@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0458: (2016-03-15 )
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLFD
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......-110....----....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.-...-..-.290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLNNEYKNS
S
L
K
I
F
S
LKG
N
E
A
L
A
Q
E
V
A
D
Q
VGIELGK
C
S
V
K
RFSDG
E
I
Q
I
N
I
E
ESIRG
C
D
V
F
I
I
QPTSYP
V
N
L
H
L
M
E
L
L
I
M
I
D
A
C
KRAS
A
A
T
I
N
I
V
VPYYGYARQDRKAR-S-REP
I
T
----
A
K
L
V
A
N
L
I
E
TAGA
T
R
M
I
A
L
D
LHAPQI
Q
G
F
F
DI
P
I
D
H
LMG
V
P
I
L
A
K
HFKDDPNI
N
P
E
E
C
V
V
VSPDHG
G
V
T
R
A
R
K
L
A
D
I
L
K
T
P
I
A
I
IDKRRPRP
N
V
A
E
V
M
N
I
V
G
EIEG
R
T
A
I
I
I
D
D
IIDTA
G
T
I
T
L
A
A
Q
A
L
K
DK
G
A
K
E
V
Y
A
C
CTHPVLSG
P
A
K
E
R
I
E
N
S
A
I
K
E
L
IVTN
S
I
-HLD-ED-RKPSNT
K
E
L
S
V
A
G
L
I
A
Q
A
I
I
R
V
Y
ERE
S
V
S
V
LFD
22
PsiBlast_CBE
98.28
76%
-159
- C9 -
1DKR
3
KPRS_BACSU
B:
[2-316]
--
S
N
Q
Y
G
D
K
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
----
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
---
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
-
K
L
P
-
E
E
-
K
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
21
PsiBlast_CBE
97.69
76%
-162
- C9 -
1DKU
3
KPRS_BACSU
B:
[9-316]
---------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
----
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
---
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
-
K
L
------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
64
HHSearch
96.69
77%
-160
- C9 -
1DKU
3
KPRS_BACSU
A:
[9-316]
---------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
----
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
---
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
-
K
L
------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
82
Fugue
96.67
78%
-157
- C9 -
1DKU
3
KPRS_BACSU
A:
[9-316]
---------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
----
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
---
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
------
K
-
L
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
1
PsiBlast_PDB
96.64
76%
-160
- C9 -
1DKU
3
KPRS_BACSU
A:
[9-316]
---------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
-
R
E
P
I
T
----
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
---
N
L
E
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
P
I
A
I
I
D
K
R
---------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
-
K
L
------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
-
23
PsiBlast_CBE
89.25
54%
-144
- C9 -
3DAH
5
?
C:
[7-313]
---------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
----
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
---
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
I
D
K
R
R
-------
V
M
N
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
-
P
L
S
A
E
S
-
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
----
24
PsiBlast_CBE
86.97
54%
-142
- C9 -
3DAH
7
?
B:
[6-316]
--------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
----
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
---
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
-----------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
-
P
L
S
A
E
S
-
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
-
4
PsiBlast_PDB
85.75
45%
-148
- C9 -
4LYG
2
PRPS1_HUMAN
A:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
34
PsiBlast_CBE
85.47
45%
-146
- C9 -
4M0P
3
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
T
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
28
PsiBlast_CBE
85.35
45%
-146
- C9 -
4LZN
3
PRPS1_HUMAN
A:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
63
HHSearch
85.18
54%
-141
- C9 -
3DAH
4
?
A:
[6-315]
--------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
-
R
V
A
I
S
----
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
---
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
-
P
L
S
-
A
E
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
--
2
PsiBlast_PDB
85.03
54%
-140
- C9 -
3DAH
4
?
A:
[6-315]
--------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
-
S
A
R
V
A
I
S
----
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
---
N
Y
P
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
C
D
L
A
I
--------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
-
P
L
S
A
E
S
-
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
--
6
PsiBlast_PDB
85.02
45%
-146
- C9 -
4LZN
3
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
25
PsiBlast_CBE
84.80
45%
-144
- C9 -
2H08
5
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
M
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
31
PsiBlast_CBE
84.75
45%
-142
- C9 -
3EFH
4
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
62
HHSearch
84.72
45%
-146
- C9 -
3S5J
3
PRPS1_HUMAN
B:
[3-314]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
-
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
-
P
Q
E
-
D
K
M
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
S
9
PsiBlast_PDB
84.68
45%
-145
- C9 -
2HCR
8
PRPS1_HUMAN
A:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
3
PsiBlast_PDB
84.46
45%
-147
- C9 -
2H08
5
PRPS1_HUMAN
A:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
M
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
R
------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
27
PsiBlast_CBE
84.40
45%
-143
- C9 -
4LZO
3
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
T
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
11
PsiBlast_PDB
84.38
45%
-145
- C9 -
3S5J
3
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
32
PsiBlast_CBE
82.89
45%
-145
- C9 -
2HCR
8
PRPS1_HUMAN
B:
[3-313]
---------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
-
R
A
P
I
S
----
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
E
N
I
S
-
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
D
F
A
L
I
H
K
E
-------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
Q
E
D
-
K
M
-
K
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
-
48
PsiBlast_CBE
62.93
31%
-135
- C9 -
1U9Z
3
KPRS_METJA
C:
[9-275]
------------------
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
-
T
Q
K
N
Q
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
-
G
E
A
I
S
IRAL
A
K
I
Y
S
N
I
V
D
-----
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
D
K
L
N
----
D
P
I
V
L
A
P
D
K
G
A
L
E
F
A
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
--
Y
L
S
-
E
V
-
S
K
V
S
-----------------------------
19
PsiBlast_PDB
62.91
31%
-135
- C9 -
1U9Z
3
KPRS_METJA
A:
[9-275]
------------------
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
-
T
Q
K
N
Q
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
-
G
E
A
I
S
I
R
A
L
A
K
I
Y
S
N
I
V
D
-----
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
D
K
L
N
----
D
P
I
V
L
A
P
D
K
G
A
L
E
F
A
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
--
Y
L
S
-
E
V
-
S
K
V
S
-----------------------------
47
PsiBlast_CBE
62.86
31%
-135
- C9 -
1U9Z
3
KPRS_METJA
D:
[9-275]
------------------
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
-
T
Q
K
N
Q
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
-
G
E
A
I
S
IRAL
A
K
I
Y
S
N
I
V
D
-----
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
D
K
L
N
----
D
P
I
V
L
A
P
D
K
G
A
L
E
F
A
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
--
Y
L
S
-
E
V
-
S
K
V
S
-----------------------------
49
PsiBlast_CBE
62.56
31%
-135
- C9 -
1U9Z
3
KPRS_METJA
B:
[9-275]
------------------
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
-
T
Q
K
N
Q
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
-
G
E
A
I
S
IRAL
A
K
I
Y
S
N
I
V
D
-----
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
D
K
L
N
----
D
P
I
V
L
A
P
D
K
G
A
L
E
F
A
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
--
Y
L
S
-
E
V
-
S
K
V
S
-----------------------------