@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0173: (2016-03-12 )
MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFFDVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFADAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIALDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQQHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSLSLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIETLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQQVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAMIGVLKAGGAYVPIDPNYPSDRQEYILKDATPKVVITYQALYENGKQNINHIDLNKIAWKNIDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHRNHYVPLNEETTILLSGTIAFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERIEVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIPIGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMYRSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQYIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVDTDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQIGDLLQKPTVFELAQAIAKVQEQNYEVIPEAIVKDDYVLSSAQKRMYLLWKSNHKDTVYNVPFLWRLSSGLNVAQLQQAVQHLIARHEILRTQYIVVDDEVRQRIVADVVADFEEVNTHFTDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALYQHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAMMSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTEQMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRNPLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLYHSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSIISYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEMIAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGFVESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTELQLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVASIPLQMCSIMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCGDLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNNPFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENVILAIRGISDCVVTVSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRLPNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHLKRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLSHRPLGNTLLTGATGFLGAYLIEALQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETVEMMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLAQQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNNGLDGRIVRVGNLTSPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTTARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETIGLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70....----....80........90........100........110.......120..-.....130.......140.......150.......160.......170.......180.......190.......200.......210----...-------...--...220.....---..230.......240.......250...---.-----...260.......270.......280.......290---........300.......310..-.....320.-----.---...--....330.......340...--.....350.......360.......370.......380.......390........400.......410.......420.......430.-......440.......450.......460.......470.......480.......490.......500.......510...--.---...520....-..---.--530--.-..--...--.540.......550.......560------------------.......570.....---..580.-.--..-...590.......600.......610.......620.......630.......640.......650---.........---660---.......670.......----680--.-......690.--......700.---......710..---.--..--..--.720.--......--730.--..-.--..--.740.......750.......760.......--770.-.-.-.--...--780.......790.......800.......810.......820.......830.....-.-.840.......850.------....---....860.......870.......880.......890.......900........910....-...920.......930.......940.......950-..-.....960.......970.......980.......990.......1000......1010......1020......1030......1040......1050.....-.1060......1070---.....-..1080-----....--....-------.1090......1100......-1110.-...-..1120......1130...----...1140-.-----.....1150......1160--.----...----....1170-........1180......1190.....---.1200......1210......1220......1230......1240......1250...--...1260......1270......1280......1290......1300......1310......1320......1330-----........-----1340....--..--1350--......1360......1370......1380......1390......1400......1410......1420......1430...----...1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550........-1560........1570......1580...-...1590......1600......1610......-1620......1630......1640......1650......1660......1670.....-.1680-.......----1690----..--...--------...1700......-1710.--..--...1720......1730.......1740..--....1750......1760.-..-....1770......1780......1790......1800-..-.-...1810......1820......1830......1840......1850.....-.1860......--.-1870..-..-..1880.------......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980.......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIMG
N
L
R
F
Q
Q
E
Y
F
R
I
Y
KNNTESTTHR
N
A
Y
W
V
K
LAKN
V
E
A
T
K
M
M
Y
A
L
S
T
I
V
Q
Q
H
A
S
I
R
H
F
F
DVTTDD
N
L
T
M
I
L
H
E
F----L
P
F
I
E
I
KQVPSSSAN
Y
D
L
E
A
F
F
K
Q
E
-
L
S
TYHFNDS
P
L
F
K
V
K
L
F
QFA
D
A
A
Y
-
I
L
L
D
F
H
V
S
IFDDS
Q
I
D
I
F
L
D
D
L
C
N
A
YRGNTVINNTRQ
H
A
HINRNDDKDNQDA
S
H
I
A
LDS
N
Y
F
R
LENNS
D
I
H
IDSYFPIK
H
P
F
E
Q
A
L
------
Y
Q
T
-------
Y
L
I--DDMTS
I
D
M
A
S
L
---
A
V
S
V
Y
L
A
N
H
I
M
SQQH
D
V
T
L
G
I
HVPSHLP---N-----DLHG
N
I
V
P
L
T
L
T
I
D
A
K
D
V
C
Q
R
F
T
T
D
F
N
K
C
V
L
Q
N
M
S
----
Q
L
Q
C
A
K
SSL
S
L
E
T
I
F
H
C
Y
H
H
M
M
S
-
C
C
N
D
V
I
--
E
-----
D
---
V
H
Q
--
I
H
D
AHTSL
A
D
I
E
I
F
PH-QHG--
F
K
I
I
YNSAA
Y
D
L
L
S
I
E
T
L
S
D
L
V
R
N
I
Y
L
Q
I
TEENGNKRT
T
V
D
E
L
NLMT-ERD
I
Q
L
Y
DDINLSLPEIDD
A
Q
T
V
V
T
L
F
E
Q
Q
V
EATP
N
H
V
A
V
Q
F-D
G
V
F
I
T
Y
Q
T
L
N
A
R
A
N
D
L
A
H
R
L
R
N
QYGVEPND
R
V
A
V
I
A
E
K
S
I
E
M
I
I
A
M
I
G
V
LKAG
G
A
Y
V
PIDPNYP
S
D
R
Q
E
Y
I
LKDATP
K
V
V
I
--
T
---
Y
Q
A
L
Y
ENGKQ-NI---N--HID--
L
-
N
K
--
I
A
W
--KNID
N
L
SKCNTLED
H
A
Y
V
I
Y
TSGT------------------TGNPK
G
T
LIP
H
R
G
I
V
---
R
L
V
HRN-H--YV-PLNEE
T
T
I
L
L
S
G
T
I
A
FD
A
A
T
F
E
I
Y
G
A
L
LNG
G
K
L
I
V
A
K
K
E
QLL
N
P
I
A
V
E
Q
L
INENDV
N
T
M
W
L
T
S
S
-----
L
F
N
Q
I
A
S
E
R
---
I
E
V
---
L
V
P
L
K
Y
L
L
IGGEVL
N
A
K
----
W
V
D
--
L
-
L
NQKPKHP
Q
I
--
I
NGYGPTE
N
T
---
T
F
T
T
TYNI-PN---K--VP--NR--IPIGK--PIL
G
T
H
--
V
Y
I
M
--QG-E--RR--CGVGI
P
G
E
L
C
TSG
F
G
L
A
AGYLNQPEL
T
A
D
KF--IKDS-N-I-
N
--
Q
L
M--YRSG
D
I
V
R
LLPDGN
I
D
Y
L
Y
RKD
K
Q
V
K
I
R
G
F
R
I
E
L
S
E
V
E
H
A
L
E
R
I
QGI
N
K
A
V
V
I
V
QNHD-Q-D
Q
Y
I
V
A
Y
Y
E
A
M
H
--
T
------
L
S
H
N
---
K
I
K
S
Q
L
R
MTLPE
Y
M
I
P
V
N
F
M
H
I
E
Q
I
P
I
T
INGKLDKKALP
I
M
D
YVD-TDAYVAPST
D
T
E
H
L
L
C
-
Q
I
F
A
D
I
L
H
V
NQVGIHD
N
F
F
E
LGGH
S
L
K
A
T
L
V
V
N
R
I
E-AS-TG
K
R
L
Q
I
G
D
L
LQKP
T
V
F
E
L
A
Q
A
I
A
K
V
Q
EQNYEV
I
P
E
A
IVKD
D
Y
V
L
S
S
A
Q
K
R
M
Y
L
L
W
KSNHKD
T
V
YNV
P
F
L
W
RLSSGL
N
V
A
Q
L
Q
Q
A
V
Q
H
L
I
A
R
H
E
I
L
R
T
Q
Y
I
V
V
D
-
D
E
V
R
Q
R
I
V
A
D
V
V
A
D
----
F
E
E
V
N-THF--------T
D
E
Q
--
E
I
M
R
-------
Q
F
VAPFNLEKP
S
Q
I
R
V
R
Y
I
RS-P
L
H
A
Y
-
L
F
I
-D
T
H
H
I
I
NDGMS
N
I
Q
L
M
N
D
L
----
N
A
L
Y
Q
HK-L-----L
L
P
L
K
L
QYK
D
Y
S
E
W
M
S
H----R----
D
M
T
----
K
H
R
Q
Y
W
---
L
S
Q
F
KDEV
P
I
LSL
P
T
D
Y
VRPNIKTTNG---
A
M
M
S
F
T
M
N
Q
Q
M
R
Q
L
L
Q
K
Y
V
E
K
HQ
I
T
D
F
M
F
F
M
S
V
V
M
T
L
L
S
R
YARKDDV
V
V
G
S
V
M
S
A
R
MH--K
G
T
E
Q
M
L
G
M
F
A
N
T
L
V
YRGQP
S
P
D
K
M
W
T
Q
F
L
Q
E
V
K
E
M
S
L
E
A
Y
EHQEY
P
F
E
C
L
V
N
D
L
D
QSHDASRNP
L
F
D
V
M
L
V
L
QN-------NETNHAHF-----GHSK
L
T
H
I--QP--KS
V
T
--
A
K
F
D
L
S
F
I
I
EEDRD
D
Y
T
I
N
I
E
YNTDLY
H
S
E
T
V
R
H
MGN
Q
C
M
I
M
I
D
Y
I
LKHQD
T
L
Q
I
CDIPN
G
T
E
E
L
L
N
W
V
N
T
HVND
R
M
LNVPGN----
K
S
I
I
S
Y
F
N
E
V
V
SRQG
N
H
V
A
L
V
M
N
D
L
T
M
T
Y
E
T
L
R
N
Y
V
D
A
I
A
H
M
L
L
SNGVGNG
Q
R
V
A
L
F
T
E
R
S
F
E
M
I
A
A
M
L
A
T
V
KVG
A
S
Y
I
P
I
DIDFPNKRQG
A
I
LED
A
K
V
T
A
V
M
SYG
V
E
I
E
T
T
L
P
V
--
I
Q
LENAKG-FV--ESKENEQYDDLHGNQLEN
T
A
MLDN
E
-
M
Y
A
I
Y
TSGTTGMPKGV
A
I
R
Q
R
N
L
L
N
L
V
H
A
WS
T
E
-
L
QLGD
N
E
V
F
L
Q
HA
N
I
V
F
D
A
S
V
M
E
I
Y
C
C
L
LNG
H
T
L
V
IP
D
R
E
ERV
N
P
E
Q
L
Q
Q
L
I
N
KHR
V
T
V
-
A
S
I
P
--
L
Q
M
C
S
I
M
----
E
D
------
F
Y
--
I
E
K
--------
L
ITGGAT
S
T
A
S
F
V
-
K
Y
I
E
K
--
H
C
--
G
T
Y
F
NAYGPSE
S
T
V
I
-
T
S
Y
W
S
H
H
C
GDLIPE--TIPIGKPLS
N
I
Q
V
Y
I
MS-D-
G
L
-
L
CGIGMPG
E
L
C
IAGD
S
L
A
I
G
YIN
R
P
E
L
M
A
D
K
WQNNPFG-KG-
K
-
L
Y
HSGDLARYTSDG
Q
I
E
F
LGRID
K
Q
V
K
VN
G
Y
R
I
E
L
D
E
I
E
N
V
I
L
A
IRGIS
D
C
V
-
V
T
V
S-HF
D
T
H
D
--
I
-
L
N
A
Y
YV-
G
E
-
Q
Q
V
E
-
Q
D
------
L
K
Q
Y
L
N
DQL
P
K
Y
MIPKTIT
H
I
D
C
M
PLTTNDKVDTTRLPNPSPIQQSNKVYSEP
S
N
E
I
E
Q
T
F
V
D
V
F
G
E
V
L
K
QNDVGVD
D
D
F
F
E
LGG
N
S
L
E
A
M
L
V
V
S
H
L
K
R
-FGH
H
I
S
M
Q
T
L
Y
Q
Y
K
T
V
R
Q
I
V
N
Y
M
Y
QNQ
Q
S
LVALPD
N
L
S
E
L
Q
K
I
V
M
S
RYNLGILEDSLSHRPLGN
T
L
L
TG
A
T
G
F
L
G
A
Y
L
I
E
A
L
QGYS
H
R
I
Y
C
F
I
R
ADNE
E
I
A
W
Y
K
L
M
T
N
L
N
D
Y
F
S
E
E
T
V
E
M
M
L
SNI
E
V
I
VGDFECMDDVVLPEN
M
D
T
I
I
HAGARTDHFGDDDE
F
E
K
VNVQG
T
V
D
V
I
R
L
A
Q
Q
HH
A
R
L
I
Y
V
S
T
ISV
G
T
Y
F
D
IDTEDVTFSEADVYK
G
Q
L
LTSPY
T
R
S
K
F
Y
S
E
L
K
V
L
E
A
V
NNGLD
G
R
I
V
R
VGNLTSPYNG
R
W
H
M
RNIK
T
N
R
F
S
M
V
M
N
D
L
L
Q
LDCIGV
S
M
A
EMPV
D
F
S
F
V
D
T
T
A
R
Q
I
V
A
L
A
QVNTP
Q
I
I
Y
H
VLSPNKM
P
V
K
S
L
L
E
C
V
K
RKE
I
E
LVSD
E
S
F
N
E
I
L
Q
K
Q
D
M
Y
E
TIGLTSVD
R
E
Q
Q
L
A
M
ID
T
T
L
T
L
K
I
M
N
H
I
S
E
KWPTI
T
N
N
W
L
Y
H
W
A
Q
Y
I
K
T
I
FNK
2
PsiBlast_PDB
91.84
29%
-80
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[9-1056]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
----
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
H
L
--------
T
G
S
E
--
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
-
A
E
E
S
F
-
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
-----
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
----
Q
----
D
K
Q
----
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
-------
T
T
F
A
E
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
P
K
------
L
I
D
H
I
I
V
F
E
N
YPLQDAK
N
E
E
S
S
E
N
G
-----
F
D
M
V
D
V
H
V
--
F
E
--
K
S
-----
N
Y
D
L
N
-
L
M
A
S
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
------
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
-
E
M
K
E
Q
A
A
E
--
L
P
Y
T
G
T
T
L
-
F
I
DD
Q
T
R
F
E
E
Q
A
S
D
------
P
A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
D
Y
--
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
-
M
F
A
T
--
T
A
L
F
N
L
L
T
D
A
G
E
D
------
W
M
KG
L
R
C
--------
I
L
F
G
G
E
R
A
S
V
P
H
V
-
R
K
A
L
R
I
M
G
P
--
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
P
D
S
I
-
S
--
S
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
-
E
Q
S
Q
-
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
-
P
G
-
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
-
V
V
A
D
-
R
H
E
S
G
D
--
A
S
I
N
A
Y
L
V
-
N
R
-
T
Q
L
S
A
E
D
------
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
A
E
E
-
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
90.20
28%
-77
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[7-1060]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
----
I
E
E
I
D
-
L
T
H
LT
G
S
E
Q
T
A
K
I
N
E
--
Y
K
E
Q
-------
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
-
W
V
W
-
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
----
F
K
V
Y
N
A
L
-
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
----
Q
----
D
K
Q
----
A
S
L
R
Y
W
---
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
---
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
------
Q
P
K
L
I
D
H
I
I
V
F
E
N
-------
Y
P
L
Q
D
A
K
N
EESSE
N
G
F
D
M
V
D
V
--
H
---
V
F
E
K
--
S
N
Y
D
L
N
L
M
A
S
-
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
-
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
-
A
H
E
T
----
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
E
Q
A
A
E
L
--
P
Y
T
G
T
T
L
F
-
I
D
--
D
---
Q
T
R
F
E
E
Q
-
A
S
D
P
A
T
A
I
D
P
N
D
P
-
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
-
D
Y
-
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
-
M
F
A
T
--
T
A
L
F
N
L
L
----
T
D
A
GEDWM
K
G
--
L
R
C
--------
I
L
F
G
G
E
R
A
S
V
P
H
V
-
R
K
A
L
R
--
I
M
GP
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
-
A
T
A
H
V
V
H
D
L
P
D
S
I
S
--
S
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
-
S
Q
-
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
P
G
E
-
T
-
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
-
V
V
A
D
R
H
E
S
G
D
A
--
S
-
I
N
A
Y
L
V
-
N
R
T
Q
L
S
A
-
E
D
------
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
-
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.64
100%
-90
- C1 -
4F6L
-
?
B:
[2013-2390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
P
D
N
L
S
E
L
Q
K
I
V
M
S
R
Y
N
L
G
I
L
E
D
S
L
S
H
R
P
L
G
N
T
L
L
T
G
A
T
G
F
L
G
A
Y
L
I
E
A
L
Q
G
Y
S
H
R
I
Y
C
F
I
R
A
D
N
E
E
I
A
W
Y
K
L
M
T
N
L
N
D
Y
F
S
E
E
T
V
E
M
M
L
S
N
I
E
V
I
V
G
D
F
E
C
M
D
D
V
V
L
P
E
N
M
D
T
I
I
H
A
G
A
R
--------
E
F
E
K
V
N
V
Q
G
T
V
D
V
I
R
L
A
Q
Q
H
H
A
R
L
I
Y
V
S
T
I
S
V
G
T
Y
F
D
I
D
T
E
D
V
T
F
S
E
A
D
V
Y
K
G
Q
L
L
T
S
P
Y
T
R
S
K
F
Y
S
E
L
K
V
L
E
A
V
N
N
G
L
D
G
R
I
V
R
V
G
N
L
T
S
P
Y
N
G
R
W
H
M
R
N
I
K
T
N
R
F
S
M
V
M
N
D
L
L
Q
L
D
C
I
G
V
S
M
A
E
M
P
V
D
F
S
F
V
D
T
T
A
R
Q
I
V
A
L
A
Q
V
N
T
P
Q
I
I
Y
H
V
L
S
P
N
K
M
P
V
K
S
L
L
E
C
V
K
R
K
E
I
E
L
V
S
D
E
S
F
N
E
I
L
Q
K
Q
D
M
Y
E
T
I
G
L
T
S
V
D
R
E
Q
Q
L
A
M
I
D
T
T
L
T
L
K
I
M
N
H
I
S
E
K
W
P
T
I
T
N
N
W
L
Y
H
W
A
Q
Y
I
K
T
I
F
N
-
28
HHSearch
74.78
26%
-80
* C2 *
2VSQ
2
SRFAC_BACSU
A:
[12-1060]
-
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
-
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
--
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EIK
G
VEHMV
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
HQYV
P
L
Y
D
I
Q
S
Q
A
D
Q
P
K
L
I
D
----
H
I
I
V
F
E
N
Y
P
L
QD
A
KNEES
S
ENG
F
D
M
V
D
V
H
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
---
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
A
-
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
-
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
--
T
---
H
Q
E
M
K
E
Q
A
A
E
-
L
P
YT
G
T
--
T
L
F
--
I
-
D
D
--
Q
T
R
FE
E
Q
A
S
D
P
A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
------------------
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
---
G
L
V
K
H
V
-
D
--
Y
M
-
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
-----
L
F
N
L
L
T
D
A
G
---
E
D
W
---
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
----
H
V
R
--
K
-
A
L
R
I
M
G
P
G
K
L
--
I
N
C
Y
G
P
T
E
G
T
---
V
F
A
T
A
H
V
V
-
H
D
LP-
D
--
S
I
--
S
S
--
L
P
I
G
K
--
P
I
S
N
A
S
--
V
Y
I
L
--
N
E
Q
S
--
Q
L
--
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
--
I
E
N
P
-
F
K
P
-
G
--
E
T
L
--
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
-
D
A
S
I
N
A
Y
L
V
N
R
T
--
Q
------
L
S
A
E
---
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
-
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
-
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
66.35
36%
-78
- C2 -
1AMU
4
GRSA_ANEMI
B:
[17-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
E
E
E
Q
Y
L
F
A
-
V
N
N
T
K
A
E
Y
P
R
D
----
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
----
K
H
L
V
H
L
--
I
H
N
-
Q
F
N
G
-
Q
V
--
E
I
F
E
E
D
T
I
K
I
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
-
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
-
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
-
I
T
L
P
--
P
T
Y
V
V
H
L
----
D
P
ERI---
L
S
--
I
Q
T
--------
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
------
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
-
A
T
T
W
V
-
A
T
K
E
T
I
G
H
--
S
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
D
-
E
-
N
L
Q
L
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
E
K
-
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
-
V
S
V
--
H
K
D
H
Q
E
Q
P
Y
-
L
C
A
Y
F
V
-
S
E
-
K
H
I
P
L
E
Q
------
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.32
36%
-77
- C2 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
E
E
E
Q
Y
L
F
A
-
V
N
N
T
K
A
E
Y
P
R
D
----
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
----
K
H
L
V
H
L
--
I
H
N
I
Q
F
N
G
-
Q
V
--
E
I
F
E
E
D
T
I
K
I
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
-
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
-
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
-
I
T
L
P
--
P
T
Y
V
V
H
L
----
D
P
ERI---
L
S
--
I
Q
T
--------
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
------
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
-
A
T
T
W
V
-
A
T
K
E
T
I
G
H
--
S
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
D
-
E
-
N
L
Q
L
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
-
P
G
E
K
-
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
-
V
S
V
--
H
K
D
H
Q
E
Q
P
Y
-
L
C
A
Y
F
V
-
S
E
-
K
H
I
P
L
E
Q
------
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
65.54
36%
-67
- C2 -
1AMU
4
GRSA_ANEMI
A:
[28-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
N
T
K
A
E
Y
P
R
D
----
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
N
I
--
Q
F
N
G
Q
V
E
I
-
F
E
--
E
---
D
T
I
-
K
I
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
-
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
-
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
-
I
T
L
P
--
P
T
Y
V
V
H
L
----
D
P
ERI---
L
S
--
I
Q
T
--------
L
I
T
A
G
S
A
T
S
P
S
L
V
-
N
K
W
K
E
--
K
---
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
-
A
T
T
W
V
A
T
K
-
E
T
I
G
H
--
S
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
D
E
N
-
L
Q
-
L
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
P
G
E
-
K
-
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
-
V
S
V
H
K
D
H
Q
E
Q
P
--
Y
-
L
C
A
Y
F
V
-
S
E
K
H
I
P
L
-
E
Q
------
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
64.16
27%
-59
- C2 -
4DG9
1
?
A:
[18-604]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
-
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
--
D
---
C
S
T
T
-
P
T
P
A
N
-
G
L
---
P
--
C
V
P
--
V
-
R
H
--
L
P
A
--
A
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
------------------
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
---
R
L
C
L
G
Q
-
S
--
F
L
-
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
L
-
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
-----
L
F
N
T
L
V
D
L
D
---
P
D
C
---
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
----
H
V
R
--
R
-
A
L
L
R
H
P
R
L
H
L
--
V
N
G
Y
G
P
T
E
N
T
---
T
F
T
C
C
H
V
V
-
T
D
---
D
--
D
L
E
E
D
D
--
I
P
I
G
K
--
A
I
A
G
T
A
--
V
L
L
L
--
D
E
-
H
--
G
Q
EI
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
--
V
E
L
P
-
Y
-
R
-
G
R
L
L
R
A
--
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
-
G
V
K
Q
L
L
C
A
W
T
-------------
G
K
A
D
---
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
----------
E
L
D
P
D
Q
R
G
C
A
-
Q
L
W
S
E
L
L
G
C
---
E
V
G
A
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
-
S
A
G
A
G
A
N
L
G
L
A
D
L
Q
A
N
S
R
L
D
Q
F
S
R
L
L
R
S
H
G
L
A
P
E
R
L
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
63.66
36%
-66
- C2 -
1AMU
4
GRSA_ANEMI
A:
[24-530]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
F
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
-
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
-
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
--
T
---
Q
K
H
L
V
H
L
I
H
N
-
I
Q
---
F
N
G
Q
V
E
--
I
F
E
E
DT
I
K
I
--
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
S
-----------------------
P
K
G
T
M
L
E
H
K
G
I
S
---
N
L
K
V
F
F
E
N
--
S
L
-
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
-----
Y
V
V
H
L
D
P
------
E
R
---
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
----
L
V
N
--
K
-
W
K
E
---
K
V
T
Y
--
I
N
A
Y
G
P
T
E
T
T
---
I
C
A
T
T
W
V
A
-
T
K
E
--
T
--
I
G
--
H
S
--
V
P
I
G
A
--
P
I
Q
N
T
Q
--
I
Y
I
V
--
D
E
N
L
--
Q
L
--
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
--
V
D
N
P
-
F
V
P
-
G
--
E
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
-
Q
P
Y
L
C
A
Y
F
V
S
E
K
--
H
------
I
P
L
E
---
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.60
29%
-64
- C2 -
4DG9
1
?
A:
[19-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
-
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
DC
S
---
T
T
P
T
P
A
N
G
----
L
---
P
--
C
V
P
--
V
-
R
H
--
L
P
A
--
A
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
------------------
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
---
R
L
C
L
G
Q
-
S
--
F
L
-
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
-
C
C
V
L
N
D
L
G
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
-----
L
F
N
T
L
V
D
L
D
---
P
D
C
---
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
----
H
V
R
R
A
L
-
L
----
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
---
T
F
T
C
C
H
V
V
-
T
D
---
D
D
L
E
E
--
D
D
--
I
P
I
G
K
--
A
I
A
G
T
A
--
V
L
L
L
D
E
H
G
-
Q
--
E
I
--
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
--
V
E
L
P
-
Y
-
R
-
G
--
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
-
G
-
V
K
Q
L
L
C
A
W
T
G
K
A
--
D
------
A
S
P
Q
---
A
L
L
R
Q
----
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
-
L
R
R
L
E
----------
L
D
P
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
-
E
V
G
A
--
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
G
-
A
G
A
N
L
G
L
A
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
63.22
34%
-69
- C2 -
2JGP
5
A:
[1-520]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
E
Y
V
A
P
R
S
V
W
E
A
R
L
A
-
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
-
N
E
-
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
T
R
V
E
A
A
F
Q
R
L
I
A
R
H
E
S
L
R
T
S
F
A
V
V
N
-
G
E
P
V
Q
N
I
H
E
D
V
P
F
A
----
L
A
Y
S
E
-
V
T
E
--------
E
E
A
R
--
E
L
V
S
-------
S
L
V
Q
P
F
D
L
E
V
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
-
L
F
T
-
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
W
----
V
Q
L
Y
Q
G
D
-
V
-----
L
P
E
L
R
I
Q
Y
K
D
F
A
V
W
Q
Q
E
F
S
Q
S
A
----
A
F
H
----
K
Q
E
A
Y
W
---
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
---
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
-------
S
T
E
E
V
M
T
L
-----
P
E
C
T
L
A
P
F
--
M
T
DE
T
G
Q
H
--
A
K
F
D
L
T
F
S
A
T
E
E
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
-
R
L
G
E
I
D
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
62.91
35%
-70
- C2 -
2JGP
5
A:
[3-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
V
A
P
R
S
V
W
E
A
R
L
A
-
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
-
N
E
-
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
T
R
V
E
A
A
F
Q
R
L
I
A
R
H
E
S
L
R
T
S
F
A
V
V
N
-
G
E
P
V
Q
N
I
H
E
D
V
P
F
A
----
L
A
Y
S
E
-
V
T
E
--------
E
E
A
R
--
E
L
V
S
-------
S
L
V
Q
P
F
D
L
E
V
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
-
L
F
T
-
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
W
----
V
Q
L
Y
Q
G
D
-
V
-----
L
P
E
L
R
I
Q
Y
K
D
F
A
V
W
Q
Q
E
----
F
S
Q
S
A
A
F
H
----
K
Q
E
A
Y
W
---
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
---
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
-------
S
T
E
E
V
M
T
L
-----
P
E
C
T
L
A
P
F
M
T
D
E
--
T
G
Q
H
--
A
K
F
D
L
T
F
S
A
T
E
E
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
-
V
Q
N
P
H
I
R
L
G
E
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.44
32%
-54
- C2 -
3VNS
2
?
A:
[37-533]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
-
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
GE
P
---
H
E
G
C
A
V
T
R
V
V
-
R
T
---
A
--
A
V
A
--
E
-
C
K
--
D
A
E
--
P
-----
A
P
G
P
G
A
E
D
M
A
Y
V
I
Y
T
S
G
-------------------
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
---
A
L
L
A
G
A
-
P
--
S
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
-----
A
F
L
A
L
T
E
A
A
---
V
R
G
GRD
V
S
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
ML
R
P
W
A
K
--
A
-
F
G
L
D
--
R
P
R
L
--
V
N
G
Y
G
I
T
E
T
T
---
V
F
T
T
F
E
E
I
-
T
E
---
A
Y
L
A
Q
--
D
A
--
S
I
I
G
R
AL
P
S
F
G
T
R
--
V
V
G
D
--
D
G
----
R
D
--
V
A
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
PE
V
-------------
V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
V
T
V
R
E
F
K
-
P
G
D
L
R
L
V
C
A
Y
V
A
R
E
G
S
A
------
T
T
A
R
---
E
L
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.35
32%
-55
- C2 -
3VNQ
1
?
A:
[37-533]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
-
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
-
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
GE
P
---
H
E
G
C
A
V
T
R
V
V
-
R
T
---
A
--
A
V
A
--
E
-
C
K
--
D
A
E
--------
A
P
G
P
G
A
E
D
M
A
Y
V
I
Y
T
S
G
T
------------------
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
---
A
L
L
A
G
A
-
P
--
S
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
-----
A
F
L
A
L
T
E
A
A
---
V
R
G
GRD
V
S
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
ML
R
P
W
A
K
--
A
-
F
G
L
D
--
R
P
R
L
--
V
N
G
Y
G
I
T
E
T
T
---
V
F
T
T
F
E
E
I
-
T
E
---
A
Y
L
A
Q
--
D
A
--
S
I
I
G
R
AL
P
S
F
G
T
R
--
V
V
G
D
--
D
G
----
R
D
--
V
A
P
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
PE
V
-------------
V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
V
V
T
V
R
E
F
K
-
P
G
D
L
R
L
V
C
A
Y
V
A
R
E
G
S
A
------
T
T
A
R
---
E
L
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
62.23
34%
-64
- C2 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
-
E
E
E
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
-
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E-
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
-
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
--
T
---
Q
K
H
L
V
H
L
I
H
N
-
I
-------
Q
F
N
---
G
Q
V
--
E
I
F
--
E
E
D
-----------
T
I
K
I
R
-----EGTNLHVPSKSTDLA
Y
V
I
Y
T
S
P
K
G
T
M
L
E
H
K
G
I
S
---
N
L
K
V
F
F
-
E
NS
L
N
--
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
-----
Y
V
V
H
L
-------
D
P
E
RI--
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
----
L
V
N
--
K
-
W
K
E
K
V
---
T
Y
--
I
N
A
Y
G
P
T
E
T
T
---
I
C
A
T
T
W
V
A
T
K
E
---
T
--
I
G
--
H
S
--
V
P
I
G
A
--
P
I
Q
N
T
Q
--
I
Y
I
V
--
D
E
--NL
Q
L
--
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
--
V
D
N
P
-
F
-
V
P
G
--
E
K
L
--
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
-
Q
E
Q
P
Y
L
C
A
Y
F
V
S
E
K
--
H
------
I
P
L
E
---
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.63
29%
-64
- C2 -
4DG8
3
?
A:
[19-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
-
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
-
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
---
T
T
P
T
P
A
N
G
----
L
---
P
--
C
V
P
--
V
-
R
H
--
L
P
A
--
A
P
A
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
------------------
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
---
R
L
C
L
G
Q
-
S
--
F
L
-
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
-
C
C
V
L
N
D
L
G
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
-----
L
F
N
T
L
V
D
L
D
---
P
D
C
---
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
----
H
V
R
R
A
L
-
L
----
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
---
T
F
T
C
C
H
V
V
-
T
D
---
D
D
L
E
E
--
D
D
--
I
P
I
G
K
--
A
I
A
G
T
A
--
V
L
L
L
D
E
H
G
-
Q
--
E
I
--
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
--
V
E
L
P
-
Y
-
R
-
G
--
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
-
G
-
V
K
Q
L
L
C
A
W
T
G
K
A
--
D
------
A
S
P
Q
---
A
L
L
R
Q
----
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
-
L
R
R
L
E
E
-
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.62
35%
-69
- C2 -
2JGP
5
A:
[4-509]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
A
P
R
S
V
W
E
A
R
L
A
-
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
-
N
E
-
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
T
R
V
E
A
A
F
Q
R
L
I
A
R
H
E
S
L
R
T
S
F
A
V
V
N
-
G
E
P
V
Q
N
I
H
E
D
V
--
P
----
F
A
L
A
Y
-
S
E
V
--------
T
E
E
E
A
R
E
L
V
S
-------
S
L
V
Q
P
F
D
L
E
V
A
P
L
I
R
V
S
L
L
K
I
-
G
E
D
R
Y
V
L
F
T
-
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
W
----
V
Q
L
Y
Q
G
D
-
V
-----
L
P
E
L
R
I
Q
Y
K
D
F
A
V
W
Q
Q
E
----
F
----
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
---
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
---
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
-------
S
T
E
E
V
M
T
L
-----
P
E
C
T
L
A
P
F
--
M
T
--
D
E
T
G
QH
A
K
F
D
L
T
F
S
A
T
E
E
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
60.66
27%
-61
- C2 -
3E7W
2
DLTA_BACSU
A:
[2-502]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
S
-
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
I
Q
K
R
I
S
G
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
G
A
E
L
L
I
--
H
---
A
A
G
L
S
I
D
A
V
G
Q
Q
I
---
Q
--
T
V
S
--
A
-
E
E
--
L
L
E
NE
G
G
S
V
S
Q
D
Q
W
V
K
E
H
E
T
F
Y
I
I
Y
T
S
G
S
------------------
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
---
S
F
T
D
W
I
C
A
--
D
F
-
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
-----
F
V
Q
M
C
L
M
D
P
GFS
Q
D
L
---
L
P
H
A
D
T
F
M
F
C
G
E
V
L
P
V
S
----
V
A
K
--
A
-
L
L
E
R
F
P
K
A
K
I
--
F
N
T
Y
G
P
T
E
A
T
---
V
A
V
T
S
V
E
I
-
T
N
D
V
I
S
--
R
S
--
E
S
--
L
P
V
G
F
--
A
K
P
D
M
N
--
I
F
I
M
--
D
E
E
G
--
Q
P
--
L
P
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
--
F
S
H
E
-----
G
--
Q
W
A
--
Y
R
T
G
D
A
G
F
I
-
Q
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
P
N
G
T
-
V
E
Y
L
I
A
A
I
V
P
E
E
--
H
EFEK
E
F
Q
L
T
S
---
A
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.53
35%
-57
- C2 -
4D56
5
?
A:
[30-516]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
-
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
-
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
--
T
QTQ
W
S
N
L
I
S
D
Y
Q
G
-
Q
V
---
I
--
C
L
D
SQ
W
-
A
K
--
I
A
S
--
Y
S
Q
E
N
L
V
N
T
V
N
P
E
N
L
A
Y
V
I
Y
T
S
G
S
------------------
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
-
Y
--
Q
I
-
T
T
S
D
R
T
L
Q
F
V
S
--
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
-
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
---
I
A
L
---
P
D
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
----
L
V
R
--
M
W
F
K
N
V
G
N
F
P
E
L
--
I
N
V
Y
G
P
T
E
G
T
IAV
S
L
C
R
L
S
Q
L
-
T
E
---
S
--
Q
R
--
N
R
TE
I
P
I
G
K
--
S
-
L
G
E
N
I
S
V
Y
V
L
D-
E
T
-
L
--
K
T
--
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
--
I
Q
D
P
F
S
-
P
-
S
--
E
R
L
--
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
---------
R
L
V
A
Y
L
V
P
H
--
S
------
T
E
E
N
L
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.20
31%
-63
- C2 -
3DHV
2
DLTA_BACCR
A:
[16-498]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
A
T
A
V
T
V
T
D
L
P
V
R
I
V
S
E
D
N
L
K
D
I
F
F
--
T
H
K
G
N
T
P
-------
N
P
E
H
A
V
K
G
D
E
N
-
F
Y
I
I
Y
T
S
-----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
-
L
M
----
E
A
------
S
F
--
S
E
S
MLPNMK
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
-
K
L
I
E
R
--
F
P
K-
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
-
V
T
-
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
-
G
T
-
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
--
I
D
-
G
E
-
R
-
A
Y
K
T
G
D
-
A
G
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
--
Y
-
L
L
A
V
V
V
P
G
E
-
H
S
F
E
-
K
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.78
31%
-62
- C2 -
3FCE
1
DLTA_BACCR
A:
[16-498]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
A
T
A
V
T
V
T
D
L
P
V
R
I
V
S
E
D
N
L
K
D
I
F
F
--
T
H
K
G
N
T
P
-------
N
P
E
H
A
V
K
G
D
E
N
-
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
-
L
M
----
E
A
------
S
F
--
S
E
S
MLPNMK
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
-
K
L
I
E
R
--
F
P
K-
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
-
V
T
-
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
-
G
T
-
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
--
I
D
-
G
E
-
R
-
A
Y
K
T
G
D
-
A
G
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
--
Y
-
L
L
A
V
V
V
P
G
E
-
H
S
F
E
-
K
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
59.67
31%
-64
- C2 -
3FCC
1
DLTA_BACCR
A:
[16-498]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
I
S
S
E
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
E
N
S
G
A
K
L
L
L
S
A
T
A
V
T
V
T
D
L
P
V
R
I
V
S
E
D
N
L
K
D
I
F
F
--
T
H
K
G
N
T
P
-------
N
P
E
H
A
V
K
G
D
E
N
-
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
F
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
-
L
M
----
E
A
------
S
F
--
S
E
S
MLPNMK
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
-
K
L
I
E
R
--
F
P
K-
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
-
V
T
-
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
-
G
T
-
I
A
P
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
--
I
D
-
G
E
-
R
-
A
Y
K
T
G
D
-
A
G
Y
V
E
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
I
K
-
K
G
E
K
Y
D
--
Y
-
L
L
A
V
V
V
P
G
E
-
H
S
F
E
-
K
E
F
K
L
T
S
A
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------