@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0420: (2016-03-15 )
MIEFRQVSKSFHKKKQTIDALKDVSFTVNRNDIFGVIGYSGAGKSTLVRLVNHLEAASNGQVIVDGHDITNYSEKGMREIKKDIGMIFQHFNLLNSATVFKNVAMPLILSKKSKTEIKQRVTEMLEFVGLSDKKDQFPDELSGGQKQRVAIARALVTNPKILLCDEATSALDPATTASILTLLKNVNQTFGITIMMITHEMRVIKDICNRVAVMEKGQVVETGTVKEVFSHPKTTIAQNFVSTVIQTEPSTSLIRRLNDEQVGGFKDYKIFVEETQVTQPIINDLIQICGREVKILFSSMSEIQGNTVCYMWLRFNIDQQFDDTAINQYFKEKNIQFEEVH
Atome Classification :
(61 SA)
-.........10......-..20........30........40........50........60........-70...----------..----------...80..-......90-........100.-..-....110-........120.......-130-..-.-...----..140--.........150.......160.......170.......180.......190.......200.......210.......220.......230.......240..------------.....250.......260........270....---...280.......290........300.....-..310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MI
E
F
R
Q
V
S
K
S
F
H
K
K
K
Q
T
-
I
D
A
LKD
V
S
F
T
VNRN
D
I
F
G
V
IGYSGA
G
K
S
T
L
V
R
L
V
N
H
L
E
AASN
G
Q
V
I
V
DGHDI-TN
Y
S
E
----------
K
G
----------
M
R
E
I
K
K
D
-
I
G
M
I
F
Q
H
F
-
N
LL
N
S
A
T
V
F
K
NV-AM-
P
L
I
LS-K-K
S
K
T
E
I
K
Q
R
V
T
E
M
L
E
F
VG-LS--DK-K-DQF----
P
D
E----LSGG
Q
K
Q
R
V
A
I
A
R
A
LVTNP
K
I
L
L
CDEATSALDP
A
T
T
A
S
I
L
T
L
L
K
NVNQTF
G
I
T
I
M
M
I
T
H
E
M
R
V
I
K
D
I
C
N
R
V
A
VMEKG
Q
V
VETG
T
V
K
E
V
FSHP
K
T
T
I
A
Q
N
F
V
S
T
V
------------IQTEP
S
T
S
L
I
R
R
L
N
D
E
-QVGGFK
D
Y
K
I
F
V
EETQ---V
T
Q
P
I
I
N
D
L
I
Q
I
C
G
R
-
E
V
K
I
L
F
S
S
M
S
EIQGN
T
-
V
C
Y
M
W
L
R
FNIDQQF
D
D
T
A
I
N
Q
Y
F
K
EKN
I
Q
FEEVH
119
HHSearch
95.36
46%
-120
- C1 -
3TUI
1
METN_ECOLI
C:
[24-364]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
---
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
-
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
-
F
G
I
M
L
T
E
M
H
G
T
Q
-
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
110
Fugue
92.98
46%
-122
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
---
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
-
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
-
F
G
I
M
L
T
E
M
H
-
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
--
3
PsiBlast_PDB
86.08
48%
-114
- C1 -
3TUZ
3
METN_ECOLI
C:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
22
PsiBlast_CBE
85.51
48%
-108
- C1 -
3TUZ
3
METN_ECOLI
G:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
25
PsiBlast_CBE
85.31
48%
-110
- C1 -
3TUI
1
METN_ECOLI
G:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
23
PsiBlast_CBE
85.26
48%
-109
- C1 -
3TUZ
3
METN_ECOLI
D:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
2
PsiBlast_PDB
85.04
48%
-111
- C1 -
3TUI
1
METN_ECOLI
C:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
21
PsiBlast_CBE
84.20
48%
-114
- C1 -
3TUZ
3
METN_ECOLI
H:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
24
PsiBlast_CBE
84.05
48%
-116
- C1 -
3TUI
1
METN_ECOLI
H:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
26
PsiBlast_CBE
83.56
48%
-109
- C1 -
3TUI
1
METN_ECOLI
D:
[24-354]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
1
PsiBlast_PDB
78.95
49%
-109
- C1 -
3DHW
-
METN_ECOLI
C:
[1-331]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
-
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
----------
S
E
----------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
-
H
-
D
S
Y
----
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
LHLDIPEDYQER
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
RFN
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
---------------------------
15
PsiBlast_PDB
69.54
37%
-116
- C1 -
2OUK
1
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
68.77
38%
-103
- C1 -
4U02
1
?
D:
[8-243]
---------
R
N
L
H
K
W
F
G
P
-
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
-
K
D
--
D
----------
R
A
----------
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
-
I
L
--
D
Q
-
A
-
R
K
Y
----
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
------------
L
H
-----------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.54
38%
-99
- C1 -
4U02
1
?
B:
[8-243]
---------
R
N
L
H
K
W
F
G
P
-
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
-
K
D
--
D
----------
R
A
----------
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
-
I
L
--
D
Q
-
A
-
R
K
Y
----
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
------------
L
H
-----------------------------------------------------------------------------------------------------
137
HHSearch
68.12
36%
-114
- C1 -
1B0U
4
HISP_SALTY
A:
[7-253]
--
L
H
V
I
D
L
H
K
R
Y
G
G
-----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
-
N
L
V
R
D
KDGQLKVAD
K
N
Q
----------
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
-
N
L
W
S
H
M
T
V
L
E
N
V
-
M
E
-
A
P
I
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
-
I
D
--
E
R
-
A
Q
G
K
Y
----
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.02
39%
-114
- C1 -
4YMW
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.84
37%
-116
- C1 -
3C4J
4
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.71
37%
-110
- C1 -
2OLK
1
?
D:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.53
37%
-111
- C1 -
2OLK
1
?
C:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.48
39%
-114
- C1 -
4YMS
-
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.32
37%
-111
- C1 -
3C41
3
?
K:
[3-241]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.17
37%
-108
- C1 -
2OLK
2
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.05
39%
-111
- C1 -
4YMV
1
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.86
37%
-108
- C1 -
3C41
3
?
J:
[3-241]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
66.85
39%
-113
- C1 -
4YMU
2
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.67
37%
-108
- C1 -
2OLK
1
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.44
38%
-101
- C1 -
4U00
3
?
A:
[8-243]
---------
R
N
L
H
K
W
F
G
P
-
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
-
K
D
--
D
----------
R
A
----------
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
-
I
L
--
D
Q
-
A
-
R
K
Y
----
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
------------
L
H
-----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.33
37%
-113
- C1 -
2OLJ
4
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
66.11
35%
-110
- C1 -
1B0U
4
HISP_SALTY
A:
[12-253]
-----------
L
H
K
R
Y
G
G
-
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
-
N
L
V
R
D
----------
K
D
GQLKVAD
K
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
-
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
L
-
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
-
I
D
--
E
R
A
Q
-
G
K
Y
----
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
----------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.63
39%
-111
- C1 -
4YMV
1
?
A:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.34
39%
-113
- C1 -
4YMU
2
?
J:
[1-240]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
-
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
-
N
N
-
G
K
----------
V
N
----------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
--
D
K
-
K
-
D
Q
Y
----
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
------------
L
------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
64.88
37%
-109
- C1 -
2Q0H
4
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.42
37%
-105
- C1 -
2Q0H
4
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.28
37%
-108
- C1 -
2OLJ
3
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
135
HHSearch
64.04
37%
-111
* C1 *
2OLJ
4
?
A:
[24-258]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
-----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
-----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
-
A
P
M
K
V
-
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
-----------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.38
37%
-106
- C1 -
3C4J
3
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
----
G
S
-
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
K
D
----------
T
N
----------
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
--
D
K
-
A
-
H
A
Y
----
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.79
34%
-108
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-226]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
-
K
G
Y
--------------------------
E
I
R
R
N
-
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
D
E
V
-
A
F
-
A
V
K
N
F
-
Y
-
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
-
K
-
D
R
V
----
P
F
F
----
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.01
34%
-108
- C1 -
4HLU
3
ECFA2_THEMA
B:
[5-226]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
-
K
G
Y
--------------------------
E
I
R
R
N
-
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
D
E
V
-
A
F
-
A
V
K
N
F
-
Y
-
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
-
K
-
D
R
V
----
P
F
F
----
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
58.46
33%
-100
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
58.31
33%
-101
- C1 -
1XEF
3
D:
[2-230]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
124
HHSearch
57.86
30%
-97
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-245]
-
A
L
H
I
G
H
L
S
K
S
F
Q
N
-----
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
-
F
S
K
N
-----------
T
N
----------
L
P
V
R
E
R
R
-
L
G
Y
L
V
Q
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
G
N
G
-
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
--
E
L
-
A
-
G
R
Y
----
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
---------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
57.35
33%
-103
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[2-230]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.06
33%
-99
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[2-230]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
56.89
33%
-96
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
56.75
33%
-97
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[2-230]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
56.62
33%
-98
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.61
33%
-115
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
-
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
-
N
D
L
D
D
----------
D
E
----------
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
-
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
-
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
-
M
A
--
E
L
-
E
-
E
R
F
ANHK
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
56.24
33%
-99
- C1 -
2FGJ
2
D:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
56.23
31%
-94
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[9-243]
------
H
L
S
K
S
F
----
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
----------
L
P
----------
V
R
E
--
R
R
-
L
G
Y
L
V
Q
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
G
N
G
-
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
--
E
L
-
A
-
G
R
Y
----
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
------------
I
------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
56.05
33%
-97
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
55.58
33%
-98
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
55.17
34%
-93
- C1 -
2FF7
1
A:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
54.98
33%
-96
- C1 -
2FGK
2
D:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
54.68
33%
-97
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.55
34%
-98
- C1 -
2PMK
1
A:
[4-232]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
54.16
31%
-94
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[9-248]
------
H
L
S
K
S
F
----
Q
N
-
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
----------
L
P
----------
V
R
E
--
R
R
-
L
G
Y
L
V
Q
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
-
G
L
G
N
G
-
K
-
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
--
E
L
-
A
-
G
R
Y
----
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
------------
I
------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
54.13
31%
-114
- C1 -
1VCI
1
?
A:
[27-251]
---------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
-
T
Y
L
P
P
----------
K
---------------
D
R
N
-
I
S
M
V
F
Q
-------
H
M
T
V
Y
E
N
I
-
A
F
-
P
L
--
K
-
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
-
I
E
--
E
L
-
L
-
N
R
Y
----
P
A
Q
----
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
--------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
53.87
34%
-105
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[4-225]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
---
K
G
Y
--------------------------
E
I
R
R
N
-
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
D
E
V
-
A
F
-
A
V
K
N
F
-
Y
-
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
-
K
-
D
R
V
----
P
F
F
----
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
53.68
33%
-91
- C1 -
2FFA
2
A:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
53.36
33%
-90
- C1 -
2FFB
1
A:
[8-236]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QG
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.28
33%
-92
- C1 -
3B5J
1
A:
[4-232]
--
I
T
F
R
N
I
R
--
F
R
Y
K
P
D
S
-
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
-
A
L
A
D
P
----------
N
W
----------
L
R
---
R
Q
-
V
G
V
V
L
Q
D
N
-
V
L
L
N
R
-
S
I
I
D
N
I
-
S
L
-
A
N
P
G
M
-
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
--
E
G
-
Y
-
N
T
I
----
V
G
E
QG
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-----------------------------------------------------------------------------------------------------------------------------