@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0089: (2016-03-12 )
MSQLLNDTLSAWLLIESLSPGEVNFTAEDILSAEHFKNGAKQAQLQSFDEYFEIWNSERFIISEEKSETGELIFKFYRHCFRYNEINLKIQDIFDDYSDIHNPNGTHCYGYTFNTDKHGKVIVDSIHIPMIMSALKEIEKNKNANIEEKFNDSVEKFFQKVKEILADEPINEFKLKKMDKAYDEYFSVLNSKKDGLFGHYVAIEYVKDSDLPQPEFNSFFISDIEKARKSPNQTLIDYIEGVEESQRIEVDENKEMFDKFLHPSRLPDGRWPSQTEFRLSLMQQLAVNQITSGNERISSVNGPPGTGKTTLLKDIFAHLVVERGKELAKLNNPKDAFVKTKIHETDDKYVYLLKESIAKYKMVVASSNNGAVENISKDLPKIEEIIRNPEKCKFPKYEQNYANLAHELKDFAEIAEDLIGESAWGLFSGVFGKSTNINQVLSHMLKQDANDIGFAKLLQNENNRMSYNELMSEWQSHQRAFLEELRHVEMLKEESIRAYDVYKNCESFSKIEQVINSEKTSIEEQVYHLDNETLRDNKEIEDLDNRINYIVKQIETLNELIKSIKESNKGFINKLKAMFNSEEDESYKDHNKEKQQLLTQQLELEKCKKNKHEDLVSKLKEKEKLIKQLTKVQLQLDELNSQLQELEAYRIESKITIPEKDFWSDNNYDERQVTNLWTSDELQYRRAMLFLRAMILHKLLLIANNTTIYYAINDFKDRRKLIDANPDKVHNAWNVMHLIFPVVSTTFASFKSMYGGIPKDFIDYLFIDEAGQAIPQAAVGALYRSKKVVAVGDPIQIEPVVTLESHLIDNIRKNYHVPEYLVSKEASVQSVADNANQYGFWKSDATDSNQKTWIGIPLWVHRRCLKPMFTIANQIAYNNKMVLPSNITKVGKTGWYDVKGNAVQKQFVKEHGEKVVGLLADDWIEAIKEGKNEPSSFVISPFSAVQQQIKRMLKQQLPTRIDIERTKINQWVDKSIGTVHTFQGKEAQKVYFVIGTDNTQDGAVNWSCEKPNLLNVAVTRAKKEFYVIGDMQRIQMKPFYETIFKERNVK
Atome Classification :
(20 SA)
.........10...--.....20........30........-40...-.....50..--..-.------------------...60-------........70........80...---.....90........100--------........110-.-.--.....120.......130.......140........150.--......160.......170...-....180.......-190.......200.......210.......220.......230...-....240.....----..250-.......260.......270.......280.......290.---......300.......310.......320.......330......---.--340.......350...-....360.......370......----.380.......390.......400....--...410.......420...-----.....430.-......440.......450..-----.....460.......----470.......480....--------------...490.......500.-......510.......520.......530....-...540---........550----....--....560.....-..570------.......---------580.....--....590..-...----....600.....----------..610----.........620....-------...630.......640...--....-650.......660....-...670.......-680---------........690......------.700.......710...-.---...720-------.......730.......-740.....--..750...--....760----.......-------..770---.-.-...--..780..---------------------...-..790.......800-------...--...--..810.......820..-.....830....--....840..-----------.....850.......860------....----....870...-....880-......-------------.890-..------------------...-------.--.----900-----.....-..910....--...920..-.....----930.....-----------------------------..940.......950.......960.......970.......980.......990.......1000......1010......1020......1030-.....----....1040--------------------------......1050------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
Q
L
L
N
D
T
L
S
A
W
L
L
--IESLSPGE
V
N
F
T
A
E
D
I
L
S
A
E
H
F
KNG-
A
K
Q
A
Q
-
L
Q
S
F
D
E
Y
F
E
--
I
W-N------------------SE
R
F
I
-------
I
SEEKS
E
T
G
E
L
I
F
K
F
Y
R
H
C
F
R
YN---EI
N
L
K
I
Q
D
I
F
D
D
Y
S
DIH---------NPNG
T
H
C
Y
G
Y
T
-F-N--TDKH
G
K
V
I
V
DSI
H
I
P
M
I
M
S
A
L
K
E
I
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KN-KNA
N
I
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K
F
N
D
S
--
V
E
K
F
F
Q
K
V
K
E
I
LADEP
I
N
E
F
K
L
-
K
K
M
D
K
A
Y
D
E
Y
F
S
V
L
-NSKKDG
L
F
G
H
Y
V
A
I
E
Y
VKDSDLPQP
E
F
N
S
F
F
I
S
D
I
E
K
A
RKSP
N
Q
T
L
-
I
D
Y
I
EGVEES
Q
R
----
I
EVDE-
N
K
E
M
F
D
K
FLHPSRLPDGRWPS
Q
T
E
F
R
L
S
L
M
Q
Q
L
A
V
N
QITSG---NERISSVNGPPGT
G
K
T
T
L
L
K
D
I
F
A
H
L
V
V
E
R
G
K
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L
A
KLNNPKD
A
F
V
---
K
--
T
KIHETDD
K
Y
V
Y
L
L
K
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-
S
I
A
K
Y
K
M
V
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ASSNNG
A
V
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N
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----
L
P
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IRN
P
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KCKFP
K
Y
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L
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-----
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L
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VFGK-ST
N
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KQDAN
D
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A
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QNENNRM
S
Y
N
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----
L
M
S
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W
Q
S
H
Q
R
A
F
L
E
E
L
R
--------------
H
V
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R
A
Y
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K
-
N
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SEKT
S
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Q
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HLDNETLRD-NK
E
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----
D
L
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N
R
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----
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T
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K
G
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------
N
K
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F---------N--SEEDE--SYKDH--
N
K
-
E
K
Q
----
Q
L
L
T
Q
Q
L
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L
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K
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K
H
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D
L
V
S
K
L
K
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K
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K
L
I
-------
K
Q
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K
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Q
L
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L
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L
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S
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L
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L
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A
Y
-RIESKITIPEKDFWSDN-NYD
E
R
Q
V
TNLWT
S
-
D
E
----------
L
Q
Y
R
R
A
M
L
F
L
R
A
M
I
L
H
K
------
L
L
L
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ANN
T
T
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IND
F
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R
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V
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------
F
I
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Y
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FI-------DEAGQ---A-
I
-
P
Q
A
--
A
V
G
A
L
Y
R---------------------S
K
K
-
V
V
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P
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Q
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--------
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L
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KNYHV
P
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SK-EA
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----
K
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M
F
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I
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N
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I-AYNN
K
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V-LPSN
I
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-------------KVGK-TG------------------
W
Y
D-------V--K----G
N
A
-----
V
Q
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Q
F
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V
K
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H
G
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K
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--
G
L
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S
F
-----------------------------
V
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T
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TFQGKE
A
Q
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F
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A
V
N
WSCEKP
N
L
L
N
V
A
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TRAK
K
E
F
Y
V
I
G
D
----
M
Q
R
IQ----M
K
P
F
Y
E
T
I
--------------------------
F
K
ERNVK---------------------
51
Fugue
72.57
13%
-3
- C2 -
2WJY
11
RENT1_HUMAN
A:
[2-799]
--
K
D
L
P
I
H
A
C
S
Y
C
-------
G
I
H
D
P
A
C
V
V
Y
C
N
T
S
K
K
W
F
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N
G
-
R
G
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-
G
S
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I
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N
H
L
V
--
R
A
-
K
------------------
C
K
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V
T
-------
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H
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D
G
P
L
G
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-----
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---
C
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N
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L
L
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----------------
P
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A
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S
--
Q
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------------------------------
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L
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K
L
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A
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Y
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K
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Q
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D
N
I
-------
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----
V
R
W
D
L
-
G
L
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K
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Y
F
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P
K
T
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S
R
L
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Q
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D
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L
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Y
--------------------------------------------------
K
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D
L
A
P
L
W
K
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---
I
--
G
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V
I
K
V
P
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N
----------
Y
G
D
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A
I
E
L
R
S
S
V
G
A
P
V
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T
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----
N
F
Q
V
D
F
V
W
K
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----------
T
S
F
D
R
M
Q
S
--
A
L
K
T
F
A
V
------------------------
D
E
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T
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Y
I
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L
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C
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G
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----
L
---
N
H
S
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V
Y
A
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K
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V
L
Q
----------------------------------
R
P
L
S
L
I
Q
G
P
P
G
T
G
K
T
V
T
S
A
T
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V
Y
H
L
A
R
Q
G
N
--------------
G
P
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L
V
C
-
A
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P
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N
I
--
A
V
D
Q
L
T
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Q
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G
L
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V
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------
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L
C
A
------------------------
K
S
R
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A
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I
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----
P
V
S
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L
A
L
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N
Q
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----------
N
M
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------
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M
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L
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K
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Q
Q
L
K
D
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M
-
N
A
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-----------------------------------------------------------------------------------------------------------------------
V
I
C
C
T
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--
V
G
A
G
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--
P
--
R
L
A
K
M
------
Q
F
R
S
I
L
I
-------
D
E
S
T
Q
---
A
T
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-
P
E
C
--
M
V
P
V
V
L
G
---------------------
A
K
Q
-
L
I
L
V
G
D
H
C
Q
L
G
P
V
V
--------
M
-----------------------------------
C
K
K
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A
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L
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Q
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L
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F
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R
L
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V
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I
R
L
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M
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P
A
L
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F
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I
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F
Y
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S
L
Q
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N
G
V
T
A
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D
R
V
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FDFQWPQPDKP
M
F
F
----
Y
V
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Q
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G
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A
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A
K
P
D
Q
I
G
-----------------------------
I
I
T
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Y
E
G
Q
R
S
Y
L
V
Q
Y
M
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F
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A
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V
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G
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----
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K
A
L
S
----
K
Q
P
L
W
N
H
L
--------------------------
L
N
Y
Y
K
E
Q
KVLVEGPLN
N
L
R
E
S
LMQF---
50
Fugue
71.20
14%
-12
- C2 -
4B3F
1
SMBP2_HUMAN
X:
[1-646]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
A
V
-
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S
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V
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K
Q
L
D
L
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K
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L
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RGVC
L
L
K
L
Q
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S
Q
R
T
G
L
Y
G
R
L
--------------
L
V
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V
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F
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K
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K
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N
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---
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I
K
L
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K
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W
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P
L
L
K
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K
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Q
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A
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L
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V
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----
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Q
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M
H
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A
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G
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Q
L
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A
H
-------
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A
----
R
H
L
L
R
D
L
P
G
V
-
A
A
T
E
E
T
G
-
V
P
L
L
L
V
-------------
D
T
A
G
-
C
G
------------------
L
F
E
-------
L
--
E
----
S
K
G
---------------
N
P
G
E
V
--
R
L
V
S
L
H
I
Q
-
A
L
V
D
A
----
G
V
P
A
R
D
I
A
-----------------------------
V
V
S
P
Y
N
L
Q
V
D
L
L
R
Q
S
L
V
H
R
H
P
--------------
E
L
E
I
K
S
V
D
G
F
Q
G
R
E
K
E
A
V
I
L
S
F
V
R
S
N
R
K
G
E
V
G
F
L
A
--
E
D
R
R
I
N
V
A
V
T
R
A
R
R
H
V
A
V
I
C
D
----
S
R
T
V
N
----
N
H
A
F
L
K
T
L
--------------------------
V
E
Y
F
T
Q
H
GEVRTAFEYLDDIVP------
49
Fugue
67.86
14%
-15
* C2 *
2GK6
3
RENT1_HUMAN
A:
[3-621]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
R
Y
E
D
-
A
Y
Q
Y
Q
N
I
F
G
P
L
V
K
L
E
A
D
Y
D
K
K
-----
L
K
E
S
Q
T
Q
D
N
----------
I
T
V
R
W
D
L
G
L
N
K
K
R
I
A
Y
F
--------------
T
L
P
L
M
Q
G
D
E
I
C
L
R
Y
K
G
D
-
L
A
P
L
W
K
G
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G
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Y
G
D
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I
A
I
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L
R
S
S
V
G
A
P
-
V
E
V
T
H
----
N
F
Q
V
D
F
V
W
K
-
S
----
T
S
F
D
--
R
M
Q
S
A
L
K
T
F
A
V
D
-
E
T
S
V
S
------
G
Y
I
Y
H
K
L
---------
L
--
G
H
E
V
E
--
D
V
I
I
K
--
C
Q
-
L
P
K
----
R
F
T
A
Q
G
L
P
--
D
L
----------
N
H
S
------
Q
V
Y
A
V
K
T
V
L
Q
R
P
L
S
L
I
Q
G
P
PGTG
K
T
V
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A
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Y
H
L
A
R
Q
G
N
G
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--
V
L
V
C
A
P
S
N
I
A
V
D
Q
L
T
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K
I
H
Q
T
G
--------
L
K
V
V
R
L
-
C
A
----------
K
S
R
E
A
I
D
S
P
V
S
F
L
A
L
H
N
------
Q
I
R
N
M
D
S
M
P
E
L
Q
K
L
Q
Q
L
-
K
---
D
L
S
S
A
D
-------
E
K
R
Y
R
A
L
K
R
T
A
E
R
E
L
L
M
N
A
D
V
I
C
C
T
C
--
V
G
A
G
D
--
P
--
R
L
A
K
M
------
Q
F
R
S
I
L
I
-------
D
E
S
T
Q
---
A
T
E
-
P
E
C
--
M
V
P
V
V
L
G
---------------------
A
K
Q
-
L
I
L
V
G
D
H
C
Q
L
G
P
V
V
--------
M
-----------------------------------
C
K
K
A
--
A
K
A
G
L
S
Q
S
L
-----------
F
E
R
L
V
V
L
G
I
R
P
I
R
L
Q
V
Q
-------
Y
R
M
H
----
P
A
L
S
A
F
P
S
N
I
-
F
Y
E
G
S
L
Q
-
N
G
V
T
A
A
-------------
D
R
V
K
-
K
G
FDFQWPQPDKPMF-----
F
Y
V
-------
T
--
Q
----
G
Q
E
-----
E
I
A
S
S
G
T
S
Y
L
N
R
T
E
A
--
A
N
V
E
K
I
T
T
-
K
L
L
K
A
----
G
A
K
P
D
Q
I
G
-----------------------------
I
I
T
P
Y
E
G
Q
R
S
Y
L
V
Q
Y
M
Q
F
S
G
S
L
-------
H
T
K
L
Y
Q
E
V
E
I
A
S
V
D
A
F
Q
G
R
E
K
D
F
I
I
L
S
C
----
V
R
I
G
F
L
N
----
D
P
R
R
L
N
V
A
L
T
R
A
R
Y
G
V
I
I
V
G
N
----
P
K
A
L
S
----
K
Q
P
L
W
N
H
L
--------------------------
L
N
Y
Y
K
E
Q
KVLVEGPLNN
L
R
E
S
LM-----
54
Fugue
66.62
18%
38
- C2 -
4PJ3
3
AQR_HUMAN
A:
[1-1363]
N
A
E
F
V
T
Q
L
A
C
K
Y
W
A
PH
I
K
K
K
S
P
F
D
I
K
-
V
I
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D
I
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E
K
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K
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R
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A
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R
K
I
M
L
L
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F
S
Q
Y
L
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NY
L
W
M
N
YSPEVSS
K
A
Y
L
M
S
I
C
C
M
V
N
E
K
F
R
E
NVPAW
E
I
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K
K
K
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L
K
A
A
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TDG
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L
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L
L
L
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LEV
D
L
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Q
L
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L
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M
W
M
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LQ
L
A
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L
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L
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L
K
K
T
P
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L
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A
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R
W
F
N
T
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L
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L
L
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C
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L
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L
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R
R
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D
G
H
L
F
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L
L
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L
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T
G
F
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R
A
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A
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F
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L
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D
F
A
L
S
N
V
A
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------
D
T
---
R
E
S
L
V
K
F
F
G
P
L
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--
S
N
T
L
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A
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L
C
L
L
P
T
L
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K
N
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F
D
K
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F
L
L
---
E
L
L
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R
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R
R
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S
Q
I
Q
Q
L
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Q
M
P
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P
T
E
K
I
I
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D
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N
I
V
P
T
E
Y
Y
S
G
E
GCLA
L
P
K
L
-----
N
L
Q
F
L
T
L
H
D
Y
L
L
R
N
F
N
L
F
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L
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R
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R
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V
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N
L
N
V
R
D
H
I
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D
----
E
W
E
G
L
R
K
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D
V
C
F
L
I
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V
R
PTKPYG
T
K
F
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RRRP
F
I
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V
G
L
V
Y
V
R
G
C
E
I
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G
M
L
D
D
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G
R
V
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P
R
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N
L
R
G
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R
T
F
R
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F
L
D
P
N
Q
Y
Q
Q
D
M
T
N
T
I
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NGAE
D
V
Y
E
T
F
N
I
I
M
R
----
R
K
P
K
EN
N
F
K
A
V
L
E
T
I
R
N
L
M
N
T
D
C
V
VP----
D
W
L
H
D
I
I
---------
L
--
G
Y
G
D
P
--
S
S
A
H
Y
--
S
K
M
P
N
Q
IATL
D
F
N
D
T
F
L
S
I
E
H
L
----------
K
A
S
------
F
P
G
H
N
V
K
V
T
V
E
D
P
A
L
---------
Q
I
P
P
F
R
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T
F
P
V
E
A
K
T
L
I
---
V
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H
-
V
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G
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PG
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Y
H
N
F
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Q
R
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L
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F
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A
L
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D
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L
L
R
L
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HGEE
E
L
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T
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K
D
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G
R
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Y
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L
A
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--
E
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K
R
L
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T
C
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T
A
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Y
F
F
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QV
M
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R
W
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Y
I
S
---
K
-
V
-
K
N
P
--
D
V
T
E
V
S
T
F
FPFHEYFANAPQPIFKGRS
Y
E
E
D
M
E
I
A
E
G
C
F
R
H
I
K
K
I
F
--------
T
Q
L
--
E
E
F
R
A
S
E
L
L
R
S
G
L
D
R
S
K
Y
L
L
V
K
-
E
A
K
I
I
A
M
T
C
T
H
A
A
L
K
R
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D
L
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K
L
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FKYD
N
I
L
M
E
EA
A
Q
I
L
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I
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T
F
I
P
L
L
L
Q
N
P
Q
DGFSRL
K
R
W
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I
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D
H
H
Q
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P
P
V
I
K
N
M
A
F
Q
K
Y
S
N
M
E
Q
S
L
F
T
-------------
R
F
V
R
-
V
G
V
P
T
V
D
L
D
A
QGRAR
A
S
L
C
N
L
Y
N
-------
W
--
R
YKN
L
G
N
L
-----
P
H
V
Q
L
-
L
P
E
F
S
T
A
N
A
--
G
L
L
Y
D
F
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L
-
I
N
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D
FQGV
G
E
S
E
P
N
P
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FYQN
L
G
E
A
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Y
V
V
A
L
F
M
Y
M
C
L
L
GYPADK
I
S
I
L
T
T
Y
N
G
Q
K
H
L
I
R
D
I
I
N
R
R
C
G
N
N
P
L
I
G
R
P
N
-------
K
V
T
T
V
D
R
F
Q
G
Q
--
Q
N
D
Y
I
L
L
S
L
V
R
T
R
--
A
V
G
H
L
R
D
V
R
R
L
--
V
V
A
S
R
A
R
L
G
L
Y
I
F
A
R
----
V
S
L
F
Q
N
C
FE
L
T
P
A
F
S
Q
L
T
A
RPLHLHIIPTEPFPTTRKNGERPS
H
E
V
Q
I
I
K
NP
Q
A
N
F
V
Y
N
Y
H
L
I
Q
T
T
H
H
Y
H
Q
1
PsiBlast_PDB
55.40
22%
-26
- C3 -
4B3F
1
SMBP2_HUMAN
X:
[347-626]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
N
T
G
--
A
S
A
D
G
P
L
K
--
L
L
P
E
S
------
Y
F
D
V
V
V
I
-------
D
E
C
A
Q
---
A
-
L
-
E
A
S
--
C
W
I
P
L
L
K
---------------------
A
R
K
-
C
I
L
A
G
D
H
K
Q
L
P
P
----------
T
T
V
--
S
H
K
--
A
A
L
A
G
L
S
L
S
L
M
E
R
L
-
A
E
-
E
Y
G
A
R
V
-
V
R
T
L
T
--
V
Q
Y
R
M
H
Q
A
I
-----------
M
R
W
A
S
D
T
M
Y
L
G
-
Q
L
T
A
H
-------
S
S
V
A
----
R
H
L
L
R
D
L
P
G
V
-
A
A
T
E
E
T
G
-
V
P
L
L
L
V
-------------
D
T
A
G
-
C
G
------------------
L
F
E
-------
L
ES
K
----
G
N
P
-----
G
E
V
R
L
-
V
S
L
H
I
Q
A
L
V
DA
G
V
P
A
R
D
I
A
-----------------------------------------------
V
V
S
P
Y
N
L
---
Q
V
D
-
L
L
R
Q
S
L
----------
V
H
R
H
P
E
L
E
I
K
S
V
D
G
F
Q
G
R
E
K
E
A
V
I
L
S
F
V
R
S
N
-
R
K
G
E
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G
F
L
A
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D
R
R
-
I
N
V
A
V
T
R
A
R
R
H
V
A
V
I
C
D
----
S
R
T
V
N
----
N
H
A
F
L
K
T
L
--------------------------
V
E
--------------------------
29
HHSearch
54.56
18%
-49
- C3 -
2WJY
6
RENT1_HUMAN
A:
[493-779]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
N
-
A
D
V
I
C
C
T
C
--
V
G
A
G
D
P
R
----
L
A
K
M
------
Q
F
R
S
I
L
I
-------
D
E
S
T
Q
---
A
-
T
-
E
P
E
--
C
M
V
P
V
V
L
G--------------------
A
K
Q
-
L
I
L
V
G
D
H
C
Q
L
G
P
V
V
--------
M
C
K
--
K
A
A
--
K
A
G
-----------------
L
S
Q
S
-
L
F
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R
L
--
V
V
L
G
I
------------------------
R
P
I
R
L
Q
V
Q
-------
Y
R
M
H
----
P
A
L
S
A
F
P
S
N
I
-
F
Y
E
G
S
L
Q
-
N
G
V
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A
A
DRVKKGFDFQWPQ
P
D
K
P
-
M
F
------------------
F
Y
V
-------
T
--
Q
----
G
Q
E
E
I
A
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G
T
S
Y
L
-
N
R
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A
A
N
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--
K
I
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T
K
L
L
K
-
A
G
A
--------
K
P
D
Q
I
G
-----------------------------
I
I
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Y
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G
Q
R
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Y
L
V
Q
Y
M
Q
F
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G
S
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-------
H
T
K
L
Y
Q
E
V
E
I
A
S
V
D
A
F
Q
G
R
E
K
D
F
I
I
L
S
C
V
R
A
N
E
-
H
Q
G
I
G
F
-
L
N
D
P
R
R
L
N
V
A
L
T
R
A
R
Y
G
V
I
I
V
G
N
----
P
K
A
L
S
----
K
Q
P
L
W
N
H
L
--------------------------
L
N
Y
Y
K
-----------------------
30
HHSearch
52.77
17%
-48
* C3 *
2XZL
14
NAM7_YEAST
A:
[496-781]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
K
-
A
D
V
V
C
C
T
C
--
V
G
A
G
D
K
R
----
L
-
D
T
------
K
F
R
T
V
L
I
-------
D
E
S
T
Q
---
A
-
S
-
E
P
E
--
C
L
I
P
I
V
K
G--------------------
A
K
Q
-
V
I
L
V
G
D
H
Q
Q
L
G
P
V
I
--------
L
E
R
--
K
A
A
--
D
A
G
-----------------
L
K
Q
S
-
L
F
E
R
L
--
I
S
L
G
H
V
------------------------
P
I
R
L
E
V
Q
-------
Y
R
M
N
----
P
Y
L
S
E
F
P
S
N
M
-
F
Y
E
G
S
L
Q
-
N
G
V
T
I
E
QRTVPNSKFPWPI
R
G
I
P
-
M
M
------------------
F
W
A
-------
N
--
Y
----
G
R
E
E
I
S
AN
G
T
S
F
L
-
N
R
I
E
A
M
N
C
E
--
R
I
I
T
K
L
F
R
-
D
G
V
--------
K
P
E
Q
I
G
-----------------------------
V
I
T
P
Y
E
G
Q
R
A
Y
I
L
Q
Y
M
Q
M
N
G
S
L
-------
D
K
D
L
Y
I
K
V
E
V
A
S
V
D
A
F
Q
G
R
E
K
D
Y
I
I
L
S
C
V
R
A
N
E
-
Q
Q
A
I
G
F
-
L
R
D
P
R
R
L
N
V
G
L
T
R
A
K
Y
G
L
V
I
L
G
N
----
P
R
S
L
A
----
R
N
T
L
W
N
H
L
--------------------------
L
I
H
F
R
-----------------------
28
HHSearch
52.20
17%
-61
- C3 -
2GK6
3
RENT1_HUMAN
A:
[313-603]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
L
L
M
N
-
A
D
V
I
C
C
T
C
--
V
G
A
G
D
P
R
----
L
A
K
M
------
Q
F
R
S
I
L
I
-------
D
E
S
T
Q
---
A
-
T
-
E
P
E
--
C
M
V
P
V
V
L
G--------------------
A
K
Q
-
L
I
L
V
G
D
H
C
Q
L
G
P
V
V
--------
M
C
K
--
K
A
A
--
K
A
G
-----------------
L
S
Q
S
-
L
F
E
R
L
--
V
V
L
G
I
------------------------
R
P
I
R
L
Q
V
Q
-------
Y
R
M
H
----
P
A
L
S
A
F
P
S
N
I
-
F
Y
E
G
S
L
Q
-
N
G
V
T
A
A
DRVKKGFDFQWPQ
P
D
K
P
-
M
F
------------------
F
Y
V
-------
T
--
Q
----
G
Q
E
E
I
A
SS
G
T
S
Y
L
-
N
R
T
E
A
A
N
V
E
--
K
I
T
T
K
L
L
K
-
A
G
A
--------
K
P
D
Q
I
G
-----------------------------
I
I
T
P
Y
E
G
Q
R
S
Y
L
V
Q
Y
M
Q
F
S
G
S
L
-------
H
T
K
L
Y
Q
E
V
E
I
A
S
V
D
A
F
Q
G
R
E
K
D
F
I
I
L
S
C
V
R
-------
I
G
F
-
L
N
D
P
R
R
L
N
V
A
L
T
R
A
R
Y
G
V
I
I
V
G
N
----
P
K
A
L
S
----
K
Q
P
L
W
N
H
L
--------------------------
L
N
Y
Y
K
-----------------------
32
HHSearch
49.09
16%
-43
- C3 -
3VKW
3
A:
[216-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
R
T
V
--
D
S
F
L
M
N
Y
G
--
K
G
A
R
C
------
Q
F
K
R
L
F
I
-------
D
E
G
L
M
---
L
-
H
-
T
G
C
V
N
F
L
V
E
M
S
L
---------------------
C
D
I
-
A
Y
V
Y
G
D
T
Q
Q
I
P
Y
I
N
--------
R
V
T
--
G
F
P
---------------
Y
P
-------
A
H
-
F
A
K
------
L
-----------------------
E
V
D
E
V
E
T
R
R
T
T
-------
L
R
C
P
----
A
D
V
T
H
F
L
N
Q
--
R
Y
E
G
H
V
M
-
C
T
S
S
E
---------------
K
K
S
-
V
S
------------------
Q
E
M
-------
V
--
S
---------------------
G
A
A
S
I
N
---------
P
-
V
S
---------
K
P
L
K
G
K
-----------------------------
I
L
T
F
T
Q
S
D
K
E
A
L
L
S
R
-------------------
G
Y
A
D
V
H
T
V
H
E
V
Q
G
E
T
Y
A
D
V
S
L
V
R
L
T
P
T
P
V
----
S
I
I
A
R
D
S
P
H
V
L
V
S
L
S
R
H
T
K
S
L
K
Y
Y
T
V
----
V
M
---------
D
P
L
V
S
I
--------------------------
I
R
D
L
------------------------
18
PsiBlast_PDB
49.08
20%
-9
- C3 -
2XZL
14
NAM7_YEAST
A:
[521-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
-------
D
E
S
T
Q
---
A
-
S
E
P
E
C
--
L
I
P
I
V
K
G
---------------------
A
K
Q
-
V
I
L
V
G
D
H
Q
Q
L
G
P
V
I
LE
R
K
A
A
D
A
G
L
K
--
Q
S
L
--
F
E
R
L
I
S
L
G
H
V
P
I
R
L
---------
E
-
V
Q
Y
R
M
--
N
P
Y
----
L
S
-----------
E
F
P
S
N
M
---------
F
Y
-------
E
G
S
L
----
Q
N
G
V
T
I
E
Q
R
T
-
V
P
N
S
K
F
P
-
W
P
--
I
R
-------------
G
I
P
M
-
M
F
------------------
W
A
N
Y
G
R
E
E
I
S
A
--
N
----
G
T
S
-----
F
L
N
R
I
-
E
A
M
N
C
E
R
I
I
--
T
K
L
F
R
D
G
V
-
K
P
E
Q
I
----
G
------------------------------------
V
I
T
P
Y
E
G
Q
R
A
Y
I
L
Q
Y
M
Q
M
N
G
S
L
D
K
D
L
-------
Y
I
K
V
E
V
A
S
V
D
A
F
Q
G
R
E
--
K
D
Y
I
I
L
S
C
V
R
A
N
E
Q
Q
A
I
G
F
L
R
D
P
R
R
L
N
V
G
L
T
R
A
K
Y
G
L
V
I
L
G
N
----
P
R
S
L
A
----
R
N
T
L
W
N
H
L
L
I
H
-----------------------
F
R
E
K
G
C
----------------------
52
Fugue
47.18
9%
5
- C2 -
1W36
-
RECD_ECOLI
D:
[2-606]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
Q
K
Q
L
L
E
A
V
E
H
K
Q
L
R
-
P
L
D
V
Q
----
F
A
L
T
V
A
G
D
E
-
H
----
P
A
V
T
--
L
A
A
A
L
L
S
H
D
A
G
E
-
G
H
V
C
L
PLSRLE
N
N
E
A
S
H
P
---------
L
--
L
A
T
C
V
--
S
E
I
G
E
--
L
Q
-
N
W
E
----
E
C
L
L
A
S
Q
A
V
S
R
G
----------
D
E
P
TPMILC
G
D
R
L
Y
L
N
R
M
W
C
N
E
R
T
V
-------
A
R
F
F
N
E
V
N
H
A
I
E
V
D
E
A
L
L
A
--
Q
T
L
D
-
K
L
F
P
V
S
D
E
I
N
W
Q
K
V
A
A
A
-
V
A
L
T
R
R
I
S
V
I
S
G
G
-
P
G
------------
T
G
K
T
T
T
V
A
K
L
L
A
A
L
I
------
Q
M
A
D
G
E
R
C
R
I
R
L
A
A
P
T
G
-
K
---
A
A
A
R
L
T
-------
E
S
L
G
K
A
L
R
Q
L
-
P
L
T
D
E
Q
-
K
K
R
I
P
E
D
A
--
S
T
L
H
R
L
L
H
--
A
G
N
P
L
------
H
L
D
V
L
V
V
-------
D
E
A
S
M
IDL
P
-
M
-
M
S
R
--
L
I
D
A
L
P
D
---------------------
H
A
R
-
V
I
F
L
G
D
R
D
Q
L
A
S
V
E
--------
A
G
A
VL
G
D
I
--
C
A
Y
A
N
A
G
F
T
A
E
R
A
R
Q
L
S
-
R
L
T
G
T
H
-
V
P
A
G
T
--
G
T
E
A
A
S
L
R
D
-----------
S
L
C
L
L
Q
K
S
Y
R
F
G
S
D
S
G
I
-------
G
Q
L
A
----
A
A
I
N
R
G
D
K
T
A
-
V
K
T
V
F
Q
Q
-
D
F
T
D
I
E
-------------
K
R
L
L
Q
S
G
------------------
E
D
Y
-------
I
--
A
----
M
L
E
-----
E
A
L
A
G
-
Y
G
R
Y
L
D
L
L
Q
--
A
R
A
E
P
D
L
I
-
I
Q
A
F
N
----
E
----
Y
Q
L
-----------------------------
L
C
A
L
R
E
G
P
F
G
V
A
G
L
N
E
R
I
E
Q
F
M
Q
Q
K
R
Q
P
S
R
L
P
E
H
E
T
T
W
A
M
T
V
H
K
S
Q
G
S
E
F
D
H
A
A
L
I
L
P
S
Q
R
T
P
V
V
T
-------
R
E
L
V
Y
T
A
V
T
R
A
R
R
R
L
S
L
Y
A
D
ERIL
S
A
A
I
A
----
T
R
T
E
R
R
S
G
--------------------------
L
A
A
L
F
S
S
---------------------
53
Fugue
38.69
15%
85
- C2 -
4WHE
1
?
A:
[3-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
R
F
A
D
I
V
N
A
N
I
N
A
L
L
E
D
P
Q
K
L
V
R
L
M
I
Q
E
M
E
D
T
L
V
----
E
V
R
S
T
S
A
R
A
-
L
----
A
E
K
K
--
Q
L
T
R
R
I
E
Q
A
S
A
R
-
E
V
E
W
Q
------
E
K
A
E
L
A
L
---------
L
--
K
E
R
E
D
--
L
A
R
A
A
--
L
I
-
E
K
Q
----
K
L
T
D
L
I
K
S
L
E
H
E
----------
V
T
L
------
V
D
D
T
L
A
R
M
K
K
E
I
G
E
L
E
-------
N
K
L
S
E
T
R
A
R
Q
Q
A
L
M
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
38.56
17%
136
- C2 -
2FXO
-
MYH7_HUMAN
A:
[-3-963]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
K
S
A
E
R
E
K
E
M
A
S
M
-
K
E
E
F
T
----
R
L
K
E
A
L
E
K
S
-
E
----
A
R
R
K
--
E
L
E
E
K
M
V
S
L
L
Q
E
-
K
N
D
L
Q
------
L
Q
V
Q
A
E
Q
---------
D
N
L
A
D
A
E
E
--
R
C
D
Q
L
--
I
K
-
N
K
I
----
Q
L
E
A
K
V
K
E
M
N
K
R
----------
L
E
D
------
E
E
E
M
N
A
E
L
T
A
K
K
R
K
L
E
-------
D
E
C
S
E
L
K
R
D
I
D
D
L
E
L
T
L
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
36.43
26%
113
- C3 -
1W36
-
RECD_ECOLI
D:
[149-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
N
W
Q
K
V
A
A
A
V
A
L
T
-----
R
R
I
S
V
I
S
G
G
P
G
T
G
K
T
T
T
V
A
K
L
L
A
A
L
I
Q
M
-
A
D
-------------------------------------
G
E
R
C
R
I
R
L
A
A
P
T
G
K
A
A
A
R
L
T
E
S
----
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
36.12
30%
106
- C3 -
3E1S
-
RECDL_DEIRA
A:
[640-695]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
A
L
T
V
H
R
A
Q
G
S
E
W
G
T
V
L
G
V
L
H
E
A
H
M
-------
P
M
L
S
R
N
L
V
Y
T
A
L
T
R
A
R
D
R
F
F
S
A
G
S
----
A
S
A
W
Q
----
I
-------------------------------------------------------------
48
HHSearch
36.07
24%
95
- C3 -
1PJR
-
PCRA_GEOSE
A:
[9-107]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
-------
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
H
--------------------------------------
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
----
V
Q
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
35.94
18%
13
- C3 -
1UAA
1
REP_ECOLI
A:
[206-369]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------
K
I
R
Y
L
L
V
-------
D
E
Y
Q
D
---
T
-
N
-
T
S
Q
Y
E
L
V
K
L
L
V
G
S--------------------
R
A
R
-
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
----------
R
---------------
G
----------
A
R
P
Q
N
-
L
V
L
L
S
--
Q
D
F
-----------------------
P
A
L
K
V
I
K
L
E
Q
N
-------
Y
R
S
S
----
G
R
I
L
K
A
A
N
I
L
-
I
A
N
N
P
H
V
-
F
E
K
R
L
F
S
ELG---------
Y
G
A
E
-
L
K
------------------
V
L
S
-------
A
--
N
----------------
N
-
E
E
H
E
A
E
R
V
T
--
G
E
L
I
A
H
H
F
V
N
K
T
--------
Q
Y
K
D
Y
A
-----------------------------
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
35.80
13%
182
- C2 -
4LL7
11
SHE3_YEAST
A:
[2-95]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
I
E
S
L
H
D
Q
-
I
D
M
L
T
------
K
T
N
L
Q
L
T
---------
T
--
Q
S
Q
N
L
L
S
K
L
E
L
A
--
Q
S
-
K
E
S
----
K
L
L
E
N
L
N
L
L
K
N
E
----------
N
E
N
------
L
N
S
I
F
E
R
K
N
K
K
L
K
E
L
E
-------
K
D
Y
S
E
L
S
N
R
Y
N
E
Q
K
E
K
M
D
Q
--
L
S
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
35.54
35%
226
- C3 -
3UPU
-
DDA_BPT4
A:
[23-71]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
L
T
E
G
Q
K
N
A
F
N
I
V
M
K
A
I
K
E
K
K
H
H
V
T
I
N
G
P
A
G
T
G
A
T
T
L
T
K
F
I
I
E
A
L
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
35.48
36%
172
- C3 -
2GK7
1
A:
[197-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
I
Q
G
P
P
G
T
G
K
T
V
T
S
A
T
I
V
Y
H
L
-
A
R
Q
G
N
G
P
V
L
V
C
A
P
S
N
I
A
V
D
Q
L
T
--
E
K
I
H
Q
T
G
L
K
V
V
R
L
C
A
K
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------