@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0202: (2016-03-13 )
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFDARETAPEHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHAANWATEKYSRQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIILEDLANYDIQIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHVDLPSMGPRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQSLIDDDYLKARSTLINSNKANIDIEHGVVSDCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVDGGINEIAPYKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAIDEPRIYSSHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDLNTRDASGGADDTREGTVIGGDVLSIRKQPLPSPKIYDNDTHRVYFNDMQLPLYAEQVRWMHDKYWVDESVIRIIFPEVSVHIEDLRSYEIAGKNYIDIAWLARKKGYQVTLKDDSLYLTDETYHSVKANTNAYYRYDRDSITR
Atome Classification :
(29 SA)
.........10......-..20........30........40........50........60....-....70........80..-......90-........100......-.110...--....120.......130.-......140.......150.......160.......170------.-.---.-....-180..-......190.......200........210.......220-.......230.......240.......250.....-..260.......270.......-280.......290-..-.....300.......310.......320.......330.......340.........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510........520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.--.....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
I
NLNDKQTKTSKE
G
L
-
I
SVS
H
P
L
A
A
K
I
G
K
D
V
L
DQGGN
A
M
D
A
V
I
A
I
Q
L
A
L
N
V
V
E
P
F
ASGIGGG
G
Y
-
L
L
Y
Y
EQSTG
S
I
T
A
FDARE-T
A
P
E
HVD
K
-
Q
F
YLDDSGEY
K
S
F
F
D
MT-THG
K
T
V
A--V
P
A
I
P
K
L
F
D
Y
I
H
K
R
Y
A
K
L
-
S
L
E
D
LIN
P
A
I
E
L
A
IEGHAANW
A
T
E
K
Y
S
R
Q
Q
H
A
R
L
T
K
Y
H
E
------
T
-
A
---
Q
-
V
FTH-EN-QY-WREG
D
W
I
VQPEL
G
K
T
F
Q
-
I
L
R
E
QGFN
A
F
Y
K
G
D
I
A
K
Q
L
V
N
V
-
V
K
ACG
G
T
I
I
L
E
DLANY
D
I
Q
I
KAPIS
A
T
F
KDY
D
I
Y
S-MGPSSSG
G
I
T
V
I
Q
I
L
K
L
L
E
HVD-LPSMGP
R
S
V
D
Y
L
H
-
H
L
-
I
Q
A
M
H
L
A
Y
S
D
R
A
Q
Y
LADDNFHEV
P
V
Q
S
LI
D
D
D
Y
L
K
A
R
S
T
L
INSNKA--
N
I
D
I
EH
G
V
V
S
D
C
I
SHTDVEENHTET
T
H
F
C
V
IDKEG
N
I
A
S
F
T
T
S
I
G
M
I
YGS
G
I
T
IPG
Y
G
V
L
L
NTTMDGFDVVDG
G
I
N
EIAPYKR
P
L
S
NMA
P
T
I
V
M
HHG
K
P
I
L
T
VGAP
G
A
I
S
I
I
A
S
V
A
Q
T
L
I
N
V
L
V
FG
M
D
I
Q
Q
AIDEPRIYSSHPN
R
I
EWEPQFSQ
S
T
I
L
A
L
I
ARGHAMEHKP-DAYIGDVH
G
L
Q
V
D
LNTRDASGGADDTRE
G
T
V
IGG
D
V
L
S
I
RKQPLPSPKIYDNDT
H
R
V
Y
F
NDMQL
P
L
Y
A
E
Q
V
R
W
M
H
D
KYWV
D
E
S
V
I
R
I
IFPE
V
S
V
H
I
E
D
L
RSYEIAGK
N
Y
I
D
I
A
W
L
ARKKG
Y
Q
V
T
LKDD
S
L
Y
L
TDE
T
Y
H
S
VKANT
N
A
Y
Y
R
Y
D
R
--DSITR---
52
HHSearch
99.10
27%
-78
* C3 *
2NLZ
-
?
A:
[15-539]
------
R
R
N
V
V
Y
A
K
N
G
M
-
V
A
T
S
Q
P
L
A
A
Q
A
G
L
D
I
L
K
A
G
G
N
A
I
D
A
A
I
A
T
A
T
A
L
T
V
L
E
P
T
S
N
G
I
G
S
D
A
F
-
A
L
V
W
T
K
G
--
K
L
H
G
L
N
G
S
G
-
R
A
P
M
S
L
T
M
-
E
A
V
K
A
-
K
G
---
Y
E
Q
E
L
P
P
Y
G
V
I
P
V
T
--
V
P
G
A
P
G
A
W
A
E
L
A
K
M
Y
G
N
L
-
P
L
A
A
S
L
A
P
A
I
R
Y
A
E
E
G
Y
P
V
T
P
T
L
A
K
Y
W
K
A
A
Y
D
R
---
V
K
T
EWTDDV
Y
Q
P
W
F
-
D
-
T
F
A
P
K
G
R
--
A
-
P
R
V
G
E
V
W
R
S
Q
G
H
A
D
T
L
R
-
S
I
A
E
S
N
G
E
S
F
Y
R
G
E
L
A
D
Q
I
H
A
F
-
F
D
K
H
G
G
Y
L
T
K
E
D
L
A
C
Y
R
P
E
W
V
E
P
I
S
I
D
Y
R
G
Y
R
V
W
E
-
I
P
P
N
G
-
Q
G
L
V
A
L
E
A
L
N
I
V
K
G
F
E
-
F
Y
H
K
--
D
T
V
D
T
Y
H
-
K
Q
-
I
E
A
M
K
L
A
F
V
D
G
M
K
Y
V
T
E
P
S
D
M
S
V
S
V
E
Q
L
L
S
D
E
Y
A
T
E
R
R
K
E
I
G
E
Q
A
L
----
T
-------
P
E
----
P
G
T
P
----
T
V
Y
L
A
T
A
D
G
D
G
N
M
V
S
F
I
Q
S
N
Y
M
G
F
G
S
G
V
V
V
P
G
T
G
I
A
M
Q
N
R
G
H
N
F
S
L
D
P
N
H
D
N
A
L
K
P
G
K
R
T
Y
H
T
I
I
P
G
F
L
T
K
N
D
Q
P
I
G
P
F
G
V
M
G
G
F
M
Q
P
Q
G
H
M
Q
V
M
M
N
T
I
D
F
G
L
N
P
Q
A
A
L
D
A
P
R
W
Q
W
T
N
G
K
Q
V
Q
V
E
P
T
F
P
V
D
I
A
Q
A
L
V
R
R
G
H
K
I
Q
V
V
L
D
E
G
A
F
G
R
G
Q
I
I
W
R
D
P
T
T
G
V
L
A
G
G
T
E
P
R
T
D
G
Q
V
A
A
W
--------------------------------------------------------------------------------------------------------------------------------
69
Fugue
88.52
26%
-61
- C3 -
2I3O
-
?
D:
[2-516]
----
F
R
S
R
P
N
A
L
S
Q
R
S
V
-
I
A
S
S
S
E
L
A
S
L
A
G
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
A
V
S
-
A
L
C
V
T
Q
N
N
L
C
G
L
G
G
D
L
F
-
A
L
I
R
D
E
N
-
G
Q
I
-
D
L
N
G
S
G
-
Q
A
S
R
A
V
S
I
-
D
Y
Y
E
S
G
L
T
K
------
I
P
-
E
R
G
P
Y
A
A
IT
V
P
G
I
A
G
S
W
D
E
I
F
R
K
F
A
T
--
D
I
A
D
I
L
E
P
A
I
R
T
A
S
A
G
F
P
I
T
Q
N
Y
S
D
S
I
A
R
S
A
P
V
I
G
Q
Y
R
G
------
W
-
S
---
S
-
I
F
P
N
--
G
-
S
V
-
P
V
A
G
E
I
L
K
Q
P
D
L
A
E
S
F
R
--
L
S
E
E
G
F
R
S
F
Y
D
G
S
L
A
D
I
I
I
A
G
-
L
E
G
T
G
S
P
L
S
D
R
D
L
R
V
Y
R
P
L
I
G
K
P
V
F
T
D
L
D
E
F
R
I
Y
E
-
T
S
P
N
S
Q
G
-
I
T
V
I
E
W
I
R
G
E
S
H
-----
G
Y
D
S
R
T
W
E
A
K
I
-
E
D
-
I
F
E
T
E
E
A
Y
D
K
R
R
K
I
T
--
D
P
S
Y
N
I
A
Q
H
D
S
A
N
G
K
G
L
P
K
R
D
------------------------
H
N
D
I
G
----
D
T
T
Y
F
S
I
S
D
S
E
G
R
S
V
S
I
I
Q
S
N
-
Y
G
F
G
S
G
I
V
P
K
G
T
G
F
V
L
Q
N
R
G
S
Y
F
T
L
Q
R
D
H
P
N
A
L
-
P
G
K
R
T
F
H
T
L
A
A
C
V
E
K
E
H
-
D
L
Y
A
S
L
G
S
G
G
D
I
Q
P
Q
V
---
Q
Q
I
L
E
I
L
K
D
N
T
D
P
Q
A
I
L
D
K
P
R
W
T
---------
E
P
--------------------------------------------------------------------
Y
T
I
Y
E
A
P
G
--------------------------------------
A
V
Y
V
E
S
E
E
L
Y
R
N
V
S
K
Q
I
---------
S
G
R
K
V
V
L
R
D
V
S
Q
E
F
G
T
A
Q
I
T
T
L
I
R
G
D
V
V
V
G
A
A
D
P
RG
D
G
I
A
I
PYS
6
PsiBlast_PDB
85.96
39%
-86
- C3 -
3WHS
1
GGT_BACSU
A:
[55-393]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
K
K
P
K
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.66
39%
-82
- C3 -
3WHR
-
?
A:
[55-393]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
K
K
P
K
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.49
39%
-81
- C3 -
3A75
1
?
C:
[21-353]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.35
39%
-84
- C3 -
3WHQ
-
GGT_BACSU
A:
[55-393]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
K
K
P
K
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.33
39%
-82
- C3 -
3A75
1
?
A:
[21-353]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.79
38%
-81
- C3 -
2V36
-
GGT_BACSU
A:
[39-377]
-------
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
E
N
G
K
A
I
P
F
S
E
R
V
-
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
L
S
R
-
T
A
------
A
-
K
---
D
-
V
F
L
P
-
N
G
-
E
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
P
K
I
L
D
H
F
N
-
L
S
--
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
--
N
K
K
P
K
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
84.64
40%
-85
- C3 -
3WHR
-
?
A:
[54-386]
------
Y
K
Q
V
D
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
-
R
A
P
A
G
A
T
P
-
D
M
F
L
D
-
E
N
G
K
A
I
P
F
S
E
R
V
T
K
G
T
A
V
G
--
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
-
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
E
K
---
L
S
R
------
T
-
A
AK-
D
-
V
F
L
P
N
G
E
--
P
-
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
-
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
-
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
-
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
-
L
S
Q
Y
D
V
R
S
W
E
K
Y
Q
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.33
38%
-85
- C3 -
4OTU
1
?
A:
[36-373]
--------
K
V
A
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
-
R
A
P
E
G
A
K
P
-
D
M
F
L
D
E
D
G
K
V
I
P
F
S
E
R
S
-
R
H
G
N
A
V
G
--
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
-
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
D
K
L
S
K
T
A
-------
A
-
K
---
D
-
I
F
L
P
-
D
G
-
E
P
-
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
-
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
-
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
-
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
-
L
S
Q
Y
D
P
K
S
F
E
K
Y
H
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
--
N
R
D
V
K
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.45
38%
-86
- C3 -
4OTT
1
?
A:
[36-373]
--------
K
V
A
V
G
K
D
G
M
-
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
-
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
-
R
A
P
E
G
A
K
P
-
D
M
F
L
D
E
D
G
K
V
I
P
F
S
E
R
S
-
R
H
G
N
A
V
G
--
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
-
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
D
K
L
S
K
T
A
-------
A
-
K
---
D
-
I
F
L
P
-
D
G
-
E
P
-
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
-
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
-
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
-
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
-
L
S
Q
Y
D
P
K
S
F
E
K
Y
H
-
L
L
-
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
--
N
R
D
V
K
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.83
37%
-86
- C3 -
2QM6
1
?
A:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
81.55
37%
-83
- C3 -
2QM6
1
?
C:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.28
35%
-80
- C3 -
2Z8K
1
GGT_ECOLI
C:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.28
37%
-84
- C3 -
2QMC
1
?
A:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.26
37%
-85
- C3 -
3FNM
1
?
A:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.14
37%
-81
- C3 -
3FNM
1
?
C:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.03
37%
-84
- C3 -
2QMC
1
?
C:
[31-348]
----------
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
-
L
A
N
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
K
Q
G
N
V
--
V
P
K
L
S
-
E
D
G
Y
L
A
A
G-
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
F
L
K
Y
S
S
------
S
-
K
---
K
-
Y
F
F
K
-
K
G
-
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.02
35%
-80
- C3 -
2Z8I
1
?
C:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.88
35%
-79
- C3 -
2Z8J
1
?
C:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.62
35%
-81
- C3 -
2DBX
2
GGT_ECOLI
A:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.60
35%
-79
- C3 -
2DBW
2
?
A:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.54
35%
-80
- C3 -
2Z8K
1
GGT_ECOLI
A:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.28
35%
-79
- C3 -
2DG5
2
?
A:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.18
35%
-80
- C3 -
2Z8J
1
GGT_ECOLI
A:
[22-353]
------------
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
H
L
A
S
-
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
A
I
F
W
K
-
E
G
-
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
--
K
P
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
79.82
34%
-85
- C3 -
2DG5
2
?
A:
[16-348]
------
V
F
H
P
V
R
A
K
Q
G
M
-
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
-
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
-
M
A
P
A
K
A
T
R
-
D
M
F
L
D
-
D
Q
G
-
N
P
D
S
K
K
S
L
T
S
H
L
A
S
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
-
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
--
L
P
N
------
H
-
E
N
S
K
A
-
I
F
W
K
E
G
E
--
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
-
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
-
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
-
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
-
M
K
K
Y
G
F
G
S
A
D
A
M
Q
-
I
M
-
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
79.72
36%
-81
- C3 -
2QMC
1
?
A:
[30-359]
---------
I
K
N
T
K
V
G
L
-
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
-
A
V
I
H
L
A
N
-
G
E
N
V
A
L
D
F
R
E
-
K
A
P
L
K
A
T
K
-
N
M
F
L
D
-
K
Q
G
-
N
V
V
P
K
L
S
E
D
G
Y
L
A
A
G
--
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
-
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
E
R
---
F
L
K
------
Y
-
S
S
S
K
K
-
Y
F
F
K
K
G
H
-
L
D
-
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
-
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
-
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
-
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
-
L
S
A
L
G
Y
G
A
S
K
N
I
H
-
I
A
-
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
75.26
32%
-71
- C3 -
2DG5
2
?
A:
[13-363]
----
E
E
D
V
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
S
K
--
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
--
D
D
Q
G
N
P
D
S
K
K
S
L
T
-
S
-
H
L
A
S
G
--
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
-M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
L
P
N
H
E
------
N
-
S
---
K
-
A
I
F
W
-
K
E
G
E
P
-
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
-
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
-
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
M
P
-
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
---
Y
G
F
G
S
A
D
A
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
K
P
S
S
E
I
R
P
G
K
L
A
P
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.40
43%
-56
- C3 -
4OTU
2
?
B:
[1-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
F
G
T
G
I
L
V
P
G
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
G
G
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
E
E
P
R
I
Y
T
N
S
L
T
S
Y
R
Y
E
S
G
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
N
P
--
V
D
I
G
N
V
Q
S
I
F
I
D
R
E
N
K
T
F
M
G
V
A
D
S
S
R
N
G
T
A
V
G
V
N
I
------------------------------------------------------------------------------------------------------------------------------