@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0472: (2016-03-15 )
MTKTKIMGILNVTPDSFSDGGKFNNVETAINRVKAMIDEGADIIDVGGVSTRPGHEMVTLEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDMINDQWAGLYDHRMFQIVAKYDAEIILMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGIPSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
Atome Classification :
(66 SA)
.........10........20.-...-....30.......-----.40----.........50........60........70...------..-.-----..80........90........100.......110.......120.....---------------...----130-----------------....--------.--------.--------.----------------------------.--------.140..--------------...--..150--.--------......160.......170---...-.-...180.......190---.----------------..-----.----------------.....200.......210-....----.--.------..-.220.......230.......240.---......250...-....260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTK
T
K
I
M
G
I
L
NVTPDSFSDGGK-FN
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D-----EG-----A
D
I
I
D
VGGVSTRPGH
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------VG-F-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
INDQWA
G
L
Y
D
H
R
M
F
Q
I
V
A
KY-D
A
E
I
I
---------------
L
M
H----N-------------------GNGN--------R--------D--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
KIAGIPSN
K
I
W
LDPGIGF---AKT-R-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----A----------------TE-----Y----------------
P
V
L
L
AT
S
R
K
R
F
T
K
E
M
M---GYDT----T--P------VE-RDEV
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
KENENARHNLS
2
PsiBlast_PDB
94.73
96%
-101
- C6 -
1AD1
2
DHPS_STAAU
A:
[1-264]
-
T
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
-
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
---------------
L
M
H
----
N
-------------------
G
N
G
N
--------
R
--------
D
--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
R
H
N
--
21
PsiBlast_CBE
93.69
100%
-103
- C6 -
4HB7
2
DHPS_STAAM
B:
[5-267]
-
T
K
T
K
I
M
G
I
L
N
V
T
-----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
I
V
A
K
Y
-
D
A
E
I
I
---------------
L
M
H
----
N
-------------------
G
N
G
N
--------
R
--------
D
--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
R
H
---
1
PsiBlast_PDB
93.45
100%
-99
- C6 -
4HB7
6
DHPS_STAAM
A:
[5-267]
-
T
K
T
K
I
M
G
I
L
N
V
T
-----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
I
V
A
K
Y
-
D
A
E
I
I
---------------
L
M
H
----
N
-------------------
G
N
G
N
--------
R
--------
D
--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
R
H
---
99
Fugue
92.68
93%
-99
- C6 -
1AD1
2
DHPS_STAAU
A:
[1-264]
-
T
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
-
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
---------------
L
M
H
----
N
--------------------
G
N
G
--------
N
--------
R
D-------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
-
R
H
N
-
22
PsiBlast_CBE
90.71
96%
-109
- C6 -
1AD4
3
DHPS_STAAU
B:
[1-266]
-
T
K
T
K
I
M
G
I
L
N
V
T
------------
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
-------
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
---------------
L
M
H
----
N
-------------------
G
N
G
N
--------
R
--------
D
--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
R
H
N
F
S
23
PsiBlast_CBE
90.31
96%
-100
- C6 -
1AD1
1
DHPS_STAAU
B:
[1-266]
-
T
K
T
K
I
M
G
I
L
N
V
T
P
-----------
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
-----
A
D
I
I
D
V
G
G
V
S
T
-----
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
------
V
G
-
F
-----
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
---------------
L
M
H
----
N
-------------------
G
N
G
N
--------
R
--------
D
--------
E
----------------------------
P
--------
V
V
E
E
M
L
--------------
T
S
L
--
L
A
Q
A
H
--
Q
--------
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
---
A
K
T
-
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
-----
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
----
T
--
P
------
V
E
-
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---
E
L
N
A
K
L
A
K
G
I
D
F
-
L
K
E
N
E
N
A
R
H
N
F
S
9
PsiBlast_PDB
74.59
45%
-99
- C6 -
3H22
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
7
PsiBlast_PDB
74.42
45%
-96
- C6 -
1TX2
6
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
43
PsiBlast_CBE
74.41
45%
-99
- C6 -
3TYC
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
15
PsiBlast_PDB
74.40
45%
-95
- C6 -
3H2F
4
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
26
PsiBlast_CBE
74.14
45%
-91
- C6 -
4NIR
8
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
36
PsiBlast_CBE
74.07
45%
-100
- C6 -
4D8Z
6
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
42
PsiBlast_CBE
74.06
45%
-97
- C6 -
3TYD
8
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
39
PsiBlast_CBE
74.06
45%
-99
- C6 -
3TYE
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
52
PsiBlast_CBE
74.03
45%
-100
- C6 -
1TX2
6
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
44
PsiBlast_CBE
74.02
45%
-98
- C6 -
3TYB
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
55
PsiBlast_CBE
74.01
45%
-93
- C6 -
1TWS
6
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
10
PsiBlast_PDB
73.97
45%
-89
- C6 -
3H23
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
71
PsiBlast_CBE
73.90
37%
-102
- C6 -
2VEG
2
DHPS_STRR6
A:
[9-303]
--
K
T
V
I
C
G
I
I
N
V
T
P
----------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
-----
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
------
R
K
E
S
-----
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
---------------
I
M
F
----
N
P
V
M
A
R
P
QHPSSLIFPHFGF--
A
F
--------
T
------------------EL
A
D
F
E
T
L--------------------
P
--------
I
E
E
L
M
E
--------------
A
F
F
--
E
R
A
L
A
--
R
--------
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
---
G
L
T
-
K
-
K
E
N
L
L
L
L
R
D
L
D
K
L
H
-----
Q
----------------
K
G
-----
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
E
V
----
N
--
P
ET
E
L
G
F
R
N
-
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
-
A
D
----------
41
PsiBlast_CBE
73.88
45%
-101
- C6 -
3TYD
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
50
PsiBlast_CBE
73.87
45%
-100
- C6 -
3H2A
5
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
54
PsiBlast_CBE
73.73
45%
-100
- C6 -
1TWZ
5
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
49
PsiBlast_CBE
73.61
45%
-102
- C6 -
3H2C
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
-------
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
75
PsiBlast_CBE
73.58
36%
-109
- C6 -
2Y5S
13
?
A:
[22-274]
--
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
------
R
P
-
L
-----
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
-
G
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
---------------
A
M
H
M
L
G
E
P
-------------------
Q
T
M
Q
--------
V
--------
G
--------
E
----------------------------
P
DYGD----
V
V
T
D
V
R
--------------
D
F
L
--
A
A
R
A
Q
--
A
--------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
-----
P
----------------
A
R
PDGRA
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---
G
-
G
K
----
P
--
P
------
L
E
-
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
----------------------------
45
PsiBlast_CBE
73.46
45%
-98
- C6 -
3TYA
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
46
PsiBlast_CBE
73.41
45%
-99
- C6 -
3H2N
5
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
20
PsiBlast_PDB
73.37
45%
-97
- C6 -
3TYB
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
40
PsiBlast_CBE
73.20
45%
-91
- C6 -
3TYE
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
53
PsiBlast_CBE
73.07
45%
-100
- C6 -
1TX0
6
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
58
PsiBlast_CBE
73.01
42%
-112
- C6 -
2DZB
1
?
B:
[26-272]
L
D
R
V
R
L
L
G
V
L
N
L
T
P
D
------------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
-----
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
------
L
S
-
L
-----
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
L
R
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
---------------
V
M
H
----
M
-------------------
P
---AHA-----
R
--------
Y
--------
R
----------------------------
D
--------
V
V
A
E
V
K
--------------
A
F
L
--
E
A
Q
A
R
--
R
--------
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
-----
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
V
E
-----
D
--
P
------
A
Q
-
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
----------------------------
12
PsiBlast_PDB
72.90
45%
-94
- C6 -
3H26
4
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
35
PsiBlast_CBE
72.87
45%
-95
- C6 -
4D9P
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
16
PsiBlast_PDB
72.83
45%
-92
- C6 -
3H2M
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
37
PsiBlast_CBE
72.82
45%
-98
- C6 -
4D8Z
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
13
PsiBlast_PDB
72.81
45%
-99
- C6 -
3H2A
4
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
51
PsiBlast_CBE
72.80
45%
-99
- C6 -
3H24
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
47
PsiBlast_CBE
72.79
45%
-100
- C6 -
3H2M
7
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
19
PsiBlast_PDB
72.70
45%
-94
- C6 -
3TYA
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
6
PsiBlast_PDB
72.65
45%
-95
- C6 -
1TX0
6
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
11
PsiBlast_PDB
72.50
45%
-91
- C6 -
3H24
6
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
34
PsiBlast_CBE
72.32
45%
-98
- C6 -
4D9P
5
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
33
PsiBlast_CBE
72.24
45%
-95
- C6 -
4DAI
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
31
PsiBlast_CBE
72.23
45%
-96
- C6 -
4DB7
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
80
HHSearch
72.13
35%
-96
- C6 -
2Y5S
13
?
A:
[21-293]
-
E
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
------
R
P
-
L
-----
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
Q
-
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
---------------
A
M
H
----
M
-------------------
L
G
E
P
--------
Q
--------
T
M
Q
V
G
E
PDY
G
----------------------------
D
--------
V
V
T
D
V
R
--------------
D
F
L
--
A
A
R
A
Q
--
A
--------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
-
V
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
-----
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---
G
G
K
-----
P
--
P
------
L
E
-
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
---
A
A
T
V
D
A
L
S
V
W
N
A
-
V
R
A
A
A
R
Q
-----
38
PsiBlast_CBE
72.07
45%
-97
- C6 -
4D8A
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
8
PsiBlast_PDB
71.98
45%
-93
- C6 -
3H21
4
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
17
PsiBlast_PDB
71.96
45%
-95
- C6 -
3H2N
5
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
32
PsiBlast_CBE
71.92
45%
-101
- C6 -
4DAI
6
?
B:
[39-291]
--
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
74
PsiBlast_CBE
71.65
36%
-107
- C6 -
2Y5S
9
?
B:
[22-274]
--
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
------
R
P
-
L
-----
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
-
G
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
---------------
A
M
H
M
L
G
E
P
-------------------
Q
T
M
Q
--------
V
--------
G
--------
E
----------------------------
P
DYGD----
V
V
T
D
V
R
--------------
D
F
L
--
A
A
R
A
Q
--
A
--------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
-----
P
----------------
A
R
PDGRA
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---
G
-
G
K
----
P
--
P
------
L
E
-
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
----------------------------
59
PsiBlast_CBE
71.50
42%
-107
- C6 -
2DZB
1
?
A:
[26-272]
L
D
R
V
R
L
L
G
V
L
N
L
T
P
---------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
-----
A
D
I
L
D
L
G
A
E
S
----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
------
L
S
-
L
-----
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
L
R
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
---------------
V
M
H
----
M
-------------------
P
V
P
D
PATMMAHA
R
--------
Y
--------
R
----------------------------
D
--------
V
V
A
E
V
K
--------------
A
F
L
--
E
A
Q
A
R
--
R
--------
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
-----
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
V
E
-----
D
--
P
------
A
Q
-
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
----------------------------
18
PsiBlast_PDB
71.30
45%
-92
- C6 -
3H2O
3
?
A:
[39-291]
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
------
S
K
E
V
-----
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
---------------
L
M
H
----
N
-------------------
R
D
N
M
--------
N
--------
Y
--------
R
----------------------------
N
--------
L
M
A
D
M
I
--------------
A
D
L
--
Y
D
S
I
K
--
I
--------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
-----
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----
D
L
----
P
--
V
------
E
E
-
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
---
K
E
M
S
R
M
A
K
M
M
D
A
-
M
-----------
60
PsiBlast_CBE
70.93
42%
-107
- C6 -
2DZA
1
?
B:
[26-272]
L
D
R
V
R
L
L
G
V
L
N
L
T
P
D
S
--------------
A
L
E
R
A
R
E
M
V
A
-----
E
G
-----
A
D
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
------
L
S
-
L
-----
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
-
T
G
L
R
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
---------------
V
M
H
----
M
-------------------
P
V
P
D
PATMMAHA
R
--------
Y
--------
R
----------------------------
D
--------
V
V
A
E
V
K
--------------
A
F
L
--
E
A
Q
A
R
--
R
--------
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
-----
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
V
E
-----
D
--
P
------
A
Q
-
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
----------------------------
69
PsiBlast_CBE
70.88
37%
-99
- C6 -
1AJ2
2
DHPS_ECOLI
A:
[12-281]
L
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
------
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
-
I
R
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
---------------
L
M
H
M
Q
G
-
N
-------------------
P
K
T
M
--------
Q
--------
E
--------
A
----------------------------
P
K
Y
DD----
V
F
A
E
V
N
--------------
R
Y
F
--
I
E
Q
I
A
--
R
--------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
-----
N
V
----
G
--
P
------
S
E
-
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
---
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
Y
---
70
PsiBlast_CBE
70.71
37%
-95
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[12-281]
L
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
------
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
-
I
R
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
---------------
L
M
H
M
Q
G
-
N
-------------------
P
K
T
M
--------
Q
--------
E
--------
A
----------------------------
P
K
Y
DD----
V
F
A
E
V
N
--------------
R
Y
F
--
I
E
Q
I
A
--
R
--------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
-----
N
V
----
G
--
P
------
S
E
-
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
---
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
Y
---
67
PsiBlast_CBE
70.50
37%
-103
- C6 -
3TYU
1
?
A:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
-------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
M
QG------------------------
M
--------
Q
--------
H
--------
S
----------------------------
P
--------
Y
Y
D
D
L
M
--------------
T
D
I
N
R
F
F
Q
H
H
I
E
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
65
PsiBlast_CBE
70.35
37%
-94
- C6 -
3TYZ
4
?
A:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
M
Q
G
-
Q
-------------------
P
K
N
M
--------
Q
--------
H
--------
S
----------------------------
P
--------
Y
Y
D
D
L
M
--------------
T
D
I
N
R
F
F
Q
H
H
I
E
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
85
HHSearch
70.25
31%
-91
- C6 -
3TR9
4
?
A:
[26-293]
-
S
E
P
A
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
---
L
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
-----
A
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
------
K
K
R
F
-----
P
Q
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
I
N
D
Q
R
A
L
Q
L
-
D
D
A
L
T
T
V
S
A
L
-
K
T
P
V
C
---------------
L
M
H
----
F
-------------------
P
S
E
T
--------
R
--------
K
PGSTT
H
--
F
----------------------------
Y
--------
F
L
Q
S
V
K
--------------
K
E
L
--
Q
E
S
I
Q
--
R
--------
C
K
K
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GNY
G
K
N
-
V
-
S
E
N
F
Y
L
L
N
K
L
P
E
F
V
-----
A
----------------
M
G
-----
L
----------------
P
V
L
S
G
W
S
R
K
S
M
I
G
D
V
L
---
N
Q
P
--------
P
------
E
N
-
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
H
G
A
S
I
I
R
T
H
D
V
---
K
A
T
R
E
A
I
K
I
A
T
Y
-
T
R
S
V
D
-------
62
PsiBlast_CBE
70.22
37%
-96
- C6 -
3TZF
3
?
B:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
M
Q
G
-
Q
-------------------
P
K
N
M
--------
Q
--------
H
--------
S
----------------------------
P
--------
Y
Y
D
D
L
M
--------------
T
D
I
N
R
F
F
Q
H
H
I
E
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
64
PsiBlast_CBE
69.58
37%
-96
- C6 -
3TYZ
4
?
B:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
MQG-
Q
-------------------
P
K
N
M
--------
Q
--------
H
--------
S
----------------------------
P
--------
Y
Y
D
D
L
M
--------------
T
D
I
NR
F
F
Q
H
H
IE
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
63
PsiBlast_CBE
69.33
37%
-95
- C6 -
3TZF
2
?
A:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
M
Q
G
-
Q
-------------------
P
K
N
M
--------
Q
--------
H
--------
S
----------------------------
P
--------
Y
Y
D
D
L
M
--------------
T
D
I
N
R
F
F
Q
H
H
I
E
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
61
PsiBlast_CBE
69.05
40%
-101
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[5-258]
--
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
-
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
-----
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
------
A
A
-
Q
-----
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
---------------
L
M
H
----
W
-------------------
R
A
V
S
--------
A
--------
D
--------
T
----------------------------
P
HVPVRYGN
V
V
A
E
V
R
--------------
A
D
L
--
L
A
S
V
A
--
D
--------
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
-----
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A--
G
P
D
G
----
V
MR
P
------
T
D
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
---
R
------------------------
79
HHSearch
68.98
38%
-92
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
--
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
-
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
-----
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
------
A
A
-
Q
-----
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
---------------
L
M
H
----
W
-------------------
R
A
V
S
--------
A
DTPHVPVR
Y
--------
G
----------------------------
N
--------
V
V
A
E
V
R
--------------
A
D
L
--
L
A
S
V
A
--
D
--------
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
-----
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---
A
G
P
D
GVMR
P
--
T
------
D
G
-
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
---
R
A
S
V
D
A
I
K
V
V
E
A
-
W
M
G
A
E
-------
81
HHSearch
68.88
36%
-87
- C6 -
2BMB
1
FOL1_YEAST
A:
[223-543]
-
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
-
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
-----
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
------
R
E
S
T
ELPQD
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
---------------
L
S
H
----
T
-------------------
R
G
D
I
--------
S
--------
T
MNRLAHY-
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
--------
L
I
R
N
V
G
--------------
Q
E
I
--
G
E
R
Y
I
--
K
--------
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
-----
M
----------------
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
---
K
D
V
-----
D
--
A
------
K
Q
-
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
---
K
N
C
S
K
S
I
K
L
A
D
A
-
I
Y
K
G
--------
83
HHSearch
68.75
37%
-88
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[13-279]
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
------
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
---------------
L
M
H
----
M
-------------------
Q
G
N
P
--------
K
TM
Q
E
A
P
K
-
Y
--------
D
----------------------------
D
--------
V
F
A
E
V
N
--------------
R
Y
F
--
I
E
Q
I
A
--
R
--------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
V
G
--------
P
------
S
E
-
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
---
K
E
T
V
E
A
M
R
V
V
E
A
-
T
L
S
A
K
E
N
K
----
66
PsiBlast_CBE
64.40
37%
-119
- C6 -
3TYU
1
?
B:
[15-263]
L
S
R
P
Q
V
M
G
I
L
N
-------------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
-----
A
T
L
I
D
I
G
---------------
E
L
D
R
V
V
P
V
V
E
A
L
------
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
---------------
L
M
H
M
Q---------------------------------------------------------------------------------------------
D
L
M
--------------
T
D
I
N
R
F
F
Q
H
H
I
E
R
--------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
-----
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
----
P
--
P
------
Q
Q
-
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
---
K
------------------------
76
PsiBlast_CBE
60.40
31%
-76
- C6 -
2BMB
1
FOL1_YEAST
A:
[222-538]
V
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
-
I
E
S
Q
L
N
D
I
I
K
L
C
K
-----
D
A
L
YLHE
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
STEL
P
Q
-
D
-----
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
--
N
P
E
I
C
Y
I
L
S
H
T
R
GDISTMNR
L
A
H
----
Y
-------------------
E
N
F
A
--------
L
--------
G
--------
D
----------------------------
S
--------
I
Q
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
--
I
R
N
V
G
--
Q
E
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
----------------
Y
S
-----
F
T
M
N
S
NN
S
Q
V
Y
V
N
LRNM
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
---
K
-
D
V
----
D
--
A
------
K
Q
-
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
---
K
N
C
S
K
S
I
K
L
A
D
--------------