@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0208: (2016-03-13 )
MTKRNPKLAALLSVIPGLGQFYNKRPIKGTIFFIFFISFISVFYSFLNIGFWGLFTLGTVPKLDDSRVLLAQGIISILLVAFAIMLYVINILDAYRNAERFNRNEEIKDPKARMVATWDKTFPYLLISPGTFLLIFVVVFPLIFMFGVAFTNYNLYNAPPRHTLEWVGLDNFKTLFTIGVWRKTFFSVITWTLVWTLVATTLQIALGLFLAIIVNHPVVKGKKFIRTVLILPWAVPSFVTILIFVALFNDEFGAINNDILQPLLGVAPAWLSDPFWAKVALIGIQVWLGFPFVFALFTGVLQSISSDWYEAADMDGASSWQKFRNITFPHVIYATAPLLIMQYAGNFNNFNLIYLFNKGGPPVSGQNAGSTDILISWVYNLTFEFNNFNMGAVVSLIIGFIVAIVAFIQFRRTSTFKDEGGL
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------.........10--.......-.20....--....30........40..---......50........60..-......70-.-------....------------...80........90.......-----.100..---..----...110.......120------........130...-----....140..-.....150.......160.......--170...----...-.180.......190.......200......----------.210....--..-------.220........230........240.......250..----...-..--260.......270....-....280.--------......-----290.......300.......310.--......320-----.......330......--------.340......-.---------------350.......360---------...-----.---.--..--..370.......380..---.....390------........400.....---..410.......420-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------MTKRN
P
K
L
A
A
L
--
L
S
VI
P
G
L
-
G
Q
F
Y
NKR--PIKG
T
I
F
F
I
F
F
I
S
F
I
S
V
F
---
Y
S
F
L
N
I
G
F
W
G
L
F
TLGTVPKL-DDS
R
V
L
L
A
-
Q
-------
G
I
I
S
------------
I
L
L
V
A
F
A
I
M
L
Y
V
I
N
I
L
D
A
Y
R
N
A
-----
E
RFNRN---EE----IKDPKA
R
M
V
A
T
WDKT-------
F
P
Y
L
L
ISP
G
T
F
L
L
I
-----
F
V
V
V
F
P
L
I
F
-
M
F
G
V
A
FTNYNLYNAPPR
H
T
L
E
W
VGL--DN
F
K
T
L
----
F
T
I
-
G
V
W
R
K
T
F
F
S
V
I
T
W
T
L
V
W
T
L
V
A
T
T
L
Q
I
A
L
G
L
----------
F
L
A
I
I
VNH--PV-------VK
G
-
K
K
F
I
R
T
V
L
I-LPWA
V
P
S
F
V
T
I
L
I
F
V
A
L
FNDEFGA----I
N
N
-
D
I
--
L
Q
P
L
L
GV
A
P
A
W-LSDP
F
-
W
A
K
V
A
L
I
G
--------
I
Q
V
W
L
G
-----
F
P
F
V
F
A
L
F
T
G
V
L
Q
S
I
S
S
D
W
Y
E
AAD--MDG
A
S
S
W
Q
K
-----
F
RNITF
P
H
V
I
Y
AT
A
P
L
--------
L
I
M
Q
YAGNFN-N---------------F
N
L
I
Y
L
FNKGG-----------PPV-----S---G--QN--AGST
D
I
L
I
S
W
V
Y
N
L
T
F
E
---FNNF
N
M
G
-------
A
V
V
S
L
I
I
G
F
I
V
A
I
V
A
F
---
I
Q
F
RRTSTFKDEGGL-----
7
PsiBlast_PDB
91.53
40%
-139
- C4 -
4JBW
1
MALF_ECOLI
F:
[245-509]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
---
V
N
L
K
A
T
--------------
2
PsiBlast_PDB
91.37
40%
-149
- C4 -
3PUY
2
MALF_ECOLI
F:
[245-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
6
PsiBlast_PDB
90.88
40%
-148
- C4 -
3RLF
2
MALF_ECOLI
F:
[245-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
8
PsiBlast_PDB
90.42
40%
-147
- C4 -
4KI0
5
MALF_ECOLI
F:
[245-505]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
---
V
N
------------------
1
PsiBlast_PDB
90.24
40%
-144
- C4 -
2R6G
1
MALF_ECOLI
F:
[245-504]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
---
V
-------------------
4
PsiBlast_PDB
89.81
40%
-148
- C4 -
3PUW
3
MALF_ECOLI
F:
[245-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
26
HHSearch
89.67
41%
-147
- C4 -
3RLF
2
MALF_ECOLI
F:
[256-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
T
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
-
M
L
--
S
A
-
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
TT
T
P
--
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
3
PsiBlast_PDB
89.54
40%
-149
- C4 -
3PUV
3
MALF_ECOLI
F:
[245-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
5
PsiBlast_PDB
89.09
40%
-149
- C4 -
3PUX
3
MALF_ECOLI
F:
[245-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
--
M
--
L
S
A
L
F
G
V
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
D
F
G
L
A
-------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------
35
Fugue
89.03
27%
-124
- C4 -
2R6G
1
MALF_ECOLI
F:
[13-504]
-----------------------------------DALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIA
I
A
F
T
N
Y
S
S
T
N
Q
--
L
T
F
E
R
A
Q
-
E
V
L
L
D
R
S
--
W
Q
A
G
K
T
Y
N
F
G
L
Y
P
A
G
D
E
W
---
Q
L
A
L
S
D
G
E
T
G
K
N
Y
L
S
D
A
F
K
F
-
G
G
E
Q
K
L
Q
L
-
K
-------
E
T
T
A
QPEGER------
A
N
L
R
V
I
T
Q
N
R
Q
A
L
S
D
I
T
A
I
L
P
D
-----
G
N
K
V
M
M
---
S
S
----
L
R
Q
F
S
G
T
Q
P
L
Y
T
L
D
G
-------
D
G
T
L
T
N
N
Q
S
G
V
K
Y
R
-----
P
N
N
Q
I
G
F
Y
Q
-
S
I
T
A
N
W
G
D
E
K
L
S
P
G
Y
T
----
V
T
T
G
W
--
K
N
F
T
R
V
----
F
T
D
-
E
G
I
Q
K
P
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
----------
V
L
A
C
L
V
Q
W
--
E
A
-------
L
R
G
-
K
A
V
Y
R
V
L
L
I
-
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
----
I
N
M
-
M
L
--
S
A
L
F
G
V
-
K
P
A
W
-
F
S
D
P
T
-
T
A
R
T
M
L
I
I
--------
V
N
T
W
L
G
-----
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
--
M
D
G
A
G
P
F
Q
N
-----
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
--------
M
I
A
S
F
A
F
N
F
N
-
N
---------------
F
V
L
I
Q
L
L
T
N
G
G
-----------
P
D
R
-----
L
---
G
--
T
T
TP
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
---
G
G
G
G
Q
D
F
-------
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
---
L
A
I
V
----------------
38
Fugue
74.04
18%
-141
- C4 -
4PW2
1
?
A:
[72-585]
-----------------------------------------------------------------------------------------------RY
E
E
I
D
C
L
I
ND
D
A
T
I
K
G
R
R
E
G
S
E
V
Y
M
P
--
F
S
W
M
E
K
Y
F
E
V
Y
G
K
V
V
--
Q
Y
D
G
Y
D
R
F
E
F
S
H
S
Y
S
K
V
Y
A
Q
R
E
Q
Y
H
P
N
G
V
F
M
S
F
E
G
Y
N
V
E
V
R
-
D
R
V
K
C
I
S
G
V
E
-------
G
V
P
L
S
TQWGPQ
G
Y
F
Y
A
I
Q
I
A
Q
Y
G
L
S
H
Y
S
K
N
L
T
E
R
P
P
H
V
-----
E
V
Y
D
T
A
---
E
E
RSA
W
T
V
P
K
G
C
S
L
T
R
V
Y
D
K
T
RA
T
S
V
R
E
F
S
A
P
E
N
S
E
G
V
S
L
P
L
GNTKD
F
I
I
S
F
D
L
K
F
T
S
N
G
S
V
S
V
I
L
E
T
T
E
K
G
P
P
F
V
I
H
Y
V
T
T
--
T
Q
L
I
L
L
K
DR
D
I
T
Y
-
G
I
G
P
R
T
-----
T
W
T
T
V
T
R
D
L
L
T
D
L
R
K
G
I
G
L
SNTKAVKATK
T
M
P
R
R
V
V
K
--
L
V
-------
V
H
G
-
T
G
T
I
D
N
I
T
I
S
T
T
S
H
M
A
A
F
Y
A
A
S
D
W
L
V
R
N
Q
D
E
R
G
G
WPIM
V
T
R
-
K
L
--
G
E
G
F
R
A
L
E
P
G
W
-
Y
S
A
M
A
-
Q
G
Q
A
M
S
T
L
--------
V
R
A
Y
L
M
TKDD
R
Y
L
K
A
A
L
R
A
T
G
P
F
K
L
P
S
E
Q
H
G
V
K
A
V
--
F
M
N
K
Y
D
W
Y
E
EYPTI
P
S
S
F
V
L
N
G
F
I
Y
S
L
I
G
L
--------
F
D
L
A
Q
T
A
G
E
K
-
L
G
R
D
A
G
Q
L
Y
S
K
G
M
E
S
L
K
V
M
L
P
L
Y
D
T
G
S
-----------
G
T
I
-----
Y
DL
R
H
--
F
I
--
L
G
T
A
P
N
L
A
R
W
D
Y
H
T
T
H
----
I
N
Q
L
Q
L
L
-------
G
T
I
D
N
S
P
I
F
R
D
S
V
K
R
W
---
K
S
Y
L
K
G
G
R
A
K
H
N
--------
9
PsiBlast_PDB
67.16
24%
-130
- C4 -
4TQU
-
?
M:
[54-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
G
F
--
D
H
F
V
T
L
----
F
Q
-----
S
E
Q
F
I
R
A
I
K
N
T
L
T
L
S
G
L
S
L
L
F
G
F
P
M
P
I
----------
L
L
A
L
M
I
N
E
--
V
Y
-------
S
K
G
Y
R
K
A
V
Q
T
I
V
Y
-
L
P
H
F
I
S
I
V
I
V
A
G
L
V
V
T
F
L
S
P
S
T
G
V
----
V
N
N
-----
M
L
S
W
I
G
L
D
R
V
Y
F
L
T
Q
P
E
-
W
F
R
P
I
Y
I
S
--------
S
N
I
W
K
E
-----
A
G
F
D
S
I
V
Y
L
A
A
I
M
S
I
N
P
A
L
Y
E
S
A
Q
--
V
D
G
A
T
R
W
Q
M
-----
I
T
R
I
T
L
P
C
I
V
P
T
I
A
V
L
--------
L
V
I
R
L
G
H
I
L
E
V
G
---------------
F
E
Y
I
I
L
L
Y
Q
--------------
P
T
-----
T
---
Y
--
E
T
--
A
---
D
V
I
S
T
Y
I
Y
R
L
G
L
Q
---
G
A
R
Y
D
I
A
TAAGIFN
A
V
V
A
L
V
I
--------------------------------
10
PsiBlast_PDB
66.61
24%
-128
- C4 -
4TQV
-
?
A:
[54-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
G
F
--
D
H
F
V
T
L
----
F
Q
-----
S
E
Q
F
I
R
A
I
K
N
T
L
T
L
S
G
L
S
L
L
F
G
F
P
M
P
I
----------
L
L
A
L
M
I
N
E
--
V
Y
-------
S
K
G
Y
R
K
A
V
Q
T
I
V
Y
-
L
P
H
F
I
S
I
V
I
V
A
G
L
V
V
T
F
L
S
P
S
T
G
V
----
V
N
N
-----
M
L
S
W
I
G
L
D
R
V
Y
F
L
T
Q
P
E
-
W
F
R
P
I
Y
I
S
--------
S
N
I
W
K
E
-----
A
G
F
D
S
I
V
Y
L
A
A
I
M
S
I
N
P
A
L
Y
E
S
A
Q
--
V
D
G
A
T
R
W
Q
M
-----
I
T
R
I
T
L
P
C
I
V
P
T
I
A
V
L
--------
L
V
I
R
L
G
H
I
L
E
V
G
---------------
F
E
Y
I
I
L
L
Y
Q
--------------
P
T
-----
T
---
Y
--
E
T
--
A
---
D
V
I
S
T
Y
I
Y
R
L
G
L
Q
---
G
A
R
Y
D
I
A
T
A
A
G
I
F
N
A
V
V
A
L
V
I
--------------------------------
28
HHSearch
64.17
15%
-153
- C4 -
3D31
-
?
C:
[44-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
V
L
F
-----
L
F
I
F
L
T
L
S
N
-
M
I
F
E
Q
I
T
E
---------------
D
F
--
S
G
L
V
K
A
----
A
G
N
-
R
----
S
V
I
S
S
I
F
L
S
L
Y
A
G
F
L
A
T
L
L
A
L
L
L
G
A
----------
P
T
G
Y
I
L
A
R
--
F
D
-------
F
P
G
-
K
R
L
V
E
S
I
I
D
-
V
P
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
F
G
S
-
R
G
L
----
I
G
E
-
P
L
--
E
--
S
---
Y
-----
I
Q
F
R
-
D
A
L
P
G
I
V
V
--------
A
M
L
F
V
S
-----
M
P
Y
L
A
N
S
A
R
E
G
F
K
S
V
D
P
R
L
E
N
A
A
R
--
S
L
G
A
P
L
W
K
A
-----
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
--------
S
V
M
T
W
A
R
A
I
S
-
E
---------------
F
G
A
V
V
I
L
A
Y
Y
----------------------------------
P
M
V
G
P
T
L
I
Y
D
R
F
I
S
----
Y
G
L
S
A
S
-------
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
L
---
V
I
R
-----------------
44
Fugue
63.25
16%
-140
- C3 -
3ES5
-
?
A:
[42-420]
---------------------------------------------------------------------------------------------------------------
M
R
L
G
W
I
D
P
L
P
Q
--
V
D
T
I
F
P
L
-
G
L
E
P
N
V
E
--
S
I
P
A
G
E
V
E
L
D
F
----
N
L
P
---
E
T
I
A
K
P
F
A
D
T
V
T
S
V
G
D
R
I
Q
L
V
D
D
D
K
E
N
I
A
-
T
-------
S
I
Y
G
------------
L
S
F
F
K
A
A
R
Q
L
Y
S
T
-
M
L
D
H
E
K
A
V
-----
N
--
Q
P
L
---
K
A
----
V
Y
Y
D
E
T
P
I
P
A
H
M
S
G
A
-------
L
G
I
I
G
H
M
K
T
K
V
G
D
V
-----
L
V
K
D
A
G
V
L
F
-
K
R
G
T
A
A
G
V
T
K
F
S
E
-----------
I
--
D
N
D
K
T
W
------------
N
L
D
C
S
K
L
V
W
A
D
H
S
S
L
S
M
I
K
R
L
A
S
E
K
I
----------
S
Q
L
V
K
Q
R
Y
--
R
V
-------
T
D
A
-
Q
G
H
V
Y
S
V
S
M
-
P
Q
L
T
D
Q
A
L
P
D
Y
Y
D
S
I
P
D
V
-----
A
----
P
N
S
-
D
Q
--
L
R
V
L
T
A
A
L
Q
---
M
S
L
A
Q
-
F
R
N
D
E
L
P
-------------------------------
H
D
E
D
R
S
D
L
L
T
T
L
D
--
L
L
Y
A
D
G
A
Y
E
-----------
I
S
A
L
R
D
Q
F
E
L
--------
L
M
A
R
Y
T
T
D
F
--
K
---------------
W
R
V
E
S
I
F
K
V
G
P
-----------
P
P
A
GTTGY
G
---
A
--
Q
T
--
V
S
S
T
G
N
T
A
R
W
Q
F
P
L
S
D
A
---
D
I
N
I
G
Y
L
-------
F
S
P
S
K
S
F
S
L
F
P
K
M
V
G
Y
S
KR
A
R
E
D
A
S
A
S
F
A
N
S
D
A
K
KFYAD
36
Fugue
63.06
15%
-148
- C4 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
L
F
S
A
-
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
--
F
N
F
D
E
F
----
L
K
A
-
A
S
-
D
P
A
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
----------
P
L
A
Y
I
L
A
R
--
K
S
-------
F
P
G
-
K
S
V
V
E
G
I
V
D
-
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
S
--------------------
G
L
I
G
S
F
-
S
P
L
K
F
V
D
A
L
P
G
I
V
V
--------
A
M
L
F
V
S
-----
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
--
T
L
G
S
S
P
L
R
V
-----
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
--------
A
I
M
S
W
A
R
G
I
S
-
E
---------------
F
G
A
V
V
V
I
----------------------------------
A
Y
Y
P
M
I
A
P
T
L
I
Y
E
R
Y
L
S
---
E
G
L
S
A
A
M
-------
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
---
L
R
I
I
V
G
--------------
27
HHSearch
62.91
15%
-155
- C4 -
2ONK
-
WTPB_ARCFU
C:
[28-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
L
L
A
L
L
S
S
I
I
L
-----
L
F
V
L
L
P
V
A
A
-
T
V
T
L
Q
L
F
----------------
N
F
--
D
E
F
L
K
A
----
A
S
D
-
P
----
A
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
----------
P
L
A
Y
I
L
A
R
--
K
S
-------
F
P
G
-
K
S
V
V
E
G
I
V
D
-
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
L
----
I
G
S
-
F
S
--
P
-------
L
K
F
-----
V
-
D
A
L
P
G
I
V
V
--------
A
M
L
F
V
S
-----
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
--
T
L
G
S
S
P
L
R
V
-----
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
--------
A
I
M
S
W
A
R
G
I
S
-
E
---------------
F
G
A
V
V
V
I
A
Y
-
Y
---------------------------------
P
M
I
A
P
T
L
I
Y
E
R
Y
L
S
----
E
G
L
S
A
A
-------
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
---
A
L
R
I
I
V
G
-------------
42
Fugue
60.33
12%
-124
- C1 -
4BHW
5
EP300_HUMAN
A:
[14-576]
K
K
I
F
K
P
E
E
L
R
Q
A
L
M
P
T
L
E
A
L
Y
R
QDPESLPFRQPVDPQLLGIPDYFDIVK
S
P
M
D
L
S
T
I
K
R
K
L
D
T
GQYQE
P
W
Q
Y
V
D
D
I
W
L
M
F
N
N
A
W
L
Y
NRKTS
R
V
Y
K
Y
C
S
K
L
S
E
V
F
E
Q
E
I
D
P
V
M
Q
S
L
G
Y
C
C
G
R
K
--
L
E
F
S
P
Q
T
-
L
C
C
Y
G
K
Q
L
C
T
I
P
R
D
A
T
Y
Y
S
Y
Q
N
R
Y
H
F
C
---
E
K
C
F
N
E
I
Q
G
E
S
V
S
L
G
D
D
P
S
Q
-
P
Q
T
T
I
N
K
E
-
Q
FSKRKN
D
T
L
D
P
------------
E
L
F
V
E
C
T
E
C
G
R
K
M
H
Q
I
C
V
L
H
H
E
-----
I
I
W
P
A
G
FVC
D
G
----
C
L
K
K
S
A
R
T
R
K
E
N
K
F
S
-------
A
K
R
L
---
P
S
T
R
L
G
T
-----
F
L
E
N
R
V
N
D
F
-
L
R
R
Q
N
H
P
E
S
G
E
V
T
V
R
V
V
H
A
S
D
K
T
V
E
V
K
P
G
M
K
A
R
----
F
V
D
S
G
E
M
A
E
S
F
P
Y
R
T
K
A
L
F
A
F
E
E
I
D
G
V
D
L
C
F
F
G
M
----------
H
V
Q
E
Y
G
S
D
CP
P
P
-------
N
Q
R
-
R
V
Y
I
S
Y
L
D
S
-
V
H
F
F
R
P
K
C
L
R
T
A
V
Y
H
E
I
L
I
G
Y
L
E
Y
----
V
K
K
L
G
Y
--
T
T
G
H
I
W
A
C
P
P
S
-
E
G
D
D
Y
-
I
F
H
C
H
P
P
D
Q
K
I
P
K
P
K
R
L
Q
E
W
F
K
-----
K
M
L
D
K
A
V
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
T
E
D
R
L
T
S
A
K
E
L
P
Y
-----
F
E
G
D
F
W
P
N
V
L
E
E
S
I
K
E
S
GGSGSQK
L
Y
A
T
M
E
K
H
K
E
-
V
---------------
F
F
V
I
R
L
I
A
G
P
A
ANSL
P
P
I
V
D
PD
P
L
I
-----
P
---
C
--
D
L
--
M
D
G
R
D
A
F
L
T
L
A
R
D
K
H
L
E
---
F
S
---------------
S
L
R
R
A
Q
W
S
T
M
C
M
L
---
V
E
L
H
T
Q
S
Q
D
-----------
29
HHSearch
59.00
14%
-154
- C4 -
3TUI
-
METI_ECOLI
A:
[7-215]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
L
V
R
G
V
W
E
T
L
A
M
T
F
V
S
G
F
F
G
F
V
I
G
L
----------
P
V
G
V
L
L
Y
V
--
T
R
PGQIIAN
A
K
L
-
Y
R
T
V
S
A
I
V
N
-
I
F
R
S
I
P
F
I
I
L
L
V
W
M
I
P
F
T
R
V
I
V
G
T
----------------------------
S
-
I
G
L
Q
A
A
I
V
--------
P
L
T
V
G
A
-----
A
P
F
I
A
R
M
V
E
N
A
L
L
E
I
P
T
G
L
I
E
A
S
R
--
A
M
G
A
T
P
M
Q
I
-----
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
--------
A
T
I
T
L
I
T
L
V
G
-
Y
---------------
S
A
M
G
G
A
V
G
------------------------------------
A
G
G
L
G
Q
I
G
Y
Q
Y
G
Y
I
---
G
Y
N
A
T
V
M
-------
N
T
V
L
V
L
L
V
I
L
V
Y
L
I
Q
F
---
A
G
D
R
I
V
R
A
V
T
----------
41
Fugue
58.97
19%
-145
- C2 -
4TXD
1
?
A:
[21-369]
------------------------------------------------------------------------------------------------------------------
K
R
D
V
L
A
E
L
GL
G
D
L
R
P
Y
L
-
R
S
I
G
D
K
D
--
R
I
F
P
K
A
H
R
I
E
V
V
F
L
V
R
A
----
A
N
Y
L
L
L
R
T
E
G
A
G
T
I
-
N
M
T
T
L
-
E
Y
S
G
G
A
M
E
-
V
-------
P
V
I
Q
------------
P
Q
K
L
M
A
V
T
R
R
Q
M
L
Q
L
L
R
E
Y
R
D
S
LD
E
V
S
K
R
W
L
V
Q
---
E
V
----
I
G
K
A
K
D
L
G
F
K
K
V
S
E
E
-------
W
N
C
T
I
Q
G
M
D
G
F
C
------------
P
H
C
T
-
I
F
G
A
A
L
T
--------
E
Q
H
N
E
K
F
G
G
L
--
S
-----------
I
-
G
I
K
T
R
V
R
F
D
--------
P
A
F
A
T
Q
R
R
I
T
P
E
T
----------
H
N
K
V
T
E
G
H
--
L
S
-------
M
T
G
-
Q
A
L
F
S
E
V
H
V
-
E
P
G
T
V
--
F
I
G
R
A
E
L
V
D
L
T
E
P
E
L
V
A
----
T
L
Y
-
S
L
A
T
L
R
E
L
G
G
R
S
G
I
Y
-
G
-----
T
V
R
V
E
I
L
G
--------
V
K
A
G
-------------------
K
Y
A
S
T
T
A
Y
D
L
A
A
--
E
N
A
G
K
G
Y
E
E
-----
V
K
K
N
L
K
E
R
L
E
K
L
------------------------------------------------
G
F
-----------
T
P
V
-----
D
---
N
--
S
K
--
L
L
A
A
---------
V
D
H
K
---
D
P
N
G
L
F
K
-------
D
L
W
R
S
S
I
D
F
A
E
K
M
V
K
W
---
V
E
E
L
K
-------
G
G
G
-----