@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0342: (2016-03-14 )
MTRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEIDEVIIGNVLQAGQGQNPARIAAMKGGLPETVPAFTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQSPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGITAENLVEQYGISREEQDTFAVNSQHKAVRAQQNGEFDSEIVPVSIPQRKGEPILVTKDEGVRENVSVEKLSRLRPAFKKDGTVTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKALKRSKKELSDIDVFELNEAFAAQLLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLVTLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK
Atome Classification :
(23 SA)
.........10.....-...20.....----...30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.....--..-240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360....-.-.-.-370.......380........390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
R
V
V
L
A
AAYRTPIGV-FGGAFKDV
P
A
----
Y
D
L
G
A
T
L
I
E
H
I
I
K
ETGL
N
P
S
E
I
D
E
V
I
I
G
N
V
L
Q
AGQGQNP
A
R
I
A
A
MKGGLPETV
P
A
F
T
V
N
K
V
C
GS
G
L
K
S
I
Q
L
A
Y
Q
S
IVTGEN
D
I
V
L
AGGMENMSQS
P
M
L
VNNSRF
G
F
KMG
H
Q
S
M
V
D
S
M
V
Y
D
G
L
T
D
V
F
N
Q
YHMGI
T
A
E
N
L
V
E
Q
YGISREEQD
T
F
A
VNSQH
K
A
V
R
AQQNGEFDSEIVPVSIPQRKGE
P
I
L
V
TKDEGVRENV
S
V
E
K
L
S
R
L
R
P
A
F
K--KD-
G
T
V
TAGNASGINDG
A
A
M
M
L
V
MSEDKAKELNI
E
P
L
A
V
LDGFGSHGVDPSI
M
G
IA
P
V
G
A
V
E
K
A
L
K
R
S
K
K
ELSDI
D
V
F
E
L
N
E
A
F
A
A
Q
L
L
A
VDRELKLPP
E
K
V
NVKG
G
A
I
A
LGHPIGAS
G
A
R
V
L
V
T
L
L
H
Q
L-N-
D
-
E
-
V
E
T
G
L
T
S
L
CIGG-
G
Q
A
I
A
A
V
V
S
KYK
3
PsiBlast_PDB
97.42
56%
-82
- C5 -
4DD5
-
THLA_PEPD6
A:
[6-396]
M
R
E
V
V
I
A
S
A
A
R
T
A
V
G
S
-
F
G
G
A
F
K
S
V
S
A
----
V
E
L
G
V
T
A
A
K
E
A
I
K
R
A
N
I
T
P
D
M
I
D
E
S
L
L
G
G
V
L
T
A
G
L
G
Q
N
I
A
R
Q
I
A
L
G
A
G
I
P
V
E
K
P
A
M
T
I
N
I
V
C
G
S
G
L
R
S
V
S
M
A
S
Q
L
I
A
L
G
D
A
D
I
M
L
V
G
G
A
E
N
M
S
M
S
P
Y
L
V
P
S
A
R
Y
G
A
R
M
G
D
A
A
F
V
D
S
M
I
K
D
G
L
S
D
I
F
N
N
Y
H
M
G
I
T
A
E
N
I
A
E
Q
W
N
I
T
R
E
E
Q
D
E
L
A
L
A
S
Q
N
K
A
E
K
A
Q
A
E
G
K
F
D
E
E
I
V
P
V
V
I
K
----
D
T
V
-
V
D
K
D
E
Y
I
K
P
G
T
T
M
E
K
L
A
K
L
R
P
A
F
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
V
V
M
A
K
E
K
A
E
E
L
G
I
E
P
L
A
T
I
V
S
Y
G
T
A
G
V
D
P
K
I
M
G
Y
G
P
V
P
A
T
K
K
A
L
E
A
A
N
M
T
I
E
D
I
D
L
V
E
A
N
E
A
F
A
A
Q
S
V
A
V
I
R
D
L
N
I
D
M
N
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
C
S
G
A
R
I
L
T
T
L
L
Y
E
M
K
R
-
R
-
D
-
A
K
T
G
L
A
T
L
C
I
G
G
-
G
M
G
T
T
L
I
V
K
R
--
4
PsiBlast_PDB
95.75
55%
-83
- C5 -
4O99
1
THIL_CUPNH
A:
[1-391]
-
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
23
PsiBlast_CBE
95.55
58%
-87
- C5 -
4E1L
11
?
B:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
-
F
G
G
V
F
K
N
T
S
A
----
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
L
S
E
I
D
E
V
I
I
G
N
V
L
Q
T
G
L
G
Q
N
V
A
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
Y
I
V
P
T
A
R
F
G
S
K
M
G
---------
T
D
G
L
I
D
A
F
N
Q
Y
H
M
G
I
T
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
I
R
R
G
K
I
E
T
I
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
K
N
E
L
Q
I
D
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-
Q
-
K
R
K
-
V
E
T
G
L
A
T
L
C
I
G
G
-
G
Q
G
I
S
M
V
V
S
R
--
27
PsiBlast_CBE
95.54
55%
-83
- C5 -
4O9C
1
THIL_CUPNH
H:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
25
PsiBlast_CBE
95.50
55%
-81
- C5 -
4O99
1
THIL_CUPNH
C:
[1-391]
-
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
5
PsiBlast_PDB
95.37
55%
-82
- C5 -
4O9C
-
THIL_CUPNH
A:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
26
PsiBlast_CBE
95.28
55%
-81
- C5 -
4O99
1
THIL_CUPNH
B:
[1-391]
-
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
28
PsiBlast_CBE
94.90
55%
-81
- C5 -
4O9C
1
THIL_CUPNH
C:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
21
PsiBlast_CBE
94.63
58%
-85
- C5 -
4E1L
4
?
D:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
-
F
G
G
V
F
K
N
T
S
A
----
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
L
S
E
I
D
E
V
I
I
G
N
V
L
Q
T
G
L
G
Q
N
V
A
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
Y
I
-----------------------------
Q
Y
H
M
G
I
T
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
I
R
R
G
K
I
E
T
I
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
K
N
E
L
Q
I
D
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-
Q
-
K
R
K
-
V
E
T
G
L
A
T
L
C
I
G
G
-
G
Q
G
I
S
M
V
V
S
R
--
9
PsiBlast_PDB
94.45
50%
-84
- C5 -
2VU2
4
THIL_ZOORA
A:
[5-389]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
2
PsiBlast_PDB
94.42
56%
-80
- C5 -
4N45
-
?
A:
[1-391]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
-
Y
G
K
S
L
K
D
V
P
A
----
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
T
V
V
D
T
-
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
-
Q
-
K
R
D
-
A
K
K
G
L
A
T
L
S
I
G
G
-
G
Q
G
T
A
I
L
L
E
K
--
6
PsiBlast_PDB
94.36
54%
-81
- C5 -
4O9A
-
THIL_CUPNH
A:
[7-397]
-
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
-
F
G
G
S
L
A
K
I
P
A
----
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
-
K
R
R
-
D
-
A
K
K
G
L
A
S
L
C
I
G
G
-
G
M
G
V
A
L
A
V
E
R
--
126
HHSearch
94.12
50%
-82
* C5 *
2VU1
5
THIL_ZOORA
A:
[2-391]
T
P
S
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
-
G
D
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
E
S
--
34
PsiBlast_CBE
94.05
50%
-84
- C5 -
1DLU
4
THIL_ZOORA
B:
[2-386]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
31
PsiBlast_CBE
93.96
50%
-84
- C5 -
1DLV
5
THIL_ZOORA
B:
[2-386]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
37
PsiBlast_CBE
93.85
50%
-82
- C5 -
2VU2
5
THIL_ZOORA
B:
[5-389]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
20
PsiBlast_PDB
93.79
50%
-85
- C5 -
2VU0
4
THIL_ZOORA
A:
[5-389]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
22
PsiBlast_CBE
93.77
58%
-89
- C5 -
4E1L
3
?
C:
[4-395]
M
K
D
V
V
I
V
S
A
V
R
T
P
I
G
S
-
F
G
G
V
F
K
N
T
S
A
----
V
Q
L
G
T
I
A
V
K
E
A
I
S
R
V
G
L
N
L
S
E
I
D
E
V
I
I
G
N
V
L
Q
T
G
L
G
Q
N
V
A
R
Q
I
A
I
N
A
G
I
P
N
S
V
P
S
Y
T
V
N
K
L
C
G
S
G
L
K
S
V
Q
L
A
A
Q
S
I
T
S
G
E
N
D
V
V
I
A
G
G
T
E
N
M
S
Q
A
P
Y
I
V
P
----------------------------
Y
H
M
G
I
T
A
E
N
I
A
T
K
F
E
F
T
R
E
M
Q
D
K
L
A
L
E
S
Q
N
K
A
E
N
A
I
K
N
N
R
F
K
E
E
I
V
P
V
D
V
L
---
G
K
I
E
T
I
D
K
D
E
Y
P
K
L
G
M
T
F
E
G
L
S
K
L
K
P
A
F
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
I
L
M
S
Q
Q
K
A
D
E
L
G
I
R
P
L
A
K
I
K
S
Y
A
S
A
G
V
E
P
E
V
M
G
T
G
P
I
P
A
T
R
K
A
L
K
K
A
G
L
S
I
N
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
A
L
A
V
K
N
E
L
Q
I
D
S
S
K
L
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
I
Y
E
M
-
Q
-
K
R
K
-
V
E
T
G
L
A
T
L
C
I
G
G
-
G
Q
G
I
S
M
V
V
S
R
--
32
PsiBlast_CBE
93.74
50%
-82
- C5 -
1DLU
1
THIL_ZOORA
D:
[2-386]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
11
PsiBlast_PDB
93.70
50%
-82
- C5 -
2WKU
6
THIL_ZOORA
A:
[5-389]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
-
F
N
G
A
F
A
N
T
P
A
----
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
-
L
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
-
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
H
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
-
K
-
R
-
R
G
A
R
K
G
L
A
T
L
C
I
G
G
-
G
M
G
V
A
M
C
I
----
118
HHSearch
92.46
49%
-81
- C5 -
1WL4
7
THIC_HUMAN
A:
[6-396]
-
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
-
F
N
G
A
L
A
A
V
P
V
----
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
L
-
R
T
G
V
K
I
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
T
R
K
-
G
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
TD
G
T
-
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
-
E
-
R
-
M
G
R
S
R
G
V
A
-
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
--
82
PsiBlast_CBE
84.11
39%
-71
- C5 -
1AFW
2
THIK_YEAST
B:
[12-392]
---
V
V
I
V
A
A
N
R
S
A
I
G
K
G
F
K
G
A
F
K
D
V
N
T
D
Y
L
L
Y
N
F
L
N
E
F
I
G
R
F
P
E
P
L
R
A
D
L
N
L
I
E
E
V
A
C
G
N
V
L
N
V
G
A
G
A
T
E
H
R
A
A
C
L
A
S
G
I
P
Y
S
T
P
F
V
A
L
N
R
Q
C
S
S
G
L
T
A
V
N
D
I
A
N
K
I
K
V
G
Q
I
D
I
G
L
A
L
G
V
E
S
M
T
N
N
Y
K
N
V
N
--
P
L
G
M
I
S
S
E
E
L
Q
K
N
R
E
A
K
K
C
L
I
P
------
M
G
I
T
N
E
N
V
A
A
N
F
K
I
S
R
K
D
Q
D
E
F
A
A
N
S
Y
Q
K
A
Y
K
A
K
N
E
G
L
F
E
D
E
I
L
P
I
K
L
P
D
G
S
----
I
C
Q
S
D
E
G
P
R
P
N
V
T
A
E
S
L
S
S
I
R
P
A
F
I
--
K
D
R
G
T
T
T
A
G
N
A
S
Q
V
S
D
G
V
A
G
V
L
L
A
R
R
S
V
A
N
Q
L
N
L
P
V
L
G
R
Y
I
D
F
Q
T
V
G
V
P
P
E
I
M
G
V
G
P
A
Y
A
I
P
K
V
L
E
A
T
G
L
Q
V
Q
D
I
D
I
F
E
I
N
E
A
F
A
A
Q
A
L
Y
C
I
H
K
L
G
I
D
L
N
K
V
N
P
R
G
G
A
I
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
A
T
I
L
R
E
L
-
K
-
K
-
D
--
Q
I
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
I
F
I
K
--
83
PsiBlast_CBE
83.37
39%
-69
- C5 -
1AFW
2
THIK_YEAST
A:
[12-392]
---
V
V
I
V
A
A
N
R
S
A
I
G
K
G
F
K
G
A
F
K
D
V
N
T
D
Y
L
L
Y
N
F
L
N
E
F
I
G
R
F
P
E
P
L
R
A
D
L
N
L
I
E
E
V
A
C
G
N
V
L
N
V
G
A
G
A
T
E
H
R
A
A
C
L
A
S
G
I
P
Y
S
T
P
F
V
A
L
N
R
Q
C
S
S
G
L
T
A
V
N
D
I
A
N
K
I
K
V
G
Q
I
D
I
G
L
A
L
G
V
E
S
M
T
N
N
Y
K
N
V
N
--
P
L
G
M
I
S
S
E
E
L
Q
K
N
R
E
A
K
K
C
L
I
P
------
M
G
I
T
N
E
N
V
A
A
N
F
K
I
S
R
K
D
Q
D
E
F
A
A
N
S
Y
Q
K
A
Y
K
A
K
N
E
G
L
F
E
D
E
I
L
P
I
K
L
P
D
G
S
----
I
C
Q
S
D
E
G
P
R
P
N
V
T
A
E
S
L
S
S
I
R
P
A
F
I
-----
G
T
T
T
A
G
N
A
S
Q
V
S
D
G
V
A
G
V
L
L
A
R
R
S
V
A
N
Q
L
N
L
P
V
L
G
R
Y
I
D
F
Q
T
V
G
V
P
P
E
I
M
G
V
G
P
A
Y
A
I
P
K
V
L
E
A
T
G
L
Q
V
Q
D
I
D
I
F
E
I
N
E
A
F
A
A
Q
A
L
Y
C
I
H
K
L
G
I
D
L
N
K
V
N
P
R
G
G
A
I
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
A
T
I
L
R
E
L
-
K
-
K
-
D
--
Q
I
G
V
V
S
M
C
I
G
T
-
G
M
G
A
A
A
I
F
I
K
--