@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0140: (2016-03-12 )
MSNIAFYVVSDVHGYIFPTDFTSRNQYQPMGLLLANHVIEQDRRQYDQSFKIDNGDFLQGSPFCNYLIAHSGSSQPLVDFYNQMAFDFGTLGNHEFNYGLPYLKDTLRRLNYPVLCANIYENDSTLTDNGVQYFQVGDQTVGVIGLTTQFIPHWEQPEHIQSLTFHSAFETLQQHLPEMKRHADIIVVCYHGGFEKDLENGTPTEVLTGENEGYAMLEAFSKDIDIFITGHQHRQIAERFKQTAVIQPGTRGTTVGKVVLSTDEYENVSVESCELLPVIDDSTFTIDEDDQHLRKQLEDWLDYEITTLPYDMTINHAFEARVAPHPFTNFMNYALLEKSDADVACTALFDSASGFKQVVTMRDVINNYPFPNTFKVLAVSGAKLKEAIERSAEYFDVQNDEVSVSADFLGPKPQHFNYDIYGGVSYTIHVGRPKGQRVSNMMIQGHAVDLKQTYTICVNNYRAVGGGQYDMFIDAPVVKDIQVEGAQLLIDFLSNNNLMRIPQVVDFKVEK
Atome Classification :
(20 SA)
-----.........10.......--.20-------------------..--.-----.....30.--------------------------------.......40..---..----..----..----50........60........-------70........--80........90........100.......110.......-120.-----.-.....---130.--.-----.-----.----..----.140......-.150..-.....160........170......-.180--.-.......190.......200..---.....210.......220--.......230....---..-------------------.--------------240--..-------------------......250-----------.........260.---..-.-.-..270...--.....-----------.--280-----.....-------..---290.----------......300..--.....310.......320..--.....330......-.---340--------------------.......--.----------.350---..---....------.-----.360.......370-.......-380.......390---........-400.......410-----------........420-.......430-.......440.-----.----...----..450.......460.......470----------.....-----.-..480.......490.......500--........510---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MS
N
I
A
F
Y
V
V
SDVH
G
Y
I
FP--TDF-------------------TS--R-----NQYQ
P
M
G
L
--------------------------------
L
L
A
N
H
V
I
E
Q
D
R
---
R
Q----YD----QS----FKIDNGDFLQGSP
F
C
N
Y
L
I
A-------HSGSSQ
P
L
V
D
--
F
Y
N
Q
M
A
F
D
FGTLGNHEFNYG
L
P
Y
L
K
D
T
L
R
RLNY
P
V
L
C
A
N
I-YEND-----S-TLTDN---G
V
Q
Y
--
F
-----
Q
-----V----GD----
Q
T
V
G
V
I
G
L
T
T-QFIPHW-EQ
P
E
H
I
Q
-
S
L
T
F
H
S
A
F
E
T
L
Q
Q
H
L
P
E
-
M
K
-R--H-A
D
I
I
V
V
C
YHGGFEKDLENGTPT---
E
V
LTGENE
G
Y
A
M
L
E
A
FSK--D
I
D
I
F
I
TGH
Q
H
R
Q
I
---
A
E
-------------------
R
--------------
F
-
K
--Q
T
-------------------
A
V
IQPGT-------------RG
T
T
V
G
K
V
V
LSTD---EY-E-N-VSV--ES
C
--
E
L
L
P
V-----------I--DD
S
-----
T
F
TID-------E
D
---
D
Q
H
L
----------
R
K
Q
L
E
D
W
LDY
E
--
I
T
TLPY
D
M
T
IN
H
A
FEARVAP--HP
F
T
N
F
M
N
Y
A
L
LEK-S---D----------------------A
D
V
A
C
T
A
--
L
----------FDS----AS---
G
F
K
Q
------
V
-----
V
T
M
R
D
V
I
NNYPFP
N
-
T
F
K
V
L
AV-S
G
A
K
L
K
E
A
I
E
RS----A
E
Y
F
DVQN-D
E
V
S
V
SADFLGP------------KPQHF
N
Y
D
I
YG-
G
V
S
Y
T
I
H
VGR-PKGQ
R
V
S
N
M
M
I
-----Q----GHA----VDL
K
Q
T
Y
T
I
C
V
N
N
Y
R
AVGGGQ
Y
D
M
-----------
F
IDAP-----
V
-
V
K
D
I
QVE
G
A
Q
L
L
I
D
F
LSNNN
L
M
RI---P
Q
V
V
D
F
KVEK----------
2
PsiBlast_PDB
100.00
95%
-120
- C2 -
4Q7F
3
?
A:
[18-527]
------
S
N
I
A
F
Y
V
V
S
D
V
H
G
Y
I
F
P
--
T
D
F
-------------------
T
S
--
R
-----
N
Q
Y
Q
P
M
G
L
--------------------------------
L
L
A
N
H
V
I
E
Q
D
R
---
R
Q
----
Y
D
----
Q
S
----
F
K
I
D
N
G
D
F
L
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S
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F
C
N
Y
L
I
A
-------
H
S
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S
S
Q
P
L
V
D
--
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
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N
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G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
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N
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-
Y
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N
D
-----
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-
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L
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---
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V
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Y
--
F
-----
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-----
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----
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----
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V
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T
T
-
Q
F
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P
H
W
-
E
Q
P
E
H
I
Q
-
S
L
T
F
H
S
A
F
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I
L
Q
Q
Y
L
P
E
-
M
K
-
R
--
H
-
A
D
I
I
V
V
C
Y
H
G
G
F
E
K
D
L
E
S
G
T
P
T
---
E
V
L
T
G
E
N
E
G
Y
A
M
L
E
A
F
S
K
--
D
I
D
I
F
I
T
G
H
Q
H
R
Q
I
---
A
E
-------------------
R
--------------
F
-
K
--
Q
T
-------------------
A
V
I
Q
P
G
T
-------------
R
G
T
T
V
G
R
V
V
L
S
T
D
---
E
Y
-
E
-
N
-
L
S
V
--
E
S
C
--
E
L
L
P
V
-----------
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--
D
D
S
-----
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F
T
I
D
-------
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D
---
D
Q
H
L
----------
R
K
Q
L
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D
W
L
D
Y
E
--
I
T
T
L
P
Y
D
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T
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N
H
A
F
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A
R
V
A
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--
H
P
F
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N
F
M
N
Y
A
L
L
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K
-
S
---
D
----------------------
A
D
V
A
C
T
A
--
L
----------
F
D
S
----
A
S
---
G
F
K
Q
------
V
-----
V
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
-
S
G
A
K
L
K
E
A
I
E
R
S
----
A
E
Y
F
D
V
K
N
-
D
E
V
S
V
S
A
D
F
L
E
P
------------
K
P
Q
H
F
N
Y
D
I
Y
G
-
G
V
S
Y
T
I
H
V
G
R
-
P
K
G
Q
R
V
S
N
M
M
I
-----
Q
----
G
H
A
----
V
D
L
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
G
Q
Y
D
M
-----------
Y
I
D
A
P
-----
V
-
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
---
P
Q
V
V
D
F
K
V
E
K
----------
1
PsiBlast_PDB
99.25
95%
-119
- C2 -
3QFK
4
?
A:
[18-527]
------
S
N
I
A
F
Y
V
V
S
D
V
H
G
Y
I
F
P
--
T
D
F
-------------------
T
S
--
R
-----
N
Q
Y
Q
P
M
G
L
--------------------------------
L
L
A
N
H
V
I
E
Q
D
R
---
R
Q
----
Y
D
----
Q
S
----
F
K
I
D
N
G
D
F
L
Q
G
S
P
F
C
N
Y
L
I
A
-------
H
S
G
S
S
Q
P
L
V
D
--
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
N
Y
G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
-
Y
E
N
D
-----
S
-
T
L
T
D
N
---
G
V
K
Y
--
F
-----
Q
-----
V
----
G
D
----
Q
T
V
G
V
I
G
L
T
T
-
Q
F
I
P
H
W
-
E
Q
P
E
H
I
Q
-
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
-
M
K
-
R
--
H
-
A
D
I
I
V
V
C
Y
H
G
G
F
E
K
D
L
E
S
G
T
P
T
---
E
V
L
T
G
E
N
E
G
Y
A
M
L
E
A
F
S
K
--
D
I
D
I
F
I
T
G
H
Q
H
R
Q
I
---
A
E
-------------------
R
--------------
F
-
K
--
Q
T
-------------------
A
V
I
Q
P
G
T
-------------
R
G
T
T
V
G
R
V
V
L
S
T
D
---
E
Y
-
E
-
N
-
L
S
V
--
E
S
C
--
E
L
L
P
V
-----------
I
--
D
D
S
-----
T
F
T
I
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-------
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D
---
D
Q
H
L
----------
R
K
Q
L
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W
L
D
Y
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--
I
T
T
L
P
Y
D
M
T
I
N
H
A
F
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A
R
V
A
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--
H
P
F
T
N
F
M
N
Y
A
L
L
E
K
-
S
---
D
----------------------
A
D
V
A
C
T
A
--
L
----------
F
D
S
----
A
S
---
G
F
K
Q
------
V
-----
V
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
-
S
G
A
K
L
K
E
A
I
E
R
S
----
A
E
Y
F
D
V
K
N
-
D
E
V
S
V
S
A
D
F
L
E
P
------------
K
P
Q
H
F
N
Y
D
I
Y
G
-
G
V
S
Y
T
I
H
V
G
R
-
P
K
G
Q
R
V
S
N
M
M
I
-----
Q
----
G
H
A
----
V
D
L
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
G
Q
Y
D
M
-----------
Y
I
D
A
P
-----
V
-
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
---
P
Q
V
V
D
F
K
V
E
K
----------
23
HHSearch
68.95
19%
-95
- C2 -
1HP1
7
USHA_ECOLI
A:
[7-515]
------
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
--
N
E
Y
--------------------------------
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
V
A
A
E
G
G
----
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
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F
P
L
L
S
A
N
I
-
Y
Q
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TGE--
R
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L
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--
K
---
P
W
A
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--
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-----
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-----
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----
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D
----
L
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I
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V
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G
L
T
T
-
D
D
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-
G
N
P
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Y
F
T
-
D
I
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F
R
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P
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A
K
L
V
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Q
E
-
L
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TE
K
-
P
D
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I
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A
A
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H
M
G
H
Y
D
N
G
E
H
G
---------
S
N
A
P
G
D
V
E
M
A
R
A
L
-
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
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---
C
M
AAENKKQVDYVPG
T
P
C
K
P
D
Q
--------------
Q
-
N
--
G
I
-------------------
W
I
V
Q
A
H
E
-------------
W
G
K
Y
V
G
R
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D
F
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R
---
N
G
-
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---
M
K
M
--
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Q
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L
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L
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G
----------------------
A
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F
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S
--
G
----------
G
G
I
----
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D
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--
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E
A
G
------
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-----
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
-
T
G
K
E
V
I
D
Y
L
T
A
V
----
A
Q
M
K
P
--------
D
S
G
A
Y
P
----------------------
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F
A
-
N
V
S
F
V
A
K
------
D
G
K
L
N
D
L
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-----
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----
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P
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F
N
A
T
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D
G
Y
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L
D
N
K
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-----
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-
Y
V
N
T
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F
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D
A
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A
Y
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Q
K
S
S
P
L
D
V
SVY
E
P
K
G
E
V
S
W
------------
21
HHSearch
66.07
22%
-96
- C2 -
2Z1A
4
?
A:
[28-532]
------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
--
V
E
L
-------------------
T
L
--
S
G----
E
K
T
P
V
G
G
V
--------------------------------
A
R
R
V
A
L
F
D
R
V
W
---
A
R
----
A
K
----
N
P
----
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
------------
R
G
L
A
D
R
Y
--
F
M
H
R
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R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
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F
K
V
V
S
A
N
V
-
D
A
S
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G
-
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--
A
---
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--
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-----
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----
G
G
----
E
R
V
G
I
I
G
L
T
T
-
P
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T
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E
I
-
S
N
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--
P
-
T
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A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
-
L
L
-
A
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-
G
-
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
-------------------
L
K
L
A
R
R
L
-
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
---
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
--------------
G
-
K
--
D
V
-------------------
L
V
V
Q
A
W
E
-------------
W
G
K
V
V
G
L
L
E
V
T
F
D
---
A
K
-
G
-
E
-
L
L
A
--
Y
K
G
--
E
A
L
L
M
TPE--------
A
--
A
P
E
-----
D
F
F
A
K
-------
E
A
---
L
L
A
Y
----------
A
Q
P
V
M
A
L
M
Q
Q
V
--
I
A
E
A
K
V
D
L
V
G
E
-
R
A
V
V
R
R
R
E
--
S
N
L
G
N
L
I
T
D
G
M
L
W
K
-
T
R
NA
G
----------------------
T
Q
I
A
L
Q
N
--
G
----------
G
G
I
----
R
A
S
--
I
P
K
G
------
P
-----
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
-
K
G
K
E
I
L
A
A
L
E
N
G
----
V
S
Q
W
E
N
-------
T
A
G
R
F
L
----------------------
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
-
P
A
G
S
R
V
V
R
V
E
V
-----
K
T
EKG
Y
V
P
----
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
-----------
L
K
E
A
Q
-----
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
A
---
G
L
E
G
R
I
E
V
L
N
----------
14
PsiBlast_PDB
62.45
22%
-80
- C2 -
1HP1
7
USHA_ECOLI
A:
[14-493]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------
N
--
L
K
K
KRVLY
T
P
E
I
A
-------
E
N
---
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
--
N
G
R
L
E
G
D
R
D
-----
K
V
R
F
V
Q
--
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
---
G
----------------------
A
D
F
A
V
M
----------------
S
----
G
G
---
G
I
R
D
------
S
I
E
AGD
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
-
T
G
---
K
E
V
I
----------------
D
Y
L
T
A
V
A
Q
M
---------------
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNKPGYVNTG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
22
HHSearch
61.82
21%
-86
- C2 -
3IVE
5
?
A:
[5-498]
------
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
--
Y
K
V
-------------------
P
W
IA
D
-----
G
K
R
D
I
G
G
W
--------------------------------
A
N
I
T
T
L
V
K
Q
E
K
---
A
K
----
N
K
----
A
T
----
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
L
T
------------
K
G
K
A
I
I
D
--
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
I
-
F
Y
Q
N
SSK--
S
F
W
D
--
K
---
P
Y
T
I
--
I
-----
E
-----
K
----
D
G
----
V
K
I
G
V
I
G
L
H
G
-
V
F
A
F
N
D
T
V
S
A
A
T
R
V
-
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
-
L
K
-
G
--
K
-
V
D
L
T
V
A
L
I
H
E
G
V
P
A
R
Q
S
S
M
------
D
V
R
R
A
L
D
K
D
I
Q
T
A
S
Q
V
-
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
---
P
E
-------------------
P
I
K
------------
V
-
G
--
N
T
-------------------
L
I
L
S
T
D
S
-------------
G
G
I
D
V
G
K
L
V
L
D
Y
K
---
E
K
-
P
-
H
N
F
T
V
--
K
N
F
--
E
L
K
T
I
Y
AD--------
E
--
W
K
P
-----
D
Q
Q
T
K
-------
Q
V
---
I
D
G
W
----------
N
K
K
L
D
E
V
V
Q
Q
T
--
V
A
Q
S
P
V
E
L
K
R
-----
A
Y
G
E
S
--
A
S
L
G
N
L
A
A
D
A
L
L
A
A
-
A
---
G
KN--------------------
T
Q
L
A
L
T
N
--
S
----------
G
G
I
----
R
N
E
--
I
P
A
G
------
A
-----
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
-
T
G
K
Q
L
R
S
L
M
E
H
G
----
A
S
L
S
-----------
N
G
V
L
----------------------
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
-
P
V
G
Q
R
V
I
T
L
T
L
-----
N
----
G
K
P
----
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
-----------
F
T
E
G
K
-----
A
R
N
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
T
I
T
D
---
E
Q
L
N
G
M
R
V
K
-----------
44
Fugue
58.95
17%
-79
- C2 -
2WDC
18
?
A:
[21-562]
YDLPP
Y
G
D
A
T
L
L
Y
F
S
D
L
H
G
Q
A
F
P
--
H
Y
F
M
E
P
PNLIAPKPLMGRPGYL
T
G
--
E
-----
A
I
L
R
Y
Y
G
V
ERGT
P
L
A
Y
L
L
SYVD
F
V
E
L
A
R
T
FGPIGG
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
V
E
---
A
E
----
G
G
----
K
A
----
L
V
L
D
G
G
D
T
W
T
N
S
-----
G
L
S
-------
L
L
T
R
G
E
A
V
V
R
--
W
Q
N
L
V
G
V
D
-
H
M
V
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
-
V
D
D
L
-----
F
G
D
P
L
F
P
---
A
Y
R
I
--
H
-----
R
-----
V
----
G
P
----
Y
A
L
A
V
V
G
A
S
Y
-
P
Y
V
K
V
S
-
H
P
E
S
F
T
E
-
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
-
A
R
A
E
--
G
-
A
N
A
V
V
L
L
S
H
N
G
M
Q
L
D
A
A
L
A
E
R
I
--------------------
R
--
G
I
D
L
I
L
S
G
H
T
H
D
L
T
P
R
-
P
W
-------------------
R
--------------
V
-
G
--
K
T
-------------------
W
I
V
A
G
S
A
-------------
A
G
K
A
L
M
R
V
D
L
K
L
W
---
K
--
G
-
G
-
I
A
N
--
L
R
V
--
R
V
L
P
V
-----------
L
--
A
E
H
-----
L
-----------
P
K
---
A
E
D
V
----------
E
A
F
L
K
A
Q
L
A
P
H
--
Q
D
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
K
R
D
T
LY
S
T
W
D
Q
L
V
G
E
A
V
K
A
I
Y
P
---
E
----------------------
V
E
V
V
F
S
P
AV
R
----------
W
G
T
----
T
I
---
L
P
G
Q
------
A
-----
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
-
R
G
A
Q
I
K
A
V
L
E
D
I
----
A
S
N
V
F
T
S
D
-
P
F
Y
Q
Q
G
G
D
V
S
----------------------
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
-
P
T
G
E
R
V
R
E
V
E
V
-----
G
----
G
R
P
----
L
D
P
N
R
R
Y
L
A
A
A
Y
-----
G
G
R
L
Q
R
V
-----------
G
E
A
K
P
-----
G
-
Y
E
P
R
P
--
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
---
R
P
E
P
N
V
K
V
I
G
R
N
Y
R
L
P
EVTG
26
HHSearch
57.89
25%
-94
- C2 -
3GVE
3
NTPES_BACSU
A:
[10-340]
------
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
--
Y
D
Y
-------------------
Y
S
--
D
-----
K
E
T
A
D
F
G
L
--------------------------------
A
R
T
A
Q
L
I
Q
K
H
R
---
E
Q
----
N
P
----
N
T
----
L
L
V
D
N
G
D
L
I
Q
G
N
P
L
G
E
Y
A
V
K
YQ
K
D
D
I
I
S
G
T
K
T
H
P
I
I
S
--
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
-
K
T
T
S
GE---
N
-
R
Y
--
T
---
P
Y
V
I
--
N
-----
E
K
TLID
E
NG
N
E
Q
K
----
V
K
V
G
Y
I
G
F
V
P
-
P
Q
I
M
T
W
-
D
K
K
N
L
E
G
-
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
-
M
K
-
A
E
-
G
-
A
D
V
I
I
A
L
A
H
T
G
I
E
K
Q
A
Q
S
S
---------
G
A
E
N
A
V
F
D
L
A
T
K
T
-
K
--
G
I
D
A
I
I
S
G
H
Q
H
G
L
F
---
P
S
-------------------
A
EYAGVAQFNVEKGT
I
-
N
--
G
I
-------------------
P
V
V
M
P
S
S
-------------
W
G
K
Y
L
G
V
I
D
L
K
L
E
---
K
A
-
D
-
G
S
W
K
V
A
D
S
K
G
--
S
I
E
S
I
A----------
G
NV
T
S
R
-----
N
E
T
V
T
-------
N
T
---
I
Q
Q
T
----------
H
Q
N
T
L
E
Y
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
56.75
25%
-95
- C2 -
3JYF
12
?
A:
[7-338]
------
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
--
F
D
Y
-------------------
Y
K
--
D
-----
A
A
T
E
K
F
G
L
--------------------------------
V
R
T
A
S
L
I
E
Q
A
R
---
A
E
----
V
K
----
N
S
----
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
M
A
A
K
GL----
K
E
G
D
V
H
P
V
Y
K
--
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
N
Y
G
L
D
F
L
H
K
A
L
A
G
A
K
F
P
Y
V
N
A
N
I
-
I
D
A
K
TGK--
P
-
M
F
--
T
---
P
Y
L
I
--
Q
D
T
R
V
V
D
-----
S
----
D
G
Q
I
H
T
L
R
I
G
Y
I
G
F
V
P
-
P
Q
I
M
T
W
-
D
K
A
N
L
N
G
-
K
V
T
V
N
D
I
T
E
T
A
R
K
Y
I
P
E
-
M
R
-
A
K
-
G
-
A
D
V
V
V
V
V
A
H
S
G
L
S
A
D
P
Y
Q
A
---------
M
A
E
N
-
S
V
Y
Y
L
S
Q
V
-
P
--
G
V
D
A
I
M
F
G
H
A
H
A
V
F
---
P
G
-------------------
K
DFANIKGADIAKGT
L
-
N
--
G
V
-------------------
P
A
V
M
P
G
M
-------------
W
G
D
H
L
G
V
V
D
L
V
L
N
---
N
D
-
S
G
K
-
W
Q
V
T
Q
S
K
A
--
E
A
R
P
I
YDAVAKKS---
L
--
A
A
E
-----
D
G
K
L
V
-------
S
V
---
L
K
A
D
----------
H
D
A
T
R
E
F
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
56.36
16%
-90
- C2 -
2WDC
17
?
A:
[100-552]
------------------------------------------------------------
P
I
G
G
M
--------------------------------
G
A
L
T
A
L
I
R
D
Q
K
---
A
R
V
E
A
E
G
G
----
K
A
----
L
V
L
D
G
G
D
T
W
T
N
S
G
L
S
L
L
T
------------
R
G
E
A
V
V
R
--
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
-
V
D
D
L
FGD--
P
-
L
F
--
P
---
A
Y
R
I
--
H
-----
R
-----
V
----
G
P
----
Y
A
L
A
V
V
G
A
S
Y
-
P
Y
V
K
V
S
-
H
P
E
S
F
T
E
-
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
-
A
R
-
A
E
-
G
-
A
N
A
V
V
L
L
S
H
N
G
M
Q
L
D
-------------------
A
A
L
A
E
R
I
-
R
--
G
I
D
L
I
L
S
G
H
T
H
D
L
T
---
P
R
-------------------
P
W
R
------------
V
-
G
--
K
T
-------------------
W
I
V
A
G
S
A
-------------
A
G
K
A
L
M
R
V
D
L
K
L
W
---
K
G
-
G
---
I
A
N
--
L
R
V
--
R
V
L
P
V
LAE--------
H
--
L
P
K
-----
A
E
D
V
E
-------
A
F
---
L
K
A
Q
----------
L
A
P
H
Q
D
H
L
F
T
P
--
L
A
V
S
E
T
L
L
Y
K
-----
R
D
T
L
Y
--
S
T
W
D
Q
L
V
G
E
A
V
K
A
I
-
Y
--------------------------
P
E
V
E
V
V
F
--
S
----------
P
A
V
----
R
W
G
T
T
I
L
P
G
Q
-----
A
-----
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
-
R
G
A
Q
I
K
A
V
L
E
D
I
----
A
S
N
V
F
T
S
D
-
P
F
Y
Q
Q
G
G
D
V
S
----------------------
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
-
P
T
G
E
R
V
R
E
V
E
V
-----
G
----
G
R
P
----
L
D
P
N
R
R
Y
L
A
A
A
Y
G
G
R
L
Q
------
R
-----------
V
G
E
A
K
-----
P
-
G
-
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
---
R
P
E
P
N
V
K
V
I
G
----------
45
Fugue
55.66
20%
-86
* C2 *
1USH
6
?
?:
[26-362]
YEQD
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
--
N
E
--------------------------------
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
A
E
G
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
---
P
-----
G
D
V
E
M
A
R
A
L
P
A
G
--
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
---
C
M
-------------------
A
--------------
A
-
E
--
N
K
KQVDYVPG
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
-------------
W
G
K
Y
V
G
R
A
D
F
E
F
R
---
N
--
G
-
E
-
M
K
M
--
V
N
Y
--
Q
L
I
P
V
-----------
N
--
L
K
K
-----
R
V
L
Y
T
-------
P
E
IAE
N
Q
Q
M
----------
I
S
L
L
S
P
F
Q
N
K
G
--
K
A
Q
L
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.22
23%
-69
- C2 -
1HO5
4
USHA_ECOLI
A:
[14-502]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
K
V
T
-
W
E
D
G
K
--
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
QM
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNK
P
G
Y
V
N
TG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
17
PsiBlast_PDB
55.14
23%
-73
- C2 -
4WWL
15
USHA_ECOLI
A:
[14-488]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
K
V
T
-
W
E
D
G
K
--
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
-----------
L
D
N
K
P
------------------------------------------------------
19
PsiBlast_PDB
55.04
23%
-76
- C2 -
1OIE
1
USHA_ECOLI
A:
[14-502]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
T
E
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
C
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
K
V
---------
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNKCGYVNTG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
16
PsiBlast_PDB
54.99
23%
-70
- C2 -
1USH
7
USHA_ECOLI
A:
[40-527]
--------------
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
-------------
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNKPGYVNTG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
5
PsiBlast_PDB
54.94
22%
-69
- C2 -
3IVD
4
?
A:
[6-462]
-------
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
-------------------
I
A
--
D
-----
G
K
R
D
I
G
G
W
--------------------------------
A
N
I
T
T
L
V
K
Q
E
K
---
A
K
----
N
K
----
A
T
----
W
F
F
D
A
G
D
Y
F
T
G
-
P
Y
I
S
S
L
T
-----------
K
G
K
A
I
I
D
--
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
S
-----
S
K
S
F
W
D
K
---
P
Y
T
I
--
I
-----
E
-----
K
----
D
G
----
V
K
I
G
V
I
G
L
H
G
-
V
F
A
F
N
D
-
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
-
L
K
-
G
--
K
-
V
D
L
T
V
A
L
I
H
E
G
V
P
A
R
Q
S
S
M
G
G
T
---
D
V
R
R
A
L
D
K
D
I
Q
T
A
S
Q
V
-
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
---
P
E
-------------------
P
--------------
I
-
K
V
G
N
T
-------------------
L
I
L
S
T
D
S
-------------
G
G
I
D
V
G
K
L
V
L
D
Y
K
---
E
K
P
H
-
N
-
F
T
V
--
K
N
F
--
E
L
K
T
I
-----------
Y
--
A
D
E
-----
W
-----------
K
P
---
D
Q
Q
T
----------
K
Q
V
I
D
G
W
-
N
K
K
--
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
A
Y
--
G
E
S
A
S
L
G
N
L
A
A
D
A
L
-
L
---
A
----------------------
A
A
G
K
N
T
Q
--
L
----------
A
L
T
----
N
S
---
G
G
I
R
N
E
I
P
A
G
A
-----
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
-
T
G
K
Q
L
R
S
L
M
E
H
G
----
A
S
---
L
S
N
-
G
V
L
Q
V
S
------------------
K
G
L
E
M
K
Y
D
-----------
S
S
K
-
P
V
G
Q
R
V
I
T
L
T
L
-----
N
----
G
K
P
----
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
-----------
F
T
E
G
-------------------------------------------------------
18
PsiBlast_PDB
54.73
23%
-73
- C2 -
1OID
1
USHA_ECOLI
A:
[14-502]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
C
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
K
V
T
-
W
E
D
G
K
--
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNKCGYVNTG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
13
PsiBlast_PDB
54.70
23%
-71
- C2 -
1HPU
3
USHA_ECOLI
A:
[14-502]
-------------
T
N
D
H
H
G
H
F
W
-----------------------------
R
-----
N
E
Y
G
E
Y
G
L
--------------------------------
A
A
Q
K
T
L
V
D
G
I
R
---
K
E
----
V
A
----
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
D
A
------------
E
P
D
F
R
--
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-----
T
G
E
R
L
F
K
---
P
W
A
L
--
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
-
D
D
T
A
K
I
-
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
-
L
Q
-
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
N
A
------
P
G
D
V
E
M
A
R
A
L
P
A
G
S
----
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMA
A
E
-------------------
N
--------------
K
-
K
--
Q
V
-------------------
D
Y
V
-
P
G
T
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
--
E
F
-
R
-
N
-
G
E
M
--
K
M
V
N
Y
Q
L
I
P
V
-----------------------------------------
N
L
----------
K
K
K
V
T
-
W
E
D
G
K
--
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
--
S
P
F
Q
N
-
K
G
K
A
Q
L
E
V
-
K
---
I
----------------------
G
E
T
N
G
R
L
--
E
----------
G
D
R
----
D
K
---
V
R
F
V
------
Q
-----
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
-
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
G
DIS
Y
K
N
V
L
K
V
Q
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
------
K
L
N
D
L
K
I
-----
K
----
G
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
LDNKPGYVNTG
F
I
D
A
E
-----
V
-
L
K
---------------------------------------------
11
PsiBlast_PDB
54.55
22%
-78
- C2 -
2Z1A
4
?
A:
[36-495]
--------------
N
D
T
H
A
H
L
E
P
--
V
E
L
-------------------
T
L
--
S
-----
G
E
K
T
P
V
G
G
--------------------------------
V
-
A
R
R
V
A
L
F
D
R
V
W
A
R
A
----
K
N
----
P
L
----
F
-
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
--------------
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
R
E
-----
P
-
R
L
K
G
L
---
F
A
P
Y
A
V
V
-----
V
-----
V
----
G
G
----
E
R
V
G
I
I
G
L
T
T
-
P
D
T
R
E
I
-
S
N
P
G
--
P
-
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
--
G
-
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
L
K
--------------------
L
A
R
R
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
---
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
--------------
G
-
K
--
D
V
-------------------
L
V
V
Q
A
W
E
-------------
W
G
K
V
V
G
L
L
E
V
T
F
D
AKG
E
L
-
L
-
A
-
Y
K
G
--
E
A
L
--
L
M
T
P
E
-----------
A
--
A
P
E
-----
D
F
F
A
K
-------
E
A
---
L
L
A
Y
----------
A
Q
P
V
M
A
L
M
Q
Q
V
--
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
R
R
E
S
--
N
-
L
G
N
L
I
T
D
G
M
L
W
K
-
T
---
R
----------------------
N
A
G
T
Q
I
A
--
L
----------
Q
N
G
GGIR
A
S
---
I
P
K
G
------
P
-----
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
-
K
G
K
E
I
L
A
A
L
E
N
G
----
V
S
Q
W
E
-------
N
T
A
G
R
F
L
----------------------
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
-
P
A
G
S
R
V
V
R
V
E
V
-----
K
----
T
E
K
GYVP
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
-----------
L
K
E
A
-------------------------------------------------------
43
Fugue
53.89
18%
-67
- C2 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
---H
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
L
E
P
--
H
E
T
-------------------
R
I
--
N
LNG
Q
Q
T
K
V
D
I
G
G
F
--------------------------------
S
A
V
N
A
K
L
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---
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K
----
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----
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----
L
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------------
G
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----
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Y
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---
K
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-------------------
P
--------------
N
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--
P
V
-------------------
F
V
M
E
G
W
A
-------------
Y
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---
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--
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P
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-----------
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K
W
A
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---
T
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----------
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--
K
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V
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---
A
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SANRIPNKAGSNPEGS
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A
--------------------------
F
P
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G
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K
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L
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V
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Q
----
W
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----
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N
K
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Y
L
V
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V
A
G
G
K
D
G
Y
K
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-----------
F
G
K
L
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---
Y
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F
N
A
ST--------