@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0234: (2016-03-13 )
MKRKIIMDCDPGHDDAIALILAGAIDSPLEILAVTTVAGNQSVDKNTTNALNVLDIMGRQDIAVAKGADRPLIKPAAFASEIHGESGLDGPKLPSTPSRQAVAMPASDVIINKVMTSDTPVTIVATGPLTNVATALIREPRIAEHIESITLMGGGTFGNWTPTAEFNIWVDAEAAKRVFESGITINVFGLDVTHQVLADNHVIERFESINNPVAQFVVELLQFFKKTYKTHFNMDGGPIHDACTILYLLQPELFTMVPVNIDIEHQSPLTYGTMAVDLNHVTGKPANAYFATAVDVEEVWNLIDHKLRTYE
Atome Classification :
(27 SA)
.........10........20.......-.30........40........50........60........70........80........90........-100.......110.....-.-.-120.......130.......140.......150..--.-.-.-..160.......170.......180.......190.......200-.......210.......220.......-230.......240........250.......260.......-270.......280.......290.......300.......310-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKR
K
I
I
M
DCDPGHD
D
A
I
A
L
I
L
AGAIDSP-
L
E
I
L
A
V
T
T
VAGNQSVDKNTTN
A
L
N
V
L
D
IMGRQDIAVAKGADRPLI
K
P
A
A
F
A
S
E
IHGESGLDGPKLPSTPSR-
Q
A
VAMP
A
S
D
V
I
I
N
K
VMTS-D-T-
P
V
T
I
V
ATGP
L
T
N
V
A
T
A
L
IRE
P
R
I
A
E
H
I
E
S
I
T
L
MGG--G-T-F-GNWTPT
A
E
F
N
I
W
V
D
A
E
A
A
K
R
V
F
ESG
I
T
I
N
V
F
GL
D
V
T
H
Q
V
L
AD
N
H
V
-
I
E
R
F
E
SIN
N
P
V
A
Q
F
V
V
E
L
L
Q
F
F
K
K
T
Y
K
-
T
HFNMDGGP
I
H
-
D
A
C
T
I
L
Y
L
LQPE
L
F
T
M
V
P
V
N
I
D
I
EHQSPL-
T
Y
G
T
M
A
V
D
LNHVTGKPAN
A
Y
F
A
T
AV
D
V
E
E
V
W
N
L
I
D
H
K
LRTYE--
21
PsiBlast_CBE
97.96
45%
-119
- C4 -
3G5I
2
RIHA_ECOLI
D:
[6-311]
----
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
--
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
--------
S
G
L
D
G
P
A
L
P
E
-
P
T
F
-
A
P
Q
N
C
T
A
V
E
L
M
A
K
T
L
R
E
S
-
A
-
E
-
P
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
--
A
-
M
G
L
-
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
Q
I
H
V
E
D
-
T
E
R
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
Y
H
K
D
E
K
W
G
F
V
G
A
P
L
H
-
D
P
C
T
I
A
W
L
L
K
P
E
L
F
T
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
-
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
---
2
PsiBlast_PDB
97.38
45%
-119
- C4 -
3G5I
3
RIHA_ECOLI
A:
[6-311]
----
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
--
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
I
A
D
N
V
H
G
E
S
G
L
D
G
P
A
L
P
E
-
P
T
F
-
A
P
Q
N
C
T
A
V
E
L
M
A
K
T
L
R
E
S
-
A
-
E
-
P
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
--
A
-
M
G
L
-
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
Q
I
H
V
E
D
-
T
E
R
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
-----
K
W
G
F
V
G
A
P
L
H
-
D
P
C
T
I
A
W
L
L
K
P
E
L
F
T
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
-
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
---
1
PsiBlast_PDB
96.69
45%
-119
- C4 -
1YOE
2
RIHA_ECOLI
A:
[16-321]
----
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
--
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
I
I
A
-----
E
S
G
L
D
G
P
A
L
P
E
-
P
T
F
-
A
P
Q
N
C
T
A
V
E
L
M
A
K
T
L
R
E
S
-
A
-
E
-
P
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
--
A
-
M
G
L
-
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
Q
I
H
V
E
D
-
T
E
R
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
F
L
E
-----
K
W
G
F
V
G
A
P
L
H
-
D
P
C
T
I
A
W
L
L
K
P
E
L
F
T
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
-
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
---
22
PsiBlast_CBE
96.42
45%
-123
- C4 -
3G5I
2
RIHA_ECOLI
C:
[6-311]
----
I
L
L
D
C
D
P
G
H
D
D
A
I
A
I
V
L
A
L
A
--
S
P
E
L
D
V
K
A
I
T
S
S
A
G
N
Q
T
P
E
K
T
L
R
N
V
L
R
M
L
T
L
L
N
R
T
D
I
P
V
A
G
G
A
V
K
P
L
M
R
E
L
----------
G
L
D
G
P
A
L
P
E
-
P
T
F
-
A
P
Q
N
C
T
A
V
E
L
M
A
K
T
L
R
E
S
-
A
-
E
-
P
V
T
I
V
S
T
G
P
Q
T
N
V
A
L
L
L
N
S
H
P
E
L
H
S
K
I
A
R
I
V
I
M
G
G
--
A
-
M
G
L
-
G
N
W
T
P
A
A
E
F
N
I
Y
V
D
P
E
A
A
E
I
V
F
Q
S
G
I
P
V
V
M
A
G
L
D
V
T
H
K
A
Q
I
H
V
E
D
-
T
E
R
F
R
A
I
G
N
P
V
S
T
I
V
A
E
L
L
D
F
-------
E
K
W
G
F
V
G
A
P
L
H
-
D
P
C
T
I
A
W
L
L
K
P
E
L
F
T
S
V
E
R
W
V
G
V
E
T
Q
G
K
Y
-
T
Q
G
M
T
V
V
D
Y
Y
Y
L
T
G
N
K
P
N
A
T
V
M
V
D
V
D
R
Q
G
F
V
D
L
L
A
D
R
L
K
F
Y
---
6
PsiBlast_PDB
94.83
40%
-113
- C4 -
1Q8F
7
RIHB_ECOLI
A:
[3-309]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
31
PsiBlast_CBE
94.63
40%
-111
- C4 -
1Q8F
7
RIHB_ECOLI
D:
[3-309]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
25
PsiBlast_CBE
94.37
40%
-113
- C4 -
3MKM
1
?
D:
[6-312]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
74
HHSearch
94.25
40%
-108
- C4 -
1Q8F
7
RIHB_ECOLI
A:
[3-310]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
A
--
K
H
P
A
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
E
I
-
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
-
E
P
L
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
--
A
-
Y
G
T
-
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
-
S
G
P
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
I
--
32
PsiBlast_CBE
94.25
40%
-114
- C4 -
1Q8F
6
RIHB_ECOLI
C:
[3-309]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
5
PsiBlast_PDB
94.11
40%
-112
- C4 -
3B9X
2
RIHB_ECOLI
A:
[23-329]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
3
PsiBlast_PDB
93.86
40%
-114
- C4 -
3MKM
1
?
A:
[6-312]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
33
PsiBlast_CBE
93.54
40%
-111
- C4 -
1Q8F
6
RIHB_ECOLI
B:
[3-309]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
84
Fugue
93.39
37%
-108
- C4 -
2MAS
2
IUNH_CRIFA
A:
[1-313]
-
A
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
-
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
N
-
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
-
E
-
P
K
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
-
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
G
K
L
-
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
DP
28
PsiBlast_CBE
93.15
40%
-118
* C4 *
3B9X
3
RIHB_ECOLI
D:
[23-329]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
--
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
73
HHSearch
93.05
38%
-108
- C4 -
2MAS
2
IUNH_CRIFA
A:
[1-311]
-
A
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
--
G
N
P
E
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
-
P
A
E
F
K
N
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
E
P
-
K
-
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
H
E
-
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
-
G
K
L
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
L
D
A
L
E
R
I
G
--
36
PsiBlast_CBE
92.53
37%
-111
- C4 -
2MAS
2
IUNH_CRIFA
B:
[2-303]
--
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
-
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
N
-
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
-
E
P
K
-
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
-
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
G
K
L
-
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
----------
8
PsiBlast_PDB
92.37
37%
-110
- C4 -
2MAS
2
IUNH_CRIFA
A:
[2-303]
--
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
-
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
N
-
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
-
E
P
K
-
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
-
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
G
K
L
-
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
----------
34
PsiBlast_CBE
92.16
37%
-111
- C4 -
2MAS
2
IUNH_CRIFA
D:
[2-303]
--
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
-
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
N
-
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
-
E
P
K
-
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
-
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
G
K
L
-
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
----------
30
PsiBlast_CBE
92.16
40%
-116
- C4 -
3B9X
2
RIHB_ECOLI
B:
[23-329]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
-----
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
N
Y
G
L
A
G
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
4
PsiBlast_PDB
91.96
40%
-121
- C4 -
3MKN
2
?
A:
[6-312]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
-------
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
35
PsiBlast_CBE
91.94
37%
-110
- C4 -
2MAS
2
IUNH_CRIFA
C:
[2-303]
--
K
K
I
I
L
D
C
D
P
G
L
D
D
A
V
A
I
L
L
A
H
G
-
N
P
E
-
I
E
L
L
A
I
T
T
V
V
G
N
Q
T
L
A
K
V
T
R
N
A
Q
L
V
A
D
I
A
G
I
T
G
V
P
I
A
A
G
C
D
K
P
L
V
R
K
I
M
T
A
G
H
I
H
G
E
S
G
M
G
T
V
A
Y
P
A
E
F
K
N
-
K
V
D
E
R
H
A
V
N
L
I
I
D
L
V
M
S
H
-
E
P
K
-
T
I
T
L
V
P
T
G
G
L
T
N
I
A
M
A
A
R
L
E
P
R
I
V
D
R
V
K
E
V
V
L
M
G
G
--
G
-
Y
-
H
E
G
N
A
T
S
V
A
E
F
N
I
I
I
D
P
E
A
A
H
I
V
F
N
E
S
W
Q
V
T
M
V
G
L
D
L
T
H
Q
A
L
A
T
P
P
I
-
L
Q
R
V
K
E
V
D
T
N
P
A
R
F
M
L
E
I
M
D
Y
Y
T
K
I
Y
Q
-
S
N
R
Y
M
A
A
A
A
V
H
-
D
P
C
A
V
A
Y
V
I
D
P
S
V
M
T
T
E
R
V
P
V
D
I
E
L
T
G
K
L
-
T
L
G
M
T
V
A
D
F
R
N
P
R
P
E
H
C
H
T
Q
V
A
V
K
L
D
F
E
K
F
W
G
L
V
----------
23
PsiBlast_CBE
91.77
40%
-117
- C4 -
3MKN
2
?
D:
[6-312]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
N
I
H
G
D
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
L
K
T
Q
F
-
E
------
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
24
PsiBlast_CBE
88.74
40%
-123
- C4 -
3MKN
2
?
C:
[6-312]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
D
-----
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
AY
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
I
M
N
F
T
-------------
G
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
29
PsiBlast_CBE
88.29
40%
-117
- C4 -
3B9X
3
RIHB_ECOLI
C:
[23-329]
-
K
R
K
I
I
L
D
C
D
P
G
H
D
D
A
I
A
I
M
M
A
-
A
K
H
P
A
-
I
D
L
L
G
I
T
I
V
A
G
N
Q
T
L
D
K
T
L
I
N
G
L
N
V
C
Q
K
L
-
E
I
N
V
P
V
Y
A
G
M
P
Q
P
I
M
R
Q
Q
I
V
A
------
T
G
L
D
G
P
V
F
E
P
L
-
T
R
-
Q
A
E
S
T
H
A
V
K
Y
I
I
D
T
L
M
A
S
-
D
-
G
-
D
I
T
L
V
P
V
G
P
L
S
N
I
A
V
A
M
R
M
Q
P
A
I
L
P
K
I
R
E
I
V
L
M
G
G
A
Y
G
-
T
---
G
N
F
T
P
S
A
E
F
N
I
F
A
D
P
E
A
A
R
V
V
F
T
S
G
V
P
L
V
M
M
G
L
D
L
T
N
Q
T
V
C
T
P
D
V
-
I
A
R
M
E
R
A
G
G
P
A
G
E
L
F
S
D
-------------------
P
V
H
-
D
A
T
C
I
G
Y
L
I
N
P
D
G
I
K
T
Q
E
M
Y
V
E
V
D
V
N
S
G
P
-
C
Y
G
R
T
V
C
D
E
L
G
V
L
G
K
P
A
N
T
K
V
G
I
T
I
D
T
D
W
F
W
G
L
V
E
E
C
V
R
G
Y
---
51
PsiBlast_CBE
71.73
33%
-89
- C4 -
3T8I
9
?
B:
[2-242]
--
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
S
R
F
----
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
P
E
-
P
N
K
-
R
P
E
K
E
H
A
I
D
A
I
L
R
L
S
K
E
H
-
E
-
G
-
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
--
A
F
S
-
K
-
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
-
T
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
---------------------------------------------------------------------
50
PsiBlast_CBE
71.37
33%
-89
- C4 -
3T8I
10
?
C:
[2-242]
--
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
S
R
F
----
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
P
E
-
P
N
K
-
R
P
E
K
E
H
A
I
D
A
I
L
R
L
S
K
E
H
-
E
-
G
-
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
--
A
F
S
-
K
-
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
-
T
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
---------------------------------------------------------------------
12
PsiBlast_PDB
71.34
33%
-88
- C4 -
3T8I
7
?
A:
[2-242]
--
R
K
V
I
V
D
S
D
T
A
T
D
D
T
I
A
I
L
L
A
S
R
F
----
F
Q
L
L
G
V
T
I
V
A
G
N
V
N
Y
N
Q
E
V
K
N
A
L
F
T
L
E
Y
I
G
K
Q
D
V
P
V
Y
L
G
S
Q
R
P
I
L
G
N
W
R
T
V
E
E
V
H
G
S
N
G
M
S
N
W
N
Y
P
E
-
P
N
K
-
R
P
E
K
E
H
A
I
D
A
I
L
R
L
S
K
E
H
-
E
-
G
-
E
L
E
I
L
A
I
S
P
L
T
N
I
A
L
A
Y
L
K
D
P
S
V
V
K
R
V
K
K
I
W
I
M
G
G
--
A
F
S
-
K
-
G
N
T
T
P
I
A
E
F
N
F
W
V
D
P
E
A
A
K
I
V
L
D
A
G
F
D
I
T
I
V
P
W
E
V
A
E
I
S
G
S
L
N
E
R
D
W
E
Y
I
S
K
L
N
T
K
L
S
N
F
F
I
N
V
N
K
T
L
K
E
-
Y
T
-
T
K
N
Q
G
I
S
G
S
I
H
P
D
S
L
T
V
---------------------------------------------------------------------