@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0098: (2016-03-12 )
MNQQLIEALKSKEDKMIEIRRYLHQHPELSFHEDETAKYIAEFYKGKDVEVETNVGPRGIKVTIDSGKPGKTLAIRADFDALPITEDTGLSFASQNKGVMHACGHDAHTAYMLVLAETLAEMKDSFTGKVVVIHQPAEEVPPGGAKAMIENGVLDGVDHVLGVHVMSTMKTGNVYYRPGYVQTGRAFFKLKVQGKGGHGSSPHMANDAIVAGSYFVTALQTVVSRRLSPFETGVVTIGSFDGKGQFNVIKDVVEIEGDVRGLTDATKATIEKEIKRLSKGLEDMYGVTCTLEYNDDYPALYNDPEFTEYVAKTLKEANLDFGVEMCEPQPPSEDFAYYAKERPSAFIYTGAAVEDGEIYPHHHPKFNISEKSLLISAEAVGTVVLDYLKGDN
Atome Classification :
(20 SA)
.........10-...--......20..----------......30.----------.---......40......---..50-..--.------------------------------------.--------------------.--...60......-.-.-70........80......-------------------------------.-.--90....----.-..-.100...-------....110.......120.......130.......-140---......--.-..150.--..---------------------....160-----------.......---..170---...--....180.-......190.--......-200-.-.-......210.......220.....-------------------------------..-------------------230--.........240.---.-.....250.......260.......270.......280...----..-..290..----.-..-.--.---300.---.--..-.....310.......320..--.----.--...330..-.....-340----.....----....350.......360.-.--....----.370--......---.380.......390-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
Q
Q
L
I
E
A
L
K
--SKE--
D
K
M
I
E
I
R
R
Y
L
----------
H
QHPELSFH----------
E
---
D
E
T
A
K
Y
I
A
E
F
YKGK---D
V
E
V
-
E
T--N------------------------------------V--------------------G--P
R
G
I
K
V
T
IDSG-K-P-G
K
T
L
A
I
R
ADFDALPITED-------------------------------T-G--LSFASQ----N-K
G
-
V
M
H
ACGH-------D
A
H
T
A
Y
M
L
V
L
A
E
T
L
A
E
M
K
D
SFT
G
K
V
V
V
I
HQ
P
A
E
E-V-----PPG
G
A
K
--
A
-
M
I
ENG
V
--
L
D
---------------------
G
V
D
H
V
-------------
L
G
V
H
V
M
S---TMKTG---
N
V
Y
--YRPGYVQT-G
R
A
F
F
K
L
K
V
Q
--GKGGHG-S-S-P-H-MAND
A
I
V
A
G
S
Y
F
V
T
A
L
Q
T
V
V
S
RRL-------------------------------SP-------------------F----ET
G
V
V
T
I
GSFDGK---G-
Q
F
N
V
I
K
D
V
V
E
IEGDVRGL
T
D
A
T
K
A
T
I
E
K
E
I
K
R
L
S
K
G
L
E
D
MY----
G
V
-
T
C
T
L
E
YN----D-DY-P--A---L--Y---N--D
P
-
E
F
T
E
Y
V
A
K
T
L
K
E
ANLDFG
V
E
--M----C--EPQPPS
E
D
-
F
A
Y
Y
A
-K------ERP
S
A
----
F
I
Y
TGAAVEDGEIYPHHH-P--KFNI----SE
K
S
--
L
L
I
S
A
E
---
A
V
G
T
V
V
L
D
Y
LKGDN-
19
PsiBlast_CBE
99.69
98%
-95
- C3 -
4EWT
4
?
C:
[1-389]
M
N
Q
Q
L
I
E
T
L
K
--
S
K
E
--
G
K
M
I
E
I
R
R
Y
L
----------
H
Q
H
P
E
L
S
F
H
----------
E
---
D
E
T
A
K
Y
I
A
E
F
Y
K
G
K
---
D
V
E
V
-
E
T
--
N
------------------------------------
V
--------------------
G
--
P
R
G
I
K
V
T
I
D
S
G
-
K
-
P
-
G
K
T
L
A
I
R
A
D
F
D
A
L
P
I
T
E
D
-------------------------------
T
-
G
--
L
S
F
A
S
Q
----
N
-
K
G
-
V
M
H
A
C
G
H
-------
D
A
H
T
A
Y
M
L
V
L
A
E
T
L
A
E
M
K
D
S
F
T
G
K
V
V
V
I
H
Q
P
A
E
E
-
V
-----
P
P
G
G
A
K
--
T
-
M
I
E
N
G
V
--
L
D
---------------------
G
V
D
H
V
-------------
L
G
V
H
V
M
S
---
T
M
K
T
G
---
K
V
Y
--
Y
R
P
G
Y
V
Q
T
-
G
R
A
F
F
K
L
K
V
Q
--
G
K
G
G
H
G
-
S
-
S
-
P
-
H
-
M
A
N
D
A
I
V
A
G
S
Y
F
V
T
A
L
Q
T
V
V
S
R
R
L
-------------------------------
S
P
-------------------
F
----
E
T
G
V
V
T
I
G
S
F
D
G
K
---
G
-
Q
F
N
V
I
K
D
V
V
E
I
E
G
D
V
R
G
L
T
D
A
T
K
A
T
I
E
K
E
I
K
R
L
S
K
G
L
E
D
M
Y
----
G
V
-
T
C
T
L
E
Y
N
----
D
-
D
Y
-
P
--
A
---
L
--
Y
---
N
--
D
P
-
E
F
T
E
Y
V
A
K
T
L
K
E
A
N
L
D
F
G
V
E
--
M
----
C
--
E
P
Q
P
P
S
E
D
-
F
A
Y
Y
A
-
K
------
E
R
P
S
A
----
F
I
Y
T
G
A
A
V
E
N
G
E
I
Y
P
H
H
H
-
P
--
K
F
N
I
----
S
E
K
S
--
L
L
I
S
A
E
---
A
V
G
T
V
V
L
D
Y
L
K
----
1
PsiBlast_PDB
99.53
98%
-95
- C3 -
4EWT
4
?
A:
[1-389]
M
N
Q
Q
L
I
E
T
L
K
--
S
K
E
--
G
K
M
I
E
I
R
R
Y
L
----------
H
Q
H
P
E
L
S
F
H
----------
E
---
D
E
T
A
K
Y
I
A
E
F
Y
K
G
K
---
D
V
E
V
-
E
T
--
N
------------------------------------
V
--------------------
G
--
P
R
G
I
K
V
T
I
D
S
G
-
K
-
P
-
G
K
T
L
A
I
R
A
D
F
D
A
L
P
I
T
E
D
-------------------------------
T
-
G
--
L
S
F
A
S
Q
----
N
-
K
G
-
V
M
H
A
C
G
H
-------
D
A
H
T
A
Y
M
L
V
L
A
E
T
L
A
E
M
K
D
S
F
T
G
K
V
V
V
I
H
Q
P
A
E
E
-
V
-----
P
P
G
G
A
K
--
T
-
M
I
E
N
G
V
--
L
D
---------------------
G
V
D
H
V
-------------
L
G
V
H
V
M
S
---
T
M
K
T
G
---
K
V
Y
--
Y
R
P
G
Y
V
Q
T
-
G
R
A
F
F
K
L
K
V
Q
--
G
K
G
G
H
G
-
S
-
S
-
P
-
H
-
M
A
N
D
A
I
V
A
G
S
Y
F
V
T
A
L
Q
T
V
V
S
R
R
L
-------------------------------
S
P
-------------------
F
----
E
T
G
V
V
T
I
G
S
F
D
G
K
---
G
-
Q
F
N
V
I
K
D
V
V
E
I
E
G
D
V
R
G
L
T
D
A
T
K
A
T
I
E
K
E
I
K
R
L
S
K
G
L
E
D
M
Y
----
G
V
-
T
C
T
L
E
Y
N
----
D
-
D
Y
-
P
--
A
---
L
--
Y
---
N
--
D
P
-
E
F
T
E
Y
V
A
K
T
L
K
E
A
N
L
D
F
G
V
E
--
M
----
C
--
E
P
Q
P
P
S
E
D
-
F
A
Y
Y
A
-
K
------
E
R
P
S
A
----
F
I
Y
T
G
A
A
V
E
N
G
E
I
Y
P
H
H
H
-
P
--
K
F
N
I
----
S
E
K
S
--
L
L
I
S
A
E
---
A
V
G
T
V
V
L
D
Y
L
K
----
18
PsiBlast_CBE
99.04
98%
-94
- C3 -
4EWT
4
?
D:
[1-389]
M
N
Q
Q
L
I
E
T
L
K
--
S
K
E
--
G
K
M
I
E
I
R
R
Y
L
----------
H
Q
H
P
E
L
S
F
H
----------
E
---
D
E
T
A
K
Y
I
A
E
F
Y
K
G
K
---
D
V
E
V
-
E
T
--
N
------------------------------------
V
--------------------
G
--
P
R
G
I
K
V
T
I
D
S
G
-
K
-
P
-
G
K
T
L
A
I
R
A
D
F
D
A
L
P
I
T
E
D
-------------------------------
T
-
G
--
L
S
F
A
S
Q
----
N
-
K
G
-
V
M
H
A
C
G
H
-------
D
A
H
T
A
Y
M
L
V
L
A
E
T
L
A
E
M
K
D
S
F
T
G
K
V
V
V
I
H
Q
P
A
E
E
-
V
-----
P
P
G
G
A
K
--
T
-
M
I
E
N
G
V
--
L
D
---------------------
G
V
D
H
V
-------------
L
G
V
H
V
M
S
---
T
M
K
T
G
---
K
V
Y
--
Y
R
P
G
Y
V
Q
T
-
G
R
A
F
F
K
L
K
V
Q
--
G
K
G
G
H
G
-
S
-
S
-
P
-
H
-
M
A
N
D
A
I
V
A
G
S
Y
F
V
T
A
L
Q
T
V
V
S
R
R
L
-------------------------------
S
P
-------------------
F
----
E
T
G
V
V
T
I
G
S
F
D
G
K
---
G
-
Q
F
N
V
I
K
D
V
V
E
I
E
G
D
V
R
G
L
T
D
A
T
K
A
T
I
E
K
E
I
K
R
L
S
K
G
L
E
D
M
Y
----
G
V
-
T
C
T
L
E
Y
N
----
D
-
D
Y
-
P
--
A
---
L
--
Y
---
N
--
D
P
-
E
F
T
E
Y
V
A
K
T
L
K
E
A
N
L
D
F
G
V
E
--
M
----
C
--
E
P
Q
P
P
S
E
D
-
F
A
Y
Y
A
-
K
------
E
R
P
S
A
----
F
I
Y
T
G
A
A
V
E
N
G
E
I
Y
P
H
H
H
-
P
--
K
F
N
I
----
S
E
K
S
--
L
L
I
S
A
E
---
A
V
G
T
V
V
L
D
Y
L
K
----
20
PsiBlast_CBE
96.24
98%
-96
- C3 -
4EWT
4
?
B:
[1-386]
M
N
Q
Q
L
I
E
T
L
K
--
S
K
E
--
G
K
M
I
E
I
R
R
Y
L
----------
H
Q
H
P
E
L
S
F
H
----------
E
---
D
E
T
A
K
Y
I
A
E
F
Y
K
G
K
---
D
V
E
V
-
E
T
--
N
------------------------------------
V
--------------------
G
--
P
R
G
I
K
V
T
I
D
S
G
-
K
-
P
-
G
K
T
L
A
I
R
A
D
F
D
A
L
P
I
T
E
D
-------------------------------
T
-
G
--
L
S
F
A
S
Q
----
N
-
K
G
-
V
M
H
A
C
G
H
-------
D
A
H
T
A
Y
M
L
V
L
A
E
T
L
A
E
M
K
D
S
F
T
G
K
V
V
V
I
H
Q
P
A
E
E
-
V
-----
P
P
G
G
A
K
--
T
-
M
I
E
N
G
V
--
L
D
---------------------
G
V
D
H
V
-------------
L
G
V
H
V
M
S
---
T
M
K
T
G
---
K
V
Y
--
Y
R
P
G
Y
V
Q
T
-
G
R
A
F
F
K
L
K
V
Q
--
G
K
G
G
H
G
-
S
-
S
-
P
-
H
-
M
A
N
D
A
I
V
A
G
S
Y
F
V
T
A
L
Q
T
V
V
S
R
R
L
-------------------------------
S
P
-------------------
F
----
E
T
G
V
V
T
I
G
S
F
D
G
K
---
G
-
Q
F
N
V
I
K
D
V
V
E
I
E
G
D
V
R
G
L
T
D
A
T
K
A
T
I
E
K
E
I
K
R
L
S
K
G
L
E
D
M
Y
----
G
V
-
T
C
T
L
E
Y
N
----
D
-
D
Y
-
P
--
A
---
L
--
Y
---
N
--
D
P
-
E
F
T
E
Y
V
A
K
T
L
K
E
A
N
L
-------
M
----
C
--
E
P
Q
P
P
S
E
D
-
F
A
Y
Y
A
-
K
------
E
R
P
S
A
----
F
I
Y
T
G
A
A
V
------
P
H
H
H
-
P
--
K
F
N
I
----
S
E
K
S
--
L
L
I
S
A
E
---
A
V
G
T
V
V
L
D
-------
3
PsiBlast_PDB
74.79
32%
-86
- C3 -
1XMB
-
ILL2_ARATH
A:
[37-424]
---
K
L
L
E
F
A
K
--
S
P
E
V
F
D
W
M
V
K
I
R
R
K
I
----------
H
E
N
P
E
L
G
Y
E
----------
E
---
L
E
T
S
K
L
I
R
S
E
L
E
L
I
---
G
I
K
Y
-
R
Y
--
P
------------------------------------
V
--------------------
A
--
I
T
G
V
I
G
Y
I
G
T
G
-
E
-
P
--
P
F
V
A
L
R
A
D
M
D
A
L
P
I
Q
E
G
-------------------------------
V
-
E
--
W
E
H
K
S
K
----
I
-
A
G
-
K
M
H
A
C
G
H
-------
D
G
H
V
T
M
L
L
G
A
A
K
I
L
H
E
H
R
H
H
L
Q
G
T
V
V
L
I
F
Q
P
A
E
E
-------
G
L
S
G
A
K
--
K
-
M
R
E
E
G
A
--
L
K
---------------------
N
V
E
A
I
-------------
F
G
I
H
L
S
A
---
R
I
P
F
G
---
K
A
A
--
S
R
A
G
S
F
L
A
-
G
A
G
V
F
E
A
V
I
T
--
G
K
--------------
T
I
D
P
V
V
A
A
S
S
I
V
L
S
L
Q
Q
L
V
S
R
E
T
-------------------------------
D
P
-------------------
L
----
D
S
K
V
V
T
V
S
K
V
N
------------
P
D
S
I
T
I
G
G
T
L
R
A
F
T
G
F
T
Q
--
L
Q
Q
R
V
K
E
V
I
T
K
Q
A
A
V
H
R
C
N
A
S
V
-
N
L
T
P
N
G
R
----
E
-
P
M
-
P
--
P
---
T
--
V
---
N
--
N
K
-
D
L
Y
K
Q
F
K
K
V
V
R
D
L
L
G
Q
E
A
F
V
--
E
----
A
--
A
P
V
M
G
S
E
D
-
F
S
Y
F
A
-
E
------
T
I
P
G
H
----
F
S
L
L
G
M
Q
D
E
T
N
G
Y
A
S
S
H
S
-
P
--
L
Y
R
I
----
N
E
D
V
--
L
P
Y
G
A
A
---
I
H
A
S
M
A
V
Q
Y
L
K
----
4
PsiBlast_PDB
74.61
32%
-84
- C3 -
2Q43
-
ILL2_ARATH
A:
[16-403]
---
K
L
L
E
F
A
K
--
S
P
E
V
F
D
W
M
V
K
I
R
R
K
I
----------
H
E
N
P
E
L
G
Y
E
----------
E
---
L
E
T
S
K
L
I
R
S
E
L
E
L
I
---
G
I
K
Y
-
R
Y
--
P
------------------------------------
V
--------------------
A
--
I
T
G
V
I
G
Y
I
G
T
G
-
E
-
P
--
P
F
V
A
L
R
A
D
M
D
A
L
P
I
Q
E
G
-------------------------------
V
-
E
--
W
E
H
K
S
K
----
I
-
A
G
-
K
M
H
A
C
G
H
-------
D
G
H
V
T
M
L
L
G
A
A
K
I
L
H
E
H
R
H
H
L
Q
G
T
V
V
L
I
F
Q
P
A
E
E
-------
G
L
S
G
A
K
--
K
-
M
R
E
E
G
A
--
L
K
---------------------
N
V
E
A
I
-------------
F
G
I
H
L
S
A
---
R
I
P
F
G
---
K
A
A
--
S
R
A
G
S
F
L
A
-
G
A
G
V
F
E
A
V
I
T
--
G
K
--------------
T
I
D
P
V
V
A
A
S
S
I
V
L
S
L
Q
Q
L
V
S
R
E
T
-------------------------------
D
P
-------------------
L
----
D
S
K
V
V
T
V
S
K
V
N
------------
P
D
S
I
T
I
G
G
T
L
R
A
F
T
G
F
T
Q
--
L
Q
Q
R
V
K
E
V
I
T
K
Q
A
A
V
H
R
C
N
A
S
V
-
N
L
T
P
N
G
R
----
E
-
P
M
-
P
--
P
---
T
--
V
---
N
--
N
K
-
D
L
Y
K
Q
F
K
K
V
V
R
D
L
L
G
Q
E
A
F
V
--
E
----
A
--
A
P
V
M
G
S
E
D
-
F
S
Y
F
A
-
E
------
T
I
P
G
H
----
F
S
L
L
G
M
Q
D
E
T
N
G
Y
A
S
S
H
S
-
P
--
L
Y
R
I
----
N
E
D
V
--
L
P
Y
G
A
A
---
I
H
A
S
M
A
V
Q
Y
L
K
----
22
HHSearch
73.34
33%
-83
- C3 -
1XMB
-
ILL2_ARATH
A:
[37-427]
---
K
L
L
E
F
A
K
S
P
E
V
F
--
D
W
M
V
K
I
R
R
K
I
----------
H
E
N
P
E
L
G
Y
E
----------
E
---
L
E
T
S
K
L
I
R
S
E
L
E
L
I
---
G
I
K
Y
-
R
Y
--
P
------------------------------------
V
--------------------
A
--
I
T
G
V
I
G
Y
I
G
T
--
G
-
E
-
P
P
F
V
A
L
R
A
D
M
D
A
L
P
I
Q
E
G
VEW----------------------------
E
-
H
--
K
S
K
-------
I
-
A
G
-
K
M
H
A
C
G
H
-------
D
G
H
V
T
M
L
L
G
A
A
K
I
L
H
E
H
R
H
H
L
Q
G
T
V
V
L
I
F
Q
P
A
E
E
-
G
-----
L
-
S
G
A
K
--
K
-
M
R
E
E
G
A
--
L
K
---------------------
N
V
E
A
I
-------------
F
G
I
H
L
S
A
---
R
I
P
F
G
---
K
A
A
S
R
A
G
S
F
--
L
A
-
G
A
G
V
F
E
A
V
I
T
--
G
K
--------------
T
I
D
P
V
V
A
A
S
S
I
V
L
S
L
Q
Q
L
V
S
R
E
T
-------------------------------
D
P
-------------------
L
----
D
S
K
V
V
T
V
S
K
V
N
------------
P
D
S
I
T
I
G
G
T
L
R
A
F
T
G
F
T
--
Q
L
Q
Q
R
V
K
E
V
I
T
K
Q
A
A
V
H
----
R
C
-
N
A
S
V
N
L
T
P---
N
G
R
E
-
P
MP
P
---
T
--
V
---
N
--
N
K
-
D
L
Y
K
Q
F
K
K
V
V
R
D
L
---
L
G
Q
E
A-
F
----
V
E
A
A
P
V
M
G
S
E
D
-
F
S
Y
F
A
-
E
------
T
I
P
G
H
----
F
S
L
L
G
M
Q
D
E
T
N
G
Y
A
S
S
H
S
-
P
--
L
Y
R
I
----
N
E
D
V
--
L
P
Y
G
A
A
---
I
H
A
S
M
A
V
Q
Y
L
K
E
K
A
-
42
Fugue
72.02
30%
-76
- C3 -
1XMB
-
ILL2_ARATH
A:
[37-428]
-
K
L
L
E
F
A
K
S
P
--
E
V
F
--
D
W
M
V
K
I
R
R
K
I
----------
H
E
N
P
E
L
G
Y
E
----------
E
---
L
E
T
S
K
L
I
R
S
E
L
E
L
I
---
G
I
K
Y
-
R
Y
--
P
------------------------------------
V
--------------------
A
--
I
T
G
V
I
G
Y
I
G
T
G
---
E
-
P
P
F
V
A
L
R
A
D
M
D
A
L
P
I
Q
E
G
-------------------------------
V
-
E
--
W
E
H
K
S
K
----
I
-
A
G
-
K
M
H
A
C
G
H
-------
D
G
H
V
T
M
L
L
G
A
A
K
I
L
H
E
H
R
H
H
L
Q
G
T
V
V
L
I
F
Q
P
A
E
E
-------
G
L
S
G
A
K
--
K
-
M
R
E
E
G
A
--
L
K
---------------------
N
V
E
A
I
-------------
F
G
I
H
L
S
A
---
R
I
P
F
G
---
K
A
A
--
S
R
A
G
S
F
L
A
-
G
A
G
V
F
E
A
V
I
T
--
G
K
T
--------------
I
D
P
V
V
A
A
S
S
I
V
L
S
L
Q
Q
L
V
S
R
E
T
-------------------------------
D
P
-------------------
L
----
D
S
K
V
V
T
V
S
K
V
N
------------
P
D
S
I
T
I
G
G
T
L
R
A
F
T
G
--
F
T
Q
L
Q
Q
R
V
K
E
V
I
T
K
Q
A
A
V
H
----
R
C
-
N
A
S
V
N
L
T
PNGR
E
-
P
M
-
P
--
P
---
T
--
V
---
N
--
N
K
-
D
L
Y
K
Q
F
K
K
V
V
R
D
L
L
G
Q
E
A
F
V
--
E
----
A
--
A
P
V
M
G
S
E
D
-
F
S
Y
F
A
-
E
------
T
I
P
G
H
----
F
S
L
L
G
M
Q
D
E
T
N
G
Y
A
S
S
H
S
-
P
--
L
Y
R
I
----
N
E
D
V
--
L
P
Y
G
A
A
---
I
H
A
S
M
A
V
Q
Y
L
K
E
K
A
S
21
HHSearch
72.00
33%
-80
- C3 -
1YSJ
2
YXEP_BACSU
A:
[26-402]
-------
A
D
K
--
A
F
H
--
T
R
L
I
N
M
R
R
D
L
----------
H
E
H
P
E
L
S
F
Q
----------
E
---
V
E
T
T
K
K
I
R
R
W
L
E
E
E
---
Q
I
E
I
-
L
D
V
-
P
------------------------------------
Q
--------------------
L
--
K
T
G
V
I
A
E
I
K
G
--
R
-
E
D
G
P
V
I
A
I
R
A
D
I
D
A
L
P
I
Q
E
Q
-------------------------------
T
-
N
--
L
P
F
A
S
K
----
V
-
D
G
-
T
M
H
A
C
G
H
D
F
H
----
T
A
S
I
I
G
T
A
M
L
L
N
Q
R
---
R
A
E
L
K
G
T
V
R
F
I
F
Q
P
A
E
E
-
I
-----
A
-
A
G
A
R
--
K
-
V
L
E
A
G
V
--
L
N
---------------------
G
V
S
A
I
-------------
F
G
M
H
N
K
P
---
D
L
P
V
G
---
T
I
G
--
V
K
E
G
P
L
M
A
-
S
V
D
R
F
E
I
V
I
K
--
G
K
-------------
N
S
I
D
P
I
A
A
A
G
Q
I
I
S
G
-------------------------------------------------------------
L
----
Q
N
A
V
V
S
I
T
R
V
Q
A
----
G
T
S
W
N
V
I
P
D
Q
A
E
M
E
G
T
V
R
T
F
Q
K
E
A
R
Q
A
V
P
E
H
M
R
R
V
A
E
G
I
A
A
G
Y
----
G
A
-
Q
A
E
F
K
W
F
----
P
-
Y
L
-
P
--
S
---
V
--
Q
---
N
--
D
G
-
T
F
L
N
A
A
S
E
A
A
A
R
----
L
G
Y
Q
T
V
H
----
A
--
E
Q
S
P
G
G
E
D
-
F
A
L
Y
Q
-
E
------
K
I
P
G
F
----
F
V
W
M
G
T
N
G
T
----
E
E
W
H
H
-
P
--
A
F
T
L
----
D
E
E
A
--
L
T
V
A
S
Q
---
Y
F
A
E
L
A
V
I
V
L
E
T
---
2
PsiBlast_PDB
71.72
33%
-72
- C3 -
1YSJ
2
YXEP_BACSU
A:
[28-403]
---------
K
--
A
F
H
--
T
R
L
I
N
M
R
R
D
L
----------
H
E
H
P
E
L
S
F
Q
----------
E
---
V
E
T
T
K
K
I
R
R
W
L
E
E
E
---
Q
I
E
I
L
D
V
--
P
------------------------------------
Q
--------------------
L
--
K
T
G
V
I
A
E
I
K
G
R
-
E
-
D
-
G
P
V
I
A
I
R
A
D
I
D
A
L
P
I
Q
E
Q
-------------------------------
T
-
N
--
L
P
F
A
S
K
----
V
-
D
G
-
T
M
H
A
C
G
H
-------
D
F
H
T
A
S
I
I
G
T
A
M
L
L
N
Q
R
R
A
E
L
K
G
T
V
R
F
I
F
Q
P
A
E
E
-
I
-----
A
-
A
G
A
R
--
K
-
V
L
E
A
G
V
--
L
N
---------------------
G
V
S
A
I
-------------
F
G
M
H
N
K
P
---
D
L
P
V
G
---
T
I
G
--
V
K
E
G
P
L
M
A
-
S
V
D
R
F
E
I
V
I
K
--
G
K
-------------
N
S
I
D
P
I
A
A
A
G
Q
I
I
S
G
-------------------------------------------------------------
L
----
Q
N
A
V
V
S
I
T
R
V
Q
A
G
---
T
-
S
W
N
V
I
P
D
Q
A
E
M
E
G
T
V
R
T
F
Q
K
E
A
R
Q
A
V
P
E
H
M
R
R
V
A
E
G
I
A
A
G
Y
----
G
A
-
Q
A
E
F
K
W
F
----
P
-
Y
L
-
P
--
S
---
V
--
Q
---
N
--
D
G
-
T
F
L
N
--
A
A
S
E
A
A
A
R
L
G
Y
Q
T
V
--
H
----
A
--
E
Q
S
P
G
G
E
D
-
F
A
L
Y
Q
-
E
------
K
I
P
G
F
----
F
V
W
M
G
T
N
G
T
E
----
E
W
H
H
-
P
--
A
F
T
L
----
D
E
E
A
--
L
T
V
A
S
Q
Y
F
A
E
L
A
V
I
V
L
E
T
I
-----
26
HHSearch
67.33
27%
-68
- C3 -
3IO1
2
?
A:
[3-435]
--
L
Q
L
D
E
Y
L
R
--
Q
L
A
--
P
S
M
T
Q
W
R
R
D
F
----------
H
L
H
A
E
S
G
W
L
----------
E
---
F
R
T
A
S
K
V
A
D
I
L
D
G
L
---
G
Y
Q
L
-
A
L
GR
D
VIDADSRMGLPD
E
E
T
L
A
R
A
F
E
R
A
R
E
Q
GAPERWLPAF
E
G-------------------
G
--
F
A
G
V
V
A
T
L
D
T
G
-
R
-
P
-
G
P
T
L
A
F
R
V
D
M
D
A
L
D
L
----------------------------------------------------------
C
G
H
-------
D
G
H
T
A
I
G
L
G
L
A
H
V
L
K
Q
Y
A
A
Q
L
N
G
V
I
K
L
I
F
Q
P
A
E
E
-
G
-----
T
-
R
G
A
R
--
A
-
M
V
A
A
G
V
--
V
D
---------------------
D
V
D
Y
F
-------------
T
A
I
H
I
G
T
---
G
V
P
A
G
---
T
V
V
--
C
G
-
G
D
N
F
M
-
A
T
T
K
F
D
V
Q
F
S
--
G
V
A
A
H
A
G
G
-
K
-
P
-
E
-
D
G
R
N
A
L
L
A
A
A
Q
A
A
L
G
L
H
A
I
P
P
H
S
-----------------------------------------------------
A
----
G
A
S
R
V
N
V
G
V
M
Q
A
----
G
T
G
R
N
V
V
P
S
S
A
L
L
K
V
E
T
R
G
E
S
E
A
I
N
Q
Y
V
F
E
R
A
Q
H
V
V
A
G
A
A
A
M
Y
----
E
A
-
R
Y
E
L
R
M
M
----
G
-
A
A
-
T
--
A
---
S
--
A
---
P
--
S
P
-
A
W
V
D
Y
L
R
E
Q
A
A
R
V
---
P
G
V
Q
--
Q
AVD
R
I
--
A
A
P
A
G
S
E
D
-
A
T
L
M
M
-
A
R
V
Q
A
R
G
G
L
A
S
-----
Y
M
I
F
G
T
E
L
------------------------
D
E
SV
M
A
V
A
V
E
---
T
L
A
R
V
A
L
N
F
P
W
Q
R
--
34
HHSearch
63.99
22%
-67
- C3 -
3RAM
14
?
A:
[3-376]
E
K
Q
Q
I
L
D
Y
I
E
--
T
N
K
--
Y
S
Y
I
E
I
S
H
R
I
----------
H
E
R
P
E
L
G
N
E
----------
E
---
I
F
A
S
R
T
L
I
D
R
L
K
E
H
---
D
F
E
I
-
E
T
E-
I
------------------------------------
A
G-------------------
H
--
A
T
G
F
I
A
T
Y
D
S
G
-
L
-
D
-
G
P
A
I
G
F
L
A
E
Y
D
A
L
P
G
L
G
-------------------------------------
H
A
C
---------
G
H
-
N
I
I
G
-------------
T
A
S
V
L
G
A
-
I
G
L
K
Q
V
I
D
Q
I
G
G
K
V
V
V
L
G
C
P
A
E
E
-
G
-----
G
E
N
G
S
A
K
A
S
-
Y
V
K
A
G
V
--
I
D
---------------------
Q
I
D
I
A
-------------
L
M
I
H
P
G
N
-----
E
-
T
---
Y
K
T
----
I
D
--
T
L
-
A
V
D
V
L
D
V
K
F
Y
--
G
K
S
A
H
A
-
S
-
E
N
A
-
D
-
E
A
L
N
A
L
D
A
M
I
S
Y
F
N
G
V
A
Q
L
R
Q
H
-
I
-------------------------------
K
-------------------------
K
D
Q
R
V
H
G
V
I
L
D
G
----
G
K
A
A
N
I
I
P
D
Y
T
H
A
R
F
Y
T
R
A
M
T
R
K
E
L
D
I
L
T
E
K
V
N
Q
I
A
R
G
A
A
I
Q
T
----
G
C
-
D
Y
E
F
G
P
I
Q---
N
-
G
V
-
N
--
E
---
F
--
I
---
K
--
T
P
-
K
L
D
D
L
F
A
K
Y
A
E
E
----
V
G
E
A
V
I
D
----
D
--
D
F
G
Y
G
S
T
D
-
T
G
N
V
S
-
H
------
V
V
P
T
I
H
P
--
H
I
K
I
G
S
R
N
-----
L
V
G
H
T
-
H
R
F
R
E
A
A
A
S
V
H
G
D
E
A
--
L
I
K
G
A
K
---
I
M
A
L
M
G
L
E
L
I
T
N
Q
--
25
HHSearch
60.38
17%
-61
- C3 -
3PFO
8
?
A:
[14-431]
-
T
Q
S
L
R
A
A
V
D
--
R
N
F
--
N
D
Q
V
A
F
L
Q
R
M
----------
V
Q
F
R
S
V
R
G
E
----------
E
---
A
P
Q
Q
E
W
L
A
Q
Q
F
A
D
R
---
G
Y
K
V
-
D
T
F
-
S
------------------------------------
L
ADVDIASHPKAAPMDTIDPA
G
--
S
M
Q
V
V
A
T
A
D
S
--
D
-
G
K
G
R
S
L
I
L
Q
G
H
I
D
V
V
P
E
G
P
V
DLW----------------------------
S
-
D
--
P
P
Y
E
A
K
----
V
R
D
G
-
W
M
I
G
R
G
A
QDM----
K
G
G
V
S
A
M
I
F
A
L
D
A
I
R
T
A
G
Y
A
P
D
A
R
V
H
V
Q
T
V
T
E
E
E
-
S
-----
T
G
N
G
A
L
--
S
T
L
M
R
-
G
---
Y
----------------------
R
A
D
A
C
-------------
L
I
P
E
P
T
G
-------
H
---
T
L
T
--
R
--
A
--
Q
V
-
G
A
V
W
F
R
L
R
V
R
--
G
T
P
V
H
V
-
A
-
Y
-
S
-
E
-
T
G
T
S
A
I
L
S
A
M
H
L
I
R
A
F
E
E
Y
T
K
E
L
N
A
Q
AVR--------------------------
D
P
W------------------
F
GQVK
N
P
I
K
F
N
V
G
I
I
K
G
----
G
D
W
A
S
S
T
A
A
W
C
E
L
D
C
R
L
G
L
L
T
G
D
T
P
Q
E
A
M
R
G
I
E
K
C
L
A
D
A
Q
A
T
D
S
F
L
S
E
N
-
P
A
E
L
V
W
S
G---
F
-
Q
A
-
D
--
P
---
A
V
C
E
---
P
--
G
G
-
V
A
E
D
V
L
T
A
A
H
K
A
A
---
F
N
A
P
L
-
D
----
A
--
R
L
S
T
A
V
N
D
-
T
R
Y
Y
S
V
D
Y-----
G
I
P
A
L
----
C
--
Y
G
P
Y
G
-----
Q
G
P
H
A
-
F
--
D
E
R
I
----
D
L
E
S
--
L
R
K
T
T
L
---
S
I
A
L
F
V
A
E
W
C
G
L
R
--
41
HHSearch
59.03
17%
-72
- C3 -
3N5F
3
AMAB2_GEOSE
A:
[3-407]
-------------
Q
G
--
E
R
L
W
Q
R
L
M
E
L
G
E
VGKQPSG
G
V
T
R
L
S
F
T
A
E
----------
E
---
R
R
A
K
D
L
V
A
S
Y
M
R
E
A
---
G
L
F
V
-
Y
E
---------------------------------------
D
--------------------
A
--
A
G
N
L
I
G
R
K
E
G
T
-
N
-
P
D
A
T
V
V
L
V
G
S
H
L
D
S
V
Y
N
G
G
--------------------------------------
C
F
--------------
D
G
----------
P
L
G
V
L
A
G
V
E
V
V
Q
T
M
N
E
H
G
V
V
T
H
H
P
I
E
V
V
A
F
T
D
E
E
-
G
ARFRF
G
M
I
G
S
R
--
A
-
M
A
G
T
L
P
--
P
E
A
L
E
CRDAEGIS
L
A
E
A
M
K
Q
A
GL
D
P
D
R
L
PQAARKPGTVK
A
Y
V
E
L
H
I
E
Q
GR
V
L
E
E
T
G
LP
V
G
I
V
--
T
--
G
--
I
A
-
G
L
I
W
V
K
F
T
I
E
--
G
K
A
E
H
A
-
G
-
A
T
P
M
S
-
L
R
R
D
P
M
A
A
A
A
Q
I
I
I
V
I
E
E
E
A
R
R
------------------------------------------------------
T
----
G
T
T
V
G
T
V
G
Q
L
H
V
Y
---
P
G
G
I
N
V
I
P
E
R
V
E
F
V
L
D
L
R
D
L
K
A
E
V
R
D
Q
V
W
K
A
I
A
V
R
A
E
T
I
A
K
E
R
----
N
V
-
R
V
T
T
E
R
L
----
Q
-
E
M
-
P
--
P
---
V
--
L
---
C
--
S
D
-
E
V
K
R
A
A
E
A
A
C
Q
K
----
L
G
Y
P
S
-
F
----
W
--
L
P
S
G
A
A
H
D
-
S
V
Q
L
A
-
P
------
I
C
P
I
G
-----
M
I
F
V
R
S
Q
D
----
G
V
S
H
S
-
P
--
A
E
W
S
----
T
K
E
D
--
C
A
A
G
A
E
---
V
L
Y
H
T
V
W
Q
L
A
Q
----
24
HHSearch
58.38
19%
-63
- C3 -
3GB0
7
?
A:
[3-372]
------------
I
N
Q
--
E
R
L
V
N
E
F
M
E
L
----------
V
Q
V
D
S
E
T
K
F
----------
E
---
A
E
I
C
K
V
L
T
K
K
F
T
D
L
---
G
V
E
V
-
F
E
D
-
D
TMAVT-------------------------------
G
H-------------------
G
--
A
G
N
L
I
C
T
L
P
A
T
-
K
-
D
G
V
D
T
I
Y
F
T
S
H
M
D
T
V
V
P
G
--------------------------------------
N
G
I
K
P
S
----
I
K
D
G
-
Y
I
V
S
D
G
T
TILGADD
K
A
G
L
A
S
M
F
E
A
I
R
V
L
K
E
K
N
I
-
P
H
G
T
I
E
F
I
I
T
V
G
E
E
-
S
-----
G
L
V
G
A
K
--
A
-
L
D
R
E
R
I
-------------------------
T
A
K
Y
G
-------------
Y
A
L
D
S
D
G
-----
K
V
G
---
E
I
V
--
V
A
----
A
P
-
T
Q
A
K
V
N
A
I
I
R
--
G
K
T
A
H
A
-
G
V
A
-
P
-
E
-
K
G
V
S
A
I
T
I
A
A
K
A
I
A
K
M
P
L
G
R
I
-------------------------------------------------------
D
----
S
E
T
T
A
N
I
G
R
F
E
G
----
G
T
Q
T
N
I
V
C
D
H
V
Q
I
F
A
E
A
R
S
L
I
N
E
K
M
E
A
Q
V
A
K
M
K
E
A
F
E
T
T
A
K
E
M
----
G
G
-
H
A
D
V
E
V
N
----
V
-
M
Y
-
P
--
G
---
F
--
K
F
A
-
D
--
G
D
-
H
V
V
E
V
A
K
R
A
A
E
K
----
I
G
R
T
P
-
S
----
L
--
H
Q
S
G
G
G
S
D
-
A
N
V
I
A
-
G
H
-----
G
I
P
T
V
----
N
L
--
A
V
G
Y
-----
E
E
I
H
T
-
T
--
N
E
K
I
----
P
V
E
E
--
L
A
K
T
A
E
---
L
V
V
A
I
I
E
E
V
A
-----
40
HHSearch
57.85
15%
-70
- C3 -
3IFE
7
PEPT_BACAN
A:
[19-432]
-----
Y
F
Q
S
N
--
A
M
K
--
E
E
L
I
E
R
F
T
R
Y
----------
V
K
I
D
T
Q
S
N
E
DSHTVPTT
P
G
Q
---
I
E
F
G
K
L
L
V
E
E
L
K
E
V
---
G
L
T
E
-
V
T
--
M
------------------------------------
D
--------------------
D
--
N
G
Y
V
M
A
T
L
P
A
N
T
D
-
K
D
V
P
V
I
G
F
L
A
H
L
D
T
A
T
D
F
T
G
KN
V
K
P
Q
I
H
E
NFDGNAITLNEELN
I
V
L
T
PEQF
P
E
L
--
P
S
Y
K
G
H
T
I
I
T
T
-
D
G
T
T
L
L
G
A
D
D
-------
K
A
G
L
T
E
I
M
V
A
M
N
Y
L
I
H
N
P
Q
I
K
H
G
K
I
R
V
A
F
T
P
D
E
E
-
I
-----
G
R
-
G
P
A
--
H
-
F
D
V
E
A
---
F
----------------------
G
A
S
F
A
-------------
Y
M
M
D
G
G
------
P
L
G
---
G
L
E
--
Y
--
E
--
S
F
-
N
A
A
G
A
K
L
T
F
N
--
G
T
N
T
H
P
-
G
-
T
-
A
K
N
-
K
M
R
N
A
T
K
L
A
M
E
F
N
G
H
L
P
V
E
E
A
P
E
Y
-------------------------------
T
E
-------------------
G
----
Y
E
G
F
Y
H
-----
L
----
L
-
S
L
N
G
D
V
E
Q
S
K
A
Y
Y
I
I
R
D
F
D
R
K
N
F
E
A
R
K
N
T
I
E
N
I
V
K
Q
M
Q
E
K
Y
----
G
Q
D
A
V
V
L
E
M
N
----
D
-
Q
Y
Y
N
--
M
L
E
K
I
--
E
---
P
--
V
R
-
E
I
V
D
I
A
Y
E
A
M
K
S
----
L
N
I
E
P
-
N
----
I
--
H
P
I
R
G
G
T
D
-
G
S
Q
L
S
-
Y
M
-----
G
L
P
T
P
----
N
I
--
F
T
G
G
-----
E
N
Y
H
G
-
K
--
F
E
Y
V
----
S
V
D
V
--
M
E
K
A
V
Q
---
V
I
I
E
I
A
R
R
F
E
E
----
6
PsiBlast_PDB
57.78
27%
-71
- C3 -
3RAM
14
?
A:
[5-274]
--
Q
Q
I
L
D
Y
I
E
--
T
N
K
--
Y
S
Y
I
E
I
S
H
R
I
----------
H
E
R
P
E
L
G
N
E
----------
E
---
I
F
A
S
R
T
L
I
D
R
L
K
E
H
---
D
F
E
I
-
E
T
--
E
------------------------------------
I
--------------------
A
GH
A
T
G
F
I
A
T
Y
D
S
G
-
L
-
D
-
G
P
A
I
G
F
L
A
E
Y
D
A
L
P
-----------------------------------------------------
G
-
L
G
H
A
C
G
H
-------
N
I
I
G
T
A
S
V
L
G
A
I
G
L
K
Q
V
I
D
Q
I
G
G
K
V
V
V
L
G
C
P
A
E
E
G
G
-----
E
N
G
S
A
K
--
A
S
Y
V
K
A
G
V
--
I
D
---------------------
Q
I
D
I
A
-------------
L
M
I
H
---------
P
G
---
N
E
T
--
Y
K
T
--
I
D
T
L
A
V
D
V
L
D
V
K
F
Y
--
G
K
S
A
H
A
-
S
-
E
-
N
----
A
D
E
A
L
N
A
L
D
A
M
I
S
Y
F
N
G
V
A
Q
L
R
Q
-------------------------------
H
I
-------------------
K
----
K
D
Q
R
V
H
G
V
I
L
D
G
G
---
K
-
A
A
N
I
I
P
D
Y
T
H
A
R
F
Y
T
R
A
M
T
R
K
E
L
D
I
L
T
E
K
V
N
Q
I
A
R
G
A
A
I
Q
T
----
G
---
C
D
Y
E
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
57.61
18%
-55
- C3 -
3RZA
10
?
A:
[19-394]
--------
G
M
--
I
N
E
--
Q
R
L
L
N
T
F
L
E
L
----------
V
Q
I
D
S
E
T
G
N
----------
E
---
S
T
I
Q
P
I
L
K
E
K
F
I
A
L
---
G
L
D
V
-
K
E
D
-
E
------------------------------------
A
AKHPKL--------------
G
--
A
N
N
L
V
C
T
M
N
S
T
-
I
E--
V
P
K
L
Y
L
T
S
H
M
D
T
V
V
P
A
I
--------------------------------
N
-
V
--
K
P
I
V
K
D
------
D
G
-
Y
I
Y
S
D
G
T
TILGADD
K
A
G
L
A
A
M
L
E
V
L
Q
V
I
K
E
Q
Q
I
-
P
H
G
Q
I
Q
F
V
I
T
V
G
E
E
-
S
-----
G
L
I
G
A
K
--
E
-
L
N
S
E
L
---
L
----------------------
D
A
D
F
G
-------------
Y
A
I
D
A
S
A
-----
D
V
G
---
T
T
V
--
V
G
----
A
P
-
T
Q
M
L
I
S
A
K
I
I
--
G
K
T
A
H
A
-
S
-
T
-
P
-
K
-
E
G
V
S
A
I
N
I
A
A
K
A
I
S
R
M
K
L
G
Q
V
-------------------------------------------------------
D
----
E
I
T
T
A
N
I
G
K
F
H
G
----
G
S
A
T
N
I
V
A
D
E
V
I
L
E
A
E
A
R
S
H
D
P
E
R
I
K
T
Q
V
K
H
M
T
D
V
F
E
T
T
A
S
E
L
----
G
G
-
K
A
E
V
T
V
E
----
Q
-
S
Y
-
P
--
G
---
F
--
K
I
N-
D
--
N
E
-
A
V
V
K
I
A
Q
E
S
A
R
N
----
L
G
L
S
A-
N
----
T
--
I
I
S
G
G
G
S
D
-
G
S
I
I
N
-
T
F
-----
G
I
P
S
V
----
I
L
--
G
V
G
Y
-----
E
K
I
H
T
-
T
--
N
E
R
M
----
P
I
K
S
--
L
N
L
L
A
S
---
Q
V
L
E
I
I
K
I
V
A
R
Q
---
23
HHSearch
57.60
17%
-61
- C3 -
1CG2
5
CBPG_PSES6
A:
[7-392]
-
D
N
V
L
F
Q
A
A
T
--
D
E
Q
--
P
A
V
I
K
T
L
E
K
L
----------
V
N
I
E
T
G
T
G
D
----------
A
E
G
I
A
A
A
G
N
F
L
E
A
E
L
K
N
L
---
G
F
T
V
-
T
R
S
-
K
------------------------------------
S
AGL
V
----------------
V
--
G
D
N
I
V
G
K
I
K
G
--
R
-
G
-
G
K
N
L
L
L
M
S
H
M
D
T
V
Y
L
K
G
I
L------------------------------
A
-
K
--
A
P
F
R
V
E
------
G
D
-
K
A
Y
G
P
G
I
ADD----
K
G
G
N
A
V
I
L
H
T
L
K
L
L
K
E
Y
G
V
R
D
Y
G
T
I
T
V
L
F
N
T
D
E
E
-
K
-----
G
S
F
G
S
R
--
D
-
L
I
Q
E
E
A
--
K
----------------------
L
A
D
Y
V
-------------
L
S
F
E
P
T
S
---
A
-
G
D
E
---
K
L
S
--
L
--
G
--
T
S
-
G
I
A
Y
V
Q
V
N
I
T
--
G
K
A
S
H
A
G
A
-
A
-
P
-
E
-
L
G
V
N
A
L
V
E
A
S
D
L
V
L
R
T
M
N
I
D
D
K
------------------------------------------------------
A
----
K
N
L
R
F
N
W
T
I
A
K
A
----
G
N
V
S
N
I
I
P
A
S
A
T
L
N
A
D
V
R
Y
A
R
N
E
D
F
D
A
A
M
K
T
L
E
E
R
A
Q
Q
K
K
L
-
P
----
E
A
-
D
V
K
V
I
V
T
----
R
-
G
R
-
P
--
A
---
F
--
N
AG
E
G
--
G
K
-
K
L
V
D
K
A
V
A
Y
Y
K
E
A
---
G
G
T
L
G
-
V
----
E
--
E
R
T
G
G
G
T
D
-
A
A
Y
A
A
-
L
S-----
G
K
P
V
I
----
E
-
S
L
G
L
P
G
-----
F
G
Y
H
S
D
K
--
A
E
Y
V
----
D
I
S
A
--
I
P
R
R
L
Y
---
M
A
A
R
L
I
M
D
L
G
A
G
---
36
HHSearch
56.48
13%
-61
* C3 *
3PFE
24
?
A:
[5-471]
-
P
Q
G
L
Y
D
Y
I
C
--
Q
Q
W
Q
-
E
E
I
L
P
S
L
C
D
Y
----------
I
K
I
P
N
K
S
P
H
FDAKWEEHG
Y
M
---
E
Q
A
V
N
H
I
A
N
W
C
K
S
H
APK
G
M
T
L
-
E
I
V-
R
------------------------------------
L
KN------------------
R
--
T
P
L
L
F
M
E
I
P
G
--
Q
-
I
-
D
D
T
V
L
L
Y
G
H
L
D
K
Q
P
E
M
S
G
W------------------------------
S
-
D
DL
H
P
W
K
P
V
----
L
K
N
G
-
L
L
Y
G
R
G
G
ADD----
G
Y
S
A
Y
A
S
L
T
A
I
R
A
L
E
Q
Q
G
-
L
P
Y
P
R
C
I
L
I
I
E
A
C
E
E
-
S
-----
G
S
Y
D
L
P
--
F
-
Y
I
E
L
L
K
ER
I
G
---------------------
K
P
S
L
V
-------------
I
C
L
D
S
G
A
---
G
-
N
Y
E
---
Q
L
W
--
M
T
T
S
--
L
R
-
G
N
L
V
G
K
L
T
V
E
LI
N
E
G
V
H
S
-
G
-
S
-
A
-
S
G
I
V
A
D
S
F
R
V
A
R
Q
L
I
S
R
I
E
D
E
N
T
G
E
I
KLPQLYCDIP
D
E
R
I
K
Q
A
K
Q
C
A
E
I
L
GEQVYSE
F
P
WIDSAKPVIQD
K
Q
Q
L
I
L
N
R
T
----
W
R
P
A
L
T
V
T
G
A
D
G
F
PAI
A
D
A
G
N
V
M
R
P
V
T
S
L
K
L
S
M
R
L
P
P
L
V
D
P
E
A
A
S
V
A
M
E
K
A
L
T
Q
N
P
P
-
Y
----
N
A
-
K
V
D
F
K
I
Q
----
N
G
G
S
-
K
--
G
---
W
--
N
---
A
P
L
L
S
D
W
L
A
K
A
A
S
E
A
S
M
T
Y
---
Y
D
K
P
A
-
A
----
Y
--
M
G
E
G
G
T
I
P
F
M
S
M
L
G
-
E
------
Q
F
P
K
A
QFMI
T
G
V
L
G
P
H
------
S
N
A
H
G
-
P
--
N
E
F
L
----
H
L
D
M
--
V
K
K
L
T
S
---
C
V
S
Y
V
L
Y
S
F
S
Q
K
---