@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0143: (2016-03-12 )
MLTIPEKENRGSKEQEVAIMIDALADKGKKALEALSKKSQEEIDHIVHQMSLAAVDQHMVLAKLAHEETGRGIYEDKAIKNLYASEYIWNSIKDNKTVGIIGEDKEKGLTYVAEPIGVICGVTPTTNPTSTTIFKAMIAIKTGNPIIFAFHPSAQESSKRAAEVVLEAAMKAGAPKDIIQWIEVPSIEATKQLMNHKGIALVLATGGSGMVKSAYSTGKPALGVGPGNVPSYIEKTAHIKRAVNDIIGSKTFDNGMICASEQVVVIDKEIYKDVTNEFKAHQAYFVKKDELQRLENAIMNEQKTGIKPDIVGKSAVEIAELAGIPVPENTKLIIAEISGVGSDYPLSREKLSPVLALVKAQSTKQAFQICEDTLHFGGLGHTAVIHTEDETLQKDFGLRMKACRVLVNTPSAVGGIGDMYNELIPSLTLGCGSYGRNSISHNVSATDLLNIKTIAKRRNNTQIFKVPAQIYFEENAIMSLTTMDKIEKVMIVCDPGMVEFGYTKTVENVLRQRTEQPQIKIFSEVEPNPSTNTVYKGLEMMVDFQPDTIIALGGGSAMDAAKAMWMFFEHPETSFFGAKQKFLDIGKRTYKIGMPENATFICIPTTSGTGSEVTPFAVITDSETNVKYPLADFALTPDVAIIDPQFVMSVPKSVTADTGMDVLTHAMESYVSVMASDYTRGLSLQAIKLTFEYLKSSVEKGDKVSREKMHNASTLAGMAFANAFLGIAHSIAHKIGGEYGIPHGRANAILLPHIIRYNAKDPQKHALFPKYEFFRADTDYADIAKFLGLKGNTTEALVESLAKAVYELGQSVGIEMNLKSQGVSEEELNESIDRMAELAFEDQCTTANPKEALISEIKDIIQTSYDYKQ
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..--------------.....290......-.300.......310.......320.......330.......-340.......350.......360.......370.......380.......---390...----....400.......410.......420..-.....430........440.......450.......460.......470.......480..---.---.---...490.....-..500.......510.......520.......530.......540.......550.......560.......570.-......580.......590.....---..600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700..-.....710.......720.......730.......740.......750.......-760.......770.......780......--.790.--........800.......810.......820.......830.......840.......850.......860.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLTIPEKENRGSKE
Q
E
V
A
I
M
I
D
A
L
A
D
K
G
K
K
A
L
E
A
L
S
KK
S
Q
E
E
I
D
H
I
V
H
Q
M
S
L
A
A
V
D
Q
H
M
V
L
A
K
L
A
H
E
ETGRGIY
E
D
K
A
I
K
N
L
Y
A
S
E
Y
I
W
N
SIKDN
K
T
V
G
I
IGEDKEKG
L
T
Y
V
AE
P
I
G
V
I
CGVTPTTNP
T
S
T
T
I
F
K
A
M
I
A
I
KTG
N
P
I
I
F
A
FHPSA
Q
E
S
S
K
R
A
A
E
V
V
L
E
A
A
M
KAG
A
P
K
D
I
I
Q
W
IEVP
S
I
E
A
T
K
Q
L
MNHK
G
I
A
L
V
L
ATGGSG
M
V
K
SAYSTGKPALGVGPGN
V
P
S
Y
I
E
K
T
A
H
I
K
R
A
V
N
D
I
IGSKTFDN
G
M
I
CAS
E
Q
V
V
V
I
D
K
E
I
Y
K
D
V
T
N
E
F
KAH
Q
A
Y
--------------
F
V
K
K
D
E
L
Q
R
L
E
N
A
I
-MNEQKTGIKPDIVGK
S
A
V
E
I
A
E
L
AGIPVPEN
T
K
L
I
I
A
E
ISG-VGSDYPL
S
R
E
K
L
S
P
V
L
A
L
V
K
A
Q
S
T
K
Q
A
F
Q
I
C
E
D
T
L
HFGGLG
H
T
A
V
I
HTE
D
---
E
T
L
Q
K
D
----
F
G
L
R
M
K
A
C
R
V
LVNTPSAVG
G
I
G
D
M
Y
N
E
L
I
-
P
S
LTLGC-GSYGRNSISHNVSAT
D
L
L
N
I
K
T
I
A
KRRNN
T
Q
I
F
K
VP
A
Q
I
Y
FEEN
A
I
M
S
L
T
T
M
D
---
K
---
I
---
E
K
V
M
I
V
CDPG
M
-
V
EFG
Y
T
K
T
V
E
N
V
L
R
QRTEQP
Q
I
K
I
F
S
EVEPNPST
N
T
V
Y
K
G
L
E
M
M
V
DFQP
D
T
I
I
A
LGGG
S
A
M
D
A
A
K
A
M
W
M
F
F
EHPET-SFF
G
A
K
Q
K
F
L
D
IG
K
R
T
Y
KIGMPEN---
A
T
F
I
C
I
PTTSGTGSE
V
T
P
F
A
V
I
TDSETNVKYPLADFALTPD
V
A
I
I
D
P
Q
F
V
M
SV
P
K
SVTADT
G
M
D
V
L
T
H
A
M
E
S
Y
V
S
V
M
A
S
D
YTRG
L
S
L
Q
A
I
K
L
T
F
E
Y
L
K
S
S
V
EKGDK
V
-
S
R
E
K
MH
N
A
S
T
L
A
G
M
A
F
A
N
A
F
L
G
I
A
H
S
I
A
H
KIGGEYGIPHGRA
N
A
I
L
L
P
H
I
IRYNA-KDPQKHALFP
K
Y
E
F
F
RADT
D
Y
A
D
I
A
K
F
LG--LK--G--N
T
T
E
A
L
V
E
S
L
A
K
A
V
Y
E
L
G
Q
SV
G
I
E
M
N
LKSQGV
S
E
E
E
L
N
E
S
I
D
R
M
A
E
L
A
FEDQCTTAN
P
K
E
A
L
I
S
E
I
K
D
I
I
Q
TSYDYKQ
21
PsiBlast_CBE
92.67
48%
-79
- C1 -
3K9D
2
?
C:
[12-446]
--------------
Q
E
V
R
N
L
I
E
S
-
A
N
K
A
Q
K
E
L
A
A
M
S
---
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
--------------
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
-
L
R
P
N
G
S
-
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
R
E
----
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.24
48%
-78
- C1 -
3K9D
1
?
A:
[12-446]
--------------
Q
E
V
R
N
L
I
E
S
-
A
N
K
A
Q
K
E
L
A
A
M
S
---
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
--------------
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
-
L
R
P
N
G
S
-
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
R
E
----
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
92.21
45%
-75
- C1 -
3K9D
1
?
A:
[3-456]
---------
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
--------------
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
-
L
R
P
N
G
S
-
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
R
E
----
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.88
48%
-75
- C1 -
3K9D
1
?
B:
[12-446]
--------------
Q
E
V
R
N
L
I
E
S
-
A
N
K
A
Q
K
E
L
A
A
M
S
---
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
--------------
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
-
L
R
P
N
G
S
-
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
R
E
----
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.25
48%
-79
- C1 -
3MY7
1
?
A:
[9-449]
--------------------
L
D
A
M
I
A
R
V
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
H
--------------
V
L
S
K
T
D
A
D
K
V
R
K
V
L
-
L
I
D
G
A
L
N
A
K
--
I
V
G
Q
P
A
T
A
I
A
E
M
A
G
V
K
V
P
A
D
T
K
V
L
I
G
E
G
L
G
K
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
-
N
---
Q
D
V
N
A
D
R
I
R
Y
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
87.54
44%
-72
- C1 -
3K9D
1
?
A:
[3-452]
---------
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
--------------
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
--
S
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
R
E
----
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
P
A
L
T
L
G
C
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
81.44
47%
-60
- C1 -
3MY7
1
?
A:
[2-449]
-------------
P
V
T
N
M
A
E
L
D
A
M
I
A
R
V
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
H
V
L
S
K
T
D
A
D
K
V
R
K
V
L
L
I
D
G
A
L
N
A
K
I
V
G
Q
P
-
A
T
A
I
A
--
E
M
A
---
G
V
---
K
V
P
A
D
T
K
V
L
I
G
E
G
-------
L
G
K
-
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
N
Q
DVN
A
D
R
I
R
Y
----
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.58
34%
-79
- C2 -
3BFJ
1
DHAT_KLEPN
E:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
39
PsiBlast_CBE
80.57
34%
-79
- C2 -
3BFJ
1
DHAT_KLEPN
F:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
41
PsiBlast_CBE
80.54
34%
-78
- C2 -
3BFJ
1
DHAT_KLEPN
D:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
5
PsiBlast_PDB
80.16
34%
-79
- C2 -
3BFJ
1
DHAT_KLEPN
A:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
25
PsiBlast_CBE
80.13
34%
-77
- C2 -
3BFJ
14
DHAT_KLEPN
T:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
43
PsiBlast_CBE
79.63
34%
-76
- C2 -
3BFJ
1
DHAT_KLEPN
B:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
42
PsiBlast_CBE
79.54
34%
-77
- C2 -
3BFJ
1
DHAT_KLEPN
C:
[8-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
---
Q
---
L
LGG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
--
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
-
L
Y
Q
Y
A
-------
G
I
E
T
L
T
N
P
L
P
P
------
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
---------------
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
----
64
HHSearch
78.79
35%
-70
- C2 -
1RRM
4
FUCO_ECOLI
A:
[4-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
---
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
--
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
------
S
---
P
T
N
K
P
S
---
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
-
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
--------------
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
--
V
EG
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
G
--
23
PsiBlast_CBE
76.72
34%
-78
- C2 -
2BL4
2
FUCO_ECOLI
B:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
T
D
E
V
---
K
RRG
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
--
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
--
R
S
L
E
G
L
S
P
T
N
KPS
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
D
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
-------------
F
T
G
E
K
-
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
----
3
PsiBlast_PDB
76.67
34%
-82
- C2 -
2BI4
3
FUCO_ECOLI
A:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
T
D
E
V
---
K
R
R
G
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
--
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
--
R
S
L
E
G
L
S
P
T
N
KPS
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
D
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
-------------
F
T
G
E
K
-
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
----
24
PsiBlast_CBE
76.66
34%
-79
- C2 -
2BI4
2
FUCO_ECOLI
B:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
T
D
E
V
---
K
RRG
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
--
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
--
R
S
L
E
G
L
S
P
T
N
KPS
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
D
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
-------------
F
T
G
E
K
-
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
----
8
PsiBlast_PDB
76.32
34%
-74
- C2 -
1RRM
4
FUCO_ECOLI
A:
[13-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
T
D
E
V
---
K
R
R
G
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
--
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
--
R
S
L
E
G
L
S
P
T
N
KPS
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
D
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
-------------
F
T
G
E
K
-
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
---
4
PsiBlast_PDB
75.39
34%
-80
- C2 -
2BL4
3
FUCO_ECOLI
A:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
T
D
E
V
---
K
R
R
G
Y
---
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
--
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
--
R
S
L
E
G
L
S
P
T
N
KPS
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
D
K
D
-
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-
D
-------------
F
T
G
E
K
-
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
----
10
PsiBlast_PDB
48.04
34%
-53
- C2 -
1O2D
2
?
A:
[73-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
K
D
L
-
S
V
----
E
D
L
Y
D
--
R
E
K
V
K
H
W
L
P
-------
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
N
K
R
G
C
T
L
M
F
---
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
-
G
N
R
E
-
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
--------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.59
34%
-53
- C2 -
1VHD
3
?
A:
[63-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
K
D
L
-
S
V
----
E
D
L
Y
D
--
R
E
K
V
K
H
W
L
P
-------
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
N
K
R
G
C
T
L
M
F
---
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
-
G
N
R
E
-
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
--------------------------------------------------------------------------------------------------------------------------