D
G
K
I
T
E
E
--
T
I
P
Y
G
T
L
I
W
A
T
G
N
-----
K
A
-
R
-
P
-
V
I
T
D
L
F
K
K
I
P
--
E
--
Q
N
-
S
-
S
K
R
G
L
A
V
N
D
F
-
L
Q
V
K
G
--
S
N
N
I
F
A
I
G
D
N
A
F
A
-
G
----------
L
---------
P
--------
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
I
D
-
L
L
F
E
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
G
S
-
E
---
R
A
I
A
T
I
R
S
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
ILS
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL-------------------------
49
HHSearch
74.60
19%
-96
- C2 -
3OC4
1
?
A:
[3-314]
-----------
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
--
K
K
Y
-
P
-
Q
A
E
I
S
L
I
-
D
K
Q
A
T
V
-
G
Y
-
L
-
S
-
G
--------------------------------
R
-
Y
---------
I
T
E
E
E
L
R
R
-
Q
---
K
I
Q
L
L
L
N
-
R
-
E
V
V
A
M
D
V
E
N
Q
L
I
A
W
T
R
K-----------------
E
-----
E
-----
Q
--
Q
W
Y
S
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
-
Q
-
I
R
G
S
Q
T
------
E
K
L
L
K
Y
K
F
L
S
----
A
V
P
L
-----------
L
E
N
------------------
S
Q
-------------
T
V
-----
A
V
I
G
A
G
--------
P
I
G
M
E
A
--
I
--
D
F
L
V
K
------
M
K
-----
K
T
V
H
V
F
E
S
L
E
N
L
L
P
-----
K
YFD
K
-
E
M
V
A
E
V
Q
K
S
--
L
E
K
Q
A
V
I
F
H
F
----
E
E
T
V
L
G
I
E
E
T
A
---
N
---------------------
G
---
I
V
L
E
T
-----
S
E
Q
--
E
I
S
C
D
S
G
I
F
A
L
N
L
-----
H
P
-
Q
L
A
-
Y
L
D
K
--------
K
--
I
Q
R
N
-
L
D
Q
T
I
A
V
D
A
-
Y
L
Q
-
T
S
--
V
P
N
V
F
A
I
G
D
C
I
S
V
-
M
----------
N
EPVA
E
T
F
Y
-
A
--------
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
L
E
E
K
-----------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.49
19%
-84
* C2 *
3EF6
9
TODA_PSEP1
A:
[3-311]
-----------
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
--
A
E
G
-
F
-
E
G
R
I
S
L
I
-
G
D
E
P
H
L
-
P
Y
D
R
-
P
-
S
-
L
S
-
K
A
V
-
L
D
G
S
L
E
------------
R
--
P
-
P
I
-
L
---------
A
E
A
D
W
Y
G
E
-
A
---
R
I
D
M
-
L
T
G
P
-
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
--------------------
D
-----
D
-----
G
--
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
-
L
P
G
S
Q
L
------
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
-----------
T
S
------------------
A
T
-------------
R
L
-----
L
I
V
G
G
G
--------
L
I
G
C
E
V
--
A
--
T
T
A
R
K
------
L
G
-----
L
S
V
T
I
L
E
A
G
D
E
L
L
V
-----
R
VLG
R
-
R
I
G
A
W
L
R
G
L
--
L
T
E
L
G
V
Q
V
E
L
----
G
T
G
V
V
G
F
S
G
E
G
---
Q
LE-------------------
Q
---
V
M
A
S
D
------
G
R
--
S
F
V
A
D
S
A
L
I
C
V
G
A
-----
E
P
-
A
D
Q
-
L
A
R
Q
-----
A
--
G
--
L
A
-
C
--
D
R
G
V
I
V
D
H
-
C
G
A
-
T
L
--
A
K
G
V
F
A
V
G
D
V
A
S
W
-
P
----------
L
RA
G
G
R
R
S--
L
--------
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
V
---------------------------------------------------------------------------------------------------------------------------
42
HHSearch
73.86
19%
-86
- C2 -
1XHC
1
?
A:
[9-301]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
--
Q
-----
T
Y
E
V
T
V
I
-
D
K
E
P
V
P
-
Y
Y
S
K
-
P
-
M
-
L
S
-
H
Y
I
-
A
-
G
F
I
P
------------
R
--
N
-
R
L
-
F
---------
P
Y
S
L
D
W
Y
R
K
R
---
G
I
E
I
-
R
L
A
E
-
E
A
K
L
I
D
R
G
R
K
V
V
I
T
--------------------
E
-----------
K
--
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
-
I
K
G
K
E
--------
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
-----------
E
N
------------------
S
G
-------------
E
A
-----
I
I
I
G
G
G
--------
F
I
G
L
E
L
--
A
--
G
N
L
A
E
------
A
G
-----
Y
H
V
K
L
I
H
R
G
A
M
F
L
G
L----
D
---
E
-
E
L
S
N
M
I
K
D
M
--
L
E
E
T
G
V
K
F
F
L
----
N
S
E
L
L
E
A
N
E
E
G
-----------------------------
V
L
-
T
N
------
S
G
--
F
I
E
G
K
V
K
I
C
A
I
G
I
-----
V
P
-
N
V
D
-
L
A
R
R
-----
S
--
G
--
I
H
-
T
-
G
R
G
-
I
L
I
D
D
-
N
F
R
-
T
S
--
A
K
D
V
Y
A
I
G
D
C
A
E
Y
-
S
GI--------
I
---------
A
--------
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
73.82
18%
-79
- C2 -
3CGB
2
?
A:
[37-354]
-----------
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
--
R
N
D
-
E
-
N
A
N
V
V
T
L
-
E
K
G
E
I
Y
S
Y
A
-
Q
-
C
-
G
-
L
P
-
Y
V
I
-
S
-
G
A
I
A
------------
S
T-
E
K
L
I
-
A
---------
R
N
V
K
T
F
R
D
K
Y
---
G
I
D
A
K
V
R
-
H
-
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
--------------------
E
HTKTK
D
-----
V
--
F
E
F
S
Y
D
R
L
L
I
A
T
G
V
R
P
V
M
P
-
E
-
W
E
G
R
D
L
------
Q
G
V
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
E
T
---------
N
K
------------------
V
E
-------------
D
V
-----
T
I
I
G
G
G
--------
A
I
G
L
E
M
--
A
--
E
T
F
V
E
------
L
G
-----
K
K
V
R
M
I
E
R
N
D
H
I
G
T
IY---
D
---
G
-
D
M
A
E
Y
I
Y
K
E
--
A
D
K
H
H
I
E
I
L
T
----
N
E
N
V
K
A
F
K
G
N
E
---
R
---------------------
V
E--
A
V
E
T
D
------
K
G
--
T
Y
K
A
D
L
V
L
V
S
V
G
V
-----
K
P
-
N
T
D
-
F
L
E
G
-----
T
--
N
--
I
R
T
N
-
H
K
G
A
I
E
V
N
A
-
Y
M
Q
-
T
N
--
V
Q
D
V
Y
A
A
G
D
C
A
T
H
-
Y
----------
H
VIKE
I
H
D
H
-
I
--------
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
K
R
----------------------------------------------------------------------------------------------------------------------------
46
HHSearch
73.15
17%
-88
- C2 -
3FG2
2
?
P:
[1-310]
----------
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
--
Q
A
K
-
Y
-
P
G
R
I
A
L
I
-
N
D
E
K
H
L
-
P
Y
-
Q
-
R
-
P
P
L
S
K
A
Y
L
-
K
-
S
G
G
D
------------
P
--
N
-
S
L
-
M
---------
F
R
P
E
K
F
F
Q
D
Q
---
A
I
E
L
-
I
S
-
D
-
R
M
V
S
I
D
R
E
G
R
K
L
L
L
--------------------
A
-----
S
-----
G
--
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
-
V
P
N
A
S
L
------
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
-----------
P
D
------------------
K
K
-------------
H
V
-----
V
V
I
G
A
G
--------
F
I
G
L
E
F
--
A
--
A
T
A
R
A
------
K
G
-----
L
E
V
D
V
V
E
L
A
P
R
V
M
A
RVV--
T
---
P
-
E
I
S
S
Y
F
H
D
R
--
H
S
G
A
G
I
R
M
H
Y
----
G
V
R
A
T
E
I
A
A
E
G
---
D
---------------------
R
VTG
V
V
L
S
D
------
G
N
--
T
L
P
C
D
L
V
V
V
G
V
G
V
-----
I
P
-
N
V
E
-
I
A
A
A
-----
A
--
G
--
L
P
-
T
--
A
A
G
I
I
V
D
Q
-
Q
L
L
-
T
S
--
D
P
H
I
S
A
I
G
D
C
A
L
F
-
E
----------
S
VRFGETMR-
V
--------
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
-----------------------------------------------------------------------------------------------------------------------------
61
Fugue
73.04
15%
-66
- C2 -
1D7Y
1
?
A:
[5-405]
--------
A
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
---
Y
-
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
-
Y
D
-
R
-
P
-
P
-
L
S
-
K
D
F
-
M
-
A
H
G
D
------------
A
--
E
-
K
I
-
R
---------
L
D
C
K
R
A
-
P
-
E
---
V
E
W
L
-
L
G
-
V
-
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
--------------------
S
-----
D
-----
G
--
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
-
T
L
Q
-------------
G
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
-----
L
R
------------------
P
Q
-------------
S
R
-----
L
L
I
V
G
G
--------
G
V
I
G
L
E
L
A
A
--
T
A
R
T
A
-----------
G
-
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
RAA--
P
---
A
-
T
L
A
D
F
V
A
R
Y
--
H
A
A
Q
G
V
D
L
R
F
----
E
R
S
V
T
G
S
V
D
G
----------------------------------
V
V
L
-
L
D
D
G
T
--
R
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
D
-
A
-
L
A
R
A
-----
A
--
G
--
L
A
-
C
-
D
D
G
---
I
F
V
D
A
Y
G
R
T
T
--
C
P
D
V
Y
A
L
G
D
V
T
R
Q
-
R
----------
N
---------
P
--------
L
S
G
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
A
-
P
G
Y
A
E
------------
L
P
W
Y
W
S
D
-
Q
GAL
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
V
R
G
E
V
S
L
D
A
P
K
F
T
L
I
E
L
Q
------
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
GAKPD
R
A
A
L
A
DPAT
D
L
R
K
L
A
A
A
45
HHSearch
72.43
20%
-82
- C2 -
1NHP
3
NAPE_ENTFA
A:
[1-316]
-----------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
--
N
L
H
-
P
-
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
-
S
F
-
L
-
S
-
A
G
M
Q
-
L
Y
L
-
E
-
G
K
V
K
D-----------
V
--
N
-
S
V
-
R
---------
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
-
F
S
N
T
-
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
--------------------
K
-----
D
LVSG
E
E
--
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
-
D
-
I
P
G
K
D
L
------
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
---------
D
P
E
------------------
V
N
-------------
N
V
-----
V
V
I
G
S
G
--------
Y
I
G
I
E
A
--
A
--
E
A
F
A
K
------
A
G
-----
K
K
V
T
V
I
D
I
L
D
R
P
L
G
VYL--
D
---
K
-
E
F
T
D
V
L
T
E
E
--
M
E
A
N
N
I
T
I
A
T
----
G
E
T
V
E
R
Y
E
G
D
G
---
R
V--------------------
Q
---
K
V
V
T
D
------
K
N
--
A
Y
D
A
D
L
V
V
V
A
V
G
V
-----
R
P
-
N
-
T
A
W
L
K
G
--------
T
--
L
E
L
H
-
P
N
G
L
I
K
T
D
E
-
Y
M
R
-
T
S
--
E
P
D
V
F
A
V
G
D
A
T
L
I
-
K
----------
Y
NPAD
T
E
V
N
-
I
--------
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
-----------------------------------------------------------------------------------------------------------------------------
41
HHSearch
72.19
17%
-79
- C2 -
3ICS
2
?
A:
[34-353]
--------
W
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
--
R
L
S
-
E
-
E
D
E
I
I
M
V
-
E
R
G
E
Y
I
-
S
F
-
A
-
N
C
G
-
L
P
-
Y
Y
I
-
G
-
G
V
I
T
------------
E
RQ
K
-
L
L
-
V
---------
Q
T
V
E
R
M
S
K
R
F
---
N
L
D
I
R
V
L
-
S
-
E
V
V
K
I
N
K
E
E
K
T
I
T
I
--------------------
K
-----
N
VTTN
E
T
--
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
-
S
-
I
P
G
I
E
E
A
-----
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
---------
K
K
------------------
P
R
-------------
H
A
-----
T
V
I
G
G
G
--------
F
I
G
V
E
M
--
V
--
E
N
L
R
E
------
R
G
-----
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-----
P
ID-
Y
-
E
M
A
A
Y
V
H
E
H
--
M
K
N
H
D
V
E
L
V
F
----
E
D
G
V
D
A
L
E
E
N
G
---
A
---------------------
V
---
V
R
L
K
S
------
G
S
--
V
I
Q
T
D
M
L
I
L
A
I
G
V
-----
Q
P
-
E
S
S
-
L
A
K
G
-----
A
--
G
--
L
A
L
G
-
V
R
G
T
I
K
V
N
E
-
K
F
Q
-
T
S
--
D
P
H
I
Y
A
I
G
D
A
I
E
V
-
K
DFVTE
T
E
T
--
M
---------
I
--------
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
-----------------------------------------------------------------------------------------------------------------------------
51
HHSearch
72.05
17%
-84
- C2 -
3LXD
1
?
A:
[7-321]
--------
A
E
R
A
D
V
V
I
V
G
A
G
H
G
G
A
Q
A
A
I
A
L
R
--
Q
N
G
-
F
-
E
G
R
V
L
V
I
-
G
R
E
P
E
I
-
P
Y
-
E
R
P
-
P
L
S
K
-
E
Y
L
-
A
-
R
E
K
T
------------
F
--
E
-
R
I
-
C
---------
I
R
P
A
Q
F
W
E
D
K
---
A
V
E
M
-
K
L
G
A
-
E
V
V
S
L
D
P
A
A
H
T
V
K
L
--------------------
G
-----
D
-----
G
--
S
A
I
E
Y
G
K
L
I
W
A
T
G
G
D
P
R
R
L
-
S
-
C
V
G
A
D
L
------
A
G
V
H
A
V
R
T
K
E
D
A
D
R
L
M
A
E
L
D
----------
A
G
------------------
A
K
-------------
N
A
-----
V
V
I
G
G
G
--------
Y
I
G
L
E
A
--
A
--
A
V
L
T
K
------
F
G
-----
V
N
V
T
L
L
E
A
L
P
R
V
L
A
RVA--
G
---
E
-
A
L
S
E
F
Y
Q
A
E
--
H
R
A
H
G
V
D
L
R
T
----
G
A
A
M
D
C
I
E
G
D
G
---
T
KVT------------------
G
---
V
R
M
Q
D
------
G
S
--
V
I
P
A
D
I
V
I
V
G
I
G
I
-----
V
P
-
C
V
G
-
A
L
I
S
-----
A
--
G
--
A
S
---
G
G
N
G
V
D
V
D
E
-
F
C
R
-
T
S
--
L
T
D
V
Y
A
I
G
D
C
A
A
H
-
A
----------
N
DFADG
A
V
I
R
L
--------
E
S
V
Q
N
A
N
D
M
A
T
A
A
A
K
D
I
C
G
A
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.06
20%
-62
- C2 -
1FCD
2
DHSU_ALLVD
A:
[29-312]
-----------------------------------------
E
V
T
L
I
-
E
P
N
T
D
Y
-
Y
T
-
C
-
Y
-
L
-
S
N
-
E
V
I
-
G
-
G
D
R
K
------------
L
--
E
-
S
I
-
K
---------
H
G
Y
D
G
L
R
A
-
H
---
G
I
Q
V
-
V
H
-
D
-
S
A
T
G
I
D
P
D
K
K
L
V
K
T
--------------------
A
-----
G
-----
G
--
A
E
F
G
Y
D
R
C
V
V
A
P
G
I
E
L
I
Y
D
-
K
-
I
E
G
Y
S
E
E
A
A
--
A
K
L
P
H
A
W
K
A
G
E
Q
T
A
I
L
R
K
Q
L
E
D
M
A
D
G
G
T
V
V
I
A
P
------------------
P
A
-------------
A
P
-----
F
R
C
P
P
G
--------
P
Y
E
R
A
S
Q
V
A
--
Y
Y
L
K
A
------
H
K
P
M
S
---
K
V
I
I
L
D
S
S
Q
T
F
S
K
-----
Q
---
S
-
Q
F
S
K
G
W
E
R
L
YG
F
G
T
E
N
A
M
I
E
W
H
P
G
P
D
S
A
V
V
K
V
D
G
G
E
M
M
V
E
---------------------
T
---
A
F
G
D
E
F
K
-
A
----------
D
V
I
N
L
I
P
P
Q
-----
R
A
-
G
-
K
-
I
A
Q
I
-----
A
--
G
--
L
T
-
N
-
D
A
G
W
C
P
V
D
I
K
T
F
E
S
S
I
--
H
K
G
I
H
V
I
G
D
A
S
I
A
N
P
----------
M
---------
P
--------
K
S
G
Y
S
A
N
S
Q
G
---------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
70.93
19%
-88
- C2 -
3KLJ
1
NROR_CLOAB
A:
[8-293]
---------
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
--
G
K
----
C
D
D
I
T
M
I
-
N
S
E
K
Y
L
P
Y
Y
-
R
-
P
-
R
-
L
N
-
E
I
I
-
A
-
K
N
K
S
------------
I
--
D
-
D
I
-
L
---------
I
K
K
N
D
W
Y
E
K
N
---
N
I
K
V
-
I
T
-
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
--------------------
K
-----
S
-----
G
--
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
-
K
-
V
P
H
A
D
--------
E
I
F
S
L
Y
S
Y
D
D
A
L
K
I
K
D
E
C
-----------
K
N
------------------
K
G
-------------
K
A
-----
F
I
I
G
G
G
--------
I
L
G
I
E
L
--
A
--
Q
A
I
I
D
------
S
G
-----
T
P
A
S
I
G
I
I
L
E
Y
P
L
E
-----
R
QLD
R
-
D
G
G
L
F
L
K
D
K
--
L
D
R
L
G
I
K
I
Y
T
----
N
S
N
F
E
E
M
--------------------------------------------
G
D
--
L
I
R
S
S
C
V
I
T
A
V
G
V
-----
K
P
-
N
L
D
-
F
I
K
D
-----
T
--
E
--
I
A
---
S
K
R
G
I
L
V
N
D
-
H
M
E
-
T
S
--
I
K
D
I
Y
A
C
G
D
V
A
E
F
-
Y
GK--------
N
---------
P
--------
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
70.13
16%
-86
- C2 -
3NTD
2
?
A:
[1-338]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
--
R
L
S
-
E
-
T
A
E
I
I
M
F
-
E
R
G
E
Y
V
-
S
F
-
A
-
N
C
G
-
L
P
-
Y
H
I
-
S
-
G
E
I
A
------------
Q
R
-
S
A
L
V
-
L
---------
Q
T
P
E
S
F
K
A
R
F
---
N
V
E
V
R
V
K
-
H
-
E
V
V
A
I
D
R
A
A
K
L
V
T
V
--------------------
R
RLLDG
S
-----
E
--
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
-
P
-
I
P
G
V
D
N
------
P
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
Q
M
---------
N
N
------------------
V
E
-------------
H
A
-----
T
V
V
G
G
G
--------
F
I
G
L
E
M
--
M
--
E
S
L
H
H
------
L
G
-----
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-----
P
VD-
R
-
E
M
A
G
F
A
H
Q
A
--
I
R
D
Q
G
V
D
L
R
L
----
G
T
A
L
S
E
V
S
Y
Q
V
---
Q
T
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
---
L
T
L
S
N
------
G
E
--
L
L
E
T
D
L
L
I
M
A
I
G
V
-----
R
P
-
E
T
Q
-
L
A
R
D
-----
A
--
G
--
L
A
I
G
-
E
L
G
G
I
K
V
N
A
-
M
M
Q
-
T
S
--
D
P
A
I
Y
A
V
G
D
A
V
E
E
-
Q
----------
D
FVTG
Q
A
C
L
-
V
--------
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
-----------------------------------------------------------------------------------------------------------------------------
38
HHSearch
68.84
17%
-88
- C2 -
2GQW
5
?
A:
[6-308]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
--
Q
A
G
-
Y
-
Q
G
L
I
T
V
V
-
G
D
E
A
E
R
-
P
Y
D
R
-
P
-
P
-
L
S
-
K
D
F
-
M
-
A
H
G
D
------------
A
--
E
-
K
I
-
R
---------
L
D
C
K
--
R
A
-
P
---
E
V
E
W
-
L
L
-
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
--------------------
S
-----
D
-----
G
--
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
-
L
Q
G
A
T
M
-------
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-----------
R
P
------------------
Q
S
-------------
R
L
-----
L
I
V
G
G
G
--------
V
I
G
L
E
L
--
A
--
A
T
A
R
T
------
A
G
-----
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
-----
R
AAP
A
-
T
L
A
D
F
V
A
R
Y
--
H
A
A
Q
G
V
D
L
R
F
----
E
R
S
V
T
G
S
V
D
G
--------------------------
V
---
V
L
L
D
D
------
G
T
--
R
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
-
N
D
A
-
L
A
R
A
-----
A
--
G
--
L
A
-
C
--
D
D
G
I
F
V
D
A
-
Y
G
R
-
T
T
--
C
P
D
V
Y
A
L
G
D
V
T
R
Q
-
R
----------
N
---------
P
LSGRFERI
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
-----------------------------------------------------------------------------------------------------------------------------
48
HHSearch
68.64
16%
-80
- C2 -
1M6I
1
AIFM1_HUMAN
A:
[9-372]
--------
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
--
A
R
D
-
P
-
G
A
R
V
L
I
V
-
S
E
D
P
E
L
-
P
Y
M
R
-
P
-
P
-
L
S
-
K
E
L
W
F
-
S
-
P
N
VTKTLRFKQWNG
K
E
-
R
-
S
I
Y
F
QPPSFYVSA
Q
D
L
P
H
I
E
N
-
G
---
G
V
A
V
-
L
T
G
K
-
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
--------------------
N
-----
D
-----
G
--
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
-
S
A
I
D
R
A
G
A
E
V
K
---
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
----
I
-------
S
R
E
------------------
V
K
-------------
S
I
-----
T
I
I
G
G
G
--------
F
L
G
S
E
L
--
A
--
C
A
L
G
R
------
K
A
R
A
L
G
-
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
KIL--
P
---
E
-
Y
L
S
N
W
T
M
E
K
--
V
R
R
E
G
V
K
V
M
P
----
N
A
I
V
Q
S
V
G
V
S
S
---
G
---------------------
K
L
L
-
I
K
L
K
D
------
G
R
--
K
V
E
T
D
H
I
V
A
A
V
G
L
-----
E
P
-
N
-
V
E
L
A
K
T
-----
G
--
G
--
L
E
I
D
S
D
F
G
G
F
R
V
N
A
-
E
L
Q
A
----
R
S
N
I
W
V
A
G
D
A
A
C
F
-
Y
----------
D
IKL
G
R
R
R
--
V
--------
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
-----------------------------------------------------------------------------------------------------------------------------