@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0179: (2016-03-13 )
MNSIIELTDYYSSNNYAPLKLVISKGKGVKVWDTDGKQYIDCISGFSVANQGHCHPTIVKAMTEQASKLSIISRVLYSDNLGKWEEKICHLAKKDKVLSLNSGTEAVEAAIKIARKWGSEVKGITDGQVEIIAMNNNFHGRTLGSLSLSNHDAYKAGFHPLLQGTTTVDFGDIEQLTQAISPNTAAIILEPIQGEGGVNIPPKGYIQAVRQLCDKHQILMIADEIQVGLGRTGKWFAMEWEQVVPDIYILGKALGGGLYPVSAVLANNDVMRVLTPGTHGSTFGGNPLAIAISTAALDVLKDEQLVERSERLGSFLLKALLQLKHPSIKEIRGRGLFIGIELNTDAAPFVDQLIQRGILCKDTHRTIIRLSPPLVIDKEEIHQIVAAFQDVFKN
Atome Classification :
(56 SA)
---------.........10---........20........30........40........50.-.-......60...--.....70...-......80........-90----.--..---.---.--....100.......110.......120.......130.......140.......150..-...-..-.160.......170-----.---------------------.---------------------.......180----.-..------......190........200.......210.......220.......230.......240.........250......-.260.......270......------.280.......290.......300.......310....---...320.--.--.....330.......340----..----.----.---.--..350.-----------.-....----------------------.360---------.-......370.......380.......390..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MNS
I
I
E
L
T
D
YY---SSNNY
A
P
L
K
L
V
I
SKGK
G
V
K
V
WDTD
G
K
Q
Y
I
D
C
ISGFSVANQG-H-C
H
P
T
I
V
K
A
M
T
E
--
Q
A
S
K
L
S
-
I
I
S
-
R
V
L
YSDNL
G
K
W
E
E
K
I
C
-
H
-----
L
--
A
K---K---
D
--
K
V
L
SLNSG
T
E
A
V
E
A
A
I
K
I
A
R
K
WGSEVKGITDG
Q
V
E
I
I
A
MNNNFH
G
R
T
L
G
S
L
SLSN-H
D
A
-
Y
K
A-G
F
-
H
P
LLQGTTTVDF-------G---------------------
D
---------------------
I
E
Q
L
T
Q
AI------S-PN------
T
A
A
I
I
L
E
P-IQGEGGVNIP
P
K
G
Y
I
Q
A
V
R
Q
L
CDKH
Q
I
L
M
I
A
D
E
I
Q
VGLGRTG
K
W
F
A
M
E
W
--
E
Q
VVP
D
I
Y
I
L
G
K
A
LGGG
L
-
Y
P
V
S
A
V
LANN
D
V
M
R
V
LTPGT------HGSTFGG
N
P
L
A
I
A
I
S
T
A
A
L
D
VL
K
D
E
Q
L
V
E
R
S
E
R
L
G
S
F
L
---
L
K
A
L
L
Q
L--K--HP
S
I
K
E
IRGR
G
L
F
I
G
I
E
L----NT----D----
A
---
A
--
P
F
V
D
Q
L
-----------
I
-QRGI----------------------LCKD---------T-H
R
T
I
I
RLSP
P
L
V
I
D
K
E
E
I
H
Q
I
V
A
A
F
Q
D
V
FKN-
111
HHSearch
90.72
45%
-101
- C1 -
2OAT
2
OAT_HUMAN
A:
[42-438]
-----------
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
------
Q
D
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
TKDW
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
-
112
HHSearch
87.06
43%
-105
- C1 -
1Z7D
-
OAT_PLAYO
A:
[11-407]
-----------
D
Y
I
N
N
E
L
K
Y
---
G
A
H
N
Y
D
P
I
P
V
V
L
K
R
A
K
G
V
F
V
Y
D
V
N
D
K
R
Y
Y
D
F
L
S
A
Y
S
S
V
N
Q
G
-
H
-
C
H
P
N
I
L
N
A
M
I
N
--
Q
A
K
N
L
T
-
I
C
S
-
R
A
F
F
S
V
P
L
G
I
C
E
R
Y
L
T
-
N
-----
L
--
L
G
---
Y
---
D
--
K
V
L
M
M
N
T
G
A
E
A
N
E
T
A
Y
K
L
C
R
K
W
G
Y
E
V
K
K
I
P
E
N
M
A
K
I
V
V
C
K
N
N
------------------------------
Q
F
S
K
V
P
Y
-------
D
---------------------
D
---------------------
L
E
A
L
E
E
E
L
------
K
D
P
N
------
V
C
A
F
I
V
E
P
-
I
Q
G
E
A
G
V
I
V
P
S
D
N
Y
L
Q
G
V
Y
D
I
C
K
K
Y
N
V
L
F
V
A
D
E
V
Q
T
G
L
G
R
T
G
K
L
L
C
V
H
H
--
Y
N
V
K
P
D
V
I
L
L
G
K
A
L
S
G
G
H
-
Y
P
I
S
A
V
L
A
N
D
D
I
M
L
V
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
A
A
S
I
C
V
E
A
L
N
V
L
I
N
E
K
L
C
E
N
A
E
K
L
G
G
P
F
---
L
E
N
L
K
R
E
L
K
D
--
S
K
I
V
R
D
V
R
G
K
G
L
L
C
A
I
E
F
----
K
N
ELV-
N
----
V
---
L
--
D
I
C
L
K
L
-----------
K
-
E
N
G
L
----------------------
I
T
R
D
---------
V
-
H
D
K
T
I
R
L
T
P
P
L
C
I
T
K
E
Q
L
D
E
C
T
E
I
I
V
K
T
V
K
--
23
PsiBlast_CBE
86.47
45%
-97
- C1 -
1OAT
1
OAT_HUMAN
C:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
22
PsiBlast_CBE
85.63
45%
-97
- C1 -
2OAT
2
OAT_HUMAN
B:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
4
PsiBlast_PDB
85.32
45%
-97
- C1 -
2CAN
2
OAT_HUMAN
A:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
2
PsiBlast_PDB
85.19
45%
-97
- C1 -
1OAT
2
OAT_HUMAN
A:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
24
PsiBlast_CBE
85.10
45%
-96
- C1 -
1OAT
2
OAT_HUMAN
B:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
27
PsiBlast_CBE
84.99
45%
-100
- C1 -
1GBN
1
OAT_HUMAN
C:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
26
PsiBlast_CBE
84.98
45%
-97
- C1 -
2CAN
2
OAT_HUMAN
B:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
6
PsiBlast_PDB
84.71
45%
-95
- C1 -
2BYJ
2
OAT_HUMAN
A:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
3
PsiBlast_PDB
84.66
45%
-97
- C1 -
2OAT
2
OAT_HUMAN
A:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
25
PsiBlast_CBE
84.62
45%
-97
- C1 -
2CAN
1
OAT_HUMAN
C:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
31
PsiBlast_CBE
84.43
44%
-98
- C1 -
2BYL
1
OAT_HUMAN
C:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
A
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
32
PsiBlast_CBE
84.32
44%
-98
- C1 -
2BYL
2
OAT_HUMAN
B:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
A
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
30
PsiBlast_CBE
84.31
45%
-95
- C1 -
2BYJ
2
OAT_HUMAN
B:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
29
PsiBlast_CBE
84.26
45%
-95
- C1 -
2BYJ
1
OAT_HUMAN
C:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
5
PsiBlast_PDB
84.08
45%
-99
- C1 -
1GBN
2
OAT_HUMAN
A:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
28
PsiBlast_CBE
83.99
45%
-99
- C1 -
1GBN
2
OAT_HUMAN
B:
[4-392]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
7
PsiBlast_PDB
83.59
44%
-97
- C1 -
2BYL
2
OAT_HUMAN
A:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
A
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
114
HHSearch
82.78
41%
-96
* C1 *
1VEF
2
ARGD_THET8
A:
[24-395]
---------------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
--
L
P
PE-
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
--
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
-----------
E
K
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
--
21
PsiBlast_CBE
82.10
45%
-97
- C1 -
2OAT
1
OAT_HUMAN
C:
[41-429]
----------
D
D
I
F
E
R
E
Y
K
Y
---
G
A
H
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
S
--
Q
V
D
K
L
T
-
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
-
K
-----
L
--
F
N
---
Y
---
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
-
S
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
-------
N
---------------------
D
---------------------
L
P
A
L
E
R
A
L
Q-----
D
-
P
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
--
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
------
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
KETK
D
W
----
D
----
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
-
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
----------
101
Fugue
81.41
41%
-100
- C1 -
2OAT
2
OAT_HUMAN
A:
[36-439]
GPPT
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
--------
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
-
H
-
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
L
---
T
-
L
T
S
R
A
-
F
Y
N
N
V
L
G
E
Y
E
E
Y
-----
I
--
T
K
---
L
F
NY
H
--
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
Q
K
Y
K
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
-
D
P
T
S-
Y
D
-
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
ND
L
P
A
L
E
R
---------------------
A
---------------------
L
Q
D
P
-------------
N
------
V
A
A
F
M
V
E
P
-
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
EN--
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
-
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
--GE----
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
L
--
P
--
S
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
E
----
T
KDWD
A
---
W
--
K
V
C
L
R
L
-----------
R
-
D
N
G
L
----------------------
L
A
K
P
---------
T
H-
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
14
PsiBlast_PDB
77.75
38%
-90
- C1 -
1VEF
2
ARGD_THET8
A:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
L
P
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E
----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
116
HHSearch
77.50
37%
-96
- C1 -
2ORD
15
ARGD_THEMA
A:
[14-396]
-------------------
Y
---
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
-
H
-
S
H
P
R
L
V
E
A
I
K
D
--
Q
A
E
K
L
I
-
H
C
S
-
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
-
K
-----
N
--
T
F
---
G
---
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
-
K
--
K
S
E
K
K
Y
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
-
Q
P
K
-
Y
Q
K
-
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
-------
N
---------------------
N
---------------------
V
E
D
L
R
R
K
M
------
S
-
E
D
------
V
C
A
V
F
L
E
P
-
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
--
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
--
V
P
I
G
A
V
I
V
N
E
R
A
-
N
V
L
E
P
G
D
------
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
---
M
K
K
L
Q
E
M
K
E
E
--
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
E
EV--
S
----
N
---
R
--
E
V
A
T
K
C
-----------
F
-
E
N
K
L
----------------------
L
V
V
P
---------
A
-
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
-
16
PsiBlast_PDB
77.27
38%
-89
- C1 -
1WKH
2
ARGD_THET8
A:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
L
P
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E
----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
41
PsiBlast_CBE
77.05
38%
-90
- C1 -
1VEF
2
ARGD_THET8
B:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
LP
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
13
PsiBlast_PDB
75.18
47%
-89
- C1 -
4ZWM
12
?
A:
[44-420]
-------------------
Y
---
V
C
Q
N
Y
A
-
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
ID
P
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
17
PsiBlast_PDB
75.13
37%
-99
- C1 -
2EH6
2
ARGD_AQUAE
A:
[2-375]
-------------------
Y
---
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
-
H
-
A
Y
P
K
L
T
E
A
L
K
E
--
Q
V
E
K
L
L
-
H
V
S
-
N
-
L
Y
E
N
---
P
W
Q
E
E
L
A
-
H
K
L
V
K
H
F
--
W
T
---
E
---
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
G
--
K
N
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
-
Q
P
K
-
F
H
K
-
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
-------
N
---------------------
D
---------------------
I
D
S
V
Y
K
L
L
------
D
-
E
E
------
T
A
G
I
I
I
E
V
-
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
--
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
--
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
------
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
---
K
E
K
L
K
E
L
--
G
--
K
G
K
V
K
---
G
R
G
L
M
L
G
L
E
L
----
E
R
----
E
----
C
---
K
--
D
Y
V
L
K
A
-----------
L
-
E
K
G
L
----------------------
L
I
N
C
---------
T
-
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
---
125
HHSearch
75.11
35%
-101
- C1 -
2EH6
2
ARGD_AQUAE
A:
[2-375]
-------------------
Y
---
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
-
H
-
A
Y
P
K
L
T
E
A
L
K
E
--
Q
V
E
K
L
L
-
H
V
S
-
N
L
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
-
K
-----
H
--
F
W
T
--
E
---
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
---
K
G
K
N
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
-
Q
P
K
-
F
H
K
-
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
-------
N
---------------------
D
---------------------
I
D
S
V
Y
K
L
L
------
D
-
E
E
------
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
-
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
--
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
-
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
------
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
--
K
L
L
P
H
V
R
E
V
G
N
Y
F
---
K
E
K
L
K
E
L
--
G
--
K
G
K
---
V
K
G
R
G
L
M
L
G
L
E
L
----
E
R
----
E
----
C
---
K
--
D
Y
V
L
K
A
-----------
L
-
E
K
G
L
----------------------
L
I
N
C
---------
T
-
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
---
12
PsiBlast_PDB
75.10
47%
-85
- C1 -
4ZLV
5
?
A:
[44-420]
-------------------
Y
---
V
C
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
ID
P
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
15
PsiBlast_PDB
74.98
38%
-90
- C1 -
1WKG
2
ARGD_THET8
A:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
L
P
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E
----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
11
PsiBlast_PDB
74.83
47%
-87
- C1 -
4NOG
3
?
A:
[29-405]
-------------------
Y
---
V
C
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
ID
P
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
74
PsiBlast_CBE
74.09
36%
-94
- C1 -
2E54
5
ARGD_THEMA
A:
[2-383]
-------------------
Y
---
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
-
H
-
S
H
P
R
L
V
E
A
I
K
D
--
Q
A
E
K
L
I
-
H
C
S
-
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
-
K
-----
N
--
T
F
---
G
---
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
---
K
Y
G
K
K
K
S
E
K
K
Y
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
-
Q
P
K
-
Y
Q
K
-
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
-------
N
---------------------
N
---------------------
V
E
D
L
R
R
K
M
------
S
-
E
D
------
V
C
A
V
F
L
E
P
-
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
--
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
V
--
P
I
G
A
V
I
V
-
N
E
R
A
N
V
L
E
P
G
D
------
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
---
M
K
K
L
Q
E
M
--
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
E
----
E
----
V
---
S
N
R
E
V
A
T
K
C
-----------
F
-
E
N
K
L
----------------------
L
V
V
P
---------
A
-
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
--
37
PsiBlast_CBE
73.90
47%
-87
- C1 -
4ZWM
10
?
B:
[44-420]
-------------------
Y
---
V
C
Q
N
Y
A
-
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
ID
P
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
36
PsiBlast_CBE
73.63
47%
-86
- C1 -
4NOG
6
?
B:
[29-405]
-------------------
Y
---
V
C
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
ID
P
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
39
PsiBlast_CBE
73.33
38%
-87
- C1 -
1WKH
2
ARGD_THET8
B:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
LP
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
42
PsiBlast_CBE
73.13
37%
-99
- C1 -
2EH6
2
ARGD_AQUAE
B:
[2-375]
-------------------
Y
---
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
-
H
-
A
Y
P
K
L
T
E
A
L
K
E
--
Q
V
E
K
L
L
-
H
V
S
-
N
-
L
Y
E
N
---
P
W
Q
E
E
L
A
-
H
KLVKH
F
--
W
T
---
E
---
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
G
--
K
N
K
W
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
-
Q
P
K
-
F
H
K
-
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
-------
N
---------------------
D
---------------------
I
D
S
V
Y
K
L
L
------
D
-
E
E
------
T
A
G
I
I
I
E
V
-
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
--
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
V
--
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
------
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
--
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
---
K
E
K
L
K
E
L
--
G
--
K
G
K
V
K
---
G
R
G
L
M
L
G
L
E
L
----
E
R
----
E
----
C
---
K
--
D
Y
V
L
K
A
-----------
L
-
E
K
G
L
----------------------
L
I
N
C
---------
T
-
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
---
38
PsiBlast_CBE
72.85
47%
-88
- C1 -
4ZLV
6
?
B:
[44-420]
-------------------
Y
---
V
C
Q
N
Y
A
P
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
-
H
-
C
H
P
R
V
I
A
A
L
C
R
--
Q
A
E
R
L
T
-
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
-
E
-----
M
--
F
G
---
Y
---
D
--
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
V
K
E
I
P
P
D
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
-
Y
N
--
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
-------
D
---------------------
D
---------------------
V
G
A
L
E
E
A
L
K-----
D
-
P
N
------
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
--
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
-
V
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
P
G
T
------
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
RDC
L
R
R
E
L
Y
G
--
K
--
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S
----
D
----
A
IDP
N
--
D
V
V
M
K
L
-----------
K
-
E
N
G
I
----------------------
L
S
K
P
---------
T
-
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
---------------
40
PsiBlast_CBE
71.39
38%
-87
- C1 -
1WKG
2
ARGD_THET8
B:
[10-394]
----------
R
A
L
L
E
A
E
K
T
L
---
D
S
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
-
H
-
G
N
P
E
V
V
E
A
V
K
R
--
Q
A
E
T
L
M
-
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
-
A
-----
I
LP
P
E
---
L
---
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--------
H
T
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
-
E
P
K
-
Y
R
E
-
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
-------
N
---------------------
D
---------------------
V
E
A
L
K
R
A
V
------
D
-
E
E
------
T
A
A
V
I
L
E
P
-
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
--
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
--
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
------
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
I
--
P
--
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
E
----
K
----
A
---
A
--
P
Y
I
A
R
L
E----------
K
-
E
H
R
V
----------------------
L
A
L
Q
---------
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
---
77
PsiBlast_CBE
71.02
35%
-100
- C1 -
2EO5
3
?
A:
[6-416]
------------
I
I
E
E
S
D
I
Y
L
A
T
S
T
R
D
P
E
L
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
-
S
H
P
E
V
I
K
I
G
I
E
--
Q
M
Q
K
L
A
H
A
A
A
-
N
D
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
-
T
-----
Y
--
S
P
GN
F
Q
---
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
T
G
R
K
Y
---------
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
-
S
K
A
-
V
Q
R
-
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
-------
P
---------------------
N
PYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
------
F
-
V
N
LVPPEE
V
A
G
I
F
F
E
P
-
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
--
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
-
M
P
I
G
A
T
I
F
R
K
D
L
D
--
F
K
------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
--
L
L
P
H
V
N
E
I
G
K
I
F
---
A
E
E
L
Q
G
L
--
A
------
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
----
N
E
----
K
----
K
---
V
R
D
R
I
I
G
E
S
-----------
F
-
K
R
G
L
----------------------
L
L
L
P
---------
A
-
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
--
133
HHSearch
70.78
39%
-98
- C1 -
2EO5
3
?
A:
[24-416]
------------------------------
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
-
W
P
S
H
P
E
V
I
K
I
G
I
E
--
Q
M
Q
K
L
A
-
H
A
A
A
N
D
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
-
T
-----
Y
--
S
P
GN
F
Q
---
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-
T
--------
G
R
K
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
-
S
K
A
-
V
Q
R
S
I
V
-
G
P
F
M
P
G
V
I
H
V
P
Y
-------
P
NPYRNPWHINGYEN
P
S
E
L
V
N
R
V
---------------------
I
E
F
I
E
D
Y
I
FVNLVP
P
-
E
E
------
V
A
G
I
F
F
E
P
-
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
--
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
-
G
G
I
M
P
I
G
A
T
I
F
R
K
D
L
D
--
F
K
------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
---
A
E
E
L
Q
G
L
--
A
------
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
----
N
E
K
K
--
V
----
R
---
D
--
R
I
I
G
E
S
-----------
F
-
K
R
G
L
----------------------
L
L
L
P
---------
A
-
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
--
70
PsiBlast_CBE
70.54
35%
-88
- C1 -
4JEY
13
ARGD_SALTY
B:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
65
PsiBlast_CBE
70.50
36%
-91
- C1 -
2PB0
5
ARGD_SALTY
A:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
68
PsiBlast_CBE
69.99
35%
-87
- C1 -
4JF1
9
ARGD_SALTY
B:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
63
PsiBlast_CBE
69.90
36%
-91
- C1 -
2PB2
6
ARGD_SALTY
A:
[39-411]
------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
20
PsiBlast_PDB
69.46
36%
-91
- C1 -
4JEZ
14
ARGD_SALTY
A:
[39-411]
------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
71
PsiBlast_CBE
69.15
35%
-90
- C1 -
4JEY
14
ARGD_SALTY
A:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
64
PsiBlast_CBE
68.95
36%
-89
- C1 -
2PB0
5
ARGD_SALTY
B:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
72
PsiBlast_CBE
68.88
35%
-92
- C1 -
4JEX
17
ARGD_SALTY
B:
[37-411]
----------------------------
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
49
PsiBlast_CBE
68.72
36%
-90
- C1 -
4JEZ
13
ARGD_SALTY
B:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
66
PsiBlast_CBE
68.46
35%
-89
- C1 -
4JEW
13
ARGD_SALTY
B:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
67
PsiBlast_CBE
68.23
35%
-92
- C1 -
4JEW
12
ARGD_SALTY
A:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
69
PsiBlast_CBE
68.04
35%
-90
- C1 -
4JF1
9
ARGD_SALTY
A:
[36-411]
---------------------------
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
73
PsiBlast_CBE
67.19
35%
-91
- C1 -
4JEX
17
ARGD_SALTY
A:
[39-411]
------------------------------
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
-
H
-
C
H
P
A
L
V
E
A
L
K
S
--
Q
G
E
T
L
W
-
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
-
D
-----
A
--
T
F
---
A
---
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
--
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
-
Q
P
K
-
Y
S
D
-
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
-------
N
---------------------
D
---------------------
L
H
A
V
K
A
V
M
------
D
-
D
H
------
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
--
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
--
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
----
K
P
----
K
YKGR
A
---
R
--
D
F
L
Y
A
G
-----------
A
-
E
A
G
V
----------------------
M
V
L
N
---------
A
-
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
-------
75
PsiBlast_CBE
66.89
34%
-89
- C1 -
4PPM
3
?
B:
[418-844]
---------------------------------
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
-
H
-
N
P
Q
P
V
V
N
A
L
K
N
YL
D
A
Q
G
P
N
-
F
I
Q
-
Y
I
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
-
R
-----
L
--
A
P
---
G
---
N
MG
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
--------
S
T
G
K
P
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
-
R
D
K
-
H
R
R
-
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
-------
G
---------------------
D
---------------------
L
A
A
L
R
E
A
L
------
N
R
E
D
------
V
G
A
L
M
I
E
P
-
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
--
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
-
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
-
G
T
ADRFLV
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
---
K
Q
A
L
S
E
I
AA
R
--
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
D---------------------------WHTTWKFLPDP
V
-
Q
A
H
L
RAAMDRMEQALGEMFCMKFVTK
L
C
Q
D
HKILTFITA
N
-
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
----
76
PsiBlast_CBE
66.21
34%
-89
- C1 -
4PPM
3
?
A:
[418-844]
---------------------------------
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
-
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
P
N
-
F
I
Q
-
Y
I
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
-
R
-----
L
--
A
P
---
G
---
N
MG
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
--------
S
T
G
K
P
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
-
R
D
K
-
H
R
R
-
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
-------
G
---------------------
D
---------------------
L
A
A
L
R
E
A
L
------
N
R
E
D
------
V
G
A
L
M
I
E
P
-
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
--
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
-
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
-
G
T
ADRFLV
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
---
K
Q
A
L
S
E
I
A
A
R
--
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
D
Q
A-------------------------H
T
T
W
K
F
LP
D
P
-
V
-
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
C
M
K
F
V
T
K
L
C
Q
D
HK
I
L
T
F
I
T
A
N
-
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
----