@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0210: (2016-03-13 )
MMTIKVGIIGCGGIANGKHMPSLQKVENVEMIAFCDVDISKAASAAEAYGTDNAKVYDDYKALLKDDTIDVIHVCTPNDSHCEITVAGLHAGKHVMCEKPMAKTTAEAQKMIDTAKSTGKKLTIGYQNRFRPDSQFLHQAAQRGDLGDIYFGKAHAIRRRAVPTWGVFLNEEAQGGGPLIDIGTHALDLTLWMMDNYEPESVMGSTFHKLNKQHDAANAWGSWNPDEFTVEDSAFGFIKMKNGATIILESAWAINSLEVDEAKCSLSGTKAGADMKDGLRIHGEDMGTLYTKHVELENKGVDFYEGNEVDEAEEEAKAWIDAVVNDTEPVVKPEQAMVVTKILEAIYQSAKSGKAIYFE
Atome Classification :
(22 SA)
----------------------------.........10.....--...20....-.-.--.---.30........40........---50.......--.60........70........80........90........100.......110......-.120........130....---...140.......150---.........--160---..---......170.......180.......190.......200.........210.......220.......230.......240.......250.......260.......270.....----.----.----280.-...-.--...290----...-..----...300-.-.-...--...310....-----------------...320..---....--.-330.-......340.......350.......---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------
M
M
T
I
K
V
G
I
I
GCGGIAN--GKHMP
S
L
Q
K
-V-E--N---
V
E
M
I
A
F
CDV
D
I
S
K
A
A
S
A
A
E
AY---GTDNA
K
V
Y
D
--
D
Y
K
A
L
LKDDTI
D
V
I
H
V
CTPNDS
H
C
E
I
T
V
A
GLHAGK
H
V
M
CEKP
M
A
K
T
T
A
E
A
Q
K
M
I
D
T
A
KST-G
K
-
K
L
T
IGYQNRFR
P
D
S
Q
F
---
L
H
Q
A
A
QRGDLG
D
I
Y-----FGK
A
H
A
I
R
R--RA----VP---T
W
G
V
F
LNEEAQGGG
P
L
I
D
IGT
H
A
L
D
L
T
L
W
M
MDNY
E
P
E
--
S
V
M
G
S
T
F
H
K
L
N
K
QHDAANAWGSWNPD
E
F
T
VEDS
A
F
G
F
I
K
MKN
G
A
T
I
I
L
ESAWAIN
S
L
E
VDE
A
K
CSLSGTKAGAD
M
K
D----
G
----
L
----
R
I
-H-GED-
M
--
G
T
L
Y
T
-----
K
H
V
-
E
L
----ENKGV--D-F-YEG--NEV
D
E
A
E
E
E
A
-----------------
K
A
W
I
D
A
V
V---NDTE--P-VVK
P
-
E
Q
A
M
V
V
T
K
I
L
E
A
I
Y
Q
SAKSG
K
A
I
YFE---------
2
PsiBlast_PDB
86.93
28%
-41
- C1 -
1OFG
1
GFO_ZYMMO
A:
[36-369]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
54
Fugue
86.88
25%
-53
- C1 -
1OFG
2
GFO_ZYMMO
A:
[1-381]
ATLP
A
G
A
S
Q
VPT
T
P
A
G
R
P
MPYAI
R
P
M
P
E
D
R
R
F
G
Y
A
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
-------
G
CQH
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
-
Y
GV
D
P
R
K
I
Y
D
Y
S
--
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
---
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
-----
M
V
T
T
D
N
S
D
V
M
D
Q
N
----
D
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
F
V
------------
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
S
H
G
A
S
S
Y
S
--
T
--
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
---
Q
-
F
-
I
M
P
--
A
N
-
N
Q
F
S
A
Q
L
-----------------
D
H
L
A
E
A
V
I
N
NK---
P
--
V
-
R
S
P
G
-
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
N
T
D
WG
Y
V
R
Q
GGY
3
PsiBlast_PDB
86.28
28%
-40
- C1 -
1RYD
4
GFO_ZYMMO
A:
[42-375]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
8
PsiBlast_PDB
86.26
28%
-41
- C1 -
1H6A
1
GFO_ZYMMO
A:
[88-421]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
5
PsiBlast_PDB
85.76
28%
-39
- C1 -
1H6D
2
GFO_ZYMMO
A:
[88-421]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
45
HHSearch
85.70
22%
-79
- C1 -
3EC7
5
IOLG_SALTY
A:
[22-348]
-----------------------------
M
T
L
K
A
G
I
V
G
I
G
M
I
G
S
---
D
H
L
R
R
L
A
N
T
V
-
S
--
G
---
V
E
V
V
A
V
C
D
I
V
A
G
R
A
Q
A
A
L
D
K
Y
---
A
I
E
-
A
K
D
Y
N
--
D
Y
H
D
L
I
N
D
K
D
V
E
V
V
I
I
T
A
S
N
E
A
H
A
D
V
A
V
A
A
L
N
A
N
K
Y
V
F
C
E
K
P
L
A
V
T
A
A
D
C
Q
R
V
I
E
A
E
Q
K
N
-
G
K
R
M
V
Q
I
G
F
M
R
R
Y
D
K
G
Y
V
Q
---
L
K
N
I
I
D
S
G
E
I
G
Q
P
L
-----
M
V
H
G
R
H
Y
N
A
--
S
T
----------
V
P
E
Y
-----
K
T
P
Q
A
I
Y
E
T
L
I
H
E
I
D
V
M
H
W
L
L
N
E
D
-
Y
K
--
T
V
K
V
Y
F
P
R
Q
S
--------------
S
L
V
T
T
L
R
D
P
Q
L
V
V
M
E
T
T
S
G
I
N
I
V
V
E
V
F
V
N
C
Q
Y
G
Y
--
D
I
H
C
D
V
T
G
E
K
G
M
A
E
L
P
T
----
V
----
A
----
S
A
-
A
-
V
R
K
-
A
--
A
K
Y
-
S
-----
T
D
I
-
L
V
----
D
--------
W
--
K
Q
--
R
F
I
D
A
Y
D
I
E
F
-----------------
Q
D
F
F
D
R
L
N
---
A
G
L
P
--
P
A
G
P
T
S
-
W
D
G
Y
L
A
A
V
T
A
D
A
C
V
K
S
Q
E
T
G
N
T
E
I
V
E
---------
7
PsiBlast_PDB
85.34
28%
-42
- C1 -
1H6B
2
GFO_ZYMMO
A:
[88-421]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
6
PsiBlast_PDB
85.17
28%
-40
- C1 -
1H6C
3
GFO_ZYMMO
A:
[88-421]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
-----
G
H
A
-
N
Q
----
S
M
M
P
Q
--
F
-
I
-
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
62
Fugue
83.83
23%
-50
- C1 -
2O4U
9
DHDH_MACFA
X:
[2-332]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
S
---
D
F
T
A
V
L
Q
T
-
L
-
P
--
R
SE-
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
---
D
I
P
--
K
A
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
-
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
---
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
-----
V
A
R
A
E
F
G
K
N
--
L
T
----
H
V
------
P
R
A
V
D
W
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
G
Q
K
P
E
--
K
I
S
V
M
G
R
R
H
-----------------
E
T
G
V
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
I
T
A
Q
L
----
S
N
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
----
P
----
C
-----
W
-
C
-
P
T
E
-
L
--
V
V
K
G
E
-----
H
K
E
-
F
L
----
L
P
P
V
P
--
K
-
N
-
C
N
F
--
D
N
G
A
G
M
S
Y
E
A
-----------------
K
H
V
R
E
C
L
R
---
K
G
L
K
ES
P
-
V
I
P
L
-
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
--
I
G
V
T
F
P
Q
D
---------
41
HHSearch
83.36
23%
-66
- C1 -
3KUX
1
?
A:
[5-349]
----------------------------
A
D
K
I
K
V
G
L
L
G
Y
G
Y
A
S
K
--
T
F
H
A
P
L
I
M
G
-
T
-
P
--
G
---
L
E
L
A
G
V
S
S
S
D
A
S
K
V
H
A
--
D
W
P
---
A
I
---
P
V
V
S
--
D
P
Q
M
L
F
N
D
P
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
-
G
L
-
L
L
S
V
F
H
N
R
R
W
D
S
D
F
L
T
---
L
K
T
L
L
A
E
G
S
L
G
N
V
V
-----
Y
F
E
S
H
F
D
R
Y
--
R
P
----
E
I
---
R
Q
R
W
R
E
Q
----
G
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
A
L
Q
L
F
G
L
--
P
E
--
T
L
N
V
D
L
G
M
L
R
---------------
P
G
S
Q
S
V
D
Y
F
H
A
V
L
S
Y
P
G
Q
R
-
V
V
L
H
S
T
V
L
A
A
A
E
---
T
A
R
Y
I
V
H
G
T
Q
G
S
Y
I
K
F
G
V
DP
Q
E
----
D
----
R
L
-
K
-
A
G
E
-
R
LP
Q
A
D
W
G
YDMR
D
G
I
V
-
T
L
----
S
H
D
N
V
L
T
E
-
K
-
P
L
L
--
T
L
P
G
N
Y
P
A
Y
Y
-----------------
A
G
I
R
D
A
I
W
---
G
T
A
P
--
N
-
P
V
P
A
-
T
E
A
I
K
V
M
E
L
I
E
L
G
I
A
S
D
Q
Q
K
K
A
L
P
I
I
---------
40
HHSearch
83.22
23%
-58
- C1 -
3OHS
10
DHDH_MACFA
X:
[2-332]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
S
---
D
F
T
A
V
L
Q
T
-
L
-
P
RS
E
---
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
---
D
I
P
--
K
A
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
-
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
---
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
-----
V
A
R
A
E
F
G
K
N
--
L
T
---------
H
V
P
R
A
V
D
W
-
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
G
Q
K
P
E
--
K
I
S
V
M
G
R
R
-----------------
H
E
T
G
V
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
H
G
S
F
T
C
S
I
T
A
Q
L
----
S
N
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
----
P
----
C
WCPT
E
L
-
V
-
V
K
G
-
E
--
H
K
---------
E
F
-
L
L
----
P
P
V
P
---
K
-
N
-
C
N
F
--
D
N
G
A
G
M
S
Y
E
A
-----------------
K
H
V
R
E
C
L
R
---
K
G
L
K
ES
P
-
V
I
P
L
-
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-----------
9
PsiBlast_PDB
83.00
25%
-63
- C1 -
3E18
10
?
A:
[10-349]
-----------------------------------
I
V
G
Y
G
G
M
G
S
---
Y
H
V
T
L
A
S
A
-
A
-
D
--
N
---
L
E
V
H
G
V
F
D
I
L
A
E
K
R
E
A
A
A
Q
-------
K
G
L
K
I
Y
E
--
S
Y
E
A
V
L
A
D
E
K
V
D
A
V
L
I
A
T
P
N
D
S
H
K
E
L
A
I
S
A
L
E
A
G
K
H
V
V
C
E
K
P
V
T
M
T
S
E
D
L
L
A
I
M
D
V
A
K
R
V
-
N
K
-
H
F
M
V
H
Q
N
R
R
W
D
E
D
F
L
I
---
I
K
E
M
F
E
Q
K
T
I
G
E
M
F
-----
H
L
E
S
R
V
H
G
A
--
N
G
----
I
P
-----
G
D
W
R
H
L
K
A
H
G
G
G
M
V
L
D
W
G
V
H
L
L
D
Q
L
L
F
L
V
D
S
----------------
N
V
K
S
V
S
A
N
L
S
F
A
L
G
-
D
E
--
V
D
D
G
F
V
T
F
I
T
F
E
N
G
I
T
A
Q
I
E
V
G
-
T
T
N
F
I
K
L
--
P
R
W
Y
V
K
G
T
E
G
T
G
------------------
I
I
-
H
-
D
W
D
-
L
--
S
G
E
I
V
-----
K
P
T
-
A
L
AKT
S
E
P
T
P
I
--
K
-
A
-
G
Q
G
LT
K
T
M
A
P
P
S
E
E
A
T
N
T
L
S
LPAPAKLAPS
F
Y
N
N
F
V
D
V
L
N
---
N
T
S
E
--
P
-
I
V
Q
N
-
E
E
V
Y
Q
V
L
K
L
I
E
A
I
F
E
A
A
E
T
N
R
T
V
H
-----------
4
PsiBlast_PDB
82.75
28%
-45
- C1 -
1RYE
4
GFO_ZYMMO
A:
[42-375]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
---------------------------
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
1
PsiBlast_PDB
82.58
28%
-44
- C1 -
1EVJ
1
GFO_ZYMMO
A:
[7-340]
-----------------------------------
I
V
G
L
G
K
Y
A
L
--
N
Q
I
L
P
G
F
A
G
-
C
-
Q
--
H
---
S
R
I
E
A
L
V
D
G
N
A
E
K
A
K
I
V
A
A
E
Y
---
G
V
D
P
R
K
I
Y
D
YS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
K
-
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
Q
L
G
K
L
G
M
V
T
-----
T
D
N
S
D
V
M
D
Q
--
N
D
-----
P
---
A
Q
Q
W
R
L
R
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E
-
E
P
I
--
E
V
R
A
Y
T
Y
S
D
P
N
D
E
R
------------
F
V
E
V
E
D
R
I
I
W
Q
M
R
F
R
S
G
A
L
----
S
H
G
A
S
S
Y
S
T
T
T
T
S
R
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
----
A
----
T
----
G
Y
-
Y
-
Q
N
L
-
I
--
S
V
Q
T
P
--------------------------
M
P
A
--
N
N
Q
F
S
A
Q
L
D
H
-----------------
L
A
--
E
A
V
I
---
N
N
-
K
--
P
-
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
------------
32
HHSearch
82.25
20%
-62
- C1 -
1ZH8
7
?
A:
[16-337]
----------------------------
L
R
K
I
R
L
G
I
V
G
C
G
I
A
A
R
--
E
L
H
L
P
A
L
K
N
-
L
-
S
H-
L
---
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
M
V
---
G
N
P
--
A
V
F
D
--
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
K
-
T
V
Y
I
A
E
N
F
R
H
V
P
A
F
W
K
---
A
K
E
L
V
E
S
G
A
I
G
D
P
V
-----
F
M
N
W
Q
I
W
V
G
--
M
D
ENNK
Y
V
---
H
T
D
W
R
K
K
-
P
K
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
E
I
--
E
--
W
I
S
A
V
A
K
D
L
S
---------------
P
L
L
G
G
M
D
F
L
S
S
I
F
E
F
E
N
G
T
V
G
N
Y
T
I
S
Y
S
L
K
G
----
N
E
R
F
E
I
T
G
T
K
G
K
I
S
I
S
W
----
D
---------
K
I
-
V
-
L
N
-----
E
---------
E
E
M
-
K
------------------
V
--
P
Q
E
N
S
Y
Q
K
E
F
-----------------
E
D
F
Y
Q
V
V
A
---
E
G
K
P
--
N
D
L
G
S
P
-
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
-----------
43
HHSearch
81.68
22%
-55
- C1 -
3EZY
2
?
A:
[2-331]
------------------------------
S
L
R
I
G
V
I
G
L
G
R
I
G
T
---
I
H
A
E
N
L
K
M
-
I
-
D
--
D
---
A
I
L
Y
A
I
S
D
V
R
E
D
R
L
R
E
M
K
E
K
L
---
G
V
E
--
K
A
Y
K
--
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
V
-
I
L
F
T
G
F
N
R
R
F
D
R
N
F
K
K
---
L
K
E
A
V
E
N
G
T
I
G
K
P
H
-----
V
L
R
I
T
S
R
D
P
--
A
------
P
----
P
P
L
D
Y
--
I
R
V
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
E
E
-
V
E
--
E
V
F
A
D
G
S
V
L
V
D
E
-----------
E
I
G
K
A
G
D
V
D
T
A
V
V
V
L
R
F
K
S
G
A
L
G
V
I
D
N
S
R
R
A
V
Y
G
--
Y
D
Q
R
I
E
V
F
G
S
K
G
R
I
F
A
D
N
----
V
----
R
ET--
T
V
V
L
-
T
D
E
-
Q
--
G
D
R
-
G
-----
S
R
Y
-
L
Y
-------------
F
-
F
L
E
--
R
Y
R
D
S
Y
L
E
E
L
-----------------
K
T
F
I
K
N
V
K
---
S
G
E
P
--
P
-
A
V
S
G
-
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
S
L
E
E
K
R
S
V
K
L
----------
47
HHSearch
81.65
23%
-60
- C1 -
3Q2I
4
?
A:
[11-351]
----------------------------
D
R
K
I
R
F
A
L
V
G
C
G
R
I
A
N
---
N
H
F
G
A
L
E
K
-
H
A
D
--
R
---
A
E
L
I
D
V
C
D
I
D
P
A
A
L
K
A
A
V
E
R
T
---
G
A
R
---
G
H
A
--
S
L
T
D
M
L
A
Q
T
D
A
D
I
V
I
L
T
T
P
S
G
L
H
P
T
Q
S
I
E
C
S
E
A
G
F
H
V
M
T
E
K
P
M
A
T
R
W
E
D
G
L
E
M
V
K
A
A
D
K
A
-
K
K
-
H
L
F
V
V
K
Q
N
R
R
N
A
T
L
Q
L
---
L
K
R
A
M
Q
E
K
R
F
G
R
I
Y
-----
M
V
N
V
N
V
F
W
T
--
R
P
----
Q
E
Y
Y
D
A
A
G
W
R
G
T
W
-
E
F
D
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
L
D
W
L
I
G
P
--
V
E
--
S
V
Q
A
Y
T
A
T
L
A
---------------
R
N
I
E
V
E
D
T
G
T
V
S
V
K
W
R
S
G
A
L
G
S
M
N
V
T
M
L
T
Y
P
K
-
N
L
E
G
S
I
T
I
L
G
E
K
G
S
V
R
V
G
G
----
V
AVNE
I
----
Q
H
-
W
-
E
F
S
-
E
--
P
H
A
M
D
-----
E
---
E
I
----
K
D
A
S
--------------
G
F
G
H
P
L
Y
Y
-----------------
D
N
V
I
K
T
M
R
---
G
E
A
T
--
P
-
E
T
D
G
-
R
E
G
L
K
S
L
E
L
L
I
A
M
Y
L
S
A
R
D
G
R
R
V
S
L
P
---------
48
HHSearch
81.19
22%
-58
- C1 -
3RC1
7
?
A:
[26-349]
-----------------------------
N
P
I
R
V
G
V
I
G
C
A
D
I
A
W
--
R
R
A
L
P
A
L
E
A
-
E
-
P
--
L
---
T
E
V
T
A
I
A
S
R
R
W
D
R
A
K
R
F
T
E
R
F
---
G
G
E
---
P
V
E
--
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
V
L
H
A
E
W
I
D
R
A
L
R
A
G
K
H
V
L
A
E
K
P
L
T
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
-
G
L
-
L
L
M
E
N
F
M
F
L
H
H
P
Q
H
R
Q
---
V
A
D
M
L
D
E
G
V
I
G
E
I
R
-----
S
F
A
A
S
F
T
I
P
--
P
-----
K
P
---
Q
G
D
I
R
Y
Q
-
A
D
V
G
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
A
G
L
F
L
G
A
D
-
L
E
--
F
V
G
A
V
L
R
H
E
----------------
R
D
R
D
V
V
V
G
G
N
A
L
L
T
T
R
Q
G
V
T
A
Q
L
T
F
G
M
E
H
A
Y
----
T
N
N
Y
E
F
R
G
S
T
G
R
L
W
M
N
R
----
V
----
F
----
T
P
-
P
-
A
-
T
-
Y
--
Q
P
V
-------
V
H
I
-
E
R
----
Q
D
H
A
E
--
Q
-
F
--
V
L
--
P
A
H
D
Q
F
A
K
S
I
-----------------
R
A
F
A
Q
A
V
L
---
S
G
E
H
--
P
-
R
E
W
S
-
E
D
S
L
R
Q
A
S
L
V
D
A
V
R
T
G
A
R
D
I
Y
F
-------------
36
HHSearch
80.97
19%
-61
* C1 *
3DB2
-
?
A:
[3-350]
----------------------------
Y
N
P
V
G
V
A
A
I
G
L
G
R
W
A
Y
---
V
M
A
D
A
Y
T
K
-
S
-
E
--
K
---
L
K
L
V
T
C
Y
S
R
T
E
D
K
R
E
K
F
G
K
R
Y
---
N
C
A
---
G
D
A
--
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
D
K
H
A
E
V
I
E
Q
C
A
R
S
G
K
H
I
Y
V
E
K
P
I
S
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
-
G
V
-
K
F
L
C
G
H
S
S
R
R
L
G
A
L
R
K
---
M
K
E
M
I
D
T
K
E
I
G
E
V
S
-----
S
I
E
A
V
F
S
N
E
--
R
G
LE--
L
K
---
K
G
N
W
R
G
E
P
A
T
A
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
N
L
Q
F
L
L
G
P
--
V
A
--
R
V
F
N
F
G
K
P
M
Y
---------------
T
E
V
E
N
I
T
V
N
Q
T
L
L
E
F
E
D
G
K
Q
A
Y
L
G
T
N
W
A
C
P
G
V
----
F
S
I
N
V
Y
G
T
K
A
N
L
F
Y
Q
L
----
D
----
F
----
S
W
-
W
S
N
S
D
V
T
--
D
E
H
S
T
L
I
K
--
R
E
F
A
S
-------
N
R
I
L
-
R
D
V
K
V
D
F
--
E
S
V
D
H
L
R
V
E
V
-----------------
E
E
V
A
D
V
I
R
---
N
G
G
E
--
T
-
E
I
G
A
-
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
P
V
E
I
A
---------
30
HHSearch
80.50
22%
-56
- C1 -
3CEA
1
?
A:
[6-345]
----------------------------
R
K
P
L
R
A
A
I
I
G
L
G
R
L
G
E
---
R
H
A
R
H
L
V
N
K
I
-
Q
--
G
---
V
K
L
V
A
A
C
A
L
D
S
N
Q
L
E
W
A
K
N
E
L
---
G
V
E
--
T
T
Y
T
--
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
Q
-
I
F
Q
S
G
F
M
R
R
Y
D
D
S
Y
R
Y
---
A
K
K
I
V
D
N
G
D
I
G
K
I
I
-----
Y
M
R
G
Y
G
I
D
P
--
I
S
G---
M
E
---
S
F
T
K
F
A
T
-
E
A
D
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
Q
-
D
P
V
--
Q
A
Y
G
L
T
S
N
I
A
A
--
P
---------
Q
L
A
D
I
G
E
F
E
T
G
V
A
Q
L
K
M
S
D
G
V
I
A
T
L
I
G
G
R
H
A
A
H
G
N
--
Q
V
E
L
E
V
M
G
S
N
G
W
V
R
I
G
E
----
H
PDL-
N
----
R
V
-
T
-
V
F
N
-
D
--
Q
G
V
-------
V
R
P
-
S
L
----
Q
S
---------
F
G
E
--
R
F
D
T
A
F
T
D
E
V
-----------------
Q
D
F
V
N
N
V
I
---
V
G
K
Q
--
P
-
E
V
T
V
-
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
S
A
N
I
G
K
L
V
D
I
Q
---------
13
PsiBlast_PDB
69.95
32%
-75
- C1 -
2POQ
6
DHDH_MACFA
X:
[2-201]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
S
DF
T
A
V
L
Q
T
L
P
R
-
S
-
E
--
H
----
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
-----
D
I
P
K
A
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
-
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
---
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
VARAE
F
G
K
N
L
T
H
V
P
--
R
A
----
V
----
D
W
-------
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
G
Q
K
P
E
KI
S
V
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.91
32%
-73
- C1 -
3OHS
9
DHDH_MACFA
X:
[2-201]
------------------------------
A
L
R
W
G
I
V
S
V
G
L
I
S
S
DF
T
A
V
L
Q
T
L
P
R
-
S
-
E
--
H
----
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
-----
D
I
P
K
A
Y
G
--
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
L
-
F
L
M
E
A
I
W
T
R
F
F
P
A
S
E
A
---
L
R
S
V
L
A
Q
G
T
L
G
D
L
R
VARAE
F
G
K
N
L
T
H
V
P
--
R
A
----
V
----
D
W
-------
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
G
Q
K
P
E
KI
S
V
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------