@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0231: (2016-03-13 )
MLTEQEKDIIKQTVPLLKEKGTEITSIFYPKMFKAHPELLNMFNQTNQKRGMQSSALAQAVMAAAVNIDNLSVIKPVIMPVAYKHCALQVYAEHYPIVGENLLKAIQDVTGLEEHDPVIQAWAKAYGVIADVFIQIEKEIYDQMMWIGFKPFKITNIKQESEDIKSFTVETEEYDFSEFTPGQYITVDVSSDKLPYRAKRHYSIVSGEKNHLTFGVKRDVTTEHEGEVSTILHDEIKEGDMINLAAPVGGFVLENTTEPQLFLGSGIGVTPLVAMYEAASAKGLDTQMVQVAENEQHLPFKDNFNSIASHYDNAKLYTHLKDKQGYIGTEELQAFLANKPEIYICGGTKFLQSMIEALKSLNYDMDRVHYETFIPRLSVAV
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-----..-----.-----....150.......160.......170.-----.-..-....180.......190...--....200......-.210...--.....-220-..--.....230.......240.......250----...-..-..-.260.......270.......-280.--...--..--.290.......300.......-310..-.....320---.------------..------------..----....330----.-....-..340........350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
T
E
Q
E
K
D
I
I
K
Q
T
V
P
L
L
K
EKGTE
I
T
S
I
F
Y
P
K
M
F
K
A
H
P
E
L
L
N
M
F
N
Q
T
N
Q
KRG
M
Q
S
S
A
L
A
Q
A
V
M
A
A
A
VNIDN
L
S
V
I
K
P
V
I
M
P
V
A
Y
K
H
C
A
L
Q
V
Y
A
E
HYPI
V
G
E
N
L
L
K
A
I
Q
D
VTGLEEH
D
P
V
I
Q
A
W
A
K
A
Y
G
V
I
A
D
V
F
I
Q
I
E
K
E
I
Y
D
-----
Q
M
-----
M
-----
W
IGFKP
F
K
I
TNIK
Q
E
S
E
D
I
K
S
F
T
V
E-TE-----E-YD-FSEFTPG
Q
Y
I
T
V
DVSSDKLP--YRAK
R
H
Y
S
IVSGE-KN-
H
L
T
F
--GVKRD-VTT-EH--EG
E
V
S
T
I
L
H
D
E
IKEG
D
M
I
N
LAAPVG
G
F
-----
V
LE-NT-TE-P
Q
L
F
LGSGIG
V
T
P
L
V
A
M
Y
E
A
A-SAKG--L
D
T
--
Q
M
--
V
Q
VAENEQHLPFKDN
F
N
S
I
A
S
-
H
YDN
A
-
K
L
Y
T
H
L-----K------------DK------------QG----YI
G
T
E
E
L
----
Q
-
A
F
LA-NK
P
-
E
I
Y
I
CG
G
T
K
F
L
Q
S
M
I
E
A
L
K
SLNY
D
M
D
R
V
H
Y
E
T
FIPRLSVAV
2
PsiBlast_PDB
92.20
41%
-94
- C1 -
4G1V
4
?
A:
[2-395]
-
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
-----
E
A
-----
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
-
P
K
FGSGI
E
-
L
E
-
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
NQ
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
-
G
L
R
F
--
A
V
K
M
E
-
A
A
R
-
E
N
FP
A
G
L
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
AINKE
L
I
H
-
Q
N
-
E
V
-
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
-
V
K
C
N
--
P
N
R
--
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
V
H
------
T
------------
D
T
------------
E
P
----
L
I
N
A
A
F
L
----
K
-
E
K
S
P
-
A
H
A
-
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
---
1
PsiBlast_PDB
91.44
41%
-98
- C1 -
4G1B
3
?
A:
[1-395]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
-----
E
A
-----
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
-
P
K
F
GSGI
E
-
L
E
-
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
NQ
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
-
G
L
R
F
--
A
V
K
M
E
-
A
A
R
-
E
N
FP
A
G
L
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
AINKE
L
I
H
-
Q
N
-
E
V
-
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
-
V
K
C
N
--
P
N
R
--
P
I
Y
W
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
V
H
------
T
------------
D
T
------------
E
P
----
L
I
N
A
A
F
L
----
K
-
E
K
S
P
-
A
H
A
-
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
---
23
PsiBlast_CBE
90.81
41%
-98
- C1 -
4G1B
3
?
B:
[1-395]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
-----
E
A
-----
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
-
P
K
FGSGI
E
-
L
E
-
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
NQ
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
-
G
L
R
F
--
A
V
K
M
E
-
A
A
R
-
E
N
FP
A
G
L
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
AINKE
L
I
H
-
Q
N
-
E
V
-
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
-
V
K
C
N
--
P
N
R
--
P
I
YW
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
V
H
------
T
------------
D
T
------------
E
P
----
L
I
N
A
A
F
L
----
K
-
E
K
S
P
-
A
H
A
-
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
---
22
PsiBlast_CBE
90.46
41%
-98
- C1 -
4G1B
3
?
C:
[1-395]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
-----
E
A
-----
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
-
P
K
FGSGI
E
-
L
E
-
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
NQ
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
-
G
L
R
F
--
A
V
K
M
E
-
A
A
R
-
E
N
FP
A
G
L
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
AINKE
L
I
H
-
Q
N
-
E
V
-
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
-
V
K
C
N
--
P
N
R
--
P
I
YW
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
V
H
------
T
------------
D
T
------------
E
P
----
L
I
N
A
A
F
L
----
K
-
E
K
S
P
-
A
H
A
-
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
---
21
PsiBlast_CBE
90.15
41%
-95
- C1 -
4G1B
3
?
D:
[1-395]
M
L
A
E
K
T
R
S
I
I
K
A
T
V
P
V
L
E
Q
Q
G
T
V
I
T
R
T
F
Y
K
N
M
L
T
E
H
T
E
L
L
N
I
F
N
R
T
N
Q
K
V
G
A
Q
P
N
A
L
A
T
T
V
L
A
A
A
K
N
I
D
D
L
S
V
L
M
D
H
V
K
Q
I
G
H
K
H
R
A
L
Q
I
K
P
E
H
Y
P
I
V
G
E
Y
L
L
K
A
I
K
E
V
L
G
D
A
A
T
P
E
I
I
N
A
W
G
E
A
Y
Q
A
I
A
D
I
F
I
T
V
E
K
K
M
Y
E
-----
E
A
-----
L
-----
W
P
G
W
K
P
F
E
I
T
A
K
E
Y
V
A
S
D
I
V
E
F
T
V
K
-
P
K
FGSGI
E
-
L
E
-
S
L
P
I
T
P
G
Q
Y
I
T
V
N
T
H
P
I
R
Q
E
NQ
Y
D
A
L
R
H
Y
S
L
C
S
A
S
T
K
N
-
G
L
R
F
--
A
V
K
M
E
-
A
A
R
-
E
N
FP
A
G
L
V
S
E
Y
L
H
K
D
A
K
V
G
D
E
I
K
L
S
A
P
A
G
D
F
AINKE
L
I
H
-
Q
N
-
E
V
-
P
L
V
L
L
S
S
G
V
G
V
T
P
L
L
A
M
L
E
E
Q
-
V
K
C
N
--
P
N
R
--
P
I
YW
I
Q
S
S
Y
D
E
K
T
Q
A
F
K
K
H
V
D
E
L
L
A
-
E
C
A
N
V
D
K
I
I
V
H
------
T
------------
D
T
------------
E
P
----
L
I
N
A
A
F
L
----
K
-
E
K
S
P
-
A
H
A
-
D
V
Y
T
C
G
S
L
A
F
M
Q
A
M
I
G
H
L
K
E
L
E
H
R
D
D
M
I
H
Y
E
P
F
G
P
K
M
S
---
64
Fugue
86.95
33%
-95
- C1 -
1GVH
5
HMP_ECOLI
A:
[1-396]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
--
P
G
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
-----
E
N
-----
A
S
KAGG
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
D
-----
G
-
G
A
-
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
P
E
G
F
P
--
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
-
D
G
K
G
Y
R
I
--
A
V
K
R
------
E
E
--
G
G
Q
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
-----
F
M
A
-
V
A
-
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
-
A
K
A
G
--
H
T
A
Q
V
N
W
--
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
-
S
L
P
R
F
-
T
A
H
T
W
Y
-----
R
QPS
E
A
D
R
A
K
GQF
D
S
------------
E
G
----
L
M
D
L
S
K
L
----
E
-
G
A
F
S
-
D
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
H
K
V
L
--
42
HHSearch
84.17
33%
-92
* C1 *
1GVH
5
HMP_ECOLI
A:
[1-396]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
P
--
G
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
K
A
G
-----
G
-----
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
-
P
V
-----
D
G
G
A
-
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
P
E
G
F
P
--
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
K
-
G
Y
R
I
--
A
V
K
R
E
------
E
--
G
G
Q
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
-----
F
M
A
-
V
A
D
D
T
-
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
-
A
K
A
G
HT
A
Q
V
--
N
W
--
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
S
L
P
R
-
F
-
T
A
H
T
W
Y
-----
R
------------
Q
P
S
E
A
D
R
A
K
GQFDS
E
G
----
L
M
D
L
S
K
L
----
E
-
G
A
F
S
D
P
T
M
-
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
H
K
V
L
--
4
PsiBlast_PDB
83.64
36%
-95
- C1 -
3OZU
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
E
QPGG
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
S
Y
R
I
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
7
PsiBlast_PDB
82.37
32%
-90
- C1 -
1GVH
5
HMP_ECOLI
A:
[1-392]
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
--
F
S
P
G
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
-----
E
N
-----
A
S
KAGG
W
E
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
D
-----
G
-
G
A
-
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
P
E
G
F
P
--
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
-
D
G
-
K
-----
G
Y
R
I
A
-
V
K
R
-
E
E
--
G
G
Q
V
S
N
W
L
H
N
H
A
N
V
G
D
V
V
K
L
V
A
P
A
G
D
F
-----
F
M
A
-
V
A
-
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
-
A
K
A
G
--
H
T
A
--
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
K
E
L
G
Q
-
S
L
P
R
F
-
T
A
H
T
W
Y
-----
R
QPS
E
A
D
R
A
K
GQF
D
S
------------
E
G
----
L
M
D
L
S
K
L
----
E
G
A
F
S
D
-
P
T
M
-
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
D
L
G
V
K
Q
E
N
I
H
Y
E
C
F
G
P
------
24
PsiBlast_CBE
81.75
37%
-97
- C1 -
1CQX
4
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
EQPGG
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
T
Y
RI
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
25
PsiBlast_CBE
81.69
36%
-95
- C1 -
3OZW
4
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
EQPGG
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
S
Y
RI
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
41
HHSearch
81.60
37%
-92
- C1 -
1CQX
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
A
E
QPG
G
-----
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
G
G
P
-
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
G
R
-
T
Y
R
I
--
S
V
K
R
E
-
G
G
G
P
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
-
V
D
A
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
-
L
Q
A
P
P-
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
N
-
L
-
D
L
F
V
F
Y
-----
D
------------
Q
P
LPEDVQGRDYDY
P
G
----
L
V
D
V
K
Q
I
----
E
-
K
S
I
L
L
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
6
PsiBlast_PDB
81.42
36%
-92
- C1 -
3OZW
5
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
E
QPGG
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
S
Y
R
I
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
3
PsiBlast_PDB
81.06
37%
-94
- C1 -
1CQX
4
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
E
QPG
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
T
Y
R
I
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
26
PsiBlast_CBE
80.50
36%
-91
- C1 -
3OZV
5
HMP_CUPNH
A:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
E
QPG
G
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
S
Y
R
I
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
5
PsiBlast_PDB
79.71
36%
-95
- C1 -
3OZV
5
HMP_CUPNH
B:
[1-400]
M
L
T
Q
K
T
K
D
I
V
K
A
T
A
P
V
L
A
E
H
G
Y
D
I
I
K
C
F
Y
Q
R
M
F
E
A
H
P
E
L
K
N
V
F
N
M
A
H
Q
E
Q
G
Q
Q
Q
Q
A
L
A
R
A
V
Y
A
Y
A
E
N
I
E
D
P
N
S
L
M
A
V
L
K
N
I
A
N
K
H
A
S
L
G
V
K
P
E
Q
Y
P
I
V
G
E
H
L
L
A
A
I
K
E
V
L
G
N
A
A
T
D
D
I
I
S
A
W
A
Q
A
Y
G
N
L
A
D
V
L
M
G
M
E
S
E
L
Y
E
-----
R
S
-----
A
EQPGG
W
K
G
W
R
T
F
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
-
P
A
-----
D
-
G
G
P
V
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L
G
--
L
Q
Q
I
R
Q
Y
S
L
-
S
D
M
-
P
N
-
G
R
S
Y
RI
S
V
K
R
E
G
G
G
P
-
Q
P
--
P
G
Y
V
S
N
L
L
H
D
H
V
N
V
G
D
Q
V
K
L
A
A
P
Y
G
S
F
-----
H
I
D
V
D
A
-
K
T
-
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P
P
--
R
Q
V
--
V
F
--
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
R
E
A
A
K
-
T
Y
E
N
L
-
D
L
F
V
F
Y
DQPLP
E
------------
D
V
------------
Q
G
RDYD
Y
P
G
L
V
D
V
KQIE
K
-
S
I
L
L
-
P
D
A
-
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
N
L
G
I
H
E
A
R
I
H
Y
E
V
F
G
P
D
L
----
27
PsiBlast_CBE
55.65
51%
-112
- C1 -
4VHB
2
BAHG_VITST
B:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
-------
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
54.65
51%
-116
- C1 -
2VHB
2
BAHG_VITST
B:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
-------
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.36
51%
-111
- C1 -
4VHB
2
BAHG_VITST
A:
[1-143]
M
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
--------
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
54.14
51%
-110
- C1 -
3VHB
2
BAHG_VITST
B:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
54.12
50%
-111
- C1 -
3TLD
3
BAHG_VITST
B:
[1-143]
M
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
F
K
N
L
F
A
K
H
P
E
V
R
P
L
F
D
M
G
--
E
S
L
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
54.07
51%
-111
- C1 -
1VHB
1
BAHG_VITST
B:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
53.72
51%
-114
- C1 -
3VHB
2
BAHG_VITST
A:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.64
51%
-112
- C1 -
2VHB
2
BAHG_VITST
A:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
--------
E
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.90
51%
-103
- C1 -
1VHB
1
BAHG_VITST
A:
[2-143]
-
L
D
Q
Q
T
I
N
I
I
K
A
T
V
P
V
L
K
E
H
G
V
T
I
T
T
T
F
Y
K
N
L
F
A
K
H
P
E
V
R
P
L
F
---------
Q
P
K
A
L
A
M
T
V
L
A
A
A
Q
N
I
E
N
L
P
A
I
L
P
A
V
K
K
I
A
V
K
H
C
Q
A
G
V
A
A
A
H
Y
P
I
V
G
Q
E
L
L
G
A
I
K
E
V
L
G
D
A
A
T
D
D
I
L
D
A
W
G
K
A
Y
G
V
I
A
D
V
F
I
Q
V
E
A
D
L
Y
A
-----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.27
43%
-101
- C1 -
2WY4
2
?
A:
[2-140]
--
T
K
E
Q
I
Q
I
I
K
D
C
V
P
I
L
Q
K
N
G
E
D
L
T
N
E
F
Y
K
I
M
F
N
D
Y
P
E
V
K
P
M
F
N
M
E
K
Q
I
S
G
E
Q
P
K
A
L
A
M
A
I
L
M
A
A
K
N
I
E
N
L
E
N
M
R
S
F
V
D
K
V
A
I
T
H
V
N
L
G
V
K
E
E
H
Y
P
I
V
G
A
C
L
L
K
A
I
K
N
L
--
L
N
P
D
E
A
T
L
K
A
W
E
V
A
Y
G
K
I
A
K
F
Y
I
D
I
E
K
K
L
Y
D
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
42.50
31%
-84
- C1 -
3UBC
2
?
D:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
41.55
31%
-86
- C1 -
3UBC
2
?
A:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
41.21
31%
-84
- C1 -
3UBC
2
?
G:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
40.82
31%
-84
- C1 -
3UBV
2
?
A:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
39.88
31%
-89
- C1 -
3UBV
2
?
G:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
39.31
31%
-82
- C1 -
3S1I
3
?
C:
[2-130]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
39.02
31%
-82
- C1 -
3S1I
2
?
A:
[2-130]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
38.65
31%
-85
- C1 -
3S1I
5
?
B:
[2-130]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
38.62
31%
-89
- C1 -
3UBV
2
?
D:
[1-129]
-
I
D
Q
K
E
K
E
L
I
K
E
S
W
K
R
I
E
P
N
K
N
E
I
G
L
L
F
Y
A
N
L
F
K
E
E
P
T
V
S
V
L
F
Q
N
P
I
S
S
---
Q
S
R
K
L
M
Q
V
L
G
I
L
V
Q
G
I
D
N
L
E
G
L
I
P
T
L
Q
D
L
G
R
R
H
K
Q
Y
G
V
V
D
S
H
Y
P
L
V
G
D
C
L
L
K
S
I
Q
E
Y
L
G
Q
G
F
T
E
E
A
K
A
A
W
T
K
V
Y
G
I
A
A
Q
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------