@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0226: (2016-03-13 )
MNFDWIKTRSDFDDDKPAVIDHAKQTSWTYQQLNARADNMAHYLTSQGVKKGDVIGIFAPNDIAILDLLFACFKTGAVFLPLNWRLNPKEIAAIVEDAQLKLLFYAEKHLSSLTDIDQNLLHMDIDVAQYDEIVNPDYHQPFQATPVEPQDLAALIYTSGTTGSPKGVMFSYESFVHNGANLELTYKFNSNYITIVSTPMFHVLGFNDTVLPVLMSGGTLILQRYFNGEELNDMIAQYHPTFIIMIPTMYYSTLRASNFNPENFRAMDYIIQGGSQPLPSIQAAFKQYGINIINGYGLTEAPLVLVNTPENSKRKPMSIGKAVMFVDARILDDNGEEVPTGEIGELAIKAKNVTPGYWNKPAETAKAFHGRYLLTGDLAKMDDDGDIFIIDRKKELIITGGENVLPSEVENALAEHPLVDRCVVVGYDHPKYGESIAAAIILREDEPHYAEILDQHMRSRLAGYKVPRMYVPVTHMPLNSTQKPDKLAIRQMMNDKVSQTL
Atome Classification :
(20 SA)
.....-....10........20..---.---.....30........40....-....50........60........70........80........90........100...-....110.....---------------.--.------..-----120-..--.....---.------.-------130.-----...-.--..140.....-.-----------.150----....--.....160.......170-......-.------.-.180..----....--.190.......200..----...---..210..----.....220--..--.---....230...------....240......-----.250..-----.....260.........270.......-----280..-...-..-.---290.......300---....-.------.-.-.310--....----....----------.320.-......330-..-..-.---....340.........-----350---....-.-----....360......-------.-------370-........380.......390.......400.......410.......420.......430.......440..----.---.-----...450......-.460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNF
D
W
-
I
KTRSDFDDDK
P
A
V
I
DHA---K---QTSW
T
Y
Q
Q
L
N
A
R
A
D
N
M
A
H
Y
L
T
-SQGVKKG
D
V
I
G
I
FAPN
D
I
A
I
L
D
L
L
F
A
C
F
KTG
A
V
F
L
P
LNWRL
N
P
K
E
I
A
A
I
V
EDA
Q
L
K
L
L
F
Y
-
A
E
K
H
L
--
S
S
L
T
D
---------------
I
--
D
------
Q
N
-----
L
---
L
H
--MDI
D
V
---
A
------
Q
-------
Y
D
EI-----VNP-D--YHQPFQATPV-
E
-----------
P
Q
------
D
L
A
A
--
L
I
YTSGTTGSPK
G
V
M
F
---
S
Y
E
S
F
V-H------N-GA
N
L
E
L
----
T
Y
K
F--NS
N
Y
I
T
I
VSTP
M
F
H
V
L----GFN---D
T
V
L
P
V
L
----MSG
G
T
L
I
L
--
Q
R
--Y---F
N
G
E
E
L
N
D
M
I
------
A
QYH
P
T
F
I
I
M
I
P
T
-----
M
Y
Y
S
T
L
-----RASNFN--P
E
N
F
R
A
M
D
Y
I
I
QGGSQP
L
P
-----
S
-
I
Q
A
-
A
F
K
-QY-G---
I
N
I
INGYGLTEA----
P
L
V
L
-
V
------N-T-PE----NSKR----KPMS----------IG
K
A
V
-
M
F
V
D
A
R
I
---LD-DN-G---EEVPT--GEI
G
E
L
A
I
K
-----A-----KNVT-P-----GYWNKP
A
E
T
A
K
A
F-------H-------
G
-
R
-
Y
L
L
TGDLAKMDDDG
D
I
F
I
I
DRK
K
E
L
I
I
TGGENV
L
P
S
E
V
E
N
A
L
AEHPLV
D
R
C
V
V
VGYDHPKY
G
E
S
I
A
A
A
I
I
L
RE----D---E-----P
H
Y
A
E
I
L
D
Q
H
M
R
-
S
R
LAGYKV
P
R
M
Y
V
P
VTHMPLNSTQ
K
P
D
K
L
A
I
R
Q
M
M
N
D
K
VSQTL
8
PsiBlast_PDB
92.93
26%
-108
- C2 -
3A9U
-
?
A:
[38-534]
----------------
K
P
C
L
I
N
G
A
---
N
---
G
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
-
Q
A
C
Y
Y
--
E
K
V
K
D
---------------
F
A
R
E
-------
D
-----
V
---
K
V
--
M
C
V
D
S
---
A
PDGCL-
H
-------
F
S
E
L
-----
T
Q
A
-
D
--
E
N
E
A
P
Q
V
D
-
I
-
S
-----------
P
D
------
D
V
V
A
--
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
---
T
H
K
G
L
I
-
T
S
V
A
Q
Q
V
D
-
G
D
N
P
N
L
----
Y
--
F
--
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
----
A
L
N
---
S
I
M
L
C
G
L
----
R
V
G
A
P
I
L
I
--
M
P
--
K
---
F
E
I
G
S
L
L
G
L
I
------
E
K
Y
K
V
S
I
A
P
V
V
P
P
-----
V
M
M
S
I
A
-----
K
S
P
D
L
D
--
K
H
D
L
S
S
L
R
M
I
K
S
-------E
L
E
D
-
T
-
V
R
A
-
K
F
P
-
Q
A
-
R
---
L
G
--
Q
G
Y
G
M
T
E
A
----
G
P
V
L
-
A
------
M
-
C
-
L
A
----
F
A
K
E
P
F
D
I
K
P
G
A
----------
C
G
T
V
V
-
R
N
A
E
M
K
I
---
V
D
P
E
T
-
G
---
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
-----
G
-----
D
Q
I
M
-
K
-----
G
Y
L
N
D
P
E
A
T
S
R
T
I
-------
D
-------
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
----
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
-
K
Q
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
----
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
L
A
---
1
PsiBlast_PDB
92.19
30%
-97
- C2 -
3R44
2
FAC13_MYCTU
A:
[17-516]
-
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
S
---
T
---
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
-
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
-
G
A
P
-----
S
A
P
V
---------------
I
--
D
------
A
I
-----
R
---
A
Q
--
A
D
P
P
G
---
T
------
V
-------
T
D
W
I
-----
G
A
D
-
S
--
L
A
E
R
L
R
S
A
A
A
D
E
-----------
P
A
VECGGD
D
N
L
F
--
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
---
T
H
E
S
V
H
-
S
------
A
-
A
S
S
W
A
S
----
T
I
D
V
--
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
----
A
L
T
----
T
V
I
F
S
A
----
M
R
G
V
T
L
I
S
--
M
P
--
Q
---
F
D
A
T
K
V
W
S
L
I
------
V
E
E
R
V
C
I
G
G
A
V
P
A
-----
I
L
N
F
M
R
-----
Q
V
P
E
F
A
--
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
-
P
M
P
--------
E
A
-
L
I
K
-
I
Y
-
A
A
K
N
I
E
V
V
Q
G
Y
A
L
T
E
S
CGGG
T
L
L
L
------------
S
E
----
D
A
L
R
----
K
A
G
S
----------
A
G
R
A
T
-
M
F
T
D
V
A
V
---
R
G
-
D
D
-
G
---
V
I
R
E
H
--
G
E
-
G
E
V
V
I
K
-----
S
-----
D
I
L
L
-
K
-----
E
Y
W
N
R
P
E
A
T
R
D
A
F
-------
D
-------
N
-
G
-
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
----
N
---
E
-----
V
S
E
Q
Q
I
V
-
E
Y
C
G
-
T
R
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
P
---
10
PsiBlast_PDB
91.71
26%
-102
- C2 -
3NI2
4
?
A:
[38-532]
----------------
K
P
C
L
I
N
G
A
---
N
---
G
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
-
Q
A
C
Y
Y
--
E
K
V
K
D
---------------
F
A
R
E
------
S
D
-----
V
---
K
V
--
M
C
V
D
S
---
A
PDGCL-
H
-------
F
S
E
L
-----
T
Q
A
-
D
--
E
N
E
A
P
Q
V
D
-
I
-
S
-----------
P
D
------
D
V
V
A
--
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
---
T
H
K
G
L
I
-
T
S
V
A
Q
Q
V
D
-
G
D
N
P
N
L
----
Y
--
F
--
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
----
A
L
N
---
S
I
M
L
C
G
L
----
R
V
G
A
P
I
L
I
--
M
P
--
K
---
F
E
I
G
S
L
L
G
L
I
------
E
K
Y
K
V
S
I
A
P
V
V
P
P
-----
V
M
M
S
I
A
-----
K
S
P
D
L
D
--
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
-
P
L
G
K
E
L
E
D
T
-
V
R
A
-
K
F
P
-
Q
A
-
R
---
L
G
--
Q
G
Y
G
M
T
E
A
----
G
P
V
L
-
A
------
M
-
C
-
L
A
----
F
A
K
E
P
F
D
I
K
P
G
A
----------
C
G
T
V
V
-
R
N
A
E
M
K
I
---
V
D
P
E
T
-
G
---
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
-----
G
-----
D
Q
I
M
-
K
-----
G
Y
L
N
D
P
E
A
T
S
R
T
I
-------
D
-------
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
----
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
-
K
Q
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
----
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-----
9
PsiBlast_PDB
91.14
26%
-104
- C2 -
3A9V
1
?
A:
[38-532]
----------------
K
P
C
L
I
N
G
A
---
N
---
G
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
-
Q
A
C
Y
Y
--
E
K
V
K
D
---------------
F
A
R
E
------
S
D
-----
V
---
K
V
--
M
C
V
D
S
---
A
PDGCL-
H
-------
F
S
E
L
-----
T
Q
A
-
D
--
E
N
E
A
P
Q
V
D
-
I
-
S
-----------
P
D
------
D
V
V
A
--
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
---
T
H
K
G
L
I
-
T
S
V
A
Q
Q
V
D
-
G
D
N
P
N
L
----
Y
--
F
--
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
----
A
L
N
---
S
I
M
L
C
G
L
----
R
V
G
A
P
I
L
I
--
M
P
--
K
---
F
E
I
G
S
L
L
G
L
I
------
E
K
Y
K
V
S
I
A
P
V
V
P
P
-----
V
M
M
S
I
A
-----
K
S
P
D
L
D
--
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
-
P
L
G
K
E
L
E
D
T
-
V
R
A
-
K
F
P
-
Q
A
-
R
---
L
G
--
Q
G
Y
G
M
T
E
A
----
G
P
V
L
-
A
------
M
-
C
-
L
A
----
F
A
K
E
P
F
D
I
K
P
G
A
----------
C
G
T
V
V
-
R
N
A
E
M
K
I
---
V
D
P
E
T
-
G
---
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
-----
G
-----
D
Q
I
M
-
K
-----
G
Y
L
N
D
P
E
A
T
S
R
T
I
-------
D
-------
K
-
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
----
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
-
K
Q
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
----
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-----
30
HHSearch
89.73
28%
-102
- C2 -
3R44
2
FAC13_MYCTU
A:
[17-515]
N
I
G
W
M
-
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
S
---
T
---
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
-
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
-
G
A
P
S
A
--
P
V
I
D
A
---------------
I
--
R
------
A
Q
-----
A
---
D
P
PG
T
V
T
D
W
I
G
A
D
------
S
-------
L
A
E
R
-----
L
R
--
S
--
A
A
A
D
E
P
A
V
E
C
-
G
-----------
G
D
------
D
N
L
F
--
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
---
T
H
E
S
V
H
-
S
------
A
-
A
S
S
W
A
S
----
T
I
D
V
--
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
----
A
L
T
---
T
-
V
I
F
S
A
----
M
R
G
V
T
L
I
S
--
M
P
--
Q
---
F
D
A
T
K
V
W
S
L
I
------
V
E
E
R
V
C
I
G
G
A
V
P
A
-----
I
L
N
F
M
R
-----
Q
V
P
E
F
A
--
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
-----
A
-
L
I
K
-
I
Y
A
-
A
K
-
N
---
I
E
V
V
Q
G
Y
A
L
T
E
S
----
C
G
G
G
-
T
L-----
L
-
L
-
S
E
----
D
A
L
R
----
K
A
G
S
----------
A
G
R
A
T
-
M
F
T
D
V
A
V
---
R
G
-
D
D
-
G
---
V
I
R
E
---
H
G
E
G
E
V
V
I
K
-----
S
-----
D
I
L
L
-
K
-----
E
Y
W
N
R
P
E
A
T
R
D
A
F
-------
D
-------
N
-
G
-
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
----
N
---------
E
V
S
E
Q
Q
I
V
E
Y
C
G
-
T
R
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
----
3
PsiBlast_PDB
88.79
29%
-98
- C2 -
5BUS
3
?
A:
[9-473]
---
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
-
Y
E
---
D
---
Q
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
-
D
------
S
S
F
E
K
---------------
K
--
E
------
Y
E
-----
H
---
I
V
--
Q
T
I
D
V
-------------------
D
E
L
-----
M
K
E
-
A
--
A
E
E
I
E
I
E
A
Y
M
-
Q
-----------
M
D
------
A
T
A
T
--
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
---
T
F
G
N
H
Y
-
F
------
S
-
A
V
S
S
A
L
----
N
L
G
I
--
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
----
G
L
S
----
A
L
F
K
S
V
----
I
Y
G
M
T
V
V
L
--
H
Q
--
R
---
F
S
V
S
D
V
L
H
S
I
------
N
R
H
E
V
T
M
I
S
A
V
Q
T
-----
M
L
A
S
L
L
-----
E
E
T
N
R
C
--
P
E
S
I
R
C
I
--
L
L
G
G
G
P
A
P
L
P
-----
L
-
L
E
E
-
C
-
R
-
E
K
-
G
---
F
P
V
F
Q
S
Y
G
M
T
E
T
----
C
S
Q
I
-
V
------
T
L
S
-
P
E
----
F
S
M
E
----
K
L
G
S
----------
A
G
K
P
L
-
F
S
C
E
I
K
I
----
E
-
R
D
-
G
---
Q
V
C
E
P
--
Y
E
H
G
E
I
M
V
K
-----
G
-----
P
N
V
M
-
K
-----
S
Y
F
N
R
E
S
A
N
E
A
S
F
-------
Q
-------
N
-
G
-
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
--
K
V
P
H
A
Y
L
V
L
H
---------
K
-----
P
V
S
A
G
E
L
T
D
Y
C
K
-
E
R
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
------------------
4
PsiBlast_PDB
88.66
28%
-105
- C2 -
4FUQ
7
?
A:
[13-500]
------------
L
D
D
P
H
K
L
A
I
E
T
A
---
A
---
G
D
K
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
-
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
I
V
V
C
-
D
P
S
K
R
--
D
G
I
A
A
---------------
I
--
A
------
A
K
-----------------
V
---
G
------
A
-------
T
V
E
T
-----
L
G
P
-
D
--
G
R
G
S
L
T
D
A
A
A
-
G
ASEAFATIDRG
A
D
------
D
L
A
A
--
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
L
---
S
H
D
N
L
A
-
S
------
N
-
S
L
T
L
V
D
----
Y
W
R
F
--
T
P
D
D
V
L
I
H
A
L
P
I
Y
H
T
H
----
G
L
F
---
V
A
S
N
V
T
L
----
F
A
R
G
S
M
I
F
--
L
P
--
K
---
F
D
P
D
K
I
L
D
L
M
------
A
R
--
A
T
V
L
M
G
V
P
T
-----
F
Y
T
R
L
L
-----
Q
S
P
R
L
T
--
K
E
T
T
G
H
M
R
L
F
I
S
G
S
A
P
L
L
A
-----
D
-
T
H
R
-
E
W
S
A
K
T
-
G
---
H
A
V
L
E
R
Y
G
M
T
E
T
----
N
M
N
T
-
S
------
N
---
P
Y
----
D
G
D
R
----
V
P
G
A
----------
V
G
P
A
L
-
P
G
V
S
A
R
V
---
T
D
P
E
T
-
G
---
K
E
L
P
R
--
G
D
I
G
M
I
E
V
K
-----
G
-----
P
N
V
F
-
K
-----
G
Y
W
R
M
P
E
K
T
K
S
E
F
-------
R
-------
D
D
G
-
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
D
F
G
E
G
V
T
A
V
V
V
R
D
K
GATI
D
---
E
-----
A
Q
V
L
H
G
L
D
-----
G
Q
L
A
K
F
K
M
P
K
K
V
I
F
V
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
E
T
Y
K
D
------
2
PsiBlast_PDB
87.66
29%
-98
- C2 -
5BUR
9
?
A:
[9-473]
---
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
-
Y
E
---
D
---
Q
T
V
-
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
-
D
------
S
S
F
E
K
---------------
K
--
E
------
Y
E
-----
H
---
I
V
--
Q
T
I
D
V
-------------------
D
E
L
-----
M
K
E
-
A
--
A
E
E
I
E
I
E
A
Y
M
-
Q
-----------
M
D
------
A
T
A
T
--
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
---
T
F
G
N
H
Y
-
F
------
S
-
A
V
S
S
A
L
----
N
L
G
I
--
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
----
G
L
S
----
A
L
F
K
S
V
----
I
Y
G
M
T
V
V
L
--
H
Q
--
R
---
F
S
V
S
D
V
L
H
S
I
------
N
R
H
E
V
T
M
I
S
A
V
Q
T
-----
M
L
A
S
L
L
-----
E
E
T
N
R
C
--
P
E
S
I
R
C
I
--
L
L
G
G
G
P
A
P
L
P
-----
L
-
L
E
E
-
C
-
R
-
E
K
-
G
---
F
P
V
F
Q
S
Y
G
M
T
E
T
----
C
S
Q
I
-
V
------
T
L
S
-
P
E
----
F
S
M
E
----
K
L
G
S
----------
A
G
K
P
L
-
F
S
C
E
I
K
I
----
E
-
R
D
-
G
---
Q
V
C
E
P
--
Y
E
H
G
E
I
M
V
K
-----
G
-----
P
N
V
M
-
K
-----
S
Y
F
N
R
E
S
A
N
E
A
S
F
-------
Q
-------
N
-
G
-
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
Y
L
V
L
H
---------
K
-----
P
V
S
A
G
E
L
T
D
Y
C
K
-
E
R
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
------------------
6
PsiBlast_PDB
87.45
28%
-106
- C2 -
1ULT
1
LCFCS_THET8
A:
[49-536]
-----------------------------------
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
-
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
-
D
P
N
L
L
--
P
L
V
E
A
---------------
I
--
R
GELKTV
Q
H
-----
F
---
V
V
--
M
D
E
K
A
---
P
------
E
GYLA---
Y
E
E
A
-----
L
G
E
---------
E
A
D
P
V
-
R
-----------
V
P
------
E
R
A
A
C
G
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
---
S
H
R
A
L
V
L
H
------
S
L
A
A
S
L
V
D
----
G
T
A
L
--
S
E
K
D
V
V
L
P
V
V
P
M
F
H
V
N
----
A
W
C
---
L
P
Y
A
A
T
L
----
V
G
A
K
Q
V
L
P
--
G
P
--
R
---
L
D
P
A
S
L
V
E
L
F
------
D
G
E
G
V
T
F
T
A
G
V
P
T
-----
V
W
L
A
L
A
-----
D
Y
L
E
S
T
--
G
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
A
P
R
-----
S
-
L
I
A
-
R
F
E
-
R
M
-
G
---
V
E
V
R
Q
G
Y
G
L
T
E
T
----
S
P
V
V
-
V
------
Q
-
N
-
F
V
----
K
S
H
L
----
E
S
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
-
P
L
V
R
L
R
V
---
A
D
-
E
E
-
G
---
R
P
V
P
K
DG
K
A
L
G
E
V
Q
L
K
-----
G
-----
P
W
I
T
-
G
-----
G
Y
Y
G
N
E
E
A
T
R
S
A
L
-------
T
P------
D
-
G
-
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
K
W
Q
E
R
P
L
A
V
V
V
P
R
G
----
E
---
K
-----
P
T
P
E
E
L
N
E
H
L
L
K
-
A
G
F
A
K
W
Q
L
P
D
A
Y
V
F
A
E
E
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
Q
Y
K
N
------
32
HHSearch
85.13
24%
-91
- C2 -
3NI2
4
?
A:
[24-532]
-
L
H
S
Y
-
V
L
E
N
L
S
N
H
S
S
K
P
C
L
I
N
G
A
---
N
---
G
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
-
Q
A
C
Y
Y
--
E
K
V
K
D
---------------
F
--
A
------
R
E
-----
S
D--
V
K
--
V
M
C
V
D
---
S
------
A
-------
P
D
G
C
LH
F
S
E
L
T
Q
-
A
--
D
E
N
E
A
P
Q
V
D
I
-
S
-----------
P
D
------
D
V
V
A
--
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
---
T
H
K
G
L
I
-
T
------
S
-
V
A
Q
Q
V
D
GDNP
N
L
Y
F
--
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
----
A
L
N
---
S
I
M
L
C
G
L
----
R
V
G
A
P
I
L
I
--
M
P
--
K
---
F
E
I
G
S
L
L
G
L
I
------
E
K
Y
K
V
S
I
A
P
V
V
P
P
-----
V
M
M
S
I
A
-----
K
S
P
D
L
D
--
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
-----
E
-
L
E
D
T
V
R
A
-
K
F
P
Q
---
A
R
L
G
Q
G
Y
G
M
T
E
A
----
G
P
V
L
-
A
------
M
-
C
-
L
A
FAKE
P
F
D
I
----
K
P
G
A
----------
C
G
T
V
V
-
R
N
A
E
M
K
I
---
V
D
-
P
E
T
G
---
A
S
L
P
R
--
N
Q
P
G
E
I
C
I
R
-----
G
-----
D
Q
I
M
-
K
-----
G
Y
L
N
D
P
E
A
T
S
R
T
I
-------
D
K------
E
-
G
-
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
E
----
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
-
K
Q
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
---------
22
HHSearch
83.26
23%
-98
- C2 -
3ETC
11
?
A:
[58-559]
-
A
Y
D
V
-
V
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
D
DYG
N
---
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
-
I
A
E
D
D
V
P
E
Q
V
D
E
---------------
A
--
H
------
A
E
C
GDIP
L
---
K
K
--
A
K
V
G
G
---
D
VLEGWI
D
-------
F
R
K
E
-----
L
E
E
S
S
PI
F
E
R
P
T
G
E
V
S
T
-
K
-----------
N
E
------
D
I
C
L
--
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
---
D
N
T
Y
P
L
-
G
------
H
-
I
L
T
A
K
Y
----
W
Q
N
V
--
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
----
C
V
W
---
G
K
L
Y
G
Q
W
----
I
A
G
C
A
V
F
V
--
Y
D
YD
R
---
F
E
A
K
N
M
L
E
K
A
------
S
K
Y
G
V
T
T
F
C
A
P
P
T
-----
I
Y
R
F
L
I
-----
K
E
D
L
------
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
-----
E
-
V
F
N
R
F
L
E
-
F
T
-
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
----
V
V
T
I
-
A
------
T
-
F
-
P
W
-----
M
E
P
----
K
P
G
S
----------
I
G
K
P
T
-
P
G
Y
K
I
E
L
---
M
D
-
R
D
-
G
---
R
L
C
E
V
--
G
E
E
G
E
I
V
I
N
-----
T
MEGKP
V
G
L
F
-
V
-----
H
Y
G
K
D
P
E
R
T
E
E
T
W
-------
H
-------
D
-
G
-
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
----
D
---
Y
T
P
S
--
D
S
L
K
N
E
L
Q
D
H
V
K
-
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
--------------------------
18
PsiBlast_PDB
82.82
24%
-100
- C2 -
3ETC
11
?
A:
[80-559]
---------------------
D
Y
G
---
N
---
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
V
--
P
E
Q
V
D
E
A
H
A
E
C
GDIP
L
K
K
A
K
V
--
G
------
G
D
-----
V
---
L
E
--
G
W
I
D
F
---
R
------
K
-------
E
L
E
E
-----
S
S
P
-
I
--
F
E
R
P
T
G
E
V
S
T
-
K
-----------
N
E
------
D
I
C
L
--
V
Y
F
S
S
G
T
A
G
F
P
K
-----------
M
V
-
E
------
H
-
D
N
T
Y
P
L
----
G
H
I
L
--
T
A
K
Y
W
Q
N
V
E
D
D
G
L
H
Y
T
VADS
G
W
G
---
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
--
Y
D
--
Y
DR-
F
E
A
K
N
M
L
E
K
A
------
S
K
Y
G
V
T
T
F
C
A
P
P
T
-----
I
Y
R
F
L
I
-----
K
-
E
D
L
-----
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
-----
E
-
V
F
N
-
R
F
L
-
E
F
T
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
----
V
V
T
I
-
A
------
T
-
F
-
P
W
-----
M
E
P
----
K
P
G
S
----------
I
G
K
P
T
-
P
G
Y
K
I
E
L
---
M
D
-
R
D
-
G
---
R
L
C
E
V
--
G
E
E
G
E
I
V
I
N
-----
T
-----
M
E
G
K
-
P
VGLFV
H
Y
G
K
D
P
E
R
T
E
E
T
W
-------
H
-------
D
-
G
-
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
----
D
Y
T
P
S
-----
D
S
L
K
N
E
L
Q
D
H
V
K
-
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
--------------------------
27
HHSearch
81.64
23%
-98
- C2 -
3C5E
7
ACS2A_HUMAN
A:
[54-562]
-----------
G
K
R
P
P
S
P
A
L
W
W
V
N
---
G
KG
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
-
G
D
E
V
I
--
Q
E
V
D
T
---------------
V
--
A
------
S
E
-----
C
PSL
R
I
--
K
L
L
V
S
---
E
------
K
S
C
D
GWLN
F
K
K
L
-----
L
N
--
E
--
A
S
T
T
H
H
C
V
E
T
-
G
-----------
S
Q
------
E
A
S
A
--
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
---
S
Y
S
S
L
G
-
L
------
K
-
A
K
M
D
A
G
----
W
T
G
L
--
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
----
N
I
L
---
C
S
L
M
E
P
W
----
A
L
G
A
C
T
F
V
H
L
L
P
--
K
---
F
D
P
L
V
I
L
K
T
L
------
S
S
Y
P
I
K
S
M
M
G
A
P
I
-----
V
Y
R
M
L
L
-----
Q
Q
D
L
-
S
--
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
-----
E
-
T
L
E
N
W
R
A
-
Q
T
-
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
----
G
L
T
C
-
M
------
V
-
S
-
K
T
-----
M
K
I
----
K
P
G
Y
----------
M
G
T
A
A
-
S
C
Y
D
V
Q
I
---
I
D
-
D
K
-
G
---
N
V
L
P
P
--
G
T
E
G
D
I
G
I
R
VKP
I
R
P
-----
I
G
I
F
-
S
-----
G
Y
V
D
N
P
D
K
T
A
A
N
I
-------
R
-------
G
-
D
-
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
----
Q
---
F
LSHD
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
-
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------
13
PsiBlast_PDB
81.32
26%
-109
- C2 -
4D4I
4
?
A:
[46-515]
------------------
A
V
A
V
L
S
---
E
---
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
-
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
-
Q
T
Q
W
S
--
N
L
I
S
D
---------------
Y
--
Q
------
G
Q
-----
V
---
I
C
--
L
D
------
S
------
Q
-------
W
A
K
I
-----
A
S
-----
Y
S
Q
E
N
L
V
N
T
V
-
N
-----------
P
E
------
N
L
A
Y
--
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
---
E
H
Q
S
L
V
-
N
------
F
-
T
K
L
A
I
A
----
Q
Y
Q
I
--
T
T
S
D
R
T
L
----
Q
F
V
S
I
----
S
F
D
V
A
A
E
E
I
Y
V
T
L
----
C
S
G
A
T
L
I
L
--
R
T
---------
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
-----
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
L
--
P
D
S
L
R
---
L
V
I
I
G
G
E
R
V
Q
P
-----
E
L
V
R
M
-
W
F
K
-
N
V
-
G
NF-
P
E
L
I
N
V
Y
G
P
T
E
G
----
T
I
A
V
-
S
L
C
RLSQ
L
-
T
-
E
S
----
Q
R
N
R
----
T
E
I
P
----------
I
G
K
S
L
G
E
N
I
S
V
Y
V
---
L
D
-
E
T
-
L
---
K
T
V
P
P
--
E
T
P
G
E
I
Y
I
G
-----
G
-----
T
A
L
A
-
R
-----
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQDPFSP
S
-------
E
-
R
-
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
H
S
----
T
---
E
-----
E
N
L
T
V
T
L
Q
Q
F
L
K
-
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
-----------------------------
14
PsiBlast_PDB
81.16
26%
-107
- C2 -
4D56
5
?
A:
[46-516]
------------------
A
V
A
V
L
S
---
E
---
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
-
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
-
Q
T
Q
W
S
--
N
L
I
S
D
---------------
Y
--
Q
------
G
Q
-----
V
---
I
C
--
L
D
------
S
------
Q
-------
W
A
K
I
-----
A
S
-----
Y
S
Q
E
N
L
V
N
T
V
-
N
-----------
P
E
------
N
L
A
Y
--
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
---
E
H
Q
S
L
V
-
N
------
F
-
T
K
L
A
I
A
----
Q
Y
Q
I
--
T
T
S
D
R
T
L
----
Q
F
V
S
I
----
S
F
D
V
A
A
E
E
I
Y
V
T
L
----
C
S
G
A
T
L
I
L
--
R
T
---------
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
-----
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
L
--
P
D
S
L
R
---
L
V
I
I
G
G
E
R
V
Q
P
-----
E
L
V
R
M
-
W
F
K
-
N
V
-
G
NF-
P
E
L
I
N
V
Y
G
P
T
E
G
----
T
I
A
V
-
S
LCRLSQ
L
-
T
-
E
S
----
Q
R
N
R
----
T
E
I
P
----------
I
G
K
S
L
G
E
N
I
S
V
Y
V
---
L
D
-
E
T
-
L
---
K
T
V
P
P
--
E
T
P
G
E
I
Y
I
G
-----
G
-----
T
A
L
A
-
R
-----
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQDPFSP
S
-------
E
-
R
-
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
H
S
----
T
---
E
-----
E
N
L
T
V
T
L
Q
Q
F
L
K
-
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
----------------------------
19
PsiBlast_PDB
80.99
26%
-96
- C2 -
2QVX
1
?
X:
[17-502]
---------------
D
H
C
A
L
A
V
P
A
---
R
---
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
-
A
V
G
R
Q
--
V
A
D
A
I
---------------
F
--
Q
------
S
G
-----
S
---
G
A
--
R
I
I
F
L
---
G
------
D
-------
L
V
R
D
-----
G
E
P
Y
S
--
Y
G
P
P
I
E
D
P
Q
R
-
E
-----------
P
A
------
Q
P
A
F
--
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
I
PQR
A
A
E
S
R
V
-
L
------
F
--
M
S
T
Q
V
----
G
L
R
H
--
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
----
G
F
F
---
A
V
L
V
A
A
L
----
A
L
D
G
T
Y
V
V
--
V
E
--
E
---
F
R
P
V
D
A
L
Q
L
V
------
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
HLDAL
A
A
A
A
A
H
-----
A
G
S
S
L
K
--
L
D
S
L
R
H
V
T
F
--
A
G
A
T
M
P
D
A
-----
V
-
L
E
T
-
V
H
Q
-
H
L
-
P
---
G
E
K
V
N
G
Y
G
T
T
E
A
----
M
N
S
L
Y
M
------
R
-
Q
-
P
K
----
T
G
T
E
------
M
A
----------
P
G
----
F
F
S
E
V
R
I
---
V
R
-
I
G
-
G
GVD
E
I
V
A
N
--
G
E
E
G
E
L
I
V
A
-----
A
-----
S
D
S
A
F
V
-----
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-------
Q
-------
D
-
G
-
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
----
G
---
E
-----
T
L
S
A
D
A
L
D
T
F
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
----
V
L
R
R
Q
L
V
Q
Q
V
----
41
HHSearch
80.63
24%
-98
- C2 -
1T5H
1
?
X:
[3-503]
T
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
A
---
R
---
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
-
A
V
--
Q
VA
D
A
I
F
Q
---------------
S
--
G
------
S
G
---------
A
R
--
I
I
F
L
G
---
D
------
L
-------
V
R
D
G
-----
E
P
Y
-
S
--
Y
G
P
P
I
E
D
P
Q
R
-
E
-----------
P
A
------
Q
P
A
F
--
I
F
Y
T
S
---
G
L
P
K
A
A
I
I
---
P
Q
R
A
A
E
-
S
------
R
-
V
L
F
M
S
T
----
Q
V
G
L
RH
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
----
G
F
F
---
A
V
L
V
A
A
L
----
A
L
D
G
T
Y
V
V
--
V
E
--
E
---
F
R
P
V
D
A
L
Q
L
V
------
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
-----
H
L
D
A
L
A
-----
A
A
A
A
H
A
GS
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
-----
A
-
V
L
E
T
V
H
Q
-
H
L
-
P
---
G
E
K
V
N
I
Y
G
T
T
E
A
----
M
N
S
L
-
Y
------
M
-
R
-
Q
P
----
K
T
--------
G
T
----------
E
M
A
P
G
-
F
F
S
E
V
R
I
VRI
G
G
-
G
V
-
D
---
E
I
V
A
N
--
G
E
E
G
E
L
I
V
A
-----
A
S----
D
S
A
F
-
V
-----
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-------
Q
-------
D
-
G
-
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
----
G
---
E
-----
T
L
S
A
D
A
L
D
T
F
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-------
36
HHSearch
80.39
23%
-99
- C2 -
2VSQ
2
A:
[466-977]
-
L
T
Y
W
-
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
-----
S
---
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
-
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
-
H
Q
E
M
K
--
E
Q
A
A
E
---------------
L
--
P
------
Y
T
---------
G
T
--
T
L
F
I
D
---
D
------
Q
-------
T
--
R
-----
F
---
E
--
E
Q
A
S
D
P
A
T
A
I
-
D
-----------
P
N
------
D
P
A
Y
--
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
---
T
H
A
N
I
Q
-
G
------
L
-
V
K
H
V
-
D
----
Y
M
A
F
--
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
----
F
T
F
----
D
F
Y
A
S
M
----
L
N
A
A
R
L
I
I
--
A
D
--
E
HTL
L
D
T
E
R
L
T
D
L
I
------
L
Q
E
N
V
N
V
M
F
A
T
T
A
-----
L
F
N
L
L
T
-----
D
A
G
E
-----
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
-----
P
-
H
V
R
K
A
L
R
-
I
M
G
P
---
G
K
L
I
N
C
Y
G
P
T
E
G
----
T
V
F
A
-
T
------
A
-
H
V
V
H
D
L--
P
D
S
I
----
S
S
L
P
----------
I
G
K
P
I
-
S
N
A
S
V
Y
I
---
L
N
-
E
Q
-
S
---
Q
L
Q
P
F
--
G
A
V
G
E
L
C
I
S
-----
G
-----
M
G
V
S
-
K
-----
G
Y
V
N
R
A
D
L
T
K
E
K
F
-------
I
ENPFKPG
E
-
T
-
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
----
Q
----------
L
S
A
E
D
V
K
A
H
L
K
-
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
------
15
PsiBlast_PDB
80.37
26%
-109
- C2 -
4D57
5
?
A:
[46-516]
------------------
A
V
A
V
L
S
---
E
---
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
-
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
-
Q
T
Q
W
S
--
N
L
I
S
D
---------------
Y
--
Q
------
G
Q
-----
V
---
I
C
--
L
D
------
S
------
Q
-------
W
A
K
I
-----
A
S
-----
Y
S
Q
E
N
L
V
N
T
V
-
N
-----------
P
E
------
N
L
A
Y
--
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
---
E
H
Q
S
L
V
-
N
------
F
-
T
K
L
A
I
A
----
Q
Y
Q
I
--
T
T
S
D
R
T
L
----
Q
F
V
S
I
----
S
F
D
V
A
A
E
E
I
Y
V
T
L
----
C
S
G
A
T
L
I
L
--
R
T
---------
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
-----
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
L
--
P
D
S
L
R
---
L
V
I
I
G
G
E
R
V
Q
P
-----
E
L
V
R
M
-
W
F
K
-
N
V
-
G
NF-
P
E
L
I
N
V
Y
G
P
T
E
G
----
T
I
A
V
-
S
LCRLSQ
L
-
T
-
E
S
----
Q
R
N
R
----
T
E
I
P
----------
I
G
K
S
L
G
E
N
I
S
V
Y
V
---
L
D
-
E
T
-
L
---
K
T
V
P
P
--
E
T
P
G
E
I
Y
I
G
-----
G
-----
T
A
L
A
-
R
-----
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQDPFSP
S
-------
E
-
R
-
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
H
S
----
T
---
E
-----
E
N
L
T
V
T
L
Q
Q
F
L
K
-
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
----------------------------
11
PsiBlast_PDB
79.92
26%
-106
- C2 -
4D4G
4
?
A:
[46-514]
------------------
A
V
A
V
L
S
---
E
---
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
-
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
-
Q
T
Q
W
S
--
N
L
I
S
D
---------------
Y
--
Q
------
G
Q
-----
V
---
I
C
--
L
D
------
S
------
Q
-------
W
A
K
I
-----
A
S
-----
Y
S
Q
E
N
L
V
N
T
V
-
N
-----------
P
E
------
N
L
A
Y
--
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
---
E
H
Q
S
L
V
-
N
------
F
-
T
K
L
A
I
A
----
Q
Y
Q
I
--
T
T
S
D
R
T
L
----
Q
F
V
S
I
----
S
F
D
V
A
A
E
E
I
Y
V
T
L
----
C
S
G
A
T
L
I
L
--
R
T
---------
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
-----
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
L
--
P
D
S
L
R
---
L
V
I
I
G
G
E
R
V
Q
P
-----
E
L
V
R
M
-
W
F
K
-
N
V
-
G
NF-
P
E
L
I
N
V
Y
G
P
T
E
G
----
T
I
A
V
-
S
LCRLSQ
L
-
T
-
E
S
----
Q
R
N
R
----
T
E
I
P
----------
I
G
K
S
L
G
E
N
I
S
V
Y
V
---
L
D
-
E
T
-
L
---
K
T
V
P
P
--
E
T
P
G
E
I
Y
I
G
-----
G
-----
T
A
L
A
-
R
-----
G
Y
L
N
R
P
E
L
T
A
Q
K
F
IQDPFSP
S
-------
E
-
R
-
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
H
S
----
T
---
E
-----
E
N
L
T
V
T
L
Q
Q
F
L
K
-
N
K
L
P
S
Y
M
I
P
A
T
F
V
------------------------------