@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0346: (2016-03-14 )
MTLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKLARLEQGKFAFAFASGIAAISAVLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTVDTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKIAEKHELLVAVDNTFMTPLGQSPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISEALYLIQNGTGNMLSAQDSWTLAKHLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADESKAQQFVDALTLPLVSVSLGGVETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLEDPDELIADIKYALKEAFNESIPHTIER
Atome Classification :
(31 SA)
.........10....-....20........30.--.....--------..--------40-----.........50........60........70........80.....-.-...90........100.......110.......120.-......130.......140.......150...-....160.-..-....170.....-..180.......190.......-200........210......------.220------------------------..--.--......230.......240.......250.......260.......270.......-----280---..-----..------..-...290.......300..-......310.......320---.......330.......340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLSKE
T
E
V
I
F
D
WRR-GVEYHSANPPLYDSSTF--HQTSL--------GG--------
D
------
V
K
Y
D
YARSGNP
N
R
E
L
L
E
E
K
L
A
R
L
EQG
K
F
A
F
A
F
A
S
G
I
A
A
I
S
-
A
V
L
L
T
-F-KSG
D
H
V
ILPDDVYG
G
T
F
R
L
T
E
Q
I
L
N
RFN
I
E
F
T
TVD
T
T
-
K
L
E
Q
I
E
G
A
I
QSN
T
K
L
I
Y
I
ETPSNP
C
F
K
I
T
D
I
K
-
A
V
S
K
I
A
E
K-H
E
-
L
L
V
A
VDNTFMTP-LGQS
P
L
L
L
G
A
D
I
V
I
H
S
A
T
K
F
LS-GH-SD
L
I
A
G
A
V
ITN
N
E
A
I
S
E
------
A
L
--------------------------
Y
L
--I--QNGTGNMLSAQD
S
W
T
L
A
K
H
L
K
TF
P
I
R
F
K
Q
S
V
E
N
A
Q
K
I
V
S
F
L
IKQD
E
I
S
E
VYYPGL
T
-----
T
-----
A
H
-----
L
E
------QA-KNG
G
A
V
I
G
F
R
LA
D
E
-
S
K
A
-
Q
Q
F
V
D
A
L
T
L
P
L
V
S
VSLG
G
V
---
E
T
I
LSHPATMSHAAL
P
E
E
V
R
Q
ERG
I
T
F
G
L
F
R
L
SVGLE
D
P
D
E
L
I
A
D
I
K
Y
A
L
K
E
A
F
NESIPHTIER
23
PsiBlast_CBE
95.26
47%
-97
- C1 -
4L0O
1
METB_HELPY
K:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
R
--------
H
-------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
1
PsiBlast_PDB
95.21
47%
-97
- C1 -
4L0O
2
METB_HELPY
H:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
----------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
26
PsiBlast_CBE
92.50
47%
-98
- C1 -
4L0O
2
METB_HELPY
C:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
-----------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
H
P
N
Y
E
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
38
PsiBlast_CBE
91.48
39%
-92
- C1 -
1PG8
5
MEGL_PSEPU
C:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
EYGAACFA
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQY
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
28
PsiBlast_CBE
91.47
41%
-97
- C1 -
1IBJ
3
METC_ARATH
C:
[101-460]
-------------------
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
--
K
Q
P
S
A
--------
I
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
-
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
-
S
D
V
M
A
G
V
L
A
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
-----
D
HPGHH
L
H
-----
F
S
------
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
L
S
-
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
-------------
119
HHSearch
91.40
38%
-88
- C1 -
2RFV
1
?
A:
[9-397]
----
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
--
V
F
D
S
A
--------
E
Q
G
A
A
R
F-----------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
-
E
F
I
D
------
Q
A
--------------------------
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
HP
Q
Y
E
L
G
-----
Q
R
------
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
-
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
----------
37
PsiBlast_CBE
91.07
39%
-92
- C1 -
1PG8
4
MEGL_PSEPU
D:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
EYGAACFA
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQY
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
21
PsiBlast_CBE
90.87
47%
-97
- C1 -
4L0O
2
METB_HELPY
O:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
R
--------
H
------
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
25
PsiBlast_CBE
90.52
47%
-100
- C1 -
4L0O
2
METB_HELPY
E:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
39
PsiBlast_CBE
90.35
39%
-97
- C1 -
1PG8
6
MEGL_PSEPU
B:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
EYGAACFA
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQY
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
5
PsiBlast_PDB
90.32
41%
-99
- C1 -
4OMA
6
?
A:
[56-396]
-------------------------------------------------------------------
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
E
F
I
D
Q
------
A
R
--------------------------
F
V
G-
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
------
H
-----
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
-----------
6
PsiBlast_PDB
90.06
41%
-98
- C1 -
4HF8
5
?
A:
[56-396]
-------------------------------------------------------------------
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
E
F
I
D
Q
------
A
R
--------------------------
F
V
G-
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
------
H
-----
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
-----------
22
PsiBlast_CBE
89.98
47%
-100
- C1 -
4L0O
2
METB_HELPY
M:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
-----------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
24
PsiBlast_CBE
89.97
47%
-99
- C1 -
4L0O
1
METB_HELPY
G:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPNYE
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
27
PsiBlast_CBE
89.44
47%
-97
- C1 -
4L0O
2
METB_HELPY
A:
[24-378]
-------------------------
P
I
Y
Q
T
S
T
Y
--
R
Q
D
A
I
--------
G
R
--------
H
------
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
L
-
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
-
S
D
V
V
A
G
L
V
T
T
N
N
E
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
-----
T
HPN
Y
E
L
A
-----
K
K
------
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
E
A
-
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
----------------
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
------------
18
PsiBlast_PDB
89.42
39%
-93
- C1 -
1PG8
6
MEGL_PSEPU
A:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
E
Y
G
A
A
C
F
A
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQ
Y
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
10
PsiBlast_PDB
89.24
41%
-96
- C1 -
3JWB
4
?
A:
[56-396]
-------------------------------------------------------------------
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
E
F
I
D
Q
------
A
R
--------------------------
F
V
G-
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
------
H
-----
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
-----------
43
PsiBlast_CBE
89.22
38%
-95
- C1 -
1UKJ
2
MEGL_PSEPU
D:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
EYGAACFA
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQY
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
51
PsiBlast_CBE
89.21
38%
-96
- C1 -
3VK3
1
MEGL_PSEPU
C:
[30-395]
------------------------
P
P
V
Y
Q
T
A
T
F
--
T
F
P
T
V
EYGAACFA
G
E
--------
Q
------
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
-
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
H
T
F
A
F
L
H
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
-
G
V
A
K
I
A
R
K
-
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
-
G
D
I
T
A
G
-
I
V
V
G
S
Q
A
L
V
D
------
R
I
--------------------------
R
L
QG
L
--
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
SFPQY
T
-----
L
A
-----
R
Q
------
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
-
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
---
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
-------------
8
PsiBlast_PDB
89.20
41%
-97
- C1 -
3JW9
2
?
A:
[56-396]
-------------------------------------------------------------------
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
E
F
I
D
Q
------
A
R
--------------------------
F
V
G-
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
------
H
-----
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
-----------
2
PsiBlast_PDB
88.72
41%
-93
- C1 -
1IBJ
4
METC_ARATH
A:
[101-460]
-------------------
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
--
K
Q
P
S
A
--------
I
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
-
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
-
S
D
V
M
A
G
V
L
A
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
-----
D
HPG
H
H
L
H
-----
F
S
------
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
L
S
-
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
-------------
9
PsiBlast_PDB
87.98
41%
-96
- C1 -
3JWA
6
?
A:
[56-396]
-------------------------------------------------------------------
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
-
G
D
V
I
G
G
I
I
V
G
K
Q
E
F
I
D
Q
------
A
R
--------------------------
F
V
G-
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
-----
S
------
H
-----
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
-----------
16
PsiBlast_PDB
86.93
38%
-92
- C1 -
1E5E
5
?
A:
[21-392]
------------------
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
--------
N
R
F
A
GQ
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
I
C
G
K
A
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G-
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
-----
D
-----
H
E
G
H
D
I
A
K
K
------
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
-
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
--------------
17
PsiBlast_PDB
86.28
38%
-93
- C1 -
1E5F
6
?
A:
[21-392]
------------------
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
--------
G
G
--------
N
R
F
A
GQ
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
I
C
G
K
A
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G-
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
-----
D
-----
H
E
G
H
D
I
A
K
K
------
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
-
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
--------------
36
PsiBlast_CBE
85.67
38%
-94
- C1 -
1E5E
6
?
B:
[21-392]
------------------
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
VF
D
N
C
Q
Q
--------
G
G
--------
N
RFAGQE
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
I
C
G
K
A
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G-
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
-----
D
-----
H
E
GHDIA
K
K
------
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
-
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
--------------
35
PsiBlast_CBE
85.21
38%
-94
- C1 -
1E5F
5
?
B:
[21-392]
------------------
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
VF
D
N
C
Q
Q
--------
G
G
--------
N
RFAGQE
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
I
C
G
K
A
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G-
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
-----
D
-----
H
E
GHDIA
K
K
------
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
-
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
--------------
113
HHSearch
84.29
37%
-84
- C1 -
1E5E
5
?
A:
[7-397]
---
T
P
A
T
A
C
I
H
A
N
P
Q
-
K
D
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
S
Q
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
-
D
V
V
-
A
G
L
I
C
G
K
A
-
D
L
L
Q
------
Q
I
--------------------------
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
-----
D
HEG
H
D
I
A
-----
K
K
------
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
-
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
---------
114
HHSearch
84.12
39%
-85
- C1 -
1IBJ
4
METC_ARATH
A:
[86-460]
---
S
V
S
T
L
L
V
N
L
D
N
K
-
F
D
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
--
K
Q
P
S
A
--------
I
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
-
H
L
-
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
S
D
V
M
-
A
G
V
L
A
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
-----
D
HPG
H
H
L
H
-----
F
S
------
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
L
S
-
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
----
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
---------
84
PsiBlast_CBE
83.24
40%
-103
- C1 -
1PFF
17
?
A:
[3-327]
--------------------------------------------------------------------------------
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
-
A
S
V
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
-
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
-
G
H
-
T
D
V
V
A
G
L
V
C
S
R
A
D
I
I
A
K
------
V
K
--------------------------
S
Q
G-
I
--
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
-----
D
HP---
G
H
E
I
A
--
K
K
------
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
D
G
L
-
E
K
A
-
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
--------------
121
HHSearch
77.53
30%
-80
- C1 -
2CTZ
1
?
A:
[3-421]
----
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
L
S
R
Q
V
P
I
Y
P
T
T
S
Y
--
V
F
K
S
P
--------
E
H
A
A
N
L
F
A
LK
E
------
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
-
A
-
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
-
A
L
A
Q
A
A
R
E
-
K
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
-
G
H
-
G
A
V
I
A
G
A
I
V
D
G
G
-
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
--
G
--
L
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
-----
H
HPH
H
D
R
A
-----
Q
K
------
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
K
G
G
Y
E
A
A
-
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
---
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
-------------
125
HHSearch
76.96
38%
-98
* C1 *
1PFF
18
?
A:
[2-330]
-------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
-
L
-
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
V
E
V
D
F
I
D
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A
-
V
P
G
N
I
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K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
-
D
A
V
K
Q
A
R
K
Q
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
-
D
V
V
A
-
G
L
V
C
S
R
A
-
D
I
I
A
------
K
V
--------------------------
K
S
--
Q
GI
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
-----
D
HPG
H
E
I
A
-----
K
K
------
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
D
G
L
-----
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
-----------