@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0198: (2016-03-13 )
MSNLLEVNSLNVQFNYDETTVQAVKNVSFELRKKHILGIVGESGSGKSITAKSILGLLPDYPDHTLTGEIIFNGQSLNNLSTSALQQIRGKDISMIFQDPLSSLNPRLTIGKQITEVLFQHKRVSKSEAKSMTINILEKVGIKHATRQFDAYPHELSGGMRQRVMIAMALILKPQILIADEPTTALDASTQNQLLQLMKSLYEYTETSIIFITHDLGAVYQFCDDVIVMKDGSVVESGTVESIFKSPQHTYTKRLIDAIPDIHQTRPPRPLNNDILLKFDRVSVDYTSPSGSLYRAVNDINLAIRKGETLGIVGESGSGKSTLAKTVVGLKEVSEGFIWYNELPLSLFKDDELKSLRQEIQMIFQDPFASINPRFKVIDVIKRPLIIHGKVKDNDDIIKTVVSLLEKVGLDQSFLYRYPHELSGGQRQRVSIARALAVEPKVIVCDEAVSALDVSIQKDIIELLKQLQLDFGITYLFITHDMGVINEICDRVAVMKNGEIVELNNTEDIIKHPQSDYAKQLISEVAVIAK
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80.....----...90..--......100.......110.......120...-..------..130.......140.......150.......160.......170..--.....180.......190.......200.......210.......220.......------230.....-..240...--....250........-----260-.....----..270.......280.......290.......300.......310.......320.......330---------------------.......340.......350--------....---..--------...360-------------------------------------------------------------------------.....----------..370-----------------------------------------.--........-380.....---------------------..390----------.........400-----.......-410...-.....420.......430.......440-.........450.......460.......470.......480.......490....------...500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSN
L
L
E
V
N
S
L
N
V
Q
F
NYD
E
T
T
V
Q
A
V
K
N
V
S
F
E
L
R
K
K
H
I
L
G
I
VGESGSGK
S
I
T
A
K
S
I
L
G
LLPDYPDHT
L
T
G
E
I
I
FNGQSLNNL
S
T
S
A
L
Q
----
Q
I
RGK
D
I
--
S
M
I
F
QD
P
L
S
SLNPRL
T
I
G
K
Q
I
T
E
V
L
F
Q
H
KRVS-KS------EAK
S
M
T
I
N
I
L
E
K
VGI
K
H
A
T
R
QFDAY
P
H
E
LSG
G
M
R
Q
R
V
M
I
A
M
A
L
ILKP--
Q
I
L
I
ADEPTTALDAS
T
Q
N
Q
L
L
Q
L
M
K
S
L
Y
E
YTE
T
S
I
I
F
I
TH
D
L
G
A
V
Y
Q
F
CD
D
V
I
V
M------KDG
S
V
VES-G
T
V
E
S
I
F
K--SP
Q
H
T
Y
-
T
K
R
L
I
D
AI-----P
D
I
-HQTRP----PRPLNN
D
I
L
L
K
F
D
R
V
S
V
D
Y
TSPSGS
L
Y
R
A
V
N
D
I
N
L
A
I
RKG
E
T
L
G
I
VGESGS
G
K
S
T
L
A
K
T
V
V
G
L
K
E
---------------------VSEG
F
I
W
YNEL
P
L
S
LFK
D
----------
D
E
L
K
---
S
L
--------
R
Q
E
I
Q
M
-------------------------------------------------------------------------
I
F
QDP----------FAS-------------------------------------------I--NP
R
F
K
V
I
D
-
V
IKR
P
L
I
I
---------------------
H
G
K------------VKD
N
D
D
I
I
K
T
V
V
-----
S
L
L
E
KVG-L
D
-
Q
S
F
-
L
Y
RYPHELSGGQ
R
Q
R
V
S
I
A
R
ALAVEP---
K
V
I
V
CDE
A
V
S
A
L
D
V
S
I
Q
K
D
I
I
E
L
L
K
Q
L
Q
L
DFG
I
T
Y
L
F
I
THD
M
G
V
I
N
E
I
C
D
R
V
A
VMK------NG
E
I
V
E
LNN
T
E
D
I
I
KHP
Q
S
D
Y
A
K
Q
L
I
S
E
V
A
V
IAK
24
PsiBlast_CBE
82.24
40%
-117
- C3 -
3TUI
1
METN_ECOLI
H:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
26
PsiBlast_CBE
81.28
40%
-106
- C3 -
3TUI
1
METN_ECOLI
D:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
3
PsiBlast_PDB
80.08
40%
-112
- C3 -
3TUZ
1
METN_ECOLI
C:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
2
PsiBlast_PDB
79.93
40%
-107
- C3 -
3TUI
1
METN_ECOLI
C:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
21
PsiBlast_CBE
78.86
40%
-113
- C3 -
3TUZ
1
METN_ECOLI
H:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
22
PsiBlast_CBE
78.46
40%
-109
- C3 -
3TUZ
1
METN_ECOLI
G:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
23
PsiBlast_CBE
77.81
40%
-108
- C3 -
3TUZ
1
METN_ECOLI
D:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
25
PsiBlast_CBE
77.37
40%
-107
- C3 -
3TUI
1
METN_ECOLI
G:
[42-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
1
PsiBlast_PDB
75.58
40%
-106
- C3 -
3DHW
-
METN_ECOLI
C:
[19-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
---------------------
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
---
K
A
--------
R
R
Q
I
G
M
-------------------------------------------------------------------------
I
F
Q
H
-----------
F
N
L
-------------------------------------------
L
--
S
S
R
-
T
V
F
G
-
N
V
A
L
P
L
E
L
---------------------
D
N
T
------------
P
K
D
--
E
V
K
R
R
V
T
-----
E
L
L
S
L
V
G
-
L
G
-
D
K
H
--
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
---
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
------
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
--------
73
HHSearch
73.31
19%
-90
- C- -
2IW3
7
EF3A_YEAST
A:
[434-979]
----
E
D
L
C
N
C
E
F
S
L
A
Y
G
--
A
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
-------
D
G
F
P
T
------
Q
----
E
----------
E
C
R
T
--
V
Y
V
E
H
D
I
D
G
-
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
-----
V
----------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
--
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
----
C
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
-----
L
E
F
-
K
F
P
E
P
GYLE
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
T
---
S
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
---------------------
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q---------
H
A
F
A
---
H
I
ESHLDKT
P
S
E
Y
I
Q
W
-------------------------------------------------------------------------
R
F
Q
T
G
----------
E
D
R
ETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
-
N
I
G
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
G
Q
F
R
P
L
T
R
K
E
I
E
-----
E
H
C
S
M
L
G
-
L
D
-
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
------
D
G
R
M
T
P
S
---------------------------
82
HHSearch
71.84
28%
-106
- C3 -
1Z47
1
?
A:
[13-239]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
-
G
--
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
-----
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
----------
Q
K
R
N
V
--
G
L
V
F
Q
N
Y
A
--
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
-
V
P
-
K
D
------
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
---
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
--
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
E
--
K
P
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.60
37%
-97
- C3 -
4U02
1
?
C:
[15-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
---------------------
F
Q
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
----------
R
A
L
R
---
E
I
--------
R
R
E
V
G
M
-------------------------------------------------------------------------
V
F
Q
Q
------------
F
N
-------------------------------------------
L
--
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---------------------
R
R
W
------------
P
R
E
K
A
E
--
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
-
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----
27
PsiBlast_CBE
71.18
37%
-95
- C3 -
4U02
1
?
D:
[15-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
---------------------
F
Q
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
----------
R
A
L
R
---
E
I
--------
R
R
E
V
G
M
-------------------------------------------------------------------------
V
F
Q
Q
------------
F
N
-------------------------------------------
L
--
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---------------------
R
R
W
------------
P
R
E
K
A
E
--
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
-
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----
93
HHSearch
71.04
30%
-110
- C3 -
1OXX
22
?
K:
[2-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
---
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
---------------------
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
----------
L
I
V
P
---
P
E
--------
D
R
K
I
G
M
-------------------------------------------------------------------------
V
F
Q
T
W
----------
A
---------------------------------------------
L
--
Y
P
N
L
T
A
F
E
-
N
I
A
F
P
L
T
N
---------------------
M
K
-------------
M
-
S
K
E
E
I
R
K
R
V
E
-----
E
V
A
K
I
L
D
-
I
H
--
H
V
-
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
---
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
------
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
-----
6
PsiBlast_PDB
70.92
37%
-94
- C3 -
4U02
1
?
A:
[15-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
---------------------
F
Q
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
----------
R
A
L
R
---
E
I
--------
R
R
E
V
G
M
-------------------------------------------------------------------------
V
F
Q
Q
------------
F
N
-------------------------------------------
L
--
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---------------------
R
R
W
------------
P
R
E
K
A
E
--
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
-
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----
5
PsiBlast_PDB
70.66
37%
-92
- C3 -
4U00
3
?
A:
[15-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
---------------------
F
Q
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
----------
R
A
L
R
---
E
I
--------
R
R
E
V
G
M
-------------------------------------------------------------------------
V
F
Q
Q
------------
F
N
-------------------------------------------
L
--
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---------------------
R
R
W
------------
P
R
E
K
A
E
--
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
-
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----
29
PsiBlast_CBE
70.43
37%
-95
- C3 -
4U02
1
?
B:
[15-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
---------------------
F
Q
E
G
E
V
V
V
D
G
L
--
S
V
K
D
D
----------
R
A
L
R
---
E
I
--------
R
R
E
V
G
M
-------------------------------------------------------------------------
V
F
Q
Q
------------
F
N
-------------------------------------------
L
--
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---------------------
R
R
W
------------
P
R
E
K
A
E
--
K
K
A
L
-----
E
L
L
E
R
V
G
I
L
D
-
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
---
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
------
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----
91
HHSearch
70.32
33%
-110
- C3 -
2IT1
-
?
A:
[3-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
L
E
N
I
V
K
K
F
G
N
-----
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
---------------------
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
------------------
P
K
--------
D
R
N
V
G
L
-------------------------------------------------------------------------
V
F
Q
N
W
------------
A
-------------------------------------------
L
--
Y
P
H
M
T
V
Y
K
-
N
I
A
F
P
L
E
L
---------------------
R
K
-------------
A
-
P
R
E
E
I
D
K
K
V
R
-----
E
V
A
K
M
L
H
-
I
D
--
K
L
-
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
---
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
------
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
------
78
HHSearch
69.36
22%
-85
- C2 -
2R6F
3
?
A:
[449-944]
--------------------------------------------------------------------------------------------------------------
V
T
A
M
S
V
T
E
A
L
A
F
F
D
G
L
E
L
T
E
K
E
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
--
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
-
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
--
D
P
N
S
L
T
-
G
Q
Y
L
S
G
K
------
K
F
I
-
P
I
P
A
E
-----
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
----------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLE
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
-------------
S
---
N
P
--------
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTY
K
G
K
N
I
------------
A
-------------------------------------------
E
--
V
L
D
M
T
V
E
D
-
A
L
D
F
F
A
S
I
---------------------
P
--------------------
K
I
K
R
K
L
-----
E
T
L
Y
D
V
G
-
L
G
-
Y
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
PEGGDR
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
-----------------
74
HHSearch
69.33
23%
-89
- C2 -
1YQT
4
?
A:
[25-480]
-------
E
D
C
V
H
R
Y
G
-
V
--
N
A
F
V
L
Y
R
L
P
-
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
---
G
D
N
D
S
W
D
G
V
I
R
A
-
F
R
G
N
E
L
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
--
L
I
P
K
A
V
K
G
-
K
V
I
E
L
------
L
K
-
K
A
------
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
---
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
-
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
-
P
G
V
Y
-
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
-
L
R
G
Y
L
K
D
E
NVRFR
P
Y
E
I
K
F
T
K
T
GE--
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
S
------
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
---------------------
P
T
E
G
K
I
E
W
D
L
T
-------------------------------------
V
A
Y
-------------------------------------------------------------------------
K
P
Q
Y
I
----------
K
---------------------------------------------
A
--
D
Y
E
G
T
V
Y
E
-
L
L
S
K
I
D
A
S
---------------------
K
--------------
L
----
N
S
N
F
Y
K
T
-----
E
L
L
K
P
L
G
-
I
I
--
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
E
P
G
------------------------------
56
PsiBlast_CBE
60.11
33%
-108
- C3 -
1B0U
4
HISP_SALTY
A:
[19-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
---------------------
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
---
L
L
--------
R
T
R
L
T
M
-------------------------------------------------------------------------
V
F
Q
H
-----------
F
N
L
-------------------------------------------
W
--
S
H
M
T
V
L
E
N
-
V
M
E
A
P
I
Q
V
---------------------
L
G
L
------------
S
K
H
--
D
A
R
E
R
A
L
-----
K
Y
L
A
K
V
G
-
I
D
-
E
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
---
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
------
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
--------
70
PsiBlast_CBE
57.05
32%
-116
- C3 -
4HLU
2
ECFA2_THEMA
A:
[23-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
---------------------
P
T
S
G
D
V
L
Y
---------
D
----------
G
E
R
K
K
G
Y
E
I
--------
R
R
N
I
G
I
-------------------------------------------------------------------------
A
F
Q
Y
P
EDQF------
F
A
E
--------------------------------------------------
R
V
F
D
-
E
V
--
A
F
A
V
---------------------
K
N
F
------------
Y
P
D
R
D
P
-
V
P
L
V
K
-----
K
A
M
E
F
V
G
-
L
D
F
D
S
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
------
K
G
K
K
V
-----------------------------
69
PsiBlast_CBE
56.55
32%
-114
- C3 -
4HLU
3
ECFA2_THEMA
B:
[23-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
---------------------
P
T
S
G
D
V
L
Y
---------
D
----------
G
E
R
K
KGY
E
I
--------
R
R
N
I
G
I
-------------------------------------------------------------------------
A
F
Q
Y
P
EDQF------
F
A
E
--------------------------------------------------
R
V
F
D
-
E
V
--
A
F
A
V
---------------------
K
N
F
------------
Y
P
D
R
D
P
-
V
P
L
V
K
-----
K
A
M
E
F
V
G
-
L
D
F
D
S
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
------
K
G
K
K
V
-----------------------------
41
PsiBlast_CBE
54.52
33%
-94
- C3 -
4YMV
1
?
A:
[13-239]
-------------------
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-----
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
----
K
V
R
Q
K
-
V
--
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
-
K
K
------
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
---
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
--
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
-
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
------
D
D
G
V
I
V
E
E
-
G
T
P
E
E
I
F
Y
--
R
A
K
N
E
R
-
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
52.69
32%
-113
- C3 -
4ZIR
5
ECFA2_THEMA
A:
[22-218]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
---------------------
P
T
S
G
D
V
L
Y
---------
D
----------
G
E
--KGY
E
I
--------
R
R
N
I
G
I
-------------------------------------------------------------------------
A
F
Q
Y
P
EDQF------
F
A
E
--------------------------------------------------
R
V
F
D
-
E
V
--
A
F
A
V
---------------------
K
N
F
------------
Y
P
D
R
D
P
-
V
P
L
V
K
-----
K
A
M
E
F
V
G
-
L
D
F
D
S
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
------
K
G
K
K
V
-----------------------------
58
PsiBlast_CBE
50.44
34%
-99
- C3 -
4S0F
2
?
A:
[505-711]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
---------------------
P
E
K
G
D
I
L
I
N
G
H
S
I
---
K
N
----------
I
S
L
E
---
L
I
--------
R
K
K
I
A
F
-------------------------------------------------------------------------
V
S
Q
D
V
----------
F
I
----------------------------------------------------
F
S
G
-
T
V
K
E
N
L
C
L
---------------------
G
N
E
------------
N
V
D
M
D
E
I
I
K
A
A
K
M
A
NA
H
D
F
I
E
K
L
P
-
L
K
Y
D
T
F
-
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
---
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
--
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
------
D
G
E
I
V
E
S
G
S
H
T
E
L
I
--------------------
57
PsiBlast_CBE
49.89
34%
-95
- C3 -
4S0F
2
?
B:
[505-711]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
---------------------
P
E
K
G
D
I
L
I
N
G
H
S
I
---
K
N
----------
I
S
L
E
---
L
I
--------
R
K
K
I
A
F
-------------------------------------------------------------------------
V
S
Q
D
V
----------
F
I
----------------------------------------------------
F
S
G
-
T
V
K
E
N
L
C
L
---------------------
G
N
E
------------
N
V
D
M
D
E
I
I
K
A
A
K
MANAH
D
F
I
E
K
L
P
-
L
K
Y
D
T
F
-
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
---
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
--
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
------
D
G
E
I
V
E
S
G
S
H
T
E
L
I
--------------------
62
PsiBlast_CBE
43.06
31%
-85
- C3 -
2FF7
1
A:
[25-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
---------------------
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
------
W
L
--------
R
R
Q
V
G
V
-------------------------------------------------------------------------
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
-------------------------------------------
A
--
N
P
G
M
S
V
------
E
K
V
I
Y
---------------------
A
A
K
------------
L
A
G
A
H
D
F
I
S
E
L
R
-----
E
G
Y
N
T
I
V
-
G
E
-
Q
G
A
-------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
---
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
------
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
------------
61
PsiBlast_CBE
42.93
31%
-89
- C3 -
2PMK
1
A:
[21-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
---------------------
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
------
W
L
--------
R
R
Q
V
G
V
-------------------------------------------------------------------------
V
L
Q
D
N
VLLNRS
I
I
D
N
I
S
L
-------------------------------------------
A
--
N
P
G
M
S
V
------
E
K
V
I
Y
---------------------
A
A
K
------------
L
A
G
A
H
D
F
I
S
E
L
R
-----
E
G
Y
N
T
I
V
-
G
E
-
Q
G
A
-------
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
---
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
------
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
------------