@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0419: (2016-03-15 )
MNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTANPTRSSVESVIAALENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYGGTYRALTKVFTRFGIEVDFVDTTHTDSIVQAIRPTTKMLFIETPSNPLLRVTDIKKSAEIAKEHGLISVVDNTFMTPYYQNPLDLGIDIVLHSATKYLGGHSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLVRGIKTLGLRMEQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAFEVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKEGITDGLVRISVGIEDTEDLVDDLKQALDTL
Atome Classification :
(36 SA)
.........10........-20........30...--..--...-------40----..-.......50........60........70........80....-.....90........100.......110-.......120.-......130.......140.......150.......160..-..-....170.......-180.......190.......200.....-..210..-....------.220------------------------..--..--.....230.......240.......250.......260.......270.......280.......290........300.-..-....310.......320.......---330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKK
T
K
L
I
HGGHTTDDYTG-
A
V
TT
P
I
Y
QT
S
T
Y
L
Q
D
--
D
I
--
G
D
L
-------
R
-----QG-YEYSRTANP
T
R
S
S
V
E
S
V
I
A
A
L
ENGKHGFAFS
S
G
V
A
A
I
S
-
A
V
V
M
-
L
LDKG
D
H
I
I
LNSDVYG
G
T
Y
R
A
L
T
K
V
F
T
R-FG
I
E
V
D
F
VDTT-H
T
D
S
I
V
Q
A
IRPT
T
K
M
L
F
I
ETPSN
P
L
L
R
V
T
D
I
K
K
S
A
E
I
A
-
K
E-HG-
L
I
S
VVDNTFMTPYY-QN
P
L
D
L
G
I
D
I
V
L
H
S
A
T
K
YLGG
H
S
D
V
V
A
G
-LVAT
S
D
D
-
K
L
A
E
------
R
L
--------------------------
A
F
--
I
S--NSTGGILGPQDS
Y
L
L
V
R
G
I
K
T
L
G
L
R
M
E
Q
I
N
R
S
V
I
E
I
I
K
M
L
Q
A
H
P
A
V
Q
Q
V
F
H
P
S
I
E
S
HLNHD
V
H
M
A
QA-DGH
T
G
V
I
A
F
E
VK-N
T
-
E
S
A
K
Q
L
I
K
AT
S
Y
Y
T
L
A
E
S
L
G
A
V
E
S
---
L
I
S
V
P
A
L
M
THASIPADIRAKEGITD
G
L
V
R
I
S
VGIE
D
T
E
D
L
V
D
D
L
K
Q
A
L
DTL
30
PsiBlast_CBE
91.02
50%
-99
- C1 -
4IY7
6
?
B:
[19-393]
----
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
--
S
P
--
G
E
--------
H
-----
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
---
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
28
PsiBlast_CBE
90.93
50%
-98
- C1 -
4IY7
5
?
D:
[19-393]
----
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
--
S
P
--
G
E
--------
H
-----
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
---
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
29
PsiBlast_CBE
90.57
50%
-100
- C1 -
4IY7
4
?
C:
[19-393]
----
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
--
S
P
--
G
E
--------
H
-----
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
---
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
3
PsiBlast_PDB
89.71
50%
-98
- C1 -
4IYO
8
?
A:
[19-393]
----
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
--
S
P
--
G
E
--------
H
-----
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
---
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
1
PsiBlast_PDB
89.14
54%
-101
- C1 -
4L0O
2
METB_HELPY
H:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
-----------------------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
2
PsiBlast_PDB
88.76
50%
-96
- C1 -
4IY7
8
?
A:
[19-393]
----
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
-
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
--
S
P
--
G
E
--------
H
-----
Q
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
-
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
---
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
26
PsiBlast_CBE
88.02
54%
-100
- C1 -
4L0O
2
METB_HELPY
C:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
----------------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
23
PsiBlast_CBE
87.51
54%
-97
- C1 -
4L0O
1
METB_HELPY
K:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
R
--------
H
------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
25
PsiBlast_CBE
87.32
54%
-102
- C1 -
4L0O
2
METB_HELPY
E:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
21
PsiBlast_CBE
87.18
54%
-99
- C1 -
4L0O
2
METB_HELPY
O:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
R
--------
H
-----
K
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
24
PsiBlast_CBE
86.83
54%
-100
- C1 -
4L0O
1
METB_HELPY
G:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
36
PsiBlast_CBE
86.37
45%
-98
- C1 -
3COG
8
CGL_HUMAN
C:
[21-395]
----
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
--
A
P
--
G
Q
---------------
G
-
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
-
L
V
S
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
---
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
---
39
PsiBlast_CBE
85.83
45%
-100
- C1 -
2NMP
2
CGL_HUMAN
C:
[21-395]
----
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
--
A
P
--
G
Q
---------------
G
-
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
-
L
V
S
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
---
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
---
22
PsiBlast_CBE
85.81
54%
-102
- C1 -
4L0O
2
METB_HELPY
M:
[1-376]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
T
T
G
-
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
--
A
I
--
G
----------------
G
-
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
G
-
L
V
T
T
N
N
E
-
A
L
A
Q
------
E
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
K
-
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
---
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
---
38
PsiBlast_CBE
85.33
45%
-99
- C1 -
2NMP
2
CGL_HUMAN
D:
[21-395]
----
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
--
A
P
--
G
Q
--------
H
-----
S
G
-
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
-
L
V
S
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
---
L
A
E
L
P
A
I
M
T
H
A
S
--
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
---
106
HHSearch
84.07
42%
-99
- C1 -
2RFV
1
?
A:
[8-396]
-
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
--
S
A
--
E
Q
G
A
A
R
F----------
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
-
D
V
I
G
G
I
I
V
G
K
Q
--
E
F
I
D
------
Q
A
--------------------------
R
F
VG
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
-
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
18
PsiBlast_PDB
83.78
45%
-103
- C1 -
2NMP
1
CGL_HUMAN
A:
[21-395]
----
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
--------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
-
L
V
S
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
---
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
---
35
PsiBlast_CBE
83.73
45%
-97
- C1 -
3COG
9
CGL_HUMAN
D:
[21-395]
----
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
--
A
P
--
G
Q
--------
H
-----
S
G
-
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
G
-
L
V
S
V
N
C
E
-
S
L
H
N
------
R
L
--------------------------
R
F
--
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
-
T
G
C
T
G
M
V
T
F
Y
I
K
-
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
---
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
---
15
PsiBlast_PDB
83.54
41%
-98
- C1 -
2RFV
1
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F-----
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
12
PsiBlast_PDB
83.20
41%
-98
- C1 -
3JW9
2
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
14
PsiBlast_PDB
82.41
41%
-97
- C1 -
3JWB
4
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
9
PsiBlast_PDB
82.09
41%
-99
- C1 -
4OMA
6
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
13
PsiBlast_PDB
81.89
41%
-97
- C1 -
3JWA
6
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
10
PsiBlast_PDB
80.76
41%
-97
- C1 -
4HF8
5
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F
A
LE
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
11
PsiBlast_PDB
79.07
41%
-101
- C1 -
3MKJ
1
?
A:
[10-393]
---
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
-
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--
G
A
A
-------
R
F------------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
-
I
I
V
G
K
Q
E
-
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
---
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
---
42
PsiBlast_CBE
79.00
41%
-96
- C1 -
1E5E
6
?
B:
[6-395]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
F
-
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
--
N
C
QQ
G
G
N
-------
R
FAGQE
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
I
C
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
105
HHSearch
78.04
41%
-93
- C1 -
1E5E
5
?
A:
[7-395]
-
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
-
Q
F
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
--
N
C
--
Q
Q
G
G
N
R
F
A
GQ
E
-----
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
Q
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
I
C
G
K
A
--
D
L
L
Q
------
Q
I
--------------------------
R
M
--
V
G
IK
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
41
PsiBlast_CBE
78.04
41%
-94
- C1 -
1E5F
6
?
A:
[6-395]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
F
-
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
--
N
C
Q
Q
G
G
N
-------
R
F
A
GQ
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
I
C
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
40
PsiBlast_CBE
78.04
41%
-93
- C1 -
1E5F
5
?
B:
[6-395]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
F
-
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
--
N
C
QQ
G
G
N
-------
R
FAGQE
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
I
C
G
K
A
D
-
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
104
HHSearch
77.17
42%
-94
- C1 -
1IBJ
4
METC_ARATH
A:
[85-462]
A
S
V
S
T
L
L
V
N
L
D
N
K
F
D
-
P
F
D
-
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
--
S
A
--
I
E
--------
N
-----
G
P
-
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
-
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
-
V
L
A
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
---
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
20
PsiBlast_PDB
77.11
41%
-94
- C1 -
1E5E
5
?
A:
[6-395]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
Q
F
-
G
-
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
--
N
C
Q
Q
G
G
N
-------
R
F
A
GQ
E
S
G
-
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
-
E
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
I
C
G
K
A
D
-
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
K
-
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
7
PsiBlast_PDB
76.94
43%
-101
- C1 -
1IBJ
4
METC_ARATH
A:
[103-462]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
--
S
A
----
I
-------
E
-----
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
-
V
L
A
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
---
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
97
PsiBlast_CBE
76.63
41%
-108
- C1 -
1PFF
18
?
A:
[1-328]
-----------------------------------------------------------------------
S
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
-
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
-
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
V
C
S
R
A
D
-
I
I
A
K
V
-----
K
S
--------------------------
Q
G
--
I
K
--
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
D
-
G
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
---
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
--
31
PsiBlast_CBE
76.36
43%
-100
- C1 -
1IBJ
3
METC_ARATH
C:
[103-462]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
--
S
A
----
I
-------
E
-----
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
-
V
L
A
V
K
G
E
-
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
G
-
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
---
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
115
HHSearch
74.10
38%
-107
- C1 -
1PFF
18
?
A:
[2-330]
------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
-
R
K
Q
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
-
L
V
C
S
R
A
--
D
I
I
A
------
K
V
--------------------------
K
S
--
Q
G
IK
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
D
-
G
L
----
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
110
HHSearch
66.44
32%
-89
- C1 -
2CTZ
1
?
A:
[1-421]
M
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
T
T
L
-
S
R
Q
V
P
I
Y
P
T
T
S
Y
V
F
K
--
S
P
--
E
H
A
A
N
L
F
A
LK
E
-----
F
G
-
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
-
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
-
L
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
-
R
E
-
K
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
-
A
V
I
A
-
G
A
I
V
D
G
G
-
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
--
G
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
K
-
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
---
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--