@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0475: (2016-03-15 )
MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEVKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
Atome Classification :
(29 SA)
.........10....-....20........30........40........50........60........70...-..-...80........90.....----...100-.-....----...110.........120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290......-.300......-------.310.......320...-..-..-330.....---.-..340...---....350...----..---------..360.......370......------------------------------------------.380.......390........400.......410.......420.......430.......440.......450.......460.......470.......480.......490...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSE
E
M
N
D
Q
M
L
V
R
R
Q
K
-
L
Q
E
L
Y
DLGIDPFGSKFDRSG
L
S
S
D
L
K
E
E
W
D
Q
Y
S
K
E
E
L
V
E
K
EADS
H
V
A
I
A
G
R
L
M
TKRGKG-KA-
G
F
A
H
V
Q
D
LA
G
Q
I
Q
I
Y
V
R
KDQ----VGDDE--F-DLWK----NADL--G
D
I
VGVE
G
V
M
F
KTNTG
E
L
S
V
K
A
K
K
F
T
L
L
T
K
SLRPL
P
D
K
F
H
G
L
Q
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
ITNED
S
T
R
T
F
I
N
R
S
K
I
I
Q
E
M
R
N
Y
LNNKG
F
L
E
VET
P
M
M
H
Q
IAGGAAAR
P
F
V
THHNALD
A
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
NEGVSTRHNPE
F
T
M
I
E
L
Y
E
A
Y
A
D
Y
H
D
I
M
D
L
T
E
S
M
V
R
H
I
A
N
E
V
L-GS
A
K
V
Q
YNG
E
-------
T
I
D
L
E
SA
W
T
R
L
H
I
V
D
A
V
-
K
E
-AT-G-V
D
F
Y
EV---K-S
D
E
E
A
K
A
L
---
A
K
EHGI
E
I
K
D
----
T
M
---------
K
Y
G
H
I
L
N
E
F
F
E
Q
K
V
E
E
T
LIQ
P
------------------------------------------
T
F
IYGHPTEISP-LAKKNPEDPRFT
D
R
F
E
L
F
I
V
GREHA
N
A
F
TELNDPIDQKG
R
F
E
A
Q
L
V
E
KAQGN
D
E
A
H
E
M
D
E
D
Y
I
E
A
L
EYGMPPTGGL
G
I
G
I
D
R
L
V
M
L
LTDSPSI
R
D
V
L
LFPYMRQK
2
PsiBlast_PDB
98.75
72%
-79
- C5 -
3E9I
4
SYK_GEOSE
A:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
22
PsiBlast_CBE
98.34
72%
-80
- C5 -
3E9I
4
SYK_GEOSE
C:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
26
PsiBlast_CBE
98.33
72%
-78
- C5 -
3E9H
2
SYK_GEOSE
B:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
27
PsiBlast_CBE
98.29
72%
-80
- C5 -
3A74
5
SYK_GEOSE
D:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
29
PsiBlast_CBE
98.18
72%
-80
- C5 -
3A74
5
SYK_GEOSE
B:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
24
PsiBlast_CBE
97.80
72%
-79
- C5 -
3E9H
2
SYK_GEOSE
D:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
3
PsiBlast_PDB
97.55
72%
-79
- C5 -
3A74
5
SYK_GEOSE
A:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
1
PsiBlast_PDB
97.37
72%
-80
- C5 -
3E9H
2
SYK_GEOSE
A:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
78
HHSearch
97.35
73%
-79
- C5 -
3A74
5
SYK_GEOSE
A:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
--
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
21
PsiBlast_CBE
97.29
72%
-78
- C5 -
3E9I
4
SYK_GEOSE
D:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
28
PsiBlast_CBE
97.17
72%
-79
- C5 -
3A74
5
SYK_GEOSE
C:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
23
PsiBlast_CBE
96.79
72%
-77
- C5 -
3E9I
4
SYK_GEOSE
B:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
25
PsiBlast_CBE
96.71
72%
-80
- C5 -
3E9H
2
SYK_GEOSE
C:
[4-492]
---
E
L
N
D
Q
L
R
V
R
R
E
K
-
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
--
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
-
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
----
V
G
E
Q
Q
--
Y
-
E
L
F
K
----
I
S
D
L
--
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
-
G
T
T
K
I
Q
Y
G
E
H
-------
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
-
K
E
-
Y
V
-
G
-
V
D
F
W
R
Q
---
M
-
S
D
E
E
A
R
E
L
---
A
K
E
H
G
V
E
V
A
P
----
H
M
---------
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
------------------------------------------
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
4
PsiBlast_PDB
92.21
53%
-71
- C5 -
1LYL
1
SYK2_ECOLI
A:
[14-501]
----
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
6
PsiBlast_PDB
91.48
53%
-72
- C5 -
1E1T
11
SYK2_ECOLI
A:
[13-501]
---
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
5
PsiBlast_PDB
91.41
53%
-74
- C5 -
1E1O
9
SYK2_ECOLI
A:
[13-501]
---
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
68
Fugue
91.19
52%
-69
- C5 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
----
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
--
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
-------
D
S
L
P
--
E
-
G
V
Y
N
DQFK
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
P
E
-
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-
8
PsiBlast_PDB
90.99
53%
-74
- C5 -
1E24
7
SYK2_ECOLI
A:
[13-501]
---
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
30
PsiBlast_CBE
90.64
53%
-74
- C5 -
1LYL
1
SYK2_ECOLI
C:
[14-501]
----
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
7
PsiBlast_PDB
90.58
53%
-73
- C5 -
1E22
11
SYK2_ECOLI
A:
[13-501]
---
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
--
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
LPEG
V
Y
N
D
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
E
T
D
M
A
D
L
---
D
-
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
79
HHSearch
90.47
53%
-72
- C5 -
1E1O
9
SYK2_ECOLI
A:
[12-502]
--
I
D
F
N
D
E
L
R
N
R
R
E
K
-
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
--
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
----
L
P
E
G
V
--
Y
N
D
Q
F
K
----
K
W
D
L
--
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
-
G
T
T
K
V
T
Y
G
E
H
-------
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
-
Y
R
-
P
-
E
T
D
M
A
D
---
L
D
N
F
D
A
A
K
A
L
---
A
E
S
I
G
I
T
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-
9
PsiBlast_PDB
90.01
52%
-70
- C5 -
1BBU
1
SYK1_ECOLI
A:
[13-501]
---
D
L
N
N
E
L
K
T
R
R
E
K
-
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
--
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
-
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
LPEG
V
Y
N
E
Q
--
F
-
K
K
W
-------
D
L
--
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
-
G
K
T
E
V
T
Y
G
D
V
-------
T
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
-
K
K
Y
R
P
-
E
-
T
D
M
A
D
L
---
D
-
N
F
D
S
A
K
A
I
---
A
E
S
I
G
I
H
V
E
K
----
S
W
---------
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
------------------------------------------
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
--
11
PsiBlast_PDB
89.19
52%
-75
- C5 -
4EX5
1
SYK_BURTA
A:
[43-527]
-----------
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
--
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
----
V
G
A
E
T
--
Y
-
D
A
F
K
----
K
W
D
L
--
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
-
G
T
A
T
I
Q
Y
Q
G
R
-------
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
-
A
P
-
S
-
Y
T
D
G
Q
L
---
S
-
D
D
A
F
L
R
S
E
---
L
K
R
L
G
V
D
V
T
Q
PAFL
N
A
---------
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
------------------------------------------
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-
32
PsiBlast_CBE
88.96
52%
-75
- C5 -
4EX5
1
SYK_BURTA
B:
[43-527]
-----------
R
R
D
K
-
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
--
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
-
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
----
V
G
A
E
T
--
Y
-
D
A
F
K
----
K
W
D
L
--
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
-
G
T
A
T
I
Q
Y
Q
G
R
-------
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
-
A
P
-
S
-
Y
T
D
G
Q
L
---
S
-
D
D
A
F
L
R
S
E
---
L
K
R
L
G
V
D
V
T
Q
PAFL
N
A
---------
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
------------------------------------------
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-
36
PsiBlast_CBE
84.89
42%
-68
- C5 -
4YCU
4
SYK_HUMAN
B:
[4-506]
---
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
---
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
----
Y
K
S
E
E
--
E
-
F
I
H
I
----
N
N
K
L
RR
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
-
G
S
Y
K
V
T
Y
H
P
D
GPE
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
-
E
K
-
A
L
-
G
-
M
K
L
P
E
T
NLF
E
-
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
----
P
R
---------
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
------------------------------------------
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
--
14
PsiBlast_PDB
84.60
42%
-68
- C5 -
4YCU
4
SYK_HUMAN
A:
[4-506]
---
D
P
N
Q
Y
Y
K
I
R
S
Q
A
-
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
---
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
-
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
----
Y
K
S
E
E
--
E
-
F
I
H
I
----
N
N
K
L
RR
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
-
G
S
Y
K
V
T
Y
H
P
D
GPE
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
-
E
K
-
A
L
-
G
-
M
K
L
P
E
T
NLF
E
-
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
----
P
R
---------
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
------------------------------------------
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
--
20
PsiBlast_PDB
78.34
37%
-67
- C5 -
4UPA
1
?
A:
[9-568]
----
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
----
S
D
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
----
Y
E
N
K
E
D
F
V
-
S
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
L
E
I
K
----------------------------------------------------------------
K
K
M
----
V
L
D
FTAP
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
FNA
I
C
A
E
PQT
T
A
R
V
M
D
K
L
F
G
DLIEVDLV
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--
52
PsiBlast_CBE
77.71
37%
-62
- C5 -
4UP7
1
?
A:
[9-568]
----
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
----
S
D
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
----
Y
E
N
K
E
D
F
V
-
S
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
L
E
I
K
------------------------------------------------------------
F
V
T
E
K
K
M
----
V
L
D
FTAP
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
PQT
T
A
R
V
M
D
K
L
F
G
DLIEVDLVQP
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--
19
PsiBlast_PDB
77.71
37%
-65
- C5 -
4UP9
1
?
A:
[9-568]
----
L
S
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
----
S
D
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
----
Y
E
N
K
E
D
F
V
-
S
L
T
K
----
M
I
Y
R
--
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
S
T
K
L
E
I
K
-----------------------------------------------------------------
K
M
----
V
L
D
FTAP
F
K
R
I
S
Y
V
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
FN
A
I
C
A
E
PQT
T
A
R
V
M
D
K
L
F
G
DLIEVDLVQP
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
--