@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0148: (2016-03-12 )
MFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDVRDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICLSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFIDKIKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEKITQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELNDYKASMR
Atome Classification :
(20 SA)
--.........10........20......-.-.30........40........50-----.........60....--....70...--.....80........90..---......100.......-110.-----.----.....120.......130.......140.......150.......160.......170.......180--..-.-....190.......200.......210.......220--.....--..230.......240--..-.----------------------....250-.......260-----........270.......280.-----...----..-..290.......300.......310-.......320....--...330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MFDD
K
I
L
L
I
TGGTG
S
F
G
N
A
V
M
K
R
F
L
DS-N-I
K
E
I
R
I
FSRDE
K
K
Q
D
D
I
R
K
KYN------NS
K
L
K
F
Y
I
GDVRD
S
Q
--
S
V
E
T
A
M
R
D
V
--
D
Y
V
F
H
A
A
A
L
K
QVPSC
E
F
F
P
---
V
E
A
V
K
T
NIIG
T
E
N
V
L
Q
-
S
A
I
H
-----
Q
----
N
V
K
K
V
I
C
LSTDKAAYP
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
AKSRNIRSE
Q
T
L
I
C
GTRYGNVMASRG
S
V
I
P
L
F
I
D
KI--KA-G-E
P
L
TIT
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
KHAETG
D
I
M
--
V
QKAP--SS
T
V
G
D
L
A
T
A
L
L
E
L
F--EA-D----------------------N
A
I
E
I
I
G-TRHG
E
K
K
A
E
------
T
L
L
T
R
E
E
Y
A
Q
C
E
DMG
D
Y
F
RV-P-----ADS----RD-LNY
S
N
YVETGNE
K
I
T
Q
S
Y
EYNSDN
T
-
H
I
L
T
V
E
E
I
K
E
K
L
L
T
--
L
E
Y
V
R
N
E
L
N
D
Y
KASMR
1
PsiBlast_PDB
92.64
100%
-93
- C1 -
3W1V
11
?
A:
[23-359]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
-
N
-
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
------
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
---
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
-
S
A
I
H
-----
Q
----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
--
K
A
-
G
-
E
P
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
--
V
Q
K
A
P
--
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
--
E
A
-
D
----------------------
N
A
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
------
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
-
P
-----
A
D
S
----
R
D
-
L
N
Y
S
N
Y
V
E
T
G
N
E
K
I
T
Q
S
Y
E
Y
N
S
D
N
T
-
H
I
L
T
V
E
E
I
K
E
K
L
L
T
--
L
E
Y
V
R
N
E
L
N
D
Y
K
----
21
PsiBlast_CBE
92.35
100%
-93
- C1 -
3W1V
10
?
B:
[23-358]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
-
N
-
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
------
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
---
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
-
S
A
I
H
-----
Q
----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
--
K
A
-
G
-
E
P
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
--
V
Q
K
A
P
--
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
--
E
A
-
D
----------------------
N
A
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
------
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
-
P
-----
A
D
S
----
R
D
-
L
N
Y
S
N
Y
V
E
T
G
N
E
K
I
T
Q
S
Y
E
Y
N
S
D
N
T
-
H
I
L
T
V
E
E
I
K
E
K
L
L
T
--
L
E
Y
V
R
N
E
L
N
D
Y
-----
2
PsiBlast_PDB
92.29
100%
-96
- C1 -
4G5H
18
?
A:
[23-358]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
-
N
-
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
------
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
---
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
-
S
A
I
H
-----
Q
----
N
V
K
K
V
I
C
L
S
T
D
K
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
--
K
A
-
G
-
E
P
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
--
V
Q
K
A
P
--
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
--
E
A
-
D
----------------------
N
A
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
------
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
-
P
-----
A
D
S
----
R
D
-
L
N
Y
S
N
Y
V
E
T
G
N
E
K
I
T
Q
S
Y
E
Y
N
S
D
N
T
-
H
I
L
T
V
E
E
I
K
E
K
L
L
T
--
L
E
Y
V
R
N
E
L
N
D
Y
-----
3
PsiBlast_PDB
89.39
99%
-97
- C1 -
3VVC
6
?
A:
[23-358]
---
F
D
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
-
N
-
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
------
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
--
D
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
---
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
-
S
A
I
H
-----
Q
----
N
V
K
K
V
I
C
L
S
T
D
E
A
A
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
I
D
K
I
--
K
A
-
G
-
E
P
L
T
I
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
E
T
G
D
I
M
--
V
Q
K
A
P
--
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
--
E
A
-
D
----------------------
N
A
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
------
T
L
L
T
R
E
E
Y
A
Q
C
E
D
M
G
D
Y
F
R
V
-
P
-----
A
D
-------------------------
Y
E
Y
N
S
D
N
T
-
H
I
L
T
V
E
E
I
K
E
K
L
L
T
--
L
E
Y
V
R
N
E
L
N
D
Y
-----
4
PsiBlast_PDB
82.82
67%
-95
- C1 -
4J2O
2
?
A:
[21-351]
---
F
K
D
K
V
L
L
I
T
G
G
T
G
S
F
G
N
A
V
L
K
R
F
L
E
T
-
D
-
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
M
R
K
K
Y
H
------
S
A
K
L
K
F
Y
I
G
D
V
R
D
Y
N
--
S
I
L
N
A
T
R
G
V
--
D
Y
I
Y
H
A
A
A
L
K
Q
V
P
S
C
E
F
H
P
---
M
E
A
V
K
T
N
V
L
G
T
E
N
V
L
E
-
A
A
I
Q
-----
N
----
H
V
K
R
V
V
C
L
S
T
D
K
A
V
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
M
V
A
K
S
R
N
L
E
G
L
D
T
V
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
V
I
P
L
F
V
D
Q
I
--
R
Q
-
G
-
K
P
L
T
I
T
D
P
N
M
T
R
F
M
M
T
L
E
D
A
V
D
L
V
L
Y
A
F
E
H
G
E
N
G
D
I
F
--
V
Q
K
A
P
--
A
A
T
I
A
V
L
A
E
A
L
K
Q
L
L
--
N
V
E
D
----------------------
H
P
I
S
I
M
G
-
T
R
H
G
E
K
A
F
E
------
A
L
L
S
R
E
E
M
V
H
A
F
D
Q
G
D
Y
F
R
V
-
P
-----
A
D
Q
-------------------------
D
Y
N
S
H
N
T
-
T
R
L
D
V
E
G
M
K
Q
L
L
L
K
--
L
D
F
V
R
-----------
7
PsiBlast_PDB
68.06
40%
-68
- C1 -
2GN8
3
PSEB_HELPY
A:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQ
T
P
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
24
PsiBlast_CBE
68.05
40%
-71
- C1 -
2GN8
3
PSEB_HELPY
B:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQTP
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
37
Fugue
68.04
40%
-70
- C1 -
2GN4
3
PSEB_HELPY
A:
[16-344]
QN
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
--
Q
N
K
A
-
S
E
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
A
P
-------
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
-
Q
PTISF
Q
T
P
----
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
Q
W
L
E
P
D
D
L
L
K
L
L
-------------------
5
PsiBlast_PDB
67.83
40%
-72
- C1 -
2GN4
3
PSEB_HELPY
A:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQ
T
P
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
22
PsiBlast_CBE
67.59
40%
-72
- C1 -
2GNA
3
PSEB_HELPY
B:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQTP
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
23
PsiBlast_CBE
67.55
40%
-73
- C1 -
2GN9
4
PSEB_HELPY
B:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQ
T
P
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
9
PsiBlast_PDB
67.27
40%
-71
- C1 -
2GNA
2
PSEB_HELPY
A:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
QN
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQTP
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
6
PsiBlast_PDB
67.17
40%
-70
- C1 -
2GN6
2
PSEB_HELPY
A:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQTP
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
26
PsiBlast_CBE
66.48
40%
-69
- C1 -
2GN4
4
PSEB_HELPY
B:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQ
T
P
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
8
PsiBlast_PDB
66.40
40%
-70
- C1 -
2GN9
2
PSEB_HELPY
A:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQTP
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
25
PsiBlast_CBE
66.20
40%
-65
- C1 -
2GN6
3
PSEB_HELPY
B:
[18-332]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
-
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
Q
N
K
A
-
S
-
E
-
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
------
A
P
-
N
----------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
------
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
-----
T
I
S
FQ
T
P
K
D
-
Y
T
L
T
K
L
H
E
K
G
-
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
-
N
-------------------------------
38
Fugue
63.88
35%
-76
- C1 -
4TQG
1
?
A:
[1-319]
-S
Q
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
N
-
N
---
I
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
------
S
D
K
L
K
N
I
I
G
D
I
R
D
F
E
--
K
V
Q
Q
S
I
M
R
I
NP
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
---
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
-
V
T
E
I
NRSNL
S
----
N
L
K
A
V
C
F
V
S
T
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
K
D
--
I
K
Y
V
C
V
R
Y
G
N
V
L
----------------------
N
F
T
L
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
--
I
P
K
L
N
--
S
M
Y
I
K
D
M
I
E
L
F
A
D
K
Y
--
P
---------------------------
I
V
I
T
G
-
L
R
S
G
E
R
M
Y
E
------
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
-
L
-----
P
T
Y
----
D
P
-
T
I
V
T
E
----------
E
F
Y
E
Y
S
S
K
Q
--
N
I
L
S
K
Q
E
L
E
N
Y
L
N
Q
------------------
48
HHSearch
63.62
38%
-61
- C1 -
2GN4
3
PSEB_HELPY
A:
[18-344]
--
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
--
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
---
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
-
A
C
L
K
-----
N
----
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N
N
F
K
G
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
V
V
P
F
F
K
K
L
V
--
Q
N
-
K
A
S
E
I
P
I
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
H
G
G
E
I
F
--
V
P
K
I
P
--
S
M
K
M
T
D
L
A
K
A
L
A
P
N
T
--
P
T
-
K
----------------------
I
I
----
G
-
I
R
P
G
E
K
L
H
E
VMIPKD
E
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
T
I
S
F
-
Q
-----
T
P
K
----
D
Y
-
T
-
L
T
K
L
H
E
K
-
G
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
N
Q
W
L
E
P
D
D
L
L
K
L
L
--------------------
10
PsiBlast_PDB
63.22
37%
-93
- C1 -
4TQG
1
?
A:
[3-285]
---
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
N
-
N
-
I
--
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
------
S
D
K
L
K
N
I
I
G
D
I
R
D
F
E
--
K
V
Q
Q
S
I
M
R
I
NP
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
---
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
N
-----
R
SNLS
N
L
K
A
V
C
F
V
S
T
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
K
-
D
I
K
Y
V
C
-
V
R
Y
G
N
V
L
N
----------------------
F
T
L
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
--
I
P
K
L
N
--
S
M
Y
I
K
D
----
M
I
E
L
F
A
D
K
Y
-------------------------
P
I
V
I
T
G
-
L
R
S
G
E
R
M
Y
E
------
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
---------------------------------------------------------------------------
47
HHSearch
59.54
25%
-84
- C1 -
3PVZ
7
?
A:
[32-386]
--
V
V
S
Q
S
R
F
L
V
L
G
G
A
G
S
I
G
Q
A
V
T
K
E
I
F
K
R
-
N
-
P
Q
K
L
H
V
V
D
I
S
E
N
N
M
V
E
L
V
R
D
I
R
S
S
FGYI
N
G
D
F
Q
T
F
A
L
D
I
G
S
I
E
Y
D
A
F
I
K
A
D
G
Q
Y
--
D
Y
V
L
N
L
S
A
L
K
H
V
R
-
S
E
K
D
P
F
T
L
M
R
M
I
D
V
N
V
F
N
T
D
K
T
I
Q
-
Q
S
I
D
-----
A
----
G
A
K
K
Y
F
C
V
S
T
D
K
A
A
N
P
V
N
M
M
G
A
S
K
R
I
M
E
M
F
L
M
R
K
S
-----
E
E
I
A
I
S
T
A
R
F
A
N
V
A
F
S
D
G
S
L
L
H
G
F
N
Q
R
I
--
Q
K
-
N
-
Q
P
I
-
V
A
P
N
D
I
K
R
Y
F
V
T
P
Q
E
S
G
E
L
C
L
M
S
C
I
F
G
E
N
R
D
I
F
F
P
K
L
S
E
A
L
H
L
I
S
F
A
D
I
A
V
K
Y
L
K
Q
L
--
G
Y
-
E
P
H
L
C
ES
E
D
E
A
R
E
L
A
K
TLPAQG
K
W
P
C
L
F
T
S
S---------------
E
F
F
T
D
K
E
T
L
D
M
A
R
F
D
N
L
G
I
I
-
K
-----
N
D
S
----
L
Y
Q
Q
E
L
L
E
L
F
E
Q
--------
K
I
G
Q
M
K
T
D
-
R
Q
W
T
K
E
E
I
V
Q
L
F
F
I
M
I
P
D
F
-------------