@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0223: (2016-03-13 )
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIRVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120....-----------.-----.--.130..-----..------.--.----.--..--------------140---..-......150........160.......170....--...180.......190.......200.......210.......220.......230...---------------------..--..-240.......250.......260.......270.......280.......290.......300.......310.......320.......330.--.---.--.....340.......350.......360......-.-370.......380-.......390..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
E
A
Y
I
V
A
YGRSAAAKAKQGALFHERP
D
D
V
A
A
K
V
L
Q
G
V
L
K
RIDGKF
N
K
N
M
I
E
D
V
I
VGTAFPEGLQG
Q
N
I
A
R
T
I
A
LRAGLSDTVP
G
Q
T
V
N
R
Y
C
SSG
L
Q
T
I
A
I
AANQIMAGQG
D
I
L
V
AG
G
V
E
L
M
S
AVP-----------M-----G--GN--EP-----TN------N--P----
T
--
L
Q
--------------YD----DI-GASYPMGL-
T
A
E
N
V
A
S
Q
FDVSRED
Q
D
A
Y
A
V
R
S
H
Q
--
R
A
YDAQRDGRFKD
E
I
I
P
I
R
V
N
S
V
E
YTNAGP
K
V
HTNIFD
Q
D
EFIRPD
T
T
M
E
A
L
A
K
L
R
T
V
F
---------------------KA--DG-
T
V
TAGTSAPLSDGA
G
F
V
V
L
MSGD
K
V
K
EL
G
V
T
P
I
A
R
F
VG
Y
K
AVGVDP
K
I
MGIG
P
A
Y
A
I
P
E
V
L
S
LSNLSVED
I
D
L
I
E
L
N
E
A
F
A
S
Q
T
I
A
S
I
K
E
VG-L--
D
---
I
--
S
RTNVNG
G
A
I
A
LGHPLGA
T
G
A
M
L
T
A
R
L
L
N
E
MGRR-P-DSRY
G
M
V
T
M
C
IGV-G
M
G
A
A
A
I
F
E
YVR
2
PsiBlast_PDB
95.29
46%
-85
- C3 -
2WU9
6
THIK2_ARATH
A:
[31-417]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
--
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
-----------
M
-----
A
--
W
E
--
G
S
-----
V
N
------
P
--
A
----
V
--
K
K
--------------
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
-
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
--
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
T
G
D
E
K
P
I
T
--
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---------------------
K
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
-
L
--
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
V
F
E
---
113
HHSearch
95.24
45%
-87
- C3 -
2WU9
7
THIK2_ARATH
A:
[29-419]
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
--
N
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
-----------
M
-----
A
--
W
E
G-
S
V
N----
P
A
------
V
--
K
----
K
---
F
--------------
A
Q
----
A
Q
-
N
C
L
L
P
M
G
V
-
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
--
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
--
P
K
T
G
D
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---------------------
K
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
-
L
--
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
-
G
K
D
C
R
F
G
V
V
-
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
R
G
-
21
PsiBlast_CBE
95.08
46%
-84
- C3 -
2WU9
3
THIK2_ARATH
B:
[31-417]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
--
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
-----------
M
-----
A
--
W
E
--
G
S
-----
V
N
------
P
--
A
----
V
--
K
K
--------------
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
-
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
--
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
T
G
D
E
K
P
I
T
--
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---------------------
K
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
-
L
--
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
V
F
E
---
1
PsiBlast_PDB
94.87
46%
-83
- C3 -
2WUA
-
?
A:
[49-435]
--
D
V
V
I
V
A
A
Y
R
S
P
L
C
K
A
K
R
G
G
L
K
D
T
Y
P
D
D
I
L
A
P
V
L
K
A
L
I
E
K
T
N
--
I
N
P
A
E
V
G
D
I
V
V
G
S
V
L
G
A
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
P
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
A
N
P
-----------
M
AWE--
G
--
S
V
--
N
P
-----
K
V
------
K
--
T
----
M
--
A
Q
--------------
A
Q
----
D
---
C
L
L
P
M
G
I
-
T
S
E
N
V
A
Q
K
F
S
I
T
R
Q
E
Q
D
Q
A
A
V
G
S
H
R
--
K
T
A
A
A
T
A
A
G
R
F
K
D
E
I
I
P
I
K
T
K
I
V
D
P
K
T
G
D
E
K
P
V
T
--
I
S
V
D
D
G
I
R
P
G
T
S
L
A
D
L
A
K
L
K
P
V
F
---------------------
R
K
--
D
G
-
S
T
T
A
G
T
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
I
A
L
Q
K
G
L
P
I
L
G
V
F
R
T
F
A
A
V
G
V
P
P
S
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
Q
I
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
Q
K
K
L
E
-
I
--
D
---
P
--
Q
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
R
-
D
C
R
F
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
V
F
E
---
3
PsiBlast_PDB
94.49
46%
-85
- C3 -
2C7Y
-
THIK2_ARATH
A:
[51-437]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
--
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
---------------------------------------------------
K
--------------
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
-
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
--
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
T
G
D
E
K
P
I
T
--
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---------------------
K
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
-
L
--
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
V
F
E
---
4
PsiBlast_PDB
94.46
46%
-85
- C3 -
2C7Z
-
THIK2_ARATH
A:
[51-437]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
T
N
--
L
N
P
S
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
-----------
M
-----
A
--
W
E
----------------------------
K
K
--------------
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
-
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
--
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
T
G
D
E
K
P
I
T
--
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
---------------------
K
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
-
L
--
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
V
F
E
---
118
HHSearch
93.42
46%
-85
- C3 -
1ULQ
-
?
A:
[3-399]
--
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
-
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
--
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
-----------
Y
-----
A
--
V
P
K
P
E
R
-----
G
F
P
-----
T
--
G
----
N
--
L
V
M
Y
DTTLGWRFVN
P
K
M
Q
----
A
L
-
Y
G
T
E
S
M
G
E
-
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
--
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
K
R
--------
G
K
E
E
I
L
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
---------------------
R
E
--
G
G
-
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
-
L
SM
E
---
D
--
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
---
K
V
Q
F
G
L
A
T
M
C
I
G
V
-
G
Q
G
I
A
V
V
V
E
G
--
123
HHSearch
92.73
42%
-87
* C3 *
2VU1
5
THIL_ZOORA
A:
[2-391]
T
P
S
I
V
I
A
S
A
A
R
T
A
V
G
S
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
--
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
-
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
-----------
H
-----
C
--
A
H
L-
R
G
GV---
K
M
------
G
D
F
K
MIDT
M
IK
D
G
--------------
L
T
----
D
A
-
F
Y
G
Y
H
M
G
T
-
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
--
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
--------
K
G
D
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
---------------------
D
K
--
E
G
-
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
-
W
--
D
---
P
--
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
---
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
E
S
--
114
HHSearch
92.72
44%
-84
- C3 -
3SS6
6
?
A:
[4-394]
M
H
N
V
V
I
T
A
A
V
R
S
P
I
G
T
F
-
G
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
A
V
K
R
G
--
G
V
E
P
H
E
V
D
E
V
I
L
G
H
C
I
Q
R
T
D
-
E
A
N
T
A
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
-----------
Y
-----
A
--
L
K
--
Q
H
-----
R
W
GQRLQH
G
--
E
----
I
--
R
D
T
-------------
V
W
E
V
LE
D
P
-
I
H
H
I
M
M
G
E
-
T
A
E
N
L
V
E
Q
Y
E
I
T
R
E
E
Q
D
E
V
A
L
R
S
H
T
--
L
A
L
K
A
I
E
S
G
Y
F
D
D
Q
I
V
P
I
T
I
K
E
R
--------
R
K
E
V
V
F
S
K
D
E
H
P
R
A
D
I
T
A
E
K
L
A
G
L
K
P
A
F
---------------------
R
K
--
D
G
-
S
V
T
A
G
N
A
S
G
L
N
D
G
S
A
V
L
V
L
M
S
E
E
K
A
K
E
K
G
L
Q
P
L
A
R
I
V
G
Y
S
V
A
G
V
D
P
K
I
M
G
I
G
P
A
P
A
I
R
K
G
L
E
K
V
D
W
S
L
E
D
A
D
L
L
E
I
N
E
A
F
A
A
Q
Y
L
A
V
E
K
E
L
D
-
L
--
D
---
R
--
E
K
V
N
V
N
G
S
G
V
G
L
G
H
P
I
G
C
T
G
A
R
I
T
V
S
L
I
H
E
L
K
R
R
---
G
L
E
K
G
I
A
S
L
C
V
G
G
-
G
I
G
V
A
L
F
I
E
A
L
-
121
HHSearch
92.69
43%
-86
- C3 -
3GOA
2
FADA_SALTY
A:
[1-386]
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
K
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
-
S
L
T
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
V
P
-----------
M
-----
S
--
H
G
---
V
-----
D
F
------
H
--
P
----
G
--
L
---------------
S
-----------
G
M
M
G
L
-
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
--
F
K
T
E
I
I
P
T
G
G
H
D
A
-------
D
G
V
L
K
Q
F
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
---------------------
D
P
V-
S
G
-
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
-
L
--
M
EQI
D
--
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
---
D
A
Q
F
G
L
A
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
--
72
PsiBlast_CBE
91.55
40%
-83
- C3 -
4O9C
1
THIL_CUPNH
C:
[1-391]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
-
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
--
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
HVLPGSRDGFR
M
-----
G
--
D
A
--
K
L
-----
V
D
--------------
T
--
M
I
--------------
V
D
GLW-
D
V
-
Y
N
Q
Y
H
M
G
I
-
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
--
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
-------
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
---------------------
D
K
--
A
G
-
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
-
W
--
D
---
T
--
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
---
D
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
---
6
PsiBlast_PDB
91.32
43%
-82
- C3 -
1WDK
2
FADA_PSEFR
C:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
-----------
M
M----
H
--
G
V
--
D
P
-------------
N
--
P
----
H
--
M
S
--------------
L
Y
----
A
A
-
K
A
S
G
M
M
G
L
-
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
--
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
----
G
Y
D
E
N
G
---
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
---------------------
N
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
--
D
---
K
MN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-
K
Q
-
N
-
G
G
T
F
G
L
S
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
V
-
55
PsiBlast_CBE
91.29
40%
-81
- C3 -
1M3Z
1
THIL_ZOORA
C:
[6-392]
-----
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
--
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
A
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
-----------
H
CAHLR
G
--
G
V
--
K
M
-----
G
D
------
F
--
K
----
M
--
I
D
TMIKDG--------
L
T
----
D
A
-
F
Y
G
Y
H
M
G
T
-
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
--
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
-------
G
R
K
G
D
I
T
V
-
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
---------------------
D
K
--
E
G
-
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
-
W
--
D
---
P
--
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
---
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
E
S
L
-
23
PsiBlast_CBE
91.24
43%
-80
- C3 -
1WDM
1
FADA_PSEFR
D:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
-----------
M
M----
H
--
G
V
--
D
P
-------------
N
--
P
----
H
--
M
S
--------------
L
Y
----
A
A
-
K
A
S
G
M
M
G
L
-
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
--
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
----
G
Y
D
E
N
G
---
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
---------------------
N
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
--
D
---
K
MN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-
K
Q
-
N
-
G
G
T
F
G
L
S
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
V
-
24
PsiBlast_CBE
90.91
43%
-80
- C3 -
1WDL
1
FADA_PSEFR
D:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
-----------
M
M----
H
--
G
V
--
D
P
-------------
N
--
P
----
H
--
M
S
--------------
L
Y
----
A
A
-
K
A
S
G
M
M
G
L
-
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
--
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
----
G
Y
D
E
N
G
---
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
---------------------
N
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
--
D
---
K
MN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-
K
Q
-
N
-
G
G
T
F
G
L
S
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
V
-
25
PsiBlast_CBE
90.86
43%
-81
- C3 -
1WDK
2
FADA_PSEFR
D:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
-----------
M
M----
H
--
G
V
--
D
P
-------------
N
--
P
----
H
--
M
S
--------------
L
Y
----
A
A
-
K
A
S
G
M
M
G
L
-
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
--
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
----
G
Y
D
E
N
G
---
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
---------------------
N
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
--
D
---
K
MN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-
K
Q
-
N
-
G
G
T
F
G
L
S
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
V
-
8
PsiBlast_PDB
90.86
43%
-79
- C3 -
1WDM
1
FADA_PSEFR
C:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
G
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
S
K
V
D
P
G
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
-----------
M
M----
H
--
G
V
--
D
P
-------------
N
--
P
----
H
--
M
S
--------------
L
Y
----
A
A
-
K
A
S
G
M
M
G
L
-
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
--
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
----
G
Y
D
E
N
G
---
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
---------------------
N
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
--
D
---
K
MN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
-
K
Q
-
N
-
G
G
T
F
G
L
S
T
M
C
I
G
L
-
G
Q
G
I
A
T
V
F
E
R
V
-
122
HHSearch
90.71
38%
-84
- C3 -
1WL4
7
THIC_HUMAN
A:
[5-397]
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
F
-
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
--
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
C
-
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
-----------
H
-----
L
--
A
Y
L-
R
T
GV
K
I
G
E
M
PL----
T
--
D
SIL-
C
--
D
G
--------------
L
T
----
D
A
-
F
H
N
C
H
M
G
I
-
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
--
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
T
R
----
K
----
G
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
---------------------
L
T
DG
T
G
-
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
-
L
--
N
---
P
--
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
---
G
R
S
R
G
V
A
A
L
C
I
G
G
-
G
M
G
I
A
M
C
V
Q
R
E
-
78
PsiBlast_CBE
90.70
39%
-74
- C3 -
4B3I
1
Y0859_MYCTU
C:
[3-403]
-
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
-
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
-----------
M
-----
G
SD
G
G
--
A
M
-----
G
L
------
D
--
P
----
A
--
T
N
--------------
Y
D
----
V
M
---
F
V
P
Q
S
I
-
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
--
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
R
D
Q
N
----------
G
L
L
I
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
EGLAALGG
F
D
D
V
A
L
Q
K
Y
HWVE
K
I
--
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
-
I
--
P
---
D
--
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
---
N
A
R
R
A
L
I
T
L
C
I
G
G
-
G
M
G
V
A
T
I
I
E
R
V
-
77
PsiBlast_CBE
90.46
39%
-75
- C3 -
4B3I
5
Y0859_MYCTU
D:
[3-403]
-
E
E
A
F
I
Y
E
A
I
R
T
P
R
G
K
Q
K
N
G
S
L
H
E
V
K
P
L
S
L
V
V
G
L
I
D
E
L
R
K
R
-
H
P
D
L
D
E
N
L
I
S
D
V
I
L
G
C
V
S
P
V
G
D
Q
G
G
D
I
A
R
A
A
V
L
A
S
G
M
P
V
T
S
G
G
V
Q
L
N
R
F
C
A
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
S
R
V
P
-----------
M
-----
G
SD
G
G
--
A
M
-----
G
L
------
D
--
P
----
A
--
T
N
--------------
Y
D
----
V
M
---
F
V
P
Q
S
I
-
G
A
D
L
I
A
T
I
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
--
K
A
A
E
A
W
S
G
G
Y
F
A
K
S
V
V
P
V
R
D
Q
N
----------
G
L
L
I
L
D
H
D
E
H
M
R
P
D
T
T
K
E
G
L
A
K
L
K
P
A
F
EGLAALGG
F
D
D
V
A
L
Q
K
Y
HWVE
K
I
--
N
H
-
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
M
I
G
S
A
A
A
G
K
L
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
G
A
D
P
V
I
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
V
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
-
I
--
P
---
D
--
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
L
G
T
M
V
D
E
L
E
R
R
---
N
A
R
R
A
L
I
T
L
C
I
G
G
-
G
M
G
V
A
T
I
I
E
R
V
-
94
PsiBlast_CBE
78.48
35%
-76
- C3 -
4UBW
21
?
A:
[51-399]
-----------------------------------------
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
-----------
L
-----
G
--
A
N
--
A
G
-----
P
D
------
R
--------------------------------
S
W
-
D
I
D
L
P
N
Q
F
E
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
--
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
-
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
---------------------
E
G
---
G
-
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
-
P
--
D
---
M
--
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
-
E
R
-
T
-
D
Q
S
L
A
L
I
T
M
C
A
G
G
-
A
L
S
T
G
T
I
I
E
R
I
-
95
PsiBlast_CBE
77.78
35%
-76
- C3 -
4UBV
14
?
B:
[51-399]
-----------------------------------------
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
-----------
L
-----
G
--
A
N
--
A
G
-----
P
D
------
R
--
S
----
L
--
I
R
--------------
A
Q
----
S
W
-
D
I
D
L
P
N
Q
F
E
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
--
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
-
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
---------------------
E
G
---
G
-
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
-
P
--
D
---
M
--
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
-
E
R
-
T
-
D
Q
S
L
A
L
I
T
M
C
A
G
G
-
A
L
S
T
G
T
I
I
E
R
I
-