@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0468: (2016-03-15 )
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
Atome Classification :
(87 SA)
......---...10........20........30-------.------.-------......40........50....---.---.---------..------------60........70........80..-......90........100.......110.......120.......130.......140.......150.......160.......170.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHN
D
L
K
---
E
V
LL
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
DYQ-------G------
K
-------
P
L
V
C
V
G
ILKG
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---------H
L
------------
S
I
D
F
M
D
VSSYHGGTESTG
E
V
Q
I
I
K
-
D
L
G
SSIENK
D
V
L
I
I
E
D
I
L
ETGT
T
L
K
S
I
T
E
L
L
Q
SRKVN
S
L
E
I
V
T
LLDKPNRRKADI
E
A
K
YVGKKI
P
D
E
F
V
VGYGL
D
Y
R
E
L
Y
RNLPYIGTLKPEVYSN
2
PsiBlast_PDB
95.07
98%
-142
- C5 -
4RQB
6
?
A:
[9-186]
-
H
N
D
L
K
---
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
-------
G
------
K
-------
P
L
V
C
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---------
H
L
------------
S
I
D
F
M
D
V
S
S
Y
H
G
G
T
E
S
T
G
E
V
Q
I
I
K
-
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
K
A
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
S
N
1
PsiBlast_PDB
92.29
98%
-143
- C5 -
4RQA
7
?
A:
[9-184]
-
H
N
D
L
K
---
E
V
L
L
T
E
E
D
I
Q
N
I
C
K
E
L
G
A
Q
L
T
K
D
Y
Q
-------
G
------
K
-------
P
L
V
C
V
G
I
L
K
G
S
A
M
F
M
S
D
L
I
K
R
I
---
D
---
T
---------
H
L
------------
S
I
D
F
M
D
V
S
S
Y
-----
S
T
G
E
V
Q
I
I
K
-
D
L
G
S
S
I
E
N
K
D
V
L
I
I
E
D
I
L
E
T
G
T
T
L
K
S
I
T
E
L
L
Q
S
R
K
V
N
S
L
E
I
V
T
L
L
D
K
P
N
R
R
K
A
D
I
E
A
K
Y
V
G
K
K
I
P
D
E
F
V
V
G
Y
G
L
D
Y
R
E
L
Y
R
N
L
P
Y
I
G
T
L
K
P
E
V
Y
--
119
HHSearch
80.22
58%
-127
- C5 -
1YFZ
4
?
A:
[29-204]
-
M
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
7
PsiBlast_PDB
80.09
58%
-128
- C5 -
1YFZ
4
?
A:
[30-204]
--
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
6
PsiBlast_PDB
78.72
58%
-130
- C5 -
1R3U
1
?
A:
[30-204]
--
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
30
PsiBlast_CBE
78.43
58%
-127
- C5 -
1YFZ
4
?
B:
[30-204]
--
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
31
PsiBlast_CBE
77.00
58%
-124
- C5 -
1R3U
2
?
B:
[30-204]
--
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
120
HHSearch
76.41
57%
-130
- C5 -
2GEB
2
?
A:
[9-184]
-
M
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
8
PsiBlast_PDB
76.11
57%
-131
- C5 -
2GEB
2
?
A:
[10-184]
--
E
D
I
E
---
E
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
E
-------
G
------
K
-------
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
---
D
---
L
---------
P
L
------------
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
-
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
I
D
Y
A
E
K
Y
R
N
L
P
F
I
G
V
L
K
P
E
L
Y
--
27
PsiBlast_CBE
74.82
55%
-130
- C5 -
3H83
3
?
D:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
3
PsiBlast_PDB
74.73
55%
-133
- C5 -
3H83
5
?
A:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
23
PsiBlast_CBE
74.70
55%
-133
- C5 -
3KB8
7
?
B:
[26-204]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
N
29
PsiBlast_CBE
74.43
55%
-127
- C5 -
3H83
4
?
B:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
5
PsiBlast_PDB
74.21
55%
-137
- C5 -
3KB8
8
?
A:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
51
PsiBlast_CBE
74.17
47%
-137
- C5 -
4RHX
3
?
A:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
42
PsiBlast_CBE
74.16
44%
-134
- C5 -
4QYI
4
?
C:
[6-176]
--
I
E
I
K
---
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
------
E
-------
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---------
D
V
------------
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
V
------
72
PsiBlast_CBE
73.93
40%
-128
- C5 -
1P19
1
?
A:
[9-190]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
--
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
75
PsiBlast_CBE
73.76
40%
-129
- C5 -
1I0L
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
49
PsiBlast_CBE
73.68
47%
-138
- C5 -
4RHX
3
?
C:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E
L
S
A
T
T
-
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
-
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
21
PsiBlast_CBE
73.58
55%
-127
- C5 -
3KB8
4
?
D:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
34
PsiBlast_CBE
73.43
44%
-140
- C5 -
3O7M
2
?
C:
[6-176]
--
I
E
I
K
---
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
------
E
-------
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---------
D
V
------------
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
V
------
70
PsiBlast_CBE
73.38
40%
-138
- C5 -
1P19
1
?
C:
[9-190]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
----
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
46
PsiBlast_CBE
73.24
47%
-132
- C5 -
4RHY
3
?
B:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
4
PsiBlast_PDB
73.20
55%
-128
- C5 -
3HVU
2
?
A:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
45
PsiBlast_CBE
73.09
47%
-135
- C5 -
4RHY
3
?
C:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ETT----
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
------
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
56
PsiBlast_CBE
73.04
47%
-140
- C5 -
4RHU
3
?
B:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
--
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
111
HHSearch
73.00
56%
-126
- C5 -
3HVU
2
?
A:
[27-203]
-
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
25
PsiBlast_CBE
72.89
55%
-123
- C5 -
3HVU
2
?
C:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
63
PsiBlast_CBE
72.86
41%
-132
- C5 -
1I14
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
77
PsiBlast_CBE
72.84
40%
-128
- C5 -
1I13
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
11
PsiBlast_PDB
72.67
44%
-133
- C5 -
4QYI
4
?
B:
[6-176]
--
I
E
I
K
---
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
------
E
-------
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---------
D
V
------------
T
I
D
F
I
S
A
S
S
Y
G
N
Q
T
E
T
T
G
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
V
------
67
PsiBlast_CBE
72.65
40%
-128
- C5 -
1TC2
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
48
PsiBlast_CBE
72.55
47%
-131
- C5 -
4RHX
3
?
D:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
52
PsiBlast_CBE
72.52
47%
-134
- C5 -
4RHU
3
?
F:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
24
PsiBlast_CBE
72.50
55%
-126
- C5 -
3HVU
2
?
D:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
65
PsiBlast_CBE
72.31
40%
-127
- C5 -
1I0I
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
79
PsiBlast_CBE
72.26
40%
-127
- C5 -
1P18
4
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
44
PsiBlast_CBE
72.26
47%
-132
- C5 -
4RHY
3
?
D:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ATT----
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
82
PsiBlast_CBE
72.20
40%
-131
- C5 -
1P17
1
?
C:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
---
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
53
PsiBlast_CBE
71.86
47%
-132
- C5 -
4RHU
2
?
E:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
T------
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
------------
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
26
PsiBlast_CBE
71.86
55%
-127
- C5 -
3HVU
2
?
B:
[26-203]
M
N
Q
D
I
E
---
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
K
-------
N
------
T
-------
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
---
D
---
T
---------
Y
L
------------
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
-
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
S
V
Y
S
-
116
HHSearch
71.75
41%
-131
- C5 -
1TC1
2
?
A:
[4-187]
-
Y
E
F
A
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
GKGLRPY
V
------
N
-------
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
---
C
---
D
F
N
V
------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
----
84
PsiBlast_CBE
71.57
40%
-128
- C5 -
1P17
1
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
G
L
R
P
YVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
---
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
12
PsiBlast_PDB
71.51
44%
-139
- C5 -
3O7M
4
?
A:
[5-177]
-
N
I
E
I
K
---
D
T
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
E
-------
G
------
E
-------
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
---
K
---
N
---------
D
V
------------
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
-
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
V
T
-----
73
PsiBlast_CBE
71.25
40%
-126
- C5 -
1TC1
2
?
B:
[8-189]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
55
PsiBlast_CBE
71.11
47%
-130
- C5 -
4RHU
2
?
C:
[21-198]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
ELSATT-
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
50
PsiBlast_CBE
71.09
47%
-136
- C5 -
4RHX
3
?
B:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
SATT---
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
----------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
76
PsiBlast_CBE
70.97
40%
-126
- C5 -
1I0L
3
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
38
PsiBlast_CBE
70.66
47%
-136
- C5 -
1G9T
1
HPRT_ECOLI
B:
[5-175]
----
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
------
S
-------
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---------
S
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
15
PsiBlast_PDB
70.62
47%
-140
- C5 -
1G9T
1
HPRT_ECOLI
A:
[5-175]
----
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
------
S
-------
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---------
S
H
------------
E
V
D
F
M
T
A
S
---------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
47
PsiBlast_CBE
70.44
47%
-131
- C5 -
4RHY
3
?
A:
[21-200]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E------
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
Y
--
60
PsiBlast_CBE
70.02
47%
-134
- C5 -
4RHT
4
?
A:
[21-198]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
-------
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
81
PsiBlast_CBE
69.89
40%
-130
- C5 -
1P17
1
?
D:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
CDF
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
80
PsiBlast_CBE
69.80
40%
-125
- C5 -
1P18
4
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
19
PsiBlast_PDB
69.61
40%
-139
- C5 -
3ACC
3
?
A:
[12-179]
----------
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
------
K
-------
T
P
H
L
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
---
L
---------
P
L
------------
T
M
D
F
I
A
I
S
S
Y
-----------
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
Q
V
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
14
PsiBlast_PDB
69.42
47%
-136
- C5 -
1G9S
1
HPRT_ECOLI
A:
[5-175]
----
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
------
S
-------
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---------
S
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
69
PsiBlast_CBE
69.32
40%
-137
- C5 -
1P19
1
?
D:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
----------
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
78
PsiBlast_CBE
68.95
40%
-127
- C5 -
1I13
4
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
A
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
68
PsiBlast_CBE
68.93
40%
-127
- C5 -
1TC2
4
?
A:
[9-190]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
--
20
PsiBlast_PDB
68.85
40%
-138
- C5 -
3ACD
3
?
A:
[12-179]
----------
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
------
K
-------
T
P
H
L
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
---
L
---------
P
L
------------
T
M
D
F
I
A
I
S
------------
E
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
Q
V
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
115
HHSearch
68.62
34%
-130
- C5 -
1PZM
1
?
A:
[20-202]
-
Y
P
M
S
A
---
R
T
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
DFHLTA-
D
------
N
-------
P
L
Y
L
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
---
A
---
D
E
G
V
------
P
V
------------
K
V
E
F
I
C
A
S
-------------
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
E
----
71
PsiBlast_CBE
68.53
40%
-127
- C5 -
1P19
1
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
------------
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
64
PsiBlast_CBE
68.41
41%
-126
- C5 -
1I14
4
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
E
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
66
PsiBlast_CBE
68.38
40%
-121
- C5 -
1I0I
4
?
A:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
Q
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
39
PsiBlast_CBE
68.30
47%
-133
- C5 -
1G9S
1
HPRT_ECOLI
B:
[5-175]
----
M
K
HTV
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
K
DS-----
G
------
S
-------
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
---
Q
---
V
---------
S
H
------------
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
-
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
---------
74
PsiBlast_CBE
68.15
40%
-131
- C5 -
1TC1
2
?
A:
[8-187]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
---------
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
----
59
PsiBlast_CBE
68.04
47%
-132
- C5 -
4RHT
4
?
B:
[21-199]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
E-------------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
V
---
83
PsiBlast_CBE
67.91
40%
-124
- C5 -
1P17
1
?
B:
[9-191]
-----
E
---
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
K
-------
G
------
K
GLRPYVN
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
---
V
---------
P
V
------------
R
M
E
F
I
C
V
S
S
Y
------
S
G
Q
V
R
M
L
L
-
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
R
D
I
V
V
L
R
P
E
V
Y
A
-
117
HHSearch
67.90
39%
-125
- C5 -
3ACD
3
?
A:
[5-179]
F
T
P
G
N
G
---
P
V
Q
I
S
A
E
A
I
K
K
R
V
E
E
L
G
G
E
I
A
R
D
Y
Q
-------
G
------
K
-------
T
P
H
L
I
C
V
L
N
G
A
F
I
F
M
A
D
L
V
R
A
I
---
P
---
L
---------
P
L
------------
T
M
D
F
I
A
I
S
------------
E
L
L
K
-
D
L
R
L
P
I
H
G
R
D
V
I
V
V
E
D
I
V
D
T
G
L
T
L
S
Y
L
L
D
Y
L
E
A
R
K
P
A
S
V
R
V
A
A
L
L
S
K
P
S
R
R
Q
V
E
V
P
I
H
Y
L
G
F
E
I
E
D
A
Y
V
Y
G
Y
G
L
D
R
A
Q
F
D
R
N
L
P
F
I
T
S
I
R
P
E
----
88
PsiBlast_CBE
67.87
34%
-139
- C5 -
1PZM
1
?
A:
[27-202]
-----------
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
-------
D
FHLTAD
N
-------
P
L
Y
L
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
---
A
D
E
G
V
---------
P
V
------------
K
V
E
F
I
C
A
S
-------------
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
E
----
54
PsiBlast_CBE
67.23
47%
-127
- C5 -
4RHU
2
?
D:
[21-198]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
EATT---
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
---------
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
R
----
57
PsiBlast_CBE
66.82
47%
-134
- C5 -
4RHT
4
?
D:
[21-197]
---
D
I
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
---------------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
---
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
D
P
-----
58
PsiBlast_CBE
65.49
47%
-135
- C5 -
4RHT
4
?
C:
[23-195]
-----
K
---
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R
TT-----
G
------
Q
-------
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
---
P
---
V
---------
P
T
------------
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
-
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
-------
118
HHSearch
65.21
32%
-122
- C5 -
3OZF
4
?
A:
[55-243]
Y
K
K
Y
L
T
---
K
V
L
V
P
N
G
V
I
K
N
R
I
E
K
L
A
Y
D
I
K
K
V
Y
N
-------
N
------
E
-------
E
F
H
I
L
C
L
L
K
G
S
R
G
F
F
T
A
L
L
K
H
L
---
S
---
R
---------
I
H
N
Y
S
AVETSKPL
F
G
E
H
Y
V
R
V
K
S
Y
C
N
D
Q
-
S
T
G
T
L
E
I
V
S
-
E
D
L
S
C
L
K
G
K
H
V
L
I
V
E
D
I
I
D
T
G
K
T
L
V
K
F
C
E
Y
L
K
K
F
E
I
K
T
V
A
I
A
C
L
F
I
K
R
T
P
L
W
N
G
F
K
A
D
F
V
G
F
S
I
P
D
H
F
V
V
G
Y
S
L
D
Y
N
E
I
F
R
D
L
D
H
C
C
L
V
N
D
E
G
K
K
-
87
PsiBlast_CBE
64.23
34%
-144
- C5 -
1PZM
1
?
B:
[27-201]
-----------
L
V
T
Q
E
Q
V
W
A
A
T
A
K
C
A
K
K
I
A
A
D
Y
K
-------
D
FHLTAD
N
-------
P
L
Y
L
L
C
V
L
K
G
S
F
I
F
T
A
D
L
A
R
F
L
---
A
D
E
G
V
---------
P
V
------------
K
V
E
F
I
C
A
------------
V
R
M
L
L
-
D
V
R
D
S
V
E
N
R
H
I
M
L
V
E
D
I
V
D
S
A
I
T
L
Q
Y
L
M
R
F
M
L
A
K
K
P
A
S
L
K
T
V
V
L
L
D
K
P
S
G
R
K
V
D
V
L
V
D
Y
P
V
I
T
I
P
R
A
F
V
I
G
Y
G
M
D
F
A
E
S
Y
R
E
L
R
D
I
C
V
L
K
K
-----
93
PsiBlast_CBE
59.50
31%
-132
- C5 -
4RAO
3
HPRT_HUMAN
D:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
S
Y
--------
D
I
K
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
95
PsiBlast_CBE
59.35
31%
-136
- C5 -
4RAO
3
HPRT_HUMAN
B:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
NSDRSI
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
G
D
D
--
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
--
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
91
PsiBlast_CBE
59.23
31%
-141
- C5 -
4RAQ
3
HPRT_HUMAN
B:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SDR
S
I
P
M
------------
T
V
D
F
I
R
L
K
-----------
I
K
V
I
----
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
96
PsiBlast_CBE
59.13
31%
-137
- C5 -
4RAO
3
HPRT_HUMAN
A:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SR
S
I
-
P
M
------------
T
V
D
F
I
R
L
K
-------------------
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
92
PsiBlast_CBE
58.73
31%
-135
- C5 -
4RAQ
3
HPRT_HUMAN
A:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
S
-----------------
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
100
PsiBlast_CBE
58.60
31%
-131
- C5 -
4RAN
2
HPRT_HUMAN
A:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
G
D
--
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
94
PsiBlast_CBE
57.91
31%
-131
- C5 -
4RAO
3
HPRT_HUMAN
C:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
------------
K
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
98
PsiBlast_CBE
57.81
31%
-133
- C5 -
4RAN
2
HPRT_HUMAN
C:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
97
PsiBlast_CBE
57.40
31%
-142
- C5 -
4RAN
2
HPRT_HUMAN
D:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SDR
S
I
P
M
------------
T
V
D
F
I
R
L
--------------
V
I
G
G-----
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
89
PsiBlast_CBE
57.12
31%
-136
- C5 -
4RAQ
3
HPRT_HUMAN
D:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
K
-------------
V
I
G
--
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
90
PsiBlast_CBE
56.87
31%
-136
- C5 -
4RAQ
3
HPRT_HUMAN
C:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
S
D
R
S
I
P
M
------------
T
V
D
F
I
R
L
---------------
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
-
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------
99
PsiBlast_CBE
55.39
31%
-130
- C5 -
4RAN
2
HPRT_HUMAN
B:
[30-204]
---
D
L
E
---
R
V
F
I
P
H
G
L
I
M
D
R
T
E
R
L
A
R
D
V
M
K
E
M
G
-------
G
------
H
-------
H
I
V
A
L
C
V
L
K
G
G
Y
K
F
F
A
D
L
L
D
Y
I
---
K
---
A
L
N
R
N
SD
R
S
I
P
M
------------
T
V
D
F
I
R
----------------
I
G
G
D
D
L
S
T
L
T
G
K
N
V
L
I
V
E
D
I
I
D
T
G
K
T
M
Q
T
L
L
S
L
V
R
Q
Y
N
P
K
M
V
K
V
A
S
L
L
V
K
R
T
P
R
S
V
G
Y
K
P
D
F
V
G
F
E
I
P
D
K
F
V
V
G
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
----------