@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0225: (2016-03-13 )
MTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESNYRENINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLATLLGVHQGLGHNTFYFGGSKEQIAKYVPKLLSHELRTCFALTEPEHGSDVAGGLETVAERQGDTWVINGEKKWIGGAHVSDVIPVFAVNKKTGKPHCFVVRPEQDGVDIEVIDNKIALRIVPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTERKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRLRETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
Atome Classification :
(27 SA)
.........10........20........30........40........50......-..60........70....-....80........90........100.......110.......120.......130.......140.......150.......160..--.--....170.......180.......190.......200.......210.......220.......230.......240..-.....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTF
E
K
E
T
V
L
K
T
L
F
P
E
D
V
L
S
I
AKGLTD
G
E
V
E
F
L
Q
Q
V
D
S
L
L
E
S
N
Y
R
E
N
I
N
Q
HWIDATV
P
-
E
D
Y
F
K
D
L
GELNYFNNP
L
L
-YKDRPNAKM
P
S
Q
L
F
Q
F
F
M
S
Y
L
L
A
R
F
D
I
S
L
A
T
L
L
G
V
HQGLGHN
T
F
Y
FGG
S
K
E
Q
I
A
K
Y
V
P
K
L
L
S
H
E
L
R
T
C
F
ALTEPEHGS
D
V
A
G
G
L
E
T
V
A
E--R--QG
D
T
W
V
INGEKKWIGGA
H
V
SD
V
I
P
V
F
A
VNKKTGKP
H
C
F
V
V
RPEQDG
V
D
I
E
V
ID
N
K
I
A
L
R
IVPN
A
L
I
K
L
TNVKVD
E
A
D
R
L
-
Q
N
I
T
S
F
K
D
I
A
K
I
L
Y
STRAG
V
A
Y
M
ATGGM
A
G
A
L
R
A
T
L
D
Y
V
T
E
R
K
Q
FGKP
I
S
K
Y
Q
L
I
Q
E
K
L
A
M
M
Q
G
N
L
A
Q
A
M
A
T
C
A
Q
L
A
N
MQAHG
E
Y
D
E
V
A
T
S
T
A
K
M
M
N
A
L
R
L
R
E
T
V
AMGRGITGGNGILAD
D
Y
D
I
A
R
F
FSDA
E
A
I
Y
T
YEGT
H
E
I
N
A
L
V
I
G
R
ALTGDSAFV
92
HHSearch
98.51
36%
-86
- C2 -
2IX5
5
ACOX4_ARATH
A:
[45-429]
-------------
T
S
D
Y
Y
H
F
N
D
L
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
G
Y
G
C
P
----
G
L
S
I
T
A
N
A
I
A
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
A
S
G
-
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
-
A
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
K
21
PsiBlast_CBE
96.91
36%
-83
- C2 -
2IX5
5
ACOX4_ARATH
D:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
1
PsiBlast_PDB
96.64
36%
-81
- C2 -
2IX5
5
ACOX4_ARATH
A:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
23
PsiBlast_CBE
96.51
36%
-83
- C2 -
2IX5
5
ACOX4_ARATH
B:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
26
PsiBlast_CBE
96.35
36%
-81
- C2 -
2IX6
3
ACOX4_ARATH
D:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
22
PsiBlast_CBE
96.14
36%
-82
- C2 -
2IX5
5
ACOX4_ARATH
C:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
28
PsiBlast_CBE
95.99
36%
-81
- C2 -
2IX6
3
ACOX4_ARATH
B:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
2
PsiBlast_PDB
95.95
36%
-80
- C2 -
2IX6
2
ACOX4_ARATH
A:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
27
PsiBlast_CBE
95.92
36%
-80
- C2 -
2IX6
2
ACOX4_ARATH
C:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
24
PsiBlast_CBE
95.82
36%
-81
- C2 -
2IX6
3
ACOX4_ARATH
F:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
25
PsiBlast_CBE
95.65
36%
-80
- C2 -
2IX6
3
ACOX4_ARATH
E:
[55-428]
-----------------------
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
E
K
A
E
F
P
-
F
H
I
T
P
K
L
G
A
M
G
V
A
G
G
S
I
K
-
G
Y
G
C
P
G
L
S
I
T
A
N
A
I
A
---
T
A
E
I
A
R
V
D
A
S
C
S
T
F
I
L
V
H
S
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
-
A
S
G
L
G
T
T
A
T
--
K
--
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
T
T
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
-
P
G
V
N
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
Q
M
T
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
-
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
F
-
96
HHSearch
94.58
31%
-87
- C2 -
3SF6
17
?
A:
[26-403]
-------------------
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
G
E
L
P
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
G
Y
G
C
A
----
G
M
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
G
-
M
R
T
R
A
T
--
R
--
S
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
E
--
G
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
-
P
G
A
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
-
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
4
PsiBlast_PDB
94.44
30%
-82
- C2 -
3SF6
17
?
A:
[21-402]
--------------
D
D
L
I
G
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
G
E
L
P
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
---
K
G
Y
G
C
A
G
M
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
-
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
G
-
M
R
T
R
A
T
--
R
--
S
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
D
E
G
I
R
G
--
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
-
P
G
A
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
-
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
-
30
PsiBlast_CBE
94.33
31%
-88
- C2 -
2EBA
3
?
H:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
3
PsiBlast_PDB
94.23
31%
-90
- C2 -
2EBA
3
?
A:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
31
PsiBlast_CBE
94.22
31%
-87
- C2 -
2EBA
3
?
G:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
35
PsiBlast_CBE
94.04
31%
-88
- C2 -
2EBA
3
?
C:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
32
PsiBlast_CBE
93.73
31%
-88
- C2 -
2EBA
3
?
F:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
34
PsiBlast_CBE
93.57
31%
-87
- C2 -
2EBA
3
?
D:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
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L
A
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L
A
W
H
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G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
29
PsiBlast_CBE
93.52
31%
-88
- C2 -
2EBA
3
?
I:
[3-385]
---------------
D
F
Y
A
L
E
D
L
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
H
I
R
D
W
W
E
E
G
V
F
P
-
T
H
L
I
P
R
F
A
E
L
G
F
L
G
-
P
T
L
-
P
P
E
Y
G
G
A
G
V
S
S
A
A
Y
G
L
-
I
C
Y
E
L
E
R
V
D
S
G
L
R
S
F
V
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
E
E
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
G
L
T
E
P
D
G
G
S
D
P
Y
G
N
M
K
T
R
A
R
--
R
----
D
T
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
A
V
I
W
A
K
D
----
E
V
L
G
F
L
V
P
T
D
T
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
S
V
T
S
E
L
V
L
E
E
V
R
V
P
E
S
L
R
L
-
P
K
A
L
G
L
K
A
P
L
S
C
L
T
Q
A
R
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
H
T
E
G
L
L
L
A
W
R
L
A
R
L
K
D
E
G
K
L
T
P
A
Q
V
S
L
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
-
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
L
N
A
F
-
95
HHSearch
91.89
30%
-89
- C2 -
1SIQ
1
GCDH_HUMAN
A:
[8-389]
-----------------
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
E
V
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
K
G
Y
G
C
A
----
G
V
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
-
M
E
T
R
A
H
--
Y
NS
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
E
D
-
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
-
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
10
PsiBlast_PDB
81.90
33%
-79
- C2 -
1SIQ
1
GCDH_HUMAN
A:
[84-389]
--------------------------------------------------------------------------------------------------
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
-
M
E
T
R
A
H
Y
N
S
--
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
-
R
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
-
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
12
PsiBlast_PDB
81.66
33%
-81
- C2 -
2R0N
2
GCDH_HUMAN
A:
[86-391]
--------------------------------------------------------------------------------------------------
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
-
M
E
T
R
A
H
Y
N
S
--
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
-
R
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
-
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
11
PsiBlast_PDB
81.18
33%
-79
- C2 -
1SIR
2
GCDH_HUMAN
A:
[86-391]
--------------------------------------------------------------------------------------------------
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
-
M
E
T
R
A
H
Y
N
S
--
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
-
R
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
-
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
13
PsiBlast_PDB
78.58
32%
-82
- C2 -
2R0M
2
GCDH_HUMAN
A:
[86-391]
--------------------------------------------------------------------------------------------------
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
-
M
E
T
R
A
H
Y
N
S
--
S
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
-
R
C
E
D
G
C
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
-
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
D
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
50
PsiBlast_CBE
74.89
32%
-67
- C2 -
2DVL
2
?
B:
[78-370]
------------------------------------------------------------------------------------------------------
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
-
A
K
S
L
R
A
E
A
R
--
R
--
V
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
K
G
--
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
-
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
-------
51
PsiBlast_CBE
74.27
32%
-68
- C2 -
2DVL
2
?
A:
[78-370]
------------------------------------------------------------------------------------------------------
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
-
A
K
S
L
R
A
E
A
R
--
R
--
V
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
K
G
--
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
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