@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0177: (2016-03-13 )
MKHQETTSQQYNFSIIKHGDISTPQGFTAGGMHIGLRANKKDFGWIYSSSLASSAAVYTLNQFKAAPLIVTEDTLQKSKGKLQALVVNSANANSCTGQQGIDDARQTQTWVAQQLQIPSEHVAVASTGVIGEYLPMDKIKTGTEHIKDTNFATPGAFNEAILTTDTCTKHIAVSLKIDGKTVTIGGSAKGSGMIHPNMATMLAFITTDASIESNTLHQLLKSSTDHTFNMITVDGDTSTNDMVLVMANHQVEHQILSQDHPQWETFVDAFNFVCTFLAKAIARDGEGATKLISVNVSGAKSISDARKIGKTIVSSNLVKSAIFGEDANFGRIITAIGYSGCEIDPKCTYVQLNQIPVVDKGMAVLFDEQAMSNTLTHEHVTIDVQLGLGNAAATAYGCDLSYDYVRINASYRT
Atome Classification :
(20 SA)
.........10........20........30.......-.-40........50........60........70........80........90........100.......110.......120.......130.......140.....-..150........160-.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.....-....350......------.360.....---..370....-.-..380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKHQETTSQQY
N
F
S
I
I
KHGDISTPQGFTAG
G
M
H
I
G
L
RA-N-KK
D
F
G
W
I
YSSSLASS
A
A
V
Y
T
L
N
QFKAA
P
L
I
V
T
E
D
T
L
Q
KSKG
K
L
Q
A
L
V
V
NSANANSCTGQQGI
D
D
A
R
Q
T
Q
T
W
V
A
Q
Q
LQIPSE
H
V
A
V
ASTGVIGEYLP
M
D
KIKT
G
T
E
HIK-DTNF-ATPGAFN
E
A
---
I
L
TTDTCT
K
H
I
A
V
S
L
K
IDG
K
T
V
T
IGGSAKGS
G
M
IHP
N
M
A
T
M
L
A
F
I
TTDASI
E
S
N
T
L
H
Q
L
L
K
SSTD
H
T
F
N
M
I
T
VDGDTSTN
D
M
V
L
V
MANH
Q
V
E
H
Q
I
L
SQDHP
Q
W
E
T
F
V
D
A
F
N
F
V
C
T
F
L
A
K
A
I
ARDGEG
A
T
K
L
I
S
V
NVSGAK
S
I
S
D
A
R
K
I
G
K
T
I
V
S
S
N
L
V
K
S
A
IFGEDANF
G
R
I
I
T
AIGYSG--CEIDP-K
C
T
Y
V
Q
LNQIPVV------DKG
M
A
V
L
F
D
---
E
Q
AMSNTLT-H-
E
H
V
T
I
D
V
Q
LGLGNAA
A
T
A
YGCD
L
S
Y
D
Y
V
R
I
NASYRT
24
PsiBlast_CBE
98.32
35%
-81
- C7 -
1VZ6
2
GNAT2_STRCL
B:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
23
PsiBlast_CBE
97.80
35%
-82
- C7 -
1VZ7
1
GNAT2_STRCL
B:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
1
PsiBlast_PDB
97.73
35%
-82
- C7 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
2
PsiBlast_PDB
97.57
35%
-81
- C7 -
1VZ7
1
GNAT2_STRCL
A:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
68
Fugue
97.37
35%
-78
- C7 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
D
G
-
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
A
D
--
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
A
G
E
-
G
G
F
D
R
A
A
R
A
---
I
M
T
T
D
T
R
P
K
E
V
R
V
S
V
G
----
G
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
------
P
P
D
---
D
A
L
---
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
45
HHSearch
97.21
35%
-76
- C7 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
A
D
--
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
-
W
P
A
G
E
G
G
F
D
R
A
A
R
A
---
I
M
T
T
D
T
R
P
K
E
V
R
V
S
V
G
----
G
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
G
E
V
-------
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
E
R
-
V
T
I
R
F
G
E
V
E
V
Y
------
P
P
------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
3
PsiBlast_PDB
96.96
35%
-84
- C7 -
1VZ8
3
GNAT2_STRCL
A:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
21
PsiBlast_CBE
95.09
35%
-79
- C7 -
1VZ7
1
GNAT2_STRCL
D:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
--
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
P
A
G
E
G
G
F
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
R
V
S
--
V
G
G
A
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
22
PsiBlast_CBE
94.14
35%
-79
- C7 -
1VZ7
1
GNAT2_STRCL
C:
[8-390]
----------------------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
--
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
--
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
---
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
---
E
H
L
K
-
T
L
E
W
-------
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
R
V
-------
T
L
V
--
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
46
HHSearch
77.99
52%
-111
- C7 -
1VRA
7
?
B:
[1-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
S
F
V
T
T
D
A
N
I
D
H
G
H
L
Q
G
A
L
S
A
I
T
N
E
T
F
N
R
I
T
V
D
G
D
T
S
T
N
D
M
V
V
V
M
A
S
G
L
A
E
N
E
T
L
T
P
E
H
P
D
W
A
N
F
Y
K
A
L
Q
L
A
C
E
D
L
A
K
Q
I
A
R
D
G
E
G
A
T
K
L
I
E
V
E
V
T
G
A
A
N
D
Q
E
A
G
M
V
A
K
Q
I
V
G
S
D
L
V
K
T
A
I
Y
G
A
D
A
N
W
G
R
I
I
C
A
I
G
Y
S
G
--
C
E
V
N
Q
E
T
-
I
D
I
A
I
G
P
I
V
T
L
------
K
Q
S
E
P
T
G
F
S
---
E
E
E
A
T
A
Y
L
K
E
A
-
D
P
V
K
I
S
V
N
L
H
I
G
N
G
T
G
K
A
W
G
C
D
L
T
Y
D
Y
V
R
I
N
A
G
Y
--
4
PsiBlast_PDB
77.54
49%
-114
- C7 -
1VRA
7
?
B:
[1-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
S
F
V
T
T
D
A
N
I
D
H
G
H
L
Q
G
A
L
S
A
I
T
N
E
T
F
N
R
I
T
V
D
G
D
T
S
T
N
D
M
V
V
V
M
A
S
G
L
A
E
N
E
T
L
T
P
E
H
P
D
W
A
N
F
Y
K
A
L
Q
L
A
C
E
D
L
A
K
Q
I
A
R
D
G
E
G
A
T
K
L
I
E
V
E
V
T
G
A
A
N
D
Q
E
A
G
M
V
A
K
Q
I
V
G
S
D
L
V
K
T
A
I
Y
G
A
D
A
N
W
G
R
I
I
C
A
I
G
Y
S
G
--
C
E
V
N
Q
-
E
T
I
D
I
A
I
G
P
I
V
T
L
------
K
Q
S
E
P
T
G
F
S
---
E
E
E
A
T
A
Y
L
K
-
E
A
D
P
V
K
I
S
V
N
L
H
I
G
N
G
T
G
K
A
W
G
C
D
L
T
Y
D
Y
V
R
I
N
A
G
Y
--
5
PsiBlast_PDB
72.02
36%
-107
- C7 -
2VZK
-
?
B:
[1-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PPKARG
D
Q
A
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
Y
T
T
47
HHSearch
71.56
37%
-104
- C7 -
2V4I
-
?
B:
[182-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
G
E
V
-------
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
E
R
-
V
T
I
R
F
G
E
V
E
V
Y
------
P
P
------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
41
PsiBlast_CBE
70.38
33%
-106
- C7 -
3IT6
1
?
D:
[1-203]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
------
S
E
I
P
P
A
Q
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
T
L
D
P
-
D
R
I
S
V
S
F
N
G
A
A
V
C
------
V
H
G
V
G
A
------
P
G
A
R
E
V
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
Y
--
7
PsiBlast_PDB
70.12
35%
-107
- C7 -
2V4I
-
?
B:
[182-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP-------
D
D
A
L
-----
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
42
PsiBlast_CBE
70.05
33%
-100
- C7 -
3IT6
2
?
B:
[1-203]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
------
S
E
I
P
P
A
Q
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
T
L
D
P
-
D
R
I
S
V
S
F
N
G
A
A
V
C
------
V
H
G
V
G
A
------
P
G
A
R
E
V
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
Y
--
44
PsiBlast_CBE
69.20
33%
-104
- C7 -
3IT4
3
?
B:
[1-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
------
S
E
I
P
P
A
Q
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
T
L
D
P
-
D
R
I
S
V
S
F
N
G
A
A
V
C
------
V
H
G
V
G
A
------
P
G
A
R
E
V
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
---
49
HHSearch
69.09
51%
-33
- C7 -
1VRA
17
ARGJ_BACHD
A:
[19-208]
---------
T
A
N
V
L
K
L
E
T
G
S
V
T
S
A
K
G
F
S
A
V
G
I
H
T
G
V
K
R
-
K
-
R
K
D
L
G
A
I
V
C
E
V
P
A
S
S
A
A
V
Y
T
L
N
K
V
Q
A
A
P
L
K
V
T
Q
E
S
I
A
V
E
-
G
K
L
Q
A
M
I
V
N
S
G
I
A
N
A
C
T
G
K
R
G
L
D
D
A
Y
T
M
R
A
V
G
A
E
T
F
H
I
P
E
H
Y
V
A
V
T
S
T
G
V
I
G
E
F
L
P
M
D
V
I
T
N
G
I
R
Q
L
K
-
P
E
A
T
I
E
G
A
H
A
F
N
E
A
---
I
L
T
T
D
T
V
E
K
H
T
C
Y
Q
T
I
V
N
G
K
T
V
T
V
G
G
V
A
K
G
S
G
M
I
H
P
N
M
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.58
36%
-107
- C7 -
2YEP
1
?
F:
[1-212]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
------
L
A
G
E
V
D
A
G
E
-
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
D
I
D
Q
-
E
R
V
T
I
R
F
G
E
V
E
V
Y
PP--------------------
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
Y
T
-
43
PsiBlast_CBE
68.57
33%
-96
- C7 -
3IT4
2
?
D:
[1-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
------
S
E
I
P
P
A
Q
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
T
L
D
P
-
D
R
I
S
V
S
F
N
G
A
A
V
C
------
V
H
G
V
G
A
------
P
----
V
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
---